Pub Date : 2020-03-10DOI: 10.32592/jbirjandunimedsci.2020.27.2.109
F. Abedi, M. Namaei, Z. Hamidi, M. Soltani, Zahra Kiani
Hand hygiene is the most effective, simplest, and least expensive way to prevent the spread of hospital infections. Hand hygiene needs an ingredient that shows effectiveness in reducing microbial load in a way; alcohol-based hand rubs have more effective, fast and long-lasting disinfection than other antiseptics. The aim of this study was to prepare and optimization of an alcoholbased hand rub solution recommended by world health organization to reduce expenses in sanction situations and also enhance the satisfaction and tolerability of the product. Key Words: Alcohol-Based Hand Rub; Disinfection; Optimization; Production; World Health Organization
{"title":"Production and optimization of hand disinfection solution\u0000based on the World Health Organization formulation: a short\u0000article","authors":"F. Abedi, M. Namaei, Z. Hamidi, M. Soltani, Zahra Kiani","doi":"10.32592/jbirjandunimedsci.2020.27.2.109","DOIUrl":"https://doi.org/10.32592/jbirjandunimedsci.2020.27.2.109","url":null,"abstract":"Hand hygiene is the most effective, simplest, and least expensive way to prevent the spread of hospital infections. Hand hygiene\u0000needs an ingredient that shows effectiveness in reducing microbial load in a way; alcohol-based hand rubs have more effective, fast\u0000and long-lasting disinfection than other antiseptics. The aim of this study was to prepare and optimization of an alcoholbased\u0000hand rub solution recommended by world health organization to reduce expenses in sanction situations and also\u0000enhance the satisfaction and tolerability of the product.\u0000Key Words: Alcohol-Based Hand Rub; Disinfection; Optimization; Production; World Health Organization","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75154288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.32592/jbirjandunivmedsci.2020.27.1.103
Asma Soltanalizadeh, C. Ahmadizadeh
Background and Aim: Researches have shown that promoter methylation of the CADM1 gene is one of the main mechanisms is to silence its expression in cancer cells. The objective of this study was to determine the methylation pattern of the CADM1 gene promoter and to quantify the human papillomavirus. Materials and Methods: In this research, 75 tumor tissues and 75 tumor marginal tissue samples taken from patients with definitive diagnosis of cervical cancer were examined. After extraction of DNA and ensuring the quality and quantity of DNA extracted by spectrophotometry and the agarose gel electrophoresis method, the methylation pattern of the CADM1was performed by the HRM method. Determining the methylation pattern of the CADM1 gene, without considering the type of involved variants was performed by using the Eva Green method and comparing the high-resolution melting point and HPV quantities were determined after isolation from the block. Results: Methylation of CADM1 gene in cervical tumor cells increased significantly (P< 0.0001) in comparison with the tumor margin before and after radiotherapy. But the change in the level of methylation of tumor cells before and after radiotherapy was not significant. This means that radiotherapy does not affect the level of methylation of the CADM1 gene. Moreover, the level of methylation of CADM1 gene in patients with HPV titer higher than 500 ml / IU was significantly more than that of patients with HPV titer lower than 500 ml / IU. Conclusion: Use of DNA methylated of the cancer cells as a prognosis for cervical cancer in HPV positive women it’s appropriate, also the CADM1 gene can be used as a marker of cervical cancer.
{"title":"Investigation of simultaneous of CADM1 gene methylation pattern and HPV virus quantification as a diagnostic biomarker in Cervical Cancer","authors":"Asma Soltanalizadeh, C. Ahmadizadeh","doi":"10.32592/jbirjandunivmedsci.2020.27.1.103","DOIUrl":"https://doi.org/10.32592/jbirjandunivmedsci.2020.27.1.103","url":null,"abstract":"Background and Aim: Researches have shown that promoter methylation of the CADM1 gene is one of the main mechanisms is to silence its expression in cancer cells. The objective of this study was to determine the methylation pattern of the CADM1 gene promoter and to quantify the human papillomavirus. Materials and Methods: In this research, 75 tumor tissues and 75 tumor marginal tissue samples taken from patients with definitive diagnosis of cervical cancer were examined. After extraction of DNA and ensuring the quality and quantity of DNA extracted by spectrophotometry and the agarose gel electrophoresis method, the methylation pattern of the CADM1was performed by the HRM method. Determining the methylation pattern of the CADM1 gene, without considering the type of involved variants was performed by using the Eva Green method and comparing the high-resolution melting point and HPV quantities were determined after isolation from the block. Results: Methylation of CADM1 gene in cervical tumor cells increased significantly (P< 0.0001) in comparison with the tumor margin before and after radiotherapy. But the change in the level of methylation of tumor cells before and after radiotherapy was not significant. This means that radiotherapy does not affect the level of methylation of the CADM1 gene. Moreover, the level of methylation of CADM1 gene in patients with HPV titer higher than 500 ml / IU was significantly more than that of patients with HPV titer lower than 500 ml / IU. Conclusion: Use of DNA methylated of the cancer cells as a prognosis for cervical cancer in HPV positive women it’s appropriate, also the CADM1 gene can be used as a marker of cervical cancer.","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"27 1","pages":"44-55"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48856804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.32592/jbirjandunivmedsci.2020.27.1.106
maryam parvizfar, M. Ghanbarzadeh, S. Shakeriyan, H. Tavakol
Background and Aim: Exercises to reduce respiratory symptoms of asthma and Vitamin D by regulating the immune system can play a significant role in the health of asthmatic patients. The purpose of the present study was to investigate the effect of short-term consumption of vitamin D supplements following a session of increasing activity on respiratory parameters and tolerance to activity of women with mild asthma. Materials and Methods: This study was quasi-experimental based on the pre-test and post-test pattern that following the announcement of the call, 30 asthmatic women volunteered in Ahwaz was performed. Ballk test for cardiopulmonary patients was used for increasing aerobic exercise. Supplementation with vitamin D tablets at a dose of 1000 units daily was performed for six weeks. For evaluation of pulmonary Vital Capacity (VC) and Maximum Voluntary Ventilation (MVV) indices, the Spirometer device was used. To determine normality of the data was used Shapiro-Wilk's test and data analysis by using paired t-test. Results: The results showed that after the intervention, there was a significant difference in VC and MVV levels and tolerance to activity in the pre-test, supplementation and exercise stages (P ≤ 0.05(. Conclusion: Taking vitamin D supplementation with aerobic exercise can improve respiratory function in asthmatic patients and increase tolerance to activity.
{"title":"The effect of short-term consumption of vitamin D Supplements following a session of increasing activity on respiratory parameters and toleratance to activity of women with mild asthma","authors":"maryam parvizfar, M. Ghanbarzadeh, S. Shakeriyan, H. Tavakol","doi":"10.32592/jbirjandunivmedsci.2020.27.1.106","DOIUrl":"https://doi.org/10.32592/jbirjandunivmedsci.2020.27.1.106","url":null,"abstract":"Background and Aim: Exercises to reduce respiratory symptoms of asthma and Vitamin D by regulating the immune system can play a significant role in the health of asthmatic patients. The purpose of the present study was to investigate the effect of short-term consumption of vitamin D supplements following a session of increasing activity on respiratory parameters and tolerance to activity of women with mild asthma. Materials and Methods: This study was quasi-experimental based on the pre-test and post-test pattern that following the announcement of the call, 30 asthmatic women volunteered in Ahwaz was performed. Ballk test for cardiopulmonary patients was used for increasing aerobic exercise. Supplementation with vitamin D tablets at a dose of 1000 units daily was performed for six weeks. For evaluation of pulmonary Vital Capacity (VC) and Maximum Voluntary Ventilation (MVV) indices, the Spirometer device was used. To determine normality of the data was used Shapiro-Wilk's test and data analysis by using paired t-test. Results: The results showed that after the intervention, there was a significant difference in VC and MVV levels and tolerance to activity in the pre-test, supplementation and exercise stages (P ≤ 0.05(. Conclusion: Taking vitamin D supplementation with aerobic exercise can improve respiratory function in asthmatic patients and increase tolerance to activity.","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"27 1","pages":"80-89"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48238059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.32592/JBIRJANDUNIVMEDSCI.2020.27.1.101
O. Yaghoubi, H. Ahanchian, A. Rezaeean, S. Seyedi
Background and Aim: Asthma is the first cause of absenteeism and the third cause of hospitalization for children under the age of 15. It is causes psychological and emotional problems, decrease self-esteem. Lack of control of it can lead to frequent hospitalization of affected children. Perhaps providing information in an attractive way about their illness will improve their self-efficacy. Therefore, the present study aims to evaluate the effect of animation and pamphlet-based discharge program on the self-efficacy of children with asthma was designed. Materials and Methods: This randomized clinical trial was conducted in Akbar Hospital in 2018, with participation of 90 patients that randomly allocated three groups of 30 animation, pamphlet and control. In the animation group, given educational CD and pamphlet group given pamphlet for twice a week about 2 months, and in the control group, information was provided in the routine section. Before and after intervention, self efficacy of children was measured. Data were analyzed by SPSS software version 16 and one way ANOVA, Kolmogorov–Smirnov, Kruskal Wallis, paired t-test, Chi-square tests and Tukey post hoc. Results: After the intervention, the self-efficacy score of the animation group was significantly higher than the pamphlet and control group (p <0.001). In comparison, intra-group self-efficacy was significantly increased in all three groups after two months compared to baseline (p <0.001). Conclusion: The discharge program based on animation promotes self-efficacy in children with asthma and recommends paying more attention to nursing care.
背景和目的：哮喘是 15 岁以下儿童缺勤的第一大原因，也是住院的第三大原因。哮喘会导致心理和情绪问题，降低自尊心。对哮喘缺乏控制会导致患儿频繁住院。也许以有吸引力的方式提供有关其疾病的信息会提高他们的自我效能感。因此，本研究旨在评估基于动画和小册子的出院计划对哮喘患儿自我效能感的影响。材料与方法：本随机临床试验于2018年在阿克巴医院进行，共有90名患者参与，随机分配动画、小册子和对照三组，每组30人。动画组发放教育光盘，小册子组发放小册子，每周两次，为期约 2 个月，对照组在常规科室提供信息。在干预前后，对儿童的自我效能感进行了测量。数据采用 SPSS 软件 16 版进行分析，并进行了单向方差分析、Kolmogorov-Smirnov 检验、Kruskal Wallis 检验、配对 t 检验、Chi-square 检验和 Tukey post hoc 检验。结果干预后，动画组的自我效能感得分明显高于小册子组和对照组（P <0.001）。与基线相比，两个月后三组的组内自我效能感均有显著提高（P <0.001）。结论基于动画的出院计划可提高哮喘患儿的自我效能感，并建议他们更加重视护理工作。
{"title":"Investigating the effect of animation and pamphlet-based discharge program on the self-efficacy of children with asthma","authors":"O. Yaghoubi, H. Ahanchian, A. Rezaeean, S. Seyedi","doi":"10.32592/JBIRJANDUNIVMEDSCI.2020.27.1.101","DOIUrl":"https://doi.org/10.32592/JBIRJANDUNIVMEDSCI.2020.27.1.101","url":null,"abstract":"Background and Aim: Asthma is the first cause of absenteeism and the third cause of hospitalization for children under the age of 15. It is causes psychological and emotional problems, decrease self-esteem. Lack of control of it can lead to frequent hospitalization of affected children. Perhaps providing information in an attractive way about their illness will improve their self-efficacy. Therefore, the present study aims to evaluate the effect of animation and pamphlet-based discharge program on the self-efficacy of children with asthma was designed. Materials and Methods: This randomized clinical trial was conducted in Akbar Hospital in 2018, with participation of 90 patients that randomly allocated three groups of 30 animation, pamphlet and control. In the animation group, given educational CD and pamphlet group given pamphlet for twice a week about 2 months, and in the control group, information was provided in the routine section. Before and after intervention, self efficacy of children was measured. Data were analyzed by SPSS software version 16 and one way ANOVA, Kolmogorov–Smirnov, Kruskal Wallis, paired t-test, Chi-square tests and Tukey post hoc. Results: After the intervention, the self-efficacy score of the animation group was significantly higher than the pamphlet and control group (p <0.001). In comparison, intra-group self-efficacy was significantly increased in all three groups after two months compared to baseline (p <0.001). Conclusion: The discharge program based on animation promotes self-efficacy in children with asthma and recommends paying more attention to nursing care.","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":" 46","pages":"22-32"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141223582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-10DOI: 10.32592/jbirjandunivmedsci.2020.27.1.107
B. Mansouri, M. Rezaei, sayedusef javadmusavi, A. Amirabadi
{"title":"Evaluate the serum level of magnesium, manganese, and selenium in patients with hypothyroidism, hyperthyroidism and thyroid cancer in South Khorasan in 2018","authors":"B. Mansouri, M. Rezaei, sayedusef javadmusavi, A. Amirabadi","doi":"10.32592/jbirjandunivmedsci.2020.27.1.107","DOIUrl":"https://doi.org/10.32592/jbirjandunivmedsci.2020.27.1.107","url":null,"abstract":"","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"27 1","pages":"90-99"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44684511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-05DOI: 10.32592/jbirjandunimedsci.2020.27.2.101
Samane Haji Mohammad Khani, Z. Abedian, A. Azhari, M. Shakeri, M. Talebi
Background and Aim: Prederm delivery, and the consequences are include premature newborn, hospitalization in the NICU ward, psychological damage to mother and heart family performing low-cost, practical interventions can play an important role in promoting maternal health by to reduce psychological trauma. Therefore, the present study was performed to determine the impact of physical-mental exercises on depression after prederm delivery. Materials and Methods: In this clinical trial, 100 women with prederm delivery 28-36 weeks, it was performed in public hospitals in Mashhad in 2019. Sampling was performed by random blocking method and the subjects were selected by available method and were divided into two control groups (n=50) and intervention (n=50). The intervention group performed stretching exercises as well as meditation by the researcher on the third day after delivery with a frequency of two sessions per week for up to 8 sessions, and the control group received the usual care. Beck's depression questionnaire was completed for both groups in the first 24 hours after delivery and at the end of the study. Statistical analysis of the data was performed by independent t-test, Mann-Whitney and Wilkaxon. Results: The mean score of depression in the intervention and control groups at the end of the study was statistically significant (p≤0.001). The mean score of depression in the intervention group was significant at the beginning and the end of the study (P<0.001). Conclusion: Stretching exercises with a focus on the body after delivery can reduce the rate of depression in mothers with prederm delivery. Key Words: Meditation; Postpartum Depression; prederm delivery; Stretching Exercise
{"title":"Investigating the impact of physical-mental exercises on\u0000depression after prederm delivery: a clinical trial","authors":"Samane Haji Mohammad Khani, Z. Abedian, A. Azhari, M. Shakeri, M. Talebi","doi":"10.32592/jbirjandunimedsci.2020.27.2.101","DOIUrl":"https://doi.org/10.32592/jbirjandunimedsci.2020.27.2.101","url":null,"abstract":"Background and Aim: Prederm delivery, and the consequences are include premature newborn, hospitalization in the NICU ward,\u0000psychological damage to mother and heart family performing low-cost, practical interventions can play an important role in\u0000promoting maternal health by to reduce psychological trauma. Therefore, the present study was performed to determine the impact of\u0000physical-mental exercises on depression after prederm delivery.\u0000Materials and Methods: In this clinical trial, 100 women with prederm delivery 28-36 weeks, it was performed in public hospitals\u0000in Mashhad in 2019. Sampling was performed by random blocking method and the subjects were selected by available method and\u0000were divided into two control groups (n=50) and intervention (n=50). The intervention group performed stretching exercises as well\u0000as meditation by the researcher on the third day after delivery with a frequency of two sessions per week for up to 8 sessions, and the\u0000control group received the usual care. Beck's depression questionnaire was completed for both groups in the first 24 hours after\u0000delivery and at the end of the study. Statistical analysis of the data was performed by independent t-test, Mann-Whitney and\u0000Wilkaxon.\u0000Results: The mean score of depression in the intervention and control groups at the end of the study was statistically significant\u0000(p≤0.001). The mean score of depression in the intervention group was significant at the beginning and the end of the study\u0000(P<0.001).\u0000Conclusion: Stretching exercises with a focus on the body after delivery can reduce the rate of depression in mothers with prederm\u0000delivery.\u0000Key Words: Meditation; Postpartum Depression; prederm delivery; Stretching Exercise","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81718482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-02DOI: 10.32592/jbirjandunivmedsci.2020.27.3.102
S. Hosseini, Fereshteh Eidy, M. Khoshbakht, Saman Khantaraj, M. Firooz
Background and Aim: Thrombophlebitis is considered as a major cause of peripheral intravenous catheters (PICs) failure. The flushing technique in the laboratory has been effective in clearing the catheter duct, but its effectiveness in the clinical setting is unknown, therefore, the aim of this study was to determine the effect of pulsatile flushing on phlebitis, type, and duration of PICs patency in patients. Materials and Methods: In this double-blind clinical trial, 71 patients admitted to the inpatient and surgical wards of Imam Khomeini Esfarayen Hospital were randomly assigned to the intervention and control groups after sampling by available methods. In the intervention group, the flushing technique was performed by injecting 1 ml of the normal saline solution for one second, then interrupting less than one second and repeating the injection and interrupting until the end of 5 ml of the solution. The Consequences of this study were phlebitis, duration, and type of PICs patency, which were evaluated every 12 hours by using Jackson's phlebitis instrument and direct observation of the catheter. Results: The incidence of phlebitis in the intervention group was lower than the control group (P<0.001). In addition, two groups had a statistically significant difference in the type of PICs (P<0.001). The median duration of PICs patency in the intervention group was significantly higher than the control group (P<0.001). Conclusion: Pulsatile flushing is an effective technique to increase longevity of PICs and recommended as a practical method in clinical setting.
{"title":"The effects of pulsatile flushing on phlebitis and peripheral intravenous\u0000catheters patency","authors":"S. Hosseini, Fereshteh Eidy, M. Khoshbakht, Saman Khantaraj, M. Firooz","doi":"10.32592/jbirjandunivmedsci.2020.27.3.102","DOIUrl":"https://doi.org/10.32592/jbirjandunivmedsci.2020.27.3.102","url":null,"abstract":"Background and Aim: Thrombophlebitis is considered as a major cause of peripheral intravenous catheters\u0000(PICs) failure. The flushing technique in the laboratory has been effective in clearing the catheter duct, but\u0000its effectiveness in the clinical setting is unknown, therefore, the aim of this study was to determine the effect\u0000of pulsatile flushing on phlebitis, type, and duration of PICs patency in patients.\u0000Materials and Methods: In this double-blind clinical trial, 71 patients admitted to the inpatient and surgical\u0000wards of Imam Khomeini Esfarayen Hospital were randomly assigned to the intervention and control groups\u0000after sampling by available methods. In the intervention group, the flushing technique was performed by\u0000injecting 1 ml of the normal saline solution for one second, then interrupting less than one second and\u0000repeating the injection and interrupting until the end of 5 ml of the solution. The Consequences of this study\u0000were phlebitis, duration, and type of PICs patency, which were evaluated every 12 hours by using Jackson's\u0000phlebitis instrument and direct observation of the catheter.\u0000Results: The incidence of phlebitis in the intervention group was lower than the control group (P<0.001). In\u0000addition, two groups had a statistically significant difference in the type of PICs (P<0.001). The median\u0000duration of PICs patency in the intervention group was significantly higher than the control group (P<0.001).\u0000Conclusion: Pulsatile flushing is an effective technique to increase longevity of PICs and recommended as a\u0000practical method in clinical setting.","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82402515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-29DOI: 10.32592/jbirjandunimedsci.2020.27.2.100
M. Aghasizadeh, M. Mobarhan, T. Kazemi, A. Avan, E. M. Moghaddam
High-density lipoprotein (HDL) is a set of particles with heterogeneous structures that have different functions due to various compounds including surface charge, size, lipid, and protein compounds. Several prospective epidemiological studies have demonstrated that there is a clear inverse relationship between serum HDL concentration and risk of coronary heart disease, despite this relationship, clinical evidence has only challenged the usefulness of higher levels of HDL-C in predicting the risk of cardiovascular diseases (CVD) and have proven that the structure of HDL is altered and loosed function. Therefore, extensive research is needed to identify new agents and biomarkers to improve HDL function and reduce the risk of cardiovascular disease. Given that the most important function of HDL is to transfer excess cholesterol from peripheral tissues and macrophage cells through a receptor called ABCA1 and direct it to the liver, plays an important role in protecting the formation of atherosclerotic plaque. This molecule can provide a strong protective effect against oxidative damage caused by free radicals with intermittent inhibition of the production of pro-inflammatory oxidized lipids in the intima layer of arteries. There is an inverse relationship between the ability to efflux cholesterol and the prevalence of CVD. The ability to remove cholesterol from macrophages by HDL, it is a crucial criterion for determining HDL performance, and it has a strong inverse relationship with carotid intima-media thickness and coronary artery stenosis in angiography independent of HDL level. Key Words: Atherosclerosis; Cardiovascular Disease; High Density Lipoprotein; Lipoprotein
{"title":"The role of level and function of High Density Lipoprotein (HDL) in Cardiovascular Diseases","authors":"M. Aghasizadeh, M. Mobarhan, T. Kazemi, A. Avan, E. M. Moghaddam","doi":"10.32592/jbirjandunimedsci.2020.27.2.100","DOIUrl":"https://doi.org/10.32592/jbirjandunimedsci.2020.27.2.100","url":null,"abstract":"High-density lipoprotein (HDL) is a set of particles with heterogeneous structures that have different functions due to various compounds including surface charge, size, lipid, and protein compounds. Several prospective epidemiological studies have demonstrated that there is a clear inverse relationship between serum HDL concentration and risk of coronary heart disease, despite this relationship, clinical evidence has only challenged the usefulness of higher levels of HDL-C in predicting the risk of cardiovascular diseases (CVD) and have proven that the structure of HDL is altered and loosed function. Therefore, extensive research is needed to identify new agents and biomarkers to improve HDL function and reduce the risk of cardiovascular disease. Given that the most important function of HDL is to transfer excess cholesterol from peripheral tissues and macrophage cells through a receptor called ABCA1 and direct it to the liver, plays an important role in protecting the formation of atherosclerotic plaque. This molecule can provide a strong protective effect against oxidative damage caused by free radicals with intermittent inhibition of the production of pro-inflammatory oxidized lipids in the intima layer of arteries. There is an inverse relationship between the ability to efflux cholesterol and the prevalence of CVD.\u0000The ability to remove cholesterol from macrophages by HDL, it is a crucial criterion for determining HDL performance, and it has a strong inverse relationship with carotid intima-media thickness and coronary artery stenosis in angiography independent of HDL level.\u0000Key Words: Atherosclerosis; Cardiovascular Disease; High Density Lipoprotein; Lipoprotein","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90744890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-22DOI: 10.32592/jbirjandunimedsci.2020.27.2.104
M. Maslakpak, Shahin Alipour, N. Aghakhani, Hamidreza Khalkhali
Background and Aim: The family can play an important role in adapting patients with diabetes to lifestyle changes, so that the family, as the most essential pillar of society, is responsible for the proper care of the patient with diabetes; Therefore, the present study was conducted to determine the effect of family-centered care on the adherence to treatment of patients with type 2 diabetes. Materials and Methods: In this quasi-experimental study, 80 patients with type 2 diabetes and one member of their family were selected by convenience sampling method and randomly assigned to two of intervention and control groups. Adherence to treatment was assessed using a researcher-made questionnaire and laboratory values before and 3 months after the intervention. Data were analyzed using the Kolmogorov-Smirnov, Independent t-test, paired t-test, and Chi-square test. Results: After the implementation of the family-centered care program, increased mean scores for patient adherence to treatment in the intervention group compared to the control group, this increase was statistically significant (p=0.0001). The results showed a decrease in the mean score of fasting blood glucose, random blood glucose and glycosylated hemoglobin in the intervention group compared to the control group. This decrease was statistically significant (P = 0.0001). Conclusion: Family-centered care can increase adherence to treatment, and decrease fasting blood glucose, random blood glucose and hemoglobin glycosylated levels. Therefore, it is recommended that family pay more attention to diabetic members. Key Words: Adherence to Treatment; Blood glucose; Family-Centered Nursing; Type 2 Diabetes Mellitus
{"title":"The effect of family-centered care on adherence to\u0000treatment in patients with type 2 diabetes","authors":"M. Maslakpak, Shahin Alipour, N. Aghakhani, Hamidreza Khalkhali","doi":"10.32592/jbirjandunimedsci.2020.27.2.104","DOIUrl":"https://doi.org/10.32592/jbirjandunimedsci.2020.27.2.104","url":null,"abstract":"Background and Aim: The family can play an important role in adapting patients with diabetes to lifestyle changes, so that the\u0000family, as the most essential pillar of society, is responsible for the proper care of the patient with diabetes; Therefore, the present\u0000study was conducted to determine the effect of family-centered care on the adherence to treatment of patients with type 2 diabetes.\u0000Materials and Methods: In this quasi-experimental study, 80 patients with type 2 diabetes and one member of their family were\u0000selected by convenience sampling method and randomly assigned to two of intervention and control groups. Adherence to treatment\u0000was assessed using a researcher-made questionnaire and laboratory values before and 3 months after the intervention. Data were\u0000analyzed using the Kolmogorov-Smirnov, Independent t-test, paired t-test, and Chi-square test.\u0000Results: After the implementation of the family-centered care program, increased mean scores for patient adherence to treatment in\u0000the intervention group compared to the control group, this increase was statistically significant (p=0.0001). The results showed a\u0000decrease in the mean score of fasting blood glucose, random blood glucose and glycosylated hemoglobin in the intervention group\u0000compared to the control group. This decrease was statistically significant (P = 0.0001).\u0000Conclusion: Family-centered care can increase adherence to treatment, and decrease fasting blood glucose, random blood glucose\u0000and hemoglobin glycosylated levels. Therefore, it is recommended that family pay more attention to diabetic members.\u0000Key Words: Adherence to Treatment; Blood glucose; Family-Centered Nursing; Type 2 Diabetes Mellitus","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"47 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91365913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-15DOI: 10.32592/jbirjandunimedsci.2020.27.2.102
R. Javanshir, M. Hemmati
Background and Aim: Coenzyme Q10 is an antioxidant it is now used in diseases associated with oxidative stress. Given the importance of oxidative stress in the complications of diabetes, this study aimed to investigate the effect of CoQ10 supplementation on the status of oxidative stress and insulin resistance was performed in diabetic rats. Materials and Methods: 18 Sprague-Dawley male rats were randomly divided into 3 groups (n=6). The control group received the physiological serum, the diabetic group (STZ: 55 mg/kg) received sesame oil, and the supplement group, which was diabetic, received Q10 intraperitoneal (i.p) at a dose of 2 mg/kg per day for 10 days. At the end of the tenth day, a venous blood sample was collected. Plasma levels of glucose, insulin, vitamin D, total antioxidant capacity, malondialdehyde (MDA), and protein thiol groups were measured using the corresponding colorimetric methods. Results: The results showed that treatment of diabetic rats with CoQ10 supplementation significantly reduced fasting blood sugar (FBS) and MDA levels and significantly increased serum insulin and vitamin D levels compared to diabetic rats (P<0.05).The average weight, thiol groups, insulin resistance, and total antioxidant capacity in the treated diabetic rats with CoQ10 supplementation varied compared with the diabetic control group but were not significant (p>0.05). Conclusion: Consumption of CoQ10 supplementation can reduce the oxidative stress caused by diabetes through its antioxidant effects. Key Words: Antioxidant; Coenzyme Q10; Diabetes Mellitus; Vitamin D
{"title":"The effect of coenzyme Q10 supplementation on oxidative stress status and insulin resistance in diabetic rats","authors":"R. Javanshir, M. Hemmati","doi":"10.32592/jbirjandunimedsci.2020.27.2.102","DOIUrl":"https://doi.org/10.32592/jbirjandunimedsci.2020.27.2.102","url":null,"abstract":"Background and Aim: Coenzyme Q10 is an antioxidant it is now used in diseases associated with oxidative stress. Given the importance of oxidative stress in the complications of diabetes, this study aimed to investigate the effect of CoQ10 supplementation on the status of oxidative stress and insulin resistance was performed in diabetic rats.\u0000Materials and Methods: 18 Sprague-Dawley male rats were randomly divided into 3 groups (n=6). The control group received the physiological serum, the diabetic group (STZ: 55 mg/kg) received sesame oil, and the supplement group, which was diabetic, received Q10 intraperitoneal (i.p) at a dose of 2 mg/kg per day for 10 days. At the end of the tenth day, a venous blood sample was collected. Plasma levels of glucose, insulin, vitamin D, total antioxidant capacity, malondialdehyde (MDA), and protein thiol groups were measured using the corresponding colorimetric methods.\u0000Results: The results showed that treatment of diabetic rats with CoQ10 supplementation significantly reduced fasting blood sugar (FBS) and MDA levels and significantly increased serum insulin and vitamin D levels compared to diabetic rats (P<0.05).The average weight, thiol groups, insulin resistance, and total antioxidant capacity in the treated diabetic rats with CoQ10 supplementation varied compared with the diabetic control group but were not significant (p>0.05).\u0000Conclusion: Consumption of CoQ10 supplementation can reduce the oxidative stress caused by diabetes through its antioxidant effects.\u0000Key Words: Antioxidant; Coenzyme Q10; Diabetes Mellitus; Vitamin D","PeriodicalId":31015,"journal":{"name":"Journal of Birjand University of Medical Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84150021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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