Pub Date : 2020-04-29DOI: 10.32592/jbirjandunivmedsci.2021.28.1.103
Background and Aims: Various therapies and surgeries are applied in heart valve surgery, including interrupted and semi-continuous suture techniques. Therefore, this study aimed to compare the clinical implications of two methods of interrupted and semi-continuous suture techniques during and after mitral or aortic valve replacement surgery among patients referred to Department of Surgery, School of Medicine, Birjand University of Medical Sciences. Materials and Methods: In this study, the required information of patients was collected through the checklist based on the objectives of the study. The subjects had undergone aortic or mitral valve replacement for heart valve replacement suturing with continuous or interrupted suturing techniques. The patientschr('39') records were examined to investigate the complications, and in case that the required information was not registered, the patient or his relatives were also contacted so that the patient could be examined and referred to the hospital by the patientchr('39')s surgeon. Results: The mean age scores of patients undergoing surgery in the continuous and interrupted suture groups were obtained as 53.06±13.48 and 52.86±12.97 years, respectively. It was revealed that there was a large distribution of heart valve leakage, arrhythmia, heart attack, valve infection, involved valve type, and aortic and mitral valve size in the two groups; however, there was no significant difference (P>0.05). Conclusion: Based on the results of this study, the rate of cardiac function and complications caused by the two techniques of continuous and interrupted suturing were not significantly different from each other; therefore, these two methods were not superior to each other due to the mentioned cases.
{"title":"Comparison of Clinical Outcomes Seprate and semi continus sewing methods during and after Heart valves Surgery","authors":"","doi":"10.32592/jbirjandunivmedsci.2021.28.1.103","DOIUrl":"https://doi.org/10.32592/jbirjandunivmedsci.2021.28.1.103","url":null,"abstract":"Background and Aims: Various therapies and surgeries are applied in heart valve surgery, including interrupted and semi-continuous suture techniques. Therefore, this study aimed to compare the clinical implications of two methods of interrupted and semi-continuous suture techniques during and after mitral or aortic valve replacement surgery among patients referred to Department of Surgery, School of Medicine, Birjand University of Medical Sciences.\u0000Materials and Methods: In this study, the required information of patients was collected through the checklist based on the objectives of the study. The subjects had undergone aortic or mitral valve replacement for heart valve replacement suturing with continuous or interrupted suturing techniques. The patientschr('39') records were examined to investigate the complications, and in case that the required information was not registered, the patient or his relatives were also contacted so that the patient could be examined and referred to the hospital by the patientchr('39')s surgeon.\u0000Results: The mean age scores of patients undergoing surgery in the continuous and interrupted suture groups were obtained as 53.06±13.48 and 52.86±12.97 years, respectively. It was revealed that there was a large distribution of heart valve leakage, arrhythmia, heart attack, valve infection, involved valve type, and aortic and mitral valve size in the two groups; however, there was no significant difference (P>0.05).\u0000Conclusion: Based on the results of this study, the rate of cardiac function and complications caused by the two techniques of continuous and interrupted suturing were not significantly different from each other; therefore, these two methods were not superior to each other due to the mentioned cases.","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76001646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-29DOI: 10.32592/jbirjandunivmedsci.2021.28.1.105
Mohammad Hasan Dashti Khavidaki, Fatemeh Rassekh, A. Minaeifar
Background and Aims: The present study aimed to compare the effects of three therapeutic methods (including herbal, atorvastatin, and exercise) on liver enzymes and lipid profiles in hypercholesterolemic rats. Materials and Methods: A number of 32 male Wistar rats were randomly assigned to four groups (n=8), including hypercholesterolemia (Hc) control group, anvil extract at a dose of 100 mg/kg, (Ext), exercise (E), and atorvastatin (AT) at a dose 10 mg/kg. Endurance training, anvil extract, and atorvastatin were performed three sessions per week for 8 weeks. Thereafter, liver biochemical tests, including alkaline phosphatase (ALT), aspartate aminotransferase (AST), and lipid profiles were performed using a biochemical autoanalyzer (Ra-2000 made in USA) and the kits provided by Pars Azmun company. The data were analyzed in SPSS software using analysis of variance (ANOVA) and Tukeychr('39')s test were used for data analysis. Results: The results of statistical analysis indicated that all variables (e.g., Alanine transaminase, Triglyceride, High-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL), except for ALT, AST, and cholesterol, were significant in all groups. The results of the statistical analysis demonstrated that triglycerides and VLDL significantly reduced in the atorvastatin and exercise groups, compared to the hypercholesterolemic control group. Furthermore, HDL had a significant increase in the exercise group, compared to the atorvastatin, extract, and control groups. In addition, LDL significantly decreased in the exercise group, compared to the atorvastatin group. Conclusion: The results of the current study pointed to the similar effects of medication and exercise on the improvement of some lipid profiles. Nonetheless, exercise is advantageous over the use of medicine and herbal extracts due to the positive effects of exercise on the reduction of blood lipids and the absence of any side effects.
{"title":"Comparison of the effect of three therapies on liver enzymes and lipid profiles in hypercholesterolemic rats","authors":"Mohammad Hasan Dashti Khavidaki, Fatemeh Rassekh, A. Minaeifar","doi":"10.32592/jbirjandunivmedsci.2021.28.1.105","DOIUrl":"https://doi.org/10.32592/jbirjandunivmedsci.2021.28.1.105","url":null,"abstract":"Background and Aims: The present study aimed to compare the effects of three therapeutic methods (including herbal, atorvastatin, and exercise) on liver enzymes and lipid profiles in hypercholesterolemic rats.\u0000Materials and Methods: A number of 32 male Wistar rats were randomly assigned to four groups (n=8), including hypercholesterolemia (Hc) control group, anvil extract at a dose of 100 mg/kg, (Ext), exercise (E), and atorvastatin (AT) at a dose 10 mg/kg. Endurance training, anvil extract, and atorvastatin were performed three sessions per week for 8 weeks. Thereafter, liver biochemical tests, including alkaline phosphatase (ALT), aspartate aminotransferase (AST), and lipid profiles were performed using a biochemical autoanalyzer (Ra-2000 made in USA) and the kits provided by Pars Azmun company. The data were analyzed in SPSS software using analysis of variance (ANOVA) and Tukeychr('39')s test were used for data analysis.\u0000Results: The results of statistical analysis indicated that all variables (e.g., Alanine transaminase, Triglyceride, High-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL), except for ALT, AST, and cholesterol, were significant in all groups. The results of the statistical analysis demonstrated that triglycerides and VLDL significantly reduced in the atorvastatin and exercise groups, compared to the hypercholesterolemic control group. Furthermore, HDL had a significant increase in the exercise group, compared to the atorvastatin, extract, and control groups. In addition, LDL significantly decreased in the exercise group, compared to the atorvastatin group.\u0000Conclusion: The results of the current study pointed to the similar effects of medication and exercise on the improvement of some lipid profiles. Nonetheless, exercise is advantageous over the use of medicine and herbal extracts due to the positive effects of exercise on the reduction of blood lipids and the absence of any side effects.","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"22 6S 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76514725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-29DOI: 10.32592/jbirjandunivmedsci.2021.28.2.104
Somaye Salari Seddigh, Fateme Daneshdar, A. Tavasoli, M. Sadeghi, E. Hakimizadeh, I. Fatemi
Background and Aims: Bromelain is a substance derived from pineapple and has antioxidant, anti-inflammatory, and analgesic effects. This study aimed to investigate the effect of bromelain on the healing of tooth extraction sockets in an animal model. Materials and Methods: This experimental study was performed on 24 male rats. After anesthesia, the first maxillary molar tooth was extracted with minimal damage using a hemostat. The rats were randomly divided into two groups, namely control and bromelain. In the bromelain group, the rats were orally administered by gavage with a 500 mg dose of bromelain that was dissolved in water twice a day for 2 days, while the control group received no medications. On the 3rd and 10th days after the surgery, 6 rats were killed per group each day. Afterward, the maxillae of rats were removed and slides were prepared from their dental sockets. The slides were examined by light microscope for histopathological variables (mean of macrophages, fibroblasts, lymphocytes, neutrophils; granulation tissue extent and angiogenesis and bone cells). Results: The results showed that the angiogenesis and granulation tissue extent increased significantly in the bromelain group, compared to the control group, on the 3rd day (P<0.05). Also, bromelain administration significantly increase the the number of fibroblasts (P<0.01), granulation tissue extent (P<0.05) and angiogenesis (P<0.05) in 3rd day of the experiment in comparison with the 10th day. Conclusion: The results of the present study showed that bromelain accelerates the process of wound healing after tooth extraction.
{"title":"Microscopic examination of the effect of bromelain on the healing of tooth extraction sockets in an animal model","authors":"Somaye Salari Seddigh, Fateme Daneshdar, A. Tavasoli, M. Sadeghi, E. Hakimizadeh, I. Fatemi","doi":"10.32592/jbirjandunivmedsci.2021.28.2.104","DOIUrl":"https://doi.org/10.32592/jbirjandunivmedsci.2021.28.2.104","url":null,"abstract":"Background and Aims: Bromelain is a substance derived from pineapple and has antioxidant, anti-inflammatory, and analgesic effects. This study aimed to investigate the effect of bromelain on the healing of tooth extraction sockets in an animal model.\u0000Materials and Methods: This experimental study was performed on 24 male rats. After anesthesia, the first maxillary molar tooth was extracted with minimal damage using a hemostat. The rats were randomly divided into two groups, namely control and bromelain. In the bromelain group, the rats were orally administered by gavage with a 500 mg dose of bromelain that was dissolved in water twice a day for 2 days, while the control group received no medications. On the 3rd and 10th days after the surgery, 6 rats were killed per group each day. Afterward, the maxillae of rats were removed and slides were prepared from their dental sockets. The slides were examined by light microscope for histopathological variables (mean of macrophages, fibroblasts, lymphocytes, neutrophils; granulation tissue extent and angiogenesis and bone cells).\u0000Results: The results showed that the angiogenesis and granulation tissue extent increased significantly in the bromelain group, compared to the control group, on the 3rd day (P<0.05). Also, bromelain administration significantly increase the the number of fibroblasts (P<0.01), granulation tissue extent (P<0.05) and angiogenesis (P<0.05) in 3rd day of the experiment in comparison with the 10th day.\u0000Conclusion: The results of the present study showed that bromelain accelerates the process of wound healing after tooth extraction.","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86977930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-29DOI: 10.32592/JBIRJANDUNIVMEDSCI.2021.28.1.104
سمیه کسرائی, سیدرضا عطارزاده حسینی, مهرداد فتحی
Background and Aims: Klotho protein is a substance effective in increasing life expectancy. Moreover, it prevents muscle atrophy, osteoporosis, and cardiovascular disease. Therefore, the present aimed to assess changes in the expression of klotho protein and insulin-like growth factor 1 (IGF-1) genes in the muscles of aged Wistar rats after eight weeks of resistance training. Materials and Methods: The present experimental study was connected on 16 Wistar male rats, aged 20 months, which were assigned to two groups of resistance training group and control. Resistance training was performed three sessions a week over eight weeks. After dissecting the rats, the soleus and flexor hallucis longus muscles of the rats were extracted to measure the expression of klotho protein and (IGF-1) genes using the real-time polymerase chain reaction technique. Results: After the resistance training program, Klotho protein in the fast-twitch muscle tissue of the trained rats did not show a significant difference, compared to that in the control group. Furthermore, IGF-1 in the fast-twitch and slow-twitch muscles of the training group did not display a marked difference, compared to that in the control group. Conclusion: As evidenced by the obtained results, the values of klotho protein and IGF-1 did not improve after a period of resistance training. It can be argued that resistance training should be conducted in longer periods and with different intensities, which should be scrutinized in future research.
{"title":"Effect of eight weeks of resistance training on the expression of klotho protein and insulin-like growth factor 1 genes in slow twitch and fast twitch skeletal muscles of aged Wistar rats","authors":"سمیه کسرائی, سیدرضا عطارزاده حسینی, مهرداد فتحی","doi":"10.32592/JBIRJANDUNIVMEDSCI.2021.28.1.104","DOIUrl":"https://doi.org/10.32592/JBIRJANDUNIVMEDSCI.2021.28.1.104","url":null,"abstract":"Background and Aims: Klotho protein is a substance effective in increasing life expectancy. Moreover, it prevents muscle atrophy, osteoporosis, and cardiovascular disease. Therefore, the present aimed to assess changes in the expression of klotho protein and insulin-like growth factor 1 (IGF-1) genes in the muscles of aged Wistar rats after eight weeks of resistance training.\u0000Materials and Methods: The present experimental study was connected on 16 Wistar male rats, aged 20 months, which were assigned to two groups of resistance training group and control. Resistance training was performed three sessions a week over eight weeks. After dissecting the rats, the soleus and flexor hallucis longus muscles of the rats were extracted to measure the expression of klotho protein and (IGF-1) genes using the real-time polymerase chain reaction technique.\u0000Results: After the resistance training program, Klotho protein in the fast-twitch muscle tissue of the trained rats did not show a significant difference, compared to that in the control group. Furthermore, IGF-1 in the fast-twitch and slow-twitch muscles of the training group did not display a marked difference, compared to that in the control group.\u0000Conclusion: As evidenced by the obtained results, the values of klotho protein and IGF-1 did not improve after a period of resistance training. It can be argued that resistance training should be conducted in longer periods and with different intensities, which should be scrutinized in future research.","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69704957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-24DOI: 10.32592/jbirjandunivmedsci.2020.27.4.101
Mahraz Moradi, S. Shakerian, M. Nikbakht
Background and Aim: The use of doxorubicin (Dox) in chemotherapy has irreversible effects on liver tissue. Therefore, the role of exercise activities and the use of antioxidants consumption on the mechanism of apoptosis induced by (Dox are not yet fully understood. Therefore, the aim of the present study was to investigate the effect of High Intensity Interval Training (HIIT) and crocin consumption on liver tissue apoptosis in male rats under chronic Dox induction. Materials and Methods: In this experimental study, 40 male Wistar rats (mean weight 200±20 g)and age range of 8 weeks divided into five groups including; 1: healthy control groups, 2: Dox (2 mg/kg in 7 doses), 3: Dox+crocin (10 mg/kg), 4: Dox+HIIT, and 5: Dox+HIIT+crocin. The training groups ran for 8 weeks, 5 days a week, at 2-minute intervals and with an intensity of 80 to 90% of the maximum speed. 48 hours after the last training session, liver biopsy were performed to assess the fibrosis and expression of Bax and Bcl-2 genes by (Real time-PCR) method. The results of statistical analysis were analyzed using by one-way (ANOVA), at p≤0.05. Results: Dox significantly increased Bax expression compared to Bax/Bcl-2 and also decreased Bcl-2 expression in liver tissue of the patient groups (p=0.001). In contrast, crocin and the combination of exercise and crocin decreased Bax expression compared to Bax/Bcl-2 and increased Bcl-2 expression in experimental groups compared to Dox group (p=0.001). Conclusion: It seems the high intensity interval training with consumption of crocin has significant effect on the decrease of apoptosis in liver tissue in male rats subjected to chronic doxorubicin injection.
{"title":"The effect of eight weeks of high intensity interval training and crocin consumption on the apoptotic genes expression in the liver tissue of male rats under chronic doxorubicin induction","authors":"Mahraz Moradi, S. Shakerian, M. Nikbakht","doi":"10.32592/jbirjandunivmedsci.2020.27.4.101","DOIUrl":"https://doi.org/10.32592/jbirjandunivmedsci.2020.27.4.101","url":null,"abstract":"Background and Aim: The use of doxorubicin (Dox) in chemotherapy has irreversible effects on liver tissue. Therefore, the role of exercise activities and the use of antioxidants consumption on the mechanism of apoptosis induced by (Dox are not yet fully understood. Therefore, the aim of the present study was to investigate the effect of High Intensity Interval Training (HIIT) and crocin consumption on liver tissue apoptosis in male rats under chronic Dox induction.\u0000Materials and Methods: In this experimental study, 40 male Wistar rats (mean weight 200±20 g)and age range of 8 weeks divided into five groups including; 1: healthy control groups, 2: Dox (2 mg/kg in 7 doses), 3: Dox+crocin (10 mg/kg), 4: Dox+HIIT, and 5: Dox+HIIT+crocin.\u0000The training groups ran for 8 weeks, 5 days a week, at 2-minute intervals and with an intensity of 80 to 90% of the maximum speed. 48 hours after the last training session, liver biopsy were performed to assess the fibrosis and expression of Bax and Bcl-2 genes by (Real time-PCR) method. The results of statistical analysis were analyzed using by one-way (ANOVA), at p≤0.05.\u0000Results: Dox significantly increased Bax expression compared to Bax/Bcl-2 and also decreased Bcl-2 expression in liver tissue of the patient groups (p=0.001). In contrast, crocin and the combination of exercise and crocin decreased Bax expression compared to Bax/Bcl-2 and increased Bcl-2 expression in experimental groups compared to Dox group (p=0.001).\u0000Conclusion: It seems the high intensity interval training with consumption of crocin has significant effect on the decrease of apoptosis in liver tissue in male rats subjected to chronic doxorubicin injection.","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79496994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-18DOI: 10.32592/JBIRJANDUNIVMEDSCI.2021.28.1.107
Ebrahim Shafaie, A. T. Kareshk, M. Namaei, Mehran Rostami
Helicobacter pylori (HP) is the most common human pathogen. Due to differences in HP prevalence in different geographical areas, this study was conducted to investigate the seroprevalence of HP in patients with gastrointestinal disorders referring to Imam Reza Hospital in Birjand, Iran, in 2018. After blood sampling of 2,550 patients, the anti-HP antibody titer was measured by a commercial kit. The positive serum response of HP in this study was shown in 1,045 individuals (41%). The results of the present study showed that there was no significant relation between serum positive reaction and gender. In addition, the immunoglobulin G (IgG) antibody with 83% was the most abundant antibody in individuals with positive seropositive reaction. Epidemiological studies, especially serum IgG, can highly help with the detection of HP infection, particularly in individuals with clinical symptoms (P<0.05).
{"title":"Seroepidemiology of Helicobacter pylori in patients with gastrointestinal disorders referring to Imam Reza Hospital in Birjand, Iran: Short Communication","authors":"Ebrahim Shafaie, A. T. Kareshk, M. Namaei, Mehran Rostami","doi":"10.32592/JBIRJANDUNIVMEDSCI.2021.28.1.107","DOIUrl":"https://doi.org/10.32592/JBIRJANDUNIVMEDSCI.2021.28.1.107","url":null,"abstract":"Helicobacter pylori (HP) is the most common human pathogen. Due to differences in HP prevalence in different geographical areas, this study was conducted to investigate the seroprevalence of HP in patients with gastrointestinal disorders referring to Imam Reza Hospital in Birjand, Iran, in 2018. After blood sampling of 2,550 patients, the anti-HP antibody titer was measured by a commercial kit. The positive serum response of HP in this study was shown in 1,045 individuals (41%). The results of the present study showed that there was no significant relation between serum positive reaction and gender. In addition, the immunoglobulin G (IgG) antibody with 83% was the most abundant antibody in individuals with positive seropositive reaction. Epidemiological studies, especially serum IgG, can highly help with the detection of HP infection, particularly in individuals with clinical symptoms (P<0.05).","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72533089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-11DOI: 10.32592/jbirjandunivmedsci.2020.27.4.108
Z. Saremi, T. Fakharian
Celiac disease is one of the most common autoimmune diseases with a prevalence of 0.5 to 1% of the total population. Diagnosis has increased in recent years, but many cases of the disease still seem to be diagnosed late. Although the rheumatic manifestations of celiac disease are not uncommon, they are often overlooked. The patient was a 30-year-old woman with swelling of the joints of the fingers and knees who referred to the rheumatology clinic of vali-asr Hospital in Birjand. For the past 2 years, despite treatment with corticosteroids and anti-rheumatic drugs that modulate the immune system, migratory inflammatory arthritis was still present. Serologic tests for celiac disease were performed for the patient and she underwent endoscopy and duodenal biopsy. The diagnosis of celiac disease was confirmed for the patient. With a gluten-free diet, joint symptoms improved significantly. Rheumatologic manifestations of celiac disease can be the primary symptoms of the disease, with the gluten-free diet prescribed for these patients to a large extent relieve symptoms.
{"title":"Undiagnosed celiac disease in a patient with polyarthritis: Case Report","authors":"Z. Saremi, T. Fakharian","doi":"10.32592/jbirjandunivmedsci.2020.27.4.108","DOIUrl":"https://doi.org/10.32592/jbirjandunivmedsci.2020.27.4.108","url":null,"abstract":"Celiac disease is one of the most common autoimmune diseases with a prevalence of 0.5 to 1% of the total population. Diagnosis has increased in recent years, but many cases of the disease still seem to be diagnosed late. Although the rheumatic manifestations of celiac disease are not uncommon, they are often overlooked.\u0000The patient was a 30-year-old woman with swelling of the joints of the fingers and knees who referred to the rheumatology clinic of vali-asr Hospital in Birjand. For the past 2 years, despite treatment with corticosteroids and anti-rheumatic drugs that modulate the immune system, migratory inflammatory arthritis was still present. Serologic tests for celiac disease were performed for the patient and she underwent endoscopy and duodenal biopsy. The diagnosis of celiac disease was confirmed for the patient. With a gluten-free diet, joint symptoms improved significantly.\u0000Rheumatologic manifestations of celiac disease can be the primary symptoms of the disease, with the gluten-free diet prescribed for these patients to a large extent relieve symptoms.","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81599342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-30DOI: 10.32592/jbirjandunivmedsci.2020.27.1.109
{"title":"knowledge, attitude and performance regarding oral and","authors":"","doi":"10.32592/jbirjandunivmedsci.2020.27.1.109","DOIUrl":"https://doi.org/10.32592/jbirjandunivmedsci.2020.27.1.109","url":null,"abstract":"","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91108754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"موانع کیفیت آموزش بالینی از دیدگاه دانشجویان پزشکی دانشگاه علوم پزشکی بیرجند در سال تحصیلی 98-97","authors":"فاطمه سلمانی, بتول اقبالی, محمود گنجی فرد, یحیی محمدی, سیاوش کافیان عطاری, تهمینه توکلی","doi":"10.32592/JBIRJANDUNIVMEDSCI.2020.27.1.108","DOIUrl":"https://doi.org/10.32592/JBIRJANDUNIVMEDSCI.2020.27.1.108","url":null,"abstract":"","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"27 1","pages":"100-109"},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69704914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.32592/jbirjandunivmedsci.2020.27.1.100
Sadegh Vahabi-Amlashi, Faezeh Taghavi, A. Taheri
Old World cutaneous leishmaniasis (OWCL) is a relatively common parasitic infection that is among endemic diseases in many regions worldwide, particularly in Iran. Leishmania major and Leishmania tropica species with over 500,000 and 400,000 annual cases are considered the two main causes of OWCL, respectively. Diagnosis and treatment of cutaneous leishmaniasis (CL) can be difficult due to alterations in clinical manifestations and resistance to treatment.There is currently no vaccine available for (CL). Its systemic treatment also has serious and severe side effects.The uncomplicated cases of (CL) in a person with healthy immunity can be managed alone by topical treatment as an effective and less complicated treatment and may not require other systemic therapies.This study aims to describe topical treatment methods for OWCL.
{"title":"Local therapy in cutaneous leishmaniasis: a review study","authors":"Sadegh Vahabi-Amlashi, Faezeh Taghavi, A. Taheri","doi":"10.32592/jbirjandunivmedsci.2020.27.1.100","DOIUrl":"https://doi.org/10.32592/jbirjandunivmedsci.2020.27.1.100","url":null,"abstract":"Old World cutaneous leishmaniasis (OWCL) is a relatively common parasitic infection that is among endemic diseases in many regions worldwide, particularly in Iran. Leishmania major and Leishmania tropica species with over 500,000 and 400,000 annual cases are considered the two main causes of OWCL, respectively. Diagnosis and treatment of cutaneous leishmaniasis (CL) can be difficult due to alterations in clinical manifestations and resistance to treatment.There is currently no vaccine available for (CL). Its systemic treatment also has serious and severe side effects.The uncomplicated cases of (CL) in a person with healthy immunity can be managed alone by topical treatment as an effective and less complicated treatment and may not require other systemic therapies.This study aims to describe topical treatment methods for OWCL.","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"27 1","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47403704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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