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Essential Oil and Quinolizidine Alkaloids of Retama Raetam (Forssk) Webb & Berthel (Fabaceae) Grown in Jordan 在约旦生长的reama Raetam (Forssk) Webb & Berthel (Fabaceae)的精油和喹诺嗪类生物碱
Pub Date : 1900-01-01 DOI: 10.23880/ipcm-16000196
Suleiman M. Olimat
Retama raetam essential oils (EOs) and quinolizidine alkaloids (QA) composition were studied. A quantitative analysis using a GC-MS analysis of the flowers revealed the presence of monoterpenes (47.62%), monoterpene hydrocarbons (28.6%) and oxygenated monoterpenes (14.3%) and sesquiterpenes (47.6%), exclusively sesquiterpenes hydrocarbon. The principal oil component was 49% mesitylene. The young twigs of R. reatam revealed the presence of quinolizidine alkaloids (QA). The alkaloids identified were 5,6-dehydrolupanine, β-isolupanine, 17-oxolupanine, anagyrine, β-isospartine, and spartine; 17-oxolupanine was the major alkaloid in the twigs.
研究了雷达姆精油(EOs)和喹诺嗪类生物碱(QA)的组成。采用气相色谱-质谱法对其进行了定量分析,发现其主要成分为单萜烯(47.62%)、单萜烯烃(28.6%)、氧合单萜烯(14.3%)和倍半萜烯(47.6%)。主要油组分为49%的三聚氰胺。芦笋幼枝中含有喹啉类生物碱(QA)。鉴定出的生物碱有5,6-脱氢羽扇豆氨酸、β-异亮氨酸、17-氧亮氨酸、苦楝碱、β-异斯米氨酸和斯米氨酸;细枝中主要的生物碱为17-氧酰丙氨酸。
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引用次数: 0
Preliminary Phytochemical and Pharmacognostic Studies on a Well-known Medicinal Plant Glycyrrhiza glabra 知名药用植物甘草的植物化学和生药学初步研究
Pub Date : 1900-01-01 DOI: 10.23880/ipcm-16000191
Vijay Danapur
Glycyrrhiza glabra is a perennial herb in the subtropical and warm temperate regions. The principal constituent of licorice is glycyrrhizin. Licorice is used for the treatment of asthma, acute and chronic bronchitis and chronic cough. It modulates the immune system and has remarkable immuno-stimulant properties. The phyto-constituents like glycyrrhizin and glycyrrhizinic acid, triterpenoid glycosides (saponins), flavonoids (including liquiritigetol) are potent components for health benefits. It is a mild anti-inflammatory for arthritis and rheumatism and is used to treat gastric, duodenal and esophageal ulceration of inflammation, heartburn and mouth ulcers. Since it has got so many pharmacological activities it is important to standardize this drug, hence the present study.
甘草是亚热带和暖温带地区的多年生草本植物。甘草的主要成分是甘草酸。甘草用于治疗哮喘、急慢性支气管炎和慢性咳嗽。它调节免疫系统,具有显著的免疫刺激特性。植物成分,如甘草酸和甘草酸,三萜苷(皂苷),类黄酮(包括甘草糖醇)是对健康有益的有效成分。它是一种温和的抗炎剂,用于关节炎和风湿病,用于治疗胃,十二指肠和食管溃疡的炎症,胃灼热和口腔溃疡。由于其具有多种药理活性,因此对其进行规范化研究具有重要意义。
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引用次数: 0
Standardization & Safety Measures: Quality-Based Validation of Herbal Medicine 标准化与安全措施:中草药质量验证
Pub Date : 1900-01-01 DOI: 10.23880/ipcm-16000182
S. Jain
Herbal medicines magnetize the curiosity of both patients and scientists, in all aspects of drug development from natural products and also for rationale of traditional medicine (TM). Numerous developing countries rely on TM because of their convenience and affordability, and scientists all over the world believe medicinal plants as a resource of new chemical entities and use them to isolate compounds such as Sennoside, quinine, strychnine, digoxin, morphine, taxol, atropine, and vinblastine
草药吸引了病人和科学家的好奇心,从天然产物到药物开发的各个方面,以及传统医学(TM)的基本原理。许多发展中国家依赖传统植物,因为它们方便且价格低廉,世界各地的科学家都认为药用植物是一种新的化学实体资源,并利用它们分离出Sennoside、奎宁、士的宁、地高辛、吗啡、紫杉醇、阿托品和长春花碱等化合物
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引用次数: 2
Aromatic Profiles and Antimicrobial Activities of Two Ocimum basilicum Varieties 两个罗勒品种的芳香谱及抑菌活性研究
Pub Date : 1900-01-01 DOI: 10.23880/ipcm-16000183
O. Eldahshan
The volatile oils isolated from both Ocimum basilicum var. purpurascens and Ocimum basilicum var. basilicum, in Yemen, were analyzed by GC/FID and GC/MS. Twenty peaks were detected (100%) in Ocimum basilicum var. basilicum oil where l-Linalool was the highest one (39.0%) followed by cis-anethole (20.0%), guaiol (8.9%) and 1,8-cineole (7.2%). Ocimum basilicum var. purpurascens chromatogram revealed the presence of twenty peaks which represented 100% of the total peaks. l-Linalool (41.8%), α-copaene (22.3%) and 1,8-cineole (10.6%) were the most representative components. Ocimum basilicum var. basilicum, was more effective as antimicrobial agent than Ocimum basilicum var. purpurascens where it showed potent activity against Bacillis subtilis (MIC is 3.90 μL/mL) and moderate activities against both Staphylococcus aureus and Escherichia coli (MIC value for both 7.8 μL/Ml). Ocimum basilicum var. basilicum induced potent antifungal activities against Saccharomyces cerevisiae (MIC 3.90 μL/mL).
采用气相色谱- FID和气相色谱-质谱联用技术对也门产紫荆罗勒和罗勒的挥发油进行了分析。罗勒油中共检出20个峰(100%),其中l-芳樟醇含量最高(39.0%),其次为顺式茴香脑(20.0%)、愈创木酚(8.9%)和1,8-桉叶脑(7.2%)。紫癜性罗勒色谱图显示有20个峰,占总峰的100%。l-芳樟醇(41.8%)、α-copaene(22.3%)和1,8-桉叶脑(10.6%)是最具代表性的成分。对枯草芽孢杆菌的抑菌活性为3.90 μL/mL,对金黄色葡萄球菌和大肠杆菌的抑菌活性均为7.8 μL/mL,对紫癜性紫癜的抑菌活性较好。basilicum var. basilicum对酿酒酵母(Saccharomyces cerevisiae)具有较强的抑菌活性(MIC为3.90 μL/mL)。
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引用次数: 0
The Prevailing Overview of Inorganic Content of Plants 植物无机含量的流行概况
Pub Date : 1900-01-01 DOI: 10.23880/ipcm-16000173
S. Wahab
Plants have perpetually remained a beginning of inspiration and vogue of livelihood to humankind since ages. Plant stemmed plus other natural product contributed countless novel bioactive molecules that are available in the market today as medicines or food. Wild edible plants are considered as one of the cheapest sources of energy for human consumption
自古以来,植物一直是人类灵感的源泉和生活的时尚。植物茎和其他天然产物贡献了无数新的生物活性分子,这些分子在今天的市场上作为药物或食品可用。野生可食用植物被认为是人类消费的最便宜的能源之一
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引用次数: 0
Taxonomic Study on the Wild Species of Genus Solanum L in the Southern Western Ghats of Tamil Nadu 标题泰米尔纳德邦西部高止山脉南部野生种茄属植物的分类研究
Pub Date : 1900-01-01 DOI: 10.23880/ipcm-16000187
S. K
An excursion flora of Solanum (Solanaceae), distributed in Southern Western Ghats ecoregions of Tamil Nadu. The work illustrated to study of complete morphological features of each species, distribution, nomenclature, synonyms, vernacular name, common name, flowering season, Geographical locations, Ecological status, GPS co-ordinate, elevation, habitat, enthnomedicinal uses, formulations and the taxonomic relationships between the studied species is represented by the cluster analysis. The Morphological characters indicated highly significant role in the identification of the species. Based on the detailed survey, two species was native species and remaining three species were invasive plants. The morphological variations measured by Eluidean distance process and phonogram were constructed. The phenogram showed that the studied species of genus Solanum can simply be divided into two groups that are Melongena and Solanum. The phylogram was represented by using parsimony analysis of the morphological data. The phylogram showed that most of the species are distributed all over the study area. Therefore the goal of the present study was to identify distinctive morphological feature on both of Phylogram, and Phenogram. The results was represented showed great similarity between S.virgianianum and S. incanum suggesting that the two species can be considered as one species with two subspecies or varieties.
龙葵属(龙葵科)的一种短途植物群,分布于泰米尔纳德邦西部高止山脉的南部生态区。通过聚类分析来研究每个物种的完整形态特征、分布、命名、近义词、方言名、常用名、开花季节、地理位置、生态状况、GPS坐标、海拔、生境、民族医药用途、配方以及所研究物种之间的分类关系。其形态特征对物种鉴别具有重要意义。经详细调查,2种为本地种,其余3种为入侵植物。构造了以易留德距离法和声像图法测量的形态变异。物象图表明,所研究的龙葵属植物可简单地分为龙葵属和龙葵属两类。利用形态学数据的简约性分析来表示系统谱。系统分布图显示,大部分物种分布在研究区内。因此,本研究的目的是在系统图和物候图上确定不同的形态特征。结果表明,维吉尼亚和金菖蒲具有很高的相似性,这表明这两个物种可以看作是一个物种,有两个亚种或变种。
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引用次数: 4
Topical Preparation and Antimicrobial Study of Crude Extracts of Syzygium cumini (L) Skeel Leaves 茴香叶粗提物的局部制备及抗菌研究
Pub Date : 1900-01-01 DOI: 10.23880/ipcm-16000148
A. D.
The aim of the study is antimicrobial study of crude extracts of S. cumini leaves and further topical preparation from Methanolic extract. For this successive soxhlet extracted petroleum ether, diethyl ether, methanol and aqueous extracts of leaves of S. cumini were subjected to antimicrobial activity test (antibacterial and anti-fungal test). Antimicrobial activity testing was done by agar well diffusion method. The organism tested were gram positive organism: Staphylococcus aureus (ATCC) and MRSA and gram negative organism: E. coli, Pseudomonas aeruginosa, Klebsellapneumonia for antibacterial and candida albican for antifungal Excellent antimicrobial activity was shown by Methanolic extract in comparison to other extract. From the result of antibacterial test of plant extract further gel and ointment were formulated from Methanolic extract which too showed antibacterial activity comparable to plant extract.
本研究的目的是研究茴香叶粗提物的抑菌作用,并进一步研究甲醇提取物的外用制剂。本实验采用索氏提取油醚、乙醚、甲醇和水提物分别对菟丝子叶片进行抑菌活性试验(抑菌和抗真菌试验)。采用琼脂孔扩散法进行抑菌活性测定。检测的革兰氏阳性菌为金黄色葡萄球菌(ATCC)和MRSA,革兰氏阴性菌为大肠杆菌、铜绿假单胞菌、克雷伯氏肺炎和白色念珠菌,与其他提取物相比,甲醇提取物的抑菌活性较好。根据植物提取物的抑菌试验结果,进一步研制出了与植物提取物相当的乙醇提取物凝胶和软膏。
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引用次数: 0
Efficiency of Acupuncture and Transcutaneous Electroneurostimulation in Treatment of Patients with Anxiety Disorders 针刺与经皮神经电刺激治疗焦虑症的疗效观察
Pub Date : 1900-01-01 DOI: 10.23880/ipcm-16000214
Al'-Zamil' MKh
Introduction: The effectiveness of transcutaneous electrical nerve stimulation (TENS) in the management of Anxiety disorders (AD) compared with standard pharmacotherapy and acupuncture was demonstrated in rare clinical research studies. Objective: To study the dynamics of anxiety disorders with the use of a direct TENS and acupuncture. Materials and Methods: 59 patients with AD were examined. 12 patients underwent only pharmacotherapy. 12 patients underwent low-frequency high-amplitude TENS (LH TENS) of the right median nerve. 11 patients have been treated by highfrequency low-amplitude (HL TENS) of the right median nerve. 12 patients received a course of LH TENS of the right tibial nerve. 12 patients underwent course of acupuncture. Results: GAD-7 shows that the decrease in the severity of anxiety disorders was most of all after acupuncture and averaged 47.9%, in second place - after LH TENS of the median nerve and averaged 44±3%, in third place - after LH TENS of the tibial nerve and averaged 30.2±5 %, in fourth place after HL TENS of the median nerve (14±6%) and least of all after only use of pharmacotherapy (17.2±5%). There was a significant improvement in the quality of life identified using SF-36 by 37% in patients after acupuncture, by 35% in patients after LH TENS of the median nerve, by 20% in patients after LH TENS of the tibial nerve, by 11% in patients after HL TENS of the median nerve and by 13% after pharmacotherapy. Conclusion: Acupuncture proved to be more effective than LH TENS of the median nerve in treating AD. At the same time, improving the quality of life has the same results in the two methods of treatment. Direct LH TENS is more effective than direct HL TENS in the treatment of patients with anxiety disorders. Stimulation of the median nerve was found to be more effective than stimulation of the tibial nerve by 66% in decreasing anxiety disorders and by 75% in improving quality of life.
引言:经皮神经电刺激(TENS)治疗焦虑症(AD)的有效性在罕见的临床研究中得到了证实,与标准药物治疗和针灸治疗相比。目的:探讨直接电刺激法与针刺治疗对焦虑障碍的影响。材料与方法:对59例AD患者进行检查。12例患者仅接受药物治疗。12例患者行右正中神经低频高幅TENS (LH TENS)。采用高频低幅(HL TENS)法治疗右正中神经损伤11例。12例患者接受右胫神经的LH - TENS治疗。12例患者接受疗程针灸治疗。结果:GAD-7显示,焦虑障碍严重程度的减轻程度以针刺组最多,平均为47.9%,其次为正中神经LH - TENS,平均为44±3%,第三为胫神经LH - TENS,平均为30.2±5%,第四为正中神经HL - TENS,平均为14±6%,仅使用药物治疗组最小,平均为17.2±5%。针刺后使用SF-36治疗的患者生活质量显著改善37%,正中神经LH - TENS治疗后改善35%,胫骨神经LH - TENS治疗后改善20%,正中神经HL - TENS治疗后改善11%,药物治疗后改善13%。结论:针刺治疗阿尔茨海默病的疗效优于正中神经的LH - TENS。同时,改善生活质量在两种治疗方法中具有相同的效果。直接使用LH - TENS治疗焦虑症患者比直接使用HL - TENS更有效。在减少焦虑症方面,刺激正中神经比刺激胫骨神经更有效66%,在改善生活质量方面,刺激胫骨神经更有效75%。
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引用次数: 0
Natural Product Chemistry and Computer Aided Drug Design an Approach to Drug Discovery: A Review Article 天然产物化学和计算机辅助药物设计——一种药物发现的方法
Pub Date : 1900-01-01 DOI: 10.23880/ipcm-16000207
S. Ugariogu
Natural products have been an inherent part of sustaining acculturation because of their medicinal properties. Past discoveries of bioactive natural products have relied on serendipity and accidental experience, and these compounds serve as inspiration for the generation of analogs with desired physicochemical properties. Bioactive natural products with therapeutic potential are abundantly available in nature and some of them are beyond exploration by conventional methods. However there has been a great breakthrough in the study of computer aided drug design (CADD) as many unfruitful lab researches have been averted and money, time and energies saved through CADD. Computer-aided drug design is a stimulating, arousing and manifold discipline where various aspects of applied and basic research integrate and induce each other. The empirical basis of CADD involves quantum mechanics and molecular modeling studies like structure based drug design; ligand-based drug design; database searching and binding affinity based on the knowledge of a biological target. In this present review we present the areas where natural product chemistry and CADD tools support drug discovery processes.
由于天然产品的药用特性,它们一直是维持文化适应的固有组成部分。过去生物活性天然产物的发现依赖于意外发现和偶然的经验,这些化合物为产生具有所需物理化学性质的类似物提供了灵感。具有治疗潜力的生物活性天然产物在自然界中大量存在,其中一些是传统方法无法探索的。然而,计算机辅助药物设计(CADD)的研究取得了很大的突破,避免了许多徒劳的实验室研究,节省了金钱、时间和精力。计算机辅助药物设计是一门应用研究与基础研究相结合、相互促进的学科。CADD的经验基础包括量子力学和分子模型研究,如基于结构的药物设计;配体药物设计;基于生物靶标知识的数据库搜索和绑定亲和力。在本综述中,我们介绍了天然产物化学和CADD工具支持药物发现过程的领域。
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引用次数: 2
ICD-11 Helps Link East-West Clinical Data for Potential Drug Discovery ICD-11有助于将东西方临床数据联系起来,以发现潜在的药物
Pub Date : 1900-01-01 DOI: 10.23880/ipcm-16000194
H. Koon
With the advancement of computational science and technology, medical records have been transformed from the previous handwritten mode to the electronic format. Precise and systematic storage of patient data including demographics, diagnosis, medication, laboratory test results and radiological reports is possible. Retrospective investigation of the electronic health records (eHR) could probably find novel relationships between diseases reevaluate drug usage and discover phenotype–genotype associations
随着计算科学技术的进步,病历已经从以前的手写模式转变为电子格式。可以精确和系统地存储患者数据,包括人口统计、诊断、药物、实验室检测结果和放射报告。电子健康记录(eHR)的回顾性调查可能会发现疾病之间的新关系,重新评估药物使用和发现表型-基因型关联
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引用次数: 0
期刊
International Journal of Pharmacognosy & Chinese Medicine
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