Experiments using rubber/resin foam (RB) have already shown that far-infrared rays suppress the proliferation of cancer cells. We will report as a follow up to these findings. When RB was used, the temperature of the culture solution increased by about 0.4°C. This time, with a focus on this temperature rise, a new heating plate was manufactured, and culture experiments were conducted without using RB. It was determined that the suppression of growth was because of heat transfer, not due to the special action of RB. The distribution of heat was calculated using Planck’s formula, and it was speculated that mid-infrared rays around 4.8 µm are involved in the inhibition of cancer cell proliferation. Furthermore, irradiation with a 4.8 µm mid-infrared free electron laser confirmed that the ratio of α-helix to β-sheet changed, providing corroborative evidence for growth suppression.
{"title":"Suppression of Prostate Cancer Cell Growth by Mid-Infrared Rays","authors":"","doi":"10.33140/ijcrt.07.04.02","DOIUrl":"https://doi.org/10.33140/ijcrt.07.04.02","url":null,"abstract":"Experiments using rubber/resin foam (RB) have already shown that far-infrared rays suppress the proliferation of cancer cells. We will report as a follow up to these findings. When RB was used, the temperature of the culture solution increased by about 0.4°C. This time, with a focus on this temperature rise, a new heating plate was manufactured, and culture experiments were conducted without using RB. It was determined that the suppression of growth was because of heat transfer, not due to the special action of RB. The distribution of heat was calculated using Planck’s formula, and it was speculated that mid-infrared rays around 4.8 µm are involved in the inhibition of cancer cell proliferation. Furthermore, irradiation with a 4.8 µm mid-infrared free electron laser confirmed that the ratio of α-helix to β-sheet changed, providing corroborative evidence for growth suppression.","PeriodicalId":310821,"journal":{"name":"International Journal of Cancer Research & Therapy","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131047314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The average age of people who have neck cancer is 59 years. In general, cancer of the salivary glands or thyroid affects people under the age of 59, and cancer of the mouth, throat and larynx affects those over the age of 59. Usually, head and neck cancer first spreads to nearby lymph nodes. These forms of cancer do not usually spread to other parts of the body for 6 months to 3 years. Metastases usually arise from large or persistent tumors and are more likely to develop in people who have a weakened immune system. Treatment depends on the stage of the cancer. Stage I cancer, regardless of location, responds similarly to surgical treatment and radiation. Usually, radiation targets not only the cancer but also the lymph nodes on the circumference of the neck because more than 20% of such cancers spread to the lymph nodes.
{"title":"The Treatment of Neck Cancer Depends on the Stage of the Cancer","authors":"","doi":"10.33140/ijcrt.07.03.07","DOIUrl":"https://doi.org/10.33140/ijcrt.07.03.07","url":null,"abstract":"The average age of people who have neck cancer is 59 years. In general, cancer of the salivary glands or thyroid affects people under the age of 59, and cancer of the mouth, throat and larynx affects those over the age of 59. Usually, head and neck cancer first spreads to nearby lymph nodes. These forms of cancer do not usually spread to other parts of the body for 6 months to 3 years. Metastases usually arise from large or persistent tumors and are more likely to develop in people who have a weakened immune system. Treatment depends on the stage of the cancer. Stage I cancer, regardless of location, responds similarly to surgical treatment and radiation. Usually, radiation targets not only the cancer but also the lymph nodes on the circumference of the neck because more than 20% of such cancers spread to the lymph nodes.","PeriodicalId":310821,"journal":{"name":"International Journal of Cancer Research & Therapy","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121797053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction Malignant ovarian cancer is the fifth most common cause of death in women in developed nations. According to traditional Chinese medicine, cancer is formed when the internal energy is reduced and also with the formation of internal Fire. The use of highly concentrated medications (in this case hormones in the intra-uterine device) can reduce the vital energy of the patient and lead to the formation of internal Fire and have more propensity to develop cancer. The purpose of this study is to demonstrate that patients with malignant ovary cancer have energy deficiency inside the five internal massive organs and the formation of internal Fire and the use of the Mirena intrauterine device (LNG-IUD) can induce more energy deficiency (according to Arndt-Shultz Law), predisposing the patient to have more propensity to have cancer, in this case, malignant ovary cancer. Methods one case report of a 42 years-old female patient, that was using the intra-uterine device for 10 years without interruption (she used the first for 5 years and the second for 5 more years). She discovered that one ovary had cysts in one specific exam and in the first measurement, she discovered that these cysts were increasing in size and the doctor decided to do the biopsy through video laparoscopy which revealed that was a malignant ovary tumor. She underwent surgery to remove completely the ovaries and uterus. She went to my clinic to treat headache symptoms and I measured her internal five massive organs’ energy using the radiesthesia procedure. Results All the internal five massive organs were in the lowest level of energy, rated one out of eight and the treatment consisted of changes in her dietary habit through the teachings of Chinese dietary nutrition, auricular acupuncture with apex ear bloodletting to rebalance the Yin, Yang, Qi and Blood energies and replenish the internal massive organs energy using homeopathy medications according to the theory Constitutional Homeopathy of the Five Elements Based on Traditional Chinese Medicine and crystal-based medications. Conclusion The conclusion of this study is to demonstrate that patients with malignant ovary tumors have energy deficiency inside the five internal massive organs and the use of an intra-uterine device (that has progesterone hormones, considered highly concentrated medications), will reduce even more this vital energy and increase the chance to develop malignant tumor inside the patient’s body, in this case, malignant ovary tumor. So, the use of highly diluted medications will increase the energy of the patients and will reduce the chance to have any other malignant tumor and also, the formation of metastasis.
{"title":"Malignant Ovarian Cancer Secondary to the Chronic Use of Mirena Intrauterine Device","authors":"","doi":"10.33140/ijcrt.07.03.08","DOIUrl":"https://doi.org/10.33140/ijcrt.07.03.08","url":null,"abstract":"Introduction Malignant ovarian cancer is the fifth most common cause of death in women in developed nations. According to traditional Chinese medicine, cancer is formed when the internal energy is reduced and also with the formation of internal Fire. The use of highly concentrated medications (in this case hormones in the intra-uterine device) can reduce the vital energy of the patient and lead to the formation of internal Fire and have more propensity to develop cancer. The purpose of this study is to demonstrate that patients with malignant ovary cancer have energy deficiency inside the five internal massive organs and the formation of internal Fire and the use of the Mirena intrauterine device (LNG-IUD) can induce more energy deficiency (according to Arndt-Shultz Law), predisposing the patient to have more propensity to have cancer, in this case, malignant ovary cancer. Methods one case report of a 42 years-old female patient, that was using the intra-uterine device for 10 years without interruption (she used the first for 5 years and the second for 5 more years). She discovered that one ovary had cysts in one specific exam and in the first measurement, she discovered that these cysts were increasing in size and the doctor decided to do the biopsy through video laparoscopy which revealed that was a malignant ovary tumor. She underwent surgery to remove completely the ovaries and uterus. She went to my clinic to treat headache symptoms and I measured her internal five massive organs’ energy using the radiesthesia procedure. Results All the internal five massive organs were in the lowest level of energy, rated one out of eight and the treatment consisted of changes in her dietary habit through the teachings of Chinese dietary nutrition, auricular acupuncture with apex ear bloodletting to rebalance the Yin, Yang, Qi and Blood energies and replenish the internal massive organs energy using homeopathy medications according to the theory Constitutional Homeopathy of the Five Elements Based on Traditional Chinese Medicine and crystal-based medications. Conclusion The conclusion of this study is to demonstrate that patients with malignant ovary tumors have energy deficiency inside the five internal massive organs and the use of an intra-uterine device (that has progesterone hormones, considered highly concentrated medications), will reduce even more this vital energy and increase the chance to develop malignant tumor inside the patient’s body, in this case, malignant ovary tumor. So, the use of highly diluted medications will increase the energy of the patients and will reduce the chance to have any other malignant tumor and also, the formation of metastasis.","PeriodicalId":310821,"journal":{"name":"International Journal of Cancer Research & Therapy","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132897453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A series of imine derivatives (3a-m) including thio-semicarbazone, semicarbazone, thiazole and oxazole functional moieties were examined for anti-cancer activity in-vitro by MTT assay using glioblastoma cell line (U87). Among all compound 3m was most potent compound with IC50 value of 8.86 ± 0.15 µM. Cytotoxicity of compounds were evaluated using normal human embryonic kidney cell line i.e HEK-293. Moreover, antibacterial activity of synthesized derivatives was also evaluated by disc diffusion method.
{"title":"Anticancer and antimicrobial activities of Imine containing compounds","authors":"S. Qazia, Asia Naz, Aneela Javedc","doi":"10.33140/ijcrt.07.03.05","DOIUrl":"https://doi.org/10.33140/ijcrt.07.03.05","url":null,"abstract":"A series of imine derivatives (3a-m) including thio-semicarbazone, semicarbazone, thiazole and oxazole functional moieties were examined for anti-cancer activity in-vitro by MTT assay using glioblastoma cell line (U87). Among all compound 3m was most potent compound with IC50 value of 8.86 ± 0.15 µM. Cytotoxicity of compounds were evaluated using normal human embryonic kidney cell line i.e HEK-293. Moreover, antibacterial activity of synthesized derivatives was also evaluated by disc diffusion method.","PeriodicalId":310821,"journal":{"name":"International Journal of Cancer Research & Therapy","volume":"147 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114421595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Srinivasulu, Mr. Anand Kumar Gupta, Dr. Kamal Kant Hiran, Dr. Tarkeswar Barua, Mr., G. Sreenivasulu, Dr. Sivaram Rajeyyagari, Dr. Madhusudhana Subramanyam
The OMICRON case that tainted human beings become first observed in China towards the end of 2021. From that point, OMICRON has spread practically all nations on the planet. To conquer this issue, it requires a fast work to recognize people tainted with OMICRON all the more rapidly. This research article proposes that RNN techniques to be utilized for rapid detection and predicting of OMICRON infections. RNN is finished utilizing the Elman agency and implemented to the OMICRON dataset gathered from Kaggle. The dataset accommodates of 75% preparing information and 25% analyzing information. The learning boundaries utilized were the most extreme age, secret hubs, and late learning. Results are for this exploration results show the level of precision is 88.28. Oddity is one of the elective conclusions for potential OMICRON illness is Recurrent Neural Network (RNN).
{"title":"Omicron Virus Data Analytics Using Extended RNN Technique","authors":"A. Srinivasulu, Mr. Anand Kumar Gupta, Dr. Kamal Kant Hiran, Dr. Tarkeswar Barua, Mr., G. Sreenivasulu, Dr. Sivaram Rajeyyagari, Dr. Madhusudhana Subramanyam","doi":"10.33140/ijcrt.07.03.02","DOIUrl":"https://doi.org/10.33140/ijcrt.07.03.02","url":null,"abstract":"The OMICRON case that tainted human beings become first observed in China towards the end of 2021. From that point, OMICRON has spread practically all nations on the planet. To conquer this issue, it requires a fast work to recognize people tainted with OMICRON all the more rapidly. This research article proposes that RNN techniques to be utilized for rapid detection and predicting of OMICRON infections. RNN is finished utilizing the Elman agency and implemented to the OMICRON dataset gathered from Kaggle. The dataset accommodates of 75% preparing information and 25% analyzing information. The learning boundaries utilized were the most extreme age, secret hubs, and late learning. Results are for this exploration results show the level of precision is 88.28. Oddity is one of the elective conclusions for potential OMICRON illness is Recurrent Neural Network (RNN).","PeriodicalId":310821,"journal":{"name":"International Journal of Cancer Research & Therapy","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131921031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam M. Nyanda, Madalitso M Mlozen, E. Bonya, Exton Siyano, P. Chagwa, Chikondi Kamwendo, Jonathan Majamanda, Wilfred Taika, Linly Linje, Martin Henderson Kalumbi, R. Chinyama, Zefaniah Katuah, Blessings Katiniche
Background: Diabetes mellitus (DM), a group of metabolic disorders characterised by hyperglycaemia, has been attributed to increased activity of α-amylase, one of the key enzymes in carbohydrate metabolism. Alpha amylase inhibition can potentially control postprandial hyperglycaemia, hence significant in the management of diabetes mellitus, especially type 2. Acarbose, the proven α-amylase inhibitor, has been associated with several side effects. Plants used in traditional medicine represent a valuable source in the search for an alternative. The study aimed at determining the combined effect of Piliostigma thonningii and Annona senegalensis leaf extracts on alpha amylase activity. Methodology: Mortar and pestle were used to crush the leaves into powder. The fine powder was dispensed in distilled water. Percolation was used to filter the crude extract, evaporated in a water bath at 65 0C to concentrate the extract then reconstituted. Spectrophotometric assay method was used for alpha amylase activity at 540 nm. Results: The results of the study showed that A. senegalensis inhibited α-amylase by 27%, 32% and 34% at 15, 30 and 45 minutes respectively. P. thonningii exhibited inhibitory effects on α-amylase by 25%, 27% and 37% at 15, 30 and 45 minutes respectively. The combined inhibitory effects of A. senegalensis and P. thonningii on α-amylase were 28%, 37% and 62% at 15, 30 and 45 minutes respectively which are significantly different (p <0.05) from that of the positive control, acarbose (71% at 45 minutes) Conclusion: This study revealed the increased strength to inhibit alpha amylase enzyme by a combination of A. senegalensis and P. thonningii and a proportional increase in the inhibitory effect with increase in incubation time than their individual potential to inhibit alpha amylase.
{"title":"In Vitro Combined Effect of Annona Senegalensis and Piliostigma Thonningii Leaf Extracts on Alpha Amylase Activity","authors":"Adam M. Nyanda, Madalitso M Mlozen, E. Bonya, Exton Siyano, P. Chagwa, Chikondi Kamwendo, Jonathan Majamanda, Wilfred Taika, Linly Linje, Martin Henderson Kalumbi, R. Chinyama, Zefaniah Katuah, Blessings Katiniche","doi":"10.33140/ijcrt.07.03.04","DOIUrl":"https://doi.org/10.33140/ijcrt.07.03.04","url":null,"abstract":"Background: Diabetes mellitus (DM), a group of metabolic disorders characterised by hyperglycaemia, has been attributed to increased activity of α-amylase, one of the key enzymes in carbohydrate metabolism. Alpha amylase inhibition can potentially control postprandial hyperglycaemia, hence significant in the management of diabetes mellitus, especially type 2. Acarbose, the proven α-amylase inhibitor, has been associated with several side effects. Plants used in traditional medicine represent a valuable source in the search for an alternative. The study aimed at determining the combined effect of Piliostigma thonningii and Annona senegalensis leaf extracts on alpha amylase activity. Methodology: Mortar and pestle were used to crush the leaves into powder. The fine powder was dispensed in distilled water. Percolation was used to filter the crude extract, evaporated in a water bath at 65 0C to concentrate the extract then reconstituted. Spectrophotometric assay method was used for alpha amylase activity at 540 nm. Results: The results of the study showed that A. senegalensis inhibited α-amylase by 27%, 32% and 34% at 15, 30 and 45 minutes respectively. P. thonningii exhibited inhibitory effects on α-amylase by 25%, 27% and 37% at 15, 30 and 45 minutes respectively. The combined inhibitory effects of A. senegalensis and P. thonningii on α-amylase were 28%, 37% and 62% at 15, 30 and 45 minutes respectively which are significantly different (p <0.05) from that of the positive control, acarbose (71% at 45 minutes) Conclusion: This study revealed the increased strength to inhibit alpha amylase enzyme by a combination of A. senegalensis and P. thonningii and a proportional increase in the inhibitory effect with increase in incubation time than their individual potential to inhibit alpha amylase.","PeriodicalId":310821,"journal":{"name":"International Journal of Cancer Research & Therapy","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131774325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Madalitso M Mlozen, E. Bonya, Exton Siyano, Adam M. Nyanda, Charity Mkwanda, Alinafe Kululanga, Jonathan Majamanda, Wilfred Taika, Linly Linje, Martin Henderson Kalumbi, P. Chagwa, R. Chinyama, Zefaniah Katuah, Chikondi Kamwendo, Blessings Katiniche
Background: Xanthine Oxidase activity may increase plasma urates, superoxide radicals and hydrogen peroxide leading to gout, arthritis and cancer. Allopurinol, a known Xanthine Oxidase inhibitor, is noted to have various adverse effects. Many laboratories are in research projects to find alternative inhibitors of XO including plant sources. Plants are known to contain therapeutically effective agents. A. senegalensis, M. sapientum L and M. Pumila are reported to contain phytochemicals with antioxidant, anti-inflammatory and enzyme inhibitory activities. Methods: Aqueous extracts of Root bark of A. senegalensis, peels of M. sapientum L and M. pumila were assayed for their inhibitory effects on Xanthine oxidase in vitro Results: All aqueous extracts exhibited the presence of flavonoids. A. senegalensis root bark and M sapientum L and M pumila peels were investigated for their effects on Xanthine Oxidase activity. A. senegalensis root bark, M. sapientum L and M. Pumila peel extracts inhibited Xanthine Oxidase activity by 83%, 90% and 61% respectively as which are significantly different (p <0.05) from that of the positive control, allopurinol (65%) Conclusions: The results obtained in this study suggest that the flavonoids found in A. senegalensis root bark and M. sapientum L and M. pumila peel extracts could be potential Xanthine Oxidase activity inhibitors.
{"title":"In Vitro Effects of Annona Senegalensis Root Bark, Musa Sapientum L and Malus Pumila Peel Extracts On Xanthine Oxidase","authors":"Madalitso M Mlozen, E. Bonya, Exton Siyano, Adam M. Nyanda, Charity Mkwanda, Alinafe Kululanga, Jonathan Majamanda, Wilfred Taika, Linly Linje, Martin Henderson Kalumbi, P. Chagwa, R. Chinyama, Zefaniah Katuah, Chikondi Kamwendo, Blessings Katiniche","doi":"10.33140/ijcrt.07.02.09","DOIUrl":"https://doi.org/10.33140/ijcrt.07.02.09","url":null,"abstract":"Background: Xanthine Oxidase activity may increase plasma urates, superoxide radicals and hydrogen peroxide leading to gout, arthritis and cancer. Allopurinol, a known Xanthine Oxidase inhibitor, is noted to have various adverse effects. Many laboratories are in research projects to find alternative inhibitors of XO including plant sources. Plants are known to contain therapeutically effective agents. A. senegalensis, M. sapientum L and M. Pumila are reported to contain phytochemicals with antioxidant, anti-inflammatory and enzyme inhibitory activities. Methods: Aqueous extracts of Root bark of A. senegalensis, peels of M. sapientum L and M. pumila were assayed for their inhibitory effects on Xanthine oxidase in vitro Results: All aqueous extracts exhibited the presence of flavonoids. A. senegalensis root bark and M sapientum L and M pumila peels were investigated for their effects on Xanthine Oxidase activity. A. senegalensis root bark, M. sapientum L and M. Pumila peel extracts inhibited Xanthine Oxidase activity by 83%, 90% and 61% respectively as which are significantly different (p <0.05) from that of the positive control, allopurinol (65%) Conclusions: The results obtained in this study suggest that the flavonoids found in A. senegalensis root bark and M. sapientum L and M. pumila peel extracts could be potential Xanthine Oxidase activity inhibitors.","PeriodicalId":310821,"journal":{"name":"International Journal of Cancer Research & Therapy","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124562517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Apoptosis is a type of cell death. It is also called programmed cell death because the cells follow a series of instructions that tell them how to die. These instructions allow the cell to die without damaging the healthy cells around it. A cell that dies by apoptosis is called an apoptotic cell or apoptotic body. Over time, all healthy cells age and become damaged, and some of these cells will naturally go through this type of cell death. In other circumstances, the body uses this process to get rid of cells that are no longer needed.
{"title":"Briefly about Apoptosis","authors":"","doi":"10.33140/ijcrt.07.02.05","DOIUrl":"https://doi.org/10.33140/ijcrt.07.02.05","url":null,"abstract":"Apoptosis is a type of cell death. It is also called programmed cell death because the cells follow a series of instructions that tell them how to die. These instructions allow the cell to die without damaging the healthy cells around it. A cell that dies by apoptosis is called an apoptotic cell or apoptotic body. Over time, all healthy cells age and become damaged, and some of these cells will naturally go through this type of cell death. In other circumstances, the body uses this process to get rid of cells that are no longer needed.","PeriodicalId":310821,"journal":{"name":"International Journal of Cancer Research & Therapy","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116883628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I saw a 68yo gentleman 2 weeks ago that had a basal cell cancer on the left side of his face. I had seen him previously last year and had prescribed curaderm ointment for the basal cell. The curaderm appeared to clear the face up completely after it had eaten into the flesh, created a small crater like Indention and then healed over. However, over the last couple of months the basal cell came back.
B. Nayak, A. Padhy, J. Mohapatra, M. Mohapatra, J. Parija, R. Das, S. Mohanty, S. Pattnaik, S. Giri, N. Panda, S. N. Senapathi, L. Pattnaik, L. Sarangi, S. Padhi, S. Samantray, S. Panda, N. Rout, Kar, L. Das, Duttaswar Hota, Puspanjali Mohapatra, P. Devi
Aim and Objective: An clinicopathological and survival analysis 22 cases cases of no squamous carcinomas of cervix from2010- 2020 Primary objective: is to analyse the extent of microscopic parametrial involvement in early invasive non squamous carcinoma with respect to age,size of lesion,depth of invasion. To analyse the nodal status in clinically early invasive nonsquamous carcinoma with respect to other variable i.e age, tumor size, depth of invasion, parametrial involvement. Secondary Objective: was to analyse the survival status, of after radical hysterectomy and adjuvant therapy. Material and Methods: The hps confirmed cases of no squamous carcinoma of cervix were included in the study and few cases were ihc confirmed. Inclusion Criteria: Primary non-squamous carcinoma of cervix hps confirmed. Exclusion Criteria: Squamous carcinoma and metastatic carcinoma of cervix Methods: Regression analysis chi square, log rank test. Kaplan Meyers curve was used for survival analysis. Results: On regression analysis with dependent variable as the pelvic node was analysed with age, depth of invasion and size of lesion and parametrium, none of factors were significantly influencing the nodal status. Similarly, the parametrium positivity taken as the dependent variable was analysed with age, size of lesion, depth of invasion. None of the factors could predict the parametrial involvement. Overall 5-year survival probability for the patients is 0.770 i.e 55 months with 95% CI (0.570, 1.000). Here, the 5-year survival probability for the patients with parametrium positive status is 0.917i.e 48 months 95% CI (0.773, 1.000). The log rank test for change in survival between two parametrium groups i.e., negative and positive patients gives chi-square value 3.59 (d.f =1, p-value = 0.06), which indicates two groups do not differ in their survival. Disease free survival of the parametrium –ve/ parametium+ve(60/24 mths). The log rank test for change in survival between two parametrium groups i.e., negative and positive patients gives chi-square value 2.8 (d.f.=1, p-value = 0.1), which indicates two groups do not differ in their disease free survival.
{"title":"An Clinicopathological and Survival Analysis of Non-Squamous Cervical Cancers at Ahpgic","authors":"B. Nayak, A. Padhy, J. Mohapatra, M. Mohapatra, J. Parija, R. Das, S. Mohanty, S. Pattnaik, S. Giri, N. Panda, S. N. Senapathi, L. Pattnaik, L. Sarangi, S. Padhi, S. Samantray, S. Panda, N. Rout, Kar, L. Das, Duttaswar Hota, Puspanjali Mohapatra, P. Devi","doi":"10.33140/ijcrt.07.02.08","DOIUrl":"https://doi.org/10.33140/ijcrt.07.02.08","url":null,"abstract":"Aim and Objective: An clinicopathological and survival analysis 22 cases cases of no squamous carcinomas of cervix from2010- 2020 Primary objective: is to analyse the extent of microscopic parametrial involvement in early invasive non squamous carcinoma with respect to age,size of lesion,depth of invasion. To analyse the nodal status in clinically early invasive nonsquamous carcinoma with respect to other variable i.e age, tumor size, depth of invasion, parametrial involvement. Secondary Objective: was to analyse the survival status, of after radical hysterectomy and adjuvant therapy. Material and Methods: The hps confirmed cases of no squamous carcinoma of cervix were included in the study and few cases were ihc confirmed. Inclusion Criteria: Primary non-squamous carcinoma of cervix hps confirmed. Exclusion Criteria: Squamous carcinoma and metastatic carcinoma of cervix Methods: Regression analysis chi square, log rank test. Kaplan Meyers curve was used for survival analysis. Results: On regression analysis with dependent variable as the pelvic node was analysed with age, depth of invasion and size of lesion and parametrium, none of factors were significantly influencing the nodal status. Similarly, the parametrium positivity taken as the dependent variable was analysed with age, size of lesion, depth of invasion. None of the factors could predict the parametrial involvement. Overall 5-year survival probability for the patients is 0.770 i.e 55 months with 95% CI (0.570, 1.000). Here, the 5-year survival probability for the patients with parametrium positive status is 0.917i.e 48 months 95% CI (0.773, 1.000). The log rank test for change in survival between two parametrium groups i.e., negative and positive patients gives chi-square value 3.59 (d.f =1, p-value = 0.06), which indicates two groups do not differ in their survival. Disease free survival of the parametrium –ve/ parametium+ve(60/24 mths). The log rank test for change in survival between two parametrium groups i.e., negative and positive patients gives chi-square value 2.8 (d.f.=1, p-value = 0.1), which indicates two groups do not differ in their disease free survival.","PeriodicalId":310821,"journal":{"name":"International Journal of Cancer Research & Therapy","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130693947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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