Pub Date : 1900-01-01DOI: 10.14744/ejmi.2022.15573
Cengiz Yilmaz
To investigate the mortality rate and mortality-related factors for patients with oncological malignancies (cancer patients) hospitalized for Covid-19 infection. Methods: Demographic characteristics, hematological and biochemical parameters, lung CT Severity Scores (CT-SS), and Charlson Comorbidity Indices (CCI) of living and dead oncology patients were compared. Statistical analyses of possible factors that may impact mortality were performed. Results: The overall mortality rate of 2650 patients hospitalized for Covid-19 was 21%. Among these, 410 patients had active oncological malignancy. The mortality rate of the oncology patients was significantly higher than those without any malignancy (54% vs. 7.2%, p<0.0001). Logistic regression analyses revealed that CT-SS, neutrophil count, hemoglobin, and CCI had meaningful independent effects on mortality in patients with oncological malignancies. The mean CT-SS was significantly higher in the ex-group than the alive group (17.6±5.5 vs. 15.3±4.8, p<0.0001). On the other hand, the mean neutrophil count (2100±830 vs. 4350±660 p <0.0001) and hemoglobin level (8.4±3.2 vs. 10.7±2.8, p<0.0001) were statistically lower. Conclusion: Covid-19 (+) oncology patients suffering from profound anemia, neutropenia, and substantial lung involvement have markedly high mortality and should be treated intensely and meticulously. Abstract
目的探讨恶性肿瘤患者(肿瘤患者)因Covid-19感染住院的死亡率及死亡相关因素。方法:比较活、死肿瘤患者的人口学特征、血液学及生化指标、肺部CT严重程度评分(CT- ss)及Charlson共病指数(CCI)。对可能影响死亡率的因素进行统计分析。结果:2650例新冠肺炎住院患者的总死亡率为21%。其中410例患者有活动性肿瘤恶性肿瘤。肿瘤患者的死亡率明显高于无恶性肿瘤患者(54% vs. 7.2%， p<0.0001)。Logistic回归分析显示，CT-SS、中性粒细胞计数、血红蛋白和CCI对肿瘤恶性肿瘤患者的死亡率有显著的独立影响。退组CT-SS平均值显著高于活组(17.6±5.5比15.3±4.8,p<0.0001)。另一方面，平均中性粒细胞计数(2100±830 vs. 4350±660 p<0.0001)和血红蛋白水平(8.4±3.2 vs. 10.7±2.8,p<0.0001)均低于对照组。结论:伴有深度贫血、中性粒细胞减少、肺部严重受累的Covid-19(+)肿瘤患者死亡率明显高，应加强和精心治疗。摘要
{"title":"Mortality Rate and Related Factors in Patients with Active Oncological Malignancies Hospitalized for Covid-19","authors":"Cengiz Yilmaz","doi":"10.14744/ejmi.2022.15573","DOIUrl":"https://doi.org/10.14744/ejmi.2022.15573","url":null,"abstract":"To investigate the mortality rate and mortality-related factors for patients with oncological malignancies (cancer patients) hospitalized for Covid-19 infection. Methods: Demographic characteristics, hematological and biochemical parameters, lung CT Severity Scores (CT-SS), and Charlson Comorbidity Indices (CCI) of living and dead oncology patients were compared. Statistical analyses of possible factors that may impact mortality were performed. Results: The overall mortality rate of 2650 patients hospitalized for Covid-19 was 21%. Among these, 410 patients had active oncological malignancy. The mortality rate of the oncology patients was significantly higher than those without any malignancy (54% vs. 7.2%, p<0.0001). Logistic regression analyses revealed that CT-SS, neutrophil count, hemoglobin, and CCI had meaningful independent effects on mortality in patients with oncological malignancies. The mean CT-SS was significantly higher in the ex-group than the alive group (17.6±5.5 vs. 15.3±4.8, p<0.0001). On the other hand, the mean neutrophil count (2100±830 vs. 4350±660 p <0.0001) and hemoglobin level (8.4±3.2 vs. 10.7±2.8, p<0.0001) were statistically lower. Conclusion: Covid-19 (+) oncology patients suffering from profound anemia, neutropenia, and substantial lung involvement have markedly high mortality and should be treated intensely and meticulously. Abstract","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115859682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2019.84589
A. Şahin, A. Taşdoğan
DOI: 10.14744/ejmi.2019.84589
{"title":"Myelosuppression in Patients with Prolonged Use Of Piperacillin/Tazobactam","authors":"A. Şahin, A. Taşdoğan","doi":"10.14744/ejmi.2019.84589","DOIUrl":"https://doi.org/10.14744/ejmi.2019.84589","url":null,"abstract":"DOI: 10.14744/ejmi.2019.84589","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124063013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2021.24427
B. Oven
{"title":"Lifestyle behaviour after diagnosis of cancer","authors":"B. Oven","doi":"10.14744/ejmi.2021.24427","DOIUrl":"https://doi.org/10.14744/ejmi.2021.24427","url":null,"abstract":"","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129123673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2023.59897
A. Ozveren
Objectives: Addition of trastuzumab and pertuzumab to neoadjuvant chemotherapy in Human epidermal growth factor receptor 2 (HER-2) positive breast cancer is the current clinical standard. We aimed to determine whether anthra-cycline-containing neoadjuvant chemotherapy yields beneficial effects alongside dual HER-2 blockade, and to assess cardiotoxicity with this treatment. Methods: Fifty-two patients with HER-2-positive breast cancer who received neoadjuvant chemotherapy were retrospectively evaluated at three tertiary health-care centers. The effects of chemotherapy regimen and several other factors such as age, stage, menopause status, lymph node positivity, and hormone receptor positivity on pathological complete response (pCR) were evaluated. Results: The mean age at diagnosis was 46±9 years. The pCR rate was similar between those with and without anthra-cycline-containing regimens (71.4% vs. 70%). Subgroup analyses also showed similar pCR values for those with negative and positive hormone receptors (64.7% vs. 74.3%), those with Ki67 levels <20% and >20% (60% vs. 73.8%), and when premenopausal patients were compared with postmenopausal patients (76.9% vs. 65.4%). Conclusion: It appears that adding anthracycline to dual HER-2 blockade for neoadjuvant therapy did not yield additional benefits in terms of pCR. Further studies are needed to assess anthracycline-containing regimens in patients who will use the neoadjuvant pertuzumab-trastuzumab combination.
{"title":"Chemotherapy Choice in Neoadjuvant Dual Her2 Blockade: Is it Really Essential to Add Anthracycline?","authors":"A. Ozveren","doi":"10.14744/ejmi.2023.59897","DOIUrl":"https://doi.org/10.14744/ejmi.2023.59897","url":null,"abstract":"Objectives: Addition of trastuzumab and pertuzumab to neoadjuvant chemotherapy in Human epidermal growth factor receptor 2 (HER-2) positive breast cancer is the current clinical standard. We aimed to determine whether anthra-cycline-containing neoadjuvant chemotherapy yields beneficial effects alongside dual HER-2 blockade, and to assess cardiotoxicity with this treatment. Methods: Fifty-two patients with HER-2-positive breast cancer who received neoadjuvant chemotherapy were retrospectively evaluated at three tertiary health-care centers. The effects of chemotherapy regimen and several other factors such as age, stage, menopause status, lymph node positivity, and hormone receptor positivity on pathological complete response (pCR) were evaluated. Results: The mean age at diagnosis was 46±9 years. The pCR rate was similar between those with and without anthra-cycline-containing regimens (71.4% vs. 70%). Subgroup analyses also showed similar pCR values for those with negative and positive hormone receptors (64.7% vs. 74.3%), those with Ki67 levels <20% and >20% (60% vs. 73.8%), and when premenopausal patients were compared with postmenopausal patients (76.9% vs. 65.4%). Conclusion: It appears that adding anthracycline to dual HER-2 blockade for neoadjuvant therapy did not yield additional benefits in terms of pCR. Further studies are needed to assess anthracycline-containing regimens in patients who will use the neoadjuvant pertuzumab-trastuzumab combination.","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131073830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2023.86631
E. Kut
{"title":"Relationship Between Glucose-To-Lymphocyte, Albumin-To Alkaline Phosphatase and\u0000 Neutrophil-To-Lymphocyte Rat and Prognosis in Young Patients with Pancreatic\u0000 Cancer","authors":"E. Kut","doi":"10.14744/ejmi.2023.86631","DOIUrl":"https://doi.org/10.14744/ejmi.2023.86631","url":null,"abstract":"","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131164495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrospective Evaluation of Patients with Upper Extremity Peripheral Nerve Block","authors":"M. Mutlu","doi":"10.14744/EJMI.2021.55138","DOIUrl":"https://doi.org/10.14744/EJMI.2021.55138","url":null,"abstract":"DOI: 10.14744/ejmi.2021.55138 EJMI 2021;5(2):184–188","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"348 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131106123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2023.14125
Sidika Genc
.
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{"title":"Morinda Citrifolia Modulate Bax/Bcl-2 Ratio to Inhibition of Apoptosis Induced By 6 OHDA – in SY-5Y Cells Mode","authors":"Sidika Genc","doi":"10.14744/ejmi.2023.14125","DOIUrl":"https://doi.org/10.14744/ejmi.2023.14125","url":null,"abstract":".","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124278940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Latent Toxoplasmosis in Alzheimer’s Disease","authors":"N. Karabulut","doi":"10.14744/EJMI.2019.23480","DOIUrl":"https://doi.org/10.14744/EJMI.2019.23480","url":null,"abstract":"DOI: 10.14744/ejmi.2019.23480 EJMI 2020;4(3):380–383","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"22 11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125686718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrospective Case Series Study on Basic Epidemiological Characteristics of the Cancer Diagnosed Syrian Refugees in South of Turkey","authors":"Ayse Kotek Sedef","doi":"10.14744/ejmi.2021.20969","DOIUrl":"https://doi.org/10.14744/ejmi.2021.20969","url":null,"abstract":"DOI: 10.14744/ejmi.2021.20969 EJMI 2021;5(4):496–499","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"227 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122280103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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