Suryakanth Kalluraya, A. Hosangadi, S. Í., Nagendra Prasad M
Abstract It was believed that “all clavicle fractures heal well” is no longer valid. Recent trend is towards operative management, consists of Pre-contoured plate or Titanium Elastic Nail System(TENS) application. Plate fixation remains the mainstay of treatment but Titanium Elastic Nail System application has gained attention in recent years. This study highlights the comparison between two most common modalities available for treatment of mid-shaft clavicle fractures. Objectives:Compare the functional outcome using Neer’s scoring system, radiological outcome and secondary outcomes between two treatment groups. Methods:Patients satisfying inclusion criteria were included in our study and randomized into Group A-operated with plate fixation and Group B-operated with TENS. Routine postoperative protocol and physiotherapy followed. Regular follow up carried out and assessed as per protocol. Results: We had 15 patients in each group by end of our study. There was no significant difference between the two groups in terms of demographics, time to surgery, fracture types. Duration of hospital stay, mean fracture union time were significantly shorter and cosmetically more satisfied in TENS group. Operative time, length of incision, peri-operative blood loss was significantly higher in plate group and length of clavicle better restored. Functional outcome was excellent with no significant difference between two groups. Conclusion:Both methods return the patients to their pre-injury functional levels without significant complications with excellent functional outcome. Titanium Elastic Nail System application has a shorter operative time, lesser duration of hospital stay, lower infection rate and better cosmetic outcome suggesting this is the preferred method with no comminution whereas plate fixation is superior in comminuted fractures.
{"title":"Mid Shaft Clavicle Fractures- Plate vs Titanium Elastic Nail System","authors":"Suryakanth Kalluraya, A. Hosangadi, S. Í., Nagendra Prasad M","doi":"10.47799/pimr.1003.04","DOIUrl":"https://doi.org/10.47799/pimr.1003.04","url":null,"abstract":"Abstract\u0000 It was believed that “all clavicle fractures heal well” is no longer valid. Recent trend is towards operative management, consists of Pre-contoured plate or Titanium Elastic Nail System(TENS) application. Plate fixation remains the mainstay of treatment but Titanium Elastic Nail System application has gained attention in recent years. This study highlights the comparison between two most common modalities available for treatment of mid-shaft clavicle fractures.\u0000 \u0000 Objectives:Compare the functional outcome using Neer’s scoring system, radiological outcome and secondary outcomes between two treatment groups.\u0000 \u0000 Methods:Patients satisfying inclusion criteria were included in our study and randomized into Group A-operated with plate fixation and Group B-operated with TENS. Routine postoperative protocol and physiotherapy followed. Regular follow up carried out and assessed as per protocol.\u0000 \u0000 Results: We had 15 patients in each group by end of our study. There was no significant difference between the two groups in terms of demographics, time to surgery, fracture types. Duration of hospital stay, mean fracture union time were significantly shorter and cosmetically more satisfied in TENS group. Operative time, length of incision, peri-operative blood loss was significantly higher in plate group and length of clavicle better restored. Functional outcome was excellent with no significant difference between two groups.\u0000 \u0000 Conclusion:Both methods return the patients to their pre-injury functional levels without significant complications with excellent functional outcome. Titanium Elastic Nail System application has a shorter operative time, lesser duration of hospital stay, lower infection rate and better cosmetic outcome suggesting this is the preferred method with no comminution whereas plate fixation is superior in comminuted fractures.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42543022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background Quality control in histopathology is relatively newer concept and less understood because of its subjectivity. Aim:The present study was conducted to assess and determine applicability of the different elements of quality assurance in the histopathology laboratory of a tertiary care hospital in eastern region of India. Material and methods: An observational, retrospective and analytic study for one year and three months was conducted. 2000 samples were selected by simple random sampling including the biopsy specimens and cell blocks received in the histopathology laboratory. Results:Of the 2000 samples, 1880 (94%) were accepted and 120 rejected (6%) due to mainly pre analytical factors. Of the rejected samples, 35 samples (29.2%) were without proper fixative, 48 samples (40%) had incomplete requisition forms, 37 samples (30.8%) had incomplete/ absent clinical history. Lack of adherence to standard tissue fixation protocols were observed in 55 cases (2.75%). Inadequate preventive maintenance and delay in renewal of maintenance contracts were the most common cause of failure of maintenance of equipment. Improper staining was found in 35 cases (1.75%). Grossing of specimens were inadequate in 104 cases (5.2%). Concurrence in diagnosis was found in majority cases (1892 cases, 94.6%). Random case review was done with adequate precision (97.5%) and accuracy (96.6 %). Maintenance of turnaround time was found in most cases (1800 cases, 90%). Conclusion: Standard operating procedures, training of staffs, equipment maintenance, alertness to maintain turnaround time and awareness, proper report documentation and storage are the key factors to successfully uphold quality assurance.
{"title":"Assessment and Applicability of Various Elements of Quality Assurance in Histopathology Laboratory: A Study from A Tertiary Care Hospital in Eastern Region of India","authors":"D. Mallick, S. Chakrabarti, Prosun Gayen","doi":"10.47799/pimr.1003.05","DOIUrl":"https://doi.org/10.47799/pimr.1003.05","url":null,"abstract":"Abstract\u0000 \u0000 Background Quality control in histopathology is relatively newer concept and less understood because of its subjectivity.\u0000 \u0000 Aim:The present study was conducted to assess and determine applicability of the different elements of quality assurance in the histopathology laboratory of a tertiary care hospital in eastern region of India.\u0000 \u0000 Material and methods: An observational, retrospective and analytic study for one year and three months was conducted. 2000 samples were selected by simple random sampling including the biopsy specimens and cell blocks received in the histopathology laboratory.\u0000 \u0000 Results:Of the 2000 samples, 1880 (94%) were accepted and 120 rejected (6%) due to mainly pre analytical factors. Of the rejected samples, 35 samples (29.2%) were without proper fixative, 48 samples (40%) had incomplete requisition forms, 37 samples (30.8%) had incomplete/ absent clinical history. Lack of adherence to standard tissue fixation protocols were observed in 55 cases (2.75%). Inadequate preventive maintenance and delay in renewal of maintenance contracts were the most common cause of failure of maintenance of equipment. Improper staining was found in 35 cases (1.75%). Grossing of specimens were inadequate in 104 cases (5.2%). Concurrence in diagnosis was found in majority cases (1892 cases, 94.6%). Random case review was done with adequate precision (97.5%) and accuracy (96.6 %). Maintenance of turnaround time was found in most cases (1800 cases, 90%).\u0000 \u0000 Conclusion: Standard operating procedures, training of staffs, equipment maintenance, alertness to maintain turnaround time and awareness, proper report documentation and storage are the key factors to successfully uphold quality assurance.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47127550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Self Directed Learning (SDL) was defined by Knowles as ‘the process in which individuals take the initiative themselves with or without taking help of others for diagnosing their learning needs. The SDLR Scale is a validated tool used to assess that to which extent an individual possesses self-directed learning personality characteristics and attitude. This cross sectional survey was planned among phase I medical students . Sample size was 100 utilizing convenient sample of phase I medical students. Structured Questionnaire ‘Self-directed learning readiness scale’ SDLRD questionnaire was used to collect the data; the scale was first designed and tested by Fisher et al. Data were analyzed using Microsoft excel, Median, mean and Standard deviation for each individual item and for total score as well as for the three sub-scales were tabulated . Differences between groups were tested using the chi square or t test. The mean and median SDLR score of whole questionnaire for was 146.18±19.81. Majority of the first year medical students had shown readiness for self-directed learning. SDL scores were lower among our MBBS students than reported in studies done elsewhere. This study points out the need to address our students’ SDL skills, and need for ways to build SDL skills in our students.
{"title":"Self Directed Learning Readiness among phase I undergraduate Medical students","authors":"Afshan Kausar, Akshay Berad","doi":"10.47799/pimr.1003.07","DOIUrl":"https://doi.org/10.47799/pimr.1003.07","url":null,"abstract":"Abstract\u0000 Self Directed Learning (SDL) was defined by Knowles as ‘the process in which individuals take the initiative themselves with or without taking help of others for diagnosing their learning needs. The SDLR Scale is a validated tool used to assess that to which extent an individual possesses self-directed learning personality characteristics and attitude. This cross sectional survey was planned among phase I medical students . Sample size was 100 utilizing convenient sample of phase I medical students. Structured Questionnaire ‘Self-directed learning readiness scale’ SDLRD questionnaire was used to collect the data; the scale was first designed and tested by Fisher et al. Data were analyzed using Microsoft excel, Median, mean and Standard deviation for each individual item and for total score as well as for the three sub-scales were tabulated . Differences between groups were tested using the chi square or t test. The mean and median SDLR score of whole questionnaire for was 146.18±19.81. Majority of the first year medical students had shown readiness for self-directed learning. SDL scores were lower among our MBBS students than reported in studies done elsewhere. This study points out the need to address our students’ SDL skills, and need for ways to build SDL skills in our students.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44412721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amjad Shaikh, Ishrat Fatema, Vijay L Deshmukh, Mohd Mudassir Shaikh, J. Syed
Abstract Introduction: The extravasation of saliva from the sublingual gland on the floor of the mouth results in a ranula. The most typical presentation is swelling under the tongue. The mylohyoid muscle may allow it to herniate, Causing a plunging ranula. Ranula can be treated in many ways, including ranula excision alone, excision of the sublingual gland with or without ranula, aspiration of cystic fluid, sclerotherapy, marsupialization, incision and drainage. Material and methods: This case study includes six patients with ranula who underwent surgical treatment by marsupialization. The indications, age and sex distribution, Marsupialization methods, pathology reports, recurrence rates, and complications were seen. Results: Out of 6 patients in our case series, no one patient has shown to be any recurrence or complications of marsupialization. Conclusions: Management of Ranula by Marsupialization is a good option, but if it recurs after marsupialization, Excision of the lesion and the affected gland is the best course of action.
{"title":"S\u0000 urgical \u0000 Management of Ranula-\u0000 \u0000 F\u0000 loor of \u0000 M\u0000 outh by \u0000 M\u0000 arsupialization: A \u0000 C\u0000 ase \u0000 Series.","authors":"Amjad Shaikh, Ishrat Fatema, Vijay L Deshmukh, Mohd Mudassir Shaikh, J. Syed","doi":"10.47799/pimr.1003.11","DOIUrl":"https://doi.org/10.47799/pimr.1003.11","url":null,"abstract":"Abstract\u0000 Introduction: The extravasation of saliva from the sublingual gland on the floor of the mouth results in a ranula. The most typical presentation is swelling under the tongue. The mylohyoid muscle may allow it to herniate, Causing a plunging ranula. Ranula can be treated in many ways, including ranula excision alone, excision of the sublingual gland with or without ranula, aspiration of cystic fluid, sclerotherapy, marsupialization, incision and drainage.\u0000 Material and methods: This case study includes six patients with ranula who underwent surgical treatment by marsupialization. The indications, age and sex distribution, Marsupialization methods, pathology reports, recurrence rates, and complications were seen.\u0000 Results: Out of 6 patients in our case series, no one patient has shown to be any recurrence or complications of marsupialization.\u0000 Conclusions: Management of Ranula by Marsupialization is a good option, but if it recurs after marsupialization, Excision of the lesion and the affected gland is the best course of action.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42195509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background: Acute respiratory illness with fever and respiratory symptoms such as cough and shortness of breath comprise the main clinical presentations of Corona virus disease (COVID-19).Clinical manifestations in COVID-19 shows significant regional variations. Objective of the study: To study the demographic and clinical profiles of laboratory confirmed COVID-19 patients in South India Methods: In this cross sectional study,patients diagnosed with COVID-19 by reverse transcriptase-polymerase chain reaction (RT-PCR) test were taken up for the study.History of fever,throatpain,cough,breathlessness,malaise were taken.Blood pressure,respiratory rate,oxygen saturation were recorded.Data on co-morbid illnessness like diabetes,hypertension,renal disease were also noted .All these were correlated to assess the clinical course of COVID-19 Results: Of the total 518 patients,257(49.6%) patients were in the age group of 46 to 65 years and 309 (59.7 %) patients were males. History of fever was present in 349(67.38%) patients and cough was present in 291 (56.17%) patients. Throat pain and running nose was present in 291 (56.2%)and 110 (21.23%) patients respectively. Heart rate was between 60 and 100 beats per minute in 472 (80.3%) of patients and 102 (19.7%) patients had respiratory distress with respiratory rate ≥24. Oxygen saturation was between 90-93% in 57 (9.85%) patients and 87(16.8%) patients were on oxygen support with 21(4.1%) patients on non-invasive ventilation. A total of 291(56.2%) patients were treated with steroids. Diabetes mellitus was present in 214(41.3%), hypertension in 150 (29%) patients. Case fatality rate was 2.1% Conclusion: Severe disease and lower oxygen saturation was associated with older age and co-morbid diseases particularly diabetes
{"title":"Clinical and demographic profile of COVID-19 patients- A cross-sectional study from a tertiary care medical college hospital from South India","authors":"N. Ramya, J. E. J. Shanu, S. Prabhu Shankar","doi":"10.47799/pimr.1003.16","DOIUrl":"https://doi.org/10.47799/pimr.1003.16","url":null,"abstract":"Abstract\u0000 \u0000 Background: Acute respiratory illness with fever and respiratory symptoms such as cough and shortness of breath comprise the main clinical presentations of Corona virus disease (COVID-19).Clinical manifestations in COVID-19 shows significant regional variations.\u0000 \u0000 Objective of the study: To study the demographic and clinical profiles of laboratory confirmed COVID-19 patients in South India\u0000 \u0000 Methods:\u0000 In this cross sectional study,patients diagnosed with COVID-19 by reverse transcriptase-polymerase chain reaction (RT-PCR) test were taken up for the study.History of fever,throatpain,cough,breathlessness,malaise were taken.Blood pressure,respiratory rate,oxygen saturation were recorded.Data on co-morbid illnessness like diabetes,hypertension,renal disease were also noted .All these were correlated to assess the clinical course of COVID-19\u0000 \u0000 Results:\u0000 Of the total 518 patients,257(49.6%) patients were in the age group of 46 to 65 years and 309 (59.7 %) patients were males. History of fever was present in 349(67.38%) patients and cough was present in 291 (56.17%) patients. Throat pain and running nose was present in 291 (56.2%)and 110 (21.23%) patients respectively. Heart rate was between 60 and 100 beats per minute in 472 (80.3%) of patients and 102 (19.7%) patients had respiratory distress with respiratory rate ≥24. Oxygen saturation was between 90-93% in 57 (9.85%) patients and 87(16.8%) patients were on oxygen support with 21(4.1%) patients on non-invasive ventilation. A total of 291(56.2%) patients were treated with steroids. Diabetes mellitus was present in 214(41.3%), hypertension in 150 (29%) patients. Case fatality rate was 2.1%\u0000 \u0000 Conclusion: Severe disease and lower oxygen saturation was associated with older age and co-morbid diseases particularly diabetes","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43162941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract INTRODUCTION: Titanium elastic nails are used to treat femur shaft fractures in paediatric patients. This method is minimally invasive and does not cause epiphyseal injury or impairment of femoral head blood supply. OBJECTIVES: The objective is to evaluate the results of operative treatment of femur shaft fractures in the age group between 6 and 16 years with titanium elastic nailing system (TENS), using Flynn’s criteria. METHODS: This prospective clinical study was conducted during the period from November 2018 to November 2020. Thirty cases were treated with mean follow up of 12 months. RESULTS: The final outcome was excellent in 21 cases, satisfactory in 6 cases and there were 3 poor outcome cases. Eight patients had limb length discrepancy varying from 0.5-2cm. Five patients had skin irritation, 3 patients had angular mal-union and 1 patient had persistent pain with skin breakdown. None of the patient had infection, rotational mal-union, delayed or non union. CONCLUSION: Titanium elastic nail fixation is a simple, easy and effective method for management of paediatric femur fracture between 6 and 16 years age. With this method of treatment, careful consideration to patient’s age and body weight should be given to prevent the poor result.
{"title":"Femur shaft fracture treatment in school-aged children using titanium elastic nails","authors":"M. R, Ateet P. Babli, Venkatesh Mulimani","doi":"10.47799/pimr.1003.09","DOIUrl":"https://doi.org/10.47799/pimr.1003.09","url":null,"abstract":"Abstract\u0000 INTRODUCTION: Titanium elastic nails are used to treat femur shaft fractures in paediatric patients. This method is minimally invasive and does not cause epiphyseal injury or impairment of femoral head blood supply.\u0000 OBJECTIVES: The objective is to evaluate the results of operative treatment of femur shaft fractures in the age group between 6 and 16 years with titanium elastic nailing system (TENS), using Flynn’s criteria.\u0000 METHODS: This prospective clinical study was conducted during the period from November 2018 to November 2020. Thirty cases were treated with mean follow up of 12 months. \u0000 RESULTS: The final outcome was excellent in 21 cases, satisfactory in 6 cases and there were 3 poor outcome cases. Eight patients had limb length discrepancy varying from 0.5-2cm. Five patients had skin irritation, 3 patients had angular mal-union and 1 patient had persistent pain with skin breakdown. None of the patient had infection, rotational mal-union, delayed or non union. \u0000 CONCLUSION: Titanium elastic nail fixation is a simple, easy and effective method for management of paediatric femur fracture between 6 and 16 years age. With this method of treatment, careful consideration to patient’s age and body weight should be given to prevent the poor result.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42949685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: Vitamin D deficiency and Obesity are the two prevailing health issues of the globe, with India being no exception. The sub optimal Vitamin D levels is associated with an elevated risk of a number of chronic disorders including malignancy, inflammation and autoimmune diseases. Obesity breeds metabolic disharmony. Recent data reports Vitamin D deficiency being more prevalent among the obese. Objective: This study is undertaken to see the association of Vitamin D levels with Body Mass Index (BMI), Lipid parameters and Insulin resistance in a sample population representing the urban Indian youth. Materials and Method: Fifty five apparently healthy young adults of 18 to 22 years age were recruited in this study and their serum 25-hydroxycholecalciferol(25OHD), serum insulin, Total Cholesterol, High Density lipoprotein-cholesterol (HDL-c), Low Density lipoprotein- cholesterol (LDL-c) and Triglyceride (TGL) levels were estimated. Insulin resistance(IR) was derived using the Homeostasis Model Assessment equation. Based on BMI, the participants were divided into Obese group with BMI ≥ 25 (n=21) and non-obese group with BMI < 25 (n=34). Result: 25OHD levels were almost same in both Groups (Obese11.1 ± 4.6 ng/ml and non-obese 11.0 ± 5.2 ng/ml). Serum total cholesterol, VLDL and insulin levels were significantly increased in the Obese group(p= 0.005, p= 0.015 and p=0.054 respectively) when compared to the non-obese group. We found statistically significant association between 25-hydroxycholecalciferol (25OHD) and TGL/HDL ratio in the Obese group. Conclusion: In this pilot study we have unravelled the subtle onset of metabolic derangement in Obese individuals with Vitamin D deficiency.
{"title":"25-Hydroxycholecalciferol levels and its equation with lipid parameters and Insulin sensitivity in obese and non-obese young adults: A pilot study","authors":"N. Chandrika, Usha Smr, Victoria Kshetrimayum","doi":"10.47799/pimr.1003.08","DOIUrl":"https://doi.org/10.47799/pimr.1003.08","url":null,"abstract":"Abstract\u0000 \u0000 Introduction: Vitamin D deficiency and Obesity are the two prevailing health issues of the globe, with India being no exception. The sub optimal Vitamin D levels is associated with an elevated risk of a number of chronic disorders including malignancy, inflammation and autoimmune diseases. Obesity breeds metabolic disharmony. Recent data reports Vitamin D deficiency being more prevalent among the obese. \u0000 \u0000 Objective: This study is undertaken to see the association of Vitamin D levels with Body Mass Index (BMI), Lipid parameters and Insulin resistance in a sample population representing the urban Indian youth.\u0000 \u0000 Materials and Method: Fifty five apparently healthy young adults of 18 to 22 years age were recruited in this study and their serum 25-hydroxycholecalciferol(25OHD), serum insulin, Total Cholesterol, High Density lipoprotein-cholesterol (HDL-c), Low Density lipoprotein- cholesterol (LDL-c) and Triglyceride (TGL) levels were estimated. Insulin resistance(IR) was derived using the Homeostasis Model Assessment equation. Based on BMI, the participants were divided into Obese group with BMI ≥ 25 (n=21) and non-obese group with BMI < 25 (n=34).\u0000 \u0000 Result: 25OHD levels were almost same in both Groups (Obese11.1 ± 4.6 ng/ml and non-obese 11.0 ± 5.2 ng/ml). Serum total cholesterol, VLDL and insulin levels were significantly increased in the Obese group(p= 0.005, p= 0.015 and p=0.054 respectively) when compared to the non-obese group. We found statistically significant association between 25-hydroxycholecalciferol (25OHD) and TGL/HDL ratio in the Obese group.\u0000 \u0000 Conclusion: In this pilot study we have unravelled the subtle onset of metabolic derangement in Obese individuals with Vitamin D deficiency.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45715429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: Hypertension is a major risk factor for cardiovascular diseases. Raised homocysteine level is also an important independent risk factor for CVD. This study sought to determine whether there is any relationship between plasma homocysteine and blood pressure levels. Method: A case control study was conducted among 200 hypertensive cases and 200 normal healthy control groups. Cases were from the Department of medicine and hypertensive clinics at GMC, Baramati and similar controls were selected from patients’ neighborhood. Detailed clinical assessment as well as plasma homocysteine level were assessed and compared in both. Results: Hypertensive cases had higher mean homocysteine level (21.3 ± 4.6 μmol/L) from controls (13.0 ± 6.0 μmol/L), p<0.001. Homocysteine is positively correlated with both systolic and diastolic blood pressure among both hypertensive patients and healthy controls. In both hypertensive subjects and healthy control, homocysteine level has weak positive correlation with DBP and moderate to strong positive correlation with SBP. The hypertensive cases had very high chance (OR=52.4) of developing hyperhomocysteinemia (>15 μmol/L), p<0.001. Conclusion: This study showed higher mean plasma homocysteine levels in hypertensive subjects than controls. Serum homocysteine concentrations were positively associated with both systolic and diastolic blood pressure levels in a general adult population.
{"title":"Association of high blood pressure with raised homocysteine level among urban population- A case control study","authors":"Mehraj A Junedi, Abdulazim A Junaidi, R. Yadagir","doi":"10.47799/pimr.1003.13","DOIUrl":"https://doi.org/10.47799/pimr.1003.13","url":null,"abstract":"Abstract\u0000 \u0000 Introduction: Hypertension is a major risk factor for cardiovascular diseases. Raised homocysteine level is also an important independent risk factor for CVD. This study sought to determine whether there is any relationship between plasma homocysteine and blood pressure levels. \u0000 \u0000 Method: A case control study was conducted among 200 hypertensive cases and 200 normal healthy control groups. Cases were from the Department of medicine and hypertensive clinics at GMC, Baramati and similar controls were selected from patients’ neighborhood. Detailed clinical assessment as well as plasma homocysteine level were assessed and compared in both. \u0000 \u0000 Results: Hypertensive cases had higher mean homocysteine level (21.3 ± 4.6 μmol/L) from controls (13.0 ± 6.0 μmol/L), p<0.001. Homocysteine is positively correlated with both systolic and diastolic blood pressure among both hypertensive patients and healthy controls. In both hypertensive subjects and healthy control, homocysteine level has weak positive correlation with DBP and moderate to strong positive correlation with SBP. The hypertensive cases had very high chance (OR=52.4) of developing hyperhomocysteinemia (>15 μmol/L), p<0.001. \u0000 \u0000 Conclusion: This study showed higher mean plasma homocysteine levels in hypertensive subjects than controls. Serum homocysteine concentrations were positively associated with both systolic and diastolic blood pressure levels in a general adult population.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48202606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: Onychomycosis (OM) is a common nail disorder caused by dermatophytes, non-dermatophyte moulds and yeasts. The increased prevalence of OM along with the wide range of associated fungi necessitates the accurate laboratory isolation and identification of the causative fungus for optimal management strategies. The aim of the study was to evaluate clinical, epidemiological and mycological characteristics of OM at a tertiary care hospital in Karimnagar. Materials and Methods: The study was conducted at Department of Microbiology for a period of one year. 109 patients clinically diagnosed as OM were subjected to detailed history, clinical examination and investigations. Nail clippings and subungual debris of OM patients were subjected to KOH preparation and culture. Isolates were identified by colony characters, pigment production, microscopic morphology. Results: The maximum number of OM cases belonged to the age group 21-30 years with a male preponderance. Higher incidence was noted in males (71.5%) than females (28.4%). Direct microscopy of the nail clippings in 40% KOH solution was positive in 56.8% and culture was positive in 75.2% cases. The common etiological agent was dermatophytes (45.12% cases) followed by yeasts (34.14% and non dermatophyte molds (20.7% cases). T.rubrum was the commonest among dermatophytes and Candida albicans among the yeasts. Conclusions: Although onychomycosis is not life threatening, it can cause a significant negative impact on the quality of life of infected patients. Early diagnosis and treatment is important to prevent distortion of the nails which can prevent loss of working efficiency of the commonly affected population.
{"title":"Study of Clinico-mycological profile of onychomycosis at a tertiary care hospital","authors":"K. Sri Sandhya, B. Sita Maha Laxmi","doi":"10.47799/pimr.1003.02","DOIUrl":"https://doi.org/10.47799/pimr.1003.02","url":null,"abstract":"Abstract\u0000 \u0000 Introduction: Onychomycosis (OM) is a common nail disorder caused by dermatophytes, non-dermatophyte moulds and yeasts. The increased prevalence of OM along with the wide range of associated fungi necessitates the accurate laboratory isolation and identification of the causative fungus for optimal management strategies. The aim of the study was to evaluate clinical, epidemiological and mycological characteristics of OM at a tertiary care hospital in Karimnagar. \u0000 \u0000 Materials and Methods: The study was conducted at Department of Microbiology for a period of one year. 109 patients clinically diagnosed as OM were subjected to detailed history, clinical examination and investigations. Nail clippings and subungual debris of OM patients were subjected to KOH preparation and culture. Isolates were identified by colony characters, pigment production, microscopic morphology. \u0000 \u0000 Results: The maximum number of OM cases belonged to the age group 21-30 years with a male preponderance. Higher incidence was noted in males (71.5%) than females (28.4%). Direct microscopy of the nail clippings in 40% KOH solution was positive in 56.8% and culture was positive in 75.2% cases. The common etiological agent was dermatophytes (45.12% cases) followed by yeasts (34.14% and non dermatophyte molds (20.7% cases). T.rubrum was the commonest among dermatophytes and Candida albicans among the yeasts. \u0000 \u0000 Conclusions: Although onychomycosis is not life threatening, it can cause a significant negative impact on the quality of life of infected patients. Early diagnosis and treatment is important to prevent distortion of the nails which can prevent loss of working efficiency of the commonly affected population.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42672400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sayeedunnisa Sarah, Sarosh Ahmed Mohammed, Summaiyya Ahmed
Abstract Today as a lot of COVID 19 vaccines are available and are currently used, we conducted a study to assess the knowledge, attitudes and perceptions of medical students in our college. An online survey was conducted through GOOGLE forms. In this study total participants are 155 medical students of which 28.4% (n=44) males and 71.6% (n=111) are females. Effectiveness of vaccine as perceived by participants in our study is 65.2%. The safety of the vaccine as considered by participants in this study is 55.5% In this study it was also noticed that when gender is compared with effectiveness and safety of vaccine both males and females felt equally it is effective as well as safe to take vaccine. There is a need to increase trust among our medical students. The elements that define and build trust must be understood and interventions like health awareness programs as role plays, talks on social media involving known personalities can be undertaken and crafted accordingly to improve the knowledge regarding COVID 19. Most of the seniors shared their readiness to take the vaccine than junior students. It was also found that seniors felt that they do not get enough information about vaccines when compared to juniors. The main source of information regarding COVID 19 vaccine for majority of the participants i.e., 71% (n=110) was through internet and social media and 16.8% (n=26) get from health care workers and the least number of participants got information from family and friends. Hence social media and internet can be used in a more appropriate way to remove vaccine hesitancy.
{"title":"COVID-19 vaccine \u0000 – Knowledge, Attitude and practices among medical students in Hyderabad","authors":"Sayeedunnisa Sarah, Sarosh Ahmed Mohammed, Summaiyya Ahmed","doi":"10.47799/pimr.1003.12","DOIUrl":"https://doi.org/10.47799/pimr.1003.12","url":null,"abstract":"Abstract\u0000 Today as a lot of COVID 19 vaccines are available and are currently used, we conducted a study to assess the knowledge, attitudes and perceptions of medical students in our college. An online survey was conducted through GOOGLE forms. In this study total participants are 155 medical students of which 28.4% (n=44) males and 71.6% (n=111) are females. Effectiveness of vaccine as perceived by participants in our study is 65.2%. The safety of the vaccine as considered by participants in this study is 55.5% In this study it was also noticed that when gender is compared with effectiveness and safety of vaccine both males and females felt equally it is effective as well as safe to take vaccine.\u0000 There is a need to increase trust among our medical students. The elements that define and build trust must be understood and interventions like health awareness programs as role plays, talks on social media involving known personalities can be undertaken and crafted accordingly to improve the knowledge regarding COVID 19. \u0000 Most of the seniors shared their readiness to take the vaccine than junior students. It was also found that seniors felt that they do not get enough information about vaccines when compared to juniors. The main source of information regarding COVID 19 vaccine for majority of the participants i.e., 71% (n=110) was through internet and social media and 16.8% (n=26) get from health care workers and the least number of participants got information from family and friends. Hence social media and internet can be used in a more appropriate way to remove vaccine hesitancy.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42427971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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