Pub Date : 1900-01-01DOI: 10.14744/ejmi.2023.14125
Sidika Genc
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{"title":"Morinda Citrifolia Modulate Bax/Bcl-2 Ratio to Inhibition of Apoptosis Induced By 6 OHDA – in SY-5Y Cells Mode","authors":"Sidika Genc","doi":"10.14744/ejmi.2023.14125","DOIUrl":"https://doi.org/10.14744/ejmi.2023.14125","url":null,"abstract":".","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124278940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of Latent Toxoplasmosis in Alzheimer’s Disease","authors":"N. Karabulut","doi":"10.14744/EJMI.2019.23480","DOIUrl":"https://doi.org/10.14744/EJMI.2019.23480","url":null,"abstract":"DOI: 10.14744/ejmi.2019.23480 EJMI 2020;4(3):380–383","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"22 11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125686718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2023.18471
A. Gulmez
dif-Objectives: The pan-immune-inflammation value (PIV) is an easily calculable immune marker based on blood laboratory tests to predict prognosis in cancer patients. The primary aim of this study is to evaluate the prognostic value of PIV in metastatic human epidermal growth factor receptor 2 (HER2)-positive breast cancer (mBC) patients treated with dual block with pertuzumab. Methods: This retrospective study evaluated the relationship between PIV and other prognostic markers, progression-free survival (PFS), and overall survival (OS) in HER2-positive metastatic BC patients treated with dual block with pertuzumab. PIV was calculated as follows: neutrophil count (10 9 /L) × platelet count (10 9 /L) × monocyte count (10 9 /L)/ lymphocyte count (10 9 /L). Results: A total of 61 patients with mBC were included in this study. According to cutoff value for PIV, 31 (50.8%) and 30 (49.2%) patients fell into PIV-low <418,61 and PIV-high ≥418,61 groups, respectively. As a result of univariate analysis, high PIV was associated with worse outcome, which was statistically significant for both OS and PFS. Similarly, other IPMs were also statistically significantly associated with survival. Conclusion: This study demonstrated that pre-treatment PIV may be a prognostic biomarker in metastatic HER2-positive BC patients treated with pertuzumab.
{"title":"Pan-immune-inflammation Value in Metastatic HER2-Positive Breast Cancer Patients","authors":"A. Gulmez","doi":"10.14744/ejmi.2023.18471","DOIUrl":"https://doi.org/10.14744/ejmi.2023.18471","url":null,"abstract":"dif-Objectives: The pan-immune-inflammation value (PIV) is an easily calculable immune marker based on blood laboratory tests to predict prognosis in cancer patients. The primary aim of this study is to evaluate the prognostic value of PIV in metastatic human epidermal growth factor receptor 2 (HER2)-positive breast cancer (mBC) patients treated with dual block with pertuzumab. Methods: This retrospective study evaluated the relationship between PIV and other prognostic markers, progression-free survival (PFS), and overall survival (OS) in HER2-positive metastatic BC patients treated with dual block with pertuzumab. PIV was calculated as follows: neutrophil count (10 9 /L) × platelet count (10 9 /L) × monocyte count (10 9 /L)/ lymphocyte count (10 9 /L). Results: A total of 61 patients with mBC were included in this study. According to cutoff value for PIV, 31 (50.8%) and 30 (49.2%) patients fell into PIV-low <418,61 and PIV-high ≥418,61 groups, respectively. As a result of univariate analysis, high PIV was associated with worse outcome, which was statistically significant for both OS and PFS. Similarly, other IPMs were also statistically significantly associated with survival. Conclusion: This study demonstrated that pre-treatment PIV may be a prognostic biomarker in metastatic HER2-positive BC patients treated with pertuzumab.","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129224330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrospective Evaluation of Patients with Upper Extremity Peripheral Nerve Block","authors":"M. Mutlu","doi":"10.14744/EJMI.2021.55138","DOIUrl":"https://doi.org/10.14744/EJMI.2021.55138","url":null,"abstract":"DOI: 10.14744/ejmi.2021.55138 EJMI 2021;5(2):184–188","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"348 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131106123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/EJMI.2018.28247
Alper Þen, Kadir Özdamar, Ataman Gönel
EJMI DOI: 10.14744/ejmi.2018.28247
EJMI DOI: 10.14744/ejmi.2018.28247
{"title":"Examination of oxidative stress with thiol-disulphide homeostasis in pediatric cases with otitis media with effusion: a case-control study.","authors":"Alper Þen, Kadir Özdamar, Ataman Gönel","doi":"10.14744/EJMI.2018.28247","DOIUrl":"https://doi.org/10.14744/EJMI.2018.28247","url":null,"abstract":"EJMI DOI: 10.14744/ejmi.2018.28247","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"129 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130086152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2022.15573
Cengiz Yilmaz
To investigate the mortality rate and mortality-related factors for patients with oncological malignancies (cancer patients) hospitalized for Covid-19 infection. Methods: Demographic characteristics, hematological and biochemical parameters, lung CT Severity Scores (CT-SS), and Charlson Comorbidity Indices (CCI) of living and dead oncology patients were compared. Statistical analyses of possible factors that may impact mortality were performed. Results: The overall mortality rate of 2650 patients hospitalized for Covid-19 was 21%. Among these, 410 patients had active oncological malignancy. The mortality rate of the oncology patients was significantly higher than those without any malignancy (54% vs. 7.2%, p<0.0001). Logistic regression analyses revealed that CT-SS, neutrophil count, hemoglobin, and CCI had meaningful independent effects on mortality in patients with oncological malignancies. The mean CT-SS was significantly higher in the ex-group than the alive group (17.6±5.5 vs. 15.3±4.8, p<0.0001). On the other hand, the mean neutrophil count (2100±830 vs. 4350±660 p <0.0001) and hemoglobin level (8.4±3.2 vs. 10.7±2.8, p<0.0001) were statistically lower. Conclusion: Covid-19 (+) oncology patients suffering from profound anemia, neutropenia, and substantial lung involvement have markedly high mortality and should be treated intensely and meticulously. Abstract
目的探讨恶性肿瘤患者(肿瘤患者)因Covid-19感染住院的死亡率及死亡相关因素。方法:比较活、死肿瘤患者的人口学特征、血液学及生化指标、肺部CT严重程度评分(CT- ss)及Charlson共病指数(CCI)。对可能影响死亡率的因素进行统计分析。结果:2650例新冠肺炎住院患者的总死亡率为21%。其中410例患者有活动性肿瘤恶性肿瘤。肿瘤患者的死亡率明显高于无恶性肿瘤患者(54% vs. 7.2%， p<0.0001)。Logistic回归分析显示，CT-SS、中性粒细胞计数、血红蛋白和CCI对肿瘤恶性肿瘤患者的死亡率有显著的独立影响。退组CT-SS平均值显著高于活组(17.6±5.5比15.3±4.8,p<0.0001)。另一方面，平均中性粒细胞计数(2100±830 vs. 4350±660 p<0.0001)和血红蛋白水平(8.4±3.2 vs. 10.7±2.8,p<0.0001)均低于对照组。结论:伴有深度贫血、中性粒细胞减少、肺部严重受累的Covid-19(+)肿瘤患者死亡率明显高，应加强和精心治疗。摘要
{"title":"Mortality Rate and Related Factors in Patients with Active Oncological Malignancies Hospitalized for Covid-19","authors":"Cengiz Yilmaz","doi":"10.14744/ejmi.2022.15573","DOIUrl":"https://doi.org/10.14744/ejmi.2022.15573","url":null,"abstract":"To investigate the mortality rate and mortality-related factors for patients with oncological malignancies (cancer patients) hospitalized for Covid-19 infection. Methods: Demographic characteristics, hematological and biochemical parameters, lung CT Severity Scores (CT-SS), and Charlson Comorbidity Indices (CCI) of living and dead oncology patients were compared. Statistical analyses of possible factors that may impact mortality were performed. Results: The overall mortality rate of 2650 patients hospitalized for Covid-19 was 21%. Among these, 410 patients had active oncological malignancy. The mortality rate of the oncology patients was significantly higher than those without any malignancy (54% vs. 7.2%, p<0.0001). Logistic regression analyses revealed that CT-SS, neutrophil count, hemoglobin, and CCI had meaningful independent effects on mortality in patients with oncological malignancies. The mean CT-SS was significantly higher in the ex-group than the alive group (17.6±5.5 vs. 15.3±4.8, p<0.0001). On the other hand, the mean neutrophil count (2100±830 vs. 4350±660 p <0.0001) and hemoglobin level (8.4±3.2 vs. 10.7±2.8, p<0.0001) were statistically lower. Conclusion: Covid-19 (+) oncology patients suffering from profound anemia, neutropenia, and substantial lung involvement have markedly high mortality and should be treated intensely and meticulously. Abstract","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115859682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrospective Case Series Study on Basic Epidemiological Characteristics of the Cancer Diagnosed Syrian Refugees in South of Turkey","authors":"Ayse Kotek Sedef","doi":"10.14744/ejmi.2021.20969","DOIUrl":"https://doi.org/10.14744/ejmi.2021.20969","url":null,"abstract":"DOI: 10.14744/ejmi.2021.20969 EJMI 2021;5(4):496–499","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"227 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122280103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of Efficacy, Reliability, Side Effects and Patient Compliance of Entecavir in Turkish Patients with Nukleos(T)ide Analogues Naive Chronic Hepatitis B","authors":"M. Karaağaç, Nevzat Aksoy, Kemal Kutoğlu, N. Arican, Semih Kalyon, N. Yenice","doi":"10.14744/EJMI.2019.70738","DOIUrl":"https://doi.org/10.14744/EJMI.2019.70738","url":null,"abstract":"DOI: 10.14744/ejmi.2019.70738 EJMI 2019;3(4):322–326","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122328495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.14744/ejmi.2019.84589
A. Şahin, A. Taşdoğan
DOI: 10.14744/ejmi.2019.84589
{"title":"Myelosuppression in Patients with Prolonged Use Of Piperacillin/Tazobactam","authors":"A. Şahin, A. Taşdoğan","doi":"10.14744/ejmi.2019.84589","DOIUrl":"https://doi.org/10.14744/ejmi.2019.84589","url":null,"abstract":"DOI: 10.14744/ejmi.2019.84589","PeriodicalId":310818,"journal":{"name":"Eurasian Journal of Medical Investigation","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124063013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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