Pub Date : 2024-02-12DOI: 10.9734/or/2024/v19i1411
Houda Bezza, Amine Mounsif, Zineb Algouti, Y. Bennouk, Houssaine Ait Lhaj, Mohamed Kriet, Fouad Elasri
Butterfly shaped pattern dystophy (BPD) is a inherited macular disease which is characterized by the accumulation of pigment/lipofuscin in the retinal pigment epithelium, it might be misdiagnosed as age-related macular degeneration (AMD). Retinal imaging is a useful tool for the differential diagnosis of pattern dystrophy. In this report, we describe a 64 year old man presented metamorphopsia and reduced visual acuity in both eyes. Fundus examination showed an area of depigmentation delimited resembling a butterfly. The OCT revealed a subfoveal hyperreflective deposit above the retinal pigment epithelium (RPE) while fundus autofluorescence (FAF) shows hypoautofluorescent areas outlined by a lipofuscin deposits as hyperautofluorescent Finally, fluoroscein angiography (FFA) revealed early macular hyperfluorescence.
{"title":"Butterfly-shaped Pattern Dystrophy : Findings of Retinal Imaging","authors":"Houda Bezza, Amine Mounsif, Zineb Algouti, Y. Bennouk, Houssaine Ait Lhaj, Mohamed Kriet, Fouad Elasri","doi":"10.9734/or/2024/v19i1411","DOIUrl":"https://doi.org/10.9734/or/2024/v19i1411","url":null,"abstract":"Butterfly shaped pattern dystophy (BPD) is a inherited macular disease which is characterized by the accumulation of pigment/lipofuscin in the retinal pigment epithelium, it might be misdiagnosed as age-related macular degeneration (AMD). Retinal imaging is a useful tool for the differential diagnosis of pattern dystrophy. In this report, we describe a 64 year old man presented metamorphopsia and reduced visual acuity in both eyes. Fundus examination showed an area of depigmentation delimited resembling a butterfly. The OCT revealed a subfoveal hyperreflective deposit above the retinal pigment epithelium (RPE) while fundus autofluorescence (FAF) shows hypoautofluorescent areas outlined by a lipofuscin deposits as hyperautofluorescent Finally, fluoroscein angiography (FFA) revealed early macular hyperfluorescence. ","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"57 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139843463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-30DOI: 10.9734/or/2024/v19i1410
Juliet Mulenga, Brian Ng’andwe, Phyliss Moonga, John Buchan, Allen Foster
Purpose: Orbital, Oculoplastic including Ocular Oncology are not only sight threatening but potentially life threatening. This study examines the causes of these conditions at University Teaching Hospitals-Eye Hospital in Lusaka Zambia. Methods: A retrospective review of 150 case files of patients with an Orbital, Oculoplastic and Ocular Oncology diagnosis presenting at UTHs-EH over a 4-year period, 2018-2021. Results: Of the 150 cases 54% were under the age of 40 years. The most common condition seen was squamous cell carcinoma of the conjunctiva (SCC), usually confined to the globe, but sometimes spreading to the orbit. There was a positive association between HIV infection and SCC. Conclusion: This study at University Teaching Hospital revealed a spectrum of orbital and oculoplastic diseases, with Squamous Cell Carcinoma emerging as a predominant concern. The insights gained pave the way for enhanced service delivery. These findings, while specific to Zambia, hold relevance for the broader African context, offering a basis for future assessments, interventions, and policy enhancements.
{"title":"Etiological Factors Contributing to Orbital and Oculoplastic Conditions at University Teaching Hospital in Zambia: A Comprehensive Analysis","authors":"Juliet Mulenga, Brian Ng’andwe, Phyliss Moonga, John Buchan, Allen Foster","doi":"10.9734/or/2024/v19i1410","DOIUrl":"https://doi.org/10.9734/or/2024/v19i1410","url":null,"abstract":"Purpose: Orbital, Oculoplastic including Ocular Oncology are not only sight threatening but potentially life threatening. This study examines the causes of these conditions at University Teaching Hospitals-Eye Hospital in Lusaka Zambia. \u0000Methods: A retrospective review of 150 case files of patients with an Orbital, Oculoplastic and Ocular Oncology diagnosis presenting at UTHs-EH over a 4-year period, 2018-2021. \u0000Results: Of the 150 cases 54% were under the age of 40 years. The most common condition seen was squamous cell carcinoma of the conjunctiva (SCC), usually confined to the globe, but sometimes spreading to the orbit. There was a positive association between HIV infection and SCC. \u0000Conclusion: This study at University Teaching Hospital revealed a spectrum of orbital and oculoplastic diseases, with Squamous Cell Carcinoma emerging as a predominant concern. The insights gained pave the way for enhanced service delivery. These findings, while specific to Zambia, hold relevance for the broader African context, offering a basis for future assessments, interventions, and policy enhancements.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"205 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140484057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-03DOI: 10.9734/or/2024/v19i1408
S. Suman, Arushi Kumar, H. U. Rathod
Lens coloboma is a rare congenital anomaly that occurs due to failure of the foetal fissure to close completely causing an incomplete formation of the lens, so usually inferonasal. Temporal lens coloboma is extremely rare; reported cases were associated with ocular or systemic anomalies. We report a rare case of unilateral atypical temporal lens coloboma without any iris abnormality and posterior segment coloboma or any other ocular or systemic anomaly. An 18-year-old female presented with a gradually progressive painless diminution of vision in her left eye for two years. There was no history of trauma, and family history was non-contributory. The systemic examination was normal. Ocular examination revealed a vision of 6/6 in the right eye and 6/60 in the left eye improving to 6/24 with pinhole and unilateral atypical temporal coloboma of the crystalline lens in the left eye after dilatation. The rest of the anterior segment and fundus examination was normal. No abnormality was detected in the right eye. The best corrected visual acuity of 6/6 OD and 6/9 OS was achieved with spectacle correction at 6 months of follow-up. This case is a rare presentation of unilateral atypical coloboma located temporally without any iris abnormality and posterior segment coloboma or any other ocular or systemic anomaly. Early correction of refractive error and astigmatism results in good prognosis.
{"title":"Isolated Unilateral Temporal Coloboma of the Lens","authors":"S. Suman, Arushi Kumar, H. U. Rathod","doi":"10.9734/or/2024/v19i1408","DOIUrl":"https://doi.org/10.9734/or/2024/v19i1408","url":null,"abstract":"Lens coloboma is a rare congenital anomaly that occurs due to failure of the foetal fissure to close completely causing an incomplete formation of the lens, so usually inferonasal. Temporal lens coloboma is extremely rare; reported cases were associated with ocular or systemic anomalies. We report a rare case of unilateral atypical temporal lens coloboma without any iris abnormality and posterior segment coloboma or any other ocular or systemic anomaly. \u0000An 18-year-old female presented with a gradually progressive painless diminution of vision in her left eye for two years. There was no history of trauma, and family history was non-contributory. The systemic examination was normal. Ocular examination revealed a vision of 6/6 in the right eye and 6/60 in the left eye improving to 6/24 with pinhole and unilateral atypical temporal coloboma of the crystalline lens in the left eye after dilatation. The rest of the anterior segment and fundus examination was normal. No abnormality was detected in the right eye. The best corrected visual acuity of 6/6 OD and 6/9 OS was achieved with spectacle correction at 6 months of follow-up. This case is a rare presentation of unilateral atypical coloboma located temporally without any iris abnormality and posterior segment coloboma or any other ocular or systemic anomaly. Early correction of refractive error and astigmatism results in good prognosis.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"31 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139389314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-20DOI: 10.9734/or/2023/v18i6406
Said Iferkhass, Mohcine El Mhadi
Docetaxel and paclitaxel are taxanes. They are widely used chemotherapeutic agents that have been shown to be effective for various types of solid malignancies. Docetaxel-related bilateral toxic cystoid macular edema (T-CME) has been reported as a rare and unusual adverse reaction. We report a case of 43-year women treated for breast cancer with docetaxel and developed T-CME. She was treated with two cycles of Docetaxel 150 mg, Pertuzumab 420 mg and Trastuzumab 360mg. Three days after 2nd cycle she complained of diminution of vision. Her both eye visual acuity was 20/200. Fundus examination showed macular edema which was confirmed with SD-OCT and fluorescein angiography. After fourth cycle Docetaxel was stopped by treating physician. CME was completely resolved by three months. Several studies suggest that a cumulative dose seems necessary for the onset of the toxic effect of this drug. To our knowledge, we report the first case of Docetaxel-induced T-CME occurring within less than 1 month, with a very low cumulative dose. This suggests that no cumulative dose is needed for macular edema to appear.
{"title":"Docetaxel-Induced Bilateral Cystoid Macular Edema with a Low Cumulative Dose: A Case Report","authors":"Said Iferkhass, Mohcine El Mhadi","doi":"10.9734/or/2023/v18i6406","DOIUrl":"https://doi.org/10.9734/or/2023/v18i6406","url":null,"abstract":"Docetaxel and paclitaxel are taxanes. They are widely used chemotherapeutic agents that have been shown to be effective for various types of solid malignancies. Docetaxel-related bilateral toxic cystoid macular edema (T-CME) has been reported as a rare and unusual adverse reaction. We report a case of 43-year women treated for breast cancer with docetaxel and developed T-CME. She was treated with two cycles of Docetaxel 150 mg, Pertuzumab 420 mg and Trastuzumab 360mg. Three days after 2nd cycle she complained of diminution of vision. Her both eye visual acuity was 20/200. Fundus examination showed macular edema which was confirmed with SD-OCT and fluorescein angiography. After fourth cycle Docetaxel was stopped by treating physician. CME was completely resolved by three months. Several studies suggest that a cumulative dose seems necessary for the onset of the toxic effect of this drug. To our knowledge, we report the first case of Docetaxel-induced T-CME occurring within less than 1 month, with a very low cumulative dose. This suggests that no cumulative dose is needed for macular edema to appear.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"146 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139258537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-20DOI: 10.9734/or/2023/v18i6405
Said Iferkhass, Mohcine El Mhadi
Introduction: Pot-streptococcal nummular keratitis is an interstitial keratitis characterized by large infiltrates in the cornea. Its mechanism is probably immuno-allergic. Patients and Methods: We report the first three cases of nummular keratitis related to a post-streptococcal infectious disease and we describe its clinical and tomographic aspect. Results: This is a new clinical entity, characterized by multiple rounded, whitish lesions 0.5 to 3 mm in diameter, located in the stroma. These plaques are made of small infiltrates arranged radially giving a “spoke wheel” appearance. With time, these infiltrates having a greater tendency to confluence and the plaques take on a “currency” appearance resembling those described by “Demmer”. Corneal sensitivity is preserved. Corneal optical coherence tomography (OCT) shows hyper-reflective lesions occupying the entire thickness of the stroma, with a "flying saucer" appearance respecting the corneal epithelium and endothelium with a tendency to confluence, particularly in the anterior stroma. Discussion: This keratitis can be unilateral or bilateral and associated with an inflammatory syndrome, a high titer of ASLO, and a streptococcal infection. Conclusion: Ophthalmologists faced with idiopathic nummular keratitis should consider post-streptococcal syndrome as a possible cause. A search for an increasing titer of ASLO and streptococcal infectious evidence establishes this association.
{"title":"Post-Streptococcal Nummular Keratitis: A New Clinical Entity","authors":"Said Iferkhass, Mohcine El Mhadi","doi":"10.9734/or/2023/v18i6405","DOIUrl":"https://doi.org/10.9734/or/2023/v18i6405","url":null,"abstract":"Introduction: Pot-streptococcal nummular keratitis is an interstitial keratitis characterized by large infiltrates in the cornea. Its mechanism is probably immuno-allergic. Patients and Methods: We report the first three cases of nummular keratitis related to a post-streptococcal infectious disease and we describe its clinical and tomographic aspect. Results: This is a new clinical entity, characterized by multiple rounded, whitish lesions 0.5 to 3 mm in diameter, located in the stroma. These plaques are made of small infiltrates arranged radially giving a “spoke wheel” appearance. With time, these infiltrates having a greater tendency to confluence and the plaques take on a “currency” appearance resembling those described by “Demmer”. Corneal sensitivity is preserved. Corneal optical coherence tomography (OCT) shows hyper-reflective lesions occupying the entire thickness of the stroma, with a \"flying saucer\" appearance respecting the corneal epithelium and endothelium with a tendency to confluence, particularly in the anterior stroma. Discussion: This keratitis can be unilateral or bilateral and associated with an inflammatory syndrome, a high titer of ASLO, and a streptococcal infection. Conclusion: Ophthalmologists faced with idiopathic nummular keratitis should consider post-streptococcal syndrome as a possible cause. A search for an increasing titer of ASLO and streptococcal infectious evidence establishes this association.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"16 1-2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139256938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-29DOI: 10.9734/or/2023/v18i4394
G. Demirci
Purpose: This research aimed to assess the underlying cause behind the in vitro acaricidal impact of proparacaine HCl on Demodex Folliculorum. Methods: In accordance with Gao's suggestion we epilated a total of 8 eyelashes 4 from the lower and 4 from the upper eyelid of a patient who applied for blepharitis symptoms to the ophthalmology clinic. We fixated 4 of these eyelashes with classical immersion oil and covered them with a coverslip. We wetted 4 of them with Proparacaine Hydrochloride 5 mg (0.5%) and painted them with Na-fluorescein, and covered them with a coverslip. Results: When we examined the eyelashes that were wetted with Proparacaine Hydrochloride under the light microscope there was no difference in mobility in the Demodex of the eyelashes at first 15 minutes. After 30 minutes we saw that the creamy lipid-like structure which is seen normally in the middle of the Demodex was saponified in Demodex. The other Demodex samples that were in the immersion oil were still alive. Conclusions: In this case report, we wanted to evaluate the reason for the acaricidal effect of Proparacaine Hydrochloride a local anesthetic agent on Demodex folliculorum. The idea came true while trying to demonstrate Na-fluorescein uptake of Demodex folliculorum under the microscope after using Proparacaine Hydrochloride5 mg (0.5%) to wet the Na-fluorescein paper and surprisingly we obtained these findings suggesting that it is a substance that may have an anti-acaricidal, anti-demodex effect potential to be a new player for treatment of demodicosis in the future.
{"title":"In Vitro Acaricidal Effect of Proparacaine HCl on Demodex Folliculorum","authors":"G. Demirci","doi":"10.9734/or/2023/v18i4394","DOIUrl":"https://doi.org/10.9734/or/2023/v18i4394","url":null,"abstract":"Purpose: This research aimed to assess the underlying cause behind the in vitro acaricidal impact of proparacaine HCl on Demodex Folliculorum. \u0000Methods: In accordance with Gao's suggestion we epilated a total of 8 eyelashes 4 from the lower and 4 from the upper eyelid of a patient who applied for blepharitis symptoms to the ophthalmology clinic. We fixated 4 of these eyelashes with classical immersion oil and covered them with a coverslip. We wetted 4 of them with Proparacaine Hydrochloride 5 mg (0.5%) and painted them with Na-fluorescein, and covered them with a coverslip. \u0000Results: When we examined the eyelashes that were wetted with Proparacaine Hydrochloride under the light microscope there was no difference in mobility in the Demodex of the eyelashes at first 15 minutes. After 30 minutes we saw that the creamy lipid-like structure which is seen normally in the middle of the Demodex was saponified in Demodex. The other Demodex samples that were in the immersion oil were still alive. \u0000Conclusions: In this case report, we wanted to evaluate the reason for the acaricidal effect of Proparacaine Hydrochloride a local anesthetic agent on Demodex folliculorum. The idea came true while trying to demonstrate Na-fluorescein uptake of Demodex folliculorum under the microscope after using Proparacaine Hydrochloride5 mg (0.5%) to wet the Na-fluorescein paper and surprisingly we obtained these findings suggesting that it is a substance that may have an anti-acaricidal, anti-demodex effect potential to be a new player for treatment of demodicosis in the future.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129947409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-22DOI: 10.9734/or/2023/v18i4393
Mohcine El Mhadi, A. E. Ouafi
Canalicular lacerations represent the first cause of intervention in lacrimal traumatology. They are observed in 16% of eyelid wounds and 20% of eyeball lesions. They can be caused by both penetrating and blunt trauma. Various materials have been used to stent the torn canaliculus in the past. Medical grade silicone, due to its inert nature and flexibility, has become the material of choice for tear stenting. We report the case of a lower canalicular laceration repaired using a flexible mono-canalicular probe with self-stabilizing meatic fixation, to describe the course of the intervention, as well as the advantages and tolerance of this technique. True mono-canalicular intubation, using a flexible mono-canalicular probe with self-stabilizing meatic fixation, has several advantages over other lacrimal intubation techniques. The placement of this probe is essential, to ensure the correct alignment of the anastomosis and the lacrimal lumen during the healing phase, to prevent fibrosis and stenosis after canalicular repair and thus to maintain permeability.
{"title":"Repair of an Inferior Canalicular Laceration using a Flexible Mono-Canalicular Probe with Self-Stabilizing Meatic Fixation","authors":"Mohcine El Mhadi, A. E. Ouafi","doi":"10.9734/or/2023/v18i4393","DOIUrl":"https://doi.org/10.9734/or/2023/v18i4393","url":null,"abstract":"Canalicular lacerations represent the first cause of intervention in lacrimal traumatology. They are observed in 16% of eyelid wounds and 20% of eyeball lesions. They can be caused by both penetrating and blunt trauma. Various materials have been used to stent the torn canaliculus in the past. Medical grade silicone, due to its inert nature and flexibility, has become the material of choice for tear stenting. We report the case of a lower canalicular laceration repaired using a flexible mono-canalicular probe with self-stabilizing meatic fixation, to describe the course of the intervention, as well as the advantages and tolerance of this technique. True mono-canalicular intubation, using a flexible mono-canalicular probe with self-stabilizing meatic fixation, has several advantages over other lacrimal intubation techniques. The placement of this probe is essential, to ensure the correct alignment of the anastomosis and the lacrimal lumen during the healing phase, to prevent fibrosis and stenosis after canalicular repair and thus to maintain permeability.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117149032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-24DOI: 10.9734/or/2023/v18i4392
Uzoamaka Donald Isdore, Chigozie John Ekenze, Lilian Chioma Owunna, T. Ogundeko, M. Ramyil, Nkiru Philomena Okoye, A. Bassi
Background: Plant parts have continued to attract attention in the global search for natural means of treatment of many diseases affecting humans and animals including glaucoma. Aims: The present study was designed to evaluate the effect of Aqueous seed extract of Dennettia tripetala (ASEDt) on the intraocular pressure (IOP) and the serum concentration of lipid parameters of Wistar strain albino rats (male and female). Methodology: This study was conducted in the Optometry and Anatomy department of Abia state University Uturu, Nigeria where a total of 37 males albino Wistar rats (12 weeks old), weighing 200 – 230g were used (12 for acute toxicity studies and 25 for the experiment proper) for a period of 35 days. The 25 rats were further divided into 5 groups (A-E) of 5 animals each according to various treatments A- No treatment, B-10mg/ml Cholesterol p.o, while C, D and E were treated with 10mg/ml Cholesterol p.o, plus administration of 200mg DT seed (aq) extract, 500mg DT seed (aq) extract and 0.5% timolol topically into the eye respectively. Intraocular pressure as well as the serum concentration of lipid parameters of the control group viz; Total cholesterol (TC), Triglycerides (TG), High density lipoprotein (HDL) and Low-Density Lipoprotein (LDL) was measured at day 1 (Baseline) 10 and 20 of experiment. Results: Topical administration of 200mg/kg and 500mg/kg DT seed (aq) extract caused a significant reduction of IOP in the rats. This reduction was higher with 500mg. Furthermore, both 500mg and 200mg (ASEDt)A caused a reduction in the levels of TC, TG, LDL and increased level of HDL. Conclusion: Aqueous seed extract of Dennettia tripetala caused a dose dependent reduction of intraocular pressure and ameliorated the serum concentration of lipid parameters in both male and female Wistar strain albino rats, thus suggesting that it could be beneficial in peculiar ocular, cardiovascular and public health care management.
{"title":"Effect of Orally Administered Dennettia tripetala (Pepper Fruit) (Aq) Extract on the Intraocular Pressure and Serum Concentration of Lipid Parameters of Wistar Strain Albino Rat","authors":"Uzoamaka Donald Isdore, Chigozie John Ekenze, Lilian Chioma Owunna, T. Ogundeko, M. Ramyil, Nkiru Philomena Okoye, A. Bassi","doi":"10.9734/or/2023/v18i4392","DOIUrl":"https://doi.org/10.9734/or/2023/v18i4392","url":null,"abstract":"Background: Plant parts have continued to attract attention in the global search for natural means of treatment of many diseases affecting humans and animals including glaucoma. \u0000Aims: The present study was designed to evaluate the effect of Aqueous seed extract of Dennettia tripetala (ASEDt) on the intraocular pressure (IOP) and the serum concentration of lipid parameters of Wistar strain albino rats (male and female). \u0000Methodology: This study was conducted in the Optometry and Anatomy department of Abia state University Uturu, Nigeria where a total of 37 males albino Wistar rats (12 weeks old), weighing 200 – 230g were used (12 for acute toxicity studies and 25 for the experiment proper) for a period of 35 days. The 25 rats were further divided into 5 groups (A-E) of 5 animals each according to various treatments A- No treatment, B-10mg/ml Cholesterol p.o, while C, D and E were treated with 10mg/ml Cholesterol p.o, plus administration of 200mg DT seed (aq) extract, 500mg DT seed (aq) extract and 0.5% timolol topically into the eye respectively. Intraocular pressure as well as the serum concentration of lipid parameters of the control group viz; Total cholesterol (TC), Triglycerides (TG), High density lipoprotein (HDL) and Low-Density Lipoprotein (LDL) was measured at day 1 (Baseline) 10 and 20 of experiment. \u0000Results: Topical administration of 200mg/kg and 500mg/kg DT seed (aq) extract caused a significant reduction of IOP in the rats. This reduction was higher with 500mg. Furthermore, both 500mg and 200mg (ASEDt)A caused a reduction in the levels of TC, TG, LDL and increased level of HDL. \u0000Conclusion: Aqueous seed extract of Dennettia tripetala caused a dose dependent reduction of intraocular pressure and ameliorated the serum concentration of lipid parameters in both male and female Wistar strain albino rats, thus suggesting that it could be beneficial in peculiar ocular, cardiovascular and public health care management.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114620016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-05DOI: 10.9734/or/2023/v18i4391
G. Nathaniel, U. Eze
Glaucoma management is as challenging as diagnosing it. Achieving sustained intraocular pressure that will retard the progression of the disease is the principal objective of its management. Many a times, this requires a combination of antiglaucoma medications, Lasers and surgery. No doubt, medical therapy is usually the mainstay of glaucoma management but in some cases, it fails to adequately control the intraocular pressure. The very effective surgical interventions for glaucoma depend on the health of the conjunctiva to achieve their success. So, meticulous evaluation of the conjunctiva is one of the indispensable preoperative considerations before deciding on any conjunctiva-dependent surgery. In addition, in managing any patient with ocular problem who also has glaucoma, it is imperative that the possibility of future surgery involving the conjunctiva must be considered. Therefore, the conjunctiva of all glaucoma patients must be handled with care.
{"title":"Preserving Conjunctiva, the ‘Real Estate’ of Glaucoma Surgeons","authors":"G. Nathaniel, U. Eze","doi":"10.9734/or/2023/v18i4391","DOIUrl":"https://doi.org/10.9734/or/2023/v18i4391","url":null,"abstract":"Glaucoma management is as challenging as diagnosing it. Achieving sustained intraocular pressure that will retard the progression of the disease is the principal objective of its management. Many a times, this requires a combination of antiglaucoma medications, Lasers and surgery. No doubt, medical therapy is usually the mainstay of glaucoma management but in some cases, it fails to adequately control the intraocular pressure. The very effective surgical interventions for glaucoma depend on the health of the conjunctiva to achieve their success. So, meticulous evaluation of the conjunctiva is one of the indispensable preoperative considerations before deciding on any conjunctiva-dependent surgery. In addition, in managing any patient with ocular problem who also has glaucoma, it is imperative that the possibility of future surgery involving the conjunctiva must be considered. Therefore, the conjunctiva of all glaucoma patients must be handled with care.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131308417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-27DOI: 10.9734/or/2023/v18i4390
Alfin Ruth Jeneral
Aims: The study aimed to assess the post-operative presenting visual acuity (PVA) and best-corrected visual acuity (BCVA) from six weeks and above post-surgery, of patients operated for age-related cataract with biometry-calculated IOL power and available IOL power implantation, in two hospitals in Jos, Nigeria. Study Design: Retrospective cross-sectional survey. Place and Duration of Study: Eye units of two mission Hospitals in Jos namely; Bingham University Teaching Hospital and the Faith Alive foundation Hospital, between June and August 2021. Methodology: Patients aged 40 years and above, who had undergone surgery for age-related cataract in the preceding 18 months in two hospitals in Jos and were six weeks or more post-surgery were consecutively enrolled into the study, after obtaining informed consent. Socio-demographic data and surgical history were obtained from patients and their surgical records. The PVA and BCVA were assessed and categorized based on World Health Organization guidelines. Results: A total of 87 patients were examined within the study period. Post-operative PVA was good (≥6/18) in 32 (36.8%), borderline (<6/18-6/60) in 41 (47.1%) and poor (<6/60) in 14 (16.1%) participants. After refraction, the proportion of good outcomes increased to 78.2% with only 8.1% of outcomes remaining poor. Biometry-calculated IOL power and available IOL power use did not significantly influence visual outcome (P=.645 and P=.146 for PVA and BCVA respectively). Conclusion: Majority of participants had post-operative PVA in the borderline category with residual uncorrected refractive error as the principal cause. Regardless of the IOL power implanted, surgery for age-related cataract enhanced patients’ vision. This study has shown that the presence of biometry is a guarantee of refractive success. Hence, refractive outcome audits are essential.
{"title":"Clinical Outcomes of Surgery for Age-related Cataract with Intraocular Lens Implantation in Two Hospitals in North-Central Nigeria","authors":"Alfin Ruth Jeneral","doi":"10.9734/or/2023/v18i4390","DOIUrl":"https://doi.org/10.9734/or/2023/v18i4390","url":null,"abstract":"Aims: The study aimed to assess the post-operative presenting visual acuity (PVA) and best-corrected visual acuity (BCVA) from six weeks and above post-surgery, of patients operated for age-related cataract with biometry-calculated IOL power and available IOL power implantation, in two hospitals in Jos, Nigeria. \u0000Study Design: Retrospective cross-sectional survey. \u0000Place and Duration of Study: Eye units of two mission Hospitals in Jos namely; Bingham University Teaching Hospital and the Faith Alive foundation Hospital, between June and August 2021. \u0000Methodology: Patients aged 40 years and above, who had undergone surgery for age-related cataract in the preceding 18 months in two hospitals in Jos and were six weeks or more post-surgery were consecutively enrolled into the study, after obtaining informed consent. Socio-demographic data and surgical history were obtained from patients and their surgical records. The PVA and BCVA were assessed and categorized based on World Health Organization guidelines. \u0000Results: A total of 87 patients were examined within the study period. Post-operative PVA was good (≥6/18) in 32 (36.8%), borderline (<6/18-6/60) in 41 (47.1%) and poor (<6/60) in 14 (16.1%) participants. After refraction, the proportion of good outcomes increased to 78.2% with only 8.1% of outcomes remaining poor. Biometry-calculated IOL power and available IOL power use did not significantly influence visual outcome (P=.645 and P=.146 for PVA and BCVA respectively). \u0000Conclusion: Majority of participants had post-operative PVA in the borderline category with residual uncorrected refractive error as the principal cause. Regardless of the IOL power implanted, surgery for age-related cataract enhanced patients’ vision. This study has shown that the presence of biometry is a guarantee of refractive success. Hence, refractive outcome audits are essential.","PeriodicalId":287685,"journal":{"name":"Ophthalmology Research: An International Journal","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121845977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：