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The Prevalences, Risk Factors, and Lengths of Hospital Stay of Patients with Suspected Lower Limb Deep Venous Thrombosis in the King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia 沙特阿拉伯吉达阿卜杜勒阿齐兹国王大学医院疑似下肢深静脉血栓患者的患病率、危险因素和住院时间
Pub Date : 2020-06-30 DOI: 10.4197/MED.27-1.5
A. Abduljabbar, R. Ahmad, Basem H. Bahakeem, Yahea A. Alzahrani, N. Batawil, K. Bahubaishi, R. Filfilan, Mohammad A Wazzan
The prediction of risks and the predisposing factors that lead to the formation of blood clots, using appropriate clinical examination is crucial to the treatment of thrombosis. It is important to estimate the length of hospital stays of those clinically suspected of thrombosis. This study evaluated the prevalence of lower-limb deep venous thrombosis and its associated risk factors to predict the lengths of hospital stays of the patients. The 1,201 medical records of patients, aged 16 to 98 years, were collected from the King Abdulaziz University Hospital from January 2013 to December 2015. Their thrombosis were evaluated using a doppler ultrasound and a sonographic assessment. The results of the study revealed the prevalence of thrombosis among 18.9% of the elderly patients, 14.5% in patients with diabetes mellitus, 13.3% in those with hypertension, 17.8% in bed-ridden patients, 12.2% in patients with ischemic heart disease, 20.5% in patients with breast cancer, 5.1% in pregnant women, and 10% in obese patients. No deep venous thrombosis was reported in patients with history of heart failure. Having breast cancer and being old were the major risk factors that were identified among the patients with lower limb deep venous thrombosis.
预测导致血栓形成的危险因素和易感因素,采用适当的临床检查对血栓形成的治疗至关重要。估计临床怀疑血栓形成的住院时间是很重要的。本研究评估下肢深静脉血栓形成的患病率及其相关危险因素,以预测患者的住院时间。2013年1月至2015年12月从阿卜杜勒阿齐兹国王大学医院收集了1,201例患者的医疗记录,年龄在16至98岁之间。用多普勒超声和超声检查评估血栓形成。研究结果显示,老年患者血栓发生率为18.9%,糖尿病患者为14.5%,高血压患者为13.3%,卧床患者为17.8%,缺血性心脏病患者为12.2%,乳腺癌患者为20.5%,孕妇为5.1%,肥胖患者为10%。有心力衰竭病史的患者未见深静脉血栓形成。患乳腺癌和老年是下肢深静脉血栓形成的主要危险因素。
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引用次数: 2
Radiotherapy-induced Acute Carotid Blowout Syndrome in Base of Tongue Cancer 舌癌基底放射治疗引起的急性颈动脉爆裂综合征
Pub Date : 2020-06-30 DOI: 10.4197/MED.27-1.10
Abdulrahman Almazrooa
Carotid blowout syndrome is an uncommon and fatal medical emergency in patients with head and neck cancer. Tumor progression, previous surgery, and radiotherapy on the head and the neck regions are some of the predisposing factors that affect its presentation. An early suspicion of a carotid blowout syndrome allows early safety measurements to prevent catastrophic events. A 71-year-old man with advanced base of tongue cancer was presented with a self- limiting oral bleeding 18 months after receiving chemoradiotherapy. Fiberoptic laryngoscopy and contrast-enhanced computed tomography revealed the presence of edema of the hypopharynx and thyroid cartilage fracture and necrosis. The patient developed acute oral hemorrhage. Surgical intervention was insufficient to achieve hemostasis. The carotid angiography revealed a common carotid artery rupture, and a covered stent was placed endovascularly. The covered stent placement was enough to stop the bleeding. However, the patient died from perioperative complications. Experience is necessary for the early detection and prevention of a carotid blowout syndrome.
颈动脉爆裂综合征是头颈癌患者中一种罕见且致命的急症。肿瘤进展、既往手术和头颈部放疗是影响其表现的一些易感因素。对颈动脉爆裂综合征的早期怀疑可以使早期的安全措施防止灾难性事件的发生。一位71岁晚期舌底癌患者在接受放化疗18个月后出现自限性口腔出血。纤维喉镜和增强计算机断层扫描显示下咽水肿和甲状腺软骨骨折和坏死。病人出现急性口腔出血。手术干预不足以止血。颈动脉造影显示颈总动脉破裂,血管内放置覆盖支架。覆盖支架的放置足以止血。然而,患者死于围手术期并发症。经验对于颈动脉爆裂综合征的早期发现和预防是必要的。
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引用次数: 0
Male Circumcision: A Practice Survey from Saudi Arabia 男性包皮环切术:来自沙特阿拉伯的实践调查
Pub Date : 2019-12-31 DOI: 10.4197/med.26-2.5
O. Bawazir, H. Sembawa
The study aims to evaluate the various techniques used to perform circumcision in Saudi Arabia. In September 2018, this cross-sectional survey was performed. A questionnaire was sent to all pediatric surgery units across the Kingdom. The responses to the questionnaire were analyzed and categorized. A total of 176 questionnaires were send and more than half (56.3%) of the practitioners filled the questioners, 62 (63%) were consultants, 19 (19%) were specialists and 19 (19%) were trainee in pediatric surgery fellowship program. Circumcisions were performed in Maternity and Children hospitals (32.3%), tertiary hospitals (32.3%), private hospitals (16%) and in general or academic hospitals (19%). The most commonly used method for circumcision was Gomco clamp (n = 39; 39.6%) followed by Plastibell (n = 30; 30%) and bone cutter (n = 25; 25.4%). The optimal time for circumcision was in neonatal period. Eighty-six percent of the surgeons agree that 2.5 to 5 kg is the optimal weight for the baby to do circumcision. In Saudi Arabia circumcision is a religious practice done for every Muslim male. It should be done by trained medical practitioner and circumcision done by non-medical personal should be avoided. Circumcision should be performed in the neonatal period and attention should be given to analgesia.
这项研究旨在评估在沙特阿拉伯实施割礼的各种技术。2018年9月,进行了这项横断面调查。向王国所有儿科外科单位发送了一份调查问卷。对问卷的回答进行分析和分类。共发放问卷176份,超过半数(56.3%)的执业医师填写了问卷,62名(63%)的执业医师填写了问卷,19名(19%)的执业医师填写了问卷,19名(19%)的执业医师填写了问卷。包皮环切手术在妇幼医院(32.3%)、三级医院(32.3%)、私立医院(16%)和综合医院或学术医院(19%)进行。Gomco钳是包皮环切术中最常用的方法(n = 39;39.6%),其次是Plastibell (n = 30;30%)和骨切割器(n = 25;25.4%)。包皮环切术的最佳时机为新生儿期。86%的外科医生认为2.5到5公斤是婴儿做包皮环切手术的最佳体重。在沙特阿拉伯,包皮环切是每个穆斯林男性都要做的宗教仪式。应由训练有素的医生进行,应避免由非医务人员进行包皮环切。包皮环切术应在新生儿期进行,并应注意镇痛。
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引用次数: 0
Enhancement of Liver Toxicity on Diabetes Mellitus by a Universal Chemical Pollutant (Acrylonitrile) in Rats 通用化学污染物丙烯腈对糖尿病大鼠肝毒性的增强作用
Pub Date : 2019-12-31 DOI: 10.4197/med.26-2.2
Sameer E. Alharthi
The present study was designed to investigate potential liver damage due to acrylonitrile in Streptozotocin induced diabetes in rats. Twenty-four rats were divided into 4 treatment groups. Nondiabetic control rat receiving distilled water, non-diabetic rat receiving acrylonitrile aqueous solution (10 mg/kg/day), diabetic control rat receiving distilled water and diabetic rat receiving acrylonitrile aqueous solution. All groups received the treatment for 4 weeks. The animals were assessed for hepatoxicity markers in serum, oxidative stress markers, CYP2E1 activity and cyanide formation in tissues. Acrylonitrile significantly elevated serum aminotransferase, alanine aminotransferase, total bilirubin levels, triglycerides and total cholesterol in diabetic groups as compared to normal control group. Antioxidant markers like glutathione showed significant decline while a significant increase in malondialdehyde, superoxide dismutase and catalase in diabetic rats treated with acrylonitrile. CYP2E1 activity was observed in acrylonitrile – exposed nondiabetic and diabetic groups as compared to control. Cyanide formation was raised in both the nondiabetic and diabetic groups as compared to control group. Acrylonitriles can produce acute hepatic injury, induction of diabetes mellitus type II, and accomplish the CYP2E1 enzyme which sequentially leads to generation of oxidative stress and its metabolic product–cyanide that may potentiate the oxidative stress posing more deleterious effect.
本研究旨在探讨丙烯腈对链脲佐菌素诱导的糖尿病大鼠的潜在肝损害。24只大鼠分为4个治疗组。非糖尿病对照组大鼠接受蒸馏水,非糖尿病大鼠接受丙烯腈水溶液(10 mg/kg/天),糖尿病对照组大鼠接受蒸馏水,糖尿病大鼠接受丙烯腈水溶液。各组均治疗4周。测定小鼠血清中肝毒性标志物、氧化应激标志物、组织中CYP2E1活性和氰化物形成。与正常对照组相比,丙烯腈显著提高糖尿病组血清转氨酶、丙氨酸转氨酶、总胆红素水平、甘油三酯和总胆固醇。抗氧化指标如谷胱甘肽显著下降,丙二醛、超氧化物歧化酶和过氧化氢酶显著升高。与对照组相比,观察了暴露于丙烯腈的非糖尿病组和糖尿病组的CYP2E1活性。与对照组相比,非糖尿病组和糖尿病组的氰化物形成都有所增加。丙烯腈可引起急性肝损伤,诱导II型糖尿病,并完成CYP2E1酶的作用,从而导致氧化应激的产生,其代谢产物氰化物可加重氧化应激,造成更大的危害。
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引用次数: 0
Characterizing Occupational Low Back Pain among Surgeons Working in Ministry of Health Hospitals: Prevalence, Clinical Features and Risk and Protective Factors 在卫生部医院工作的外科医生职业性腰痛的特征:患病率、临床特征、风险和保护因素
Pub Date : 2019-12-31 DOI: 10.4197/med.26-2.3
Khaled S. Aseri, A. A. Mulla, R. Alwaraq, R. J. Bahannan
A cross-sectional study was conducted to investigate the prevalence as well as the determinants and clinical features of occupational low back pain among surgeons working at Ministry of Health hospitals in Jeddah, Saudi Arabia by exploring its history combined with time of onset after starting the operating room work and self-appraisal of the relationship with the surgical work. Factors and predictors such as professional, socio-demographic and lifestyle factors, medical history, etc. were collected and analyzed. Two hundred and sixteen surgeons (69.9% males, mean age 39.03 years, median work: 5.00 years) responded. Prevalence of occupational low back pain was 55.8% (95% CI: 49.0%, 62.3%); high rates of inadequate management and self-treatment had a notable impact on all 4 domains. Multivariate regression showed two independent protective factors (regular physical exercise [OR = 0.27, P = 0.002] and back health education [OR = 0.41, P = 0.031] and two independent risk factors (high exposure to risky activities [OR = 1.06, P = 0.048] and presence of chronic pain other than back pain [OR = 2.59, P = 0.012]). More than one in two surgeons are likely to suffer from occupational low back pain. The protective roles of regular physical activity and back health education are highlighted
本研究旨在调查沙特阿拉伯吉达卫生部医院外科医生职业性腰痛的患病率、决定因素和临床特征,探讨其病史、开始手术室工作后发病时间以及与手术工作关系的自我评价。收集并分析职业、社会人口、生活方式、病史等因素及预测因素。216名外科医生回应,其中男性69.9%,平均年龄39.03岁,中位工作时间5.00年。职业性腰痛患病率为55.8% (95% CI: 49.0%, 62.3%);管理和自我治疗不足的高发率对所有4个领域都有显著影响。多因素回归显示两个独立的保护因素(定期体育锻炼[OR = 0.27, P = 0.002]和背部健康教育[OR = 0.41, P = 0.031])和两个独立的危险因素(高危险活动暴露[OR = 1.06, P = 0.048]和存在非背部疼痛的慢性疼痛[OR = 2.59, P = 0.012])。超过二分之一的外科医生可能患有职业性腰痛。强调了定期体育锻炼和背部健康教育的保护作用
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引用次数: 1
Portal Vein Aneurysm Complicated by Thrombosis 门静脉动脉瘤并发血栓形成
Pub Date : 2019-12-31 DOI: 10.4197/med.26-2.8
Doaa Faleh, Seraj Nadir Baeshin, Ghaida Alzahrani, Hesham Tariq Nahhas, Nouri Abbas Abbas
The current study described a case of portal vein aneurysm at the confluence of the superior mesenteric and splenic veins, complicated by thrombosis in a patient with no liver pathology but with Factor V Leiden mutation.
本研究报告1例门静脉动脉瘤位于肠系膜上静脉和脾静脉汇合处,合并血栓形成,患者无肝脏病变,但有因子V Leiden突变。
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引用次数: 0
Effect of Pharmacists’ Interventions on the Appropriateness of Empiric Vancomycin Therapy in Oncology Patients with Febrile Neutropenia 药师干预对肿瘤发热性中性粒细胞减少患者经验性万古霉素治疗适宜性的影响
Pub Date : 2019-12-31 DOI: 10.4197/med.26-2.6
Nour Baghdady, D. Voit, Anne M. McDonell, D. Kubiak
The purpose of this observational study is to evaluate the effect of an active pharmacy intervention to facilitate timely discontinuation of empiric vancomycin therapy in oncology patients with febrile neutropenia who lack objective evidence of a Gram-positive infection. This was a two-phase study. Vancomycin use was evaluated retrospectively on all oncology patients with febrile neutropenia over four weeks (phase I). In a parallel four weeks a year later, vancomycin use in this patient population was evaluated prospectively (phase II). In the absence of evidence of Gram-positive infection after 72 hours of treatment initiation, the team was contacted by a pharmacist to encourage discontinuation. Usage was compared between both phases. Forty-three patients in phase I and 25 patients in phase II were treated with vancomycin with no evidence for Gram-positive infections. Pharmacists’ interventions were documented on 18 patients in phase II. Of these, 56% of interventions to discontinue vancomycin were accepted, but only 33.3% of patients had treatment stopped within 72 hours of initiation. Although not significant, a trend in more appropriate use of vancomycin in oncology patients with febrile neutropenia was observed. Pharmacist’s interventions might have played a role in this observation.
本观察性研究的目的是评估积极的药学干预对缺乏革兰氏阳性感染客观证据的发热性中性粒细胞减少的肿瘤患者及时停止经年性万古霉素治疗的效果。这是一个两阶段的研究。对所有发热性中性粒细胞减少的肿瘤患者在4周内的万古霉素使用情况进行回顾性评估(I期)。在一年后的4周内,对该患者群体的万古霉素使用情况进行前瞻性评估(II期)。在开始治疗72小时后没有革兰氏阳性感染的证据,药剂师联系了该团队,鼓励他们停止治疗。比较了两个阶段的使用情况。43名I期患者和25名II期患者接受万古霉素治疗,没有革兰氏阳性感染的证据。对18例II期患者的药师干预进行了记录。其中,56%的停止万古霉素的干预措施被接受,但只有33.3%的患者在开始治疗的72小时内停止治疗。虽然不显着,但观察到万古霉素在发热性中性粒细胞减少的肿瘤患者中更适当使用的趋势。药剂师的干预可能在这一观察中发挥了作用。
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引用次数: 0
Evaluating Saudi Nursing Students’ Knowledge and Attitudes toward Cancer Pain Management: Implications for Nursing Education 评估沙特护生对癌症疼痛管理的知识和态度:对护理教育的启示
Pub Date : 2019-12-31 DOI: 10.4197/med.26-2.7
D. Wazqar
Ineffective pain management has been recognized as a major problem faced by many patients with cancer. There is a lack of emphasis on cancer pain management in the undergraduate nursing curriculum which is one part of this problem. A descriptive cross-sectional study was carried out with a convenience sample of 135 nursing students at two universities in Jeddah, Saudi Arabia, to evaluate students’ current knowledge and attitudes toward cancer pain management. Data were collected using Pain Management Principles Assessment Test and Nurses’ Pain Management Attitudes Survey. The data were analyzed using IBM Statistical Package for the Social Sciences version 22, and P < 0.05 was interpreted as significant. Descriptive and inferential statistics and Pearson correlations were performed. Nursing students have insufficient knowledge (11.4 ± 2.92) and negative attitudes (68.8 ± 5.75) toward cancer pain management. None of the nursing students achieved complete, correct responses (31 or 100%) in the knowledge test. Students had poor knowledge regarding areas of pain physiology and assessment, pharmacologic and nonpharmacologic pain management such as cutaneous stimulation. A weak positive significant relationship between students’ knowledge and attitudes was also found (r = 0.225, P = 0.009). Continued work is required to develop specific strategies to effectively teach nursing students and enhance their knowledge and attitudes toward cancer pain management.
无效的疼痛管理已被认为是许多癌症患者面临的主要问题。在本科护理课程中缺乏对癌症疼痛管理的重视,这是这个问题的一部分。本研究以沙特阿拉伯吉达两所大学的135名护理专业学生为样本,进行了一项描述性横断面研究,以评估学生目前对癌症疼痛管理的知识和态度。数据收集采用疼痛管理原则评估测试和护士疼痛管理态度调查。使用IBM Statistical Package for Social Sciences version 22对数据进行分析,P < 0.05解释为显著性。进行描述性统计、推理统计和Pearson相关性分析。护生对癌性疼痛管理认知不足(11.4±2.92),态度消极(68.8±5.75)。护生在知识测试中没有一个获得完整、正确的回答(31%或100%)。学生在疼痛生理学和评估、药物和非药物疼痛管理(如皮肤刺激)方面的知识贫乏。学生的知识与态度之间也存在微弱的正相关(r = 0.225, P = 0.009)。需要继续开展工作,制定具体的策略,有效地教育护理学生,提高他们对癌症疼痛管理的知识和态度。
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引用次数: 2
Practices of Jeddah Residents Regarding the Disposal of Unused and Expired Medications: A Community-Based Survey 吉达居民处理未使用和过期药物的做法:一项基于社区的调查
Pub Date : 2019-12-31 DOI: 10.4197/med.26-2.4
Afnan A. Abuassonon, B. Kalkatawi, L. S. Alzahrani, B. Eid, Thikryat A. Neamatallah
Inappropriate disposal of stored medications leads to an increased risk of environmental toxicity. This study aims to examine practices of Jeddah residents with regard to disposing unused and/or expired medications and to view their opinions about the presence of drug take-back centres. Over a three-month period, 771 participants completed an online questionnaire, that focused on disposal methods and the importance of having drug retrieval centres. The data demonstrated that 91.57% of the participants reported discarding their expired medications in household waste, and 2.98% of them return their medications to hospitals or pharmacies. With respect to unused medications, 67.07% of the participants disposed of them in household waste, and only 10.84% donated their medications. This improper practice, however, contradicted the fact that 92.35% of the respondents were interested in knowing the appropriate methods of disposing. In addition, 90.66% agreed to the need for drug take-back centres. This study demonstrated that a low percentage of respondents knew about correct medication disposal. This emphasizes the need for the Ministry of Health, the pharmaceutical industry and pharmacies to collaborate on a national program about the proper methods of medication disposal and to initiate drug retrieval programs.
贮存药物处置不当会增加环境毒性风险。本研究旨在审查吉达居民处理未使用和/或过期药物的做法,并了解他们对药物回收中心存在的意见。在三个月的时间里,771名参与者完成了一份在线问卷,问卷的重点是处理方法和建立药物检索中心的重要性。数据显示,91.57%的参与者报告将过期药品丢弃在生活垃圾中,2.98%的参与者将药品退回医院或药店。对于未使用的药物,67.07%的参与者将其作为生活垃圾处理,只有10.84%的参与者将其捐赠。然而,这种不正当的做法与92.35%的受访者有兴趣了解适当的处理方法的事实相矛盾。此外,90.66%的人同意有必要设立药物回收中心。这项研究表明,一个低百分比的受访者知道正确的药物处置。这就强调了卫生部、制药业和药店必须就药物处置的适当方法开展合作,并启动药物回收方案。
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引用次数: 4
Wait or Intervene: Dentigerous Cyst Associated with Permanent Mandibular Canine 等待还是干预:与永久性下颌犬相关的牙性囊肿
Pub Date : 2018-04-01 DOI: 10.4197/med.25-1.5
Amani A. Al Tuwirqi, Nabil Khzam
Citation Al Tuwirqi AA, Khzam NO. Wait or intervene: dentigerous cyst associated with permanent Mandibular Canine. JKAU Med Sci 2018; 25 (1): 31-38. DOI: 10.4197/Med. 25.1.5 Abstract Dentigerous cysts are developmental odontogenic jaw cysts. Dentigerous cysts require early detection and prompt treatment ranging from marsupialization to complete enucleation. Few of these cysts have been reported in children younger than 12 years of age. The purpose of this case report was to describe the case of an 11-yearold boy with a dentigerous cyst associated with unerupted right mandibular canine. The clinical, radiographic and histopathologic features are discussed. This case report also describes the diagnosis of a mandibular dentigerous cyst using cone beam computed tomography, successful use of conservative enucleation and explains the need for such a radical treatment approach.
引证Al Tuwirqi AA, Khzam NO。等待或干预:与永久性下颌犬齿相关的含牙囊肿。中华医学会医学杂志2018;25(1): 31-38。DOI: 10.4197 /地中海。齿性囊肿是发育性牙源性颌骨囊肿。含牙囊肿需要早期发现和及时治疗,从有袋切除到完全去核。在12岁以下的儿童中很少有这些囊肿的报道。本病例报告的目的是描述一个11岁的男孩与一个含牙囊肿与未爆发的右下颌骨。讨论了临床、影像学和组织病理学特征。本病例报告还描述了使用锥形束计算机断层扫描诊断下颌含牙囊肿,成功地使用保守去核,并解释了这种根治性治疗方法的必要性。
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引用次数: 0
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Journal of King Abdulaziz University-medical Sciences
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