Pub Date : 2023-09-01DOI: 10.33320/maced.pharm.bull.2023.69.03.128
Teodora Tasevska, Lina Livrinska, Ljubica Mihailova, Dushko Shalabalija, Nikola Geskovski, Marija Glavas Dodov, Katerina Goracinova, Kristina Mladenovska, Renata Slaveska Raichki, Maja Simonoska Crcarevska
In recent years, the research and development of new dosage forms manufactured by 3D bioprinting technique (3DP) has been increasing. The polymeric materials used in 3DP (bioinks) should possess certain biological as well as mechanical and rheological characteristics. Their rheological behaviour, viscosity, elasticity and plasticity significantly influence the manufacturing process. The determination of rheological properties is essential from the point of view of uniform dispersion of the active substances, stress during controlled extrusion, liquefaction of bioinks during extrusion through the small orifices of printing nozzles, viscoelastic properties for protection against shear stress, thixotropy, the possibility of gelation, etc. Poloxamer 407 (P407) is widely used in different pharmaceutical products, but also shows great potential in 3DP as bioink due to its thermogelling characteristics (Dumortier et al., 2006). The aim of this study was to establish and validate a method for the rheological characterization of P407 hydrogel, as one of the most commonly used biopolymers for 3DP. The paper of Simões at al. (2020) was used as a guide for the validation.
{"title":"Validation of method for rheological characterization of poloxamer 407 hydrogels used for 3D bioprinting","authors":"Teodora Tasevska, Lina Livrinska, Ljubica Mihailova, Dushko Shalabalija, Nikola Geskovski, Marija Glavas Dodov, Katerina Goracinova, Kristina Mladenovska, Renata Slaveska Raichki, Maja Simonoska Crcarevska","doi":"10.33320/maced.pharm.bull.2023.69.03.128","DOIUrl":"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.128","url":null,"abstract":"In recent years, the research and development of new dosage forms manufactured by 3D bioprinting technique (3DP) has been increasing. The polymeric materials used in 3DP (bioinks) should possess certain biological as well as mechanical and rheological characteristics. Their rheological behaviour, viscosity, elasticity and plasticity significantly influence the manufacturing process. The determination of rheological properties is essential from the point of view of uniform dispersion of the active substances, stress during controlled extrusion, liquefaction of bioinks during extrusion through the small orifices of printing nozzles, viscoelastic properties for protection against shear stress, thixotropy, the possibility of gelation, etc. Poloxamer 407 (P407) is widely used in different pharmaceutical products, but also shows great potential in 3DP as bioink due to its thermogelling characteristics (Dumortier et al., 2006). The aim of this study was to establish and validate a method for the rheological characterization of P407 hydrogel, as one of the most commonly used biopolymers for 3DP. The paper of Simões at al. (2020) was used as a guide for the validation.","PeriodicalId":30550,"journal":{"name":"Makedonsko Farmacevtski Bilten","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.33320/maced.pharm.bull.2023.69.03.125
Gentiana Mehmeti, Nikola Geshkovski, Katerina Brezovska, Aneta Dimitrovska, Suzana Trajkovic Jolevska, Rumenka Petkovska, Jelena Acevska
Many strategies are being reported to combat the occurrence of substandard and falsified medicines (Bakker-’t Hart, Ohana, Venhuis, 2021; Sweileh, 2021). Determination of characteristic analytical profile (i.e fingerprints) in combination with pattern recognition models can allow differentiation between samples by origin (manufacturer or location), authentication of suspicious samples, and successful detection of falsified samples (Been et al. 2011; Custers et al., 2016; Dégardin et al., 2016, Henrique, Scafia & Pasquini, 2001, Mazivila & Olivieri, 2018; Rebiere et al. 2017). Such fingerprints can reveal information on the manufacturing process, as well as the distribution history of the medicines. Even though technological development provides many smart algorithm-based systems that can help in revealing the hidden differences among set of similar samples, the problem of falsification is still very present and pose huge healthcare, as well as regulatory problem (Roth, Biggs & Bempong, 2019). The forgers expect and often find a way around the approved quality specification of the medicine. The pipeline for successful prevention of the occurrence of falsified medicines on a market is restricted resources for testing outside the specification requirements (Hamilton et al. 2016). Therefore, it is crucial to select the samples with suspicion to be falsified, based on critical risk factors, like: patient safety, number of suppliers and regulatory background, possibility of drug shortages, current regulatory requirements, etc. For such medicines, a comprehensive strategy to reveal their origin must be anticipated. There should be elaborated background research to reveal the possible discriminatory analytical features, which will enable the differentiation between authentic and suspect-full falsification. The aim of the research was elaborate on the discriminatory strength of the proposed comprehensive analytical methodology for the differentiation of the origin of samples with high-risk scores for the occurrence of falsification in the Republic of Kosovo.
{"title":"Analytical strategy for discrimination between different origins of Metformin film-coated tablets","authors":"Gentiana Mehmeti, Nikola Geshkovski, Katerina Brezovska, Aneta Dimitrovska, Suzana Trajkovic Jolevska, Rumenka Petkovska, Jelena Acevska","doi":"10.33320/maced.pharm.bull.2023.69.03.125","DOIUrl":"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.125","url":null,"abstract":"Many strategies are being reported to combat the occurrence of substandard and falsified medicines (Bakker-’t Hart, Ohana, Venhuis, 2021; Sweileh, 2021). Determination of characteristic analytical profile (i.e fingerprints) in combination with pattern recognition models can allow differentiation between samples by origin (manufacturer or location), authentication of suspicious samples, and successful detection of falsified samples (Been et al. 2011; Custers et al., 2016; Dégardin et al., 2016, Henrique, Scafia & Pasquini, 2001, Mazivila & Olivieri, 2018; Rebiere et al. 2017). Such fingerprints can reveal information on the manufacturing process, as well as the distribution history of the medicines. Even though technological development provides many smart algorithm-based systems that can help in revealing the hidden differences among set of similar samples, the problem of falsification is still very present and pose huge healthcare, as well as regulatory problem (Roth, Biggs & Bempong, 2019). The forgers expect and often find a way around the approved quality specification of the medicine. The pipeline for successful prevention of the occurrence of falsified medicines on a market is restricted resources for testing outside the specification requirements (Hamilton et al. 2016). Therefore, it is crucial to select the samples with suspicion to be falsified, based on critical risk factors, like: patient safety, number of suppliers and regulatory background, possibility of drug shortages, current regulatory requirements, etc. For such medicines, a comprehensive strategy to reveal their origin must be anticipated. There should be elaborated background research to reveal the possible discriminatory analytical features, which will enable the differentiation between authentic and suspect-full falsification. The aim of the research was elaborate on the discriminatory strength of the proposed comprehensive analytical methodology for the differentiation of the origin of samples with high-risk scores for the occurrence of falsification in the Republic of Kosovo.","PeriodicalId":30550,"journal":{"name":"Makedonsko Farmacevtski Bilten","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.33320/maced.pharm.bull.2023.69.03.113
Damjan Shushleski, Marjan Velkovski, Irena Slaveska Spirevska
Sildenafil is a medication used to treat pulmonary arterial hypertension and erectile dysfunction. It is taken by mouth or by injection into a vein. Onset is typically within twenty minutes and lasts for about two hours. Mechanism of act of sildenafil is by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, in the smooth muscle cells lining the blood vessels supplying various tissues. It also results in dilation of the blood vessels in the lungs (Cocci et al., 2017). All pharmaceutical forms are subject to chemical and microbiological quality control. A microbiological quality control method that will be used in routine analysis for determination of product microbiological purity must be subject of validation. Microbiological quality control parameters for Sildenafil film coated tablets 100 mg as non-aqueous pharmaceutical preparation for oral use are: Total Aerobic Microbial Count (TAMC), Total Yeasts and Molds Count (TYMC) and Absence of Escherichia coli (Ph.Eur. 10.0, 2019).
{"title":"Method suitability validation for determination of microbiological purity of Sildenafil film-coated tablet","authors":"Damjan Shushleski, Marjan Velkovski, Irena Slaveska Spirevska","doi":"10.33320/maced.pharm.bull.2023.69.03.113","DOIUrl":"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.113","url":null,"abstract":"Sildenafil is a medication used to treat pulmonary arterial hypertension and erectile dysfunction. It is taken by mouth or by injection into a vein. Onset is typically within twenty minutes and lasts for about two hours. Mechanism of act of sildenafil is by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, in the smooth muscle cells lining the blood vessels supplying various tissues. It also results in dilation of the blood vessels in the lungs (Cocci et al., 2017). All pharmaceutical forms are subject to chemical and microbiological quality control. A microbiological quality control method that will be used in routine analysis for determination of product microbiological purity must be subject of validation. Microbiological quality control parameters for Sildenafil film coated tablets 100 mg as non-aqueous pharmaceutical preparation for oral use are: Total Aerobic Microbial Count (TAMC), Total Yeasts and Molds Count (TYMC) and Absence of Escherichia coli (Ph.Eur. 10.0, 2019).","PeriodicalId":30550,"journal":{"name":"Makedonsko Farmacevtski Bilten","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.33320/maced.pharm.bull.2023.69.03.127
Ana Marija Bajatovska, Zoran Zhivikj, Kristina Shutevska, Marija Karapandzova, Tanja Petreska Ivanovska, Lidija Petrushevska-Tozi, Tatjana Kadifkova Panovska
Tea is one of the most widely consumed beverages in the world. Significant share of tea sales is intended for weight loss and preventing weight gain and obesity. However, evidence-based data for the efficacy of weight loss teas is missing due to the conflicting results obtained in different studies (Rothenberg et al., 2018). Furthermore, these products are subjected to much less rigorous regulation compared to prescription medications (Farrington et al., 2019), and can lead to inconsistent quality and questionable safety. Commercially available weight loss teas are usually herbal mixtures that can result in adverse or toxic effects due to possible interactions of multiple active ingredients. The aim of our study was to determine the potential toxicity of weight loss tea products from different manufacturers using the Brine Shrimp Lethality Assay (BSLA).
{"title":"Toxicity screening of weight loss tea products by Brine Shrimp Lethality Assay","authors":"Ana Marija Bajatovska, Zoran Zhivikj, Kristina Shutevska, Marija Karapandzova, Tanja Petreska Ivanovska, Lidija Petrushevska-Tozi, Tatjana Kadifkova Panovska","doi":"10.33320/maced.pharm.bull.2023.69.03.127","DOIUrl":"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.127","url":null,"abstract":"Tea is one of the most widely consumed beverages in the world. Significant share of tea sales is intended for weight loss and preventing weight gain and obesity. However, evidence-based data for the efficacy of weight loss teas is missing due to the conflicting results obtained in different studies (Rothenberg et al., 2018). Furthermore, these products are subjected to much less rigorous regulation compared to prescription medications (Farrington et al., 2019), and can lead to inconsistent quality and questionable safety. Commercially available weight loss teas are usually herbal mixtures that can result in adverse or toxic effects due to possible interactions of multiple active ingredients. The aim of our study was to determine the potential toxicity of weight loss tea products from different manufacturers using the Brine Shrimp Lethality Assay (BSLA).","PeriodicalId":30550,"journal":{"name":"Makedonsko Farmacevtski Bilten","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.33320/maced.pharm.bull.2023.69.03.118
Bartłomiej Milanowski, Mateusz Kuprianowicz
Biorelevant dissolution tests of oral solid dosage forms open the gate to valid in vitro-in vivo predictions (IVIVP). A recently developed Revolver apparatus (Fig. 1) allows mimicking the acceptor fluid composition and flow as well as pH changes occurring in the human fasted intestine. This work presents and showcases the first application of the Revolver in dissolution testing of SR tablets with ropinirole hydrochloride (RH).
{"title":"Application of a novel Revolver apparatus for a biorelevant dissolution test of ropinirole sustained release tablets","authors":"Bartłomiej Milanowski, Mateusz Kuprianowicz","doi":"10.33320/maced.pharm.bull.2023.69.03.118","DOIUrl":"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.118","url":null,"abstract":"Biorelevant dissolution tests of oral solid dosage forms open the gate to valid in vitro-in vivo predictions (IVIVP). A recently developed Revolver apparatus (Fig. 1) allows mimicking the acceptor fluid composition and flow as well as pH changes occurring in the human fasted intestine. This work presents and showcases the first application of the Revolver in dissolution testing of SR tablets with ropinirole hydrochloride (RH).","PeriodicalId":30550,"journal":{"name":"Makedonsko Farmacevtski Bilten","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.33320/maced.pharm.bull.2023.69.03.131
Katarina Ilić, Jelena Zvezdanović, Jelena Lazarević
Trough recent studies, aging, cancer, atherosclerosis, and some other serious diseases have been confirmed to correlate with low density lipoprotein (LDL), cell membranes, and DNA exposed to oxidative stress (Finkel et al., 2000). In conditions of oxidative stress, in interaction with generated free radicals, polyunsaturated fatty acids can undergo oxidative damage, which results in the initiation of lipid peroxidation (LP). Oxidative stress and the resulting LP are involved in the pathogenesis of numerous chronic and degenerative diseases which seriously impair the quality of life (Pinchuk et al., 2012). That is why numerous researches are aimed at finding substances with antioxidant properties. Coumarins are scaffolds widely distributed in nature, possess numerous therapeutic applications including photochemotherapy, antitumor and anti-HIV therapy (Borges et al., 2005). They are proven antibacterial and anti-inflammatory agents, and anti-coagulants. In addition to a wide array of pharmacological activities, several evidences indicate that coumarins may act as antioxidants or regulator of antioxidant activity (Pérez-Cruz et al., 2012). Although reported papers can be related to an antioxidant activity of coumarins, the characterization of the antioxidant profile of coumarins is at present lacking. In this study the evaluation of antioxidative properties of four synthetic coumarin derivatives have been investigated by a LP assay.
{"title":"Synthesis and evaluation of lipid peroxidase inhibition of 4-methyl substituted coumarins","authors":"Katarina Ilić, Jelena Zvezdanović, Jelena Lazarević","doi":"10.33320/maced.pharm.bull.2023.69.03.131","DOIUrl":"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.131","url":null,"abstract":"Trough recent studies, aging, cancer, atherosclerosis, and some other serious diseases have been confirmed to correlate with low density lipoprotein (LDL), cell membranes, and DNA exposed to oxidative stress (Finkel et al., 2000). In conditions of oxidative stress, in interaction with generated free radicals, polyunsaturated fatty acids can undergo oxidative damage, which results in the initiation of lipid peroxidation (LP). Oxidative stress and the resulting LP are involved in the pathogenesis of numerous chronic and degenerative diseases which seriously impair the quality of life (Pinchuk et al., 2012). That is why numerous researches are aimed at finding substances with antioxidant properties. Coumarins are scaffolds widely distributed in nature, possess numerous therapeutic applications including photochemotherapy, antitumor and anti-HIV therapy (Borges et al., 2005). They are proven antibacterial and anti-inflammatory agents, and anti-coagulants. In addition to a wide array of pharmacological activities, several evidences indicate that coumarins may act as antioxidants or regulator of antioxidant activity (Pérez-Cruz et al., 2012). Although reported papers can be related to an antioxidant activity of coumarins, the characterization of the antioxidant profile of coumarins is at present lacking. In this study the evaluation of antioxidative properties of four synthetic coumarin derivatives have been investigated by a LP assay.","PeriodicalId":30550,"journal":{"name":"Makedonsko Farmacevtski Bilten","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134918138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.33320/maced.pharm.bull.2023.69.03.122
Iskra Davkova, Ivana Cvetkovikj Karanfilova, Ana Trajkovska, Veronika Stoilkovska Gjorgievska, Svetlana Kulevanova, Gjoshe Stefkov, Marija Karapandzova
Cannabis is one of the most attractive plants nowadays since it is being part of many herbal products, alternative medicine and street illegal use for different purposes. Stability of the herbal raw materials often determinates shelf-life of the final product. Maintaining the storage conditions of the herbal raw materials is a direct requirement for the quality of the final product. Temperature is one of the critical parameters that affect the stability of almost all herbal raw materials, especially those containing heat-sensitive compounds such as Cannabis. This plant contains more than 100 different chemicals called cannabinoids. When cannabinoids are extracted from herbal material or resin into organic solvents, both the temperature and light exposure is shown to influence their stability. It is, however, important to distinguish the degradation of neutral and acidic species (Lindholst, 2010). Different storage conditions leads to different cannabis chemical composition and content. Cannabinoids, the plant active components, are similar to the compounds the body makes and are involved in appetite, memory, movement, and pain. There are lot of certain medical conditions that require high THC content, therefore reducing it can lead to an undesirable outcome. Regarding this, the content of dried cannabis THC flowers stored at different conditions were analyzed.
{"title":"Effects of temperature on THC and THCA content during storage","authors":"Iskra Davkova, Ivana Cvetkovikj Karanfilova, Ana Trajkovska, Veronika Stoilkovska Gjorgievska, Svetlana Kulevanova, Gjoshe Stefkov, Marija Karapandzova","doi":"10.33320/maced.pharm.bull.2023.69.03.122","DOIUrl":"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.122","url":null,"abstract":"Cannabis is one of the most attractive plants nowadays since it is being part of many herbal products, alternative medicine and street illegal use for different purposes. Stability of the herbal raw materials often determinates shelf-life of the final product. Maintaining the storage conditions of the herbal raw materials is a direct requirement for the quality of the final product. Temperature is one of the critical parameters that affect the stability of almost all herbal raw materials, especially those containing heat-sensitive compounds such as Cannabis. This plant contains more than 100 different chemicals called cannabinoids. When cannabinoids are extracted from herbal material or resin into organic solvents, both the temperature and light exposure is shown to influence their stability. It is, however, important to distinguish the degradation of neutral and acidic species (Lindholst, 2010). Different storage conditions leads to different cannabis chemical composition and content. Cannabinoids, the plant active components, are similar to the compounds the body makes and are involved in appetite, memory, movement, and pain. There are lot of certain medical conditions that require high THC content, therefore reducing it can lead to an undesirable outcome. Regarding this, the content of dried cannabis THC flowers stored at different conditions were analyzed.","PeriodicalId":30550,"journal":{"name":"Makedonsko Farmacevtski Bilten","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135249325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.33320/maced.pharm.bull.2023.69.03.126
Zoran Zhivikj, Lidija Petrushevska-Tozi, Nikola Geskovski, Kristina Shutevska, Ana Marija Bajatovska, Marija Karapandzova, Tatjana Kadifkova Panovska, Tanja Petreska Ivanovska
University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy, Institute of Applied Biochemistry, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy, Institute of Pharmaceutical Technology, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy, Institute of Pharmacognosy, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia
{"title":"Evaluation of weight loss supplements toxicity in rifampicin pretreated HepG2 cells","authors":"Zoran Zhivikj, Lidija Petrushevska-Tozi, Nikola Geskovski, Kristina Shutevska, Ana Marija Bajatovska, Marija Karapandzova, Tatjana Kadifkova Panovska, Tanja Petreska Ivanovska","doi":"10.33320/maced.pharm.bull.2023.69.03.126","DOIUrl":"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.126","url":null,"abstract":"University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy, Institute of Applied Biochemistry, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy, Institute of Pharmaceutical Technology, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy, Institute of Pharmacognosy, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia","PeriodicalId":30550,"journal":{"name":"Makedonsko Farmacevtski Bilten","volume":"194 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135249542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.33320/maced.pharm.bull.2023.69.03.141
Erna Turković, Elena Velkoska, Ana Marija Nančeva, Ivana Vasiljević, Katerina Goračinova, Jelena Parojčić
Semi-solid 3D printing technology has gained increased interest in the pharmaceutical field as it enables on-demand fabrication of personalized dosage forms. Orodispersible films (ODFs) are good candidates for 3D printing because of their relatively simple formulation, flexible dosing, and suitability for administration in different populations. The aim of this work was to investigate the applicability of sodium carboxymethyl cellulose and sodium alginate as film-forming agents for 3D printed ODFs incorporating amlodipine or warfarin as selected model active pharmaceutical ingredients (API).
{"title":"An investigation into applicability of sodium carboxymethylcellulose and sodium alginate as film-forming agents for semi-solid 3D printing","authors":"Erna Turković, Elena Velkoska, Ana Marija Nančeva, Ivana Vasiljević, Katerina Goračinova, Jelena Parojčić","doi":"10.33320/maced.pharm.bull.2023.69.03.141","DOIUrl":"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.141","url":null,"abstract":"Semi-solid 3D printing technology has gained increased interest in the pharmaceutical field as it enables on-demand fabrication of personalized dosage forms. Orodispersible films (ODFs) are good candidates for 3D printing because of their relatively simple formulation, flexible dosing, and suitability for administration in different populations. The aim of this work was to investigate the applicability of sodium carboxymethyl cellulose and sodium alginate as film-forming agents for 3D printed ODFs incorporating amlodipine or warfarin as selected model active pharmaceutical ingredients (API).","PeriodicalId":30550,"journal":{"name":"Makedonsko Farmacevtski Bilten","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.33320/maced.pharm.bull.2023.69.03.140
Ivana Vasiljević, Paulina Pasik, Erna Turković, Branka Ivković, Arkadiusz Hejduk, Janina Lulek, Jelena Parojčić
Department of Pharmaceutical Technology and Cosmetology, University of Belgrade – Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia, 2 Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland, Department of Pharmaceutical Chemistry, University of Belgrade – Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia, LEK-AM Pharmaceutical Company Ltd, Ostrzykowizna 14A, 05-170 Zakroczym, Poland
{"title":"The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban","authors":"Ivana Vasiljević, Paulina Pasik, Erna Turković, Branka Ivković, Arkadiusz Hejduk, Janina Lulek, Jelena Parojčić","doi":"10.33320/maced.pharm.bull.2023.69.03.140","DOIUrl":"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.140","url":null,"abstract":"Department of Pharmaceutical Technology and Cosmetology, University of Belgrade – Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia, 2 Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland, Department of Pharmaceutical Chemistry, University of Belgrade – Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia, LEK-AM Pharmaceutical Company Ltd, Ostrzykowizna 14A, 05-170 Zakroczym, Poland","PeriodicalId":30550,"journal":{"name":"Makedonsko Farmacevtski Bilten","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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