KI-67 is a marker for cell proliferation which binds a nuclear antigen and is thus a prime antibody in immunohistochemistry. Scoring methodologies derived from KI-67 immunostaining have shown promise as predictors of lethality in a range of cancers [1]. The most common scoring method is the labelling index, a ratio of KI-67 positive cells to the entire population [1]. Manual calculation of a labelling index can be a time-consuming process for pathologists, who count cells in a bright field. Automated scoring algorithms and programs have been written to generate labelling indices, but they are nonspecific with respect to cell type and most often skew results by including stromal cells in the index. This problem is particularly relevant in breast cancer, where tumors are often located in a field of fibroadipose tissue. We have adapted algorithms for immunostain scoring and tested 2 stromal cell filtration algorithms which remove these cells based on their elongated nuclear morphology.
{"title":"Stromal Filters in Automated Immunostain Scoring","authors":"Kunal Patel, A. Bui, G. Riedlinger, Y. Yagi","doi":"10.1155/2014/497426","DOIUrl":"https://doi.org/10.1155/2014/497426","url":null,"abstract":"KI-67 is a marker for cell proliferation which binds a nuclear antigen and is thus a prime antibody in immunohistochemistry. Scoring methodologies derived from KI-67 immunostaining have shown promise as predictors of lethality in a range of cancers [1]. The most common scoring method is the labelling index, a ratio of KI-67 positive cells to the entire population [1]. \u0000 \u0000Manual calculation of a labelling index can be a time-consuming process for pathologists, who count cells in a bright field. Automated scoring algorithms and programs have been written to generate labelling indices, but they are nonspecific with respect to cell type and most often skew results by including stromal cells in the index. This problem is particularly relevant in breast cancer, where tumors are often located in a field of fibroadipose tissue. We have adapted algorithms for immunostain scoring and tested 2 stromal cell filtration algorithms which remove these cells based on their elongated nuclear morphology.","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121397468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
There is currently a major disconnection in the publishing universe not only for retention, transmission, and analysis of digital images in pathology but also for new and emerging computationally intensive imaging methodologies. Many authors gravitate towards engineering journals, which are not usually read by pathologists or, for that matter, most biomedical investigators. The pathobiological application shown is often a proof-of-concept rather than a sophisticated investigative study. Papers that appear in pathology journals have the opposite problem; they are sketchy about the physical/engineering side of the work and do not attract many readers from the engineering and physics community. Nature methods partially bridge this gap, but it is more about the technology than the application of this technology for novel scientific discovery. For this reason, there is a need for a journal that can attract both kinds of authors (and readers) and serve as an integrative focus for work in these fields. Our evolving work towards this goal will be discussed.
{"title":"An Editors Perspective on Digital Pathology","authors":"Stanley Cohen","doi":"10.1155/2014/565437","DOIUrl":"https://doi.org/10.1155/2014/565437","url":null,"abstract":"There is currently a major disconnection in the publishing universe not only for retention, transmission, and analysis of digital images in pathology but also for new and emerging computationally intensive imaging methodologies. Many authors gravitate towards engineering journals, which are not usually read by pathologists or, for that matter, most biomedical investigators. The pathobiological application shown is often a proof-of-concept rather than a sophisticated investigative study. Papers that appear in pathology journals have the opposite problem; they are sketchy about the physical/engineering side of the work and do not attract many readers from the engineering and physics community. Nature methods partially bridge this gap, but it is more about the technology than the application of this technology for novel scientific discovery. For this reason, there is a need for a journal that can attract both kinds of authors (and readers) and serve as an integrative focus for work in these fields. Our evolving work towards this goal will be discussed.","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123044486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Scalable Adaptive Graphics Environment (SAGE) was developed at theUniversity of Illinois at Chicago’s (UIC) Electronic Visualization Laboratory (EVL) to facilitate collaborative efforts that require the sharing of data-intensive information for analysis. SAGE is a cross-platform, communitydriven, open-source visualization and collaboration tool that enables users to access, display, and share a variety of dataintensive information, in a variety of resolutions and format, frommultiple sources, on tiled display walls of arbitrary size. SAGE walls have had the ability to display digital-cinema animations, high resolution images, high-definition videoconferences, presentation slides, documents, spreadsheets, and computer screens; however, there was no way to display and manipulate histologic whole-slide images (WSIs). Our desire was to create a tool to permit the importation, display, and manipulation of WSI in the SAGE environment.
{"title":"Scalable Adaptive Graphics Environment: A Novel Way to View and Manipulate Whole-Slide Images","authors":"V. Mateevitsi, B. Levy","doi":"10.1155/2014/517953","DOIUrl":"https://doi.org/10.1155/2014/517953","url":null,"abstract":"The Scalable Adaptive Graphics Environment (SAGE) was developed at theUniversity of Illinois at Chicago’s (UIC) Electronic Visualization Laboratory (EVL) to facilitate collaborative efforts that require the sharing of data-intensive information for analysis. SAGE is a cross-platform, communitydriven, open-source visualization and collaboration tool that enables users to access, display, and share a variety of dataintensive information, in a variety of resolutions and format, frommultiple sources, on tiled display walls of arbitrary size. SAGE walls have had the ability to display digital-cinema animations, high resolution images, high-definition videoconferences, presentation slides, documents, spreadsheets, and computer screens; however, there was no way to display and manipulate histologic whole-slide images (WSIs). Our desire was to create a tool to permit the importation, display, and manipulation of WSI in the SAGE environment.","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129447952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Griffin, P. Anand, R. Tang, A. Zambeli-Ljepović, M. Senter-Zapata, M. Lewin-Berlin, A. Bui, J. Singh, K. Patel, W. Sarraj, J. Gilbertson, Y. Yagi, D. Kopans, R. Moore, A. Ly, M. Saksena, G. Nielsen, G. Harris, N. Gershenfeld, B. Smith, J. Michaelson
The absence of real-time, detailed, 3D information on the composition of surgical specimens presents an enormous challenge in surgical oncology and pathology.
缺乏手术标本组成的实时、详细的3D信息，对外科肿瘤学和病理学提出了巨大的挑战。
{"title":"The Role of Micro CT in the Imaging of Cancer","authors":"M. Griffin, P. Anand, R. Tang, A. Zambeli-Ljepović, M. Senter-Zapata, M. Lewin-Berlin, A. Bui, J. Singh, K. Patel, W. Sarraj, J. Gilbertson, Y. Yagi, D. Kopans, R. Moore, A. Ly, M. Saksena, G. Nielsen, G. Harris, N. Gershenfeld, B. Smith, J. Michaelson","doi":"10.1155/2014/608206","DOIUrl":"https://doi.org/10.1155/2014/608206","url":null,"abstract":"The absence of real-time, detailed, 3D information on the composition of surgical specimens presents an enormous challenge in surgical oncology and pathology.","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130354753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Besusparis, S. Jokubauskiene, B. Plancoulaine, P. Herlin, A. Laurinavičienė, A. Buivydienė, A. Laurinavičius
1Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, 21 M. K. Ciurlionio Street, LT-03101 Vilnius, Lithuania 2Université de Caen, Esplanade de la Paix, 14032 Caen, France 3Centre of Hepatology, Gastroenterology and Dietetics, Vilnius University Hospital Santariskiu Clinics, 2 Santariskiu Street, LT-08661 Vilnius, Lithuania 4Clinic of Gastroenterology, Nephrourology and Surgery, Medical Faculty, Vilnius University, 2 Santariskiu Street, LT-08661 Vilnius, Lithuania
1Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, 21 M. K.Ciurlionio Street, LT-03101 Vilnius, Lithuania 2Université de Caen, Esplanade de la Paix, 14032 Caen, France 3Centre of Hepatology, Gastroenterology and Dietetics, Vilnius University Hospital Santariskiu Clinics, 2 Santariskiu Street, LT-08661 Vilnius, Lithuania 4Clinic of Gastroenterology, Nephrourology and Surgery, Medical Faculty, Vilnius University, 2 Santariskiu Street, LT-08661 Vilnius, Lithuania
{"title":"Quantification Accuracy of Liver Fibrosis by In Vivo Elastography and Digital Image Analysis of Liver Biopsy Histochemistry","authors":"J. Besusparis, S. Jokubauskiene, B. Plancoulaine, P. Herlin, A. Laurinavičienė, A. Buivydienė, A. Laurinavičius","doi":"10.1155/2014/317635","DOIUrl":"https://doi.org/10.1155/2014/317635","url":null,"abstract":"1Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, 21 M. K. Ciurlionio Street, LT-03101 Vilnius, Lithuania 2Université de Caen, Esplanade de la Paix, 14032 Caen, France 3Centre of Hepatology, Gastroenterology and Dietetics, Vilnius University Hospital Santariskiu Clinics, 2 Santariskiu Street, LT-08661 Vilnius, Lithuania 4Clinic of Gastroenterology, Nephrourology and Surgery, Medical Faculty, Vilnius University, 2 Santariskiu Street, LT-08661 Vilnius, Lithuania","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128317478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The emerging field of digital pathology has many applications including the ability to easily and quickly consult with colleagues at a distance.
数字病理学这一新兴领域有许多应用，包括能够轻松快速地与远程同事进行咨询。
{"title":"Digital Teleconsultation: Clinical Perspectives","authors":"D. Wilbur","doi":"10.1155/2014/460989","DOIUrl":"https://doi.org/10.1155/2014/460989","url":null,"abstract":"The emerging field of digital pathology has many applications including the ability to easily and quickly consult with colleagues at a distance.","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130855663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Kayser, S. Borkenfeld, A. Djenouni, Joachim Christian Manning, H. Kaltner, G. Kayser, H. Gabius
Basically, TBD investigates the function and structures of biological meaningful individual units, such as macromolecules, genes, nuclei, cells, vessels, and organs. All functions are bound to structures that ensure reliable and effective information and energy exchange. Disturbance of structures induces less effective or complete loss of functions. The complex interactions at molecular biological level (macromolecules) and their continuous reproduction require extensive computations in addition to the sophisticated biochemical analysis systems. Nearly all assessable information is of visual nature or can be visualized. Thus, image content analysis applied in a sophisticated manner might be one key procedure to assist human image interpretation or to even replace it. Image content information includes information that can be derived from predefined functional units (objects), their spatial arrangement (structure), pixel derived features prior of after image transformations (texture), and syntactic compositions of objects or of pixel based primitives (syntactic structure analysis). Statistically significant clusters can represent either new biological significant units (e.g., tubular arrangement of specific (endothelial) cells forming a vessel, spatial composition of cells of different nature (cellular sociology) forming a bronchus with assumed participation of endogenous lectins [1]) or other new items such as entropy flow charts and diffusion densities. All these parameters form a powerful set of image information features. They can be considered to be independent from each other and calculated independently for their specific clinical significance (disease association).
{"title":"Digital Pathology: How Far Are We from Automated Tissue-Based Diagnosis?","authors":"K. Kayser, S. Borkenfeld, A. Djenouni, Joachim Christian Manning, H. Kaltner, G. Kayser, H. Gabius","doi":"10.1155/2014/458954","DOIUrl":"https://doi.org/10.1155/2014/458954","url":null,"abstract":"Basically, TBD investigates the function and structures of biological meaningful individual units, such as macromolecules, genes, nuclei, cells, vessels, and organs. All functions are bound to structures that ensure reliable and effective information and energy exchange. Disturbance of structures induces less effective or complete loss of functions. The complex interactions at molecular biological level (macromolecules) and their continuous reproduction require extensive computations in addition to the sophisticated biochemical analysis systems. Nearly all assessable information is of visual nature or can be visualized. Thus, image content analysis applied in a sophisticated manner might be one key procedure to assist human image interpretation or to even replace it. Image content information includes information that can be derived from predefined functional units (objects), their spatial arrangement (structure), pixel derived features prior of after image transformations (texture), and syntactic compositions of objects or of pixel based primitives (syntactic structure analysis). Statistically significant clusters can represent either new biological significant units (e.g., tubular arrangement of specific (endothelial) cells forming a vessel, spatial composition of cells of different nature (cellular sociology) forming a bronchus with assumed participation of endogenous lectins [1]) or other new items such as entropy flow charts and diffusion densities. All these parameters form a powerful set of image information features. They can be considered to be independent from each other and calculated independently for their specific clinical significance (disease association).","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"372 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120931775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Taniyama, K. Kuraoka, A. Saito, Miho Tanaka, Yoko Kodama, J. Sakane, Yukari Nakagawa, Naoko Yasumura, T. Nishimura, K. Taniyama
Diagnosis. A VS800 (OLYMPUS, Tokyo, Japan) in a WSI system and an AS-400 (KURABO, Tokyo, Japan) for the ASP systemwere used. Up to 100 slides consisting of biopsy, endoscopic mucosal resection (EMR), or endoscopic submucosal dissection (ESD) specimenswere scanned and stored digitally in one set and the digital images were viewed on a monitor in a separate room using a VS800 viewer. Ocular observation using a conventional microscope was used when necessary to look at the specimens directly. One hundred sixty-six biopsy specimens were analyzed to evaluate the basic ability of the current WSI system in making a pathological diagnosis.
诊断在WSI系统中使用VS800 (OLYMPUS, Tokyo, Japan)，在ASP系统中使用AS-400 (KURABO, Tokyo, Japan)。由活检、内镜粘膜切除(EMR)或内镜粘膜下剥离(ESD)标本组成的多达100张载玻片被扫描并数字化存储在一组中，并使用VS800查看器在单独房间的监视器上查看数字图像。必要时使用常规显微镜进行眼部观察，直接观察标本。对166例活检标本进行分析，以评估当前WSI系统进行病理诊断的基本能力。
{"title":"Pathological Diagnosis with a Whole Slide Imaging System","authors":"D. Taniyama, K. Kuraoka, A. Saito, Miho Tanaka, Yoko Kodama, J. Sakane, Yukari Nakagawa, Naoko Yasumura, T. Nishimura, K. Taniyama","doi":"10.1155/2014/690804","DOIUrl":"https://doi.org/10.1155/2014/690804","url":null,"abstract":"Diagnosis. A VS800 (OLYMPUS, Tokyo, Japan) in a WSI system and an AS-400 (KURABO, Tokyo, Japan) for the ASP systemwere used. Up to 100 slides consisting of biopsy, endoscopic mucosal resection (EMR), or endoscopic submucosal dissection (ESD) specimenswere scanned and stored digitally in one set and the digital images were viewed on a monitor in a separate room using a VS800 viewer. Ocular observation using a conventional microscope was used when necessary to look at the specimens directly. One hundred sixty-six biopsy specimens were analyzed to evaluate the basic ability of the current WSI system in making a pathological diagnosis.","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126740968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maulana Abdul Aziz, H. Kanazawa, Y. Murakami, Fumikazu Kimura, Masahiro Yamaguchi, T. Kiyuna, Yoshiko Yamashita, A. Saito, M. Ishikawa, Naoki Kobayashi, T. Abe, A. Hashiguchi, M. Sakamoto
{"title":"Enhancing Automatic Classification of Hepatocellular Carcinoma Images through Image Masking, Tissue Changes, and Trabecular Features","authors":"Maulana Abdul Aziz, H. Kanazawa, Y. Murakami, Fumikazu Kimura, Masahiro Yamaguchi, T. Kiyuna, Yoshiko Yamashita, A. Saito, M. Ishikawa, Naoki Kobayashi, T. Abe, A. Hashiguchi, M. Sakamoto","doi":"10.1155/2014/726782","DOIUrl":"https://doi.org/10.1155/2014/726782","url":null,"abstract":"","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129777246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Validation of whole slide imaging (WSI) is an important process for clinical practice. From a vendor perspective, validation seeks to achieve premarket approval from a regulatory agency in order for them to sell their WSI devices for an intended use (e.g., primary diagnosis). Academic validations are different, as these research studies typically result in publications reporting results of a self-defined, focused validation and their findings may not be generalizable. In general, published validation studies show good concordance for diagnoses made by WSI compared to glass slides. Clinical validation in the laboratory involves documenting the process and results of a validation study for an intended clinical use. This is typically conducted in accordance with available recommendations and/or guidelines. Validation studies comparing WSI (digital slides) to glass sides (traditional light microscopy) customarily measure concordance (agreement) between these two modalities. However, this outcome measurement can be influenced by several factors including validation study design, technology used, user training, observer variability, and case difficulty. Interobserver variability is likely to be greater than intraobserver variability, as not all pathologists may agree on certain diagnoses. Several guidelines have been developed that address WSI validation, which includes the College of American Pathologists (CAP) recommendations developed for validating WSI for diagnostic purposes. These CAP recommendations were subsequently adopted by the American Telemedicine Association (ATA) clinical guidelines for telepathology. Practical guidelines that assist pathology laboratories seeking to validate their own WSI systems for diagnostic work not only are timely but also help promote digital pathology adoption.
{"title":"Validation of Whole Slide Imaging in Pathology","authors":"L. Pantanowitz","doi":"10.1155/2014/476854","DOIUrl":"https://doi.org/10.1155/2014/476854","url":null,"abstract":"Validation of whole slide imaging (WSI) is an important process for clinical practice. From a vendor perspective, validation seeks to achieve premarket approval from a regulatory agency in order for them to sell their WSI devices for an intended use (e.g., primary diagnosis). Academic validations are different, as these research studies typically result in publications reporting results of a self-defined, focused validation and their findings may not be generalizable. In general, published validation studies show good concordance for diagnoses made by WSI compared to glass slides. Clinical validation in the laboratory involves documenting the process and results of a validation study for an intended clinical use. This is typically conducted in accordance with available recommendations and/or guidelines. Validation studies comparing WSI (digital slides) to glass sides (traditional light microscopy) customarily measure concordance (agreement) between these two modalities. However, this outcome measurement can be influenced by several factors including validation study design, technology used, user training, observer variability, and case difficulty. Interobserver variability is likely to be greater than intraobserver variability, as not all pathologists may agree on certain diagnoses. Several guidelines have been developed that address WSI validation, which includes the College of American Pathologists (CAP) recommendations developed for validating WSI for diagnostic purposes. These CAP recommendations were subsequently adopted by the American Telemedicine Association (ATA) clinical guidelines for telepathology. Practical guidelines that assist pathology laboratories seeking to validate their own WSI systems for diagnostic work not only are timely but also help promote digital pathology adoption.","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125320998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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