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The Prognostic Value of Systemic Immune-Inflammation Index in Non-Small Cell Lung Cancer with ALK Rearrangement 全身免疫炎症指数对ALK重排非小细胞肺癌的预后价值
Pub Date : 1900-01-01 DOI: 10.14744/ejmi.2020.41303
B. Burak, S. Yucel
DOI: 10.14744/ejmi.2020.41303 EJMI 2020;4(2):134–139
DOI: 10.14744/ejmi.2020.41303 EJMI 2020;4(2):134-139
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引用次数: 1
Clinical Outcomes of Kaposi’s Sarcoma Treated with Systemic Chemotherapy 全身化疗治疗卡波西肉瘤的临床疗效
Pub Date : 1900-01-01 DOI: 10.14744/ejmi.2020.96330
Abdilkerim Oyman
DOI: 10.14744/ejmi.2020.96330 EJMI 2021;5(1):12–15
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引用次数: 1
Characteristics of Presentation and metabolic Risk Factors in Relation to Extent of Involvement in Infants with Nephrolithiasis 婴儿肾结石的表现特点及与受累程度相关的代谢危险因素
Pub Date : 1900-01-01 DOI: 10.14744/ejmi.2019.87741
Kenan Yılmaz, Mustafa Erman Dorterler
DOI: 10.14744/ejmi.2019.87741 EJMI 2020;4(1):78–85
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引用次数: 3
The Effects of Isolated Oligohydramnios in Term Pregnancies on Labor, Delivery Mode, and Neonatal Outcomes 足月妊娠孤立性羊水过少对产程、分娩方式和新生儿结局的影响
Pub Date : 1900-01-01 DOI: 10.14744/ejmi.2019.12005
N. Yenigul, O. Aşıcıoğlu
DOI: 10.14744/ejmi.2019.12005 EJMI 2019;3(1):59–64
DOI: 10.14744/ejmi.2019.12005 EJMI 2019;3(1):59-64
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引用次数: 2
Predictive Value of Lymphocyte-Related Blood Parameters of before Ado-Trastuzumab Emtansin Treatment in Breast Cancer ado -曲妥珠单抗Emtansin治疗乳腺癌前淋巴细胞相关血液参数的预测价值
Pub Date : 1900-01-01 DOI: 10.14744/ejmi.2022.10130
G. Bulut
Objective: Ado-Trastuzumab Emtansine ( TDM1) has been used in the treatment of HER2 metastatic breast cancer after FDA approval as an antibody-drug conjugate. Some markers may be predictive for clinician in the management of this TDM1 therapy. There is a need for simple and cost-effective markers to show the treatment response. The primary aim of this study is to establish a correlation between progression free survival and pre-treatment hematological inflammatory parameters [absolute lymphocyte count (ALC), neutrophil-to-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR)] in advance breast cancer. Methods: Forty-one female patients with metastatic HER-2 positive breast cancer who received TDM-1 between 2016 and 2021 were evaluated retrospectively. NLR and PLR were calculated with the values of neutrophils, lymphocytes, and trombocytes in complete blood count at the time of diagnosis. The cut off values of NLR and PLR were determined using receiver operating characteristic (ROC) curve analysis. Overall survival (OS) and progression free survival (PFS) associated with prior treatment NLR, PLR, ALC were performed by Kaplan-Meier method. Results: Median age was 49.5 years years (26-76).Patients divided into 2 groups according to NLR cut-off and TLR cutoff values as NLR/TLR high and low groups. The cut-off values of NLR and TLR were 144.0, and 2.74, respectively. ALC divided into 2 groups. There was no significant difference in OS between NLR ,PLR,ALC (high/low) groups. (p=0.04, 0.15, 0.53 respectively). There was only significant difference in PFS (high/low) groups.(p=0.81, 0.99, 0.96 respectively). Conclusions: The predictive value of pre-treatment only NLR on the therapeutic potential in patients with metastatic breast cancer treated with TDM1.
目的:经FDA批准,ado -曲妥珠单抗Emtansine (TDM1)作为抗体-药物偶联物已被用于治疗HER2转移性乳腺癌。在TDM1治疗的管理中,一些标记物可能对临床医生具有预测性。需要一种简单且具有成本效益的标记物来显示治疗反应。本研究的主要目的是建立无进展生存期与治疗前血液学炎症参数[绝对淋巴细胞计数(ALC)、中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)]之间的相关性。方法:回顾性分析2016 - 2021年间41例接受TDM-1治疗的转移性HER-2阳性乳腺癌患者。NLR和PLR以诊断时全血细胞计数中中性粒细胞、淋巴细胞和血小板的值计算。采用受试者工作特征(ROC)曲线分析确定NLR和PLR的截止值。总生存期(OS)和无进展生存期(PFS)与既往治疗NLR、PLR、ALC相关,采用Kaplan-Meier法进行。结果:中位年龄为49.5岁(26-76岁)。根据NLR截止值和TLR截止值将患者分为NLR/TLR高、低两组。NLR和TLR的临界值分别为144.0和2.74。ALC分为2组。NLR组、PLR组、ALC组的OS(高/低)差异无统计学意义。(p分别=0.04,0.15,0.53)。PFS高/低组间差异有统计学意义(p分别为0.81、0.99、0.96)。结论:治疗前仅NLR对TDM1治疗转移性乳腺癌患者治疗潜力的预测价值。
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引用次数: 0
Tuberculosis and Malignancy Coexistence with Cavitary Lesion in the Lung Radiologically 肺内结核与恶性肿瘤共存伴空腔病变的影像学分析
Pub Date : 1900-01-01 DOI: 10.14744/EJMI.2019.29294
Gaye Celikkan
DOI: 10.14744/ejmi.2019.29294 EJMI 2019;3(3):245-247
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引用次数: 0
Incidental Enchondromas Of The Lower Extremity Long Bones And Atypical Chondroid Tumors Differentiation Based On Hounsfield Units 基于Hounsfield单位的下肢长骨偶发内生瘤与非典型软骨样肿瘤的鉴别
Pub Date : 1900-01-01 DOI: 10.14744/ejmi.2022.47497
O. Balta
Objectives: To determine the prevalence of enchondroma (EC) in adults, which was detected as an incidental finding in the lower extremity long bones on magnetic resonance imaging (MRI) and to detect imaging differences between EC and atypical chondroid tumor (ACT). Methods: A retrospective review of lower extremity MRI scans was performed in patients over 18 years of age. The location, size, and appearance of ECs and ACTs were established. The patients who were diagnosed with definitive EC and ACT after undergoing a biopsy were evaluated whether they had computed tomography (CT) examinations. Sagittal, coronal and axial reconstructions were performed in the patients with CT. Overall, minimum and maximum Hounsfield Units measurements were conducted in all 3 planes using region-of-interest (ROI) circles. Results: A total of 20,864 MR scans were reviewed. EC was detected in 2.2% and ACT in 0.08% of all MRIs including the lower extremity long bones. EC was observed to be most in the MR images taken for the knee (2.209%). EC was detected to be 1.6% in the proximal femur, 1.9% in the femur diaphysis, 1.8% in the distal femur, and 0.4% in the proximal tibia. Conclusion: The present study showed that tumors may be significant for ACT if their length is more than 4.5 cm, their width is greater than 2 cm, and they are growing more than 6 mm at follow-up. It was determined that the lower the CT attenuation measurements (Hounsfield Units), the higher the probability of having ACT. Abstract Cite This Article: Balta O, Altinayak H, Zengin EC, Eren MB, Demir O, Aytekin K. Incidental Enchondromas of the Lower Ex- tremity Long Bones and Atypical Chondroid Tumors Differentiation Based on Hounsfield Units. EJMI 2022;6(2):245–258.
目的:确定成人内软骨瘤(EC)的患病率,该疾病是在磁共振成像(MRI)上偶然发现的下肢长骨,并检测EC与非典型软骨样肿瘤(ACT)的影像学差异。方法:对18岁以上患者的下肢MRI扫描进行回顾性分析。确定ECs和ACTs的位置、大小和外观。活检后确诊为EC和ACT的患者评估是否进行了计算机断层扫描(CT)检查。CT对患者进行矢状面、冠状面和轴状面重建。总体而言,使用感兴趣区域(ROI)圆在所有3个平面上进行最小和最大Hounsfield单位测量。结果:共回顾了20,864张MR扫描。包括下肢长骨在内的所有mri中,EC检出率为2.2%,ACT检出率为0.08%。在膝关节的MR图像中,EC最多(2.209%)。EC在股骨近端为1.6%,股骨骨干为1.9%,股骨远端为1.8%,胫骨近端为0.4%。结论:本研究表明,如果肿瘤长度大于4.5 cm,宽度大于2 cm,随访时肿瘤生长大于6mm,则ACT可能具有显著意义。CT衰减测量值(霍斯菲尔德单位)越低,发生ACT的概率越高。Balta O, Altinayak H, Zengin EC, even MB, Demir O, Aytekin K.基于Hounsfield单位的下肢长骨偶发内生软骨瘤与非典型软骨样肿瘤的鉴别。EJMI 2022; 6(2): 245 - 258。
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引用次数: 0
Addiction in Adolescents During COVID-19 Pandemic: A Systematic Review COVID-19大流行期间青少年成瘾:一项系统综述
Pub Date : 1900-01-01 DOI: 10.14744/ejmi.2021.28744
M. Gul
spend their time at home, physical activity, social life and social interaction have been severely restricted. Fear of illness, losing a close person, limitation of interaction with peers, changes in eating habits and sleep patterns, etc. affected children and adolescents as well as adults and uncertainty of the period have caused an increase in psychological and social problems in this age group. Especially the school closures, maintaining education with online distance education both have decreased the efficiency in education and caused children and adolescents to spend most of their time in the internet. Internet has not been used only for school and lessons, also using for entertainment have caused prolonged exposure to screens. As well as behavioral addictions, substance use in order to cope with difficulties has become a worthy subject to investigate in this period. It is predicted that the ongoing pandemic process will accelerate the studies about addictions in adolescents. In this review, we aimed to take attention to studies on addiction in adolescents during the COVID-19 pandemic. Abstract Cite This Article: Gul MK, Demirci E. Addiction in Adolescents During COVID-19 Pandemic: A Systematic Review. EJMI 2022;6(3):267–272.
他们在家里度过的时间,身体活动、社交生活和社会交往都受到了严重限制。对疾病的恐惧、失去亲密的人、与同伴交往的限制、饮食习惯和睡眠模式的改变等影响到儿童和青少年以及成年人,以及时期的不确定性导致了这一年龄组心理和社会问题的增加。特别是学校关闭,以在线远程教育维持教育,既降低了教育效率,又导致儿童和青少年将大部分时间花在互联网上。互联网不仅用于上学和上课,也用于娱乐,导致长时间暴露在屏幕前。与行为成瘾一样,为了应对困难而使用物质也成为这一时期值得研究的课题。据预测,目前的流行病进程将加速对青少年成瘾的研究。在这篇综述中,我们旨在关注COVID-19大流行期间青少年成瘾的研究。Gul MK, Demirci E.。COVID-19大流行期间青少年成瘾:一项系统综述。EJMI 2022; 6(3): 267 - 272。
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引用次数: 1
Clinicopathological Features of Gastroenteropancreatic Neuroendocrine Tumors: A Retrospective Evaluation of 149 Cases 149例胃肠胰神经内分泌肿瘤的临床病理特征分析
Pub Date : 1900-01-01 DOI: 10.14744/ejmi.2022.21011
T. Koseci
Objectives: Gastroenteropancreatic neuroendocrine tumors (GEP-NET) are heterogeneous tumor groups, and they are rarely seen. Our study aims to analyze the clinicopathologic, demographic, and survival features of patients with GEP-NET. Methods: The data of 149 patients was collected retrospectively. Clinicopathologic, demographic, and survival features of patients with GEP-NET were investigated. Survival analysis was performed by using the Kaplan–Meier method and compared with the log-rank test. Univariate and multivariate analyses were performed to determine independent prognostic predictors of overall survival (OS). Results: Of 149 patients with GEP-NET, 65 patients (43.6%) were female and 84 patients (56.4%) were male. The most common, primary site of GEP-NET was stomach (40.3%). It was followed by pancreas (17.4%), small bowel/appendix (16.8%), colorectal (14%), and unknown primary (11.5%), respectively. The 3- and 5-year OS rate for the entire cohort were 69% and 60%, respectively. Median OS was not calculated, but the mean OS was 66.2 months. The factors significantly affecting the OS rate were age, grade, presence of metastasis at diagnosis, tumor diameter, and Ki-67 proliferation index in the univariate analysis. However, age was only meaningful in the multivariate analysis. Conclusion: Patients with GEP-NET under 50 age who have smaller tumor diameter, lower tumor grade, Ki-67 proliferation index, and absence of metastasis at the diagnosis have more prolonged survival. Abstract
目的:胃肠胰神经内分泌肿瘤(GEP-NET)是一种罕见的异质性肿瘤。我们的研究旨在分析GEP-NET患者的临床病理、人口统计学和生存特征。方法:回顾性分析149例患者的临床资料。研究了GEP-NET患者的临床病理、人口统计学和生存特征。采用Kaplan-Meier法进行生存分析,并与log-rank检验进行比较。进行单因素和多因素分析以确定总生存期(OS)的独立预后预测因子。结果:149例GEP-NET患者中,女性65例(43.6%),男性84例(56.4%)。GEP-NET最常见的原发部位是胃(40.3%)。其次是胰腺(17.4%)、小肠/阑尾(16.8%)、结肠(14%)和未知原发(11.5%)。整个队列的3年和5年生存率分别为69%和60%。中位生存期未计算,但平均生存期为66.2个月。单因素分析中,年龄、肿瘤分级、诊断时有无转移、肿瘤直径、Ki-67增殖指数是影响肿瘤总生存率的主要因素。然而,年龄仅在多变量分析中有意义。结论:年龄小于50岁的GEP-NET患者诊断时肿瘤直径小、肿瘤分级低、Ki-67增殖指数低、无转移者生存期更长。摘要
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引用次数: 1
The Radiotherapy Adherence of Patients in Time of COVID-19 Pandemic COVID-19大流行时期患者放疗依从性分析
Pub Date : 1900-01-01 DOI: 10.14744/ejmi.2022.51946
F. Tugrul
as space, equipment, and personnel. The present study tried to assess how the fear of hospitals and the pandemic measures affected the radiotherapy course of patients. Methods: The records of patients receiving active cancer therapy in the department of radiation oncology were retrospectively analyzed. Treatment delays before and after March 11, 2020, were recorded. Results: None of the 80 patients (0%) failed to complete radiotherapy before March 11, 2020, while 5 of 55 patients (9.1%) had radiotherapy cessation after the first COVID-19 case and the following restrictions in Turkey (p<0.01). There was no difference in treatment type between the groups; no difference between palliative and curative subgroups before and after the pandemic (p=0.22). There was no difference in overall survival between pre- and post-COVID-19 periods (p=0.35). Conclusion: However, some patients may not receive adequate diagnostic procedures during this period. The regulations to prevent the spread of the COVID-19 may harm specific patient populations such as radiotherapy patients. The non-specific rules and declarations confuse the patients and prevent them from accessing the treatment needed. In the case of pandemic regulations, government decisions may include special considerations for oncological patients. Abstract Cite This Article: Tugrul F, Beypinar I. The Radiotherapy Adherence of Patients in Time of COVID-19 Pandemic. EJMI 2022;6(4):512–516.
如空间、设备和人员。本研究试图评估对医院和流行病措施的恐惧如何影响患者的放射治疗过程。方法:回顾性分析放射肿瘤科接受肿瘤积极治疗的患者资料。记录了2020年3月11日前后的治疗延误情况。结果:80例患者(0%)在2020年3月11日前均未完成放疗,而土耳其55例患者中有5例(9.1%)在第一例COVID-19病例及以下限制后停止放疗(p<0.01)。两组间治疗方式无差异;大流行前后姑息治疗亚组和治疗亚组之间无差异(p=0.22)。covid -19前后的总生存率无差异(p=0.35)。结论:然而,一些患者在此期间可能没有得到充分的诊断程序。防止COVID-19传播的规定可能会损害特定患者群体,如放疗患者。不具体的规则和声明使患者感到困惑,并阻止他们获得所需的治疗。就大流行法规而言,政府的决定可能包括对肿瘤患者的特殊考虑。[摘要]引用本文:Tugrul F, Beypinar I. COVID-19大流行时期患者放疗依从性的研究。EJMI 2022; 6(4): 512 - 516。
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引用次数: 0
期刊
Eurasian Journal of Medical Investigation
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