Pub Date : 2016-10-10DOI: 10.18869/ACADPUB.HMS.22.4.353
H. Jafarimanesh, F. Rafiei, Mokhtar Mahmoudi, P. Asgari, P. Matourypour, ebrahim sobhani
Comparing the Pain and Anxiety of Intravenous Access in Supine and Sitting Positions Author(s): P. Matory por , M. Mahmoudi * , H. Mafari manesh , S. Ebrahim Pour , F. Rafiei , P. Asgari Abstract: Aims: The installation of intravenous catheter is an unpleasant and painful experience for many patients. Then, it is necessary to provide new methods to either reduce or remove pain in the patients’ injection point. The aim of this study was to investigate the effects of positioning (either sitting or lying) during the installation of intravenous catheter on pain level and the following anxiety in the patients. Instrument & Methods: In the two-blinded clinical trial study, 60 patients hospitalized in the internal wards of Arak Amir-Al-Momenin Hospital were studied in 2015. The subjects selected via available method were divided into two groups including sitting and supine groups based on the simple random allocation. The pain severity and anxiety severity indices were investigated in both groups before and after the venipuncture based on the visual analogue scale (VAS). Data was analyzed by SPSS 20 software using Chi-square, paired-T, and independent T tests. Findings: Mean scores of anxiety before the venipuncture in both groups were not significantly different (p>0.05). Nevertheless, after the venipuncture, mean anxiety score and mean pain score in sitting group were significantly more than supine group (p=0.0001). In addition, mean scores of anxiety before and after the venipuncture in the supine group were significantly different (p=0.0001). However, no significant difference was observed between the scores before and after the venipuncture in sitting group (p>0.05). Conclusion: During the installation of intravenous catheter, the supine position can reduce the pain level and the following anxiety in the patients compared to the sitting position. Keywords: Anxiety ,Pain , Supine Position , Injections, Intravenous
作者(5):P. por, M. Mahmoudi *， H. Mafari manesh, s. Ebrahim Pour, F. Rafiei, P. Asgari摘要:目的:静脉置管对许多患者来说是一种不愉快和痛苦的经历。然后，有必要提供新的方法来减轻或消除患者注射点的疼痛。本研究的目的是探讨静脉置管过程中体位(坐或卧)对患者疼痛程度和随后焦虑的影响。仪器与方法:采用双盲临床试验研究，选取2015年Arak Amir-Al-Momenin医院内科病房住院的60例患者为研究对象。采用简单随机分配的方法将实验对象分为坐位组和仰卧组。采用视觉模拟评分(VAS)对两组患者静脉穿刺前后的疼痛严重程度和焦虑严重程度进行评分。数据分析采用SPSS 20软件，采用卡方检验、配对T检验和独立T检验。结果:两组患者静脉穿刺前焦虑平均评分差异无统计学意义(p < 0.05)。然而，静脉穿刺后，坐位组的平均焦虑评分和平均疼痛评分显著高于仰卧位组(p=0.0001)。此外，仰卧位组在静脉穿刺前后的平均焦虑评分差异有统计学意义(p=0.0001)。坐位组静脉穿刺前后评分差异无统计学意义(p < 0.05)。结论:在静脉置管过程中，与坐位相比，仰卧位可减轻患者的疼痛程度和后续焦虑。关键词:焦虑，疼痛，仰卧位，注射，静脉注射
{"title":"Comparing the Pain and Anxiety of Intravenous Access in Supine and Sitting Positions","authors":"H. Jafarimanesh, F. Rafiei, Mokhtar Mahmoudi, P. Asgari, P. Matourypour, ebrahim sobhani","doi":"10.18869/ACADPUB.HMS.22.4.353","DOIUrl":"https://doi.org/10.18869/ACADPUB.HMS.22.4.353","url":null,"abstract":"Comparing the Pain and Anxiety of Intravenous Access in Supine and Sitting Positions \u0000 \u0000 \u0000Author(s): \u0000P. Matory por , M. Mahmoudi * , H. Mafari manesh , S. Ebrahim Pour , F. Rafiei , P. Asgari \u0000 \u0000 \u0000Abstract: \u0000Aims: The installation of intravenous catheter is an unpleasant and painful experience for many patients. Then, it is necessary to provide new methods to either reduce or remove pain in the patients’ injection point. The aim of this study was to investigate the effects of positioning (either sitting or lying) during the installation of intravenous catheter on pain level and the following anxiety in the patients. \u0000 \u0000Instrument & Methods: In the two-blinded clinical trial study, 60 patients hospitalized in the internal wards of Arak Amir-Al-Momenin Hospital were studied in 2015. The subjects selected via available method were divided into two groups including sitting and supine groups based on the simple random allocation. The pain severity and anxiety severity indices were investigated in both groups before and after the venipuncture based on the visual analogue scale (VAS). Data was analyzed by SPSS 20 software using Chi-square, paired-T, and independent T tests. \u0000 \u0000Findings: Mean scores of anxiety before the venipuncture in both groups were not significantly different (p>0.05). Nevertheless, after the venipuncture, mean anxiety score and mean pain score in sitting group were significantly more than supine group (p=0.0001). In addition, mean scores of anxiety before and after the venipuncture in the supine group were significantly different (p=0.0001). However, no significant difference was observed between the scores before and after the venipuncture in sitting group (p>0.05). \u0000 \u0000Conclusion: During the installation of intravenous catheter, the supine position can reduce the pain level and the following anxiety in the patients compared to the sitting position. \u0000 \u0000Keywords: \u0000Anxiety ,Pain , Supine Position , Injections, Intravenous","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133096219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-10-10DOI: 10.18869/ACADPUB.HMS.22.4.291
زهرا پیرو, عبدالحسین پرنو, پیام ساری اصلانی, رسول اسلامی
{"title":"تاثیر تمرین هوازی با شدت متوسط بر شاخصهای سردرد میگرنی و بهبود کیفیت زندگی در زنان میگرنی","authors":"زهرا پیرو, عبدالحسین پرنو, پیام ساری اصلانی, رسول اسلامی","doi":"10.18869/ACADPUB.HMS.22.4.291","DOIUrl":"https://doi.org/10.18869/ACADPUB.HMS.22.4.291","url":null,"abstract":"","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128950286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-10-10DOI: 10.18869/ACADPUB.HMS.22.4.329
V. Sobhani, M. Mohammadi, H. Shirvani, A. Amini
Aims: Following the sport activities, the blood homeostasis system, being affected by fibrinolysis and coagulation factors, is changed. The aim of this study was to investigate the effects of high-intensity interval and concurrent (aerobic-resistance) long-term sport courses on the blood fibrinolysis and coagulation parameters in healthy non-athlete young persons. Materials & Methods: In the semi-experimental study, 30 healthy non-athlete young men were studied in Saqez in 2014. The subjects, selected via simple available sampling method, were randomly divided into three groups including concurrent (aerobic-resistance) trainings, high-intensity interval trainings, and control groups. 8-week trainings (3 times a week) were conducted in both concurrent and high-intensity interval groups. Blood sampling was done before the first session and 30 minutes after the last training session. Data was analyzed by SPSS 19 software using dependent T, one-way ANOVA, and Tukey’s post-hoc tests. Findings: After the training intervention, the number of platelits and the fibrinogen level significantly decreased in concurrent group. In addition, prothrombin time in high-intensity interval group and the D-dimer level in both training groups significantly increased (p<0.05). The D-dimer concentrations in control and high-intensity interval groups were significantly different. In addition, the number of platelets in concurrent group was significantly different from both control and high-intensity interval groups (p<0.05). Conclusion: 8-week high-intensity interval and concurrent trainings reduce the promoter coagulation activity in the helthy non-athlete young men, while increase the fibrinolytic activity.
{"title":"Long-Term Effect of High-Intensity Interval and Concurrent Exercise on Blood Coagulation and Fibrinolysis Parameters in Non-Athlete Healthy Young Men","authors":"V. Sobhani, M. Mohammadi, H. Shirvani, A. Amini","doi":"10.18869/ACADPUB.HMS.22.4.329","DOIUrl":"https://doi.org/10.18869/ACADPUB.HMS.22.4.329","url":null,"abstract":"Aims: Following the sport activities, the blood homeostasis system, being affected by fibrinolysis and coagulation factors, is changed. The aim of this study was to investigate the effects of high-intensity interval and concurrent (aerobic-resistance) long-term sport courses on the blood fibrinolysis and coagulation parameters in healthy non-athlete young persons. Materials & Methods: In the semi-experimental study, 30 healthy non-athlete young men were studied in Saqez in 2014. The subjects, selected via simple available sampling method, were randomly divided into three groups including concurrent (aerobic-resistance) trainings, high-intensity interval trainings, and control groups. 8-week trainings (3 times a week) were conducted in both concurrent and high-intensity interval groups. Blood sampling was done before the first session and 30 minutes after the last training session. Data was analyzed by SPSS 19 software using dependent T, one-way ANOVA, and Tukey’s post-hoc tests. Findings: After the training intervention, the number of platelits and the fibrinogen level significantly decreased in concurrent group. In addition, prothrombin time in high-intensity interval group and the D-dimer level in both training groups significantly increased (p<0.05). The D-dimer concentrations in control and high-intensity interval groups were significantly different. In addition, the number of platelets in concurrent group was significantly different from both control and high-intensity interval groups (p<0.05). Conclusion: 8-week high-intensity interval and concurrent trainings reduce the promoter coagulation activity in the helthy non-athlete young men, while increase the fibrinolytic activity.","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125808919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-15DOI: 10.18869/ACADPUB.HMS.22.3.215
H. Marefati, N. Vizvari, M. Hosseinzade, L. Z. Dashtkhaki, Exir Vizvari
Aims: As factors that affect the pulmonary functioning, different climatic conditions and physical activities can produce respiratory diseases. The aim of this study was to compare the effects of physical activities on the pulmonary functioning in 12-14 years old females in two different Kerman and Gorgan climatic conditions. Materials & Methods: In the semi-experimental study, 128 female students of the elementary schools, aged between 12 and 14 years, were studied in Kerman and Gorgan (n=64 per city) in 2013. The subjects were selected through random cluster method. The pulmonary functioning test was done before, immediately after, 7min after, and 20min after the physical activities. The peak expiratory flow (PEF), the expiratory volume in 1 second (FEV1), the forced vital capacity (FVC), the maximum expiratory flow at 50% of forced vital capacity (MEF50%) were measured. More than 15% reductions in FEV1 and PEF after the activities were explained as Exercise Induced Asthma. Data was analyzed by SPSS 19 software using repeated measurement of variences and Chi-square tests. Findings: There was no significant difference in either FEV1 or PEF between Kerman and Gorgan cities (p>0.05). Nevertheless, there was a significant difference in the mean FVC between the cities (p=0.001). In total, there was more pulmonary-functioning drop after the activities in Kerman than Gorgan. Conclusion: More than average severe physical activities reduces the pulmonary capacity in 12-14 years old female, which cool and dry climate leads to more drop in the pulmonary functioning after the activities, as well as the continuance of the drop, than the wet climate.
{"title":"Comparison of the Lung Function in Response to Physical Activity in Two Different Climates","authors":"H. Marefati, N. Vizvari, M. Hosseinzade, L. Z. Dashtkhaki, Exir Vizvari","doi":"10.18869/ACADPUB.HMS.22.3.215","DOIUrl":"https://doi.org/10.18869/ACADPUB.HMS.22.3.215","url":null,"abstract":"Aims: As factors that affect the pulmonary functioning, different climatic conditions and physical activities can produce respiratory diseases. The aim of this study was to compare the effects of physical activities on the pulmonary functioning in 12-14 years old females in two different Kerman and Gorgan climatic conditions. Materials & Methods: In the semi-experimental study, 128 female students of the elementary schools, aged between 12 and 14 years, were studied in Kerman and Gorgan (n=64 per city) in 2013. The subjects were selected through random cluster method. The pulmonary functioning test was done before, immediately after, 7min after, and 20min after the physical activities. The peak expiratory flow (PEF), the expiratory volume in 1 second (FEV1), the forced vital capacity (FVC), the maximum expiratory flow at 50% of forced vital capacity (MEF50%) were measured. More than 15% reductions in FEV1 and PEF after the activities were explained as Exercise Induced Asthma. Data was analyzed by SPSS 19 software using repeated measurement of variences and Chi-square tests. Findings: There was no significant difference in either FEV1 or PEF between Kerman and Gorgan cities (p>0.05). Nevertheless, there was a significant difference in the mean FVC between the cities (p=0.001). In total, there was more pulmonary-functioning drop after the activities in Kerman than Gorgan. Conclusion: More than average severe physical activities reduces the pulmonary capacity in 12-14 years old female, which cool and dry climate leads to more drop in the pulmonary functioning after the activities, as well as the continuance of the drop, than the wet climate.","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127735863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-15DOI: 10.18869/acadpub.hms.22.3.253
سیده کبری سیدآبکناری, فریبر فائقی, آروین آریان
Aims: Endometrial cancer is the most common malignancy of the female reproductive tract. As the prognosis factors, the determination of exact cancer stage and the differentiation of the lymph nodes plays a role in the selection of treatment plan and the rate of patient’s survival. The aim of this study was to investigate the diagnosis accuracy of dynamic and diffusion imaging techniques in the endometrial cancer staging as well as the differentiation of metastatic and non-metastatic lymph nodes. Materials & Methods: In this prospective study, 30 patients with endometrial cancer were studied in MRI ward of the imaging center of Imam Khomeini Hospital in Tehran in 2013-14. The subjects, selected by purposeful sampling method, underwent the pelvis imaging before the surgery. T1W and T2W scenes, the dynamic technique in phases including 25, 60, 120, and 240 seconds after the injection, and the diffusion technique (b= zero and 1000 s/mm) were used in the imaging. Data was analyzed by SPSS 22 software using kappa statistic, two-independent T test, and one-way ANOVA. Findings: The agreement rate between the results of radiology and pathology in the determination of the different cancer stages was approximately 0.8, showing a good and considerable result (p<0.001). The diagnostic authenticity rate of the dynamic and diffusion techniques was 0.83. The results of radiology and pathology were completely consistent regarding the differentiation between the metastatic and non-metastatic lymph nodes. In different cancer stages, as well as in the metastatic and non-metastatic lymph nodes, the mean age and number of fertility were not significantly different (p>0.05). Conclusion: In the differentiation between the metastatic and non-metastatic lymph nodes in patients with endometrial cancer, the diagnostic accuracy is increased by the diffusion techniques utilizing the routine scenes and the injection.
{"title":"Diagnostic Accuracy of Diffusion Weighted Imaging and Dynamic Imaging Techniques in Endometrial and Lymph Nodes Cancer Staging","authors":"سیده کبری سیدآبکناری, فریبر فائقی, آروین آریان","doi":"10.18869/acadpub.hms.22.3.253","DOIUrl":"https://doi.org/10.18869/acadpub.hms.22.3.253","url":null,"abstract":"Aims: Endometrial cancer is the most common malignancy of the female reproductive tract. As the prognosis factors, the determination of exact cancer stage and the differentiation of the lymph nodes plays a role in the selection of treatment plan and the rate of patient’s survival. The aim of this study was to investigate the diagnosis accuracy of dynamic and diffusion imaging techniques in the endometrial cancer staging as well as the differentiation of metastatic and non-metastatic lymph nodes. Materials & Methods: In this prospective study, 30 patients with endometrial cancer were studied in MRI ward of the imaging center of Imam Khomeini Hospital in Tehran in 2013-14. The subjects, selected by purposeful sampling method, underwent the pelvis imaging before the surgery. T1W and T2W scenes, the dynamic technique in phases including 25, 60, 120, and 240 seconds after the injection, and the diffusion technique (b= zero and 1000 s/mm) were used in the imaging. Data was analyzed by SPSS 22 software using kappa statistic, two-independent T test, and one-way ANOVA. Findings: The agreement rate between the results of radiology and pathology in the determination of the different cancer stages was approximately 0.8, showing a good and considerable result (p<0.001). The diagnostic authenticity rate of the dynamic and diffusion techniques was 0.83. The results of radiology and pathology were completely consistent regarding the differentiation between the metastatic and non-metastatic lymph nodes. In different cancer stages, as well as in the metastatic and non-metastatic lymph nodes, the mean age and number of fertility were not significantly different (p>0.05). Conclusion: In the differentiation between the metastatic and non-metastatic lymph nodes in patients with endometrial cancer, the diagnostic accuracy is increased by the diffusion techniques utilizing the routine scenes and the injection.","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133336249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-15DOI: 10.18869/ACADPUB.HMS.22.3.171
G. Shabanian, M. Rafie, S. Heidari-Soureshjani, A. Shabanian, M. Shabanian
Aims Propofol is the most widely used intravenous anesthetic medication. It is necessary to assess the doses of the medication to determine proper anesthetic depth and to prevent its side-effects. The aim of this study was to compare 1 and 2.5mg/Kg doses of propofol in hemodynamic changes, myoclonus degree, and bi-spectral index (BIS) monitoring level in patients under anesthetic induction. Materials & Methods In the two-blind random clinical trial study, 92 patients being candidate for surgery wit general anesthesia induction were studied in Shahr-e Kord Kashani Center in 2013. The subjects, selected via simple sampling method, were randomly divided into two groups. The first and the second groups were received 1 and 2.5mg/kg doses of propofol, respectively. Hemodynamic, myoclonus, and BIS indices were measured at four different times in the groups. Data was analyzed by SPSS 17 using independent T and Chi-square tests, as well as repeated ANOVA and Fisher’s test. Findings There was no significant difference between the groups in the hemodynamic variables such as systolic and diastolic blood pressure, mean arterial blood pressure, pulse rate, and BIS (p>0.05). In addition, the change rates of the variables were the same. Nevertheless, there was a significant difference between the groups in the pulse change rate (p=0.032). There was no significant difference between the groups in myoclonus (p>0.05). Conclusion The hemodynamic changes and the changes in myoclonus degree and BIS are the same in 1 and 2.5mg/kg doses of propofol in the patients undergoing anesthetic induction.
目的异丙酚是目前应用最广泛的静脉麻醉药物。有必要评估药物的剂量，以确定适当的麻醉深度和防止其副作用。本研究的目的是比较1和2.5mg/Kg剂量异丙酚对麻醉诱导患者血流动力学变化、肌阵挛程度和双谱指数(BIS)监测水平的影响。材料与方法双盲随机临床试验研究选取Shahr-e Kord Kashani中心2013年全麻诱导手术候诊患者92例。采用简单抽样法，随机分为两组。第一组和第二组分别给予1和2.5mg/kg剂量的异丙酚。血流动力学、肌阵挛和BIS指数在4个不同时间测量。数据分析采用SPSS 17，采用独立T检验、卡方检验、重复方差分析和Fisher检验。结果两组间收缩压、舒张压、平均动脉压、脉搏率、BIS等血流动力学指标比较，差异均无统计学意义(p>0.05)。此外，变量的变化率是相同的。但两组间脉搏变化率差异有统计学意义(p=0.032)。肌阵挛组间差异无统计学意义(p>0.05)。结论1、2.5mg/kg异丙酚对麻醉诱导患者血流动力学变化、肌颤度及BIS变化相同。
{"title":"Comparison of Hemodynamic Variations, Bispectral Index and Myoclonus Score of Propofol Dosage in Anesthesia Induced Patients","authors":"G. Shabanian, M. Rafie, S. Heidari-Soureshjani, A. Shabanian, M. Shabanian","doi":"10.18869/ACADPUB.HMS.22.3.171","DOIUrl":"https://doi.org/10.18869/ACADPUB.HMS.22.3.171","url":null,"abstract":"Aims Propofol is the most widely used intravenous anesthetic medication. It is necessary \u0000to assess the doses of the medication to determine proper anesthetic depth and to prevent \u0000its side-effects. The aim of this study was to compare 1 and 2.5mg/Kg doses of propofol in \u0000hemodynamic changes, myoclonus degree, and bi-spectral index (BIS) monitoring level in \u0000patients under anesthetic induction. \u0000Materials & Methods In the two-blind random clinical trial study, 92 patients being candidate \u0000for surgery wit general anesthesia induction were studied in Shahr-e Kord Kashani Center in \u00002013. The subjects, selected via simple sampling method, were randomly divided into two groups. \u0000The first and the second groups were received 1 and 2.5mg/kg doses of propofol, respectively. \u0000Hemodynamic, myoclonus, and BIS indices were measured at four different times in the groups. \u0000Data was analyzed by SPSS 17 using independent T and Chi-square tests, as well as repeated \u0000ANOVA and Fisher’s test. \u0000Findings There was no significant difference between the groups in the hemodynamic \u0000variables such as systolic and diastolic blood pressure, mean arterial blood pressure, \u0000pulse rate, and BIS (p>0.05). In addition, the change rates of the variables were the same. \u0000Nevertheless, there was a significant difference between the groups in the pulse change rate \u0000(p=0.032). There was no significant difference between the groups in myoclonus (p>0.05). \u0000Conclusion The hemodynamic changes and the changes in myoclonus degree and BIS are the \u0000same in 1 and 2.5mg/kg doses of propofol in the patients undergoing anesthetic induction.","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124332089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-10DOI: 10.18869/ACADPUB.HMS.22.3.229
M. Hajinezhad, Shabnam Hajian, S. Saghayei, A. Samzadeh‐Kermani, R. Nabavi
Aims: New medications with less side-effect are increasingly noticed now a day. L-Carnitine and Acetyl L-Carnitine reduce the secondary side-effects of Type I diabetes. The aim of this study was to investigate the effects of oral administration of the materials on the blood glucose and the lipid per-oxidation of the liver and brain tissues in the diabetic rats. Materials & Methods: In the experimental study, 50 male Wistar rats were studied. The rats were randomly divided into five groups including control (the healthy rats), negative control (the diabetic rats), and three treatment diabetic groups. The diabetic groups received 110mg/Kg alloxan via injection to become diabetic. The treatment groups received L-Carnitine, Acetyl L-Carnetine, and LCarnetine with Acetyl L-Carnetine (300mg/Kg) as gavage for 30 days. The lipid per-oxidation, the serum glucose, the lipid profile, and the liver enzymes were measured at the end of the experiment. Data was analyzed using one-way ANOVA followed by Tukey complementary test. Findings: The fasting blood concentration, triglyceride, cholesterol, creatinine, the serum liver enzymes, and the level of the liver tissue malondialdehyde significantly decreased in treatment diabetic group than diabetic group without any treatment, while HDL level increased as well (p<0.05). The brain tissue malondialdehyde and the serum HDL decreased and increased due to the administration of Acetyl L-Carnitine, respectively. Nevertheless, it affected no other parameter significantly. The positive effects of L-Carnitine were reduced by the administration of Acetyl L-Carnitin with L-Carnitine. Conclusion: The administration of L-Carnitine further reduces the secondary side-effects of diabetes than Acetyl L-Carnitine. In addition, simultaneous administration of the materials is not recommended.
{"title":"Comparison the Protective Effects of L-Carnitine and Acetyl L-Carnitine on Blood Glucose and Lipid Peroxidation Level in Diabetic Rats","authors":"M. Hajinezhad, Shabnam Hajian, S. Saghayei, A. Samzadeh‐Kermani, R. Nabavi","doi":"10.18869/ACADPUB.HMS.22.3.229","DOIUrl":"https://doi.org/10.18869/ACADPUB.HMS.22.3.229","url":null,"abstract":"Aims: New medications with less side-effect are increasingly noticed now a day. L-Carnitine and Acetyl L-Carnitine reduce the secondary side-effects of Type I diabetes. The aim of this study was to investigate the effects of oral administration of the materials on the blood glucose and the lipid per-oxidation of the liver and brain tissues in the diabetic rats. Materials & Methods: In the experimental study, 50 male Wistar rats were studied. The rats were randomly divided into five groups including control (the healthy rats), negative control (the diabetic rats), and three treatment diabetic groups. The diabetic groups received 110mg/Kg alloxan via injection to become diabetic. The treatment groups received L-Carnitine, Acetyl L-Carnetine, and LCarnetine with Acetyl L-Carnetine (300mg/Kg) as gavage for 30 days. The lipid per-oxidation, the serum glucose, the lipid profile, and the liver enzymes were measured at the end of the experiment. Data was analyzed using one-way ANOVA followed by Tukey complementary test. Findings: The fasting blood concentration, triglyceride, cholesterol, creatinine, the serum liver enzymes, and the level of the liver tissue malondialdehyde significantly decreased in treatment diabetic group than diabetic group without any treatment, while HDL level increased as well (p<0.05). The brain tissue malondialdehyde and the serum HDL decreased and increased due to the administration of Acetyl L-Carnitine, respectively. Nevertheless, it affected no other parameter significantly. The positive effects of L-Carnitine were reduced by the administration of Acetyl L-Carnitin with L-Carnitine. Conclusion: The administration of L-Carnitine further reduces the secondary side-effects of diabetes than Acetyl L-Carnitine. In addition, simultaneous administration of the materials is not recommended.","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116182220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-10DOI: 10.18869/ACADPUB.HMS.22.3.221
M. Siavashi, R. Ahmadi
Aims: The exposure to chemical materials and colors affects thyroid gland functions. The aim of this study was to investigate the effects of fume inhalation of oil-based paints on the serum level of thyroid hormones in female and male rats. Materials & Methods: In the experimental study, 15 male and 15 female Wistar rats were studied. The rats were divided into six 5-rat groups including a control group and groups with either 1or 8-hour a day exposure to the paint fumes by gender division. The serum levels of T3, T4, and TSH thyroid hormones were measured after 10 weeks. Data was analyzed by SPSS 20 software using two-way ANOVA and Tukey’s post-hoc. Findings: Mean values of T3 and T4 hormones were significantly reduced in both 1and 8-hour male and female groups than control group (p<0.001). In addition, the more the inhalation time, the more the reduction was. Any reduction in T3 in females in 1-hour (p<0.001) and 8–hour (p<0.05) groups was significantly more than the males. Nevertheless, a significant reduction in T4 was only in 1-hour group (p<0.001). Mean TSH hormone was significantly increased due to the inhalation of paint fume than control group (p<0.001). In addition, such an increase was significant in the female rats in 8-hour group than the male group (p<0.01). Conclusion: The inhalation of oil-based paint fume leads to a reduction in the serum levels of T3 and T4 thyroid hormones, while increases TSH serum level. Such an effect is stronger in the females.
{"title":"Effect of Oil Paint Fumes Inhalation on the Level of Serum Thyroid Hormones and Thyroid Stimulating Hormone in Rats","authors":"M. Siavashi, R. Ahmadi","doi":"10.18869/ACADPUB.HMS.22.3.221","DOIUrl":"https://doi.org/10.18869/ACADPUB.HMS.22.3.221","url":null,"abstract":"Aims: The exposure to chemical materials and colors affects thyroid gland functions. The aim of this study was to investigate the effects of fume inhalation of oil-based paints on the serum level of thyroid hormones in female and male rats. Materials & Methods: In the experimental study, 15 male and 15 female Wistar rats were studied. The rats were divided into six 5-rat groups including a control group and groups with either 1or 8-hour a day exposure to the paint fumes by gender division. The serum levels of T3, T4, and TSH thyroid hormones were measured after 10 weeks. Data was analyzed by SPSS 20 software using two-way ANOVA and Tukey’s post-hoc. Findings: Mean values of T3 and T4 hormones were significantly reduced in both 1and 8-hour male and female groups than control group (p<0.001). In addition, the more the inhalation time, the more the reduction was. Any reduction in T3 in females in 1-hour (p<0.001) and 8–hour (p<0.05) groups was significantly more than the males. Nevertheless, a significant reduction in T4 was only in 1-hour group (p<0.001). Mean TSH hormone was significantly increased due to the inhalation of paint fume than control group (p<0.001). In addition, such an increase was significant in the female rats in 8-hour group than the male group (p<0.01). Conclusion: The inhalation of oil-based paint fume leads to a reduction in the serum levels of T3 and T4 thyroid hormones, while increases TSH serum level. Such an effect is stronger in the females.","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128449973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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