Pub Date : 2020-09-10DOI: 10.32598/HMS.26.4.3308.2
حامد سارانی, علی نویدیان, ابراهیم ابراهیمی طبس, علی عباسی مندی
{"title":"مقایسه تأثیر مدت زمان و محل تزریق زیرجلدی انوکساپارین بر شدت درد و اندازه کبودی بیماران بستری در بخش مراقبت های قلبی","authors":"حامد سارانی, علی نویدیان, ابراهیم ابراهیمی طبس, علی عباسی مندی","doi":"10.32598/HMS.26.4.3308.2","DOIUrl":"https://doi.org/10.32598/HMS.26.4.3308.2","url":null,"abstract":"","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130890951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.32598/HMS.26.2.3207.1
P. Isfahani, Seydeh Mahboubeh Hossieni Zare, M. Shamsaii
Aims Breast cancer is among the most prevalent cancers in women and has mental and emotional effects, leading to declined quality of life. The current this study aimed to determine the prevalence rate of depression in Iranian women with breast cancer. Methods & Materials This study was conducted using a meta-analysis method at Zabol University of Medical Science in March 2019. Six electronic databases were searched and evaluated for original research papers published on the prevalence of depression in Iranian women with breast cancer. Finally, 15 articles were selected and analysed using Comprehensive Meta-Analysis software. Findings Overall, the prevalence rate of depression in Iranian women with breast cancer was 18.5% (95% CI: 14.2%-23.7%). The highest reported prevalence of depression in Iranian women with breast cancer was 35% in Babol City, in 2013, (95% CI: 27.8%-43%); the lowest prevalence of depression in this population was measured as 3.4% in Qom City, in 2017 (95% CI:1.2%-9%). A significant correlation was observed between the prevalence rate of depression, and sample size, year, and mean age (P<0.05). Conclusion Depression affects approximately one-fifth of women with breast cancer. Therefore, it is essential for the healthcare staff to treat the physical conditions and psychological disorders associated with breast cancer.
{"title":"The Prevalence of Depression in Iranian Women With Breast Cancer: A Meta-Analysis","authors":"P. Isfahani, Seydeh Mahboubeh Hossieni Zare, M. Shamsaii","doi":"10.32598/HMS.26.2.3207.1","DOIUrl":"https://doi.org/10.32598/HMS.26.2.3207.1","url":null,"abstract":"Aims Breast cancer is among the most prevalent cancers in women and has mental and emotional effects, leading to declined quality of life. The current this study aimed to determine the prevalence rate of depression in Iranian women with breast cancer. Methods & Materials This study was conducted using a meta-analysis method at Zabol University of Medical Science in March 2019. Six electronic databases were searched and evaluated for original research papers published on the prevalence of depression in Iranian women with breast cancer. Finally, 15 articles were selected and analysed using Comprehensive Meta-Analysis software. Findings Overall, the prevalence rate of depression in Iranian women with breast cancer was 18.5% (95% CI: 14.2%-23.7%). The highest reported prevalence of depression in Iranian women with breast cancer was 35% in Babol City, in 2013, (95% CI: 27.8%-43%); the lowest prevalence of depression in this population was measured as 3.4% in Qom City, in 2017 (95% CI:1.2%-9%). A significant correlation was observed between the prevalence rate of depression, and sample size, year, and mean age (P<0.05). Conclusion Depression affects approximately one-fifth of women with breast cancer. Therefore, it is essential for the healthcare staff to treat the physical conditions and psychological disorders associated with breast cancer.","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114682205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.32598/HMS.26.2.3161.1
Samanah Aboeepoor, M. Dehghani Ashkezari, F. Aboee-Mehrizi, B. Haghiralsadat, Narges Nikoonahad Lotfabadi
Aims Niosomes have been considered as carriers for targeted delivery of drugs in modern drug delivery systems. The Iranian Nepta (Nepta genus) has unique biological properties; thus, this plant was used in this study to prepare the optimized formulation of niosomes containing extract, and to evaluate its cytotoxicity. Methods & Materials Initially, the extract of Iranian Nepta (N. persica) was prepared. Then, the nano-niosomal system, containing the extract was designed and synthesized using cholesterol and Span-60. The physicochemical properties of the system were evaluated by FTIR and SEM. MTT assay [3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] was used to determine the toxicity of the Nepta extract and nano-system containing it against bone cancer cells (MG63). Findings An optimized formulation was obtained using cholesterol and Span-60 with a ratio of 80:20. The amount of extract release from this formulation continued with a steady slope over a long period of time. The survival rate of MG63 cells against 100 μg/mL of the free form of N. persica extract and its niosomal form were 22% and 8.88%, respectively. Conclusion The present research results suggested that N. persica extract exert anti-cancer effects and niosome could improve its anti-cancer efficiency. Therefore, it could be used as a proper carrier to deliver the extract to the target tissue.
{"title":"Designing and Characterizing Nano-carriers Containing Nepeta Persica Extract and Their Effect on Bone Cancer","authors":"Samanah Aboeepoor, M. Dehghani Ashkezari, F. Aboee-Mehrizi, B. Haghiralsadat, Narges Nikoonahad Lotfabadi","doi":"10.32598/HMS.26.2.3161.1","DOIUrl":"https://doi.org/10.32598/HMS.26.2.3161.1","url":null,"abstract":"Aims Niosomes have been considered as carriers for targeted delivery of drugs in modern drug delivery systems. The Iranian Nepta (Nepta genus) has unique biological properties; thus, this plant was used in this study to prepare the optimized formulation of niosomes containing extract, and to evaluate its cytotoxicity. Methods & Materials Initially, the extract of Iranian Nepta (N. persica) was prepared. Then, the nano-niosomal system, containing the extract was designed and synthesized using cholesterol and Span-60. The physicochemical properties of the system were evaluated by FTIR and SEM. MTT assay [3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] was used to determine the toxicity of the Nepta extract and nano-system containing it against bone cancer cells (MG63). Findings An optimized formulation was obtained using cholesterol and Span-60 with a ratio of 80:20. The amount of extract release from this formulation continued with a steady slope over a long period of time. The survival rate of MG63 cells against 100 μg/mL of the free form of N. persica extract and its niosomal form were 22% and 8.88%, respectively. Conclusion The present research results suggested that N. persica extract exert anti-cancer effects and niosome could improve its anti-cancer efficiency. Therefore, it could be used as a proper carrier to deliver the extract to the target tissue.","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129997594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.32598/HMS.26.2.3190.1
A. Saremi, M. Parastesh, L. Mohammadi
Aims Resistin is secreted by adipose tissue and could be the link between diabetes and infertility. This study aimed to investigate the alteration of resistin following aerobic exercise training in diabetic rats and its possible interaction with sperm parameters. Methods & Materials In this experimental study, 30 male Wistar rats (age: 56 days, weight: 200-250g) were randomly divided equally into three groups of healthy control, diabetic control, and diabetic aerobic exercises. Diabetes was induced with a unique intraperitoneal injection (65 mg/kg body weight) of streptozotocin. Seven days after the injection and after 12 hours of fasting, the animals with blood glucose levels of ≥250 mg/dL were considered diabetic. Seven days after the induction of diabetes, the animals in the exercise group were subjected to progressive aerobic training (treadmill running for 1 h, 27 m/min, 5 d/wk). After 10 weeks of exercise, the sperm quality and resistin concentrations were measured. The obtained data were compared using Analysis of Variance (ANOVA) (P<0.05). Findings The induction of diabetes significantly decreased sperm count (P=0.001), motility (P=0.001), viability (P=0.001), and morphology (P=0.01). The sperm parameters, such as count (P=0.03) and viability (P=0.002) were significantly higher in the diabetic exercise group, compared to the diabetic sedentary group. No significant changes were found in resistin levels between diabetic exercise and diabetic sedentary groups (P=0.40). Conclusion The collected results indicated that the 10-week aerobic training regimen improved sperm quality, independent of changes in resistin levels, in type 2 diabetes mellitus rat models.
{"title":"Resistin Changes Following Aerobic Exercise and its Relationship With Fertility in Male Rats With Type 2 Diabetes","authors":"A. Saremi, M. Parastesh, L. Mohammadi","doi":"10.32598/HMS.26.2.3190.1","DOIUrl":"https://doi.org/10.32598/HMS.26.2.3190.1","url":null,"abstract":"Aims Resistin is secreted by adipose tissue and could be the link between diabetes and infertility. This study aimed to investigate the alteration of resistin following aerobic exercise training in diabetic rats and its possible interaction with sperm parameters. Methods & Materials In this experimental study, 30 male Wistar rats (age: 56 days, weight: 200-250g) were randomly divided equally into three groups of healthy control, diabetic control, and diabetic aerobic exercises. Diabetes was induced with a unique intraperitoneal injection (65 mg/kg body weight) of streptozotocin. Seven days after the injection and after 12 hours of fasting, the animals with blood glucose levels of ≥250 mg/dL were considered diabetic. Seven days after the induction of diabetes, the animals in the exercise group were subjected to progressive aerobic training (treadmill running for 1 h, 27 m/min, 5 d/wk). After 10 weeks of exercise, the sperm quality and resistin concentrations were measured. The obtained data were compared using Analysis of Variance (ANOVA) (P<0.05). Findings The induction of diabetes significantly decreased sperm count (P=0.001), motility (P=0.001), viability (P=0.001), and morphology (P=0.01). The sperm parameters, such as count (P=0.03) and viability (P=0.002) were significantly higher in the diabetic exercise group, compared to the diabetic sedentary group. No significant changes were found in resistin levels between diabetic exercise and diabetic sedentary groups (P=0.40). Conclusion The collected results indicated that the 10-week aerobic training regimen improved sperm quality, independent of changes in resistin levels, in type 2 diabetes mellitus rat models.","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127556015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.32598/HMS.26.2.3169.1
A. Amouzeshi, Mahmoud Ganji Fard, N. Azdaki
Aims Tuberculous pericarditis is present in only one to two percent of the tuberculosis cases, i.e. considered rare. The disease is responsible for 4% and 7% of acute pericarditis and cardiac tamponade cases, respectively. Moreover, these conditions are associated with hazardous side effects. Thus, timely and precise diagnosis of the disease could prevent such complications. Case report We reported an 85-year-old male case who was referred with clinical signs of breath shortness, cardiac murmur, and swollen jugular veins. Besides, the relevant laboratory findings indicated elevated white blood cell counts (11.6). In addition, other diagnostic measures, such as thoracic radiography and echocardiography were performed on the patient. Then, the diagnosis indicated a 28mm diameter of pericardial fluid; accordingly, the patient was selected as a candidate for emergency pericardiotomy. The fluid was drained, and therapeutic medication, as well as antibiotics were administered for the patient. Finally, the patient was discharged with an appropriate general condition. Conclusion A sample of pericardial fluid was tested using polymerase chain reaction)method for the diagnosis of tuberculosis, which provided a positive result. Considering the dangerous complications of this disease, it is recommended for all patients who could suction severe pericardial effusion to be tested for this disease.
{"title":"Tuberculous Pericarditis Causing Severe Pericardial Effusion: A Case Study","authors":"A. Amouzeshi, Mahmoud Ganji Fard, N. Azdaki","doi":"10.32598/HMS.26.2.3169.1","DOIUrl":"https://doi.org/10.32598/HMS.26.2.3169.1","url":null,"abstract":"Aims Tuberculous pericarditis is present in only one to two percent of the tuberculosis cases, i.e. considered rare. The disease is responsible for 4% and 7% of acute pericarditis and cardiac tamponade cases, respectively. Moreover, these conditions are associated with hazardous side effects. Thus, timely and precise diagnosis of the disease could prevent such complications. Case report We reported an 85-year-old male case who was referred with clinical signs of breath shortness, cardiac murmur, and swollen jugular veins. Besides, the relevant laboratory findings indicated elevated white blood cell counts (11.6). In addition, other diagnostic measures, such as thoracic radiography and echocardiography were performed on the patient. Then, the diagnosis indicated a 28mm diameter of pericardial fluid; accordingly, the patient was selected as a candidate for emergency pericardiotomy. The fluid was drained, and therapeutic medication, as well as antibiotics were administered for the patient. Finally, the patient was discharged with an appropriate general condition. Conclusion A sample of pericardial fluid was tested using polymerase chain reaction)method for the diagnosis of tuberculosis, which provided a positive result. Considering the dangerous complications of this disease, it is recommended for all patients who could suction severe pericardial effusion to be tested for this disease.","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121332472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"متغیرهای تعیینکننده کیفیت زندگی مرتبط با سلامت در افراد مبتلا به اچآیوی","authors":"سعید قدرتی, دنیا رضایی, نیوشا وزیری, بهاره شکرانی, غزاله سادات احسانی حضراتیفرد","doi":"10.32598/HMS.26.2.3012.1","DOIUrl":"https://doi.org/10.32598/HMS.26.2.3012.1","url":null,"abstract":"","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"2010 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114880002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.32598/HMS.26.2.2008.1
Sepehr Lotfi Marangaloo, Amir Shahriar Ariamanesh, Behzad Aminzadeh, H. Abedi, A. Montazerabadi
Aims This study compared relative contrast values in three-dimensional Double Echo Steady State (DESS) sequences with two flip angles of 40 and 90 degrees and other routine sequences. The obtained data could help to prove the effects of this sequence, compared to the other routine sequences; accordingly, it could be applied for better detection of lesions resulting from cartilage abnormalities. Methods & Materials Total, 15 patients, including 9 men (14-56 y) and 6 women (36-65 y) with knee pain symptoms were referred to us by an orthopedic physician. All of the investigated patients underwent Magnetic Resonance Imaging (MRI) using DESS sequences with two flip angles of 40 and 90 degrees, as well as STIR , PD, T2, and 3D FLASH. We analyzed the acquired images using the Radiant DICOM Viewer4.6.9 software. We calculated relative contrast values for the selected SAGITAL images per sequence for each patient. The obtained data were analyzed using SPSS. Findings Friedman and Wilcoxon statistical tests data revealed significant P values (<0.05) for all the sequences examined in this study. The DESS sequence with a flip angle of 90° presented the most relative contrast value with the average score of 77.2667. The FLASH sequence provided the worst result of 3.733 for the relative contrast value. Conclusion The DESS sequence with 90° flip angle indicated the best relative contrast values and provided the best possible signal from the synovial fluid and the cartilage; therefore, it leads to the better examination of articular cartilage in terms of lesion. Accordingly, the DESS sequence with a flip angle of 90° was the optimal sequence to evaluate cartilage abnormalities among the examined sequences in this study.
{"title":"Comparing Relative Contrast in Three-dimensional Double-echo Steady State With Routine Sequences for a Better Diagnosis of Knee Cartilage Anomalies","authors":"Sepehr Lotfi Marangaloo, Amir Shahriar Ariamanesh, Behzad Aminzadeh, H. Abedi, A. Montazerabadi","doi":"10.32598/HMS.26.2.2008.1","DOIUrl":"https://doi.org/10.32598/HMS.26.2.2008.1","url":null,"abstract":"Aims This study compared relative contrast values in three-dimensional Double Echo Steady State (DESS) sequences with two flip angles of 40 and 90 degrees and other routine sequences. The obtained data could help to prove the effects of this sequence, compared to the other routine sequences; accordingly, it could be applied for better detection of lesions resulting from cartilage abnormalities. Methods & Materials Total, 15 patients, including 9 men (14-56 y) and 6 women (36-65 y) with knee pain symptoms were referred to us by an orthopedic physician. All of the investigated patients underwent Magnetic Resonance Imaging (MRI) using DESS sequences with two flip angles of 40 and 90 degrees, as well as STIR , PD, T2, and 3D FLASH. We analyzed the acquired images using the Radiant DICOM Viewer4.6.9 software. We calculated relative contrast values for the selected SAGITAL images per sequence for each patient. The obtained data were analyzed using SPSS. Findings Friedman and Wilcoxon statistical tests data revealed significant P values (<0.05) for all the sequences examined in this study. The DESS sequence with a flip angle of 90° presented the most relative contrast value with the average score of 77.2667. The FLASH sequence provided the worst result of 3.733 for the relative contrast value. Conclusion The DESS sequence with 90° flip angle indicated the best relative contrast values and provided the best possible signal from the synovial fluid and the cartilage; therefore, it leads to the better examination of articular cartilage in terms of lesion. Accordingly, the DESS sequence with a flip angle of 90° was the optimal sequence to evaluate cartilage abnormalities among the examined sequences in this study.","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122299307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-10DOI: 10.32598/HMS.26.1.3145.1
A. Salehi, Hajar Abbaszadeh, P. Farzanegi
Aims: Type 2 diabetes is the result of complex interactions between genetic and environmental factors that affect fat and glucose metabolism. The purpose of this study was to determine the effect of periodic exercise and resveratrol supplement on the expression levels of Pparg Coactivator 1-Alpha (PGC-1α) and Pyruvate Dehydrogenase Kinase (PDK4) genes in gastrocnemius muscle of old rates with type 2 diabetes. Methods & Materials: 42 male rats (mean age= 40-50 weeks; mean body weight= 250-300 g) were randomly divided into 6 groups: healthy-control, diabetic-control, Diabetic+Periodic Exercise, Diabetic+Supplement, Diabetic+Periodic Exercise+Supplement and Saline. The type 2 diabetes was induced by intraperitoneal injection of Streptozotocin (50 mg/kg body weight). The exercise protocol consisted of 10 sets of 1-min activities at 50% intensity and a 2-min rest period between sets, and each week the speed was increased by 2 meters per minute. The exercises were performed for eight weeks. Resveratrol supplement was injected intraperitoneally daily at a dose of 20 mg/kg body weight. The expressions of PDK4 and PGC-1α in the gastrocnemius muscle were measured by real time Polymerase Chain Reaction (PCR) method. Findings: highest expression level of PDK4 and PGC-1α genes in gastrocnemius muscle was observed in the diabetic group received both periodic exercise and Resveratrol supplement and the lowest level was reported in the diabetic-control and saline groups. Conclusion The combination of resveratrol supplementation and periodic exercise can have beneficial effects on PDK4 and PGC-1α expression levels in the gastrocnemius muscle of old rats with type 2 diabetes and reduce the risks of diabetes-related complications.
{"title":"The Effect of Periodic Exercise and Resveratrol Supplementation on the Expression of Pparg Coactivator-1 Alpha and Pyruvate Dehydrogenase Kinase Genes in Gastrocnemius Muscle of Old Rats With Type 2 Diabetes","authors":"A. Salehi, Hajar Abbaszadeh, P. Farzanegi","doi":"10.32598/HMS.26.1.3145.1","DOIUrl":"https://doi.org/10.32598/HMS.26.1.3145.1","url":null,"abstract":"Aims: Type 2 diabetes is the result of complex interactions between genetic and environmental factors that affect fat and glucose metabolism. The purpose of this study was to determine the effect of periodic exercise and resveratrol supplement on the expression levels of Pparg Coactivator 1-Alpha (PGC-1α) and Pyruvate Dehydrogenase Kinase (PDK4) genes in gastrocnemius muscle of old rates with type 2 diabetes. Methods & Materials: 42 male rats (mean age= 40-50 weeks; mean body weight= 250-300 g) were randomly divided into 6 groups: healthy-control, diabetic-control, Diabetic+Periodic Exercise, Diabetic+Supplement, Diabetic+Periodic Exercise+Supplement and Saline. The type 2 diabetes was induced by intraperitoneal injection of Streptozotocin (50 mg/kg body weight). The exercise protocol consisted of 10 sets of 1-min activities at 50% intensity and a 2-min rest period between sets, and each week the speed was increased by 2 meters per minute. The exercises were performed for eight weeks. Resveratrol supplement was injected intraperitoneally daily at a dose of 20 mg/kg body weight. The expressions of PDK4 and PGC-1α in the gastrocnemius muscle were measured by real time Polymerase Chain Reaction (PCR) method. Findings: highest expression level of PDK4 and PGC-1α genes in gastrocnemius muscle was observed in the diabetic group received both periodic exercise and Resveratrol supplement and the lowest level was reported in the diabetic-control and saline groups. Conclusion The combination of resveratrol supplementation and periodic exercise can have beneficial effects on PDK4 and PGC-1α expression levels in the gastrocnemius muscle of old rats with type 2 diabetes and reduce the risks of diabetes-related complications.","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127164231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-10DOI: 10.32598/HMS.26.1.3116.1
Mohammad Mehdi Padam, A. Khoshvaghti
Aims: Damage to liver tissue and its dysfunction is very important and if left untreated, it can cause serious problems and even death. In this study, we aimed to investigate the effects of the hydroalcoholic extracts of Linum usitatissimum and Rosa damascena on liver enzymes, total protein, bilirubin, albumin, and serum glucose levels. Materials and Methods: This is a non-randomized clinical trial conducted on 42 male rats divided into 6 groups; control group (group 1) received only sufficient water and food, groups 1 and 2 received 300 and 500 mg/ kgB.W Linum usitatissimum extract, groups 3 and 4 received 500 and 1000 mg/ kgB.W Rosa damascena, and group 6 received 100 mg/ kgB.W Linum usitatissimum plus 250 mg/ kgB.W Rosa damascena extracts intraperitoneally for 28 days. After the last injection, the rats were weighed and their blood samples were collected. The study parameters were measured using a colorimetric method by a spectrophotometer, and then were analyzed using ANOVA and Tukey’s test in SPSS V. 25 at a significance level of P<0.05. Findings: There was no significant difference between alanine aminotransferase, alkaline phosphatase, total and direct bilirubin levels in the control group in comparison with other groups (P>0.05). In the groups received Rosa damascena extract, there was a significant difference between total protein and albumin levels compared to the control group (P<0.05). Moreover, there was a significant difference between serum glucose and aspartate aminotransferase in the control group compared to other groups (P<0.05). Conclusion: Linum usitatissimum and Rosa damascena have no negative effect on the liver function. The probability of diarrhea occurrence and the possible effects on the total protein and serum albumin after using Rosa damascena, and the effects of different doses of Linum usitatissimum on the glucose levels should be taken into account.
{"title":"A Comparative Study on the Effects of Using Hydroalcoholic Extracts of Linum Usitatissimum and Rosa Damascena on Liver Function in Adult Male Rats","authors":"Mohammad Mehdi Padam, A. Khoshvaghti","doi":"10.32598/HMS.26.1.3116.1","DOIUrl":"https://doi.org/10.32598/HMS.26.1.3116.1","url":null,"abstract":"Aims: Damage to liver tissue and its dysfunction is very important and if left untreated, it can cause serious problems and even death. In this study, we aimed to investigate the effects of the hydroalcoholic extracts of Linum usitatissimum and Rosa damascena on liver enzymes, total protein, bilirubin, albumin, and serum glucose levels. Materials and Methods: This is a non-randomized clinical trial conducted on 42 male rats divided into 6 groups; control group (group 1) received only sufficient water and food, groups 1 and 2 received 300 and 500 mg/ kgB.W Linum usitatissimum extract, groups 3 and 4 received 500 and 1000 mg/ kgB.W Rosa damascena, and group 6 received 100 mg/ kgB.W Linum usitatissimum plus 250 mg/ kgB.W Rosa damascena extracts intraperitoneally for 28 days. After the last injection, the rats were weighed and their blood samples were collected. The study parameters were measured using a colorimetric method by a spectrophotometer, and then were analyzed using ANOVA and Tukey’s test in SPSS V. 25 at a significance level of P<0.05. Findings: There was no significant difference between alanine aminotransferase, alkaline phosphatase, total and direct bilirubin levels in the control group in comparison with other groups (P>0.05). In the groups received Rosa damascena extract, there was a significant difference between total protein and albumin levels compared to the control group (P<0.05). Moreover, there was a significant difference between serum glucose and aspartate aminotransferase in the control group compared to other groups (P<0.05). Conclusion: Linum usitatissimum and Rosa damascena have no negative effect on the liver function. The probability of diarrhea occurrence and the possible effects on the total protein and serum albumin after using Rosa damascena, and the effects of different doses of Linum usitatissimum on the glucose levels should be taken into account.","PeriodicalId":300087,"journal":{"name":"The Horizon of Medical Sciences","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127770228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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