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Allergy to Insulin Analogs in Gestational Diabetes 妊娠期糖尿病患者对胰岛素类似物过敏
Pub Date : 2017-06-30 DOI: 10.4197/MED.24-2.6
K. Ghamri
Since human recombinant insulin preparations has been introduced in medicine, allergies to insulin have rarely been reported, especially in pregnant women, who experience immune system alterations that are due to physiologic changes that occur during pregnancy. We describe a 41-year old woman who developed gestational diabetes during the second trimester and was initially treated with insulin aspart and detemir. She complained of itching, redness and a burning sensation at insulin injection sites a few weeks after administration of both insulin types. This warranted cessation of her current insulin regimen and switching to Humulin R and Humulin N due to the unavailability of insulin lispro in the hospital. In addition, patient couldn’t afford buying it from outside the hospital. Her serum glucose was well controlled on this insulin regimen, and no allergic reaction was reported by the patient. Insulin allergy is an unusual finding in pregnancy, which can be managed by switching treatment regimens.
自从人重组胰岛素制剂被引入医学以来,对胰岛素过敏的报道很少,特别是在孕妇中,由于怀孕期间发生的生理变化而经历免疫系统改变。我们描述了一位41岁的女性,她在妊娠中期患上了妊娠糖尿病,最初接受了胰岛素分离和地特米的治疗。在注射两种胰岛素几周后,她抱怨胰岛素注射部位发痒、发红和烧灼感。这保证了她目前的胰岛素治疗方案的停止,并切换到Humulin R和Humulin N,因为医院没有胰岛素lispro。此外,病人也负担不起从医院外购买的费用。在胰岛素治疗方案下,患者血糖控制良好,无过敏反应。胰岛素过敏在怀孕期间是一种不寻常的发现,可以通过改变治疗方案来控制。
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引用次数: 0
Middle Ear Ventilation Tube in Patients with Cleft Palate at King Abdulaziz University Hospital 阿卜杜勒阿齐兹国王大学医院腭裂患者的中耳通气管
Pub Date : 2017-06-30 DOI: 10.4197/med.24-2.4
Talal A. Alkhatib, Y. Jamal, Abdulaziz Alghamdi, B. Simbawa, Yahya H. Ghunaim, L. Bukhari
Citation AlKhatib TA, Jamal YS, Alghamdi AH, Simbawa BM, Ghunaim YH, Bukhari LA. Middle ear ventilation tube in patients with cleft palate at King Abdulaziz University Hospital. JKAU Med Sci 2017; 24 (2): 29-32 DOI: 10.4197/Med. 24.2.4 Abstract This study aims to determine the number of patients with cleft palate requiring treatment for otitis media with eff usion. Speech and hearing assessments were also considered. We conducted a retrospective study from January, 2005 through December, 2012 at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, on otitis media with eff usion in patients with cleft palate. We reviewed patients’ medical records to determine the number requiring treatment for otitis media with eff usion, the timing of middle ear ventilation tube insertion, the number of tubes to be inserted, and the type of tube to be used. Data were collected from the patients’ medical records. Ethical approval was obtained by the university’s ethical committee. A total of 101 patients were diagnosed with cleft palate spectrum. Among them, we found that only 12 patients had a hearing assessment and tympanograms performed followed by middle ear ventilation tube insertion. This may indicate the need for more involvement of the otolaryngologists in the multidisciplinary clinical teams for evaluating cleft palate patients .
AlKhatib TA, Jamal YS, Alghamdi AH, Simbawa BM, Ghunaim YH, Bukhari LA。阿卜杜勒阿齐兹国王大学医院腭裂患者的中耳通气管。中华医学会医学杂志2017;24 (2): 29-32 DOI: 10.4197/Med。24.2.4摘要本研究旨在了解腭裂合并中耳炎需要治疗的患者数量。语言和听力评估也被考虑在内。我们于2005年1月至2012年12月在沙特阿拉伯吉达的阿卜杜勒阿齐兹国王大学医院对腭裂患者中耳炎合并颅内出血进行了回顾性研究。我们回顾了患者的医疗记录,以确定需要治疗中耳炎合并鼻塞的人数、中耳通气管插入的时间、要插入的管的数量和使用的管的类型。数据是从病人的医疗记录中收集的。获得了大学伦理委员会的伦理批准。共有101例患者被诊断为腭裂谱系。其中,我们发现只有12例患者进行了听力评估和鼓室造影,然后插入中耳通气管。这可能表明需要更多的耳鼻喉科医生参与多学科临床团队评估腭裂患者。
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引用次数: 0
Gastric Histopathology of Chronic Gastritis in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Local Experience 肥胖患者行腹腔镜袖胃切除术后慢性胃炎的胃组织病理学研究
Pub Date : 2017-06-30 DOI: 10.4197/MED.24-2.2
M. Alturkustani
A retrospective review was conducted using the database at King Abdulaziz University Hospital, to determine the most common cause of chronic gastritis among obese individuals. One hundred and thirty-one specimens were examined, obtained from patients who had laparoscopic sleeve gastrectomy and diagnosed with chronic gastritis. Helicobacter pylori was detected in 15 cases only. The most common diagnosis was “Chronic inactive gastritis without Helicobacter pylori infection” in 57 (43.50%) cases, then “Chronic gastritis with lymphoid follicular hyperplasia” in 54 (41.20%) cases, and lastly “Chronic active gastritis” in the remaining 20 (15.20%) Cases. The low incidence of Helicobacter pylori infection even in cases of gastritis with lymphoid follicular hyperplasia support the existence of the new proposed entity (i.e., obesity-related gastritis). Biopsy specimens for cases diagnosed as chronic gastritis were used as control group to confirm the appropriate rate of detecting Helicobacter pylori organisms by morphological examination in the same laboratory. In these biopsies, Helicobacter pylori was present in (50.70%), and reactive follicular hyperplasia was detected in (6%) of total controls.
利用阿卜杜勒阿齐兹国王大学医院的数据库进行了一项回顾性研究,以确定肥胖个体中慢性胃炎的最常见原因。我们检查了131个标本,这些标本来自于经腹腔镜袖胃切除术并诊断为慢性胃炎的患者。仅15例检出幽门螺杆菌。诊断以“慢性非活动性胃炎,无幽门螺杆菌感染”最多,57例(43.50%),其次为“慢性胃炎伴淋巴滤泡增生”54例(41.20%),最后为“慢性活动性胃炎”20例(15.20%)。即使在伴有淋巴滤泡增生的胃炎病例中,幽门螺杆菌感染的发生率也很低,这支持了新提出的实体(即肥胖相关性胃炎)的存在。以诊断为慢性胃炎病例的活检标本为对照组,在同一实验室进行形态学检查,确定幽门螺杆菌的适宜检出率。在这些活组织检查中,幽门螺杆菌(50.70%)存在,反应性卵泡增生(6%)在总对照组中检测到。
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引用次数: 0
Validation of a Smartphone Application for Assessment of Risk of Venous Thromboembolism in Obstetrics and Gynecology 用于评估产科和妇科静脉血栓栓塞风险的智能手机应用程序的验证
Pub Date : 2017-06-30 DOI: 10.4197/med.24-2.5
Galila F. Zaher, S. Adam
Venous thromboembolism is a serious but potentially preventable condition. However, morbidity and mortality occur due to lack of thrombo-prophylaxis. Obstetrics and gynecology patients are at risk for developing venous thromboembolism. To improve adherence to thromboprophylaxis in this patient population, we developed a smart phone clinical decision support system designed to assess risk score and recommend thromboprophylaxis. Clinical data were collected by review of electronic medical charts. The risk score and thromboprophylaxis recommendations were calculated for each patient by clinical decision support system and by an expert hematologist and results were compared for correlation. We hypothesize that the system is a valid tool for risk assessment in obstetrics and gynecology patients. A total of 188 female patients admitted at King Abdulaziz University Hospital between December 2015 and March 2016 were included. One hundred and sixteen were gynecology, and 72 were obstetric patients with a mean age of 40.7 (± 12.8). The risk score obtained by the system showed a strong correlation with that of the expert hematologist’s opinion (r = 83%). The clinical decision support system showed a good correlation for thromboprophylaxis decision as well. Accessibility and ease of use of clinical decision support system can improve the clinical outcome of hospitalized patients.
静脉血栓栓塞是一种严重但有可能预防的疾病。然而,发病率和死亡率的发生是由于缺乏血栓预防。妇产科患者有发生静脉血栓栓塞的危险。为了提高患者对血栓预防的依从性,我们开发了一个智能手机临床决策支持系统,旨在评估风险评分并推荐血栓预防。通过查阅电子病历收集临床资料。通过临床决策支持系统和血液学专家计算每位患者的风险评分和血栓预防建议,并比较结果的相关性。我们假设该系统是妇产科患者风险评估的有效工具。该研究包括2015年12月至2016年3月期间在阿卜杜勒阿齐兹国王大学医院住院的188名女性患者。妇科116例,产科72例,平均年龄40.7(±12.8)岁。系统获得的风险评分与血液学专家的意见有很强的相关性(r = 83%)。临床决策支持系统与血栓预防决策也有良好的相关性。临床决策支持系统的可及性和易用性可以提高住院患者的临床疗效。
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引用次数: 1
Evaluation of Nutritional Status for Some Sensitive Sets and its Relationship to Natural Antioxidants 某些敏感集的营养状况评价及其与天然抗氧化剂的关系
Pub Date : 2017-03-31 DOI: 10.4197/med.24-1.1
R. Sami, E. Khojah, E. Elgarni, N. Benajiba
Citation Sami RA, Khojah EY, Elgarni EA, Benajiba N. Evaluation of nutritional status for some sensitive sets and its relationship to natural antioxidants. JKAU Med Sci 2017; 24 (1): 1-9. DOI: 10.4197/Med. 24.1.1 Abstract There exists a need to get the knowledge of natural antioxidants’ sources as a result of several factors; perhaps most notably is the change in our lifestyle. Although modern life has become easier and more comfortable, it harms us in diff erent ways. So, we should look for the best ways to support our health. Although our body manufactures antioxidants, we need additional quantities for protecting the body. Natural antioxidants are found in fresh vegetables, fruits, seafood and some nuts. Sport is essential for our health. The short period sports could increase the antioxidant production quickly too. Groups of children, adolescents, adults and elderly have been tested. A selfadministered questionnaire asking about socio-demographic data, various forms of activities, dietary intakes and habits was used for data collection. The elementary schoolchildren were interviewed by structured interview to gather information. Therefore, there is a necessity to develop a nutrition education program in order to change lifestyle habits and avoid the negative health consequences.
Sami RA, Khojah EY, Elgarni EA, Benajiba N.营养状况的评价及其与天然抗氧化剂的关系。中华医学会医学杂志2017;24(1): 1-9。DOI: 10.4197 /地中海。24.1.1摘要由于以下几个因素,有必要了解天然抗氧化剂的来源;也许最显著的是我们生活方式的改变。虽然现代生活变得更容易,更舒适,但它在不同方面伤害了我们。所以,我们应该寻找最好的方法来维持我们的健康。虽然我们的身体会制造抗氧化剂,但我们需要额外的量来保护身体。新鲜蔬菜、水果、海鲜和一些坚果中含有天然抗氧化剂。运动对我们的健康是必不可少的。短时间的运动也能快速增加抗氧化剂的产生。对儿童、青少年、成年人和老年人进行了测试。一份关于社会人口统计数据、各种形式的活动、饮食摄入量和习惯的自我管理问卷用于数据收集。采用结构化访谈法对小学生进行访谈,收集信息。因此,有必要制定营养教育计划,以改变生活习惯,避免对健康的负面影响。
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引用次数: 7
Acquired Tracheoesophageal Fistula in Infancy and Childhood 婴幼儿获得性气管食管瘘
Pub Date : 2017-03-31 DOI: 10.4197/MED.24-2.1
O. Bawazir
Acquired tracheoesophageal fi stula in infancy and childhood is a very rare condition with no epidemiological data available in the literature for it. There is a huge similarity of the condition to the congenital acquired tracheoesophageal fi stula. Management of children with this condition can be diffi cult with a high risk of complication. To provide a successful management of the condition, there are some points that need to be addressed about acquired tracheoesophageal fi stula. In this report, the author presents fourteen different cases of acquired TEF with diff erent etiologies over 11 years (2006 - January 2017) who were referred for management to tertiary care hospital in Jeddah, KSA; all patients had removal of the foreign body followed bysurgical repair of the fi stula. This report describes the detailed steps of our surgical repair, including the approach to the fi stula and the type of repair pointing out the importance of removal of the scar tissue anduse of interposition vascular grafts with suture lines separation. This study presents our experience in management and surgical repair of the acquired tracheoesophageal fistula.
婴儿期和儿童期获得性气管食管瘘是一种非常罕见的疾病,文献中没有流行病学资料。这种情况与先天性获得性气管食管瘘有很大的相似之处。患有这种疾病的儿童的治疗可能很困难,并发症的风险很高。为了提供一个成功的治疗条件,有一些问题需要解决的获得性气管食管瘘。在本报告中,作者介绍了11年来(2006年至2017年1月)14例不同病因的获得性TEF病例,这些病例被转介到沙特阿拉伯吉达的三级保健医院进行管理;所有的患者都切除了异物,然后手术修复了瘘管。这篇报道描述了我们手术修复的详细步骤,包括瘘口的入路和修复的类型,指出了去除疤痕组织和使用缝线分离的间置血管移植物的重要性。本文介绍了我们在后天性气管食管瘘的治疗和手术修复方面的经验。
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引用次数: 0
Successful Non-Surgical Intervention for Massive Gastric Distention due to Malignant Duodenal Obstruction 恶性十二指肠梗阻致胃膨胀的成功非手术治疗
Pub Date : 2017-03-31 DOI: 10.4197/med.24-1.6
Yazeed A. Khojah
Citation Khojah YA. Successful non-surgical intervention for massive gastric distention due to malignant duodenal obstruction. JKAU Med Sci 2017; 24 (1): 49-52. DOI: 10.4197/Med. 24.1.6 Abstract Gastroduodenal obstruction in pancreatic cancer is common and sometimes challenging to treat. A 35-year-old man with advanced pancreatic cancer receiving palliative chemotherapy presented with worsening abdominal pain, nausea, vomiting and increased abdominal girth. Computed tomography scan of the abdomen revealed signifi cant malignant duodenal obstruction with massive gastric distention. A non-surgical endoscopic intervention with placement of a self-expanding metallic duodenal stent successfully relieved the obstruction and ameliorated symptoms. The patient was able to resume eating normally again. Gastrointestinal stenting is a less invasive and eff ective alternative to surgical gastrojejunostomy. Stent placement as a palliative treatment for patients with malignant duodenal obstruction and massive gastric distention may be considered as a fi rst line treatment for such patients.
引文:Khojah YA。恶性十二指肠梗阻致胃膨胀的非手术治疗成功。中华医学会医学杂志2017;24(1): 49-52。DOI: 10.4197 /地中海。24.1.6摘要胰腺癌胃十二指肠梗阻较为常见,有时治疗难度较大。一位35岁晚期胰腺癌患者接受姑息性化疗,表现为腹痛加重、恶心、呕吐和腹围增大。腹部电脑断层扫描显示明显的恶性十二指肠梗阻,并伴有大量胃胀。非手术内镜下放置自膨胀金属十二指肠支架成功缓解了阻塞并改善了症状。病人又能正常进食了。胃肠支架植入术是一种微创、有效的替代手术胃空肠吻合术的方法。对于恶性十二指肠梗阻和胃膨胀的患者,支架置入术作为姑息性治疗可以考虑作为这类患者的一线治疗。
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引用次数: 0
Bacterial Vaginosis Awareness Among Pediatric and Adolescent Age Groups in Saudi Arabia 沙特阿拉伯儿童和青少年年龄段对细菌性阴道病的认识
Pub Date : 2017-03-31 DOI: 10.4197/MED.24-1.4
Ettedal A. Aljahdali
Bacterial vaginosis has turned into one of the most common medical condition among women here in Saudi Arabia. Several contributing factors, including the lack of knowledge have been affi liated with this infection and yet the cause remains uncertain. The aim of this study is to determine the level of population awareness regarding bacterial vaginosis both in pediatric and adolescent age groups. It also seeks to evaluate the relationship between the outlined causative factors and bacterial vaginosis. A cross sectional descriptive study was conducted using a self-developed questionnaire and was distributed among the participants (adolescent girls, mothers and non-mothers) over a period of four months from December 2013 until March 2014 at King Abdulaziz Hospital, Jeddah, Saudi Arabia. The study revealed that a remarkable number of the mother respondents demonstrated awareness on bacterial vaginosis in pre-pubertal and adolescent age group (289, 96.98%). The sample of population under the pre-pubertal age group (122, 40.94%) had higher incidence rates of bacterial vaginosis in comparison with the adolescents and non-mothers (17, 6.25%). Advanced research is required to better understand the pathological and physiological mechanisms of bacterial vaginosis. Continuing studies are necessary to enhance the accuracy of its diagnosis and modalities of treatment.
细菌性阴道病已经成为沙特阿拉伯女性最常见的疾病之一。包括缺乏知识在内的几个因素与这种感染有关,但原因仍不确定。本研究的目的是确定儿童和青少年年龄组对细菌性阴道病的认识水平。它还试图评估概述的致病因素和细菌性阴道病之间的关系。在2013年12月至2014年3月的四个月期间,在沙特阿拉伯吉达的阿卜杜勒阿齐兹国王医院,使用自行编制的问卷进行了一项横断面描述性研究,并在参与者(少女、母亲和非母亲)中分发。研究发现,在青春期前和青少年年龄段,有289名母亲对细菌性阴道病有一定的认识(占96.98%)。青春期前人群(122例,40.94%)细菌性阴道病的发病率高于青少年和非母亲人群(17例,6.25%)。进一步的研究需要更好地了解细菌性阴道病的病理和生理机制。有必要继续研究以提高其诊断和治疗方式的准确性。
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引用次数: 0
Examiners' and Candidates' Perspectives on the First Performance-Based Assessment of the Saudi National Anesthesiology Board Final Exam 审查员和考生对沙特国家麻醉学委员会期末考试第一次基于成绩的评估的看法
Pub Date : 2017-03-31 DOI: 10.4197/med.24-1.2
A. Boker
Citation Boker AM. Examiners' and candidates' perspectives on the fi rst performancebased assessment of the Saudi National Anesthesiology Board fi nal exam. JKAU Med Sci 2017; 24 (1): 11-21. DOI: 10.4197/Med. 24.1.2 Abstract The Saudi Board of Anesthesia introduced a performance-based, objective, structured, clinical examination to supplement key and missing components in the traditional fi nal board exam. This study aims to describe briefl y the development, implementation and evaluation of the fi rst high stake Saudi Board of Anesthesia exam after incorporation of objective, structured, clinical examination according to the participants’ perspectives. After implementation of performance-based exams for the fi rst time, a questionnaire was distributed to the candidates and examiners to explore their perception of the exam. Twenty-three candidates and 20 examiners participated in the Saudi Board exam for anesthesia residency held on November 2015. The candidates as well as the examiners were very satisfi ed with the explanation of the exam process before the exam taking, the time allotted for the active stations as well as the organization and fairness of the exam with no signifi cant diff erence between males and females. In conclusion, the objective, structured, clinical examination is well perceived by the examinees as a fair and acceptable assessment tool in the fi nal exam of the Saudi Board of Anesthesia. We conclude that objective, structured, clinical examination is recommended to be used by other Saudi high stake exams.
引用本文:Boker AM。审查员和考生对沙特国家麻醉学委员会期末考试第一次基于绩效的评估的观点。中华医学会医学杂志2017;24(1): 11-21。DOI: 10.4197 /地中海。24.1.2摘要沙特麻醉委员会引入了一种基于绩效的、客观的、结构化的临床考试,以补充传统的委员会期末考试中的重点和缺失部分。本研究旨在根据参与者的观点,在纳入客观、结构化、临床检查后,简要描述第一次高风险沙特麻醉委员会考试的发展、实施和评估。在首次实施绩效考试后,我们向考生和考官发放了一份调查问卷,以了解他们对考试的看法。2015年11月,23名考生和20名考官参加了沙特委员会的麻醉住院医师考试。考生和主考人员对考前对考试过程的讲解、活动站的时间分配、考试的组织性和公正性都非常满意,男女之间没有显著差异。总之,在沙特麻醉委员会的期末考试中,客观、结构化的临床检查被考生很好地认为是一种公平和可接受的评估工具。我们的结论是,客观的,结构化的,临床检查被推荐用于其他沙特高风险检查。
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引用次数: 1
Effect of Different Saudi Honey Types Mixed with Natural Substances on Some Bacterial Strains 不同沙特蜂蜜与天然物质混合对某些细菌的影响
Pub Date : 2017-03-31 DOI: 10.4197/MED.24-1.3
F. Nashawi, H. Abdullah, N. Khalifa, I. Al-Zahrani, A. Al-Ghamdi
To evaluate the antibacterial eff ects of three types of Saudi honey (Feghra, Sider and Natural honey) alone and mixed with ginger or lemon in comparison to Manuka honey as a potential natural antibacterial agent. Saudi honeys were evaluated against five types of bacterial strains; Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Haemophilus influenzae and Streptococcus pneumoniae. Chocolate agars were prepared first with different concentrations of each type of honey, and then with specific concentrations either of ginger or lemon added to honey. Bacterial species were inoculated on each agar and incubated at 37oC in a CO2 incubator overnight. Significant differences were found between diff erent types of honey and different concentrations of the same honey on bacterial growth. There are no significant differences and synergistic effects when adding ginger to diff erent honey types. Addition of lemon show significant differences and good synergistic effects against all tested bacterial species except Klebsiella pneumoniae and Staphylococcus aureus at 15 and 20% honey concentration. In conclusion, antibacterial effects of different types of honey are type and concentration dependent. Adding lemon to the different types of honey changes the pH and acidity and increases the honey’s antibacterial effect.
评价三种沙特蜂蜜(费格拉蜂蜜、西德蜂蜜和天然蜂蜜)单独使用以及与生姜或柠檬混合使用的抗菌效果,并与麦卢卡蜂蜜作为潜在的天然抗菌剂进行比较。对沙特蜂蜜进行了5种细菌菌株的鉴定;肺炎克雷伯菌、金黄色葡萄球菌、铜绿假单胞菌、流感嗜血杆菌和肺炎链球菌。首先用不同浓度的蜂蜜制作巧克力琼脂,然后在蜂蜜中加入特定浓度的姜或柠檬。将菌种接种于每种琼脂上,在37℃的CO2培养箱中培养过夜。不同种类的蜂蜜和不同浓度的蜂蜜对细菌生长有显著差异。在不同蜂蜜中添加生姜,无显著差异和增效作用。在蜂蜜浓度为15%和20%时,除肺炎克雷伯菌和金黄色葡萄球菌外,柠檬的添加量差异显著且具有良好的增效作用。综上所述,不同类型蜂蜜的抑菌作用具有类型和浓度依赖性。在不同种类的蜂蜜中加入柠檬可以改变pH值和酸度,增加蜂蜜的抗菌效果。
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引用次数: 1
期刊
Journal of King Abdulaziz University-medical Sciences
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