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Assessment of blood culture and tube agglutination serology test for the diagnosis of typhoid fever amongst malaria-negative patients: a one-year hospital-based study 血培养和管凝集血清学试验对疟疾阴性患者伤寒诊断的评估:一项为期一年的医院研究
Pub Date : 2023-06-19 DOI: 10.4081/hls.2023.11345
K. Nirmal, Vikas Saini, Nadeem Ahmad, Narendra Pal Singh
Salmonella serotypes, including Salmonella Typhi, S. Paratyphi A, S. Paratyphi B, and S. Paratyphi C, are responsible for the systemic, protracted febrile sickness known as typhoid fever. Various antibody-based tests are being used for diagnosing typhoid fever. This study was carried out to assess the performance of the widal test and blood culture for the diagnosis of typhoid fever among malaria-negative patients in a tertiary care hospital in east Delhi, India. The study was conducted from July 2021 to June 2022 in the Department of Microbiology of a tertiary care hospital in Delhi. Patients, including the adult and pediatric population, were evaluated for typhoid fever and participated in an observational, prospective study on febrile patients that was malaria-negative. Venous blood samples were obtained under strict aseptic conditions and further processed for widal serology and blood culture tests for typhoid fever. In our study, the prevalence of blood culture-positive Salmonella species was 0.3% (30/10,000 = 0.3%) Among antimicrobial susceptibility patterns, S. Typhi revealed the highest resistance rates for Ciprofloxacin (43.33%), Azithromycin (36.66%), and third-generation cephalosporins. Out of 30 blood culture-positive Salmonella Typhi of typhoid fever patients, 5 (17%) samples were negative for the Widal test. Among 30 samples, all were blood culture positive, but only 25 samples show Widal titer above the baseline i.e. >1:64. Although blood culture is the gold standard for the diagnosis of typhoid fever, the Widal test does play a role in the diagnosis and management of typhoid fever, especially in suspected cases when blood culture is negative, especially in government tertiary care hospitals.
沙门氏菌血清型,包括伤寒沙门氏菌、A型副伤寒沙门氏菌、B型副伤寒沙门氏菌和C型副伤寒沙门氏菌,可导致被称为伤寒的全身性、持续性发热性疾病。各种基于抗体的检测被用于诊断伤寒。本研究是在印度东德里的一家三级保健医院进行的,目的是评估用于诊断疟疾阴性患者伤寒的widal试验和血培养的性能。该研究于2021年7月至2022年6月在德里一家三级护理医院的微生物科进行。对包括成人和儿童在内的患者进行伤寒评估,并参与了一项对疟疾阴性发热患者的观察性前瞻性研究。静脉血在严格的无菌条件下采集,并进一步处理,进行伤寒血清和血培养试验。血培养阳性沙门氏菌的检出率为0.3%(30/ 10000 = 0.3%)。在药敏型中,伤寒沙门氏菌对环丙沙星(43.33%)、阿奇霉素(36.66%)和第三代头孢菌素的耐药率最高。在30例伤寒患者伤寒沙门氏菌血培养阳性的样本中,5例(17%)的维达尔试验呈阴性。30份样本全部血培养阳性,但只有25份样本的维达尔效价高于基线,即>1:64。虽然血培养是诊断伤寒的金标准,但维达尔试验确实在伤寒的诊断和管理中发挥作用,特别是在血培养阴性的疑似病例中,特别是在政府三级保健医院。
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引用次数: 0
Prevalence of MLSB Phenotypes of Staphylococcus aureus isolates in a tertiary care hospital of Delhi 德里一家三级护理医院分离的金黄色葡萄球菌MLSB表型的患病率
Pub Date : 2023-06-15 DOI: 10.4081/hls.2023.11229
Malika Grover, N. Goyal, Seema Gangar, N. Singh
Against the backdrop of the ever-changing Staphylococcal resistance pattern, clindamycin remains a viable therapeutic alternative Variation of Clindamycin drug resistance patterns with geographic area make inducible clindamycin resistance testing imperative for all staphylococcal isolates to avoid therapeutic failure. This was a prospective study conducted over a period of 1.5 years from January 2021 until June 2022. Prevalence of different MLSB Phenotypes of Staphylococcus aureus isolates was determined by standard disc diffusion method as per CLSI guidelines. Pyogenic samples received in the Microbiology lab that yielded Staphylococcus aureus were further tested for the presence of clindamycin resistance by disc diffusion method. Out of 6586 total pyogenic and respiratory specimens received in the lab, Staphylococcus aureus was yielded in 752 samples. On further testing for the MLSB phenotypes, 16.3% isolates were found to be iMLSB, 19.28% were cMLSB, 43.1% were of MSB type. ICR screening will reduce the unessential subjection of the patient to the antibiotic, and would prevent unnecessary adverse effects in the patients.
在葡萄球菌耐药性模式不断变化的背景下,克林霉素仍然是一种可行的治疗替代品。克林霉素耐药性模式随地理区域的变化使得所有葡萄球菌分离株都必须进行诱导型克林霉素耐药性检测,以避免治疗失败。这是一项前瞻性研究,从2021年1月到2022年6月,历时1.5年。根据CLSI指南,采用标准纸片扩散法测定金黄色葡萄球菌分离株不同MLSB表型的患病率。微生物实验室收到的产生金黄色葡萄球菌的致脓样品通过圆盘扩散法进一步检测是否存在克林霉素耐药性。在实验室收到的6586份化脓性和呼吸道样本中,752份样本中产生了金黄色葡萄球菌。进一步检测MLSB表型,发现16.3%的分离株为iMLSB,19.28%为cMLSB,43.1%为MSB型。ICR筛查将减少患者对抗生素的非必要接触,并防止患者出现不必要的不良反应。
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引用次数: 0
Value of biochemical markers in predicting outcome of COVID-19 infection in University Hospital, Alexandria, Egypt 埃及亚历山大大学医院生化标志物在预测新冠肺炎感染结果中的价值
Pub Date : 2023-06-08 DOI: 10.4081/hls.2023.11323
Neveen Rashad Mostafa, Abeer Ahmed Mohamed Ali, Rehab Moustafa Ezzat, Mostafa Kamel Bakry, R. Marzo
This paper aims to examine the value of different biochemical markers in predicting the outcome of COVID-19 infection. A total of 140 patients with confirmed COVID-19 infection by polymerase chain reaction (PCR), different biochemical markers were tested, their relation to the outcome of the disease was monitored, and the most reliable tests were determined. The study found a significant correlation between all evaluated biochemical markers and severity of the disease, including C-reactive protein (CRP), D-dimer, alanine aminotransferase (ALT), Aspartate aminotransferase (AST), prothrombin time (PT), activated partial thromboplastin time (aPTT). In addition, ferritin, lactate dehydrogenase (LDH), procalcitonin (PCT) and Pro- Brain natriuretic peptide (proBNP) demonstrated highly sensitivity and specificity as well as significant prognostic performance. These markers were also independently significant in predicting mortality. Early assessment of biochemical markers in patients with COVID-19 can help clinicians in tailoring treatment and providing more intensive care to those with greater mortality risk. In particular, the assessment of ferritin, LDH, procalcitonin and proBNP can independently predict mortality.
本文旨在检验不同生化标志物在预测新冠肺炎感染结果中的价值。对140例经聚合酶链式反应(PCR)确诊感染新冠肺炎的患者进行了不同的生化标志物检测,监测了它们与疾病结果的关系,并确定了最可靠的检测方法。研究发现,所有评估的生化标志物与疾病严重程度之间存在显著相关性,包括C反应蛋白(CRP)、D-二聚体、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶、凝血酶原时间(PT)和活化部分凝血活酶时间(aPTT)。此外,铁蛋白、乳酸脱氢酶(LDH)、降钙素原(PCT)和前脑钠肽(proBNP)显示出高度的敏感性和特异性以及显著的预后表现。这些标志物在预测死亡率方面也具有独立的显著性。对新冠肺炎患者的生物化学标志物进行早期评估可以帮助临床医生定制治疗,并为死亡率较高的患者提供更多重症监护。特别是,铁蛋白、LDH、降钙素原和BNP原的评估可以独立预测死亡率。
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引用次数: 0
Improving healthcare value: integrating medical practitioners into hospital design in developing countries 提高医疗保健价值:将医生纳入发展中国家的医院设计
Pub Date : 2023-06-08 DOI: 10.4081/hls.2023.11183
C. Noujeim
The cost of healthcare is a burden in most developing countries, and this is exponentially increasing in the context of population growth, pandemics, and rapidly evolving medical necessities. A customized healthcare typology should rely on data collection and architectural requirements, before moving to aesthetically compelling designs, so hospitals in low-resource or developing countries will not mimic their Western counterparts. The greatest bearing that improves the patient’s outcome and well-being would engage a productive interaction between the hospital designers and the medical practitioners, this will also allow for evidence-based hospital planning. As the author of this short report, I use the best of my experience as a physician and healthcare planner to translate a successful interaction with multinational designers building hospitals in Rivers State, Nigeria.
医疗保健成本是大多数发展中国家的负担,在人口增长、流行病和快速发展的医疗必需品的背景下,医疗保健成本呈指数级增长。定制的医疗保健类型应该依赖于数据收集和建筑要求,然后再转向美观的设计,这样资源匮乏或发展中国家的医院就不会模仿西方同行。改善患者预后和幸福感的最大影响是医院设计师和医生之间的富有成效的互动,这也将允许循证的医院规划。作为这份简短报告的作者,我利用我作为医生和医疗保健规划师的最佳经验,与在尼日利亚里弗斯州建造医院的跨国设计师进行了成功的互动。
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引用次数: 0
The effect of vitamin D deficiency on glycemic control in patients with type 2 diabetes mellitus 维生素D缺乏对2型糖尿病患者血糖控制的影响
Pub Date : 2023-06-08 DOI: 10.4081/hls.2023.11340
Neveen Rashad Mostafa, Abeer Ahmed Mohamed Ali, R. Marzo
Multiple factors are involved in the development of type 2 diabetes mellitus (T2DM), but an imbalance between free radical formation and antioxidant removal is the main cause of diabetic complications. Micronutrients with antioxidant properties may have a role in the development of diabetes mellitus (DM) and its complications. Vitamin D has recently been found to have membrane antioxidant effect and a relationship to the development of T2DM, as it can modify its risk. Whether vitamin D deficiency has an effect on hyperglycemia in diabetic patients or not need further study. Our aim was to examine the effect of vitamin D deficiency on glycemic control in T2DM. We examined the vitamin D levels of 100 patients with T2DM and correlated them with fasting blood sugar and glycated hemoglobin A1c (HbA1c) levels. High levels of fasting blood sugar and HbA1c levels were significantly associated with vitamin D deficiency. Vitamin D deficiency negatively affects glycemic control in patients with T2DM.
2型糖尿病(T2DM)的发展涉及多种因素,但自由基形成和抗氧化剂去除之间的不平衡是糖尿病并发症的主要原因。具有抗氧化特性的微量营养素可能在糖尿病及其并发症的发展中发挥作用。维生素D最近被发现具有膜抗氧化作用,并与T2DM的发展有关,因为它可以改变其风险。维生素D缺乏是否对糖尿病患者的高血糖有影响需要进一步研究。我们的目的是研究维生素D缺乏对T2DM血糖控制的影响。我们检测了100名T2DM患者的维生素D水平,并将其与空腹血糖和糖化血红蛋白A1c(HbA1c)水平相关联。高水平的空腹血糖和HbA1c水平与维生素D缺乏显著相关。维生素D缺乏会对T2DM患者的血糖控制产生负面影响。
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引用次数: 0
Maggot therapy could provide affordable and efficacious wound care in Lebanon and other low- and middle-income countries 在黎巴嫩和其他低收入和中等收入国家,蛆疗法可以提供负担得起的有效伤口护理
Pub Date : 2023-05-25 DOI: 10.4081/hls.2023.11161
Salman Shayya, F. Stadler
The poor economic situation, ongoing political instability, and the 2020 Beirut explosion have seriously eroded the capacity of the Lebanese healthcare system. Insecure fuel supplies and the rationing of electricity to a few hours per day make matters worse. New strategies are required to deliver healthcare that is more resilient in the face of ongoing disruption. Maggot therapy for the treatment of chronic and infected wounds could make a meaningful difference in Lebanon. When placed in a wound, medicinal maggots remove dead tissue, control infection and stimulate wound healing. It is an inexpensive, easy to use, and highly efficacious therapy, even under austere conditions. This review provides an introduction to maggot therapy and briefly explains its therapeutic benefits before discussing the role it can play in the Lebanese healthcare system. Finally, the prerequisites and enablers for successful integration of maggot therapy into the Lebanese healthcare system are outlined.
糟糕的经济形势、持续的政治不稳定以及2020年贝鲁特爆炸严重侵蚀了黎巴嫩医疗系统的能力。不安全的燃料供应和每天几个小时的限电使情况变得更糟。需要新的战略来提供在面临持续中断时更具弹性的医疗保健。Maggot治疗慢性和感染性伤口可以在黎巴嫩产生有意义的影响。当放置在伤口中时,药用蛆可以去除死组织,控制感染并刺激伤口愈合。它是一种便宜、易用、高效的治疗方法,即使在恶劣的条件下也是如此。这篇综述介绍了蛆疗法,并简要解释了其治疗益处,然后讨论了它在黎巴嫩医疗系统中的作用。最后,概述了将蛆虫疗法成功融入黎巴嫩医疗系统的先决条件和促成因素。
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引用次数: 0
Fear of COVID-19 among critical care nurses of public hospitals in Lahore: empirical evidence during third wave 拉合尔公立医院重症监护护士对COVID-19的恐惧:第三次浪潮期间的经验证据
Pub Date : 2023-05-18 DOI: 10.4081/hls.2023.10642
Asma Nadeem, Rubina Jabeen, Shehla Nazir, Shahbaz Haider
The world has seen a pandemic which disrupted the life. Till now there are aftershocks of the COVID-19 such as Omicron instilling fear among individuals. Healthcare staff is on alert specifically the nurses has suffered a lot mentally due to this issue by developing fatigue. The study conducted during deadly 3rd COVID-19 wave. The data were collected by developing the questionnaire of the previously validated measures related to the variables under study from nurses working in the intensive care unit, critical care unit and floor wards of COVID-19 at Services Hospital, Lahore. A total of 140 questionnaires were used for data analysis. The study used Statistical Package for Social Sciences for frequency and descriptive statistics. Whereas, the outcomes of fear of COVID-19 were assessed by using the latest Smart Partial Least Squares software which allows to assess the complex research frameworks. The results of the study revealed that the fear of COVID-19 results in poor quality of life among nurses and fatigue. Resilience among nurses can reduce the negative consequences but did not get the statistical support.
世界经历了一场扰乱生活的大流行。到目前为止,新冠病毒的“欧米克隆”(Omicron)等余震正在给人们带来恐惧。医护人员保持警惕,特别是护士,由于这个问题,他们的精神上受到了很大的影响,产生了疲劳。这项研究是在致命的第三次COVID-19浪潮期间进行的。数据是通过编制问卷,对在拉合尔服务医院COVID-19重症监护病房、重症监护病房和底层病房工作的护士进行的与研究变量相关的先前验证措施进行收集。共使用140份问卷进行数据分析。该研究使用社会科学统计包进行频率和描述性统计。鉴于对COVID-19恐惧的结果使用最新的智能偏最小二乘软件进行评估,该软件允许评估复杂的研究框架。研究结果显示,对COVID-19的恐惧导致护士的生活质量下降和疲劳。护士的心理弹性可以减少不良后果,但没有得到统计支持。
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引用次数: 0
Analysis of the potential reasons for repeated radiography: a study in a major hospital in south eastern Iran 伊朗东南部一家大型医院重复放射线照相的潜在原因分析
Pub Date : 2023-05-18 DOI: 10.4081/hls.2023.10575
H. Dahmarde, Marzieh Abiri, Sharareh Sanei Sistani
Introduction Rejecting, removing and repeating the process of taking diagnostic X-ray images could lead to professional and moral challenges in the case of radiologic imaging. The aim of this study was to investigate the reason for repetitive imaging and the types of images mostly repeated.  Methods Radiographic images taken in this center in the first half of 1400 were evaluated. At the end of each week, repetitive images were referred to the researcher to analyze the frequency of repetitive radiographies and the causes. Results In this study, a total of 4916 radiographies taken in Ali Ibn-e-Abitibi Hospital during the first 6 months of the year 1400 were evaluated. Among 398 repetitive radiographies, 94 repetitions (23.62%) were due to inappropriate positioning, 92 repetitions (23.12%) were due to patient's movements, 56 repetitions (14.07%) were due to inadequate radiation, 51 repetitions (12.81%) were due to inadequate processing, 46 repetitions (11.56%) were due to inadequate preparation of the patient, and 59 repetitions(14.82 %) were due to other reasons Conclusion In this study, the rate of repetitive radiographies taken in Ali Ibn-e-Abi Talib Hospital was estimated as 8.10%, with the most common reason for repetitions being estimated inappropriate positioning. Considering the fact that repetitive radiography mostly depends on operator-related factors, it is recommended to repeat the study after educating staff in order to compare the rate and reason of repetition. 
引言在放射学成像的情况下,拒绝、删除和重复拍摄诊断性X射线图像的过程可能会导致职业和道德上的挑战。本研究的目的是调查重复成像的原因以及大多数重复成像的类型。方法对1400年上半年在该中心拍摄的影像进行评价。在每周末,重复的图像被提交给研究人员,以分析重复射线照片的频率和原因。结果在本研究中,对1400年前6个月在Ali Ibn-e-Abitibi医院拍摄的4916张射线照片进行了评估。在398张重复射线照片中,94次重复(23.62%)是由于定位不当,92次重复(23.12%)是由于患者的运动,56次重复(14.07%)是由于辐射不足,51次重复(12.81%)是由于处理不当,46次重复(11.56%)是由于对患者的准备不足,59次重复(14.82%)是由于其他原因造成的。结论在本研究中,在Ali Ibn-e-Abi Talib医院拍摄的重复射线照片的比率估计为8.10%,重复的最常见原因是估计位置不合适。考虑到重复放射线照相主要取决于操作员相关因素,建议在教育员工后重复研究,以比较重复率和原因。
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引用次数: 0
High-grade cervical intraepithelial neoplasia treatment comparing two photodynamic therapy protocols 高级别宫颈上皮内瘤变治疗比较两种光动力治疗方案
Pub Date : 2023-03-27 DOI: 10.1117/12.2647382
N. Inada, C. A. de Castro, C. F. da Silva, W. Lombardi, Vanderlei Salvador Bagnato
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引用次数: 0
Front Matter: Volume 12369 封面:12369卷
Pub Date : 2023-03-24 DOI: 10.1117/12.2676204
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引用次数: 0
期刊
Healthcare in Lowresource Settings
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