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Correlation between the intensity of pulse longevity accumulation and the rate of oxygen demand formation and blood lactate accumulation in performing limiting cyclic exercises of different duration 不同持续时间极限循环运动中脉搏寿命积累强度与需氧量形成率和血乳酸积累率的相关性
Pub Date : 2023-01-16 DOI: 10.47529/2223-2524.2022.3.2
A. Kozlov, A. N. Bleer, S. Levushkin, V. Sonkin
The purpose of the study was to search for the relationship of Pulse Debt Accumulation Intensity (PDАI) with the rate of formation of oxygen demand and the accumulation of lactate in the blood during the performance of limiting cyclic exercises of various durations.Methods: 14 athletes‑cyclists (1st category, 20 ± 3 years, MОC — 52.9 ± 5.10 ml / min / kg), performed a series of bicycle ergometric exercises of maximum power on different days at a fixed duration of 10, 30, 60, 120, 360 and 1800 s. Based on the pulse sums of the five‑minute recovery (minus the pre‑start HR level) and the exercise time, the intensity of accumulation of pulse debt was calculated for all exercises in each subject. The rate of accumulation of lactate concentration in the blood (SNCL) and the rate of formation of oxygen demand (OCR) were also calculated.Results: SOCS, SNCL and PDАI have a close non‑linear relationship with exercise time (respectively: r2 = 0.84, r2 = 0.91, r2 = 0.96, at p < 0.05), as well as with relative exercise power (respectively: r2 = 0.80, r2 = 0.86, r2 = 0.90, at p < 0.05). INPD has a close relationship with SRCS and SNCL (respectively: r2 = 0.80, r2 = 0.94, p < 0.05).Conclusions: The results of the study make it possible to use the INPD heart rate indicator for a fairly reliable determination of exercise intensity and for predicting the level of lactate accumulation, and on this basis, determining the direction of the exercise and normalizing the training load.
本研究的目的是寻找脉冲债务积累强度(PDАI)与不同持续时间的限制性循环运动期间血液中需氧量形成速率和乳酸积累的关系。方法:14名自行车运动员(第一类,20±3岁,MОC - 52.9±5.10 ml / min / kg),在固定时间10、30、60、120、360、1800 s的不同天数进行一系列最大功率的自行车运动。根据5分钟恢复(减去开始前的HR水平)和运动时间的脉搏和,计算每个受试者所有运动的脉搏债积累强度。计算血乳酸浓度积累速率(SNCL)和需氧量形成速率(OCR)。结果:SOCS、SNCL、PDАI与运动时间(分别为r2 = 0.84、r2 = 0.91、r2 = 0.96, p < 0.05)和相对运动功率(分别为r2 = 0.80、r2 = 0.86、r2 = 0.90, p < 0.05)呈密切的非线性关系。INPD与SRCS、SNCL关系密切(r2 = 0.80, r2 = 0.94, p < 0.05)。结论:本研究结果使INPD心率指标能够较为可靠地确定运动强度,预测乳酸积累水平,并在此基础上确定运动方向,规范训练负荷。
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引用次数: 0
Features of carnitine metabolism in young athletes 年轻运动员肉碱代谢的特点
Pub Date : 2022-12-21 DOI: 10.47529/2223-2524.2022.4.8
A. Samoilov, A. Zholinsky, N. Rylova, I. Bolshakov
Objective: to study the indicators of carnitine metabolism in young athletes of various specializations.Materials and methods: This study involved 46 people with different levels of physical activity aged 15 to 18 years. The first group consisted of 18 girls professionally involved in field hockey (mean age, 16.17 ± 0.31 years). The second group included 21 swimmers (10 girls and 11 boys, mean age 17.00 ± 0.26 years). The control group included 7 young men with a standard mode of motor activity, not involved in sports (the age of the subjects was 16 years). In the course of the study, the method of liquid tandem chromatography-mass spectrometry with ionization in an electrospray was used. The material for research is capillary blood. As a result of the analysis of the material, the concentrations of bound carnitine (acylcarnitines) and free carnitine were determined in µmol/l.Results: Comparative blood analysis between the three groups showed differences in free carnitine levels. It was shown that the concentration of free carnitine in the blood plasma of field hockey athletes was significantly lower than in the groups of swimmers and non-athletes (p < 0.001). At the same time, the values of indicators of bound carnitine did not differ significantly between all subjects. We also studied that the values of the carnitine coefficient were significantly higher in the group of hockey players compared to other groups (p < 0.001).Conclusion: The decrease in free carnitine levels in the group of hockey players is probably the result of long-term adaptation of the body to conditions in which glucose is the main energy substrate for working muscles. Further studies are needed to clarify the exact mechanisms of development of this phenomenon.
目的:研究不同专业青年运动员肉碱代谢指标。材料和方法:这项研究涉及46名年龄在15至18岁之间的人,他们有不同程度的体育锻炼。第一组为18名职业曲棍球运动员(平均年龄16.17±0.31岁)。第二组共21例,其中女生10例,男生11例,平均年龄(17.00±0.26)岁。对照组包括7名年轻男性,具有标准的运动模式,不参与体育运动(受试者年龄为16岁)。在研究过程中,采用了电喷雾电离液相串联色谱-质谱法。研究的材料是毛细血管血液。通过对材料的分析,以µmol/l为单位测定了结合肉碱(酰基肉碱)和游离肉碱的浓度。结果:三组血液对比分析显示游离肉碱水平存在差异。结果表明,曲棍球运动员血浆游离肉碱浓度显著低于游泳组和非运动员组(p < 0.001)。同时,结合肉碱的各项指标在所有受试者之间无显著差异。我们还研究了曲棍球运动员组的肉碱系数值明显高于其他组(p < 0.001)。结论:曲棍球运动员游离肉碱水平的下降可能是身体长期适应葡萄糖作为工作肌肉主要能量底物的条件的结果。需要进一步的研究来阐明这一现象发展的确切机制。
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引用次数: 0
The relationship between reaction to a moving object with concentrations of biogenic amines and kynematic-dynamic parameters of complex coordination movement in elite alpine skiers 优秀高山滑雪运动员对运动物体的反应与生物胺浓度与复杂协调运动动力学参数的关系
Pub Date : 2022-12-20 DOI: 10.47529/2223-2524.2022.3.3
A. Kryuchkov, A. M. Fedoseev, S. Missina, G. A. Dudko, E. Myakinchenko
Aim of the study: to identify mutual interaction between the reaction to a moving object with functional state of the central nervous system and kinematic-dynamic parameters of complex coordination movement.Materials and methods: 9 elite alpine skiers were participated in this study. Visual-motor coordination variables were assessed by computer complex for psychophysiological testing NS-Psychotest (Neurosoft, Russia). Dynamic parameters of complex coordination movement during counter movement jump were registered on the MuscleLab Force Plate (Ergotest Innovation A.S., Norway). Quantitation of hormones — adrenaline and noradrenaline as well as neurotransmitters — dopamine and serotonin in blood samples was performed using ultra-high performance liquid chromatograph combined with triple quadrupole mass analyzer LCMS-8060 (Shimadzu, Japan).Results: a significant negative relationship between the maximum output of motor efforts during counter movement jump, mean reaction time and the number of negative reactions recorded within visual-motor coordination testing was documented. A reliable positive relationship between excitation processes, jump power and jump time was established. Increases in noradrenaline and serotonin concentrations are positively associated with the number of accurate reactions, whereas dopamine level was positively correlated with jump altitude.Conclusion: the predominance of excitation over inhibition processes in the central nervous system had a positive effect on reducing the time spent on counter moving and increasing the maximum power of movement. As applied to alpine skiers we registered the following relationship: the higher the speeds of signal perception and muscle activation when solving a visual-motor task, the higher the power of working efforts, the shorter the time of the eccentric phase and total time spent on performing counter movement jump.
研究目的:识别中枢神经系统功能状态下对运动物体的反应与复杂协调运动的运动学-动力学参数之间的相互作用。材料与方法:选取9名优秀高山滑雪运动员为研究对象。视觉-运动协调变量采用NS-Psychotest (Neurosoft, Russia)心理生理测试计算机复合体进行评估。在MuscleLab力板(Ergotest Innovation A.S, Norway)上记录了反动作跳跃过程中复杂协调运动的动态参数。使用超高效液相色谱仪结合三重四极杆质谱分析仪LCMS-8060(岛津,日本)对血液样品中的激素-肾上腺素和去甲肾上腺素以及神经递质-多巴胺和血清素进行定量。结果:反动作跳跃时的最大运动力输出、平均反应时间与视觉运动协调测试中记录的负反应次数呈显著负相关。在激励过程、跳跃功率和跳跃时间之间建立了可靠的正相关关系。去甲肾上腺素和血清素浓度的增加与准确反应的数量呈正相关,而多巴胺水平与跳跃高度呈正相关。结论:中枢神经系统兴奋过程优于抑制过程对减少反运动时间和提高运动最大功率具有积极作用。对于高山滑雪者,我们发现了以下关系:在解决视觉运动任务时,信号感知速度和肌肉激活速度越快,工作功率越高,执行反动作跳跃所需的离心阶段时间和总时间越短。
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引用次数: 0
Shock wave therapy evaluation in the complex treatment of athletes with lateral epicondylitis 冲击波疗法在运动员外上髁炎综合治疗中的评价
Pub Date : 2022-12-20 DOI: 10.47529/2223-2524.2022.3.6
M. Ivanov, A. Samoylov, N. R. Zhestyankin
Objective: to evaluate the effectiveness of shock wave therapy in the complex treatment of athletes with lateral epicondylitis in comparison with standard methods of treatment.Materials and methods: On outpatient treatment in the period from 2019 to 2022. There were 168 athletes diagnosed with Lateral epicondylitis, including 78 women (46.4 %) and 90 men (53.6 %) aged 20 to 45 years. The mean age of the patients was 31.48 ± 6.72 years. The average duration of the disease was 33.68 ± 28.17 days. To achieve the set goals and objectives, a prospective randomized controlled clinical trial was conducted. We used a clinical examination of patients, a study of carpal dynamometry of the affected arm, an assessment of the level of pain and quality of life using the QuickDash and Patient-Rated Tennis Elbow Evaluation (PRTEE) scales, statistical research methods, as well as the use of standard treatment for lateral epicondylitis and radial shock wave therapy with an assessment of effectiveness one month after treatment.Results: shock wave therapy in the complex treatment of athletes with lateral epicondylitis, compared with standard methods of treatment, improved the quality of life and reduced pain three weeks after the start of treatment and has a more pronounced effect in the long term (p < 0.05); allowed to reduce the intensity of the signal from the bone tissue (trabecular edema) according to the results of magnetic resonance imaging.Conclusion: the expediency of using shock wave therapy in the complex treatment of athletes with lateral epicondylitis is substantiated, which makes it possible to recommend its use in practical healthcare.
目的:评价冲击波治疗在运动员外上髁炎综合治疗中的效果,并与标准治疗方法进行比较。材料与方法:2019 - 2022年门诊治疗情况。诊断为外上髁炎的运动员168例,其中女性78例(46.4%),男性90例(53.6%),年龄在20 ~ 45岁之间。患者平均年龄31.48±6.72岁。病程平均为33.68±28.17 d。为了达到既定的目标和目的,进行了一项前瞻性随机对照临床试验。我们对患者进行了临床检查,研究了受影响手臂的腕动力测量,使用QuickDash和患者评定网球肘评估(PRTEE)量表评估疼痛水平和生活质量,统计研究方法,以及使用标准治疗外上髁炎和桡骨冲击波治疗,并在治疗后一个月评估有效性。结果:冲击波疗法在运动员外上髁炎的综合治疗中,与标准治疗方法相比,在治疗开始后3周改善了生活质量,减轻了疼痛,长期效果更显著(p < 0.05);允许根据磁共振成像结果降低骨组织(小梁水肿)信号的强度。结论:冲击波疗法在运动员外上髁炎综合治疗中的有效性得到证实,有可能在实际医疗中推广应用。
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引用次数: 0
The combination of traditional cardiorespiratory markers during treadmill testing “to failure” in athletes, depending on professional activity 在运动员的跑步机测试中,传统心肺指标的组合“到失败”取决于专业活动
Pub Date : 2022-12-20 DOI: 10.47529/2223-2524.2022.3.5
V. Pustovoyt, E. I. Balakin, A. V. Khan, A. A. Murtazin, N. F. Maksjutov, P. S. Merkulova, K. A. Kubyshev
Exercise tolerance test with the use of the spiroergometry technique is a reliable diagnostic method which provides objective information about cardiorespiratory system condition when performing physical activity. Both new and traditional, well-proven cardiorespiratory markers obtained in the process of treadmill testing “to failure”, are described in this article. The nature of the influence of physical exertion on the indicators of cardiorespiratory system functional activity is presented. The interpretation for planning and subsequent monitoring of the training process in athletes of various professional activities is proposed.
运动耐量试验结合肺活量测定技术是一种可靠的诊断方法,可提供运动时心肺系统状况的客观信息。本文描述了在跑步机测试“失败”过程中获得的新的和传统的、经过验证的心肺标志物。介绍了体力消耗对心肺系统功能活动指标影响的性质。提出了对各种专业活动运动员训练过程的规划和后续监测的解释。
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引用次数: 0
Psychological support of young sportsmen in powerlifting and weightlifting 青少年举重运动员的心理支持
Pub Date : 2022-11-29 DOI: 10.47529/2223-2524.2022.3.7
A. Berestyanaya, S. Filippova, A. N. Kornilov, A. P. Oreshkov, V. Gorelik
The article is a research into psychological and pedagogic support of sportsmen aged 18–25 years old, with taking into account the gender factor, at the stages of training with the strength exercises. It states methods of psychical reserves mobilization of different psychophysical types of sportsmen, aimed at training process efficiency increase in order to reach high results during competitions.Introduction. The article is based at the methodic of classical development of sportsmen’s strength abilities in powerlifting in composition with psychological methods of psychological and pedagogic support (PPS) for increasing of reliability and successfulness of pre-competition training. PPS is considered to be a combination of targets, media, methods and circumstances of planning, realization and control of the process of formation, activation and optimization of sportsmen’s psychological processes, at the stages of preparing for competitions and participating in them. Research target. Theoretical elaboration and experimental substantiation of the methodic of PPS training preparation for the competitions when going in for powerlifting and weightlifting.Materials and methods. The method of control test, pedagogic experiment (PE), fitness tests, anthropometrical methods, psychological development of personality methods, mathematical statistics methods. The research was being performed during five weeks (2020-02-01–2020-03-15). During the pedagogical experiment (PE), strength trainings were based at five-week cycle by B.I. Sheyko, which is equal to one pre-competition mesocycle. Sportsmen aged 18–25 years old formed two groups of 20 persons each: control group (CG) and experimental group (EG), divided [inside] by the gender factor. CG and EG were training with the classical powerlifting methodic, in EG it was supplemented with psychological processes optimization methods.The methodic of PPS preparation for a competition included: learning of goal-setting, forming of readiness for competitions, learning of coping, activation of motivation processes, increase of self-control and of psychoregulation of behavior and sport activity.Results. The authors elaborated five-week mesocycle (medium cycle) of training for powerlifters aged 18-25 years old. The forming impact of the complex of PPS methods in EG caused certain growth of strength results in EG at the end of PE: each of CG sportswomen lifted 142.5 kg in the sum of three-lift, CG sportsmen — 215 kg. In EG the result of sportswomen is 190 kg, the result of sportsmen is 250 kg. The growth, when comparing EG and CG, was 57.5 kg for sportswomen and 35 kg for sportsmen in favour of RG with PPS. Psychophysical types of young powerlifters, who need psychological and pedagogic support, were identified, recovery measures for psychological preparation were proposed.Conclusion. PPS in the complex with strength trainings caused certain growth of strength indexes of powerlifters aged 18–25 years old, with taking into ac
本文对18-25岁运动员在力量训练阶段的心理和教学支持进行了研究,并考虑了性别因素。阐述了不同心理物理类型运动员的心理储备动员方法,旨在提高训练过程的效率,从而在比赛中取得较高的成绩。本文以举重运动员力量能力的经典发展方法为基础,运用心理支持和教学支持(PPS)的心理学方法,提高赛前训练的可靠性和成功率。PPS被认为是运动员心理过程在备战和参加比赛阶段的形成、激活和优化过程的规划、实现和控制过程的目标、媒介、方法和环境的组合。研究的目标。对参加力量举重比赛前PPS训练准备方法的理论阐述与实验验证。材料和方法。方法有对照试验、教育学实验(PE)、体能测试、人体测量法、人格心理发展法、数理统计法等。研究为期五周(2020-02-01-2020-03-15)。在教学实验(PE)中,力量训练以bbi Sheyko的五周周期为基础,相当于一个赛前中间周期。18-25岁的运动员分为两组,每组20人:对照组(CG)和实验组(EG),按性别因素分为[内]。CG和EG均采用经典的力量举训练方法,EG中辅以心理过程优化方法。PPS竞赛准备的方法包括:目标设定的学习、竞赛准备的形成、应对的学习、动机过程的激活、自我控制的增强、行为和体育活动心理调节的增强。作者详细阐述了18-25岁力量举重运动员5周的中周期训练。PPS复合方法在EG中的形成影响,使EG在运动结束时的力量结果有一定的增长:CG运动员在三次举重中每人举起142.5 kg, CG运动员- 215 kg。在田径比赛中,女运动员的成绩是190公斤,男运动员的成绩是250公斤。当比较EG和CG时,女性运动员的增长为57.5公斤,男性运动员的增长为35公斤,有利于RG和PPS。对青少年力量举重运动员需要心理和教学支持的心理物理类型进行了识别,并提出了心理准备的康复措施。在考虑性别因素的情况下,PPS与力量训练相结合,可使18-25岁的举重运动员力量指标有一定的提高。女生的力量指标比男生进步1、8 ~ 2倍。在进行PPS训练时,必须考虑到力量举重运动员的性别特点,以及心理准备方法对男孩和女孩的不同影响。
{"title":"Psychological support of young sportsmen in powerlifting and weightlifting","authors":"A. Berestyanaya, S. Filippova, A. N. Kornilov, A. P. Oreshkov, V. Gorelik","doi":"10.47529/2223-2524.2022.3.7","DOIUrl":"https://doi.org/10.47529/2223-2524.2022.3.7","url":null,"abstract":"The article is a research into psychological and pedagogic support of sportsmen aged 18–25 years old, with taking into account the gender factor, at the stages of training with the strength exercises. It states methods of psychical reserves mobilization of different psychophysical types of sportsmen, aimed at training process efficiency increase in order to reach high results during competitions.Introduction. The article is based at the methodic of classical development of sportsmen’s strength abilities in powerlifting in composition with psychological methods of psychological and pedagogic support (PPS) for increasing of reliability and successfulness of pre-competition training. PPS is considered to be a combination of targets, media, methods and circumstances of planning, realization and control of the process of formation, activation and optimization of sportsmen’s psychological processes, at the stages of preparing for competitions and participating in them. Research target. Theoretical elaboration and experimental substantiation of the methodic of PPS training preparation for the competitions when going in for powerlifting and weightlifting.Materials and methods. The method of control test, pedagogic experiment (PE), fitness tests, anthropometrical methods, psychological development of personality methods, mathematical statistics methods. The research was being performed during five weeks (2020-02-01–2020-03-15). During the pedagogical experiment (PE), strength trainings were based at five-week cycle by B.I. Sheyko, which is equal to one pre-competition mesocycle. Sportsmen aged 18–25 years old formed two groups of 20 persons each: control group (CG) and experimental group (EG), divided [inside] by the gender factor. CG and EG were training with the classical powerlifting methodic, in EG it was supplemented with psychological processes optimization methods.The methodic of PPS preparation for a competition included: learning of goal-setting, forming of readiness for competitions, learning of coping, activation of motivation processes, increase of self-control and of psychoregulation of behavior and sport activity.Results. The authors elaborated five-week mesocycle (medium cycle) of training for powerlifters aged 18-25 years old. The forming impact of the complex of PPS methods in EG caused certain growth of strength results in EG at the end of PE: each of CG sportswomen lifted 142.5 kg in the sum of three-lift, CG sportsmen — 215 kg. In EG the result of sportswomen is 190 kg, the result of sportsmen is 250 kg. The growth, when comparing EG and CG, was 57.5 kg for sportswomen and 35 kg for sportsmen in favour of RG with PPS. Psychophysical types of young powerlifters, who need psychological and pedagogic support, were identified, recovery measures for psychological preparation were proposed.Conclusion. PPS in the complex with strength trainings caused certain growth of strength indexes of powerlifters aged 18–25 years old, with taking into ac","PeriodicalId":309619,"journal":{"name":"Sports medicine: research and practice","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117007784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possibilities of echocardiographic screening in athletes. Part 1. Normal values 超声心动图筛查运动员的可能性。第1部分。正常的值
Pub Date : 2022-11-15 DOI: 10.47529/2223-2524.2022.3.8
A. Sharykin, V. Badtieva, Iu. M. Ivanova, D. M. Usmanov
Objective: assess the suitability of existing domestic and international recommendations for the use of echocardiography as a screening method for examining athletes; to select standards that characterize the heart in different sports, based on their own research.Materials and methods: a meta‑analysis of 38 domestic and foreign literature sources based on the results of an echocardiographic examination of athletes was carried out. The indicators of 2647 male athletes aged 16 to 45 years old, playing for the national teams of the city of Moscow and having passed an in‑depth medical examination at the Sports Medicine Clinic, were studied.Results: heart sizes in athletes differ slightly from population indicators, however, in 14–45% of cases they go beyond the reference values. In the absence of heart disease, the largest dimensions of the left ventricle (LV) are observed in endurance exercisers. At the same time, high functionality correlates with increased LV volume indexed by BCA (for EDV/BSA and VO2 AT r = 0.52, p < 0.05).Conclusion: echocardiographic screening of athletes allows obtaining sufficient information to identify congenital or pathology that has arisen during excessive training loads. As standards, it is advisable to use population indicators expressed in centile values.
目的:评估现有的国内和国际推荐使用超声心动图作为检查运动员的筛查方法的适用性;根据自己的研究,选择不同运动中心脏特征的标准。材料和方法:基于一名运动员超声心动图检查结果,对38篇国内外文献进行meta分析。对2647名16至45岁的莫斯科市国家队男子运动员的各项指标进行了研究,这些运动员在运动医学诊所接受了深入的体检。结果:运动员的心脏大小与人群指标略有不同,但有14-45%的运动员心脏大小超过参考值。在没有心脏病的情况下,耐力锻炼者的左心室(LV)尺寸最大。同时,高功能性与BCA指标的LV容积增加相关(EDV/BSA和VO2 At r = 0.52, p < 0.05)。结论:超声心动图筛查运动员可以获得足够的信息,以确定在过度训练负荷期间出现的先天性或病理。作为标准,建议使用以百分位数表示的人口指标。
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引用次数: 0
Approaches to the classification of sports disciplines, taking into account their influence on the biochemical profile of an athlete 体育学科分类的方法,考虑到它们对运动员生化特征的影响
Pub Date : 2022-11-03 DOI: 10.47529/2223-2524.2022.2.7
A. Zholinsky, Zh. V. Grishina, A. I. Kadykova, G. Makarova, R. Deev
There are many classifications of sports disciplines, which base on various approaches, which separately take into account the patterns of training activity, physiology, the risk of collision and injury, etc. In our opinion, it most fully reflects the specifics of sports changes that occur in the body of athletes under the influence of intense physical activity, at the level of biochemical processes. The classification of sports disciplines proposed by us takes into account the influence of the nature of the training process, the specifics of sports loads, the leading type of energy supply of sports work on the biochemical profile of an athlete, which makes it possible to identify the key features that occur in the body of an athlete under the influence of a specific load.
体育学科有许多分类,这些分类基于不同的方法,分别考虑到训练活动的模式、生理学、碰撞和受伤的风险等。我们认为,它最充分地反映了运动员在剧烈体育活动的影响下,在生化过程水平上发生的运动变化的特殊性。我们提出的运动学科分类考虑到训练过程的性质、运动负荷的具体情况、运动工作的主要能量供应类型对运动员生化特征的影响,这使得有可能确定运动员在特定负荷影响下身体中发生的关键特征。
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引用次数: 0
Problems of semiotics of diseases of the Achilles tendon in clinical and educational aspects 跟腱疾病的符号学在临床和教育方面的问题
Pub Date : 2022-11-03 DOI: 10.47529/2223-2524.2022.2.9
E. Sorokin, А. P. Sereda, E. Pashkova, N. Konovalchuk, V. Fomichev, D. Chugaev, K. Demyanova, D. Shulepov
Achilles tendon disorders are represented by a big group of heterogenous in etiology and pathogenesis conditions, that are quite frequent in patients of various age groups. The diversity of this group of orthopedic disorders and the insufficient information provided on this topic in specialized literature leads to confusion in terminology, which, in turn, leads to misunderstanding the essence of patient’s problem and to mistakes in treatment of such patients.We carried out a content-analysis of contemporary Russian and foreign literature to summarize the existing knowledge and to create the universal nomenclature of the studied pathological conditions for further correct understanding of the problem and creation of classification of disorders and injuries of Achilles tendon.
跟腱疾病在病因病机条件上具有很大的异质性,在各个年龄组的患者中都很常见。这组骨科疾病的多样性和专业文献中关于这一主题的信息不足导致了术语的混淆,这反过来又导致了对患者问题本质的误解和对这类患者的治疗错误。我们对当代俄罗斯和国外文献进行了内容分析,总结现有知识,并为所研究的病理条件创建通用的命名法,以进一步正确认识问题并创建跟腱疾病和损伤的分类。
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引用次数: 1
Comparison of microRNA expression profiles of athletes involved in endurance sports and non-athletic volunteers using a hypoxia signaling pathway panel 使用缺氧信号通路面板比较耐力运动运动员和非运动志愿者的microRNA表达谱
Pub Date : 2022-11-03 DOI: 10.47529/2223-2524.2022.2.10
I. Pronina, P. Postnikov, V. I. Pavlov, Z. G. Ordzhonikidze
In recent years, interest in the search for new potential molecular biomarkers to assess the effectiveness of the training process in elite sports, various pathologies caused by overload, and abuse of prohibited substances has reached an unprecedented level. MicroRNAs that regulate the processes of metabolism, differentiation, proliferation, and apoptosis of cells at the post-transcriptional level are the most valuable candidates for use in this regard. They are found in all biological fluids of the human body, are stable during long-term storage and resistant to changes in environmental conditions. It is known that changes in the miRNA expression profile are closely associated with physical activity, as well as with the administration of recombinant hormones, erythropoiesis-stimulating agents, and other substances and methods that improve sports performance, which are prohibited by the World Anti-Doping Agency (WADA).Objective: In this study, plasma samples from athletes involved in endurance sports (race walking) and non-athletic volunteers were analyzed using a hypoxia signaling pathway panel to identify hypoxia candidate markers.Materials and methods: Expression profiles of plasma circulating miRNAs were assessed by reverse transcription followed by real-time quantitative polymerase chain reaction (RT Q-PCR). The obtained data were subjected to statistical processing using the CFX Manager Software v3.1 program.Results: Three potential microRNA markers were identified: hsa-miR-210-3p, hsa-miR-320a and hsa-miR-935 (increased in athletes by 61.6 times, 51.8 and 41.0 times, respectively) — of physiological response to the training, load, which may be associated with the emergence of hypoxia during endurance training.Conclusion: We have obtained preliminary data on differences in the expression profiles of circulating miRNAs in healthy non-athletic volunteers and professional athletes in the out-of-competition period. In the future, it is planned to expand the sample of studied blood plasma samples and compare the expression profiles of circulating microRNAs in athletes in competition and out-of-competition periods, as well as to compare the expression profiles of circulating microRNAs during aerobic and anaerobic loads. In addition, it is of interest to analyze changes in the expression levels of circulating miRNAs when using hypoxia mimetics applied to improve sports performance.
近年来,人们对寻找新的潜在分子生物标志物来评估精英运动训练过程的有效性、过载引起的各种病理和滥用违禁物质的兴趣达到了前所未有的水平。在转录后水平调控细胞代谢、分化、增殖和凋亡过程的microrna是在这方面最有价值的候选者。它们存在于人体的所有生物体液中,在长期储存期间是稳定的,并且对环境条件的变化具有抵抗力。众所周知,miRNA表达谱的变化与身体活动密切相关,也与重组激素、促红细胞生成剂和其他提高运动成绩的物质和方法的使用密切相关,这些物质和方法被世界反兴奋剂机构(WADA)禁止。目的:在本研究中,使用缺氧信号通路面板对耐力运动(竞走)运动员和非运动志愿者的血浆样本进行分析,以确定缺氧候选标志物。材料和方法:采用逆转录法和实时定量聚合酶链反应(RT Q-PCR)检测血浆循环mirna的表达谱。使用CFX Manager Software v3.1程序对获得的数据进行统计处理。结果:确定了三种潜在的microRNA标记物:hsa-miR-210-3p, hsa-miR-320a和hsa-miR-935(在运动员中分别增加了61.6倍,51.8倍和41.0倍)-对训练,负荷的生理反应,这可能与耐力训练期间缺氧的出现有关。结论:我们获得了健康的非运动志愿者和职业运动员在非竞赛期循环mirna表达谱差异的初步数据。在未来,我们计划扩大研究的血浆样本,比较运动员在比赛和非比赛期间循环microrna的表达谱,以及比较有氧和无氧负荷时循环microrna的表达谱。此外,当使用缺氧模拟物来提高运动成绩时,分析循环mirna表达水平的变化也是很有意义的。
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引用次数: 1
期刊
Sports medicine: research and practice
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