Abstract Aim:The aim of the current study is to evaluate anti-anxiety and potentiating effect of Thiocolchicoside in animal models of anxiety. Methodology: A total of 24 (n=24) Swiss albino mice were procured, and they were divided into four groups of six mice in each. First group of mice (control) received 10 ml/kg-Normal Saline, second group (standard) received 2.0 mg/kg-Diazepam, test-1 received 1 mg/kg-Thiocolchicoside and test-2 received Thiocolchicoside (1mg/kg) + Diazepam (2mg/kg) for seven days per orally. All the mice were evaluated for anti-anxiety activity by Elevated Plus Maze (EPM) 60 minutes after the oral drug administration of drugs on day 1, 3 and 7 and later after a washout period of one month, same four groups of mice were screened by Light and Dark Arena (LDA) model after receiving respective drugs. Results: One-way ANOVA followed by Tukey’s Kramer test were applied for inter group comparison and correlation test for intra-group comparison. Results are expressed in mean ± SEM. In EPM, time spent in open arm for the control, standard, test- 1 and test-2 were 64.5±25.81, 128.33±17.6, 138±10.56 and 168.33±22.35 seconds respectively. There is statistically significant difference between standard (P=0.05), test-1 (P=0.05) and test-2 (P=0.03) when compared with control group. Similarly, time spent in closed arm for the control, standard, test-1 and test-2 were 238.83±20.41, 171.67± 17.6, 162±10.56 and 131.67±22.35 seconds respectively. In this, test-2 is statistically significant from the control group (P=0.05). The number of entries in the open arm for the control group, standard group, test-1 and test-2 were 3.5±1.64, 13.17±7.44, 21 ± 4.05 and 13.33 ± 2.16 respectively. There is statistically significant difference between standard (P=0.03), test-1 (P=0.02) and test-2 (P=0.03) with control. Similarly, number of entries to closed arm for the control, standard, test-1 and test-2 were 9.5±3.62, 16.33 ± 5.65, 16.33 ± 4.23 and 8.17 ± 1.72 respectively. The values obtained for the standard, test-1 and test-2 were not statistically significant (P=0.8). In LDA, time spent in light arena for the control, standard, test-1 and test-2 were 106.83±18.21, 163.5±21.66, 105.33 ± 11.57 and 125.17 ± 16.35 seconds respectively. Statistically significant difference between the control and the standard group (P=0.05) is noted. Time spent in dark arena for the control, standard, test-1 and test-2 were 193.17±18.21, 136.5±11.66, 194.67±15.57 and 174.83±16.35 seconds respectively. Here only standard group is statistically significant when compared with control (P=0.05). The number of entries in the light arena for the control, standard, test-1 and test-2 were 11.67 ± 1.37, 13.17 ± 2.48, 12 ± 2.61 and 11.67 ± 1.03 respectively. The number of entries in the dark arena for the control, standard, test-1 and test-2 were 12.17 ± 1.47, 13.17 ± 2.93, 11.83 ± 2.23 and 11 ± 0.89 respectively. With regard to number of entries in the light and dark arena t
摘要目的：本研究的目的是评估Thiocolchicoside在焦虑动物模型中的抗焦虑和增强作用。方法：共获得24只（n=24）瑞士白化病小鼠，将其分为四组，每组6只。第一组小鼠（对照组）接受10ml/kg生理盐水，第二组（标准组）接受2.0mg/kg地西泮，试验-1接受1mg/kg硫代秋水仙糖苷，试验-2接受1mg/kg Thiocolchicoside+2mg/kg地西泮口服7天。在第1天、第3天和第7天口服药物给药60分钟后，以及在一个月的冲洗期后，通过Elevated Plus Maze（EPM）对所有小鼠的抗焦虑活性进行评估，同样的四组小鼠在接受各自的药物后通过Light and Dark Arena（LDA）模型进行筛选。结果：单因素方差分析和Tukey’s Kramer检验用于组间比较，相关检验用于组内比较。结果用平均值±SEM表示。在EPM中，对照组、标准组、试验-1和试验-2在开放臂上花费的时间分别为64.5±25.81、128.33±17.6、138±10.56和168.33±22.35秒。与对照组相比，标准组（P=0.05）、试验-1组（P=0.005）和试验-2组（P=0.03）之间存在统计学显著差异。同样，对照组、标准组、试验-1和试验-2在闭合臂上花费的时间分别为238.83±20.41、171.67±17.6、162±10.56和131.67±22.35秒。其中，试验-2与对照组相比具有统计学意义（P=0.05）。对照组、标准组、试验-1和试验-2的开放臂条目数分别为3.5±1.64、13.17±7.44、21±4.05和13.33±2.16。标准组（P=0.03）、试验-1组（P=0.02）和试验-2组（P=0.003）与对照组之间存在统计学显著差异。同样，对照组、标准组、试验-1和试验-2进入闭合臂的次数分别为9.5±3.62、16.33±5.65、16.33士4.23和8.17±1.72。在LDA中，对照组、标准组、试验组1和试验组2在光场中花费的时间分别为106.83±18.21、163.5±21.66、105.33±11.57和125.17±16.35秒。对照组和标准组之间存在统计学上的显著差异（P=0.05）。对照组、标准组、试验-1和试验-2在黑暗环境中的时间分别为193.17±18.21、136.5±11.66、194.67±15.57和174.83±16.35秒。与对照组相比，只有标准组具有统计学意义（P=0.05）。对照组、标准组、测试-1和测试-2在光场的进入次数分别为11.67±1.37、13.17±2.48、12±2.61和11.67±1.03。对照组、标准组、试验-1和试验-2在黑暗区域的进入次数分别为12.17±1.47、13.17±2.93、11.83±2.23和11±0.89。就进入光明和黑暗领域的次数而言，两组之间没有统计学上的显著差异（P>0.05）。结论：研究结果清楚地表明，在EPM和LDA模型中，Thiocolchicoside（1mg/kg）与地西泮联合使用具有抗焦虑和额外增强作用。
{"title":"Potential role of Thiocolchicoside in anxiety disorder: A pre-clinical study","authors":"K. Gourav, Prabhakar Adake, R. Nayak","doi":"10.47799/pimr.0903.11","DOIUrl":"https://doi.org/10.47799/pimr.0903.11","url":null,"abstract":"Abstract\u0000 \u0000 Aim:The aim of the current study is to evaluate anti-anxiety and potentiating effect of Thiocolchicoside in animal models of anxiety.\u0000 \u0000 Methodology: A total of 24 (n=24) Swiss albino mice were procured, and they were divided into four groups of six mice in each. First group of mice (control) received 10 ml/kg-Normal Saline, second group (standard) received 2.0 mg/kg-Diazepam, test-1 received 1 mg/kg-Thiocolchicoside and test-2 received Thiocolchicoside (1mg/kg) + Diazepam (2mg/kg) for seven days per orally. All the mice were evaluated for anti-anxiety activity by Elevated Plus Maze (EPM) 60 minutes after the oral drug administration of drugs on day 1, 3 and 7 and later after a washout period of one month, same four groups of mice were screened by Light and Dark Arena (LDA) model after receiving respective drugs.\u0000 \u0000 Results: One-way ANOVA followed by Tukey’s Kramer test were applied for inter group comparison and correlation test for intra-group comparison. Results are expressed in mean ± SEM. In EPM, time spent in open arm for the control, standard, test- 1 and test-2 were 64.5±25.81, 128.33±17.6, 138±10.56 and 168.33±22.35 seconds respectively. There is statistically significant difference between standard (P=0.05), test-1 (P=0.05) and test-2 (P=0.03) when compared with control group. Similarly, time spent in closed arm for the control, standard, test-1 and test-2 were 238.83±20.41, 171.67± 17.6, 162±10.56 and 131.67±22.35 seconds respectively. In this, test-2 is statistically significant from the control group (P=0.05). The number of entries in the open arm for the control group, standard group, test-1 and test-2 were 3.5±1.64, 13.17±7.44, 21 ± 4.05 and 13.33 ± 2.16\u0000 respectively. There is statistically significant difference between standard (P=0.03), test-1 (P=0.02) and test-2 (P=0.03) with control. Similarly, number of entries to closed arm for the control, standard, test-1 and test-2 were 9.5±3.62, 16.33 ± 5.65, 16.33 ± 4.23 and 8.17 ± 1.72 respectively. The values obtained for the standard, test-1 and test-2 were not statistically significant (P=0.8). In LDA, time spent in light arena for the control, standard, test-1 and test-2 were 106.83±18.21, 163.5±21.66, 105.33 ± 11.57 and 125.17 ± 16.35 seconds respectively. Statistically significant difference between the control and the standard group (P=0.05) is noted. Time spent in dark arena for the control, standard, test-1 and test-2 were 193.17±18.21, 136.5±11.66, 194.67±15.57 and 174.83±16.35 seconds respectively. Here only standard group is statistically significant when compared with control (P=0.05). The number of entries in the light arena for the control, standard, test-1 and test-2 were 11.67 ± 1.37, 13.17 ± 2.48, 12 ± 2.61 and 11.67 ± 1.03 respectively. The number of entries in the dark arena for the control, standard, test-1 and test-2 were 12.17 ± 1.47, 13.17 ± 2.93, 11.83 ± 2.23 and 11 ± 0.89 respectively. With regard to number of entries in the light and dark arena t","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41832097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Supracondylar humerus fracture (SCHF) is frequently encountered in pediatric age group and nearly three fourth of all upper extremity fractures. Most commonly used technique for surgical treatment in the displaced SCHF in children is closed reduction and stabilization with percutaneous pins. Aim: This retrospective study was conducted to find out the outcome and safety of percutaneous pinning techniques which includes lateral pinning and cross pinning in terms of functional and radiological outcome in the management of displaced supracondylar humerus fractures in children and to see the associated complications with this method of fixation. Materials & Methods: This retrospective study comprising of 40 cases of displaced supracondylar humerus fracture, treated with lateral or cross pinning was carried out at Orthopedics Department, Gujarat Adani Institute of Medical Sciences and G.K General Hospital, Bhuj from July 2019 to june2020. The inclusion criteria were: a) Gartland extension type II, III, b) age below 12 years, c) presented to OPD/Emergency within 48 hours of injury, d) closed and gustilo grade I open fractures, Patients with: a) extension Type I of fractures, b) flexion type injuries, c) except Gustilo grade 1 open fracture d) age more than 12 year e) pervious history of fractures or nerve injury around the elbow, were excluded from the study. Results: Out of the 40 patients, 25 (62.5%) were male and 15(37.5%) were female. The children were aged 2 years to 12 years with a median age of 7.67 years. There were 19 left sided and 21 right-sided fractures. 29 children had an injury while playing and 11 had a fall from a height. functional results in our study were 67.5% of cases had excellent results, 25% had good results, 5% had a fair result and 2.5% had a poor result. 75% of cases had excellent cosmetic results were 17.5% of cases had good results, 5% had fair result and only one case had a poor result. Conclusion: In our study, we found that anatomical reduction and intra- operative stability will dictate the type of configuration to be used in SCHF
{"title":"Is Percutaneous Fixation Necessary & Adequate For Displaced Supracondylar Fractures of Humerus in Children? - An\u0000Institutional Study","authors":"V. Pushkarna, V. Patel","doi":"10.47799/pimr.0902.14","DOIUrl":"https://doi.org/10.47799/pimr.0902.14","url":null,"abstract":"Supracondylar humerus fracture (SCHF) is frequently\u0000encountered in pediatric age group and nearly three fourth of\u0000all upper extremity fractures. Most commonly used technique\u0000for surgical treatment in the displaced SCHF in children is closed\u0000reduction and stabilization with percutaneous pins.\u0000Aim: This retrospective study was conducted to find out the\u0000outcome and safety of percutaneous pinning techniques which\u0000includes lateral pinning and cross pinning in terms of functional\u0000and radiological outcome in the management of displaced\u0000supracondylar humerus fractures in children and to see the\u0000associated complications with this method of fixation.\u0000Materials & Methods: This retrospective study comprising of\u000040 cases of displaced supracondylar humerus fracture, treated\u0000with lateral or cross pinning was carried out at Orthopedics\u0000Department, Gujarat Adani Institute of Medical Sciences and\u0000G.K General Hospital, Bhuj from July 2019 to june2020. The\u0000inclusion criteria were: a) Gartland extension type II, III, b) age\u0000below 12 years, c) presented to OPD/Emergency within 48\u0000hours of injury, d) closed and gustilo grade I open fractures,\u0000Patients with: a) extension Type I of fractures, b) flexion type\u0000injuries, c) except Gustilo grade 1 open fracture d) age more\u0000than 12 year e) pervious history of fractures or nerve injury\u0000around the elbow, were excluded from the study.\u0000Results: Out of the 40 patients, 25 (62.5%) were male and\u000015(37.5%) were female. The children were aged 2 years to 12\u0000years with a median age of 7.67 years. There were 19 left\u0000sided and 21 right-sided fractures. 29 children had an injury\u0000while playing and 11 had a fall from a height. functional results\u0000in our study were 67.5% of cases had excellent results, 25%\u0000had good results, 5% had a fair result and 2.5% had a poor\u0000result. 75% of cases had excellent cosmetic results were 17.5%\u0000of cases had good results, 5% had fair result and only one case\u0000had a poor result.\u0000Conclusion: In our study, we found that anatomical reduction\u0000and intra- operative stability will dictate the type of\u0000configuration to be used in SCHF","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49477747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Chronic venous ulceration of the leg is a common presentation in surgical clinics. Although, the majority of ulcers can be healed by simple compression. Some chronic ulcers with venous competencies require correction surgeries. We in the current study tried to study the role of Cockett and Dodd's operation of subfascial ligation of below-knee perforator veins in the treatment of varicose veins of the lower limbs. Methods: This cross-sectional study was done in the Department of General Surgery, Prathima Institute of Medical Sciences, Naganoor, Karimnagar. N=40cases of varicosities of the lower limbs with perforatorincompetence with or without saphenofemoral incompetence. The patients were treated with perforator ligationalone with the Cockett and Dodd method or in combination with the stripping procedure. Results: The clinical classification shows C5 healed venous ulcers and C6 active venous ulcers. 64% of cases belonged to these two categories and no case of C1 was found in our study. Perforator incompetence only was found in n=25 cases where perforator ligation alone was done given in table 4. In n=15 cases, perforator ligation and stripping with or without ligation of sphenopopliteal junction was done. The minimal mean duration of stay was 5.5 days the maximal mean duration of stay was 8.0 days. Conclusion: Open subfascial perforator ligation by Cockett and Dodd's procedure is a good procedure in the treatment of primary varicose veins with perforator incompetence. The rates of complications can be largely reduced by careful patient selection and skill full operative techniques. Follow-up of patients must be done at intervals for the development of new incompetent perforating veins and varicosities which may lead to the recurrence of ulcer formation.
{"title":"Surgical Treatment of Incompetent Perforator Veins by\u0000Subfascial Ligation","authors":"C. Goud","doi":"10.47799/pimr.0902.12","DOIUrl":"https://doi.org/10.47799/pimr.0902.12","url":null,"abstract":"Background: Chronic venous ulceration of the leg is a common\u0000presentation in surgical clinics. Although, the majority of ulcers\u0000can be healed by simple compression. Some chronic ulcers with\u0000venous competencies require correction surgeries. We in the\u0000current study tried to study the role of Cockett and Dodd's\u0000operation of subfascial ligation of below-knee perforator veins\u0000in the treatment of varicose veins of the lower limbs.\u0000Methods: This cross-sectional study was done in the\u0000Department of General Surgery, Prathima Institute of Medical\u0000Sciences, Naganoor, Karimnagar. N=40cases of varicosities of\u0000the lower limbs with perforatorincompetence with or without\u0000saphenofemoral incompetence. The patients were treated with\u0000perforator ligationalone with the Cockett and Dodd method\u0000or in combination with the stripping procedure.\u0000Results: The clinical classification shows C5 healed venous\u0000ulcers and C6 active venous ulcers. 64% of cases belonged to\u0000these two categories and no case of C1 was found in our study.\u0000Perforator incompetence only was found in n=25 cases where\u0000perforator ligation alone was done given in table 4. In n=15\u0000cases, perforator ligation and stripping with or without ligation\u0000of sphenopopliteal junction was done. The minimal mean\u0000duration of stay was 5.5 days the maximal mean duration of\u0000stay was 8.0 days.\u0000Conclusion: Open subfascial perforator ligation by Cockett and\u0000Dodd's procedure is a good procedure in the treatment of\u0000primary varicose veins with perforator incompetence. The rates\u0000of complications can be largely reduced by careful patient\u0000selection and skill full operative techniques. Follow-up of\u0000patients must be done at intervals for the development of new\u0000incompetent perforating veins and varicosities which may lead\u0000to the recurrence of ulcer formation.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48350157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maddela Soumya, Sk. Khasim, R. Kasturi, Srinivas Kumar Arramraju, N. Mudgalkar, A. Baviskar
Introduction: Ibutilide is a class 3 antiarrythmic agent that is used infrequently. There are few studies on its usage, especially among Indians. Materials & Methods: A retrospective study was conducted on patients in a tertiary care unit who had recently developed atrial fibrillation and were given the normal dose of ibutilide. During the study period, data was gathered from medical records. Results: During the study period, ibutilide was given to a total of 40 patients who met the inclusion criteria. The majority of the participants were under 60 years old and had only been in atrial fibrillation for less than 24 hours. In 70% of cases, atrial fibrillation could be successfully terminated with only a small risk of adverse events. Conclusion: Ibutilide is a safe and effective treatment for people who have recent onset atrial fibrillation.
{"title":"Efficacy of Ibutilide for Terminating Recent Onset Atrial Fibrillation- A Single Centre Study","authors":"Maddela Soumya, Sk. Khasim, R. Kasturi, Srinivas Kumar Arramraju, N. Mudgalkar, A. Baviskar","doi":"10.47799/pimr.0902.16","DOIUrl":"https://doi.org/10.47799/pimr.0902.16","url":null,"abstract":"Introduction:\u0000Ibutilide is a class 3 antiarrythmic agent that is used\u0000infrequently. There are few studies on its usage, especially\u0000among Indians.\u0000Materials & Methods: A retrospective study was conducted\u0000on patients in a tertiary care unit who had recently developed\u0000atrial fibrillation and were given the normal dose of ibutilide.\u0000During the study period, data was gathered from medical\u0000records.\u0000Results: During the study period, ibutilide was given to a total\u0000of 40 patients who met the inclusion criteria. The majority of\u0000the participants were under 60 years old and had only been in\u0000atrial fibrillation for less than 24 hours. In 70% of cases, atrial\u0000fibrillation could be successfully terminated with only a small\u0000risk of adverse events.\u0000Conclusion: Ibutilide is a safe and effective treatment for\u0000people who have recent onset atrial fibrillation.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41853136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Acute poisoning represents a real health threat in the world. It is a common cause of admission to emergency department and in intensive care unit. Periodic clinical and epidemiological studies are required to understand the pattern of poisoning. This study aims to analyze epidemiological aspect, clinical profile, and outcome of acute poisoning in a tertiary care hospital. Material and Methods: A cross sectional study was conducted at Government Medical College Hospital, Kota, Rajasthan. 102 admitted patients were taken for study from January 2020 to August 2020. Epidemiological variables age, sex, type of poison, mode of exposure, clinical presentation and outcome were studied. Results: The median age was 30.23 years with a male predominance (54.9%). The circumstances of poisoning were suicidal, accidental and unknown in 88.2%, 9.8%, and 1.96% respectively. Ingestion was the major route of exposure (98%) followed by inhalation (1.96%). The majority 33(32.4%) of cases were of Organophosphorus poisoning followed by 17(16.7%) cases of Rodenticide poisoning. The main symptoms were nausea and vomiting in 90(88.2%) cases. Convulsions were noted in 3(2.9%) patients. Gastric lavage was done for 92(90.19%). 8 patients (7.84%) were needed mechanical ventilation. 7 patients (6.86%) were needed vasoactive drugs. The rate of mortality was 8.82%. The aluminium phosphide poisoning was responsible for 44.4% deaths. Conclusion: Study revealed the high mortality associated with acute poisoning. Appropriate approach towards poisoning at tertiary care center and prevention remains the best strategy for reducing morbidity and mortality.
{"title":"An Epidemiological Study of Acute Poisoning In a Tertiary\u0000Care Centre","authors":"P. Jain, Kamalesh Katara, S. Jelia","doi":"10.47799/pimr.0902.08","DOIUrl":"https://doi.org/10.47799/pimr.0902.08","url":null,"abstract":"Introduction: Acute poisoning represents a real health threat\u0000in the world. It is a common cause of admission to emergency\u0000department and in intensive care unit. Periodic clinical and\u0000epidemiological studies are required to understand the pattern\u0000of poisoning. This study aims to analyze epidemiological aspect,\u0000clinical profile, and outcome of acute poisoning in a tertiary\u0000care hospital.\u0000Material and Methods: A cross sectional study was conducted\u0000at Government Medical College Hospital, Kota, Rajasthan. 102\u0000admitted patients were taken for study from January 2020 to\u0000August 2020. Epidemiological variables age, sex, type of poison,\u0000mode of exposure, clinical presentation and outcome were\u0000studied.\u0000Results: The median age was 30.23 years with a male\u0000predominance (54.9%). The circumstances of poisoning were\u0000suicidal, accidental and unknown in 88.2%, 9.8%, and 1.96%\u0000respectively. Ingestion was the major route of exposure (98%)\u0000followed by inhalation (1.96%). The majority 33(32.4%) of cases\u0000were of Organophosphorus poisoning followed by 17(16.7%)\u0000cases of Rodenticide poisoning. The main symptoms were\u0000nausea and vomiting in 90(88.2%) cases. Convulsions were\u0000noted in 3(2.9%) patients. Gastric lavage was done for\u000092(90.19%). 8 patients (7.84%) were needed mechanical\u0000ventilation. 7 patients (6.86%) were needed vasoactive drugs.\u0000The rate of mortality was 8.82%. The aluminium phosphide\u0000poisoning was responsible for 44.4% deaths.\u0000Conclusion: Study revealed the high mortality associated with\u0000acute poisoning. Appropriate approach towards poisoning at\u0000tertiary care center and prevention remains the best strategy\u0000for reducing morbidity and mortality.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48516990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
INTRODUCTION An internship orientation program is conducted in most of the medical colleges before the beginning of internship program to facilitate the transition between medical student and intern. The present study was initiated to assess the preparedness of interns for the internship program and identifying the areas that require additional training and education. MATERIALS AND METHODS A cross sectional study was carried out among 2014 batch interns of Malla Reddy Medical College for Women, Suraram, Hyderabad. Hard copies of the study questionnaire prepared and validated by expert panel was administered to the interns before and after the two-day internship orientation program. The outcomes were measured on 5-point quantitative scale. The raw scores obtained by each student were converted to percentages.The scores less than or equal to 49% were considered low, the scores between 50% to 70% were considered as average and scores above 71% were considered high with respect to level of preparedness for internship. Two open ended questions were asked – additional topics to be included in the program and other suggestions. RESULTS A total of 110 students completed the study. Only 2% of the interns were highly prepared for hospital practice before the orientation program while this number increased to 78% after the program. Interns expressed their desire to learn new topics like basic first aid to minor injuries, management of trauma cases and Road Traffic Accidents and handling of medical emergencies during the orientation program. They also suggested that there should more focus on practical demonstrations and hands on training in skill lab during this program. CONCLUSION here is significant improvement in the preparedness of interns after the orientation program indicated the program helped to boost the confidence of the interns for hospital practice.
{"title":"Preparedness for Internship: A Survey of New Interns at a\u0000Tertiary Care Hospital, Telangana","authors":"Padmavathy V, Kranti Tekulapally","doi":"10.47799/pimr.0902.06","DOIUrl":"https://doi.org/10.47799/pimr.0902.06","url":null,"abstract":"INTRODUCTION\u0000An internship orientation program is conducted in most of the\u0000medical colleges before the beginning of internship program\u0000to facilitate the transition between medical student and intern.\u0000The present study was initiated to assess the preparedness of\u0000interns for the internship program and identifying the areas\u0000that require additional training and education.\u0000MATERIALS AND METHODS\u0000A cross sectional study was carried out among 2014 batch\u0000interns of Malla Reddy Medical College for Women, Suraram,\u0000Hyderabad. Hard copies of the study questionnaire prepared\u0000and validated by expert panel was administered to the interns\u0000before and after the two-day internship orientation program.\u0000The outcomes were measured on 5-point quantitative scale.\u0000The raw scores obtained by each student were converted to\u0000percentages.The scores less than or equal to 49% were\u0000considered low, the scores between 50% to 70% were\u0000considered as average and scores above 71% were considered\u0000high with respect to level of preparedness for internship. Two\u0000open ended questions were asked – additional topics to be\u0000included in the program and other suggestions.\u0000RESULTS\u0000A total of 110 students completed the study. Only 2% of the\u0000interns were highly prepared for hospital practice before the\u0000orientation program while this number increased to 78% after\u0000the program. Interns expressed their desire to learn new topics\u0000like basic first aid to minor injuries, management of trauma\u0000cases and Road Traffic Accidents and handling of medical\u0000emergencies during the orientation program. They also\u0000suggested that there should more focus on practical\u0000demonstrations and hands on training in skill lab during this\u0000program.\u0000CONCLUSION\u0000here is significant improvement in the preparedness of interns\u0000after the orientation program indicated the program helped\u0000to boost the confidence of the interns for hospital practice.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45856680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Laparoscopic cholecystectomy is gaining popularity for the surgical treatment of gallbladder diseases. The technique has advantages of safe surgery, minimal complications, lower duration of hospital stay, and early return to normal activities. We in the current study tried to evaluate the outcomes of laparoscopic cholecystectomies done in our tertiary care teaching hospital. Methods: Based on the inclusion and exclusion criteria n=40 cases were identified and treated with laparoscopic cholecystectomy. A complete history which included the pasthistory, family history, socioeconomic status, nature of symptoms, diet history was obtained. All the patients underwent a complete clinical examination. The investigations carried out were complete blood picture, bleeding time, clotting time, ECG, LFT, KFT, FBS, blood groups, chest x-ray, and Ultrasound scan of the abdomen. All cases were operated as per the standard procedures. Results: The most common sign recorded in the cases was pain in right hypochondrium. Out of n=40 cases, 95% were present with pain 5% was without pain. Clinical jaundice was found in 10% of cases and tenderness was found on examination in 95% of cases. USG showed the presence of multiple stones was in 76% of cases, thickening of the gall bladder was in 80% cases and presence of mass was detected in 8% of cases. The follow-up period was 3 months in which no complications were reported. Conclusion: The study found that most of the cases of cholelithiasis now occurring across the spectrum of different ages. The diagnosis has now become easy with the presence of ultrasonography which has sensitivity and specificity. The motto of safe surgery, low morbidity, and early back to work is best done with laparoscopic cholecystectomy.
{"title":"A Clinical Study on Laparoscopic Cholecystectomy in a Tertiary Care\u0000Teaching Hospital","authors":"Arun Katari, R. M.","doi":"10.47799/pimr.0902.04","DOIUrl":"https://doi.org/10.47799/pimr.0902.04","url":null,"abstract":"Background: Laparoscopic cholecystectomy is gaining\u0000popularity for the surgical treatment of gallbladder diseases.\u0000The technique has advantages of safe surgery, minimal\u0000complications, lower duration of hospital stay, and early return\u0000to normal activities. We in the current study tried to evaluate\u0000the outcomes of laparoscopic cholecystectomies done in our\u0000tertiary care teaching hospital.\u0000Methods: Based on the inclusion and exclusion criteria n=40\u0000cases were identified and treated with laparoscopic\u0000cholecystectomy. A complete history which included the pasthistory, family history, socioeconomic status, nature of\u0000symptoms, diet history was obtained. All the patients\u0000underwent a complete clinical examination. The investigations\u0000carried out were complete blood picture, bleeding time,\u0000clotting time, ECG, LFT, KFT, FBS, blood groups, chest x-ray,\u0000and Ultrasound scan of the abdomen. All cases were operated\u0000as per the standard procedures.\u0000Results: The most common sign recorded in the cases was pain\u0000in right hypochondrium. Out of n=40 cases, 95% were present\u0000with pain 5% was without pain. Clinical jaundice was found in\u000010% of cases and tenderness was found on examination in 95%\u0000of cases. USG showed the presence of multiple stones was in\u000076% of cases, thickening of the gall bladder was in 80% cases\u0000and presence of mass was detected in 8% of cases. The follow-up period was 3 months in which no complications were\u0000reported.\u0000Conclusion: The study found that most of the cases of\u0000cholelithiasis now occurring across the spectrum of different\u0000ages. The diagnosis has now become easy with the presence\u0000of ultrasonography which has sensitivity and specificity. The\u0000motto of safe surgery, low morbidity, and early back to work is\u0000best done with laparoscopic cholecystectomy.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43333734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spandana Kanaparthi, S. Jana, Ravider Reddy Kasturi, N. Mudgalkar
Background: Heart failure in women associated with pregnancy and the peripartum period is now recognized as a distinctive form of cardiomyopathy. Its prevalence and mortality vary in different geographical locations. There is a paucity of data from our group of the population regarding peripartum cardiomyopathy hence we conducted the study to determine the incidence, aetiology of PPCM in our study group along with treatment and maternal outcomes. Methods: Patients with any parity and age, which are in their peripartum period i.e. one month before delivery or within five months of delivery. Patients presenting with moderate to severe breathlessness at rest or on exertion with palpitations, ankle oedema, or with signs and symptoms of heart failure. Documented systolic dysfunction with the echocardiographic finding of Ejection fraction of <45% and or Fractional shortening <30%, absence of another identifiable cause for the HF. Results: Overall incidence of PPCM in our institution is 9 per 1000 deliveries. Among n=67 PPCM cases, n=26 patients (38.80%) developed PPCM during pregnancy and n=41 patients (61.2%) during postpartum period. The majority of the patients n=49 cases (73.13%) had severe left ventricular systolic dysfunction (EF =30%) and n=10 (14.92%) had moderate left ventricular systolic dysfunction and n=8 had mild LV dysfunction. There was no significant statistical difference in the severity of LV dysfunction between primi and multiparous women. Conclusion: The main factors are advanced maternal age and multiparity. Twin pregnancies are also risk factors for the development of PPCM. Yet another important risk factor was Pre-eclampsia. There is no single explanation for the pathogenesis of PPCM that is relevant for all women. Recognition of symptoms of breathlessness, orthopnea, and pedal edema in the post-partum period with a history of preeclampsia should arouse a high degree of suspicion.
{"title":"A Study of Incidence and outcome of Peripartum Cardiomyopathy in a Tertiary Care Teaching Hospital","authors":"Spandana Kanaparthi, S. Jana, Ravider Reddy Kasturi, N. Mudgalkar","doi":"10.47799/pimr.0902.13","DOIUrl":"https://doi.org/10.47799/pimr.0902.13","url":null,"abstract":"Background: Heart failure in women associated with\u0000pregnancy and the peripartum period is now recognized as a\u0000distinctive form of cardiomyopathy. Its prevalence and\u0000mortality vary in different geographical locations. There is a\u0000paucity of data from our group of the population regarding\u0000peripartum cardiomyopathy hence we conducted the study\u0000to determine the incidence, aetiology of PPCM in our study\u0000group along with treatment and maternal outcomes.\u0000Methods: Patients with any parity and age, which are in their\u0000peripartum period i.e. one month before delivery or within\u0000five months of delivery. Patients presenting with moderate to\u0000severe breathlessness at rest or on exertion with palpitations,\u0000ankle oedema, or with signs and symptoms of heart failure.\u0000Documented systolic dysfunction with the echocardiographic\u0000finding of Ejection fraction of <45% and or Fractional\u0000shortening <30%, absence of another identifiable cause for\u0000the HF.\u0000Results: Overall incidence of PPCM in our institution is 9 per\u00001000 deliveries. Among n=67 PPCM cases, n=26 patients\u0000(38.80%) developed PPCM during pregnancy and n=41 patients\u0000(61.2%) during postpartum period. The majority of the patients\u0000n=49 cases (73.13%) had severe left ventricular systolic\u0000dysfunction (EF =30%) and n=10 (14.92%) had moderate left\u0000ventricular systolic dysfunction and n=8 had mild LV\u0000dysfunction. There was no significant statistical difference in\u0000the severity of LV dysfunction between primi and multiparous\u0000women.\u0000Conclusion: The main factors are advanced maternal age and\u0000multiparity. Twin pregnancies are also risk factors for the\u0000development of PPCM. Yet another important risk factor was\u0000Pre-eclampsia. There is no single explanation for the\u0000pathogenesis of PPCM that is relevant for all women.\u0000Recognition of symptoms of breathlessness, orthopnea, and\u0000pedal edema in the post-partum period with a history of preeclampsia should arouse a high degree of suspicion.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41543823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Anaemia is one of the major public health problems worldwide. Commonest nutritional deficiency affecting more than 1.2 billion individuals worldwide 1. Iron deficiency anaemia is associated with a reduction in physical well being and decreased exercise capacity. The prevalence of anaemia is 30% in stable heart failure and 50% in hospitalized heart failure patients, compared with less than 10% in the general population 2.In iron deficiency anaemia, to maintain adequate oxygen delivery, cardiac output can increase by the compensatory increase in blood volume, preload, heart rate, and stroke volume, and decrease in afterload.If severe iron deficiency anaemia left untreated, it could cause secondary organ damage. Chronic severe iron deficiency anaemia causes cardiac remodelling, cardiomegaly, arrhythmia, left ventricular hypertrophy, and heart failure. Aim: To study the left ventricular dysfunction in patients with severe iron deficiency admitted in a tertiary care hospital. Materials and Methods: A Hospital-based Prospective study was conducted in the Department of Medicine, Santhiram medical college & general hospital for a 2 year period. Universal Sampling Technique was used for the selection of study subjects. All the patients coming to the medicine department during the study period with age > 18years with informed written consent taken from the patient,Hemoglobin< 6gm/dl (according to WHO criteria) and Red cell indices suggestive of iron deficiency anaemia The final sample size was 100 subjects. Results: Out of 100 patients, 62% were females, and 38% were males in the study group. The mean age in the study population was 40.68±12.5 years, with the minimum age being 18 years and maximum age is 70 years. The prevalence of LV dysfunction in the study group was 61%.51% of the total population had systolic dysfunction and 10% had diastolic dysfunction.39% of the total population had normal LV function. In patients with systolic dysfunction, 72.5% were females, and 27.5% were males. In diastolic dysfunction, 50% were males, and 50% were females. Conclusion: As iron deficiency anaemia is more prevalent globally, its consequences on the cardiovascular system were studied. Iron deficiency anaemia is a major public health problem in developing countries, and it causes major cardiovascular morbidity and mortality. Severe iron deficiency anaemia causes structural changes in the left ventricle leading to eccentric or concentric hypertrophy, which predisposes the patients to develop left ventricular dysfunction. Hence, early diagnosis and management of iron deficiency anaemia can reverse remodelling and prevent left ventricular dysfunction. Thus, reducing major cardiovascular morbidity and mortality.
{"title":"A Study of Left Ventricular Dysfunction in Patients with Severe Iron Deficiency in a Tertiary Care Hospital, Nandyal","authors":"Nagarjuna Reddy Pogula","doi":"10.47799/pimr.0902.11","DOIUrl":"https://doi.org/10.47799/pimr.0902.11","url":null,"abstract":"Background: Anaemia is one of the major public health\u0000problems worldwide. Commonest nutritional deficiency\u0000affecting more than 1.2 billion individuals worldwide 1. Iron\u0000deficiency anaemia is associated with a reduction in physical\u0000well being and decreased exercise capacity. The prevalence of\u0000anaemia is 30% in stable heart failure and 50% in hospitalized\u0000heart failure patients, compared with less than 10% in the\u0000general population 2.In iron deficiency anaemia, to maintain\u0000adequate oxygen delivery, cardiac output can increase by the\u0000compensatory increase in blood volume, preload, heart rate,\u0000and stroke volume, and decrease in afterload.If severe iron\u0000deficiency anaemia left untreated, it could cause secondary\u0000organ damage. Chronic severe iron deficiency anaemia causes\u0000cardiac remodelling, cardiomegaly, arrhythmia, left ventricular\u0000hypertrophy, and heart failure.\u0000Aim: To study the left ventricular dysfunction in patients with\u0000severe iron deficiency admitted in a tertiary care hospital.\u0000Materials and Methods: A Hospital-based Prospective study\u0000was conducted in the Department of Medicine, Santhiram\u0000medical college & general hospital for a 2 year period. Universal\u0000Sampling Technique was used for the selection of study\u0000subjects. All the patients coming to the medicine department\u0000during the study period with age > 18years with informed\u0000written consent taken from the patient,Hemoglobin< 6gm/dl\u0000(according to WHO criteria) and Red cell indices suggestive of\u0000iron deficiency anaemia The final sample size was 100 subjects.\u0000Results: Out of 100 patients, 62% were females, and 38% were\u0000males in the study group. The mean age in the study population\u0000was 40.68±12.5 years, with the minimum age being 18 years\u0000and maximum age is 70 years. The prevalence of LV dysfunction\u0000in the study group was 61%.51% of the total population had\u0000systolic dysfunction and 10% had diastolic dysfunction.39% of\u0000the total population had normal LV function. In patients with\u0000systolic dysfunction, 72.5% were females, and 27.5% were\u0000males. In diastolic dysfunction, 50% were males, and 50% were\u0000females.\u0000Conclusion: As iron deficiency anaemia is more prevalent\u0000globally, its consequences on the cardiovascular system were\u0000studied. Iron deficiency anaemia is a major public health\u0000problem in developing countries, and it causes major\u0000cardiovascular morbidity and mortality. Severe iron deficiency\u0000anaemia causes structural changes in the left ventricle leading\u0000to eccentric or concentric hypertrophy, which predisposes the\u0000patients to develop left ventricular dysfunction. Hence, early\u0000diagnosis and management of iron deficiency anaemia can\u0000reverse remodelling and prevent left ventricular dysfunction.\u0000Thus, reducing major cardiovascular morbidity and mortality.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48610204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Labour is a unique experience in a normal woman's life. If it is prolonged and tedious it may produce a picture of mental anguish and physical morbidity. For the newborn child, prolonged labor will pose danger to its survival and subsequent neurological development. We in the current study tried to evaluate the use of partograms for spontaneous and induced labor in primi and multis para women. Methods: A total of n=150 cases were studied, and this includes both primis and multigravidae attending Prathima Hospital. They were divided into 3 groups (groups A, B & C) patients in normal true labor and those in whom induction was used. The induced group was again divided into those induced with PGE2 gel or oxytocin. The modified WHO partogram starts with 4cms cervical dilatation. partograms were plotted to assess the progress of labor in each group and analyzed. Results: Group A for 52% primis and 64% multis the partogram fell before the alert line i.e. thedelivered before reaching the alert line, Group – B 56% primis and 48% multis in the partogrammoved between the alert and action lines. In GroupA 8% primis and 1% multis have reached orcrossed the action line. 12% primis and 1% multis in group-B have reached or crossed the actionline. 28% primis and 16% multis in group-C have reached or crossed the action line,Interventions like forceps delivery or cesarean section was done for those who have reached orcrossed the action line Conclusion: Partogram is a useful Non-invasive tool for monitoring the progress of labor in both spontaneous and induced labor for primis and multis. The Maternal and Fetal outcome is extremely favorable when partographic monitoring is done in parturients. The partogram helps us to take up decisive interventions in the form of accelerating labor, instrumental vaginal delivery (outlet Forceps/ventouse), and cesarean section
{"title":"Comparison of Partograms for Spontaneous and Induced\u0000Labour","authors":"T. Parijatha, G. Vijayabharathi","doi":"10.47799/pimr.0902.10","DOIUrl":"https://doi.org/10.47799/pimr.0902.10","url":null,"abstract":"Background: Labour is a unique experience in a normal\u0000woman's life. If it is prolonged and tedious it may produce a\u0000picture of mental anguish and physical morbidity. For the newborn child, prolonged labor will pose danger to its survival and\u0000subsequent neurological development. We in the current study\u0000tried to evaluate the use of partograms for spontaneous and\u0000induced labor in primi and multis para women.\u0000Methods: A total of n=150 cases were studied, and this includes\u0000both primis and multigravidae attending Prathima Hospital.\u0000They were divided into 3 groups (groups A, B & C) patients in\u0000normal true labor and those in whom induction was used. The\u0000induced group was again divided into those induced with PGE2\u0000gel or oxytocin. The modified WHO partogram starts with 4cms\u0000cervical dilatation. partograms were plotted to assess the\u0000progress of labor in each group and analyzed.\u0000Results: Group A for 52% primis and 64% multis the partogram\u0000fell before the alert line i.e. thedelivered before reaching the\u0000alert line, Group – B 56% primis and 48% multis in the\u0000partogrammoved between the alert and action lines. In GroupA 8% primis and 1% multis have reached orcrossed the action\u0000line. 12% primis and 1% multis in group-B have reached or\u0000crossed the actionline. 28% primis and 16% multis in group-C\u0000have reached or crossed the action line,Interventions like\u0000forceps delivery or cesarean section was done for those who\u0000have reached orcrossed the action line\u0000Conclusion: Partogram is a useful Non-invasive tool for\u0000monitoring the progress of labor in both spontaneous and\u0000induced labor for primis and multis. The Maternal and Fetal\u0000outcome is extremely favorable when partographic monitoring\u0000is done in parturients. The partogram helps us to take up\u0000decisive interventions in the form of accelerating labor,\u0000instrumental vaginal delivery (outlet Forceps/ventouse), and\u0000cesarean section","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42520497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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