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Science Communication: An essential skill for clinicians 科学传播:临床医生的基本技能
Pub Date : 2021-08-01 DOI: 10.32593/jstmu/vol4.iss1.134
M. Babar, Mohammad H. Abutaleb
While growing up in the digital age, most of us had the opportunity to witness the development of advanced methods and means of communication. We can fondly remember shifting from searching months’ old manuscripts in the libraries to using a smartphone to easily access the latest science in the palm of our hands. This development has not been confined to the scientific manuscripts only. Internet and social media platforms gave an opportunity to any individual interested in any field to develop ideas and share them with a wider audience. This freedom, coupled with the trend of covering medico-scientific news in the electronic and print media has made the general public more concerned about their physical and mental health. However, unfortunately, these developments have not all been very fruitful. In a real world setting where opinions are stronger than the truth, opportunists managed to exploit it to publicize their sociopolitical agenda.1 Advertisement of quackery, opposition of vaccination drives and defaming of safe surgical procedures have risen to prominence over the recent decades.2 These individuals and organized groups generally back their claims with unregulated blogs and fake news websites for spreading pseudoscience.
在数字时代成长的过程中,我们大多数人都有机会见证先进通信方法和手段的发展。我们可以深情地记得,从在图书馆里搜索几个月前的手稿,到用智能手机轻松获取掌上最新科学成果的转变。这种发展并不仅仅局限于科学手稿。互联网和社交媒体平台为任何对任何领域感兴趣的个人提供了发展想法并与更广泛的受众分享的机会。这种自由,加上在电子和印刷媒体上报道医学科学新闻的趋势,使公众更加关心他们的身心健康。然而,不幸的是,这些发展并不都是卓有成效的。在一个观点比真相更强大的现实世界中,机会主义者设法利用它来宣传他们的社会政治议程近几十年来,庸医广告、反对接种疫苗运动和诋毁安全手术程序的现象日益突出这些个人和有组织的团体通常通过不受监管的博客和假新闻网站来传播伪科学。
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引用次数: 0
Ischemic stroke is a rare finding in COVID-19 infected patients: A case report 缺血性卒中是COVID-19感染患者中一种罕见的发现:1例报告
Pub Date : 2021-08-01 DOI: 10.32593/jstmu/vol4.iss1.119
Anum Ashfaq, Muhammad Atif Beg, Irshad Khan, T. Hussain, Uzma Batool
Coronavirus has become a global pandemic and causing huge number of mortalities due to variety of complications. Presentations from COVID-19 infection vary from mild respiratory symptoms, fever, pulmonary embolism, heart attacks and neurological manifestations to deadly acute respiratory distress syndrome. A case of elderly patient who was diagnosed as having COVID-19 infection with mild symptoms who was then admitted in hospital for the treatment of COVID-19 infection and then developed a massive ischemic stroke during the hospital stay. Coronavirus disease can present with atypical features for which clinicians should be aware of; so that the diagnosis and treatment should not be delayed and patient can receive maximum benefit with special emphasis on anticoagulant therapy in minimal symptomatic infection.
冠状病毒已成为全球大流行,并因各种并发症导致大量死亡。COVID-19感染的症状各不相同,从轻微的呼吸道症状、发烧、肺栓塞、心脏病发作和神经系统症状到致命的急性呼吸窘迫综合征。1例老年患者被诊断为新冠肺炎感染,症状轻微,入院治疗新冠肺炎感染,住院期间发生大面积缺血性中风。冠状病毒病可能呈现非典型特征,临床医生应注意这些特征;因此,不应延误诊断和治疗,并在最小的症状性感染中特别强调抗凝治疗,使患者获得最大的益处。
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引用次数: 0
Emerging role of chondroitin sulfate based nanocarriers in improving the therapeutic outcome of NSAIDs in the treatment of osteoarthritis through the TDDDS 基于硫酸软骨素的纳米载体通过TDDDS改善非甾体抗炎药治疗骨关节炎的疗效
Pub Date : 2021-08-01 DOI: 10.32593/jstmu/vol4.iss1.133
Rabia Gul, Faryal Jahan, Faiza Naseer
Osteoarthritis is characterized by joint destruction followed by severe inflammation caused by variety of proinflammatory mediators released due to upregulation of nuclear translocation of nuclear factor (NF-kB). Current treatment involves chronic administration of non-steroidal anti-inflammatory drugs (NSAIDs) that is associated with bewildering array of systemic adverse effects. Transdermal drug delivery system address challenges of systemic toxicities but toxic chemical penetration enhancers limit its utility.  Novel drug delivery system explores the potential of bio-inspired materials for designing of safe and effective carriers that specifically deliver drug to site of action with enhanced transdermal penetration of the drug. Chondroitin sulfate, a biopolymer that mimic extracellular matrix, binds specifically with its overexpressed receptors (CD44, RHAMM and ICAM-I) at inflammatory site, biodegradable and possess intrinsic anti-inflammatory properties. These attributes render chondroitin sulfate an ideal carrier for the drug delivery in osteoarthritis. Chondroitin sulfate based nanocarriers serve as a potential drug delivery system that not only deliver anti-arthritis drug through the skin but also produce synergistic effect to improve therapeutic outcome. In this review, molecular mechanism of intrinsic anti-inflammatory effects of chondroitin sulfate in osteoarthritis is discussed in detail. Moreover, potential of chondroitin sulfate to perform dual role of therapeutic agent as well as serve as nanocarrier in transdermal drug delivery for the treatment of osteoarthritis is elaborated. 
骨关节炎的特点是由于核因子核易位(NF-kB)的上调而释放多种促炎介质,导致关节破坏并伴有严重炎症。目前的治疗包括慢性服用非甾体抗炎药(NSAIDs),这与一系列令人眼花缭乱的全身不良反应有关。经皮给药系统解决了全身毒性的挑战,但有毒化学渗透增强剂限制了其应用。新型药物传递系统探索了生物启发材料的潜力,用于设计安全有效的载体,专门将药物传递到作用部位,增强药物的透皮渗透。硫酸软骨素是一种模拟细胞外基质的生物聚合物,在炎症部位特异性地与其过表达受体(CD44, RHAMM和ICAM-I)结合,可生物降解并具有固有的抗炎特性。这些特性使硫酸软骨素成为骨关节炎药物递送的理想载体。硫酸软骨素纳米载体作为一种潜在的药物传递系统,不仅可以通过皮肤传递抗关节炎药物,还可以产生协同效应,提高治疗效果。本文就硫酸软骨素在骨关节炎中的内在抗炎作用的分子机制作一综述。此外,还阐述了硫酸软骨素在骨关节炎的经皮给药中作为治疗药物的双重作用以及作为纳米载体的潜力。
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引用次数: 0
Impact of breast cancer awareness health campaigns on knowledge of female educationalists of Islamabad and Rawalpindi; an interventional study 乳腺癌认识健康运动对伊斯兰堡和拉瓦尔品第女性教育工作者知识的影响;一项介入研究
Pub Date : 2021-08-01 DOI: 10.32593/jstmu/vol4.iss1.132
Z. Naeem, Mahrukh Nadeem, M. Kamil, Aiman Ayub, Kalsoom Nawaz, S. Karim, A. Hassan
Introduction: Breast carcinoma is the leading cause of cancer in women worldwide. WHO statistics show 1.2 million new cases every year. Pakistan reports nearly 40,000 lives from Breast Cancer annually. Objective: To evaluate existing awareness levels regarding breast cancer among female educationalists in twin cities and to counsel the participants about diagnostic tools such as mammographic-screening and breast self-examination Methodology: The study design was an interventional community trial and was conducted on female teachers aged 30-60 years. Data was collected by a questionnaire, given before and after the interactive session to evaluate its impacts. SPSS Version 23 was used for data entry analysis. Descriptive statistics were used to calculate the quantitative and qualitative variables. McNemar’s test was applied for this. P values less than 0.05 were considered significant. Results: Total number of participants was 106 women with a median age of 43.3 years (range of age 31-54 years). Before intervening, 67 (63.2%) participants had no knowledge of mammographic-screening and 15 (14.2%) participants didn’t know the definitive way of diagnosing it. 2 After intervention, mammogram was selected to be the definitive way of diagnosing breast cancer by 91 (85.8%) participants. 91(85.8%) participants would encourage close family and friends to get screened. 104 (98.1%) of women had become familiar with technique of self-examination, as compared to 63 (59.4%) before. Conclusion: Misconceptions about risk factors, screening methods and diagnostic procedures were identified and elucidated. This encouraged participants to start performing regular self-exams and get mammograms.
导读:乳腺癌是世界范围内女性癌症的主要原因。世卫组织的统计数据显示,每年有120万新病例。巴基斯坦每年报告近4万人死于乳腺癌。目的:评估双城女性教育工作者对乳腺癌的现有认知水平,并向参与者提供乳腺x光检查和乳房自检等诊断工具的建议。研究设计为干预性社区试验,研究对象为30-60岁的女教师。数据是通过问卷收集的,在互动式会议前后发放,以评估其影响。使用SPSS Version 23进行数据录入分析。采用描述性统计方法计算定量和定性变量。McNemar的测试被应用于此。P值小于0.05为显著性。结果:参与者总数为106名女性,中位年龄为43.3岁(范围为31-54岁)。干预前,67名(63.2%)参与者不了解乳房x光检查,15名(14.2%)参与者不知道诊断乳房x光检查的确切方法。2干预后,91名(85.8%)参与者选择乳房x光检查作为诊断乳腺癌的最终方法。91名(85.8%)受访者会鼓励亲密的家人和朋友接受筛查。有104名妇女(98.1%)已熟悉自查技术,而以前有63名妇女(59.4%)已熟悉自查技术。结论:发现并阐明了对危险因素、筛查方法和诊断程序的误解。这鼓励参与者开始定期进行自我检查并进行乳房x光检查。
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引用次数: 0
Diagnostic accuracy of ultrasound in detection of pregnancy associated breast cancer 超声检测妊娠相关乳腺癌的诊断准确性
Pub Date : 2021-08-01 DOI: 10.32593/jstmu/vol4.iss1.113
Zainab Mehmood, R. Shahzad, Ismat Fatima, Abubaker Shahid
Introduction: Some unique physiological changes occur in breast volume and water content during pregnancy which makes the radiological evaluation of the breast difficult.  As a result, diagnosis of Pregnancy Associated Breast Cancer.  is often delayed. Objective: To find out the diagnostic accuracy of ultrasonography in detection of pregnancy associated breast cancer taking histopathology as gold standard. Methodology: Present Cross-sectional study was carried out at INMOL Hospital, Lahore. Ultrasound of 200 women was performed. The patient was laid supine and then turned slightly in oblique position to scan the breast with high frequency linear probe (7.5-10 MHz). The contra-lateral breast and both axillae were also scanned in the same way. Findings were categorized on the basis of Breast Imaging Reporting and Data System (BI-RADS) assessment categories. Subsequently the breast tissue was sent to histopathology laboratory for tissue diagnosis. The pathologist was blinded of the results of ultrasonography. Results: Mean age was 34 ± 11.36 years. Twenty-eight percent patients were primi-para while 72% patients were multi-para. Diagnostic accuracy of ultrasonography taking histopathology as gold standard was analyzed and ultrasonography had sensitivity 84.78%, specificity 98.05%, positive predictive value 92.85%, negative predictive value 95.56% and diagnostic accuracy was 95%. Invasive ductal carcinoma was most commonly observed (P<0.001) malignant histopathology. On the other hand, significantly high (P = 0.033) number of benign lesions were Fibroadenomas. Conclusion: The high sensitivity and specificity along with easy availability, and non-invasive nature makes ultrasonography a very useful technique for the diagnosis of Pregnancy Associated Breast Cancer.
导读:怀孕期间乳房体积和含水量发生了一些独特的生理变化,这使得乳房的放射学评估变得困难。因此,妊娠相关乳腺癌的诊断。经常被耽搁。目的:探讨以组织病理学为金标准的超声检查对妊娠相关乳腺癌的诊断准确性。方法:本横断面研究在拉合尔INMOL医院进行。对200名妇女进行超声检查。患者仰卧,稍斜位,用高频线性探头(7.5-10 MHz)扫描乳房。对侧乳房和双腋窝也用同样的方法扫描。根据乳腺成像报告和数据系统(BI-RADS)评估类别对结果进行分类。随后将乳腺组织送组织病理学实验室进行组织诊断。病理学家不知道超声检查的结果。结果:平均年龄34±11.36岁。28%的患者为初产妇,72%的患者为多产妇。分析以组织病理学为金标准的超声诊断准确率,超声灵敏度为84.78%,特异性为98.05%,阳性预测值为92.85%,阴性预测值为95.56%,诊断准确率为95%。浸润性导管癌是最常见的恶性组织病理学(P<0.001)。另一方面,纤维腺瘤的良性病变数量显著增加(P = 0.033)。结论:超声检查具有灵敏度高、特异性强、易获得、无创等优点,是诊断妊娠相关乳腺癌的重要技术手段。
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引用次数: 0
Impact of online learning; experiences and attitudes of faculty and students from two medical colleges 网络学习的影响;两所医学院师生的经验与态度
Pub Date : 2020-12-23 DOI: 10.32593/JSTMU/VOL3.ISS2.107
Safina Ahmed, M. Niaz, Zara Seemab, Rifat Nadeem
Introduction: In this changing paradigm of flipped classrooms, online learning is becoming center of focus. The spread of CoVID-19 pandemic has prompted medical institutions to quickly adopt online curriculum delivery to avoid any breaks. This transition seems to adequately serve the needs of medical education. As this new technology is rapidly being implemented, the students’ and teachers’ perspectives need to be evaluated to assess the outcome of these changes and to design effective strategies. Objectives: To assess the impact of online learning by recording experiences and attitudes of faculty members and students from two medical institutions. Materials & Methods: The study was conducted at SCM and FUMC, Islamabad. 275 3rd year MBBS students from both medical colleges along with 40 faculty members were enrolled after taking consent. Their perspectives were taken by a questionnaire. They were asked about familiarity of e-learning, its advantages, disadvantages, credibility of online assessments and whether e-learning should be part of future medical education. The data was analyzed using SPSS23. Results: 34 faculty members and 214 students from both institutes completed the questionnaire. Majority of the faculty members and students believed that e-learning can only serve as complementary role to traditional teaching. Conclusion: E-learning provided us the needed mode to continue delivering the course in the need of the hour. Both faculty and students deemed that online learning is not as proficient as face-to-face teaching however, hybrid model combining both modalities can achieve better results.
简介:在翻转课堂不断变化的范式中,在线学习正成为人们关注的焦点。新冠肺炎疫情的蔓延促使医疗机构迅速采用在线课程交付,以避免任何中断。这种转变似乎充分满足了医学教育的需要。随着这项新技术的迅速实施,需要评估学生和教师的观点,以评估这些变化的结果,并设计有效的策略。目的:通过记录来自两家医疗机构的教师和学生的经验和态度来评估在线学习的影响。材料与方法:研究在伊斯兰堡的SCM和FUMC进行,来自两所医学院的275名三年级MBBS学生和40名教师在征得同意后被纳入研究。他们的观点是通过问卷调查得出的。他们被问及对电子学习的熟悉程度、其优点、缺点、在线评估的可信度以及电子学习是否应成为未来医学教育的一部分。数据采用SPSS23进行分析。结果:两所学院共34名教师和214名学生完成问卷调查。大多数教师和学生认为网络学习只能作为传统教学的补充。结论:E-learning为我们提供了一种必要的模式,可以在需要的时间内继续提供课程。教师和学生都认为在线学习不如面对面教学熟练,但将两者结合起来的混合模式可以取得更好的效果。
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引用次数: 0
Myths and misconceptions related to CoVID-19 among future health care providers in a private University of Islamabad - An interventional study 伊斯兰堡私立大学未来医疗服务提供者中与CoVID-19相关的神话和误解——一项介入性研究
Pub Date : 2020-12-23 DOI: 10.32593/JSTMU/VOL3.ISS2.105
S. Naseem, Z. Naeem, H. Choudhry, Ghanwa Bereach, S. Rafi, Fozia Tahir, M. Qazi, Sana Mangrio, R. Khalil
Background: Erroneous treatments are hovering all over the internet and social media due to non-existence of the ultimate treatment to CoVID-19. There is a need to disseminate correct knowledge and encourage practices based on evidence, which can successfully prevent the spread of this deadly global pandemic. Objectives: The objective of the study was to explore the myths and misconceptions related to CoVID-19 pandemic in a pre and post health awareness workshop among the future health care professionals in a private medical university in Islamabad, Pakistan. Methodology: A quasi experimental study was carried out in March, 2020 over a period of two weeks at Shifa Tameer-e-Millat University, Islamabad. The participants included undergraduate medical, nursing and pharmaceutical sciences students, making a total sample size of 315. Simple random sampling was used. Data was collected using a self-designed questionnaire exploring the myths and misconceptions. A pre and post health awareness workshop was conducted and questionnaires filled by the participants. Data was analyzed using SPSS 23. Result: A change in the frequency of concepts related to myths and misconceptions was observed following the health awareness session, results were statistically significant using McNemar’s test in context to majority of the myths and misconceptions, p-value < 0.05. Conclusion:  Health education has very important role in public health especially in times when the health problem is novel. In such situations, emphasis should be paid on the health education as it can modify the behavior regarding myths and misconceptions which can contribute to decrease in morbidity and mortality.
背景:由于没有最终的治疗方法,网络和社交媒体上充斥着错误的治疗方法。有必要传播正确的知识,鼓励以证据为基础的做法,这样才能成功地防止这一致命的全球流行病的蔓延。目的:本研究的目的是在巴基斯坦伊斯兰堡一所私立医科大学的未来卫生保健专业人员的健康意识研讨会上探讨与CoVID-19大流行相关的神话和误解。方法:2020年3月,在伊斯兰堡的Shifa Tameer-e-Millat大学进行了为期两周的准实验研究。参与者包括医学、护理和药学专业的本科生,总样本量为315人。采用简单随机抽样。数据是通过自行设计的调查问卷收集的,以探索迷思和误解。举办了前后健康意识讲习班,参与者填写了问卷。数据采用SPSS 23进行分析。结果:健康意识课程结束后,与神话和误解相关的概念频率发生了变化,使用McNemar 's检验对大多数神话和误解进行了背景检验,结果具有统计学意义,p值< 0.05。结论:健康教育在公共卫生中具有重要的作用,特别是在健康问题比较新时期。在这种情况下,应重视健康教育,因为它可以改变对神话和误解的行为,从而有助于降低发病率和死亡率。
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引用次数: 0
Faculty development program: Way to excellence 教师发展计划:通往卓越之路
Pub Date : 2020-12-23 DOI: 10.32593/JSTMU/VOL3.ISS2.109
Riffat Shafi, A. Rauf, Khurram Irshad, Iffat F. Zaman, A. Hussain, Syed Shoaib Shah, Mohammed Amir
Introduction: The importance of faculty development programs (FDP) to improve teaching effectiveness has been emphasized in recent years. Our endeavors to improve teaching ways at Shifa College of Medicine, include development of student feedback mechanisms, professional development programs, and research into teaching. New trends taking place in academic medicine were accommodated by modification of faculty development model. Methods: With an aim to assess the perceptions of faculty about FDP at Shifa College of Medicine we gathered views of faculty, by administering questionnaire, conducting focus group and individual interviews. Results: More than half of faculty (51%-83%) agreed with various items related to teaching and learning concepts, 79% believed that they learned assessment methods. 73% agreed that it was a source of introduction to new educational strategies. Sixty-eight percent agreed that FDP helped to improve skills in teaching of ethics and professionalism.  Results of focus group discussion show that faculty found program helpful in their grooming and development and it made them more knowledgeable. Views from individual interviews stated that faculty development program has contributed towards learning. Conclusion: In conclusion FDP at Shifa College of Medicine is valued by faculty. It has contributed towards excellence in teaching. This program should be continued with an endeavor to improve it further.
近年来,教师发展计划(FDP)对提高教学效果的重要性日益受到重视。我们努力改善师法医学院的教学方式,包括建立学生反馈机制、专业发展计划和教学研究。教师发展模式的调整适应了学术医学发展的新趋势。方法:通过问卷调查、焦点小组访谈和个人访谈等方式,收集教师的意见,以评估施法市医学院教师对FDP的看法。结果:超过一半的教师(51%-83%)认同与教学理念相关的各项内容,79%的教师认为他们学习了评估方法。73%的人认为这是介绍新教育策略的一个来源。68%的人认为,自由民主党帮助提高了道德和专业教育的技能。焦点小组讨论的结果表明,教师发现该计划有助于他们的修饰和发展,并使他们更有知识。从个人访谈的观点来看,教师发展计划对学习有所贡献。结论:Shifa医学院的FDP受到教师的重视。它有助于提高教学质量。这个项目应该继续下去,并努力进一步改进。
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引用次数: 1
Overlooked hepatotoxicity with Clopidogrel 氯吡格雷被忽视的肝毒性
Pub Date : 2020-12-23 DOI: 10.32593/JSTMU/VOL3.ISS2.100
J. Malik
Clopidogrel is an adenosine diphosphate receptor blocker. It is widely used as a part of dual antiplatelet therapy (DAPT) in patients with ischemic heart disease (IHD), regardless of the acute coronary syndrome (ACS). Although a rarely reported entity, clopidogrel-induced liver injury is commonly seen in clinical practice. It is widely overlooked by clinicians and is thus a potential hazard to patients with IHD.
氯吡格雷是一种二磷酸腺苷受体阻滞剂。它被广泛用于缺血性心脏病(IHD)患者的双重抗血小板治疗(DAPT)的一部分,无论急性冠脉综合征(ACS)。虽然很少报道,但氯吡格雷引起的肝损伤在临床实践中很常见。它被临床医生广泛忽视,因此对IHD患者是一种潜在的危险。
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引用次数: 0
Pathogenesis of COVID-19 associated with organ-based comorbidities 与器官合并症相关的COVID-19发病机制
Pub Date : 2020-12-23 DOI: 10.32593/JSTMU/VOL3.ISS2.90
Faiza Naseer, H. Bibi
The rapid outbreak of Covid-19 which emerged from severe acute respiratory syndrome coronavirus 2 infection, has lately become a worldwide emergency. This has caused an enormous adverse impact globally. In this review article, studies related to pathogenesis of Covid-19 related comorbidities with different organs are viewed and summarized.  
由严重急性呼吸综合征冠状病毒2型感染引起的Covid-19疫情迅速爆发,最近已成为全球紧急情况。这在全球范围内造成了巨大的不利影响。本文就新冠肺炎相关合并症与不同器官发病机制的相关研究进行综述。
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引用次数: 0
期刊
Journal of Shifa Tameer-e-Millat University
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