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Advancement of Nanomaterials- and Biomaterials-Based Technologies for Wound Healing and Tissue Regenerative Applications. 推进基于纳米材料和生物材料的伤口愈合和组织再生应用技术。
IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-03-17 Epub Date: 2025-02-28 DOI: 10.1021/acsabm.5c00075
Durba Banerjee, Kalyan Vydiam, Venugopal Vangala, Sudip Mukherjee

Patients and healthcare systems face significant social and financial challenges due to the increasing number of individuals with chronic external and internal wounds that fail to heal. The complexity of the healing process remains a serious health concern, despite the effectiveness of conventional wound dressings in promoting healing. Recent advancements in materials science and fabrication techniques have led to the development of innovative dressings that enhance wound healing. To further expedite the healing process, novel approaches such as nanoparticles, 3D-printed wound dressings, and biomolecule-infused dressings have emerged, along with cell-based methods. Additionally, gene therapy technologies are being harnessed to generate stem cell derivatives that are more functional, selective, and responsive than their natural counterparts. This review highlights the significant potential of biomaterials, nanoparticles, 3D bioprinting, and gene- and cell-based therapies in wound healing. However, it also underscores the necessity for further research to address the existing challenges and integrate these strategies into standard clinical practice.

由于越来越多的人患有无法愈合的慢性外部和内部伤口,患者和医疗保健系统面临着巨大的社会和经济挑战。尽管传统伤口敷料能有效促进伤口愈合,但愈合过程的复杂性仍然是一个严重的健康问题。近年来,材料科学和制造技术的进步促使人们开发出了能促进伤口愈合的创新型敷料。为了进一步加快伤口愈合,出现了纳米粒子、3D 打印伤口敷料、生物分子注入敷料等新方法,以及基于细胞的方法。此外,基因治疗技术也被用来生成干细胞衍生物,这些衍生物比天然干细胞更具功能性、选择性和反应性。本综述强调了生物材料、纳米颗粒、三维生物打印以及基因和细胞疗法在伤口愈合方面的巨大潜力。不过,它也强调了进一步研究的必要性,以解决现有的挑战,并将这些策略纳入标准临床实践。
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引用次数: 0
Preparation of Metal-Polyphenol Modified Zeolitic Imidazolate Framework-8 Nanoparticles for Cancer Drug Delivery. 制备用于癌症药物传输的金属-多酚修饰唑基咪唑啉框架-8 纳米粒子
IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-03-17 Epub Date: 2025-02-14 DOI: 10.1021/acsabm.4c01608
Giao Thuy-Quynh Vu, Luan Minh Nguyen, Kim Ngan Nguyen Do, Dieu Linh Tran, Toi Van Vo, Dai Hai Nguyen, Long Binh Vong

With the rising incidence of cancer, chemotherapy has become a widely used treatment approach. However, the use of anticancer drugs such as doxorubicin (DOX) poses significant long-term risks due to its nonspecific distribution and severe side effects. Therefore, developing a nanoparticle-based drug delivery system (DDS) that enhances the bioavailability of DOX specifically to cancer cells is crucial while minimizing its side effects on normal cells. This study employed zeolitic imidazolate framework-8 (ZIF-8) as a DDS to encapsulate DOX using a one-pot method. The surface of this system was subsequently modified with a copper-gallic acid (Cu-GA) complex to form the Cu-GA/DOX@ZIF-8 (CGDZ) system. The CGDZ system effectively encapsulates DOX and demonstrates pH-responsive drug release, facilitating controlled drug release in the acidic environment of cancer cells. Furthermore, the Cu-GA coating enhances the biocompatibility of the material, reduces drug toxicity in normal endothelial cells (BAECs) due to the antioxidant feature of modified GA, and maintains the efficacy and intracellular trafficking of DOX in colon cancer cells (C-26). Interestingly, CGDZ nanoparticles showed significantly higher toxicity against cancer cells as compared to unmodified systems and free DOX. Overall, CGDZ exhibited significant in vitro efficacy in targeting cancer cell lines while reducing the toxicity of DOX, offering a novel and effective nanoparticle system for targeted cancer treatment.

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引用次数: 0
Biomimetic Molecularly Imprinted Nanogels for the Recognition of Spike Glycoproteins.
IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-03-17 Epub Date: 2025-02-17 DOI: 10.1021/acsabm.4c01757
Iulia Elena Neblea, Tanţa-Verona Iordache, Andrei Sarbu, Anita-Laura Chiriac, Ana-Mihaela Gavrila, Bogdan Trica, Iuliana Elena Biru, Iuliana Caras, Mircea Teodorescu, François-Xavier Perrin, Anamaria Zaharia

The rapid spread and mutation of SARS-CoV-2, the virus responsible for COVID-19, has set the foundation for extensive research into next-generation therapeutic strategies. A critical component of SARS-CoV-2 is the trimeric Spike (S) glycoprotein, which facilitates viral entry into host cells by interacting with the receptor-binding domain (RBD). To inhibit and block viral entry, we designed and developed molecularly imprinted synthetic nanogel antibodies (MIP-SNAs) that cap the Spike S1 RBD. This aims to provide a versatile, biosecure, and effective therapeutic tool for the prevention and treatment of SARS-CoV-2 infection. Herein, we employed reverse miniemulsion polymerization to synthesize MIP-SNAs using poly(ethylene glycol) diacrylate (PEGDA), a nontoxic, nonimmunogenic and FDA-approved polymer, able to interact noncovalently with the functional groups of template Spike S1 RBD. In addition, the formulation of MIP-SNAs was based on a preliminary investigation of protein conformation by circular dichroism. Characterization of the SNAs was conducted using several techniques to investigate the chemical structure, thermal stability, size, and morphology. Under optimal conditions, the MIP-SNAs exhibited high specificity, with rebinding capacities up to 6-fold higher compared to the control nonimprinted synthetic nanogel antibodies. MIP-SNAs also demonstrated notable selectivity toward the SARS-CoV-2 Spike S1 RBD protein compared to the structural resembling Spike proteins of Bat-CoV, while cytocompatibility assays confirmed the biocompatible character of the SNAs. Given the excellent features of the recently developed MIP-SNAs, we are one step closer to finding efficient but also patient-friendly prevention and treatment solutions for SARS-CoV-2 infection. Beyond immediate applications, this technology offers the potential for broader diagnostic and therapeutic uses against related viral pathogens.

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引用次数: 0
A Primer-Regulated Rolling Circle Amplification (RCA) for Logic-Controlled Multiplexed Enzyme Analysis.
IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-03-17 Epub Date: 2025-02-21 DOI: 10.1021/acsabm.4c01890
Shuiqin Chai, Wanlin Sun, Xin Hou, Shuchen Pei, Yuheng Liu, Kang Luo, Shan Guan, Wenyi Lv

DNA-related enzymes are associated with various diseases and have been potential biomarkers for clinical diagnosis. Developing robust and ultrasensitive methods is extremely favorable for the detection of these biomarkers. To this purpose, a primer-regulated rolling circle amplification (RCA) strategy was ingeniously proposed. Briefly, the RCA primer, which was invalidated with 3'-inverted dT (locked state) and unable to initiate an amplification reaction by phi29 DNA polymerase, was embedded with the recognition substrate of the specific enzyme. In the presence of the target, the recognition and cleavage process of the enzyme prompted the release of the 3'-inverted dT and the regeneration of 3'-OH (unlocked state), satisfying the vital prerequisite for RCA. By adopting this programmable and modular design, the recognition substrate can be either single base sites or a specific sequence for different types of enzymes. This also enables us to conduct single or multiple enzyme detection conveniently, relying on a logic-controlled manner including YES, OR, AND, and AND-OR operations. Overall, the proposed strategy is uniquely insightful and provides a universal tool for multiple analyses of diverse DNA-related enzymes.

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引用次数: 0
Facile Synthesis of Polymeric Nanoprobes for Actively Targeted and High-Performance MR/CT Dual-Modal Imaging of Rheumatoid Arthritis. 用于类风湿性关节炎主动靶向和高性能 MR/CT 双模态成像的聚合物纳米探针的简易合成。
IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-03-17 Epub Date: 2025-02-24 DOI: 10.1021/acsabm.4c01708
Xuan Chen, Junping Ma, Deshen Dai, Kang Wang, Mo Yang, Changqing Yi

This study reports a facile approach for the green synthesis of a high-performance magnetic resonance/computed tomography (MR/CT) dual-modal imaging nanoprobe. The probe, designated as NPs-TCZ, is synthesized via one-step self-assembly of two amphiphilic block copolymers, namely, PEG-DTIPA-TCZ and pal-GGGGHHHHD. The NPs-TCZ exhibits a high longitudinal relaxivity (9.60 mM-1 s-1) and X-ray absorption (58.2 Hu mM-1), as well as excellent water solubility and biocompatibility. The MR/CT dual-modal imaging can synergistically visualize synovial inflammation and bone erosion, which are both important clinical indicators for assessing arthritis severity, enabling sensitive diagnosis and prognostic assessments of rheumatoid arthritis (RA). The active targeting capability of tocilizumab (TCZ) enables the specific accumulation of NPs-TCZ at inflamed joints rather than healthy joints, significantly enhancing the imaging signals and minimizing its potential side effects. In vivo assays using both collagen-induced arthritis mice and acute arthritis mice demonstrate high performance and effectiveness in MR/CT dual-modal imaging of inflamed joints. This study provides insights into not only RA diagnosis in a more accurate manner but also the synthesis of multifunctional nanoprobes in a more robust and mild manner.

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引用次数: 0
Simultaneous Bacteria Sensing and On-Demand Antimicrobial Peptide Release.
IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-03-17 Epub Date: 2025-02-24 DOI: 10.1021/acsabm.4c01862
Mohadeseh Bagherabadi, Celine Feuilloley, Petra J Cameron, Annette Andrieu-Brunsen

A material that was able to simultaneously sense a bacterial presence and to release antimicrobial peptides (AMP) on demand in a tunable amount was developed. Simultaneous sensing and release were achieved by the combination of a bacteria-sensing hydrogel with antimicrobial-peptide-carrying mesoporous silica particles or coatings. The mesoporous silica with a mesopore diameter of 22 nm was functionalized with a covalently grafted green light-sensitive linker, to which antimicrobial peptides were covalently attached. The gelatin-based hydrogel, which contains C14R-functionalized mesoporous silica particles, is designed to respond to bacterial presence as it may occur, e.g., in a wound's microbiological environment. In the presence of bacteria and 0.1% trypsin, a protease enzyme simulating bacterial presence, the hydrogel, deposited in a donut shape, undergoes a shape loss as the bacteria cleave cross-linking bonds within the hydrogel. When observing hydrogel shape loss after 2 h as a readout of a bacterial infection, subsequent irradiation triggers the release of antimicrobial peptides on demand with adjustable concentration-time profiles. The sensing and on-demand release are integrated into commercially available wound dressing fabrics, demonstrating an application proof-of-concept. Characterization using ATR-IR spectroscopy, TGA, and BCA validates the successful fabrication and release. The H1.6P composite released antimicrobial agents, reaching concentrations of up to 298 μg/mL at pH 7.4 from a 300 μL sample. The efficacy of the released C14R against E. coli BL21(DE3) is illustrated. Overall, the multifunctionality of this approach presents a promising step toward on-demand wound care and thus for reducing side effects and antibiotic resistance.

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引用次数: 0
Mucin Coatings Establish Multifunctional Properties on Commercial Sutures.
IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-03-17 Epub Date: 2025-02-27 DOI: 10.1021/acsabm.4c01793
Ufuk Gürer, Di Fan, Zhiyan Xu, Qaisar Nawaz, Jorrit Baartman, Aldo R Boccaccini, Oliver Lieleg

During the wound healing process, complications such as bacterial attachment or inflammation may occur, potentially leading to surgical site infections. To reduce this risk, many commercial sutures contain biocides such as triclosan; however, this chemical has been linked to toxicity and contributes to the occurrence of bacterial resistance. In response to the need for more biocompatible alternatives, we here present an approach inspired by the innate human defense system: utilizing mucin glycoproteins derived from porcine mucus to create more cytocompatible suture coatings with antibiofouling properties. By attaching manually purified mucin to commercially available sutures through a simple and rapid coating process, we obtain sutures with cell-repellent and antibacterial properties toward Gram-positive bacteria. Importantly, our approach preserves the very good mechanical and tribological properties of the sutures while offering options for further modifications: the mucin matrix can either be condensed for controlled localized drug release or covalently functionalized with inorganic nanoparticles for hard tissue applications, which allows for tailoring a commercial suture for specific biomedical use cases.

在伤口愈合过程中,可能会出现细菌附着或炎症等并发症,从而可能导致手术部位感染。为了降低这种风险,许多商用缝合线都含有三氯生等杀菌剂;然而,这种化学物质与毒性有关,而且会导致细菌产生抗药性。为了满足人们对更具生物相容性替代品的需求,我们在此介绍一种受人类先天防御系统启发的方法:利用从猪粘液中提取的粘蛋白糖蛋白来制造更具有细胞相容性和抗生物污染特性的缝合线涂层。通过简单快速的涂层工艺将人工纯化的粘蛋白附着在市售缝合线上,我们获得了对革兰氏阳性菌具有细胞排斥和抗菌特性的缝合线。重要的是,我们的方法保留了缝合线非常好的机械和摩擦学特性,同时还提供了进一步改性的选择:粘蛋白基质既可以凝结以控制局部药物释放,也可以与无机纳米粒子共价功能化以用于硬组织应用,从而为特定的生物医学用途定制商用缝合线。
{"title":"Mucin Coatings Establish Multifunctional Properties on Commercial Sutures.","authors":"Ufuk Gürer, Di Fan, Zhiyan Xu, Qaisar Nawaz, Jorrit Baartman, Aldo R Boccaccini, Oliver Lieleg","doi":"10.1021/acsabm.4c01793","DOIUrl":"10.1021/acsabm.4c01793","url":null,"abstract":"<p><p>During the wound healing process, complications such as bacterial attachment or inflammation may occur, potentially leading to surgical site infections. To reduce this risk, many commercial sutures contain biocides such as triclosan; however, this chemical has been linked to toxicity and contributes to the occurrence of bacterial resistance. In response to the need for more biocompatible alternatives, we here present an approach inspired by the innate human defense system: utilizing mucin glycoproteins derived from porcine mucus to create more cytocompatible suture coatings with antibiofouling properties. By attaching manually purified mucin to commercially available sutures through a simple and rapid coating process, we obtain sutures with cell-repellent and antibacterial properties toward Gram-positive bacteria. Importantly, our approach preserves the very good mechanical and tribological properties of the sutures while offering options for further modifications: the mucin matrix can either be condensed for controlled localized drug release or covalently functionalized with inorganic nanoparticles for hard tissue applications, which allows for tailoring a commercial suture for specific biomedical use cases.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"2263-2274"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Piezoelectricity Promotes 3D-Printed BTO/β-TCP Composite Scaffolds with Excellent Osteogenic Performance.
IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-03-17 Epub Date: 2025-02-27 DOI: 10.1021/acsabm.4c01754
Suyun Li, Yanbo Shan, Jingyi Chen, Ruyue Su, Lisheng Zhao, Rujie He, Ying Li

Piezoelectricity is reported to be able to promote bone scaffolds with excellent osteogenic performance. Herein, barium titanate/β-tricalcium phosphate (BTO/β-TCP) piezoelectric composite scaffolds were 3D printed, and their osteogenic performances were investigated in detail. The fabrication of BTO/β-TCP piezoelectric composite scaffolds employed cutting-edge DLP 3D printing technology. The scaffolds, featuring a triply periodic minimal surface (TPMS) design with a porosity of 60%, offered a unique structural framework. A comprehensive assessment of the composition, piezoelectric properties, and mechanical characteristics of the BTO/β-TCP scaffolds was conducted. Notably, an increase in the BTO volume fraction from 50 to 80 vol % within the scaffolds led to a reduction in compressive strength, decreasing from 2.47 to 1.74 MPa. However, this variation was accompanied by a substantial enhancement in the piezoelectric constant d33, soaring from 1.4 pC/N to 21.6 pC/N. Utilizing mouse osteoblasts (MC3T3-E1) in a live/dead cell staining assay, under the influence of external ultrasound, demonstrated the commendable biocompatibility of these piezoelectric composite ceramic bone scaffolds. Furthermore, thorough analyses of alkaline phosphatase (ALP) activity and polymerase chain reaction (PCR) findings provided compelling evidence of the scaffolds' superior osteogenic properties, underpinning their effectiveness at the cellular protein and gene levels. In conclusion, this study offers a groundbreaking strategy for the employment of BTO/β-TCP piezoelectric composite scaffolds in bone implant applications, harnessing their unique blend of biocompatibility, piezoelectricity, and osteogenic potential.

{"title":"Piezoelectricity Promotes 3D-Printed BTO/β-TCP Composite Scaffolds with Excellent Osteogenic Performance.","authors":"Suyun Li, Yanbo Shan, Jingyi Chen, Ruyue Su, Lisheng Zhao, Rujie He, Ying Li","doi":"10.1021/acsabm.4c01754","DOIUrl":"10.1021/acsabm.4c01754","url":null,"abstract":"<p><p>Piezoelectricity is reported to be able to promote bone scaffolds with excellent osteogenic performance. Herein, barium titanate/β-tricalcium phosphate (BTO/β-TCP) piezoelectric composite scaffolds were 3D printed, and their osteogenic performances were investigated in detail. The fabrication of BTO/β-TCP piezoelectric composite scaffolds employed cutting-edge DLP 3D printing technology. The scaffolds, featuring a triply periodic minimal surface (TPMS) design with a porosity of 60%, offered a unique structural framework. A comprehensive assessment of the composition, piezoelectric properties, and mechanical characteristics of the BTO/β-TCP scaffolds was conducted. Notably, an increase in the BTO volume fraction from 50 to 80 vol % within the scaffolds led to a reduction in compressive strength, decreasing from 2.47 to 1.74 MPa. However, this variation was accompanied by a substantial enhancement in the piezoelectric constant d<sub>33</sub>, soaring from 1.4 pC/N to 21.6 pC/N. Utilizing mouse osteoblasts (MC3T3-E1) in a live/dead cell staining assay, under the influence of external ultrasound, demonstrated the commendable biocompatibility of these piezoelectric composite ceramic bone scaffolds. Furthermore, thorough analyses of alkaline phosphatase (ALP) activity and polymerase chain reaction (PCR) findings provided compelling evidence of the scaffolds' superior osteogenic properties, underpinning their effectiveness at the cellular protein and gene levels. In conclusion, this study offers a groundbreaking strategy for the employment of BTO/β-TCP piezoelectric composite scaffolds in bone implant applications, harnessing their unique blend of biocompatibility, piezoelectricity, and osteogenic potential.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"2204-2214"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iron Oxide Nanoparticles as Enhancers for Radiotherapy of Tumors.
IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-03-17 Epub Date: 2025-03-04 DOI: 10.1021/acsabm.4c01978
Maria V Shestovskaya, Anna L Luss, Olga A Bezborodova, Yulia B Venidiktova, Maria S Vorontsova, Elizaveta R Vlaskina, Kirill K Kushnerev, Pavel P Kulikov, Valentin V Makarov, Vladimir S Yudin, Anton A Keskinov

This research aimed to evaluate the potency of preparation based on heparinized iron oxide nanoparticles (hIONPs) in combination with radiation therapy, including magnetic delivery via the applied magnetic field (AMF), in sarcoma and cervical cancer models. For in vitro studies, cells of rhabdomyosarcoma (RD), fibrosarcoma (HT1080), and cervical cancer (HeLa S3) were treated with hIONPs and analyzed for survival rate and hIONP uptake. Then, cell morphology, cell cycle, increase of reactive oxygen species, mitochondria depolarization, and ability to form colonies were assessed for combined treatment (hIONPs + 3Gy). For in vivo research, hIONPs were administered once in the hybrids of CBAxC57Bl/6j mice, grafted with sarcoma (S37) and cervical cancer (CC5) strains. The ultimate in vivo treatment modes were: (1) i.v. hIONPs (14 μg/kg) + 5 Gy; (2) i.v. hIONPs (14 μg/kg) + AMF + 5 Gy; and (3) i.t. hIONPs (2,8 μg/kg) + 5 Gy. The overall survival rates, increase in life expectancy, inhibition of tumor growth (tumor growth inhibition), and degree of inhibition (T/C) were determined, and pathomorphological changes were assessed in experimental groups. The combined treatment in vitro (hIONPs + 3Gy) promotes multiple tumor cell death with high-severity peroxide effects compared with other groups. The sarcoma cells were more sensitive than cervical cancer cells. For in vivo, an enhancing effect was revealed by the combination of radiotherapy and magnetic-delivered hIONPs. For S37 tumor, the treatment regimen was characterized as having a high antitumor effect, ≪++++ ≫, with a 20% cure rate of mice. For the CC5 tumor, the effect was accompanied by the inhibition of tumor growth, an increase in the life expectancy of animals, and was characterized as a significant antitumor effect, ≪+++/++ ≫. From the data obtained, it can be concluded that the radiosensitizing potential of hIONPs may be taken as a basis of combined radiation treatment protocols.

{"title":"Iron Oxide Nanoparticles as Enhancers for Radiotherapy of Tumors.","authors":"Maria V Shestovskaya, Anna L Luss, Olga A Bezborodova, Yulia B Venidiktova, Maria S Vorontsova, Elizaveta R Vlaskina, Kirill K Kushnerev, Pavel P Kulikov, Valentin V Makarov, Vladimir S Yudin, Anton A Keskinov","doi":"10.1021/acsabm.4c01978","DOIUrl":"10.1021/acsabm.4c01978","url":null,"abstract":"<p><p>This research aimed to evaluate the potency of preparation based on heparinized iron oxide nanoparticles (hIONPs) in combination with radiation therapy, including magnetic delivery via the applied magnetic field (AMF), in sarcoma and cervical cancer models. For in vitro studies, cells of rhabdomyosarcoma (RD), fibrosarcoma (HT1080), and cervical cancer (HeLa S3) were treated with hIONPs and analyzed for survival rate and hIONP uptake. Then, cell morphology, cell cycle, increase of reactive oxygen species, mitochondria depolarization, and ability to form colonies were assessed for combined treatment (hIONPs + 3Gy). For in vivo research, hIONPs were administered once in the hybrids of CBAxC57Bl/6j mice, grafted with sarcoma (S37) and cervical cancer (CC5) strains. The ultimate in vivo treatment modes were: (1) i.v. hIONPs (14 μg/kg) + 5 Gy; (2) i.v. hIONPs (14 μg/kg) + AMF + 5 Gy; and (3) i.t. hIONPs (2,8 μg/kg) + 5 Gy. The overall survival rates, increase in life expectancy, inhibition of tumor growth (tumor growth inhibition), and degree of inhibition (T/C) were determined, and pathomorphological changes were assessed in experimental groups. The combined treatment in vitro (hIONPs + 3Gy) promotes multiple tumor cell death with high-severity peroxide effects compared with other groups. The sarcoma cells were more sensitive than cervical cancer cells. For in vivo, an enhancing effect was revealed by the combination of radiotherapy and magnetic-delivered hIONPs. For S37 tumor, the treatment regimen was characterized as having a high antitumor effect, ≪++++ ≫, with a 20% cure rate of mice. For the CC5 tumor, the effect was accompanied by the inhibition of tumor growth, an increase in the life expectancy of animals, and was characterized as a significant antitumor effect, ≪+++/++ ≫. From the data obtained, it can be concluded that the radiosensitizing potential of hIONPs may be taken as a basis of combined radiation treatment protocols.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"2535-2547"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to "Effect of Chirality and Amphiphilicity on the Antimicrobial Activity of Tripodal Lysine-Based Peptides".
IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2025-03-17 Epub Date: 2025-02-07 DOI: 10.1021/acsabm.5c00130
Anindyasundar Adak, Valeria Castelletto, Lucas de Mello, Bruno Mendes, Glyn Barrett, Jani Seitsonen, Ian W Hamley
{"title":"Correction to \"Effect of Chirality and Amphiphilicity on the Antimicrobial Activity of Tripodal Lysine-Based Peptides\".","authors":"Anindyasundar Adak, Valeria Castelletto, Lucas de Mello, Bruno Mendes, Glyn Barrett, Jani Seitsonen, Ian W Hamley","doi":"10.1021/acsabm.5c00130","DOIUrl":"10.1021/acsabm.5c00130","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"2629-2630"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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