T. Abe, Y. Murakami, M. Yamguchi, Yoshiko Yamashita, T. Kiyuna, K. Yamazaki, A. Hashiguchi, Y. Yasui, M. Kurosaki, N. Izumi, M. Sakamoto
1Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan 2Global Scientific Information and Computing Center, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan 3Medical Solutions Division, NEC Corporation, 7-1, Shiba 5-chome, Minato-ku, Tokyo 108-001, Japan 4Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino, Tokyo 180-8610, Japan
{"title":"Whole Slide Image Analysis System for Quantification of Liver Fibrosis","authors":"T. Abe, Y. Murakami, M. Yamguchi, Yoshiko Yamashita, T. Kiyuna, K. Yamazaki, A. Hashiguchi, Y. Yasui, M. Kurosaki, N. Izumi, M. Sakamoto","doi":"10.1155/2014/505968","DOIUrl":"https://doi.org/10.1155/2014/505968","url":null,"abstract":"1Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan 2Global Scientific Information and Computing Center, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan 3Medical Solutions Division, NEC Corporation, 7-1, Shiba 5-chome, Minato-ku, Tokyo 108-001, Japan 4Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino, Tokyo 180-8610, Japan","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116015636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In 2007, a modern digital pathology facility was conceived at the Telemedicine Center of the Holy Family Hospital (HFH), Rawalpindi, Pakistan, in collaboration with the Pathology Department of the Massachusetts General Hospital (MGH), Boston, USA [1]. A pathologist from HFH was trained at MGHandwas provided equipmentwith the relevant software installed. Between December 2011 and August 2012, weekly hour-long teleconferences were held between the two centers, where static histopathology images were discussed using PowerPoint.The following month, Pakistan’s first whole slide imaging (WSI) scanner was installed at the Telemedicine Center at HFH; however, before it could become functional, the pathologist left the country. The aim of the project had been for MGH to provide digital pathology support to HFH and other facilities in the country; however, the untimely exit of the trained pathologist had led to a breach in communication and a hiatus in the activities. In early 2013, we reestablished the connection, utilizing the Telemedicine Center but this time with pathologists from the Federal Government Poly Clinic (FGPC) Hospital, Islamabad. Due to the needs of teleconsultation in Pakistan, we have changed the protocol to organize teleconsultation to fit the current situation.
{"title":"Whole Slide Imaging Based Digital Pathology Network between Pakistan and USA","authors":"S. Absar, Mohammad Z. Tahir, Y. Yagi, D. Wilbur","doi":"10.1155/2014/136838","DOIUrl":"https://doi.org/10.1155/2014/136838","url":null,"abstract":"In 2007, a modern digital pathology facility was conceived at the Telemedicine Center of the Holy Family Hospital (HFH), Rawalpindi, Pakistan, in collaboration with the Pathology Department of the Massachusetts General Hospital (MGH), Boston, USA [1]. A pathologist from HFH was trained at MGHandwas provided equipmentwith the relevant software installed. Between December 2011 and August 2012, weekly hour-long teleconferences were held between the two centers, where static histopathology images were discussed using PowerPoint.The following month, Pakistan’s first whole slide imaging (WSI) scanner was installed at the Telemedicine Center at HFH; however, before it could become functional, the pathologist left the country. The aim of the project had been for MGH to provide digital pathology support to HFH and other facilities in the country; however, the untimely exit of the trained pathologist had led to a breach in communication and a hiatus in the activities. In early 2013, we reestablished the connection, utilizing the Telemedicine Center but this time with pathologists from the Federal Government Poly Clinic (FGPC) Hospital, Islamabad. Due to the needs of teleconsultation in Pakistan, we have changed the protocol to organize teleconsultation to fit the current situation.","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134078608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Emphasis of User Experience (UX) in software design has greatly contributed to the recent evolution of user interface. As consumer software and web applications become more intuitive, it is important for new software solutions entering the workspace to be more intuitive as well.
{"title":"The Importance of User Interface and User Experience in the Adoption of Whole Slide Images for Clinical Use","authors":"Christopher A. Garcia","doi":"10.1155/2014/836176","DOIUrl":"https://doi.org/10.1155/2014/836176","url":null,"abstract":"The Emphasis of User Experience (UX) in software design has greatly contributed to the recent evolution of user interface. As consumer software and web applications become more intuitive, it is important for new software solutions entering the workspace to be more intuitive as well.","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124259151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Ayad, M. Mansy, D. Elwi, M. Salem, M. Salama, K. Kayser
Optimization of workflow for breast cancer samples with equivocal HER2/neu score 2+ results in routine practice remains to be a central focus of the ongoing efforts to assess HER2 status. According to the College of American Pathologists/American Society of Clinical Oncology guidelines equivocal HER2/neu score 2+ cases are subject for further testing, usually by fluorescence in situ hybridization (FISH) investigations. It still remains on open question, whether quantitative digital image analysis of HER2 immunohistochemically (IHC) stained slides can assist in further refining the HER2 score 2+.
{"title":"Comparative Study between Quantitative Digital Image Analysis and Fluorescence In Situ Hybridization of Breast Cancer Equivocal HER2 2+ Cases","authors":"E. Ayad, M. Mansy, D. Elwi, M. Salem, M. Salama, K. Kayser","doi":"10.1155/2014/608254","DOIUrl":"https://doi.org/10.1155/2014/608254","url":null,"abstract":"Optimization of workflow for breast cancer samples with equivocal HER2/neu score 2+ results in routine practice remains to be a central focus of the ongoing efforts to assess HER2 status. According to the College of American Pathologists/American Society of Clinical Oncology guidelines equivocal HER2/neu score 2+ cases are subject for further testing, usually by fluorescence in situ hybridization (FISH) investigations. It still remains on open question, whether quantitative digital image analysis of HER2 immunohistochemically (IHC) stained slides can assist in further refining the HER2 score 2+.","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120961281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuka Nakamura, Takuya Tanaka, T. Ohnishi, Noriaki Hashimoto, H. Haneishi, Jennie W. Taylor, M. Snuderl, Y. Yagi
1Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan 2Department of Medical System Engineering, Chiba University, Chiba 263-8522, Japan 3Center for Frontier Medical Engineering, Chiba University, Chiba 263-8522, Japan 4Massachusetts General Hospital, Boston, MA 02114, USA 5New York University Langone Medical Center, New York, NY 10016, USA 6Massachusetts General Hospital Pathology Imaging and Communication Technology (PICT) Center, Boston, MA 02114, USA 7Harvard Medical School, Boston, MA 02215, USA
{"title":"Registration between Pathological Image and MR Image for Comparing Different Modality Images of Brain Tumor","authors":"Yuka Nakamura, Takuya Tanaka, T. Ohnishi, Noriaki Hashimoto, H. Haneishi, Jennie W. Taylor, M. Snuderl, Y. Yagi","doi":"10.1155/2014/430762","DOIUrl":"https://doi.org/10.1155/2014/430762","url":null,"abstract":"1Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan 2Department of Medical System Engineering, Chiba University, Chiba 263-8522, Japan 3Center for Frontier Medical Engineering, Chiba University, Chiba 263-8522, Japan 4Massachusetts General Hospital, Boston, MA 02114, USA 5New York University Langone Medical Center, New York, NY 10016, USA 6Massachusetts General Hospital Pathology Imaging and Communication Technology (PICT) Center, Boston, MA 02114, USA 7Harvard Medical School, Boston, MA 02215, USA","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130640218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Anagnostakis, Agelos Pappas, Yves Sucaet, W. Waelput
A novel recommendation for the Digital Pathology Information Web-Services (DPIWS) standard is presented, with respect to specific characteristics of the informative content of discourse. The recommendation establishes a common software interface for the exchange of digital pathology (DP) images and related metadata over the web, independently of storage, encoding, and internal handling details. The proposed structure is implemented and tested in a “Pathomation” software environment.
{"title":"Digital Pathology Data Brokerage: A Standard Recommendation for Complex Digital Pathology Information Web-Services","authors":"A. Anagnostakis, Agelos Pappas, Yves Sucaet, W. Waelput","doi":"10.1155/2014/286383","DOIUrl":"https://doi.org/10.1155/2014/286383","url":null,"abstract":"A novel recommendation for the Digital Pathology Information Web-Services (DPIWS) standard is presented, with respect to specific characteristics of the informative content of discourse. The recommendation establishes a common software interface for the exchange of digital pathology (DP) images and related metadata over the web, independently of storage, encoding, and internal handling details. The proposed structure is implemented and tested in a “Pathomation” software environment.","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123928200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Fujisawa, D. Yarilin, Ning Fan, M. Turkekul, Ke Xu, A. Barlas, K. Manova-Todorova
In many fields of biological sciences including embryology and cancer research, understanding of 3-dimensional structures is crucial to uncovering normal and pathological phenomena. While the most optimal method would be to directly observe the complete object without any destruction, staining and imaging of thick sections and whole mount samples can be challenging. For decades, researchers have serially sectioned large tissues stained each with chromogenbased immunohistologicalmethods and painstakingly reconstructed the 3-dimensional volume. The limiting factor with immunohistological staining is the difficulty in detecting multiple antigens with different chromogens on the same tissue. At our Molecular Cytology Core Facility at Memorial Sloan-Kettering Cancer Center, we successfully and routinely perform immunofluorescent staining using automated staining machines and have combined IF staining and 3D reconstruction of serial sections.This method allows simultaneous detection of up to four different antigens on the same sections in a highly reproducible and specific manner. The resulting stack can be a stunning visualization of 3D structure and be quantitatively analyzed.
{"title":"Understanding 3-Dimensional World from 2-Dimensional Immunofluorescent Adjacent Sections","authors":"S. Fujisawa, D. Yarilin, Ning Fan, M. Turkekul, Ke Xu, A. Barlas, K. Manova-Todorova","doi":"10.1155/2014/784937","DOIUrl":"https://doi.org/10.1155/2014/784937","url":null,"abstract":"In many fields of biological sciences including embryology and cancer research, understanding of 3-dimensional structures is crucial to uncovering normal and pathological phenomena. While the most optimal method would be to directly observe the complete object without any destruction, staining and imaging of thick sections and whole mount samples can be challenging. For decades, researchers have serially sectioned large tissues stained each with chromogenbased immunohistologicalmethods and painstakingly reconstructed the 3-dimensional volume. The limiting factor with immunohistological staining is the difficulty in detecting multiple antigens with different chromogens on the same tissue. At our Molecular Cytology Core Facility at Memorial Sloan-Kettering Cancer Center, we successfully and routinely perform immunofluorescent staining using automated staining machines and have combined IF staining and 3D reconstruction of serial sections.This method allows simultaneous detection of up to four different antigens on the same sections in a highly reproducible and specific manner. The resulting stack can be a stunning visualization of 3D structure and be quantitatively analyzed.","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130972752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Slawomir Walkowski, M. Lundin, J. Szymas, J. Lundin
The use of whole slide images (WSIs) allows tracking and recording how a histological slide is viewed. Gathered data about viewing behavior while interpreting WSIs may result in a variety of analyses. When the tracking is done during an exam, we can discover how students view WSIs. Moreover, we may try to correlate their way of viewing slides with correctness of the answers they give. Particularly, we can potentially find out to what extent a specific viewing behavior is likely to result in a correct or incorrect answer from a student.
{"title":"Exploring Viewing Behavior Data from Whole Slide Images to Predict Correctness of Students' Answers during Practical Exams in Oral Pathology","authors":"Slawomir Walkowski, M. Lundin, J. Szymas, J. Lundin","doi":"10.1155/2014/706470","DOIUrl":"https://doi.org/10.1155/2014/706470","url":null,"abstract":"The use of whole slide images (WSIs) allows tracking and recording how a histological slide is viewed. Gathered data about viewing behavior while interpreting WSIs may result in a variety of analyses. When the tracking is done during an exam, we can discover how students view WSIs. Moreover, we may try to correlate their way of viewing slides with correctness of the answers they give. Particularly, we can potentially find out to what extent a specific viewing behavior is likely to result in a correct or incorrect answer from a student.","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115244753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Use of Virtual Microscopy and a Wiki in Pathology Education: Tracking Student Use, Involvement, and Response","authors":"Z. Leifer","doi":"10.1155/2014/274134","DOIUrl":"https://doi.org/10.1155/2014/274134","url":null,"abstract":"","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"263 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122701318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Ohnishi, Takuya Tanaka, Yuka Nakamura, Noriaki Hashimoto, H. Haneishi, Jennie W. Taylor, M. Snuderl, Y. Yagi
1 Center for Frontier Medical Engineering, Chiba University, Chiba 263-8522, Japan 2Department of Medical System Engineering, Chiba University, Chiba 263-8522, Japan 3 Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan 4Massachusetts General Hospital, Boston, MA 02114, USA 5New York University Langone Medical Center, New York, NY 10016, USA 6Massachusetts General Hospital Pathology Imaging and Communication Technology (PICT) Center, Boston, MA 02114, USA 7Harvard Medical School, Boston, MA 02215, USA
{"title":"Connection and Deformation of Pathological Images via a Macro Image for Comparing Different Modality Images of Brain Tumor","authors":"T. Ohnishi, Takuya Tanaka, Yuka Nakamura, Noriaki Hashimoto, H. Haneishi, Jennie W. Taylor, M. Snuderl, Y. Yagi","doi":"10.1155/2014/368951","DOIUrl":"https://doi.org/10.1155/2014/368951","url":null,"abstract":"1 Center for Frontier Medical Engineering, Chiba University, Chiba 263-8522, Japan 2Department of Medical System Engineering, Chiba University, Chiba 263-8522, Japan 3 Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan 4Massachusetts General Hospital, Boston, MA 02114, USA 5New York University Langone Medical Center, New York, NY 10016, USA 6Massachusetts General Hospital Pathology Imaging and Communication Technology (PICT) Center, Boston, MA 02114, USA 7Harvard Medical School, Boston, MA 02215, USA","PeriodicalId":313227,"journal":{"name":"Analytical Cellular Pathology (Amsterdam)","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122353860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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