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Shatavadhan Could Imply A New State of Consciousness 沙塔瓦丹可能意味着一种新的意识状态
Pub Date : 2023-11-30 DOI: 10.47363/jnrrr/2023(5)187
Surendra Singh Pokharna
Recent advances in neurosciences and an attempt to explain properties of consciousness has opened new frontiers to understand the properties of consciousness from various perspectives like quantum biology, neurophysiology, neuropsychology, quantum physics, computer science and several other disciplines. Here we describe a state of consciousness known as Shatvadhan. Shatvadhan in Jainism means one hundred states of extraordinary attention of the brain. In this state a person will listen or observe one hundred questions of different types from one hundred persons or more for over a period of say 2-3 hours without break and without using any paper or pen or electronic device. This is a demonstration of extraordinary memory to retain and recall questions and their answers in same sequence, reverse sequence or random sequences involving complex questions. This appears to represent a new state of consciousness which involves demonstration of extra ordinary memory, highly sequential ordering of memory, recalling, remembering sequences also in which memories of events are stored, simultaneous storing information from different sense organs and others. This also involves mathematical computations which are done in parts in different activities and simultaneous observations of pictures and listening of audio sounds. It appears that this process represents a new state of consciousness mostly found in saints who are highly advanced in the process of spiritual development. An analysis of this may provide new avenues of thought regarding storage and recalling mechanism of memory in the human brain. It may also involve non-local information transfer in the brain through quantum holography and similar mechanism.
神经科学的最新进展和解释意识特性的尝试开辟了从量子生物学、神经生理学、神经心理学、量子物理学、计算机科学等不同角度理解意识特性的新领域。在这里,我们描述一种被称为 "沙特瓦丹 "的意识状态。耆那教中的 "沙特瓦丹 "是指大脑超常注意力的一百种状态。在这种状态下,一个人可以听或观察一百个人或更多人提出的一百个不同类型的问题,持续时间超过两三个小时,中间不休息,也不使用任何纸、笔或电子设备。这是一种非凡记忆力的展示,它能保留和回忆问题及其答案,无论是同序、逆序还是涉及复杂问题的随机序列。这似乎代表了一种新的意识状态,包括展示超常记忆、记忆的高度顺序排列、回忆、记忆事件的顺序、同时存储来自不同感觉器官和其他器官的信息。这还包括在不同活动中分段进行的数学计算,以及同时观察图片和聆听声音。这一过程似乎代表了一种新的意识状态,多见于在精神发展过程中非常先进的圣人。对这一现象的分析可能会为人类大脑记忆的存储和回忆机制提供新的思路。它还可能涉及通过量子全息和类似机制在大脑中进行非局部信息传递。
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引用次数: 0
Wandering Through the Complex Mindset of Diabetic Foot Patients 漫游糖尿病足患者的复杂心态
Pub Date : 2023-07-31 DOI: 10.47363/jnrrr/2023(5)179
Sangeetha Kalabhairav, Sanjay Vaidya, Bharat Vatwani
When I saw Mrs. XYZ elderly female patient was brought to my OPD for my consultation by her family member. The patient was blissfully unaware of the fact that her foot wound had crawling maggots! Knowing that she was a diabetic for the last 15 years I decided to do a complete foot and limb evaluation as well a complete examination of the patient. I learnt that she was psychologically depressed.
当我看到XYZ女士时,她的家人把她带到我的门诊来咨询。这位病人幸而没有意识到她脚上的伤口上爬满了蛆!知道她患有糖尿病已经15年了,我决定做一个完整的足部和四肢评估以及对病人的全面检查。我了解到她有心理上的抑郁。
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引用次数: 0
Hyperbaric Oxygen and Outcomes Following the Brain Injury: A Systematic Review 高压氧和脑损伤后的预后:一项系统综述
Pub Date : 2023-07-31 DOI: 10.47363/jnrrr/2023(5)181
J. Iqbal, A. Naeem
Introduction: Hyperbaric oxygen therapy (HBO2) aims to address ischemia resulting from brain injury by subjecting patients to an atmosphere that dramatically raises the concentration of inspired oxygen (100% O2 at greater than 1 ATA). This results in elevated levels of oxygen in the plasma, which in turn boosts the delivery of oxygen for diffusion to the brain tissue.
高压氧治疗(HBO2)旨在通过使患者处于显著提高吸入氧浓度(大于1ata时100% O2)的大气中来解决脑损伤引起的缺血。这导致血浆中的氧含量升高,这反过来又促进了氧气向脑组织扩散的输送。
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引用次数: 0
Nonsyndromic Deafness Due to A Peculiar Compound Heterozygous Genotype of Novel Nonsense and Missense CEACAM16 Variants 一种新的无义和错义CEACAM16变体的特殊复合杂合基因型导致的非综合征性耳聋
Pub Date : 2023-07-31 DOI: 10.47363/jnrrr/2023(5)180
Enrique Nogueira, Beatriz delOlmo
A peculiar compound heterozygous genotype of gene CEACAM16 associated to non-syndromic hearing loss (NSHL) is reported, of two novel variants of terminal IgV-like domain N2 domain of CEACAM16, different in nature, nonsense p.Trp370Ter and missense p.Ala375Thr, that would have a pathogenic effect (hearing loss) by impairing the interaction of CEACAM16 with other prominent glycoproteins, mainly with TECTA and TECTB, introducing structural changes in the tectorial membrane (TM) of the organ of Corti.
报道了与非综合征性听力损失(NSHL)相关的CEACAM16基因的一种特殊的复合杂合基因型,是CEACAM16末端igv样结构域N2结构域的两个不同性质的新变体,无义p.Trp370Ter和错义p.Ala375Thr,它们可能通过破坏CEACAM16与其他主要糖蛋白(主要是TECTA和TECTB)的相互作用而具有致病性(听力损失)。引入Corti器官的覆盖膜(TM)的结构变化。
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引用次数: 0
Impact of Pelvic Alignment and Balance on Clinical and Community Walking Performance in Patients with Stroke: A Cross-sectional Study 骨盆对准和平衡对脑卒中患者临床和社区行走表现的影响:一项横断面研究
Pub Date : 2023-06-30 DOI: 10.47363/jnrrr/2023(5)177
Mishra Ashwini V
Background: Stroke is global health problem leading to significant mortality and morbidity. Patients with stroke has asymmetrical weight bearing and altered pelvic alignment. Low cardiovascular fitness affects the ability of walking and promote negative effect on overall health. So, the purpose was to analyse the influence of pelvic alignment on balance, and gait in patients with Stroke and its relation with walking performance.
背景:脑卒中是一个全球性的健康问题,导致严重的死亡率和发病率。中风患者有不对称的负重和骨盆排列改变。低心血管健康会影响步行能力,并对整体健康产生负面影响。因此,目的是分析骨盆对准对脑卒中患者平衡、步态的影响及其与行走性能的关系。
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引用次数: 0
Structural Fragility of Cerebral Aneurysms: A Comparative Analysis of Unruptured & Ruptured Aneurysms 脑动脉瘤的结构脆弱性:未破裂与破裂动脉瘤的比较分析
Pub Date : 2023-06-30 DOI: 10.47363/jnrrr/2023(5)175
Vivig Shantha Kumar
Ongoing studies to understand the mechanisms behind intracranial aneurysm (IA) pathogenesis characterize intracranial aneurysm as a maladaptive chronic inflammatory disease. An overwhelmingly large number of studies implicate inflammation as a crucial driver of aneurysmal growth and attendant rupture. The induction of aneurysmal formation begins with endothelial damage, which secondarily activates a progressive inflammatory response that compromises the structural integrity of the vessel wall. Pivotal consequences of this inflammatory response is a disintegration of the internal elastic lamina, myointimal hyperplasia, and vascular smooth muscle cell (vsmc) phenotypic modulation and subsequent apoptosis. Interestingly, analysis of gene expression profiles in patients with intracranial aneurysms commonly highlight a differential expression of genes related to inflammatory/immune responses, cell adhesion, and muscle contraction. A detailed understanding of intracranial aneurysmal pathogenesis may be possible by analyzing morphological differences in aneurysmal structure between unruptured and ruptured lesions. As such, in this review, we have attempted to understand sequential adaptations of the aneurysmal wall during various periods of growth, development and rupture by providing evidence for structural, genetic, and molecular differences between unruptured and ruptured intracranial aneurysm.
正在进行的研究了解颅内动脉瘤(IA)发病机制将颅内动脉瘤定性为一种适应不良的慢性炎症性疾病。绝大多数的研究表明,炎症是动脉瘤生长和破裂的关键驱动因素。动脉瘤形成的诱导始于内皮损伤,其继发性激活进行性炎症反应,损害血管壁的结构完整性。这种炎症反应的关键后果是内部弹性层的解体,肌内膜增生,血管平滑肌细胞(vsmc)表型调节和随后的细胞凋亡。有趣的是,对颅内动脉瘤患者基因表达谱的分析通常强调了与炎症/免疫反应、细胞粘附和肌肉收缩相关的基因的差异表达。通过分析未破裂和破裂病变之间动脉瘤结构的形态学差异,可以详细了解颅内动脉瘤的发病机制。因此,在这篇综述中,我们试图通过提供未破裂和破裂颅内动脉瘤之间结构、遗传和分子差异的证据来了解动脉瘤壁在生长、发育和破裂的不同时期的顺序适应。
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引用次数: 0
Three Phases of Vascular Smooth Muscle Cells in Cerebral Aneurysms: Early Hyperproliferative, Intermediate Dedifferentiated & Late Hypoproliferative 脑动脉瘤血管平滑肌细胞的三个阶段:早期高增殖、中期去分化和晚期低增殖
Pub Date : 2023-06-30 DOI: 10.47363/jnrrr/2023(5)176
Vivig Shantha Kumar
Vascular smooth muscles play a vital role in the growth and propagation of cerebral aneurysms. These highly dynamic cells, characterized by a high degree of plasticity, show structural and functional modifications in response to external environmental influences. Following sustained endothelial injury, vascular smooth muscles avail a new functional capability characterized by proinflammatory, and promatrix remodeling abilities, losing the normal contractile and synthetic ability. Switching of differentiated vascular smooth muscle cells into undifferentiated inflammatory vascular smooth muscle cells followed by eventual apoptosis decreases the production of collagen, a vital component of the structural matrix, rendering the vessel wall less responsive to cyclical hemodynamic pressure swings and more susceptible to aneurysmal dilatation and rupture. The goal of this review is to understand the structural and functional modifications that vascular smooth muscle cells undergo during the natural course of cerebral aneurysm formation with a particular focus on the contributory molecular mechanisms
血管平滑肌在脑动脉瘤的生长和传播中起着至关重要的作用。这些高度动态的细胞具有高度的可塑性,在外部环境影响下表现出结构和功能上的变化。在持续的内皮损伤后,血管平滑肌获得了新的功能,其特征是促炎和促基质重塑能力,失去了正常的收缩和合成能力。分化的血管平滑肌细胞转变为未分化的炎性血管平滑肌细胞,并最终发生凋亡,减少了胶原蛋白的产生,胶原蛋白是结构基质的重要组成部分,使血管壁对周期性血流动力学压力波动的反应减弱,更容易发生动脉瘤扩张和破裂。本综述的目的是了解血管平滑肌细胞在脑动脉瘤形成的自然过程中所经历的结构和功能改变,并特别关注其分子机制
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引用次数: 0
Cook’s FSD Dysregulation: Functional System Regulation Using A Spiritual Growth-Oriented Learning Model 2.3 Cook的FSD失调:基于精神成长导向学习模型的功能系统调节
Pub Date : 2023-05-31 DOI: 10.47363/jnrrr/2023(5)174
Tricia M. Cook, Joseph Nwoye
In accordance to the pathophysiology of dyslexia, the RAS (Reticular Activating System) and ACC (Anterior Cingulate Cortex) are two brain regions that are involved in noradrenergic signaling, which is the transmission of nerve impulses that involve the neurotransmitter noradrenaline
根据阅读障碍的病理生理学,RAS(网状激活系统)和ACC(前扣带皮层)是参与去甲肾上腺素能信号的两个大脑区域,去甲肾上腺素能信号是涉及神经递质去甲肾上腺素的神经冲动的传递
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引用次数: 0
Autism Spectrum Disorder: History, Concept and Future Perspective 自闭症谱系障碍:历史、概念和未来展望
Pub Date : 2023-04-30 DOI: 10.47363/jnrrr/2023(5)173
N. I. da Silva
The article narrates a brief history about the first possible descriptions of autism spectrum disorder (ASD) until the publication of Leo Kanner and Hans Asperger, then reports the evolution of its definition and concept, contextualizing its first inclusion in the ICD (International Statistical Classification of Diseases and Health related problems) and DMS (Diagnostic and statistical Manual of mental disorders) up to its latest versions. It discusses the clinical picture characterized by heterogeneous manifestation and associated comorbidities. This article also presents the weight of the contribution of genetic and environmental factors in the etiology of the disorder, t he diagnosis based on clinical observation and absence of biomarkers, discussions th and efficacy and limitation of pharmacological treatment and pedagogical approaches, similarly exposes a possible research strand for ASD, developed from the production of biobanks as a source of investigation of symptoms, genetic alterations, physiological dysfunctions with the objective of identifying subgroups of individuals with ASD and thus enable the targeting of individualized and more effective interventions.
本文简要叙述了自闭症谱系障碍(ASD)最早可能的描述,直到Leo Kanner和Hans Asperger的出版,然后报告了其定义和概念的演变,并将其首次列入ICD(国际疾病和健康相关问题统计分类)和DMS(精神障碍诊断和统计手册)直到其最新版本。它讨论了以异质表现和相关合并症为特征的临床表现。本文还介绍了遗传和环境因素在疾病病因学中的作用,基于临床观察和缺乏生物标志物的诊断,讨论了药物治疗和教学方法的有效性和局限性,同样揭示了ASD可能的研究方向,从生物库的生产发展为症状,遗传改变,生理功能障碍,目的是识别自闭症个体的亚群,从而能够针对个性化和更有效的干预措施。
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引用次数: 0
Correlational Analysis Between Adjustment Problems and Emotional Intelligence During COVID-19 新冠肺炎患者适应问题与情绪智力的相关性分析
Pub Date : 2023-02-28 DOI: 10.47363/jnrrr/2023(5)170
S. Verma
Life has been incredibly challenging and unfamiliar ever since the world was shocked by the coronavirus. People said that their anxiousness and anxieties about the future had increased. The current study looked at how Adjustment Problems (AP) and Emotional Intelligence (EI) related to one another during the COVID-19 period. The online survey involved 105 participants, whose ages ranged from 18 to 55 years. Brief Adjustment Scale-6 (BASE-6) and a personal data sheet were used to assess AP and EI, respectively using the Emotional Intelligence Scale (BEIS-10) created by Davies and Lane, et al. (2010) and the Brief Adjustment Scale-6 (BASE-6). Data was gathered using an online Google Form. Results showed that there was no statistically significant difference in AP according to demographic data, including gender, age group, marital status, socioeconomic status, and level of education. On the basis of demographic data (Gender, Age group, marital status, and Socio-economic position) insignificant difference in EI was discovered, whereas significant disparities were observed in levels of education. Anxious was significantly positively correlated with Appraisal of others’ emotions. Irritability, anxiety, depression and total AP was significant negatively correlated with Regulation of own emotions. Depression was significantly negatively correlated with Utilization of emotions and total EI. Regulation of own emotions and Appraisal of others’ emotions significantly contributed to the 5.2% and 4.0% of the variance thereby successfully predicting AP. EI is a learned ability. The coronavirus epidemic has put pressure on both personal and professional lives, as it does with all crises. People need to exercise extreme discipline and self-control under this situation. These scenarios need to be handled extremely effectively, but if stress and strain from a crisis combine, it would be challenging to handle the issue, particularly during current COVID-19 epidemic.
自从世界被冠状病毒震惊以来,生活变得非常具有挑战性和陌生。人们说他们对未来的焦虑和焦虑增加了。目前的研究研究了在COVID-19期间,适应问题(AP)和情绪智力(EI)是如何相互关联的。这项在线调查涉及105名参与者,年龄从18岁到55岁不等。简要调整量表-6 (BASE-6)和个人数据表分别使用Davies和Lane等人(2010)创建的情绪智力量表(BEIS-10)和简要调整量表-6 (BASE-6)来评估AP和EI。数据是通过在线谷歌表格收集的。结果显示,从性别、年龄、婚姻状况、社会经济状况、受教育程度等人口统计数据来看,AP无统计学差异。在人口统计数据(性别、年龄、婚姻状况和社会经济地位)的基础上,发现情商差异不显著,而教育水平差异显著。焦虑与他人情绪评价呈显著正相关。易怒、焦虑、抑郁、总AP与自我情绪调节呈显著负相关。抑郁与情绪利用、总情商呈显著负相关。对自身情绪的调节和对他人情绪的评价显著贡献了5.2%和4.0%的方差,从而成功地预测了AP。EI是一种习得能力。与所有危机一样,冠状病毒疫情给个人和职业生活都带来了压力。在这种情况下,人们需要极度自律和自我控制。这些情况需要非常有效地处理,但如果危机带来的压力和紧张结合在一起,处理这个问题将具有挑战性,特别是在当前COVID-19流行期间。
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引用次数: 0
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Journal of Neurology Research Reviews & Reports
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