Arvind Nilkanthrao Chavan, Saleem H. Tambe, Mangesh Karemore, Ismail A Inamdar, Pratiksha Dhurve
Abstract Background: Thrombocytopenia is a frequent problem in neonatal sepsis and is among the most predictive, independent risk factors for sepsis-associated mortality. The present study was undertaken to correlate neonatal sepsis and thrombocytopenia in terms of severity, clinical course, organism specificity and outcome. Method: Total 384 neonates age <28 days with sepsis and thrombocytopenia were studied and analyzed with their clinical profile, symptoms, lab findings and outcomes. Results: Male babies (55.86%), age <72 hrs (80.35%), preterm (68.70%) and LBW babies (85.58%) were more prone to sepsis. Maternal fever (67.44%), foul smelling liquor (53.79%) and PROM >18 hrs (66.74%) make babies more prone to neonatal sepsis. The Commonest clinical features were not accepting feed (69.95%), lethargy (67.85%) and breathing difficulty (79.04%). Early onset sepsis (82.54%) and probable sepsis (40.26%) were more common and associated with preterm and LBW babies. Leucocytosis was seen in 64.57%, thrombocytopenia moderate degree 45.67% and severe degree 34.65%, MPV >12 69.11%, ANC <1800 47.50%, micro ESR >15 mm 72.16% and CRP positivity 28.60%. Severe degree thrombocytopenia (<50000) was more common with PROM >18 hrs (83.02%), maternal fever (83.09%) and gram-negative organism(61.29%). Leucopenia (<4000) was more common with maternal fever (75.79%), proven sepsis (43.16%) and gram-negative organism (70.31%). Severe degree thrombocytopenia (61.29%), leucopenia (70.31%) and mortality (64.51%) were more commonly associated with gram-negative organism. Outcome was bad with severe degree of thrombocytopenia (62.32%), leucopenia (73.91%), and gram-negative organism (64.51%). Conclusion: Proper antenatal mother care, hygiene and early evaluation for illness can prevent early onset of sepsis in neonates. Severity of degree of thrombocytopenia directly proportional to the worst outcome.
背景:血小板减少症是新生儿脓毒症的常见问题，也是脓毒症相关死亡率最具预测性的独立危险因素之一。本研究旨在探讨新生儿脓毒症和血小板减少症在严重程度、临床病程、机体特异性和预后方面的相关性。方法:384例18小时新生儿(66.74%)易发生新生儿败血症。最常见的临床特征为不进食(69.95%)、嗜睡(67.85%)和呼吸困难(79.04%)。早发性脓毒症(82.54%)和可能的脓毒症(40.26%)更为常见，并与早产和低体重儿相关。白细胞减少64.57%，中度血小板减少45.67%，重度血小板减少34.65%，MPV bbb12 69.11%， ANC 15 mm 72.16%， CRP阳性28.60%。重度血小板减少(18小时)(83.02%)，产妇发热(83.09%)和革兰氏阴性菌(61.29%)。白细胞减少(<4000)在产妇发热(75.79%)、确诊败血症(43.16%)和革兰氏阴性菌(70.31%)中更为常见。重度血小板减少症(61.29%)、白细胞减少症(70.31%)和死亡率(64.51%)与革兰氏阴性菌相关。结果较差，重度血小板减少(62.32%)、白细胞减少(73.91%)和革兰氏阴性菌(64.51%)。结论:正确的母婴护理、卫生及疾病早期评估可预防新生儿早发性败血症。血小板减少的严重程度与最坏的结果成正比。
{"title":"Study of Clinical and Outcome Profile of Neonatal Sepsis with Thrombocytopenia Patients Admitted at Tertiary health care Centre Nanded","authors":"Arvind Nilkanthrao Chavan, Saleem H. Tambe, Mangesh Karemore, Ismail A Inamdar, Pratiksha Dhurve","doi":"10.47799/pimr.1003.17","DOIUrl":"https://doi.org/10.47799/pimr.1003.17","url":null,"abstract":"Abstract\u0000 \u0000 Background: Thrombocytopenia is a frequent problem in neonatal sepsis and is among the most predictive, independent risk factors for sepsis-associated mortality. The present study was undertaken to correlate neonatal sepsis and thrombocytopenia in terms of severity, clinical course, organism specificity and outcome. Method:\u0000 Total 384 neonates age <28 days with sepsis and thrombocytopenia were studied and analyzed with their clinical profile, symptoms, lab findings and outcomes. Results: Male babies (55.86%), age <72 hrs (80.35%), preterm (68.70%) and LBW babies (85.58%) were more prone to sepsis. Maternal fever (67.44%), foul smelling liquor (53.79%) and PROM >18 hrs (66.74%) make babies more prone to neonatal sepsis. The Commonest clinical features were not accepting feed (69.95%), lethargy (67.85%) and breathing difficulty (79.04%). Early onset sepsis (82.54%) and probable sepsis (40.26%) were more common and associated with preterm and LBW babies. Leucocytosis was seen in 64.57%, thrombocytopenia moderate degree 45.67% and severe degree 34.65%, MPV >12 69.11%, ANC <1800 47.50%, micro ESR >15 mm 72.16% and CRP positivity 28.60%. Severe degree thrombocytopenia (<50000) was more common with PROM >18 hrs (83.02%), maternal fever (83.09%) and gram-negative organism(61.29%). Leucopenia (<4000) was more common with maternal fever (75.79%), proven sepsis (43.16%) and gram-negative organism (70.31%). Severe degree thrombocytopenia (61.29%), leucopenia (70.31%) and mortality (64.51%) were more commonly associated with gram-negative organism. Outcome was bad with severe degree of thrombocytopenia (62.32%), leucopenia (73.91%), and gram-negative organism (64.51%). Conclusion: Proper antenatal mother care, hygiene and early evaluation for illness can prevent early onset of sepsis in neonates. Severity of degree of thrombocytopenia directly proportional to the worst outcome.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46857185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haseeb ul Haq, S. Raghunath, Channamaneni Amithkumar
Abstract Introduction: Predictive markers enabling Pediatricians to identify which neonates will develop jaundice have mandatory for prevention of severe hyperbilirubinemia. We aim to determine the critical cord bilirubin and albumin levels and bilirubin/albumin ratio. Design: This prospective study included131full-termnewborns. Hyperbilirubinemia can be predicted by Measuring cord bilirubin , albumin and bilirubin/albumin ratio. Results: Neonatal hyperbilirubinemia (67.8%) had cord albumin level less than or equal to 2.7gm/dl. CordBilirubin/albumin ratio cutoff value greater than 0.62 had a good predictive value with a sensitivity of 100% and specificity of 88.36%, Conclusion: neonatal hyperbilirubinemia predictors are Cord BILIRUBIN/ALBUMIN ratio , serum bilirubin and albumin.
{"title":"Early Predictors of Hyperbilirubinemia in Full Term Newborn","authors":"Haseeb ul Haq, S. Raghunath, Channamaneni Amithkumar","doi":"10.47799/pimr.1003.18","DOIUrl":"https://doi.org/10.47799/pimr.1003.18","url":null,"abstract":"Abstract\u0000 \u0000 Introduction: Predictive markers enabling Pediatricians to identify which neonates will develop jaundice have mandatory for prevention of severe hyperbilirubinemia. We aim to determine the critical cord bilirubin and albumin levels and bilirubin/albumin ratio.\u0000 \u0000 Design: This prospective study included131full-termnewborns. Hyperbilirubinemia can be predicted by Measuring cord bilirubin , albumin and bilirubin/albumin ratio.\u0000 \u0000 Results: Neonatal hyperbilirubinemia (67.8%) had cord albumin level less than or equal to 2.7gm/dl. CordBilirubin/albumin ratio cutoff value greater than 0.62 had a good predictive value with a sensitivity of 100% and specificity of 88.36%,\u0000 \u0000 Conclusion: neonatal hyperbilirubinemia predictors are Cord BILIRUBIN/ALBUMIN ratio , serum bilirubin and albumin.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41942054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background: Untreated acute pancreatitis can have high morbidity and mortality. It is a serious gastrointestinal emergency. Its incidence is approximately 51.0 % and it can cause both local and systemic problems. The diagnosis usually involves laboratory tests like amylase and lipase as well as an ultrasound exam. The ideal imaging test is a contrast-enhanced CT scan. This study used scoring systems based on laboratory and radiological investigations to determine the clinical progression and outcome. Methods : Patients who were diagnosed with acute pancreatitis and in whom computed tomography was done were included. From the imaging findings, the category and subcategory of acute pancreatitis and types of fluid collections were described in these patients using the revised Atlanta classification. BISAP score was calculated in all these patients. The clinical outcome assessed in these patients is the duration of stay in the hospital, mortality, presence of persistent organ failure, the occurrence of infection and need for intervention. Finally, the correlation between the Revised Atlanta classification and BISAP score was analyzed and compared with clinical outcomes. Results: The analysis of the correlation between Revised Atlanta classification severity grade and BISAP score, among the n=57 patients with mild acute pancreatitis n=56, had BISAP score less than 3 and only one had BISAP score greater or equal to three. Among the n=25 patients graded as moderately severe acute pancreatitis, n=20 cases had a BISAP score of less than 3 and n=5 had BISAP score greater than or equal to three. Among the n=08 patients graded as severe acute pancreatitis, n=3 had a BISAP score of less than 3 and n=5 had BISAP score greater than or equal to three. Conclusion: Standardizing nomenclature and facilitating proper documentation of a variety of imaging abnormalities in acute pancreatitis is made possible by incorporating the new Atlanta categorization system into daily practice. We can triage, predict, and treat patients with acute pancreatitis with greater precision by integrating the new Atlanta classification with BISAP clinical grading, significantly improving medical care.
{"title":"Assessment of Severity of Pancreatitis by Computerized Tomography Using Revised Atlanta Classification and Comparison with BISAP Clinical Scoring System","authors":"Srikanth Sagi, Keerthi Bharati","doi":"10.47799/pimr.1003.03","DOIUrl":"https://doi.org/10.47799/pimr.1003.03","url":null,"abstract":"Abstract\u0000 \u0000 Background: Untreated acute pancreatitis can have high morbidity and mortality. It is a serious gastrointestinal emergency. Its incidence is approximately 51.0 % and it can cause both local and systemic problems. The diagnosis usually involves laboratory tests like amylase and lipase as well as an ultrasound exam. The ideal imaging test is a contrast-enhanced CT scan. This study used scoring systems based on laboratory and radiological investigations to determine the clinical progression and outcome.\u0000 \u0000 Methods\u0000 : Patients who were diagnosed with acute pancreatitis and in whom computed tomography was done were included. From the imaging findings, the category and subcategory of acute pancreatitis and types of fluid collections were described in these patients using the revised Atlanta classification. BISAP score was calculated in all these patients. The clinical outcome assessed in these patients is the duration of stay in the hospital, mortality, presence of persistent organ failure, the occurrence of infection and need for intervention. Finally, the correlation between the Revised Atlanta classification and BISAP score was analyzed and compared with clinical outcomes.\u0000 \u0000 Results: The analysis of the correlation between Revised Atlanta classification severity grade and BISAP score, among the n=57 patients with mild acute pancreatitis n=56, had BISAP score less than 3 and only one had BISAP score greater or equal to three. Among the n=25 patients graded as moderately severe acute pancreatitis, n=20 cases had a BISAP score of less than 3 and n=5 had BISAP score greater than or equal to three. Among the n=08 patients graded as severe acute pancreatitis, n=3 had a BISAP score of less than 3 and n=5 had BISAP score greater than or equal to three.\u0000 \u0000 Conclusion: Standardizing nomenclature and facilitating proper documentation of a variety of imaging abnormalities in acute pancreatitis is made possible by incorporating the new Atlanta categorization system into daily practice. We can triage, predict, and treat patients with acute pancreatitis with greater precision by integrating the new Atlanta classification with BISAP clinical grading, significantly improving medical care.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43200537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ishrath Fatima Fatima, Swati N. Nagapurkar, Amreen Khan
Abstract Background: Grand multiparous pregnancies have been considered to be at higher risk of developing antenatal and perinatal complications like pre-eclampsia, gestational diabetes mellitus, anemia, antepartum hemorrhages, preterm labor, mal-presentation, mal-position and feto-pelvic disproportion This study was done to know the magnitude of grand multipara attending the tertiary care center with possible complications related to high parity. Objectives:To study the prevalence possible feto-maternal complications associated with grand multipara at rural setup. Methodology:Descriptive cross-sectional study conducted in medical college of rural area for 12 months. Grand multipara with 5 or more deliveries before current pregnancy coming for antenatal checkup and delivery were enrolled. Antenatal history was recorded till delivery and feto-maternal outcomes were noted. Results:Out of 1500 deliveries conducted during study period, 110 (7.5%) cases were grand multipara. Majority of them (79.5%) were Muslim and 80% were anaemic. 60% delivered with FTND, and 25.4% had emergency LSCS with one intrauterine death and a single breach delivery. Predominantly preeclampsia (23.6%) and malpresentation (14.5%) were diagnosed as antepartum complications. Almost one fifth of them had postpartum hemorrhage which was controlled with no mortality. 13 (11.8%) grand multipara women had still birth or early neonatal death, though fetal distress was observed in 37 cases. Conclusion: Grand multiparty is still a high-risk pregnancy associated with adverse maternal and fetal outcomes in our facility with multiple interrelated but mostly preventable causes.
{"title":"Study of magnitude of grand multiparty and its perinatal outcome in a tertiary hospital \u0000 of rural area in \u0000 Maharashtra","authors":"Ishrath Fatima Fatima, Swati N. Nagapurkar, Amreen Khan","doi":"10.47799/pimr.1003.15","DOIUrl":"https://doi.org/10.47799/pimr.1003.15","url":null,"abstract":"Abstract Background: Grand multiparous pregnancies have been considered to be at higher risk of developing antenatal and perinatal complications like pre-eclampsia, gestational diabetes mellitus, anemia, antepartum hemorrhages, preterm labor, mal-presentation, mal-position and feto-pelvic disproportion This study was done to know the magnitude of grand multipara attending the tertiary care center with possible complications related to high parity. Objectives:To study the prevalence possible feto-maternal complications associated with grand multipara at rural setup. Methodology:Descriptive cross-sectional study conducted in medical college of rural area for 12 months. Grand multipara with 5 or more deliveries before current pregnancy coming for antenatal checkup and delivery were enrolled. Antenatal history was recorded till delivery and feto-maternal outcomes were noted. Results:Out of 1500 deliveries conducted during study period, 110 (7.5%) cases were grand multipara. Majority of them (79.5%) were Muslim and 80% were anaemic. 60% delivered with FTND, and 25.4% had emergency LSCS with one intrauterine death and a single breach delivery. Predominantly preeclampsia (23.6%) and malpresentation (14.5%) were diagnosed as antepartum complications. Almost one fifth of them had postpartum hemorrhage which was controlled with no mortality. 13 (11.8%) grand multipara women had still birth or early neonatal death, though fetal distress was observed in 37 cases. Conclusion: Grand multiparty is still a high-risk pregnancy associated with adverse maternal and fetal outcomes in our facility with multiple interrelated but mostly preventable causes.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43985709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haritha Vissamsetti, K. V. Phani Madhavi, B. Madhavi
Abstract Background: The Information technology has revolutionized many changes throughout the society, and also in bringing up the economic growth of the country.IT professionals are prone to various job-related complaints and symptoms which can be reduced or eliminated by using proper ergonomics. The present study was carried out to study the prevalence of Musculoskeletal disorders among the Information technology (IT) professionals and to determine the factors associated with musculoskeletal problems. Objectives:1.To study the prevalence of Musculoskeletal disorders among the Information Technology (IT) professionals. 2. To determine the factors associated with Musculoskeletal disorders among IT Professionals. Methodology: A cross-sectional study was done among 400 Information technology professionals of selected IT companies of Visakhapatnam city using multistage sampling technique. Structured Interview schedule was taken to collect socio-demographic, personal and working details of employees. Standardised Nordic Musculoskeletal questionnaire was used to assess the work-related musculoskeletal symptoms in relation to various body regions during last 12 months and last 1 week. Results:The overall musculoskeletal disorders among IT professionals was 74% of which lower back (56.7%) is the most common body region affected in the last 12 months followed by neck (43%), shoulder (28.2%), wrist/hand (8.5%), elbow (5.7%), knee (4%) and ankle (3.7%). Conclusions: The study concludes that, prevalence of work-related health problems among IT professionals are of concern. Work related musculoskeletal problems were widely reported and it was observed that, individuals who have regular physical activity are less prone to Musculoskeletal disorders (MSD).
{"title":"A Cross Sectional Study Among Information Technology Professionals of Vishakhapattanam City to Study the Prevalence of Musculoskeletal Work Related Disorders","authors":"Haritha Vissamsetti, K. V. Phani Madhavi, B. Madhavi","doi":"10.47799/pimr.1003.06","DOIUrl":"https://doi.org/10.47799/pimr.1003.06","url":null,"abstract":"Abstract\u0000 \u0000 Background: The Information technology has revolutionized many changes throughout the society, and also in bringing up the economic growth of the country.IT professionals are prone to various job-related complaints and symptoms which can be reduced or eliminated by using proper ergonomics. The present study was carried out to study the prevalence of Musculoskeletal disorders among the Information technology (IT) professionals and to determine the factors associated with musculoskeletal problems.\u0000 \u0000 Objectives:1.To study the prevalence of Musculoskeletal disorders among the Information Technology (IT) professionals. 2. To determine the factors associated with Musculoskeletal disorders among IT Professionals.\u0000 \u0000 Methodology: A cross-sectional study was done among 400 Information technology professionals of selected IT companies of Visakhapatnam city using multistage sampling technique. Structured Interview schedule was taken to collect socio-demographic, personal and working details of employees. Standardised Nordic Musculoskeletal questionnaire was used to assess the work-related musculoskeletal symptoms in relation to various body regions during last 12 months and last 1 week. \u0000 \u0000 Results:The overall musculoskeletal disorders among IT professionals was 74% of which lower back (56.7%) is the most common body region affected in the last 12 months followed by neck (43%), shoulder (28.2%), wrist/hand (8.5%), elbow (5.7%), knee (4%) and ankle (3.7%).\u0000 \u0000 Conclusions: The study concludes that, prevalence of work-related health problems among IT professionals are of concern. Work related musculoskeletal problems were widely reported and it was observed that, individuals who have regular physical activity are less prone to Musculoskeletal disorders (MSD).","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42050698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sirish Aryasomayajula, Manimala Danda, Aswini Gude, suneetha Pyadi, Padmapriya Mamillapalli, K. Epari, Vahini Gudeli, Ramkrishna B. A.
Abstract Introduction: Hyperpigmentation is one of the most common reaction to inflammatory, benign and malignant lesions of the skin. These disorders comprise heterogeneous group of diseases of epidermal and dermal hyperpigmentation divided into various types according to etiology and pathology. Correct diagnosis of these hyperpigmented lesions is linked to histopathologic examination of skin biopsies with clinical correlation. Aim: To study the spectrum of hyperpigmented skin lesions with reference to age and sex distribution. Materials and Methods: This prospective cohort study was conducted at Department of Pathology, at Alluri Sitaramaraju Academy of Medical Sciences, Eluru, Andhra Pradesh, India, which included 80 patients who were clinically diagnosed with hyperpigmented skin lesions in all age groups from July 2014 to August 2016. Frequency and percentage statistics was used to present the results. Results: Out of 80 cases, 34 cases of inflammatory lesions, 23 cases of benign lesions and 23 cases of malignant lesions were reported. Among the post inflammatory lesions the majority were classical Lichen planus. Conclusion: Most common lesion was lichen planus and its variants with highest incidence in females and age group greater than 60 years. Histopathological diagnosis with clinical correlation aids in effective management of the patients.
{"title":"Clinicopathological profile of hyperpigment\u0000 ed skin lesions- A prospective \u0000 study","authors":"Sirish Aryasomayajula, Manimala Danda, Aswini Gude, suneetha Pyadi, Padmapriya Mamillapalli, K. Epari, Vahini Gudeli, Ramkrishna B. A.","doi":"10.47799/pimr.1003.14","DOIUrl":"https://doi.org/10.47799/pimr.1003.14","url":null,"abstract":"Abstract\u0000 \u0000 Introduction: Hyperpigmentation is one of the most common reaction to inflammatory, benign and malignant lesions of the skin. These disorders comprise heterogeneous group of diseases of epidermal and dermal hyperpigmentation divided into various types according to etiology and pathology. Correct diagnosis of these hyperpigmented lesions is linked to histopathologic examination of skin biopsies with clinical correlation.\u0000 \u0000 Aim: To study the spectrum of hyperpigmented skin lesions with reference to age and sex distribution.\u0000 \u0000 Materials and Methods: This prospective cohort study was conducted at Department of Pathology, at Alluri Sitaramaraju Academy of Medical Sciences, Eluru, Andhra Pradesh, India, which included 80 patients who were clinically diagnosed with hyperpigmented skin lesions in all age groups from July 2014 to August 2016. Frequency and percentage statistics was used to present the results. \u0000 \u0000 Results: Out of 80 cases, 34 cases of inflammatory lesions, 23 cases of benign lesions and 23 cases of malignant lesions were reported. Among the post inflammatory lesions the majority were classical Lichen planus. Conclusion: Most common lesion was lichen planus and its variants with highest incidence in females and age group greater than 60 years. Histopathological diagnosis with clinical correlation aids in effective management of the patients.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46433018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Shukla, P. Sharma, S. Sharma, Sangishetti Vijay Prasad, Sumita Sharma, N. Garg
Abstract Introduction: Osteoarthritis (OA) is a progressive, degenerative disease that leads to joint pain, tenderness, stiffness, locking, effusion, reduced motion, swelling, crepitus, and disability. The pain in OA is the most significant clinical feature and impacts function, mobility, quality of life, and the reason for medical advice. Methods: Fifty individuals with primary knee OA in the age range of 45–90 years were chosen at random for the research (N=50). The American College of Rheumatology's diagnostic criteria were employed to diagnose osteoarthritis, and a visual analogue scale was utilized to score the severity of pain. Knee OA was graded using the Kellgren-Lawrence (K-L) radiographic assessment method. The antioxidant levels of superoxide dismutase in the synovial fluid were measured by using a spectrophotometric assay. Results: Grades 1, 2, 3, and 4 have SOD activity values of 1.43±0.55, 1.44±0.72, 0.92±0.52, and 0.87 ±0.52 U/ml, respectively, in synovial fluid. Synovial fluid SOD activity was higher in grades 1 & 2 of KOA as compared to grades 3 &4 and the difference was statistically significant (p<0.05). Conclusions: There was a link between K-L grade and synovial antioxidant activity level. In the late stages of knee osteoarthritis, the antioxidant enzyme (SOD) activity was reduced.According to the results of this study, regular antioxidant supplementation to early osteoarthritis patients may delay disease progression by improving the antioxidant status of the knee, which neutralises free radicals and thus prevents cartilage damage.
{"title":"Does Antioxidant Superoxide Dismutase levels Decline with Advanced primary Knee Osteoarthritis in Synovial Fluid ? A Pilot Study","authors":"J. Shukla, P. Sharma, S. Sharma, Sangishetti Vijay Prasad, Sumita Sharma, N. Garg","doi":"10.47799/pimr.1003.10","DOIUrl":"https://doi.org/10.47799/pimr.1003.10","url":null,"abstract":"Abstract\u0000 \u0000 Introduction: Osteoarthritis (OA) is a progressive, degenerative disease that leads to joint pain, tenderness, stiffness, locking, effusion, reduced motion, swelling, crepitus, and disability. The pain in OA is the most significant clinical feature and impacts function, mobility, quality of life, and the reason for medical advice. Methods: Fifty individuals with primary knee OA in the age range of 45–90 years were chosen at random for the research (N=50). The American College of Rheumatology's diagnostic criteria were employed to diagnose osteoarthritis, and a visual analogue scale was utilized to score the severity of pain. Knee OA was graded using the Kellgren-Lawrence (K-L) radiographic assessment method. The antioxidant levels of superoxide dismutase in the synovial fluid were measured by using a spectrophotometric assay. Results: Grades 1, 2, 3, and 4 have SOD activity values of 1.43±0.55, 1.44±0.72, 0.92±0.52, and 0.87 ±0.52 U/ml, respectively, in synovial fluid. Synovial fluid SOD activity was higher in grades 1 & 2 of KOA as compared to grades 3 &4 and the difference was statistically significant (p<0.05). Conclusions: There was a link between K-L grade and synovial antioxidant activity level. In the late stages of knee osteoarthritis, the antioxidant enzyme (SOD) activity was reduced.According to the results of this study, regular antioxidant supplementation to early osteoarthritis patients may delay disease progression by improving the antioxidant status of the knee, which neutralises free radicals and thus prevents cartilage damage.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43726360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rising trends in Anti Microbial Resistance","authors":"R. Kasturi, A. Rathod, Abhilasha Katoch","doi":"10.47799/pimr.1003.01","DOIUrl":"https://doi.org/10.47799/pimr.1003.01","url":null,"abstract":"","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46918777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jayashree Pandya, Riya Ramteke, Sudatta B Waghmare
Abstract Background:Necrotising fasciitis(NF) is one of the most fulminant infection of skin and soft tissue. It is a fatal rapidly progressing disease causing Multi organ Dysfunction syndrome (MODS), septic shock & death if not identified early & treated accordingly. The aim is to study risk factors associated with NF and predictors of outcome. Settings & design: Prospective observational study in a single tertiary care center. Materials and Methods:Prospective analysis of patients with NF from March 2018 – August 2019 was done. The known risk factors were studied. Results: A Total 120 patients were reviewed. Out of which 81 (67.5%) were males and 39 (32.5%) were females. The mortality rate in our study was 14.16%. It was significantly high in patients with CRF (p 0.045), HIV (p <0.001), Diabetes with other risk factors (p 0.003),BSA > 10% (p <0.01), Type 3 culture (0.027),LRINEC score >6 (p 0.015). Conclusion:NF in patients with known risk factors progresses rapidly, so aggressive treatment should be given at the earliest. Early identification & prompt intervention is the key for better survival outcome in NF.
{"title":"Risk Factors and Predictors of Outcome for Necrotising Fasciitis","authors":"Jayashree Pandya, Riya Ramteke, Sudatta B Waghmare","doi":"10.47799/pimr.1002.14","DOIUrl":"https://doi.org/10.47799/pimr.1002.14","url":null,"abstract":"Abstract\u0000 \u0000 Background:Necrotising fasciitis(NF) is one of the most fulminant infection of skin and soft tissue. It is a fatal rapidly progressing disease causing Multi organ Dysfunction syndrome (MODS), septic shock & death if not identified early & treated accordingly. The aim is to study risk factors associated with NF and predictors of outcome.\u0000 \u0000 Settings & design: Prospective observational study in a single tertiary care center.\u0000 \u0000 Materials and Methods:Prospective analysis of patients with NF from March 2018 – August 2019 was done. The known risk factors were studied.\u0000 \u0000 Results: A Total 120 patients were reviewed. Out of which 81 (67.5%) were males and 39 (32.5%) were females. The mortality rate in our study was 14.16%. It was significantly high in patients with CRF (p 0.045), HIV (p <0.001), Diabetes with other risk factors (p 0.003),BSA > 10% (p <0.01), Type 3 culture (0.027),LRINEC score >6 (p 0.015).\u0000 \u0000 Conclusion:NF in patients with known risk factors progresses rapidly, so aggressive treatment should be given at the earliest. Early identification & prompt intervention is the key for better survival outcome in NF.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45635751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: An estimated 9.9 million people fell ill with tuberculosis globally in 2020 with India and China contributing a major percentage to the burden of TB. India is grouped under high TB, high HIV associated TB and MDR TB burden countries and 1.24 lakh fell ill with drug resistant TB out of which 56000 were started on second line treatment in 2020. Annually India accounts for 27% of missing TB cases. Diagnosis: The major forms of drug resistant TB that are of clinical importance are INH monoresistant TB, multidrug resistant TB, pre- XDR TB and XDR TB.WHO approved newer molecular tests for MTB detection and drug susceptibility tests. Treatment: Few newer drugs and few previously used drugs are showing promise when used in combination which have come up in recent years. Bedaquiline based regimens are showing improved cure rates. Conclusion: Guidelines based regimens should be strictly adhered to by both public and private TB case treating physicians.
{"title":"Review on Drug Resistant Tuberculosis","authors":"Nagender Prasad Chenimilla, Pravinya Pittala, Ramulu Madire","doi":"10.47799/pimr.1002.02","DOIUrl":"https://doi.org/10.47799/pimr.1002.02","url":null,"abstract":"Abstract\u0000 Introduction: An estimated 9.9 million people fell ill with tuberculosis globally in 2020 with India and China contributing a major percentage to the burden of TB. India is grouped under high TB, high HIV associated TB and MDR TB burden countries and 1.24 lakh fell ill with drug resistant TB out of which 56000 were started on second line treatment in 2020. Annually India accounts for 27% of missing TB cases. Diagnosis: The major forms of drug resistant TB that are of clinical importance are INH monoresistant TB, multidrug resistant TB, pre- XDR TB and XDR TB.WHO approved newer molecular tests for MTB detection and drug susceptibility tests. Treatment: Few newer drugs and few previously used drugs are showing promise when used in combination which have come up in recent years. Bedaquiline based regimens are showing improved cure rates. Conclusion: Guidelines based regimens should be strictly adhered to by both public and private TB case treating physicians.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44225206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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