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Readiness of Health Workers to Provide Pregnancy Planning Program for Women Infected with Human Immunodeficiency Virus: A Case Study in Surabaya, East Java, Indonesia 卫生工作者准备为感染人类免疫缺陷病毒的妇女提供怀孕计划方案:印度尼西亚东爪哇泗水的案例研究
Pub Date : 2021-03-31 DOI: 10.15850/AMJ.V8N1.2087
Made Chindy Dwiyanti Marheni Putri, Pudji Lestari, M. Akbar
Background: The prevalence of human immunodeficiency virus (HIV) mother-to-child infection, or vertical transmission of HIV, in Indonesia is about 90%. Ministry of Health of the Republic of Indonesia Regulation No. 21 of 2013 stated that HIV infection in sexual productive age needs integrative professional help to lower the transmissions, including voluntary counseling and testing for pregnant women as well as all people at risk. This study aimed to determine the readiness of health workers to provide pregnancy planning program service for women with HIV.Methods: This study was a descriptive study involving 30 obstetricians and 30 residents of Obstetrics and Gynecology specialist education in Surabaya, Indonesia. The respondents’ knowledge on pregnancy planning for HIV-infected women based on based on guidance released by the Ministry of Health of Indonesia in 2017 and Regulation of Ministry of Health no. 52 the year 2017, as well as their attitude and readiness to provide pregnancy planning services, was explored. Questionnaires were distributed from August to December 2019 and the data collected were analyzed using Statistical Package for the Social Science (SPSS) version 17.0 and results were described in percentage.Results: Most health workers (80%) had good knowledge on providing pregnancy planning program for HIV positive women; however, only 63.3% had good attitude towards it. The majority of respondents (90%) were ready to help HIV patients in planning their pregnancy. Conclusion: Health workers in Surabaya are ready to provide services related to pregnancy planning for women infected with HIV.
背景:人类免疫缺陷病毒(HIV)母婴感染或HIV垂直传播在印度尼西亚的流行率约为90%。印度尼西亚共和国卫生部2013年第21号条例指出,在性生育年龄感染艾滋病毒需要综合专业帮助,以降低传播,包括为孕妇和所有高危人群提供自愿咨询和检测。本研究旨在确定卫生工作者为感染艾滋病毒的妇女提供怀孕计划方案服务的准备情况。方法:本研究是一项描述性研究,涉及印度尼西亚泗水市30名产科医生和30名接受妇产科专科教育的住院医生。根据印度尼西亚卫生部2017年发布的指导意见和卫生部第6号条例,受访者对艾滋病毒感染妇女怀孕计划的了解情况。以及她们对提供计划生育服务的态度和准备情况进行了探讨。调查问卷于2019年8月至12月发放,收集到的数据使用SPSS 17.0版本进行分析,结果以百分比描述。结果:大多数卫生工作者(80%)对为艾滋病毒阳性妇女提供妊娠计划方案有较好的了解;然而,只有63.3%的人对此持良好态度。大多数答复者(90%)愿意帮助艾滋病毒患者计划怀孕。结论:泗水的卫生工作者已准备好为感染艾滋病毒的妇女提供与怀孕计划有关的服务。
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引用次数: 1
Relationship between Narcissism, Self-Esteem, and Social Media Addiction in Preclinical Medical Students 临床前医学院学生自恋、自尊与社交媒体成瘾的关系
Pub Date : 2021-03-31 DOI: 10.15850/AMJ.V8N1.2097
Helen Susanto, Eva Suryani, Yunisa Astiarani, Felicia Kurniawan
Background: Narcissism is a condition in which people have a constant demand to be complimented and prioritized. Self-esteem is a subjective evaluation of one's worth. Several studies have linked narcissism and low self-esteem as a risk factor of social media addiction, a disorder where individuals displayed an unhealthy compulsion to access social media until it disrupts other activities. This study aimed to discover the relationship between narcissism, self-esteem, and social media addiction in preclinical medical students. Methods: This study was a cross-sectional observational analytical study on 211 preclinical medical students at the Atma Jaya Catholic University of Indonesia. Instruments used in this study were Narcissistic Personality Inventory-16 (NPI-16), Rosenberg Self-Esteem Scale (RSES), and Bergen Social Media Addiction Scale (BSMAS). Data were analyzed statistically using Chi-square in STATA analytic program.Results: Of all respondents, 6.6% were narcissistic, 19.9% had low self-esteem, and 34.6% had social media addiction. There was a significant relationship between narcissism and social media addiction (p=0.021) and between self-esteem and social media addiction (p=0.002).Conclusion: There is a relationship between narcissism, self-esteem, and social media addiction in university students. This indicates the importance of preliminary psychological screening in students, especially regarding self-esteem, narcissism, and social media addiction, to develop approaches that will ensure good academic achievements and physical health among students.
背景:自恋是一种人们不断要求被赞美和优先考虑的状态。自尊是对一个人价值的主观评价。有几项研究将自恋和自卑与社交媒体成瘾的风险因素联系起来。社交媒体成瘾是一种疾病,个人表现出一种不健康的冲动,即访问社交媒体,直到它扰乱了其他活动。本研究旨在探讨医学生自恋、自尊与社交媒体成瘾之间的关系。方法:本研究采用横断面观察分析方法,对印度尼西亚阿特玛查亚天主教大学211名临床前医学专业学生进行研究。本研究采用自恋人格量表(NPI-16)、Rosenberg自尊量表(RSES)和Bergen社交媒体成瘾量表(BSMAS)。数据采用STATA分析程序中的卡方进行统计学分析。结果:自恋者占6.6%,自卑者占19.9%,社交媒体成瘾者占34.6%。自恋与社交媒体成瘾(p=0.021)、自尊与社交媒体成瘾(p=0.002)存在显著相关。结论:大学生自恋、自尊与社交媒体成瘾之间存在一定的关系。这表明了对学生进行初步心理筛查的重要性,特别是在自尊、自恋和社交媒体成瘾方面,以制定确保学生取得良好学业成绩和身体健康的方法。
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引用次数: 2
Effect of Health Education Video on Knowledge about among Women in Childbearing Age 健康教育视频对育龄妇女健康知识的影响
Pub Date : 2021-03-31 DOI: 10.15850/AMJ.V8N1.2150
Annisa Nuraini, Puspa Sari, S. Astuti, Lani Gumilang, Didah Didah
Background: Toddlers aged 24-59 months are experiencing a very rapid growth process; however, they are also prone to have nutritional problems, including stunting. Stunting occurs mainly within the first 2 to 5 years of life. The main cause is a lack of knowledge on toddler’s nutritional intake among women of childbearing age. This study aimed to explore the effect of health education using video media on the knowledge about stunting among women of childbearing age.Methods: This was a quantitative, experimental study with one group pretest-posttest design conducted in July-November 2019 on women of childbearing age in the working area of Public Health Center (Pusat Kesehatan Masyarakat, Puskesmas) Jatinangor, West Java, Indonesia. Respondents were recruited using the Multistage Random Sampling according to the inclusion criteria. A pre-test was administered before the health education session on stunting and a post-test was administered afterwards. Data collected were then analyzed using the Wilcoxon Test.Results: In total, 211 women were included. Education video on stunting was proved to significantly increase the respondent's knowledge on stunting (p=0.000, r value=0.690).Conclusion: Health education video clearly increases knowledge on stunting among women of childbearing age. Thus, video medium can be used as a preferred method for disseminating knowledge on various health topics.
背景:24-59个月的幼儿正在经历一个非常快速的成长过程;然而,他们也容易出现营养问题,包括发育迟缓。发育迟缓主要发生在生命的头2至5年。主要原因是育龄妇女缺乏对幼儿营养摄入的认识。本研究旨在探讨视讯媒体健康教育对育龄妇女发育迟缓知识的影响。方法:这是一项定量的实验研究,采用一组前测后测设计,于2019年7月至11月对印度尼西亚西爪哇省贾提南果市公共卫生中心(Pusat Kesehatan Masyarakat, Puskesmas)工作区域的育龄妇女进行了一项研究。根据纳入标准,采用多阶段随机抽样方法招募受访者。在关于发育迟缓的健康教育课程之前进行了一次预测试,之后进行了一次后测试。然后使用Wilcoxon检验分析收集的数据。结果:共纳入211名妇女。发育不良教育视频被证明能显著提高被调查者对发育不良的认识(p=0.000, r值=0.690)。结论:健康教育视频能明显提高育龄妇女对发育迟缓的认识。因此,视频媒介可以作为传播关于各种健康主题的知识的首选方法。
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引用次数: 0
Clinical Characteristics of Pediatric with Germ Cell Tumor: Experience in a Developing Country 发展中国家儿童生殖细胞肿瘤的临床特点
Pub Date : 2021-03-31 DOI: 10.15850/AMJ.V8N1.1876
L. Reniarti, Anisah Febri, N. M. Sari
Background: Germ cell tumor (GCT) occurs in 3% of pregnancy malignancies and increases by 15% during adolescence. In developing countries, the five-year survival rate is 98% and 80% for GCT earlier stage and malignant tumor, respectively. This study aimed to gather information about clinical manifestations of GCT and to evaluate the treatment outcome in pediatric GCT patients at Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaMethods: A descriptive cross-sectional study design with a total sampling method was conducted using secondary data from the medical record of pediatric patients diagnosed with GCT from 2015 to 2018. Data on nutritional status, clinical characteristics, histopathology stage, hematological profiles, chemical markers, treatment methods, completeness of treatment, and outcome at the end of treatment were collected and presented using tables and charts.Results: Of the 44 subjects, girls (77.3%) were predominant, with a mean age of 2 years old and normal nutritional status (59.1%). Patients generally had abdominal mass (97.7%) and most had intragonadal GCT (95.5%), with ovarium (76.2%) as the most common location. The most frequent GCT histopathology was yolk sac tumor (34.1%), with an Alpha-fetoprotein (AFP) level of >100.000 (6.8%). Almost all patients (97.7%) had undergone surgery; however, 47% of patients did not complete their treatment. At the end of treatment, the majority of patients survived (86.4%).Conclusion: Germ cell tumor has various clinical characteristics. Understanding these characteristics will enable clinicians to make a proper diagnosis and provide immediate management that will lead to a better prognosis.
背景:生殖细胞肿瘤(GCT)发生在3%的妊娠期恶性肿瘤中,在青春期增加15%。在发展中国家,GCT早期和恶性肿瘤的五年生存率分别为98%和80%。本研究旨在收集有关GCT临床表现的信息,并评估印度尼西亚万隆Hasan Sadikin综合医院儿童GCT患者的治疗结果。收集营养状况、临床特征、组织病理学分期、血液学特征、化学标志物、治疗方法、治疗完整性和治疗结束时的结果等数据,并使用表格和图表进行展示。结果:在44例受试者中,女孩(77.3%)占主导地位,平均年龄2岁,营养状况正常(59.1%)。患者通常有腹部肿块(97.7%),大多数有胃内GCT(95.5%),最常见的部位是卵巢(76.2%)。最常见的GCT组织病理学是卵黄囊肿瘤(34.1%),甲胎蛋白(AFP)水平>10.00万(6.8%)。几乎所有患者(97.7%)都接受过手术;然而,47%的患者没有完成治疗。在治疗结束时,大多数患者(86.4%)存活下来。结论:生殖细胞肿瘤具有多种临床特征。了解这些特征将使临床医生能够做出正确的诊断,并提供即时管理,从而获得更好的预后。
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引用次数: 0
Anti-migration Effect of Aaptos suberitoides Fraction in HCT-116 Colorectal Cancer Cell Line 木犀草素组分在大肠癌细胞株HCT-116中的抗迁移作用
Pub Date : 2021-03-31 DOI: 10.15850/AMJ.V8N1.2231
Dany Muhammad Daffa, M. H. Bashari, E. Ariyanto, Tenny Putri, N. Qomarilla
Background: Colorectal cancer is the second leading cause of mortality and the most prevalent cancer worldwide. Most patients, who come with late-stage, have ineffective treatments and some side effects in chemotherapy. Aaptos suberitoides has potential anti-cancer effects due to its bioactive compounds such as aptamine. This study aimed to evaluate the migration inhibition effect of Aaptos suberitoides fraction in HCT-116 cell line.Methods: This study was an experimental study. Aaptos suberitoides specimen was taken in Tinjil Island and fractionated with ethyl acetate. HCT-116 cell line was added with Aaptos suberitoides fraction and cellular migration activity was observed in 48 hours of which the scratch assay was performed. The gap closure area was determined with ImageJ software.Results: The data showed that a low concentration of Aaptos suberitoides fraction inhibited migration activity in HCT-116 cell line as follow; 1 and 5 mg/L Aaptos suberitoides fraction inhibit 3-4 % cancer cell migration in 24 hours, and 10-11% inhibition in 48 hours, respectively. However, 10 mg/L fraction concentration only inhibited 7-14% of the migration effect.Conclusion: Aaptos suberitoides fraction suggests insignificant migration inhibition in colorectal cancer cells and only inhibits less than 15 % HCT-116 cell line.
背景:癌症是全球第二大致死原因,也是最常见的癌症。大多数晚期患者在化疗中治疗无效,并有一些副作用。木犀草素具有潜在的抗癌作用,因为它含有适体胺等生物活性化合物。本研究旨在评价木犀草素组分对HCT-116细胞迁移的抑制作用。方法:本研究为实验研究。木犀标本取自廷吉尔岛,用乙酸乙酯分馏。向HCT-116细胞系中加入木犀草素组分,并在48小时内观察到细胞迁移活性,其中进行划痕测定。间隙闭合面积用ImageJ软件确定。结果:低浓度的木犀草素组分对HCT-116细胞迁移活性的抑制作用如下;1和5mg/L的Aaptos suberitoides组分分别在24小时内抑制3-4%的癌症细胞迁移,在48小时内抑制10-11%。但10mg/L组分浓度仅能抑制7-14%的迁移效应。结论:木犀草素组分对结直肠癌癌症细胞的迁移抑制作用不明显,仅对小于15%的HCT-116细胞株有抑制作用。
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引用次数: 0
Profile of Osteomyelitis Patients Visiting the Orthopedic Clinic of Dr. Hasan Sadikin General Hospital, Indonesia, in 2017–2018 2017-2018年访问印度尼西亚Hasan Sadikin医生综合医院骨科诊所的骨脊髓炎患者简介
Pub Date : 2021-03-31 DOI: 10.15850/AMJ.V8N1.2075
A. Nugraha, H. N. Rasyid, H. Sukandar
Background: Osteomyelitis is an inflammatory process caused by microorganism infection that leads to bone destruction. Osteomyelitis may affect all bones, particularly long bones, and infects all ages. This disease is hard to diagnose and the treatment is complex due to the disease’s heterogenicity, pathophysiology, clinical presentation, and management. This study aimed to determine the profile of osteomyelitis inpatients and outpatients presented to the Orthopedic Clinic of Dr. Hasan Sadikin General Hospital Bandung, IndonesiaMethods: This was a descriptive cross-sectional study conducted from July to October 2019 using the total sampling method. Data were collected from the medical records of osteomyelitis inpatients and outpatients presented to the Orthopedic Clinic of Dr. Hasan Sadikin General Hospital Bandung, Indonesia from 2017–2018. Data were then analyzed descriptively and the results were presented in frequencies.Result: In total, 90 data were retrieved. Most of data presented male patients (n= 69, 76.7%) with the age range of 20–29 years old (24.4%). The majority of these patients experienced chronic onset of disease (94.4%) located on the tibia (51.1%), which was caused by a post-operative procedure (61.1%). The most common treatment was operative procedure without antibiotic beads (51.1%). Staphylococcus aureus was the common pathogens identified in these patients (22.2%).Conclusion: The majority of osteomyelitis patients are males in productive age with chronic onset of disease located on the tibia caused by a post-operative procedure. Staphylococcus aureus is the common pathogen involved and the most common treatment is an operative procedure without antibiotic beads.
背景:骨髓炎是一种由微生物感染引起的炎症过程,可导致骨骼破坏。骨髓炎可能影响所有骨骼,尤其是长骨,并感染所有年龄段的人。由于疾病的异质性、病理生理学、临床表现和管理,这种疾病很难诊断,治疗也很复杂。本研究旨在确定印度尼西亚万隆Hasan Sadikin综合医院骨科门诊的骨髓炎住院患者和门诊患者的情况。方法:这是一项描述性横断面研究,于2019年7月至10月使用总抽样法进行。数据收集自2017年至2018年印尼万隆Hasan Sadikin综合医院骨科门诊的骨髓炎住院患者和门诊患者的医疗记录。然后对数据进行描述性分析,结果以频率表示。结果:总共检索到90个数据。大多数数据显示男性患者(n=69,76.7%),年龄范围为20-29岁(24.4%)。这些患者中大多数经历了位于胫骨的慢性疾病发作(94.4%)(51.1%),由术后手术引起的骨髓炎(61.1%)。最常见的治疗方法是不使用抗生素珠的手术(51.1%)。金黄色葡萄球菌是这些患者中发现的常见病原体(22.2%)。结论:大多数骨髓炎患者是育龄男性,因术后手术导致胫骨慢性起病。金黄色葡萄球菌是常见的病原体,最常见的治疗方法是在没有抗生素珠的情况下进行手术。
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引用次数: 2
Risk Factors of Dementia in Elderly of Bandung City, Indonesia: A Community-Dwelling Study 印尼万隆市老年人痴呆危险因素的社区居住研究
Pub Date : 2020-12-31 DOI: 10.15850/amj.v7n4.2150
Sarah Fitri Janaris, Sharon Gondodiputro, N. Arisanti
Background: Multiple organ degenerative processes are parts of a normal biological process in aging. One of the geriatric syndromes is cognitive disorders that range from a mild cognitive impairment to dementia. The aim of this study was to analyze factors contributing to the occurrence of dementia in the elderly. Methods: A cross-sectional analytical study was conducted using secondary data on 306 elderly people who visited the Integrated Health Post ( Pos Pembinaan Terpadu , Posbindu ) from June to August 2016 in Bandung City, Indonesia. Nine variables were included in this study: age, gender, education level, marital status, occupation, living arrangements, social participation, comorbidity, and dementia. The dementia status was measured by the Mini-Mental State Examination and Mini Cog Assessment instruments. Data were then analyzed statistically using Chi-Square, Fisher Exact, and Kolmogorov-Smirnov tests, as well as using the multivariate logistic regression. Results: Around 35.3% (95%CI=30%–40.6%) of respondents had dementia. There were relationships between dementia and age (p=0.035), level of education (p=0.000), and social participation (p=0.001). Social participation was the most dominant risk factor of dementia (OR=2.703;95%CI=1.491-4.902). Conclusions: Age, education level, and social participation are risk factors that contribute to dementia. The elderly who has less than two times per week of social participation has a 2.7 times higher risk for having dementia compared to the elderly who has more than two times per week of social participation.
背景:多器官退化过程是衰老过程中正常生物过程的一部分。老年综合征之一是从轻度认知障碍到痴呆的认知障碍。本研究的目的是分析导致老年痴呆症发生的因素。方法:使用二级数据对2016年6月至8月在印度尼西亚万隆市访问综合卫生站(Pos Pembinan Terpadu,Posbindu)的306名老年人进行横断面分析研究。本研究包括九个变量:年龄、性别、教育水平、婚姻状况、职业、生活安排、社会参与、共病和痴呆。通过迷你精神状态检查和迷你Cog评估工具测量痴呆状态。然后使用卡方检验、Fisher Exact检验和Kolmogorov-Smirnov检验以及多变量逻辑回归对数据进行统计分析。结果:约35.3%(95%CI=30%-40.6%)的受访者患有痴呆症。痴呆与年龄(p=0.035)、教育水平(p=0.000)和社会参与(p=0.001)之间存在关系。社会参与是痴呆的最主要危险因素(OR=2.703;95%CI=1.491-4.902)。结论:年龄、教育水平和社会参与是导致痴呆的危险因素。与每周参加两次以上社会活动的老年人相比,每周参加不到两次的老年人患痴呆症的风险高2.7倍。
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引用次数: 1
Relationship between Nomophobia and Attention among Medical Students in Jakarta 雅加达医科学生的Nomophobia与注意力的关系
Pub Date : 2020-12-31 DOI: 10.15850/amj.v7n4.2033
Kevin Tanoto, Eva Suryani, Satya Joewana
Background : The advancements in technology in the form of smartphones have made life easier; however, some negative effects have been recorded with regards to the use of smartphone. Among these negative effects are nomophobia, or a phobia of no mobile phone, and lack of attention. This study explored the relationship between nomophobia and attention in medical students. Methods : This was a cross-sectional analytic study on medical students in Jakarta in 2019. The Nomophobia Questionnaire (NMP-Q) was used to measure the level of nomophobia and the Six Letter Cancellation Test (SLCT) was used to measure attention. Data collected were analyzed using a simple linear regression test. Result: There was a weak negative relationship between the severity of nomophobia and attention (r=.161). However, nomophobia score was a very weak predictor for attention with an adjusted r-squared score of .021. Conclusions: Nomophobia does not necessarily affect the attention of medical students. Excessive mobile phone use does cause nomophobia and lack of attention. Therefore, smartphones need to be used wisely.
背景:智能手机形式的技术进步使生活更容易;然而,智能手机的使用也带来了一些负面影响。这些负面影响包括无手机恐惧症(nomophobia)和缺乏注意力。本研究探讨医学生无物恐惧症与注意力的关系。方法:对2019年雅加达医科学生进行横断面分析研究。无恐惧症问卷(NMP-Q)用于测量无恐惧症的水平,六字母消除测试(SLCT)用于测量注意力。收集的数据使用简单的线性回归检验进行分析。结果:无物恐惧症的严重程度与注意力呈弱负相关(r= 0.161)。然而,无恐惧症分数是一个非常弱的预测注意力的指标,调整后的r平方分数为0.021。结论:无恐惧症并不一定影响医学生的注意力。过度使用手机确实会导致无手机恐惧症和注意力不集中。因此,智能手机需要明智地使用。
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引用次数: 1
Transfusion Reactions in Pediatric Cancer Patients 儿童癌症患者的输血反应
Pub Date : 2020-12-31 DOI: 10.15850/amj.v7n4.1820
Cakra Jati Pranata, Nur Suryawan, D. Prihatni
Background:  Transfusion is an essential component of supportive management for cancer patients with anemia and thrombocytopenia. It is generally safe; however, it has several risks and complications including those caused by transfusion reactions. This study aimed to describe transfusion reactions in pediatric cancer patients in a tertiary hospital in Indonesia. Methods: This was a descriptive cross-sectional study with a total sampling method. A prospective analysis was performed on episodes of blood transfusion in pediatric patients aged younger than 18 years old with cancer and were hospitalized at the Department of Child Health of the hospital from July to August 2019. After the consent of the parents, the patients were interviewed for various transfusion reactions. Data collected were presented using tables and charts. Results: Leukemia was the most frequent cancer in children cancer patients who need transfusion. Out of 42 children included, 155 episodes of transfusion were observed with 22 episodes showed transfusion reactions (14.2%). The most frequent manifestations were pruritus (31.8%), followed by combination of pruritus and erythema (27.4%) and fever (13.6%). These reactions appeared mostly in 1 to 2 hours (27.2%), with most were mild reactions (59.1%). Conclusion: Transfusion reactions mostly occurred among pediatric patients with cancer in the acute phase with clinical manifestation of allergic reactions, predominantly mild. Early identification of these reactions would result in better treatment and prevention for recurrence of transfusion reactions.
背景:输血是癌症贫血和血小板减少症患者支持性管理的重要组成部分。它通常是安全的;然而,它有一些风险和并发症,包括由输血反应引起的风险和并发症。本研究旨在描述印度尼西亚一家三级医院癌症儿科患者的输血反应。方法:这是一项描述性横断面研究,采用全面抽样法。对2019年7月至8月在医院儿童卫生部住院的癌症18岁以下儿科患者的输血事件进行了前瞻性分析。在父母同意后,对患者进行各种输血反应的访谈。收集到的数据用表格和图表表示。结果:白血病是需要输血的儿童癌症患者中最常见的癌症。在包括在内的42名儿童中,观察到155次输血,其中22次出现输血反应(14.2%)。最常见的表现是瘙痒(31.8%),其次是瘙痒和红斑(27.4%)以及发烧(13.6%)。这些反应主要出现在1至2小时内(27.2%),结论:癌症患儿急性期输血反应多,临床表现为过敏反应,以轻度为主。尽早发现这些反应将有助于更好地治疗和预防输血反应的复发。
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引用次数: 0
Differences in Bleeding Episodes in Severe Hemophilia A Based on Nutritional Status 基于营养状况的严重血友病A出血发作的差异
Pub Date : 2020-12-31 DOI: 10.15850/amj.v7n4.1938
Wenny Simamora, Susi Susanah, A. Oehadian
Background: Hemophilia A is a congenital bleeding disorder caused by the deficiency of coagulation factor VIII and is characterized by joint bleeding, especially in weight-bearing joints. An excess weight may cause bleeding in hemophilia due to increased joint tension. This study aimed to determine the differences in bleeding episodes between severe hemophilia A patients with and without excess weight. Method: A comparative observational analytic study was conducted in March-November 2019 using a cross-sectional design. Subjects were patients with severe hemophilia A registered in the Indonesian Hemophilia Society Association in West Java and had had severe hemophilia A for at least two years old with complete data on date of birth, height, weight, and bleeding intensity. Subjects were divided into groups with excess weight (excess weight) and without excess weight (non-excess weight). Nutritional status in adults was determined based on age-specific percentile BMI. Bleeding episodes were determined as frequency of bleeding in one year. The Mann-Whitney statistical test was used to observe the difference between groups. Result: Of 226 severe hemophilia A patients registered, only 155 patients were included. Of these, 121 patients did not have excess weight and 34 had excess weight. The median bleeding episodes of in the non-excess weight and excess weight groups were 24(1-48) and 24(8-48), respectively (p=0.761). Conclusion: There is no difference in bleeding episodes Between severe hemophilia A patients with excess weight and without excess weight. However, good nutrition education needs to be provided to these patients since excess weight may increase bleeding in joints.
背景:血友病A是一种由凝血因子VIII缺乏引起的先天性出血性疾病,其特征是关节出血,尤其是负重关节出血。由于关节张力增加,超重可能会导致血友病出血。本研究旨在确定有和没有超重的严重血友病A患者出血事件的差异。方法:2019年3月至11月,采用横断面设计进行了一项比较观察性分析研究。受试者是在西爪哇印尼血友病协会注册的严重血友病A患者,患有严重血友病A至少两年,出生日期、身高、体重和出血强度数据完整。受试者被分为超重组(超重)和非超重组(非超重)。成年人的营养状况是根据特定年龄的百分位BMI来确定的。出血事件被确定为一年内出血的频率。使用Mann-Whitney统计检验来观察各组之间的差异。结果:在登记的226例严重血友病A患者中,只有155例被纳入。其中,121名患者没有超重,34名患者超重。非超重组和超重组的中位出血次数分别为24(1-48)和24(8-48)(p=0.761)。然而,需要为这些患者提供良好的营养教育,因为超重可能会增加关节出血。
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引用次数: 0
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