Pub Date : 2019-06-28DOI: 10.21272/EUMJ.2019;7(2):142-147
O. Kocherzhat
Purpose. Тo assess the indicators of early predictors of NAFLD in patients with MS by assessing the functional state of the liver and systemic inflammation, depending on the degree of obesity. Material and methods. The study included 90 patients with NAFLD, divided in to 3 groups: group 1 – 30 patients with NADH without MS, group 2 – patients with NADH combined with MS: with BMI 25 – 29.9 kg/m 2 (n = 30) – group 2a, with BMI > 30 kg/m 2 (n = 30) – group 2b. The control group consisted of 20 apparently healthy individuals. All patients were evaluated for the activity of ALT, AST, LDH, SDH, CHE, total bilirubin level; levels of leptin, adiponectin, TNF-α. Results. Significant increase in the level of SDH in patients of both groups was found. In patients of group 2a LDH level exceeded the value in healthy persons by 2.5 times (p < 0.05) and was 1.3 times higher than in patients of group 1 (p < 0.05); in patients of group 2b was exceeded the control index in 3.7 times (p < 0.05), in 1,6 times as compared to the patients of group 1 (p < 0.05) and 1,3 times in comparison with patients of group 2a (p < 0.05). The activity of CHE in patients of group 1 significantly was not different from the index of control (p > 0.05), in patients of group 2b significant decrease of CHE activity was found (р < 0.05). The presence of hyperleptinemia, hypoadiponectinemia, and systemic inflammatory response according to the level of TNF -α was characteristic for patients with NAFLD and MS. Conclusions. Hyperleptinemia, hypoadiponectinemia, the presence of a systemic inflammatory response to the level of TNF-α, and a violation of the synthetic and detoxification functions of the liver, which are more pronounced in patients with NAFLD and MS with concomitant obesity of І–ІІІ degrees, can be considered not only as markers of preclinical lesions of target organs, but and as an indicators of the severity of the combined flow of NAFLD and MS.
{"title":"EVALUATION OF MARKERS OF TARGET ORGANS PRECLINICAL DAMAGE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE COMBINED WITH METABOLIC SYNDROME DEPENDING ON THE OBESITY STAGE","authors":"O. Kocherzhat","doi":"10.21272/EUMJ.2019;7(2):142-147","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(2):142-147","url":null,"abstract":"Purpose. Тo assess the indicators of early predictors of NAFLD in patients with MS by assessing the functional state of the liver and systemic inflammation, depending on the degree of obesity. Material and methods. The study included 90 patients with NAFLD, divided in to 3 groups: group 1 – 30 patients with NADH without MS, group 2 – patients with NADH combined with MS: with BMI 25 – 29.9 kg/m 2 (n = 30) – group 2a, with BMI > 30 kg/m 2 (n = 30) – group 2b. The control group consisted of 20 apparently healthy individuals. All patients were evaluated for the activity of ALT, AST, LDH, SDH, CHE, total bilirubin level; levels of leptin, adiponectin, TNF-α. Results. Significant increase in the level of SDH in patients of both groups was found. In patients of group 2a LDH level exceeded the value in healthy persons by 2.5 times (p < 0.05) and was 1.3 times higher than in patients of group 1 (p < 0.05); in patients of group 2b was exceeded the control index in 3.7 times (p < 0.05), in 1,6 times as compared to the patients of group 1 (p < 0.05) and 1,3 times in comparison with patients of group 2a (p < 0.05). The activity of CHE in patients of group 1 significantly was not different from the index of control (p > 0.05), in patients of group 2b significant decrease of CHE activity was found (р < 0.05). The presence of hyperleptinemia, hypoadiponectinemia, and systemic inflammatory response according to the level of TNF -α was characteristic for patients with NAFLD and MS. Conclusions. Hyperleptinemia, hypoadiponectinemia, the presence of a systemic inflammatory response to the level of TNF-α, and a violation of the synthetic and detoxification functions of the liver, which are more pronounced in patients with NAFLD and MS with concomitant obesity of І–ІІІ degrees, can be considered not only as markers of preclinical lesions of target organs, but and as an indicators of the severity of the combined flow of NAFLD and MS.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"30 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121003953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-28DOI: 10.21272/EUMJ.2019;7(2):116-120
A. Sukharev
{"title":"CONDITION OF THE UTERINE CERVIX DURING UNCOMPLICATED MULTIPLE PREGNANCY","authors":"A. Sukharev","doi":"10.21272/EUMJ.2019;7(2):116-120","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(2):116-120","url":null,"abstract":"","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115761526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-28DOI: 10.21272/EUMJ.2019;7(2):96-108
A. Piddubnyi, R. Moskalenko
This review is devoted to the topical issue of modern medicine – the molecular mechanisms and factors for the development of bone metastases of malignant tumors, in particular prostate cancer. The recent publication on the formation and progression of prostate cancer bone metastases were analyzed in this study. The expression of some molecular markers in tumor and metastatic tissue and their role in tumor progression were also analyzed in this study. A common concept for the development of specific metastases is a seed and soil theory. According to this concept, circulating cancer cells recognize some organs as the optimal microenvironment for their development. However, the molecular mechanisms of this phenomenon remain unknown. Molecular and genetic features of the androgen receptors expression in the tumor and their role in metastatic tissue were summarized and compared in this study. We also demonstrated the effect of these receptors on the development of osteoblastic metastases and castration-resistant prostate cancer. Authors analyzed and summarized data about the role of p53 protein, Bax and activated caspase 3 in apoptosis, mechanisms of neoangiogenesis and remodeling of tumor connective tissue with matrix metalloproteinase 1, the presence of collagen type I and osteonectin in neoplastic tissues and the role of inflammation in metastasis development. Functions of heat shock proteins with molecular masses of 70 and 90 kDa and their role in tumor and metastatic tissue were also analyzed. Thus, the study complements and summarizes the data on the development of bone metastases of prostate cancer. The study analyzed the molecular characteristics of prostate cancer during its metastatic spread.
{"title":"MOLECULAR ASPECTS OF THE BONE METASTASTASES DEVELOPMENT IN PROSTATE CANCER","authors":"A. Piddubnyi, R. Moskalenko","doi":"10.21272/EUMJ.2019;7(2):96-108","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(2):96-108","url":null,"abstract":"This review is devoted to the topical issue of modern medicine – the molecular mechanisms and factors for the development of bone metastases of malignant tumors, in particular prostate cancer. The recent publication on the formation and progression of prostate cancer bone metastases were analyzed in this study. \u0000The expression of some molecular markers in tumor and metastatic tissue and their role in tumor progression were also analyzed in this study. A common concept for the development of specific metastases is a seed and soil theory. According to this concept, circulating cancer cells recognize some organs as the optimal microenvironment for their development. However, the molecular mechanisms of this phenomenon remain unknown. \u0000Molecular and genetic features of the androgen receptors expression in the tumor and their role in metastatic tissue were summarized and compared in this study. We also demonstrated the effect of these receptors on the development of osteoblastic metastases and castration-resistant prostate cancer. Authors analyzed and summarized data about the role of p53 protein, Bax and activated caspase 3 in apoptosis, mechanisms of neoangiogenesis and remodeling of tumor connective tissue with matrix metalloproteinase 1, the presence of collagen type I and osteonectin in neoplastic tissues and the role of inflammation in metastasis development. Functions of heat shock proteins with molecular masses of 70 and 90 kDa and their role in tumor and metastatic tissue were also analyzed. Thus, the study complements and summarizes the data on the development of bone metastases of prostate cancer. The study analyzed the molecular characteristics of prostate cancer during its metastatic spread.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115500447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-28DOI: 10.21272/EUMJ.2019;7(2):148-158
V. Bezugla, L. Gunina, Yu. D. Vinnichuk, V. Klapchuk
Introduction. Modern sport of the highest achievements is inextricably linked with the constant physical activity of high intensity, which ultimately leads to the formation of overvoltage phenomena of various body systems. The purpose. To substantiate the expediency of appointment of athletes with clinical and instrumental signs of the cardiomyopathy, caused by chronic physical overload (CMPCPO) of the metabolic preparation Cardonat on the basis of evaluation of its influence on the indices of biochemical and hormonal homeostasis. Materials and methods. The study involved 48 athletes, representatives of cyclic sports, with a diagnosis CMPCPO who were randomized to 2 equivalent (n = 24) groups: the main group and the controls. The volume and intensity of training loads was reduced in athletes of both groups by 75%. The control group participants received only basic therapy (the combination of the drug panangin (potassium and magnesium aspartate) and the drug Trіovіt, at therapeutic doses of vitamin-mineral orientation and placebo (capsule with starch). Athletes of the main group in addition to basic therapy used Cardonat for one capsule three times a day for 4 weeks. A comprehensive laboratory study of athletes before and after the course of treatment included a study of the indicators of biochemical and hormonal homeostasis, as well as prooxidant-antioxidant balance. Results. The addition of Cardonat to the complex therapy of athletes from the CMPCPO during the month is accompanied by a positive effect on the structural characteristics of the erythrocyte membranes of the athletes, which is reflected in the improvement of the state of prooxidant-antioxidant equilibrium: in the representatives of the main group, the administration of the drug caused a statistically significant decrease, compared with the data in the control group, malodialdehyde (MDA), increase in the concentration of reduced glutathione (GSH) in erythrocyte membranes and decrease of prooxidant-antioxidant coefficient (Cpa), indicating the predominance of antioxidant processes over lipopereoxidation processes. It is also shown that taking a Cardonat with athletes with manifestations CMPCPO is not accompanied by negative changes in standard laboratory biochemical parameters that reflect the functional state of various organs and systems of the body's organs. The decrease in the activity of aspartate aminotransferase (AST) and the tendency towards a more pronounced decrease in alanine aminotransferase (ALT), α-amylase and urea content in comparison with the values of the corresponding indices in the control group, confirms the positive effect of the drug on the functional state of the liver and pancreas. Indicators of hormonal homeostasis are indicative of improving the ratio of anabolic and catabolic processes in the body of athletes and reducing the level of stress due to the use of the drug. Thus, after taking Cardonat in the main group, testosterone levels increased by 31.6 %
{"title":"INFLUENCE OF CARDONAT ON INDICATORS OF BIOCHEMICAL AND HORMONAL HOMEOSTASIS IN SPORTSMANS WITH CARDIOMYOPATHY AFTER PHYSICAL OVERLOAD","authors":"V. Bezugla, L. Gunina, Yu. D. Vinnichuk, V. Klapchuk","doi":"10.21272/EUMJ.2019;7(2):148-158","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(2):148-158","url":null,"abstract":"Introduction. Modern sport of the highest achievements is inextricably linked with the constant physical activity of high intensity, which ultimately leads to the formation of overvoltage phenomena of various body systems. \u0000The purpose. To substantiate the expediency of appointment of athletes with clinical and instrumental signs of the cardiomyopathy, caused by chronic physical overload (CMPCPO) of the metabolic preparation Cardonat on the basis of evaluation of its influence on the indices of biochemical and hormonal homeostasis. \u0000Materials and methods. The study involved 48 athletes, representatives of cyclic sports, with a diagnosis CMPCPO who were randomized to 2 equivalent (n = 24) groups: the main group and the controls. The volume and intensity of training loads was reduced in athletes of both groups by 75%. The control group participants received only basic therapy (the combination of the drug panangin (potassium and magnesium aspartate) and the drug Trіovіt, at therapeutic doses of vitamin-mineral orientation and placebo (capsule with starch). Athletes of the main group in addition to basic therapy used Cardonat for one capsule three times a day for 4 weeks. A comprehensive laboratory study of athletes before and after the course of treatment included a study of the indicators of biochemical and hormonal homeostasis, as well as prooxidant-antioxidant balance. \u0000Results. The addition of Cardonat to the complex therapy of athletes from the CMPCPO during the month is accompanied by a positive effect on the structural characteristics of the erythrocyte membranes of the athletes, which is reflected in the improvement of the state of prooxidant-antioxidant equilibrium: in the representatives of the main group, the administration of the drug caused a statistically significant decrease, compared with the data in the control group, malodialdehyde (MDA), increase in the concentration of reduced glutathione (GSH) in erythrocyte membranes and decrease of prooxidant-antioxidant coefficient (Cpa), indicating the predominance of antioxidant processes over lipopereoxidation processes. It is also shown that taking a Cardonat with athletes with manifestations CMPCPO is not accompanied by negative changes in standard laboratory biochemical parameters that reflect the functional state of various organs and systems of the body's organs. The decrease in the activity of aspartate aminotransferase (AST) and the tendency towards a more pronounced decrease in alanine aminotransferase (ALT), α-amylase and urea content in comparison with the values of the corresponding indices in the control group, confirms the positive effect of the drug on the functional state of the liver and pancreas. Indicators of hormonal homeostasis are indicative of improving the ratio of anabolic and catabolic processes in the body of athletes and reducing the level of stress due to the use of the drug. Thus, after taking Cardonat in the main group, testosterone levels increased by 31.6 % ","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122987622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-29DOI: 10.21272/EUMJ.2019;7(1):28-38
N. Malysh, M. Chemych, O. Kuzmenko
standard" microbiological indicators of meat and meat products. Thus, identifying risk factors for epidemic situation and using a mathematical model to predict the development of the epidemic process of acute intestinal infections, taking into account demographic indicators and socio-hygienic monitoring data can be an important part of the system for improving epidemiological surveillance.
{"title":"OPTIMIZATION OF EPIDEMIOLOGICAL SUPERVISION FOR ACUTE INTESTINAL INFECTIONS IN UKRAINE","authors":"N. Malysh, M. Chemych, O. Kuzmenko","doi":"10.21272/EUMJ.2019;7(1):28-38","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(1):28-38","url":null,"abstract":"standard\" microbiological indicators of meat and meat products. Thus, identifying risk factors for epidemic situation and using a mathematical model to predict the development of the epidemic process of acute intestinal infections, taking into account demographic indicators and socio-hygienic monitoring data can be an important part of the system for improving epidemiological surveillance.","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128821963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-29DOI: 10.21272/EUMJ.2019;7(1):39-47
Е. J. Arhij, L. Prylypko, B. Halay
{"title":"EVALUATION OF EXOCRINE PANCREATIC FUNCTION IN PATIENTS WITH CHRONIC PANCREATITIS IN COMBINATION WITH HYPERTENSION","authors":"Е. J. Arhij, L. Prylypko, B. Halay","doi":"10.21272/EUMJ.2019;7(1):39-47","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(1):39-47","url":null,"abstract":"","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128917240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-29DOI: 10.21272/EUMJ.2019;7(1):11-19
Y. L. Kovalenko
{"title":"HYPERURICEMIA AS A RISK FACTOR OF ARTERIAL HYPERTENSION","authors":"Y. L. Kovalenko","doi":"10.21272/EUMJ.2019;7(1):11-19","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(1):11-19","url":null,"abstract":"","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116997691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-29DOI: 10.21272/EUMJ.2019;7(1):66-71
M. Melnychuk
{"title":"EFFECTIVENESS OF 5-ALPHA-REDUCTASE INHIBITORS IN PATIENTS WITH PROSTATIC INTRAEPITHELIAL NEOPLASIA OF PERIPHERAL PROSTATE ZONE","authors":"M. Melnychuk","doi":"10.21272/EUMJ.2019;7(1):66-71","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(1):66-71","url":null,"abstract":"","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116238715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-29DOI: 10.21272/EUMJ.2019;7(1):81-93
A. Kustov, A. M. Chikmariоva
{"title":"THE STRUCTURE OF THE QUALITIES WHICH CAUSES TRUST TO THE DOCTOR","authors":"A. Kustov, A. M. Chikmariоva","doi":"10.21272/EUMJ.2019;7(1):81-93","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(1):81-93","url":null,"abstract":"","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133825871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-29DOI: 10.21272/EUMJ.2019;7(1):72-80
I. Delva
Introduction. Post-stroke fatigue (PSF) is a common complication of acute cerebrovascular events (ACE) that occurs in about 50% of patients within the first post-stroke year. It is well-known that PSF has multiple negative influences on post-stroke rehabilitation, life quality, mortality rates and so on. Purpose: find possible associations between ambulatory pharmacotherapy since hospital discharge and regularities of PSF onset and PSF clinical course within the first year after ACE occurrence. Material and methods. The study included 318 patients with ACE (217 had ischemic strokes, 39 – hemorrhagic strokes and 62 – transient ischemic attacks). Exclusion criteria were major medical illness that could cause secondary fatigue (oncological, hematological diseases, cardiac, liver, kidney and respiratory insufficiency, progressive angina pectoris, acute myocardial infarction), alcohol abuse, consciousness impairments, insufficient cognitive ability (Mini-Mental State Examination scores less than 24), depressive and anxious disorders (Hospital Anxiety and Depression Scale scores more than 10 for both pathologies), impaired speech function to participate (severe dysphasia or dysarthria), impaired language or written ability to complete the study questionnaires, severe functional disabilities (modified Rankin scale scores ≥ 4). Patients' characteristics were evaluated at definite time points: in 1, 3, 6, 9 and 12 months after ACE occurrence. PSF and its components were measured by three self-report questionnaires: fatigue assessment scale (FAS), fatigue severity scale (FSS) and multidimensional fatigue inventory-20 (MFI-20). PSF characteristics included time of occurrence, time of disappearance, duration, intensity. Characteristics of hospital pharmacotherapy (groups of used drugs, number of drugs prescribed for patient) were analyzed using a special algorithm. Results and discussion. There were no associations between any drug group prescriptions as well as between number of used drugs and PSF characteristics (rates and intensities) according to all used scales within the whole one-year observation period. There were no association between the number of used drugs and number of new PSF cases that were diagnosed in 1 month and in 3 months after ACE occurrence. Also, we didn’t find any significant correlation between number of used drugs and risk of PSF prolongation during one year observation period. None of the drug groups (with the exception of beta-blockers) was associated with a significant change of PSF intensity during the first post-stroke year. Finally, beta-blockers usage during the first post-stroke year was associated with statistically significant increase of PSF intensity (according to FAS) in 1, 3 and 6 months after ACE. Moreover, there was statistically significant association between beta-blockers intake and increasing intensity of the most of PSF components (according to MFI‑20): global PSF in 1, 3 and 6 months, physical PSF in 3 mont
{"title":"POST-STROKE FATIGUE AND AMBULATORY PHARMACOTHERAPY AFTER ACUTE CEREBROVASCULAR EVENTS","authors":"I. Delva","doi":"10.21272/EUMJ.2019;7(1):72-80","DOIUrl":"https://doi.org/10.21272/EUMJ.2019;7(1):72-80","url":null,"abstract":"Introduction. Post-stroke fatigue (PSF) is a common complication of acute cerebrovascular events (ACE) that occurs in about 50% of patients within the first post-stroke year. It is well-known that PSF has multiple negative influences on post-stroke rehabilitation, life quality, mortality rates and so on. \u0000Purpose: find possible associations between ambulatory pharmacotherapy since hospital discharge and regularities of PSF onset and PSF clinical course within the first year after ACE occurrence. \u0000Material and methods. The study included 318 patients with ACE (217 had ischemic strokes, 39 – hemorrhagic strokes and 62 – transient ischemic attacks). Exclusion criteria were major medical illness that could cause secondary fatigue (oncological, hematological diseases, cardiac, liver, kidney and respiratory insufficiency, progressive angina pectoris, acute myocardial infarction), alcohol abuse, consciousness impairments, insufficient cognitive ability (Mini-Mental State Examination scores less than 24), depressive and anxious disorders (Hospital Anxiety and Depression Scale scores more than 10 for both pathologies), impaired speech function to participate (severe dysphasia or dysarthria), impaired language or written ability to complete the study questionnaires, severe functional disabilities (modified Rankin scale scores ≥ 4). Patients' characteristics were evaluated at definite time points: in 1, 3, 6, 9 and 12 months after ACE occurrence. PSF and its components were measured by three self-report questionnaires: fatigue assessment scale (FAS), fatigue severity scale (FSS) and multidimensional fatigue inventory-20 (MFI-20). PSF characteristics included time of occurrence, time of disappearance, duration, intensity. Characteristics of hospital pharmacotherapy (groups of used drugs, number of drugs prescribed for patient) were analyzed using a special algorithm. \u0000Results and discussion. There were no associations between any drug group prescriptions as well as between number of used drugs and PSF characteristics (rates and intensities) according to all used scales within the whole one-year observation period. There were no association between the number of used drugs and number of new PSF cases that were diagnosed in 1 month and in 3 months after ACE occurrence. Also, we didn’t find any significant correlation between number of used drugs and risk of PSF prolongation during one year observation period. None of the drug groups (with the exception of beta-blockers) was associated with a significant change of PSF intensity during the first post-stroke year. Finally, beta-blockers usage during the first post-stroke year was associated with statistically significant increase of PSF intensity (according to FAS) in 1, 3 and 6 months after ACE. Moreover, there was statistically significant association between beta-blockers intake and increasing intensity of the most of PSF components (according to MFI‑20): global PSF in 1, 3 and 6 months, physical PSF in 3 mont","PeriodicalId":315243,"journal":{"name":"Eastern Ukrainian Medical Journal","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124807969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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