Pub Date : 2022-02-01DOI: 10.23736/s2784-8477.22.01992-1
Y. Feshchenko, M. Ostrovskyy, O. Varunkiv, Nataliia H. Horovenko
ACKGROUND: Patients discharged from hospital after COVID-19-associated pneumonia often experience persistent symptoms (e.g., dyspnea, cough, fatigue), which affect their quality of life. Treatments are needed to solve these residual effects of COVID-19 and to help patients in making a full recovery. METHODS: We performed a single center open-label study to assess the impact of the oral mucolytic agent erdosteine (300 mg twice daily) for 30 days on 38 patients discharged from hospital after COVID-19-associated pneumonia who had persistent dyspnea. After discharge, all patients stopped taking all treatment for COVID-19 received during their hospital stay but continued their usual treatment for chronic diseases and they were divided into two groups: the treatment group, which received erdosteine 300 mg twice daily for 30 days and the control group, with no treatment. Patients completed St George's Respiratory Questionnaire (SGRQ) and the modified Medical Research Council (mMRC) dyspnea scale at time of discharge (Day 0) and on Day 30. The treatment group (N.=26) was compared with a control group (N.=12). RESULTS: SGRQ and mMRCscores were comparable between the treatment and control groups at hospital discharge. Both scores improved significantly in the treatment group between day 0 and day 30, whereas were not significant changes in the control group. At Day 30, significantly more patients in the treatment group than the control group had achieved clinically important changes in HRQoL and symptoms. CONCLUSIONS: In patients hospitalized for COVID-19-associated pneumonia Erdosteine treatment following hospital discharge may help their recovery, improving dyspnea and HRQoL.
{"title":"Improved quality of life and dyspnea with erdosteine in COVID-19 patients after hospital discharge","authors":"Y. Feshchenko, M. Ostrovskyy, O. Varunkiv, Nataliia H. Horovenko","doi":"10.23736/s2784-8477.22.01992-1","DOIUrl":"https://doi.org/10.23736/s2784-8477.22.01992-1","url":null,"abstract":"ACKGROUND: Patients discharged from hospital after COVID-19-associated pneumonia often experience persistent symptoms (e.g., dyspnea, cough, fatigue), which affect their quality of life. Treatments are needed to solve these residual effects of COVID-19 and to help patients in making a full recovery. METHODS: We performed a single center open-label study to assess the impact of the oral mucolytic agent erdosteine (300 mg twice daily) for 30 days on 38 patients discharged from hospital after COVID-19-associated pneumonia who had persistent dyspnea. After discharge, all patients stopped taking all treatment for COVID-19 received during their hospital stay but continued their usual treatment for chronic diseases and they were divided into two groups: the treatment group, which received erdosteine 300 mg twice daily for 30 days and the control group, with no treatment. Patients completed St George's Respiratory Questionnaire (SGRQ) and the modified Medical Research Council (mMRC) dyspnea scale at time of discharge (Day 0) and on Day 30. The treatment group (N.=26) was compared with a control group (N.=12). RESULTS: SGRQ and mMRCscores were comparable between the treatment and control groups at hospital discharge. Both scores improved significantly in the treatment group between day 0 and day 30, whereas were not significant changes in the control group. At Day 30, significantly more patients in the treatment group than the control group had achieved clinically important changes in HRQoL and symptoms. CONCLUSIONS: In patients hospitalized for COVID-19-associated pneumonia Erdosteine treatment following hospital discharge may help their recovery, improving dyspnea and HRQoL.","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"46 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87564264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.23736/s2784-8477.21.01945-8
Erdi Çiğdem, S. Yazgan, Ahemt Üçvet, G. Batihan
Extralobar pulmonary sequestration is a rare congenital disease of the primitive foregut. This case report describes an adult with asymptomatic extralobar sequestration who was successfully treated with the video-assisted thoracic surgery. We performed a superior segment-preserving lower lobectomy and complete resection of the sequestered mass due to the atypical incomplete fissure. This approach allowed a patient to recover uneventfully to preserve pulmonary function and it provides patient satisfaction by causing less postoperative pain.
{"title":"Videothoracoscopic segmentectomy in extralobar pulmonary sequestration: safe and effective procedure","authors":"Erdi Çiğdem, S. Yazgan, Ahemt Üçvet, G. Batihan","doi":"10.23736/s2784-8477.21.01945-8","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01945-8","url":null,"abstract":"Extralobar pulmonary sequestration is a rare congenital disease of the primitive foregut. This case report describes an adult with asymptomatic extralobar sequestration who was successfully treated with the video-assisted thoracic surgery. We performed a superior segment-preserving lower lobectomy and complete resection of the sequestered mass due to the atypical incomplete fissure. This approach allowed a patient to recover uneventfully to preserve pulmonary function and it provides patient satisfaction by causing less postoperative pain.","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"194 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79744191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.23736/s2784-8477.21.01953-7
P. Solidoro, V. Fanelli, A. Pittaro, L. Delsedime, M. Papotti, F. Patrucco, M. Boffini, M. Mangiapia, C. Albera, L. Brazzi
During the COVID-19 pandemic in Northern Italy, a young man with fever and dyspnea was admitted to the Emergency Department. The sudden development of severe hypoxemia and respiratory acidosis forced the emergency medical team to intubate the patient. Fiberoptic bronchoscopy and chest CT scan showed the presence of a bleeding neoformation, occluding the majority of tracheal lumen requiring the connection to a veno-venous extracorporeal respiratory support. A rigid bronchoscopy was performed to clear the tracheal lumen, obtaining a diagnosis of "composite hemangioendothelioma." All personnel involved was equipped with personal protective equipment (PPE) and power air-purifying respirators (PAPR). ECMO and mechanical ventilation were soon weaned, lung CT showed an almost complete patency of tracheobronchial tree. To the best of our knowledge, this is the first rigid bronchoscopic procedure reported in a SARS-CoV-2 virus pneumonia respiratory failure requiring ECMO, allowing to diagnose an extremely rare endobronchial tumor.
{"title":"First rigid bronchoscopy in COVID-19 pneumonia to treat a rare endobronchial tumor during extracorporeal membrane oxygenation","authors":"P. Solidoro, V. Fanelli, A. Pittaro, L. Delsedime, M. Papotti, F. Patrucco, M. Boffini, M. Mangiapia, C. Albera, L. Brazzi","doi":"10.23736/s2784-8477.21.01953-7","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01953-7","url":null,"abstract":"During the COVID-19 pandemic in Northern Italy, a young man with fever and dyspnea was admitted to the Emergency Department. The sudden development of severe hypoxemia and respiratory acidosis forced the emergency medical team to intubate the patient. Fiberoptic bronchoscopy and chest CT scan showed the presence of a bleeding neoformation, occluding the majority of tracheal lumen requiring the connection to a veno-venous extracorporeal respiratory support. A rigid bronchoscopy was performed to clear the tracheal lumen, obtaining a diagnosis of \"composite hemangioendothelioma.\" All personnel involved was equipped with personal protective equipment (PPE) and power air-purifying respirators (PAPR). ECMO and mechanical ventilation were soon weaned, lung CT showed an almost complete patency of tracheobronchial tree. To the best of our knowledge, this is the first rigid bronchoscopic procedure reported in a SARS-CoV-2 virus pneumonia respiratory failure requiring ECMO, allowing to diagnose an extremely rare endobronchial tumor.","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"34 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74493854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.23736/s2784-8477.21.01905-2
U. Can, Ş. Yosunkaya, F. Yerlikaya, S. Demirbaş
{"title":"Tumor necrosis factor-α, decoy receptor-3, ficolin-2, presepsin and heat shock protein 70 in pleural effusions","authors":"U. Can, Ş. Yosunkaya, F. Yerlikaya, S. Demirbaş","doi":"10.23736/s2784-8477.21.01905-2","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01905-2","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"83 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79344599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.23736/s2784-8477.21.01952-5
M. Mondoni, P. Carlucci, R. Rinaldo, G. Cipolla, N. Vanoni, A. Fois, P. Pirina, S. Gasparini, M. Bonifazi, S. Marani, A. Comel, L. Saderi, Beatrice Vigo, F. Alfano, P. Solidoro, S. Centanni, G. Sotgiu
{"title":"Clinical features and long-term prognostic outcomes in patients with hemoptysis related to upper respiratory airways diseases: a prospective, Italian, multicenter study","authors":"M. Mondoni, P. Carlucci, R. Rinaldo, G. Cipolla, N. Vanoni, A. Fois, P. Pirina, S. Gasparini, M. Bonifazi, S. Marani, A. Comel, L. Saderi, Beatrice Vigo, F. Alfano, P. Solidoro, S. Centanni, G. Sotgiu","doi":"10.23736/s2784-8477.21.01952-5","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01952-5","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"46 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86584181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.23736/s2784-8477.21.01985-9
F. Patrucco, C. Albera, E. Clivati, M. Boffini, M. Rinaldi, C. Costa, R. Cavallo, P. Solidoro
BacKGroUNd: there are few validated scores evaluating outcomes of lung transplanted patients based on donor or recipient characteristic before or at the time of transplantation. MetHods: in our study we evaluated a new, and easy to use, 5-item score on survival of patients who underwent lung transplantation. It was called SELeCT Score and was based on clinical, laboratoristic and radiological findings recorded at each observation. resULts: We found higher scores in case of unscheduled observations and an inverse correlation with overall survival rate, even excluding patients who died within 60 days. We identified a threshold of 2 points as significant to predict patients’ survival. Fungal and bacterial infections show scores higher than acute rejections and cMV and other viral infections. coNcLUsioNs: seLect score could represent a useful prognostic tool in guiding clinical choices, demonstrating that more compromised patients (routinely evaluated with clinic, laboratory test and radiological images) had a worse outcome, and that it could be important at least as much as
{"title":"Analysis of survival in lung transplantation: simple diagnostic tests in a new \"SELeCT\" Score used as prognostic tool. Results from a single center cohort study","authors":"F. Patrucco, C. Albera, E. Clivati, M. Boffini, M. Rinaldi, C. Costa, R. Cavallo, P. Solidoro","doi":"10.23736/s2784-8477.21.01985-9","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01985-9","url":null,"abstract":"BacKGroUNd: there are few validated scores evaluating outcomes of lung transplanted patients based on donor or recipient characteristic before or at the time of transplantation. MetHods: in our study we evaluated a new, and easy to use, 5-item score on survival of patients who underwent lung transplantation. It was called SELeCT Score and was based on clinical, laboratoristic and radiological findings recorded at each observation. resULts: We found higher scores in case of unscheduled observations and an inverse correlation with overall survival rate, even excluding patients who died within 60 days. We identified a threshold of 2 points as significant to predict patients’ survival. Fungal and bacterial infections show scores higher than acute rejections and cMV and other viral infections. coNcLUsioNs: seLect score could represent a useful prognostic tool in guiding clinical choices, demonstrating that more compromised patients (routinely evaluated with clinic, laboratory test and radiological images) had a worse outcome, and that it could be important at least as much as","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86541956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.23736/s2784-8477.21.01949-5
F. Bardaro, E. Stirpe
{"title":"Late-onset pneumothorax as a complication of COVID-19 disease","authors":"F. Bardaro, E. Stirpe","doi":"10.23736/s2784-8477.21.01949-5","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01949-5","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"31 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87211611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.23736/s2784-8477.21.01921-0
Zeinab Mohseni Afshar, A. Babazadeh, A. Janbakhsh, M. Afsharian, S. Ebrahimpour
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a global emergency by the World Health Organization (WHO). Several ways have been used to control and manage the COVID-19 pandemic. Among them, development of vaccines could be an important breakthrough against novel virus. It is important to note that the candidate vaccine is expected to work against infection and transmission. To date, many COVID-19 vaccine clinical trials have been registered worldwide. However, some vaccine candidates could meet adequate standards for effectiveness and safety. In the current review, we discussed the effectiveness, safety, target population, and hesitancy of COVID-19 vaccines.
{"title":"COVID-19 vaccines: challenges and solutions","authors":"Zeinab Mohseni Afshar, A. Babazadeh, A. Janbakhsh, M. Afsharian, S. Ebrahimpour","doi":"10.23736/s2784-8477.21.01921-0","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01921-0","url":null,"abstract":"Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a global emergency by the World Health Organization (WHO). Several ways have been used to control and manage the COVID-19 pandemic. Among them, development of vaccines could be an important breakthrough against novel virus. It is important to note that the candidate vaccine is expected to work against infection and transmission. To date, many COVID-19 vaccine clinical trials have been registered worldwide. However, some vaccine candidates could meet adequate standards for effectiveness and safety. In the current review, we discussed the effectiveness, safety, target population, and hesitancy of COVID-19 vaccines.","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"6 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79128606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.23736/s2784-8477.21.01917-9
Olga Kastritsi, Stelios Sakellaris, G. Petra, I. Drositis, Emmanouela Mavridi, G. Sakellaris
{"title":"Necrotizing pneumonia: an incipient problem in children, report of two cases","authors":"Olga Kastritsi, Stelios Sakellaris, G. Petra, I. Drositis, Emmanouela Mavridi, G. Sakellaris","doi":"10.23736/s2784-8477.21.01917-9","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01917-9","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"4 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75250453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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