Pub Date : 1900-01-01DOI: 10.14744/ejmi.2022.39430
O. Aydın
Objectives: This study aimed to determine syphilis coinfection prevalence in people living with HIV (PLHIV) and risk factors for coinfection. Methods: This single-center retrospective cohort study screened PLHIV who were monitored in our center between March 2000 and February 2020 via the hospital’s database and analyzed them by grouping as TPHA-positive and TPHA-negative. TPHA positivity was considered as indicative of Treponema pallidum exposure. Results: The study included 474 PLHIV of whom median age (IQR) was 37 (30-47), and 429 (90.5%) were male. Of the male participants, 206 (47.9%) were MSM. The syphilis coinfection rate was 30.2% (143/474). Among the participants with syphilis coinfection, 80 (16.9%) were found to be coinfected with syphilis at the time of their HIV diagnosis, while 63 (13.3%) got infected with syphilis at a median (IQR) time of 60 (36-84) months into their HIV follow-up and treatment. Syphilis coinfection was related to being male (p<0.001), MSM (p=0.008) and single (p=0.007). Regular condom use was inversely related to syphilis coinfection (p=0.002). Conclusion: HIV and syphilis have similar transmission routes, and HIV and syphilis coinfection is common among men, MSM and people who do not use condoms. PLHIV should be tested regularly for syphilis and informed about risky sexual behaviors and protection methods. Abstract
{"title":"Seroprevalence and risk factors of syphilis coinfection in people living with HIV","authors":"O. Aydın","doi":"10.14744/ejmi.2022.39430","DOIUrl":"https://doi.org/10.14744/ejmi.2022.39430","url":null,"abstract":"Objectives: This study aimed to determine syphilis coinfection prevalence in people living with HIV (PLHIV) and risk factors for coinfection. Methods: This single-center retrospective cohort study screened PLHIV who were monitored in our center between March 2000 and February 2020 via the hospital’s database and analyzed them by grouping as TPHA-positive and TPHA-negative. TPHA positivity was considered as indicative of Treponema pallidum exposure. Results: The study included 474 PLHIV of whom median age (IQR) was 37 (30-47), and 429 (90.5%) were male. Of the male participants, 206 (47.9%) were MSM. The syphilis coinfection rate was 30.2% (143/474). Among the participants with syphilis coinfection, 80 (16.9%) were found to be coinfected with syphilis at the time of their HIV diagnosis, while 63 (13.3%) got infected with syphilis at a median (IQR) time of 60 (36-84) months into their HIV follow-up and treatment. Syphilis coinfection was related to being male (p<0.001), MSM (p=0.008) and single (p=0.007). Regular condom use was inversely related to syphilis coinfection (p=0.002). Conclusion: HIV and syphilis have similar transmission routes, and HIV and syphilis coinfection is common among men, MSM and people who do not use condoms. PLHIV should be tested regularly for syphilis and informed about risky sexual behaviors and protection methods. Abstract","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125903876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Value of FDG PET/CT in Predicting Pathologic Complete Response After Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer","authors":"M. Ayhan","doi":"10.14744/ejmi.2022.43076","DOIUrl":"https://doi.org/10.14744/ejmi.2022.43076","url":null,"abstract":"DOI: 10.14744/ejmi.2022.43076 EJMI 2022;6(2):165–175","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126153023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2022.87902
S. Ebinç
sta-Objectives: In locally advanced rectal cancer, the standard treatment approach consists of post-neoadjuvant surgery and adjuvant chemotherapy. In this study, we aimed to evaluate the clinicopathological characteristics of patients receiving neoadjuvant therapy for a diagnosis of rectal cancer and to compare the survival outcomes of patients who underwent surgery and patients who refused the surgical approach after neoadjuvant therapy, regardless of response status. Methods: Our study included patients who presented to our clinic and underwent neoadjuvant therapy for locally ad- vanced or oligometastatic rectal carcinoma between 2011 and 2021. Patients who did not complete neoadjuvant therapy or progressed on treatment were excluded. Patient data were retrospectively reviewed using the hospital records system. Results: Our study analyzed data from a total of 123 patients, consisting of 98 (79.7%) patients in the surgery arm and 25 (20.3%) patients in the refusal arm. In our study, 65 (52.8%) patients were female and 58 (47.2%) patients were male. Median age at diagnosis was 53 years (20-86). Most of the patients (75.6%) had stage-III disease. Regarding response to neoadjuvant therapy; complete response was obtained in 16.3% (n=20), partial response was obtained in 71.5% (n=88), stable disease was obtained in 12.2% (n=15) of the patients. After neoadjuvant therapy, 20.3% of the patients had refused surgery and started follow-up. Of the 98 (79.7%) operated patients, 77 (26.6%) had been treated with a low anterior resection and 21 (17.1%) with an abdominoperineal resection. During follow-up, 29.3% (n=36) of the patients showed recurrence or progression. While progression-free survival could not be reached for operated patients, patients refusing surgery had a median recurrence free survival of 32 months (6.3-57.6) (Log-rank p=0.003). Median overall sur- vival was 144 months (46.3-241.6) in operated patients as opposed to 41 (23.0-58.9) months in those refusing surgery (Log-rank p<0.001). Operated patients and patients refusing surgery had three-year survival rates of 64.9% vs 40% (p=0.023) and five-year survival rates of 45.4% vs 16% (p=0.007), respectively. Conclusion: We determined that, in rectal cancer, both the overall survival and progression/recurrence-free survival outcomes of patients refusing surgery were poorer than those in the surgery arm, regardless of response status.
{"title":"Investigation of the Clinicopathological Characteristics and Survival Outcomes of Patients Refusing Surgery Post-Neoadjuvant Therapy in Rectal Cancer","authors":"S. Ebinç","doi":"10.14744/ejmi.2022.87902","DOIUrl":"https://doi.org/10.14744/ejmi.2022.87902","url":null,"abstract":"sta-Objectives: In locally advanced rectal cancer, the standard treatment approach consists of post-neoadjuvant surgery and adjuvant chemotherapy. In this study, we aimed to evaluate the clinicopathological characteristics of patients receiving neoadjuvant therapy for a diagnosis of rectal cancer and to compare the survival outcomes of patients who underwent surgery and patients who refused the surgical approach after neoadjuvant therapy, regardless of response status. Methods: Our study included patients who presented to our clinic and underwent neoadjuvant therapy for locally ad- vanced or oligometastatic rectal carcinoma between 2011 and 2021. Patients who did not complete neoadjuvant therapy or progressed on treatment were excluded. Patient data were retrospectively reviewed using the hospital records system. Results: Our study analyzed data from a total of 123 patients, consisting of 98 (79.7%) patients in the surgery arm and 25 (20.3%) patients in the refusal arm. In our study, 65 (52.8%) patients were female and 58 (47.2%) patients were male. Median age at diagnosis was 53 years (20-86). Most of the patients (75.6%) had stage-III disease. Regarding response to neoadjuvant therapy; complete response was obtained in 16.3% (n=20), partial response was obtained in 71.5% (n=88), stable disease was obtained in 12.2% (n=15) of the patients. After neoadjuvant therapy, 20.3% of the patients had refused surgery and started follow-up. Of the 98 (79.7%) operated patients, 77 (26.6%) had been treated with a low anterior resection and 21 (17.1%) with an abdominoperineal resection. During follow-up, 29.3% (n=36) of the patients showed recurrence or progression. While progression-free survival could not be reached for operated patients, patients refusing surgery had a median recurrence free survival of 32 months (6.3-57.6) (Log-rank p=0.003). Median overall sur- vival was 144 months (46.3-241.6) in operated patients as opposed to 41 (23.0-58.9) months in those refusing surgery (Log-rank p<0.001). Operated patients and patients refusing surgery had three-year survival rates of 64.9% vs 40% (p=0.023) and five-year survival rates of 45.4% vs 16% (p=0.007), respectively. Conclusion: We determined that, in rectal cancer, both the overall survival and progression/recurrence-free survival outcomes of patients refusing surgery were poorer than those in the surgery arm, regardless of response status.","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123469252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2022.22190
E. Karaman
Objectives: The main treatment for gastric cancer is surgery. The high recurrence and metastasis rates indicate the necessity of neoadjuvant/adjuvant treatments. Our aim was to evaluate the effects of adjuvant therapy on disease-free survival (DFS) and prognostic factors with gastric cancer patients. Methods: Gastric cancer patients who were operated between 2015-2021 were evaluated retrospectively. Clinical, pathological, surgical and therapeutic features of patients were examined. Prognostic factors, Hemoglobin Albumin Lymphocyte, Platelet Score (HALP) and metastatic lymph node ratio (MLNR) of patients were examined. 1-5 year survival rate were calculated. Results: Adjuvant chemotherapy was applied to fifty-nine patients and adjuvant chemoradiotherapy was applied to sixty-eight patients. There was no difference in demographic and clinical characteristics between patient groups who received chemotherapy and chemoradiotherapy. DFS was 34 and 52 months with chemotherapy and chemoradiotherapy patients respectively (p=0.161). High MLNR levels of patients was poor prognostic factor. HALP score did not affect prognosis. 5-years overall survival rate was better in chemoradiotherapy group, but the difference was not statistically significant (41.2% vs 50.9%, p=0.216). Conclusion: There was no difference in survival between patients who received adjuvant chemotherapy and chemoradiotherapy. MLNR of patients may be considered as a prognostic marker for gastric cancer patients with high nodal involvement.
目的:胃癌的主要治疗方法是手术。高复发和转移率表明新辅助/辅助治疗的必要性。我们的目的是评估辅助治疗对胃癌患者无病生存(DFS)和预后因素的影响。方法:对2015-2021年间行胃癌手术的患者进行回顾性分析。检查患者的临床、病理、手术及治疗特点。检测患者预后因素、血红蛋白白蛋白淋巴细胞、血小板评分(HALP)及转移性淋巴结比(MLNR)。计算1 ~ 5年生存率。结果:辅助化疗59例，辅助放化疗68例。接受化疗和放化疗的患者组在人口学和临床特征上没有差异。化疗组和放化疗组的DFS分别为34个月和52个月(p=0.161)。MLNR水平高是患者预后不良的因素。HALP评分不影响预后。放化疗组5年总生存率优于放化疗组，但差异无统计学意义(41.2% vs 50.9%， p=0.216)。结论:接受辅助化疗与放化疗的患者生存率无显著差异。患者的MLNR可作为胃癌高淋巴结累及患者的预后指标。
{"title":"Effect of Adjuvant Chemotherapy/Chemoradiotherapy on Disease-Free Survival in Gastric Cancer","authors":"E. Karaman","doi":"10.14744/ejmi.2022.22190","DOIUrl":"https://doi.org/10.14744/ejmi.2022.22190","url":null,"abstract":"Objectives: The main treatment for gastric cancer is surgery. The high recurrence and metastasis rates indicate the necessity of neoadjuvant/adjuvant treatments. Our aim was to evaluate the effects of adjuvant therapy on disease-free survival (DFS) and prognostic factors with gastric cancer patients. Methods: Gastric cancer patients who were operated between 2015-2021 were evaluated retrospectively. Clinical, pathological, surgical and therapeutic features of patients were examined. Prognostic factors, Hemoglobin Albumin Lymphocyte, Platelet Score (HALP) and metastatic lymph node ratio (MLNR) of patients were examined. 1-5 year survival rate were calculated. Results: Adjuvant chemotherapy was applied to fifty-nine patients and adjuvant chemoradiotherapy was applied to sixty-eight patients. There was no difference in demographic and clinical characteristics between patient groups who received chemotherapy and chemoradiotherapy. DFS was 34 and 52 months with chemotherapy and chemoradiotherapy patients respectively (p=0.161). High MLNR levels of patients was poor prognostic factor. HALP score did not affect prognosis. 5-years overall survival rate was better in chemoradiotherapy group, but the difference was not statistically significant (41.2% vs 50.9%, p=0.216). Conclusion: There was no difference in survival between patients who received adjuvant chemotherapy and chemoradiotherapy. MLNR of patients may be considered as a prognostic marker for gastric cancer patients with high nodal involvement.","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"03 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123564831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2022.11975
zehra gunay yagci
Objectives: In this study, we aimed to compare the healthcare workers (frontline) and other health care workers in terms of depression, anxiety, stress symptoms, obsessive-compulsive symptoms, sleep quality and quality of life. Methods: Among the doctors, nurses, assistant health personnel and medical secretaries working in Bilecik Training and Research Hospital and involved in the follow-up and treatment of COVID 19 patients. Those who accepted the study included Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Pitsburg Sleep Quality Index (PSQI), DSM 5 Posttraumatic Stress Symptoms Symptom Checklist (PCL-5), Maudsley Obsessive-Compulsive Symptom Inventory (MOCI) and World Health Organization Quality of Life Scale, Short Form (WHOQOL-BREF-TR) was given. Results: A total of 53 people were included in the study, 24 of which were in the frontline and 29 in the secondline.The number of days they worked with patients who were suspected or infected with COVID 19 and the number of those who needed mental support was significantly higher than the others. The BAI and MOCI scale scores of the frontline group were significantly higher, and the WHOQOL-BREF-TR scores were lower. Conclusion: The risk of developing psychopathology increases in all healthcare professionals, especially frontline healthcare professionals, during the pandemic period, so mental support should be provided. Abstract Article: Yagci ZG, Gol Ozcan G, Yagci T, Ceylan D. Comparison of Frontline Healthcare Professionals and Other Healthcare Professionals in terms of Depression, Anxiety, Stress, Obsessive-Compulsive Symptoms and Quality of Life in the COVID-19 Pandemic. EJMI
{"title":"Comparison of Frontline Healthcare Professionals and Other Healthcare Professionals in terms of Depression, Anxiety, Stress, Obsessive-Compulsive Symptoms and Quality of Life in the COVID-19 Pandemic","authors":"zehra gunay yagci","doi":"10.14744/ejmi.2022.11975","DOIUrl":"https://doi.org/10.14744/ejmi.2022.11975","url":null,"abstract":"Objectives: In this study, we aimed to compare the healthcare workers (frontline) and other health care workers in terms of depression, anxiety, stress symptoms, obsessive-compulsive symptoms, sleep quality and quality of life. Methods: Among the doctors, nurses, assistant health personnel and medical secretaries working in Bilecik Training and Research Hospital and involved in the follow-up and treatment of COVID 19 patients. Those who accepted the study included Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Pitsburg Sleep Quality Index (PSQI), DSM 5 Posttraumatic Stress Symptoms Symptom Checklist (PCL-5), Maudsley Obsessive-Compulsive Symptom Inventory (MOCI) and World Health Organization Quality of Life Scale, Short Form (WHOQOL-BREF-TR) was given. Results: A total of 53 people were included in the study, 24 of which were in the frontline and 29 in the secondline.The number of days they worked with patients who were suspected or infected with COVID 19 and the number of those who needed mental support was significantly higher than the others. The BAI and MOCI scale scores of the frontline group were significantly higher, and the WHOQOL-BREF-TR scores were lower. Conclusion: The risk of developing psychopathology increases in all healthcare professionals, especially frontline healthcare professionals, during the pandemic period, so mental support should be provided. Abstract Article: Yagci ZG, Gol Ozcan G, Yagci T, Ceylan D. Comparison of Frontline Healthcare Professionals and Other Healthcare Professionals in terms of Depression, Anxiety, Stress, Obsessive-Compulsive Symptoms and Quality of Life in the COVID-19 Pandemic. EJMI","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123805069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intravenous Immunglobulins Are Not Effective in the Treatment of COVID-19","authors":"İ. Kılıç","doi":"10.14744/ejmi.2021.68051","DOIUrl":"https://doi.org/10.14744/ejmi.2021.68051","url":null,"abstract":"DOI: 10.14744/ejmi.2021.68051 EJMI 2021;5(4):481–485","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129937296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2023.47013
D. Erdem
Objectives: In this study, the significance of lymphocyte-C-reactive protein ratio (LCR) in indicating the prognosis/clini-cal course of patients with non-small cell lung cancer receiving immunotherapy was investigated. Methods: All patients with non-small cell lung cancer who applied to Samsun Medicalpark Medical Oncology outpatient clinic between January 2020 and September 2022 and who received immunotherapy treatments after chemotherapy were included in this retrospective study. Total of 57 patients were included in this retrospective analysis. Clinical data of patients were recorded from patient files. Results: This study was conducted with 57 patients with stage IV non-small cell lung cancer who received immunotherapy after failing to respond chemotherapy. The white blood cell, neutrophil, lymphocyte, monocyte and platelet counts of the patients who responded to the immunotherapy treatment significantly decreased after the treatment. When the pre-treatment values of patients who responded to and did not respond to immunotherapy were compared, pre-treatment white blood cell, neutrophil, C-reactive protein (CRP) and platelet to lymphocyte ratio (PLR) values were significantly higher in patients who did not respond to treatment. Pre-treatment serum albumin and LCR values were significantly higher in patients who respondedto immunotherapy. Conclusion: This study demonstrated that higher LCR values before receiving immunotherapy may be a positive prognosis indicator in stage IV non-small lung cancer patients.
{"title":"The Prognostic Significance of Lymphocyte-C-Reactive Protein Ratio in Non-Small Cell Lung Cancer Patien Receiving Immunotherapy","authors":"D. Erdem","doi":"10.14744/ejmi.2023.47013","DOIUrl":"https://doi.org/10.14744/ejmi.2023.47013","url":null,"abstract":"Objectives: In this study, the significance of lymphocyte-C-reactive protein ratio (LCR) in indicating the prognosis/clini-cal course of patients with non-small cell lung cancer receiving immunotherapy was investigated. Methods: All patients with non-small cell lung cancer who applied to Samsun Medicalpark Medical Oncology outpatient clinic between January 2020 and September 2022 and who received immunotherapy treatments after chemotherapy were included in this retrospective study. Total of 57 patients were included in this retrospective analysis. Clinical data of patients were recorded from patient files. Results: This study was conducted with 57 patients with stage IV non-small cell lung cancer who received immunotherapy after failing to respond chemotherapy. The white blood cell, neutrophil, lymphocyte, monocyte and platelet counts of the patients who responded to the immunotherapy treatment significantly decreased after the treatment. When the pre-treatment values of patients who responded to and did not respond to immunotherapy were compared, pre-treatment white blood cell, neutrophil, C-reactive protein (CRP) and platelet to lymphocyte ratio (PLR) values were significantly higher in patients who did not respond to treatment. Pre-treatment serum albumin and LCR values were significantly higher in patients who respondedto immunotherapy. Conclusion: This study demonstrated that higher LCR values before receiving immunotherapy may be a positive prognosis indicator in stage IV non-small lung cancer patients.","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130497532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2022.43781
Muzeyyen Aslaner Ak
Objectives: Chronic Lymphocytic Leukemia (CLL) is a hematological malignancy characterized by clonal proliferation and accumulation of mature, typically CD5(+) B cells in peripheral blood, bone marrow, spleen and lymph nodes. We aimed to contribute to patient approach algorithms by examining the clinical and prognostic characteristics, treatment regimens used, treatment responses, that may be effective on survival of patients diagnosed with CLL who received follow-up and treatment in our center. Methods: The study included 152 patients, who were diagnosed with CLL between January 2011 and December 2021in the Hematology Clinic of Zonguldak Bulent Ecevit University Faculty of Medicine Hospital and whose data could be accessed. Treatment responses, survival status and factors affecting overall survival (OS) were evaluated retrospectively. Results: 152 patients (89 men, 63 women) were included in the study. The median age was 66.71±9.89 years. In our study, the survival of the patients in the group with advanced age, high LDH, high risk modified RAI and advanced Binnet was found to be low and statistically significant. The mean follow-up period in all our CLL cases was 53.44 months. During the follow-up period, 87 patients did not receive any treatment, while 65 patients received treatment. Five-year overall survival was 63.6%, and disease-free survival was found to be 59.3%. Conclusion: In CLL patients the appropriate treatment should be selected at the appropriate time, taking into account the characteristics of the patient and the disease. In order to achieve complete remission, effective chemo-immuno-therapy agents should be started at the right time in patients. Abstract
{"title":"Retrospective Evaluation of Our Cases with Chronic Lymphocytic Leukemia: Single Centered Real Life Data","authors":"Muzeyyen Aslaner Ak","doi":"10.14744/ejmi.2022.43781","DOIUrl":"https://doi.org/10.14744/ejmi.2022.43781","url":null,"abstract":"Objectives: Chronic Lymphocytic Leukemia (CLL) is a hematological malignancy characterized by clonal proliferation and accumulation of mature, typically CD5(+) B cells in peripheral blood, bone marrow, spleen and lymph nodes. We aimed to contribute to patient approach algorithms by examining the clinical and prognostic characteristics, treatment regimens used, treatment responses, that may be effective on survival of patients diagnosed with CLL who received follow-up and treatment in our center. Methods: The study included 152 patients, who were diagnosed with CLL between January 2011 and December 2021in the Hematology Clinic of Zonguldak Bulent Ecevit University Faculty of Medicine Hospital and whose data could be accessed. Treatment responses, survival status and factors affecting overall survival (OS) were evaluated retrospectively. Results: 152 patients (89 men, 63 women) were included in the study. The median age was 66.71±9.89 years. In our study, the survival of the patients in the group with advanced age, high LDH, high risk modified RAI and advanced Binnet was found to be low and statistically significant. The mean follow-up period in all our CLL cases was 53.44 months. During the follow-up period, 87 patients did not receive any treatment, while 65 patients received treatment. Five-year overall survival was 63.6%, and disease-free survival was found to be 59.3%. Conclusion: In CLL patients the appropriate treatment should be selected at the appropriate time, taking into account the characteristics of the patient and the disease. In order to achieve complete remission, effective chemo-immuno-therapy agents should be started at the right time in patients. Abstract","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114631311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diabetic Neuropathy Improves After Laparoscopic Diverted Sleeve Gastrectomy With Ileal Interposition: A Single Arm Electrophysiological Follow-Up Study","authors":"E. Cagiltay, A. Celik, N. Uzun, A. Sonkaya, S. Ugale, T. Adatepe, M. Ertaş","doi":"10.14744/EJMI.2019.70975","DOIUrl":"https://doi.org/10.14744/EJMI.2019.70975","url":null,"abstract":"DOI: 10.14744/ejmi.2019.70975 EJMI 2019;3(2):103–110","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127643385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2022.33869
N. Fidan
Objectives: We aimed to present preoperative ultrasonographic features, distribution of histopathological diagnosis and molecular subtypes of malignant tumors, and to compare sonographic and pathological tumor dimensions in patients with subcentimeter breast lesions. Methods: Eighty six women with newly diagnosed breast cancer were included in the study who underwent preoperative biopsy and surgical resection between 2015 and 2020. Sonographically tumor margins were grouped as circumscribed, microlobulated, irregular-indistinct, angular and spiculated. By taking 25% of the pathological tumor size and value of ± 5 mm as cut-off, the presence of sonopathological concordance was evaluated. Results: The median tumor sizes were 10 mm (4-10 mm) sonographically and 11 mm (2-45 mm) histopathologically. The spiculated and irregular-indistinct margins were the most frequent sonog-raphic features (35% and 35%). Value of ±5 mm and 25% of the pathological tumor size acording to cut-off, the sonopathological concordance rates were calculated as 74% and 55%, the underestimation rates were 20% and 35%, the overestimation rates were 6% and 10%, respectively. Conclusion: In our study, the most common sonographic features was spiculated and irregular-indistinct margins. We found sonopathological concordance rates similar to current literature. Especially in patients with DCIS, invasive lobular carcinoma, and HER2 enriched subtype, sonopathological discordance should be considered when planning the optimal treatment. Abstract Imaging Features Histopathological Analysis in Pa- tients with Subcentimeter Breast Detected by Ultrasonography.
目的:探讨乳腺亚厘米级病变患者的术前超声特征、组织病理诊断分布及分子亚型，比较超声与病理肿瘤尺寸。方法:在2015年至2020年期间，86名新诊断的乳腺癌患者接受了术前活检和手术切除。超声检查肿瘤边缘分为有边界的、微分叶的、不规则模糊的、有角的和多刺的。以病理肿瘤大小的25%及±5mm值为截点，评价超声病理一致性的存在。结果:超声检查中位肿瘤大小为10 mm (4-10 mm)，病理组织学中位肿瘤大小为11 mm (2-45 mm)。多刺和不规则模糊边缘是最常见的声像图特征(35%和35%)。分别为病理肿瘤大小的±5 mm和25%，计算超声病理一致性率分别为74%和55%，低估率分别为20%和35%，高估率分别为6%和10%。结论:在我们的研究中，最常见的声像图特征是多刺和不规则模糊的边缘。我们发现超声病理一致性率与现有文献相似。特别是对于DCIS、浸润性小叶癌和HER2富集亚型患者，在制定最佳治疗方案时应考虑超声病理差异。超声检查亚厘米乳房的影像学特征及组织病理学分析。
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