This study aimed to examine causal relationships between bicultural identity, acculturative stress, and subjective well-being among multicultural adolescents. Secondary longitudinal data that were obtained from 1,635 multicultural adolescents were analyzed. The results showed that bicultural identity had a positive effect on psychological well-being and a negative impact on acculturative stress; in addition, greater acculturative stress was associated with lower psychological well-being. Finally, bicultural identity indirectly affected psychological well-being by mediating the effects of acculturative stress. These findings underscore the need to facilitate the adaptation of multicultural adolescents by reducing acculturative stress and promoting bicultural acceptance in educational institutions.
{"title":"The relationship between bicultural identity, acculturative stress and psychological well-being in multicultural adolescents: Verification using multivariate latent growth modeling.","authors":"S. Bae","doi":"10.1002/smi.2912","DOIUrl":"https://doi.org/10.1002/smi.2912","url":null,"abstract":"This study aimed to examine causal relationships between bicultural identity, acculturative stress, and subjective well-being among multicultural adolescents. Secondary longitudinal data that were obtained from 1,635 multicultural adolescents were analyzed. The results showed that bicultural identity had a positive effect on psychological well-being and a negative impact on acculturative stress; in addition, greater acculturative stress was associated with lower psychological well-being. Finally, bicultural identity indirectly affected psychological well-being by mediating the effects of acculturative stress. These findings underscore the need to facilitate the adaptation of multicultural adolescents by reducing acculturative stress and promoting bicultural acceptance in educational institutions.","PeriodicalId":309674,"journal":{"name":"Stress and health : journal of the International Society for the Investigation of Stress","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117293144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. N. de Souza-Talarico, C. Suemoto, I. Santos, R. Griep, S. Yamaguti, P. Lotufo, I. Benseñor
Assessing risk factors exposure, such as stress in the workplace during adulthood, may contribute to detecting early signs of cognitive impairment in order to implement effective actions to improve brain health and consequently to decrease cognitive disorders later in life. In this cross-sectional study, we aimed to investigate whether work-related stress is associated with low cognitive performance in middle-aged adults from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), and whether social support mediates this relationship. Work-related stress was evaluated in 9,969 workers using the Demand-Control-Support Questionnaire (DCSQ). Cognitive function was assessed using the verbal fluency, trail-making version B, and delayed recall word tests (DRWT). Work-related stress was associated with lower performance on the delayed recall, verbal fluency, and executive function tests in middle-aged adults. Social support may mediate the association between work demands and cognitive performance. These findings support that work-related stress is associated with cognitive performance during adulthood.
{"title":"Work-related stress and cognitive performance among middle-aged adults: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).","authors":"J. N. de Souza-Talarico, C. Suemoto, I. Santos, R. Griep, S. Yamaguti, P. Lotufo, I. Benseñor","doi":"10.1002/smi.2906","DOIUrl":"https://doi.org/10.1002/smi.2906","url":null,"abstract":"Assessing risk factors exposure, such as stress in the workplace during adulthood, may contribute to detecting early signs of cognitive impairment in order to implement effective actions to improve brain health and consequently to decrease cognitive disorders later in life. In this cross-sectional study, we aimed to investigate whether work-related stress is associated with low cognitive performance in middle-aged adults from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), and whether social support mediates this relationship. Work-related stress was evaluated in 9,969 workers using the Demand-Control-Support Questionnaire (DCSQ). Cognitive function was assessed using the verbal fluency, trail-making version B, and delayed recall word tests (DRWT). Work-related stress was associated with lower performance on the delayed recall, verbal fluency, and executive function tests in middle-aged adults. Social support may mediate the association between work demands and cognitive performance. These findings support that work-related stress is associated with cognitive performance during adulthood.","PeriodicalId":309674,"journal":{"name":"Stress and health : journal of the International Society for the Investigation of Stress","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114780291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabelle Leboeuf, Julianna Mahanga, S. Rusinek, P. Delamillieure, F. Gheysen, Eva Andreotti, P. Antoine
BACKGROUND Self-criticism and self-reassurance are internal processes of self-to-self relating that have received increasing attention in psychology. The Forms of Self-Criticizing/Attacking & Self-reassuring Scale (FSCRS), which was first studied by Gilbert, Clarke, Hempel, Miles, and Irons (2004) is a self-report instrument that has been used in various populations and has shown satisfactory reliability. The goal of this work is to explore the psychometric properties of a French version of the scale in a large non-clinical sample. METHOD Data from 285 nonclinical participants were analyzed. RESULTS Confirmatory factor analysis indicated an acceptable to good fit of the FSCRS items to a three-factor model. Good internal consistency and convergent validity were found. CONCLUSIONS The French validation results corroborate previous findings in a non-clinical population and confirm that the French version of the FSCRS is a robust and reliable instrument.
自我批评和自我保证是一种自我与自我联系的内在过程，在心理学中受到越来越多的关注。自我批评/攻击和自我安慰量表(FSCRS)由Gilbert, Clarke, Hempel, Miles, and Irons(2004)首次研究，是一种自我报告工具，已在各种人群中使用，并显示出令人满意的可靠性。这项工作的目的是在一个大的非临床样本中探索法语版量表的心理测量特性。方法对285名非临床参与者的数据进行分析。结果验证性因子分析表明，FSCRS项目与三因素模型拟合良好。具有良好的内部一致性和收敛效度。结论:法国的验证结果证实了之前在非临床人群中的发现，并证实了法国版本的FSCRS是一种稳健可靠的工具。
{"title":"Validation of the French version of the Forms of Self-Criticizing/Attacking and Self-Reassuring Scale (FSCRS).","authors":"Isabelle Leboeuf, Julianna Mahanga, S. Rusinek, P. Delamillieure, F. Gheysen, Eva Andreotti, P. Antoine","doi":"10.1002/smi.2909","DOIUrl":"https://doi.org/10.1002/smi.2909","url":null,"abstract":"BACKGROUND\u0000Self-criticism and self-reassurance are internal processes of self-to-self relating that have received increasing attention in psychology. The Forms of Self-Criticizing/Attacking & Self-reassuring Scale (FSCRS), which was first studied by Gilbert, Clarke, Hempel, Miles, and Irons (2004) is a self-report instrument that has been used in various populations and has shown satisfactory reliability. The goal of this work is to explore the psychometric properties of a French version of the scale in a large non-clinical sample.\u0000\u0000\u0000METHOD\u0000Data from 285 nonclinical participants were analyzed.\u0000\u0000\u0000RESULTS\u0000Confirmatory factor analysis indicated an acceptable to good fit of the FSCRS items to a three-factor model. Good internal consistency and convergent validity were found.\u0000\u0000\u0000CONCLUSIONS\u0000The French validation results corroborate previous findings in a non-clinical population and confirm that the French version of the FSCRS is a robust and reliable instrument.","PeriodicalId":309674,"journal":{"name":"Stress and health : journal of the International Society for the Investigation of Stress","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129182788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The objective of this study was to examine the association of life events stressors with risk of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) by using the multilevel sample from the 2007 Los Angeles Mommy and Baby (LAMB)survey. Four multilevel logistic regression models were applied while accounting for the multilevel design of the LAMB study. The following demographic variables were used as covariates: maternal age, race/ethnicity, maternal educational attainment, household income level in the previous year,physical exercise and pre-pregnancy bodyweight status. The scale for total number of stressors was positively associated with GDM in Model 1,but the association did not reach the significance threshold of 0.05. In Model 2 where four specific domains of stressors (financial,traumatic,spousal and emotional stressors)were used as the key exposure variables, the number of financial stressors during pregnancy was significantly associated with a higher risk of GDM. The scale for total number of stressors was associated with HDP in Model 3. Experience of financial stressors during pregnancy was significantly associated with a higher risk of HDP in Model 4.In conclusion, exposure to higher number of financial stressors was associated with an elevated risk of GDM and HDP.
{"title":"Stressful Life events, hypertensive disorders and high blood sugar during pregnancy.","authors":"Liwei Chen, Lu Shi, M. Chao, Xia Tongd, Fan Wang","doi":"10.1002/smi.2911","DOIUrl":"https://doi.org/10.1002/smi.2911","url":null,"abstract":"The objective of this study was to examine the association of life events stressors with risk of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) by using the multilevel sample from the 2007 Los Angeles Mommy and Baby (LAMB)survey. Four multilevel logistic regression models were applied while accounting for the multilevel design of the LAMB study. The following demographic variables were used as covariates: maternal age, race/ethnicity, maternal educational attainment, household income level in the previous year,physical exercise and pre-pregnancy bodyweight status. The scale for total number of stressors was positively associated with GDM in Model 1,but the association did not reach the significance threshold of 0.05. In Model 2 where four specific domains of stressors (financial,traumatic,spousal and emotional stressors)were used as the key exposure variables, the number of financial stressors during pregnancy was significantly associated with a higher risk of GDM. The scale for total number of stressors was associated with HDP in Model 3. Experience of financial stressors during pregnancy was significantly associated with a higher risk of HDP in Model 4.In conclusion, exposure to higher number of financial stressors was associated with an elevated risk of GDM and HDP.","PeriodicalId":309674,"journal":{"name":"Stress and health : journal of the International Society for the Investigation of Stress","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134295600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Moirasgenti, K. Doulougeri, E. Panagopoulou, T. Theodoridis
Our study aimed to assess the impact of maternal psychological stress on the immunological components of breast milk. Eighty-nine women participated in the study. We assessed general stress, postpartum specific stress, negative affectivity, salivary cortisol of mother and sIgA levels of breast milk 4-6 weeks after delivery. Controlling for the effects of women's age, weight, number and duration of feedings postpartum, specific stress was related to reduced sIgA concentration (R2 = .206, Beta = -.275, p = .020). This study suggests that the established link between psychological stress and immunity may also extend to the immunity of the newborn by reducing the immunological benefits of breast milk. It also suggests that breastfeeding might be a potential mechanism of the relationship between maternal stress and the health of the offspring. Findings highlight the need for interventions addressing women during the postpartum period, in order to ensure the mother' s well-being and the infant' s optimal development.
我们的研究旨在评估母亲心理压力对母乳免疫成分的影响。89名女性参与了这项研究。我们评估了一般压力、产后特定压力、消极情绪、母亲唾液皮质醇和产后4-6周母乳sIgA水平。在控制了年龄、体重、产后喂养次数和持续时间的影响后，特定应激与sIgA浓度降低相关(R2 = .206, Beta = -)。275, p = 0.020)。这项研究表明，心理压力和免疫力之间的既定联系也可能通过降低母乳的免疫益处而扩展到新生儿的免疫力。这也表明母乳喂养可能是母亲压力和后代健康之间关系的潜在机制。研究结果强调需要干预解决妇女在产后期间，以确保母亲的福祉和婴儿的最佳发展。
{"title":"Psychological stress reduces the immunological benefits of breast milk.","authors":"Maria Moirasgenti, K. Doulougeri, E. Panagopoulou, T. Theodoridis","doi":"10.1002/smi.2903","DOIUrl":"https://doi.org/10.1002/smi.2903","url":null,"abstract":"Our study aimed to assess the impact of maternal psychological stress on the immunological components of breast milk. Eighty-nine women participated in the study. We assessed general stress, postpartum specific stress, negative affectivity, salivary cortisol of mother and sIgA levels of breast milk 4-6 weeks after delivery. Controlling for the effects of women's age, weight, number and duration of feedings postpartum, specific stress was related to reduced sIgA concentration (R2 = .206, Beta = -.275, p = .020). This study suggests that the established link between psychological stress and immunity may also extend to the immunity of the newborn by reducing the immunological benefits of breast milk. It also suggests that breastfeeding might be a potential mechanism of the relationship between maternal stress and the health of the offspring. Findings highlight the need for interventions addressing women during the postpartum period, in order to ensure the mother' s well-being and the infant' s optimal development.","PeriodicalId":309674,"journal":{"name":"Stress and health : journal of the International Society for the Investigation of Stress","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125775963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In China, nursing is a profession with considerable stress, which may cause both physiological and psychological problems. The present study conducted a cross-temporal meta-analysis of 244 papers using the Symptom Checklist 90 (SCL-90) to investigate the changes in the mental health level of Chinese nurses (N = 71,286) from 1998 to 2016. Results showed that: (1) Relationships between scores of all 9 types of mental problems in the SCL-90 and year were significantly positive, indicating that the mental health level of nurses decreased steadily in the past 19 years. (2) Relationships between three social indicators (patient-to-nurse ratio, unemployment rate and divorce rate) and scores of all 9 types of mental problems in the SCL-90 were significantly positive, suggesting that the increase in these social indicators may be responsible for the decrease in Chinese nurses' mental health level.
{"title":"Changes in Chinese Nurses' Mental Health During 1998-2016: A Cross-Temporal Meta-Analysis.","authors":"Sufei Xin, Wenyuan Jiang, Ziqiang Xin","doi":"10.1002/smi.2907","DOIUrl":"https://doi.org/10.1002/smi.2907","url":null,"abstract":"In China, nursing is a profession with considerable stress, which may cause both physiological and psychological problems. The present study conducted a cross-temporal meta-analysis of 244 papers using the Symptom Checklist 90 (SCL-90) to investigate the changes in the mental health level of Chinese nurses (N = 71,286) from 1998 to 2016. Results showed that: (1) Relationships between scores of all 9 types of mental problems in the SCL-90 and year were significantly positive, indicating that the mental health level of nurses decreased steadily in the past 19 years. (2) Relationships between three social indicators (patient-to-nurse ratio, unemployment rate and divorce rate) and scores of all 9 types of mental problems in the SCL-90 were significantly positive, suggesting that the increase in these social indicators may be responsible for the decrease in Chinese nurses' mental health level.","PeriodicalId":309674,"journal":{"name":"Stress and health : journal of the International Society for the Investigation of Stress","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124406203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. McLinton, A. Afsharian, M. Dollard, Michelle R. Tuckey
Little is known about how safety climates concerning physical safety and psychosocial safety interact in the prediction of working conditions and subsequent worker health. Frontline healthcare was selected as the setting for this study on the dynamic interplay between physical and psychosocial safety climates because of a recent call for attention to working conditions in this industry. Poor safety climates for healthcare workers spill over into adverse outcomes for worker health, and when workers are compromised then so too is their provision of quality patient care. We developed an integrated model of the relationships between psychosocial and physical safety climates, working conditions, and health and safety outcomes. A multilevel model was tested (N=463 workers nested within n=60 teams), and lagged analysis was conducted across four time points, each six months apart. The combination of safety climates significantly predict objective outcomes from hospital safety system records on staff accidents, absence, and patient incidents (quality of care), suggesting a dynamic interplay in the prediction of impacts on the worker, organisation, and end-user. Integrated physical and psychosocial safety climate measures can be incorporated into hospital OHS reporting and response systems as effective lead indicators and key performance metrics for work health and safety.
{"title":"The dynamic interplay of physical and psychosocial safety climates in frontline healthcare.","authors":"S. McLinton, A. Afsharian, M. Dollard, Michelle R. Tuckey","doi":"10.1002/smi.2898","DOIUrl":"https://doi.org/10.1002/smi.2898","url":null,"abstract":"Little is known about how safety climates concerning physical safety and psychosocial safety interact in the prediction of working conditions and subsequent worker health. Frontline healthcare was selected as the setting for this study on the dynamic interplay between physical and psychosocial safety climates because of a recent call for attention to working conditions in this industry. Poor safety climates for healthcare workers spill over into adverse outcomes for worker health, and when workers are compromised then so too is their provision of quality patient care. We developed an integrated model of the relationships between psychosocial and physical safety climates, working conditions, and health and safety outcomes. A multilevel model was tested (N=463 workers nested within n=60 teams), and lagged analysis was conducted across four time points, each six months apart. The combination of safety climates significantly predict objective outcomes from hospital safety system records on staff accidents, absence, and patient incidents (quality of care), suggesting a dynamic interplay in the prediction of impacts on the worker, organisation, and end-user. Integrated physical and psychosocial safety climate measures can be incorporated into hospital OHS reporting and response systems as effective lead indicators and key performance metrics for work health and safety.","PeriodicalId":309674,"journal":{"name":"Stress and health : journal of the International Society for the Investigation of Stress","volume":"31 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114093908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Casagrande, Ilaria Boncompagni, A. Mingarelli, F. Favieri, G. Forte, Rosanna Germanò, G. Germano, Angela Guarino
The strategies that people usually use to cope with stressful events, i.e., their coping style, may affect blood pressure and cardiovascular functioning. Generally, hypertension is positively associated with emotion-oriented, maladaptive coping strategies, and negatively related to task-focused coping styles, but no study has investigated the relationship between coping strategies and the severity of hypertension. This study aimed to assess whether the severity of cardiovascular disorders was associated with specific coping strategies. Participants were selected from the Policlinico Umberto I of the University of Rome "Sapienza". The sample was divided into five groups:1) healthy people (n=190);2) people with untreated hypertension (n=232);3) people using anti-hypertensive medication (n=158);4) people using anti-hypertensive medication with uncontrolled hypertension (n=179);5) people suffering from both hypertension and heart diseases (N=192). Coping strategies were evaluated with the Coping Inventory for Stressful Situations. One-way ANCOVAs, considering Group as the independent variable and the coping strategies (task-focused, emotion-oriented and avoidance-oriented coping) as dependent variables, showed that individuals affected by both hypertension and heart diseases made less use of task-focused coping strategies than the other groups. These findings confirm the relationship between coping style and hypertension and highlight that patients with hypertension and heart diseases make less use of appropriate coping strategies.
{"title":"Coping styles in individuals with hypertension of varying severity.","authors":"M. Casagrande, Ilaria Boncompagni, A. Mingarelli, F. Favieri, G. Forte, Rosanna Germanò, G. Germano, Angela Guarino","doi":"10.1002/smi.2889","DOIUrl":"https://doi.org/10.1002/smi.2889","url":null,"abstract":"The strategies that people usually use to cope with stressful events, i.e., their coping style, may affect blood pressure and cardiovascular functioning. Generally, hypertension is positively associated with emotion-oriented, maladaptive coping strategies, and negatively related to task-focused coping styles, but no study has investigated the relationship between coping strategies and the severity of hypertension. This study aimed to assess whether the severity of cardiovascular disorders was associated with specific coping strategies. Participants were selected from the Policlinico Umberto I of the University of Rome \"Sapienza\". The sample was divided into five groups:1) healthy people (n=190);2) people with untreated hypertension (n=232);3) people using anti-hypertensive medication (n=158);4) people using anti-hypertensive medication with uncontrolled hypertension (n=179);5) people suffering from both hypertension and heart diseases (N=192). Coping strategies were evaluated with the Coping Inventory for Stressful Situations. One-way ANCOVAs, considering Group as the independent variable and the coping strategies (task-focused, emotion-oriented and avoidance-oriented coping) as dependent variables, showed that individuals affected by both hypertension and heart diseases made less use of task-focused coping strategies than the other groups. These findings confirm the relationship between coping style and hypertension and highlight that patients with hypertension and heart diseases make less use of appropriate coping strategies.","PeriodicalId":309674,"journal":{"name":"Stress and health : journal of the International Society for the Investigation of Stress","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115865651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The currently recognised mechanisms of the biology of cancer are not yet enough to explain the high incidence of the disease in industrialised countries. Survival and proliferation of cancer cells demand a well orchestrated combination of functional capabilities, or hallmarks, which requires complex signalling networks that often exceed the tumour boundaries. Based on latest research on environmental health, and aiming to provide cancer with a coherent set of organizing principles, we propose an integrative model of carcinogenesis founded on tumour growth activation by the central nervous system as an adaptive, allostatic response to both environmental and emotional challenges. In this way, chronicity of physical as well as psychological stressors may be directly involved in cancer genesis and progression, after an early inflammatory stage. The model also contemplates accidental activation of the tumour growth programme following direct DNA damage, but as a rare event that does not account for most cancers in humans. Bodily and cellular mechanisms designed to facilitate tumorigenesis may include exacerbation of the sympathetic activity, overexpression of membrane ion channels, promotion of selected mutations and methylations, degradation of the mitochondria, and reprogramming of adult stem cells.
{"title":"Tumour growth activation by the central nervous system--An integrative theory of cancer.","authors":"Alberto Recio","doi":"10.1002/smi.2890","DOIUrl":"https://doi.org/10.1002/smi.2890","url":null,"abstract":"The currently recognised mechanisms of the biology of cancer are not yet enough to explain the high incidence of the disease in industrialised countries. Survival and proliferation of cancer cells demand a well orchestrated combination of functional capabilities, or hallmarks, which requires complex signalling networks that often exceed the tumour boundaries. Based on latest research on environmental health, and aiming to provide cancer with a coherent set of organizing principles, we propose an integrative model of carcinogenesis founded on tumour growth activation by the central nervous system as an adaptive, allostatic response to both environmental and emotional challenges. In this way, chronicity of physical as well as psychological stressors may be directly involved in cancer genesis and progression, after an early inflammatory stage. The model also contemplates accidental activation of the tumour growth programme following direct DNA damage, but as a rare event that does not account for most cancers in humans. Bodily and cellular mechanisms designed to facilitate tumorigenesis may include exacerbation of the sympathetic activity, overexpression of membrane ion channels, promotion of selected mutations and methylations, degradation of the mitochondria, and reprogramming of adult stem cells.","PeriodicalId":309674,"journal":{"name":"Stress and health : journal of the International Society for the Investigation of Stress","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133982501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The association between chronic psychological stress and uterine fibroids (UFs) risk remains unclear. In this study, a meta-analysis of observational studies was performed to explore the reported association between them. A literature search was performed in PubMed, EMBASE and Web of Science to identify relevant published articles. A random-effect model was used to examine pooled odds ratio (OR) and 95% confidence interval (CI). Additionally, subgroup analyses and two-stage random-effect dose-response meta-analysis were performed. A total of 6 articles with 7 studies were included in this meta-analysis. For the highest vs. lowest category of chronic psychological stress, the pooled OR was 1.24 (95% CI, 1.15-1.34; P=0.000). Through subgroup analyses, we found a positive association between chronic psychological stress and UFs risk especially in non-Hispanic blacks studies (OR, 1.24, 95% CI 1.14-1.34, P=0.000). When evaluating for a dose-response we found a weak correlation between chronic psychological stress and UFs risk, especially for the severe (OR, 1.17, 95% CI 1.07-1.29) and very severe (OR, 1.23, 95% CI 1.07-1.41) categories. Our meta-analysis shows a statistically significant association between chronic psychological stress and UFs risk particularly for non-Hispanic blacks. Interventions aiming to reduce chronic psychological stress may be useful to decrease the prevalence of UFs.
慢性心理压力与子宫肌瘤(UFs)风险之间的关系尚不清楚。在本研究中，对观察性研究进行了荟萃分析，以探讨两者之间的关联。在PubMed, EMBASE和Web of Science中进行文献检索，以确定相关的已发表文章。采用随机效应模型检验合并优势比(OR)和95%置信区间(CI)。此外，还进行了亚组分析和两期随机效应剂量反应荟萃分析。本meta分析共纳入6篇文章和7项研究。对于慢性心理压力的最高和最低类别，合并OR为1.24 (95% CI, 1.15-1.34;P = 0.000)。通过亚组分析，我们发现慢性心理压力与UFs风险呈正相关，特别是在非西班牙裔黑人研究中(OR, 1.24, 95% CI 1.14-1.34, P=0.000)。在评估剂量反应时，我们发现慢性心理压力与UFs风险之间存在弱相关性，特别是在严重(OR, 1.17, 95% CI 1.07-1.29)和非常严重(OR, 1.23, 95% CI 1.07-1.41)类别中。我们的荟萃分析显示，慢性心理压力与UFs风险之间存在统计学上显著的关联，尤其是对非西班牙裔黑人而言。旨在减少慢性心理压力的干预措施可能有助于降低UFs的患病率。
{"title":"The association between chronic psychological stress and uterine fibroids risk: A meta-analysis of observational studies.","authors":"Hao Qin, Zhijuan Lin, E. Vásquez, Luo Xu","doi":"10.1002/smi.2895","DOIUrl":"https://doi.org/10.1002/smi.2895","url":null,"abstract":"The association between chronic psychological stress and uterine fibroids (UFs) risk remains unclear. In this study, a meta-analysis of observational studies was performed to explore the reported association between them. A literature search was performed in PubMed, EMBASE and Web of Science to identify relevant published articles. A random-effect model was used to examine pooled odds ratio (OR) and 95% confidence interval (CI). Additionally, subgroup analyses and two-stage random-effect dose-response meta-analysis were performed. A total of 6 articles with 7 studies were included in this meta-analysis. For the highest vs. lowest category of chronic psychological stress, the pooled OR was 1.24 (95% CI, 1.15-1.34; P=0.000). Through subgroup analyses, we found a positive association between chronic psychological stress and UFs risk especially in non-Hispanic blacks studies (OR, 1.24, 95% CI 1.14-1.34, P=0.000). When evaluating for a dose-response we found a weak correlation between chronic psychological stress and UFs risk, especially for the severe (OR, 1.17, 95% CI 1.07-1.29) and very severe (OR, 1.23, 95% CI 1.07-1.41) categories. Our meta-analysis shows a statistically significant association between chronic psychological stress and UFs risk particularly for non-Hispanic blacks. Interventions aiming to reduce chronic psychological stress may be useful to decrease the prevalence of UFs.","PeriodicalId":309674,"journal":{"name":"Stress and health : journal of the International Society for the Investigation of Stress","volume":"249 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115261782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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