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2003 IEEE XIII Workshop on Neural Networks for Signal Processing (IEEE Cat. No.03TH8718)最新文献

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Computational decomposition of molecular signatures based on blind source separation of non-negative dependent sources with NMF 基于NMF的非负相关源盲分离的分子特征计算分解
Junying Zhang, Le Wei, Y. Wang
As a common feature in microarray profiling, gene expression profiles represent a composite of more than one distinct sources, which can severely decrease the sensitivity and specificity for the measurement of molecular signatures associated with different disease processes. Independent component analysis (ICA) is a widely applicable approach in blind source separation (BSS) but with limitations that the sources are independent, while a more common situation, which still happens in microarray profiles, is BSS where sources are not statistically independent. A novel idea of BSS is presented: it is a matrix factorization problem without enforcement of statistical characteristics on sources, while blind independent source separation is in fact matrix factorization, to factorize the observation matrix into a mixing matrix and a source matrix where the sources are independent. Since non-negative sources are meaningful in many applications including microarray profiling, we presented that blind non-negative source separation is essentially a matrix factorization, to factorize the observation matrix into a non-negative mixing matrix and a non-negative source matrix where the sources may be dependent. Non-negative matrix factorization (NMF) technique is applied to this non-negative source separation and is proven by a large number of computer simulations and by partial volume correction (PVC) experiments for real microarray data that it is effective when the sources are dependent with each other and/or are Gaussian distributed.
作为微阵列谱分析的一个共同特征,基因表达谱代表了一个以上不同来源的组合,这可能严重降低与不同疾病过程相关的分子特征测量的敏感性和特异性。独立分量分析(ICA)是一种广泛应用于盲源分离(BSS)的方法,但存在源独立的局限性,而在微阵列谱图中更常见的情况是源不统计独立的BSS。提出了一种新的BSS思想:它是一个不强加于源的统计特征的矩阵分解问题,而盲独立源分离实际上是矩阵分解,将观测矩阵分解为源独立的混合矩阵和源矩阵。由于非负源在包括微阵列分析在内的许多应用中都有意义,我们提出了盲非负源分离本质上是矩阵分解,将观测矩阵分解为非负混合矩阵和非负源矩阵,其中源可能是相关的。非负矩阵分解(NMF)技术被应用于这种非负源分离,并被大量的计算机模拟和对真实微阵列数据的部分体积校正(PVC)实验证明,当源相互依赖和/或高斯分布时,它是有效的。
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引用次数: 9
Fast error whitening algorithms for system identification and control 用于系统识别和控制的快速错误白化算法
Y. Rao, Deniz Erdoğmuş, G. Y. Rao, J. Príncipe
Linear system identification with noisy inputs is a critical problem in signal processing and control. Conventional techniques based on the mean squared-error (MSE) criterion can at best provide a biased estimate of the unknown system being modeled. Recently, we proposed a new criterion called the error whitening criterion (EWC) to solve the problem of linear parameter estimation in the presence of additive white noise. In this paper, we present a fixed-point type algorithm with O(N/sup 2/) complexity for EWC, called the recursive error whitening (REW) algorithm. We would also show that the EWC solution could be solved using the computational principles of total least squares (TLS). A novel EWC-TLS algorithm with O(N/sup 2/) complexity is derived. We will then apply the EWC methods for adaptive inverse control and show the superiority over existing methods.
具有噪声输入的线性系统辨识是信号处理和控制中的一个关键问题。基于均方误差(MSE)准则的传统方法最多只能对被建模的未知系统提供有偏估计。为了解决存在加性白噪声的线性参数估计问题,本文提出了一种新的误差白化准则(EWC)。本文提出了一种复杂度为0 (N/sup 2/)的EWC不动点算法,称为递归误差白化(REW)算法。我们还将证明EWC解可以使用总最小二乘(TLS)的计算原理来求解。提出了一种复杂度为0 (N/sup 2/)的EWC-TLS算法。然后,我们将EWC方法应用于自适应逆控制,并展示其优于现有方法的优越性。
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引用次数: 6
Neuro-variational inversion of ocean color imagery 海洋色彩图像的神经变分反演
C. Jamet, S. Thiria, C. Moulin, M. Crépon
This paper presents a neuro-variational method to invert satellite ocean color signal. The method is based on a combination of neural networks and classical variational inversion. The radiative transfer equations are modeled by neural networks whose input are the oceanic and atmospheric parameters and output the top of the atmosphere reflectance at several wavelengths. The procedure consists in minimizing a quadratic cost function which is the distance between the satellite observed reflectance and the neural network computed reflectance, the control parameters being the oceanic and atmospheric parameters. The method allows us to retrieve atmospheric and oceanic parameters. We present a feasibility experiment. We show we can retrieve Chl-a with an error of 19.7% if we can obtain a perfect knowledge of three atmospheric parameters. Finally, an inversion of one SeaWiFS image is presented. The Chl-a give coherent spatial structures.
提出了一种基于神经变分的卫星海洋颜色信号反演方法。该方法将神经网络与经典变分反演相结合。用神经网络模拟辐射传输方程,神经网络输入海洋和大气参数,输出几个波长的大气顶部反射率。该过程包括最小化一个二次代价函数,即卫星观测反射率与神经网络计算反射率之间的距离,控制参数为海洋和大气参数。这种方法使我们能够检索大气和海洋参数。我们提出了一个可行性实验。结果表明,如果能获得三个大气参数的完整信息,则可以获得误差为19.7%的Chl-a。最后,给出了一幅SeaWiFS图像的反演结果。Chl-a给出了连贯的空间结构。
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引用次数: 0
Iterated extended Kalman smoothing with expectation-propagation 迭代扩展卡尔曼平滑与期望传播
A. Ypma, T. Heskes
We formulate extended Kalman smoothing in an expectation-propagation (EP) framework. The approximation involved (a local linearization) can be looked upon as a 'collapse' of a non-Gaussian belief state onto a Gaussian form. This formulation allows us to come up with better approximations to the belief states, since we can iterate the algorithm until no further refinement of the beliefs is obtained. Compared to the standard extended Kalman smoother, we linearize around the mode of the actual two-slice belief state instead of the predicted mean of the one-slice belief. In initial experiments with a one-dimensional nonlinear dynamical system we found that our method improves over the extended Kalman filter and performs comparable to the unscented Kalman filter, whereas only second-order approximations are being made. The EP-formulation in principle allows for incorporation of higher-order approximations, possibly leading to further improvements.
我们在期望传播(EP)框架内对扩展卡尔曼平滑法进行了阐述。所涉及的近似(局部线性化)可视为将非高斯信念状态 "折叠 "为高斯形式。由于我们可以对算法进行迭代,直到不再对信念进行细化,因此这种表述方式能让我们得出更好的信念状态近似值。与标准的扩展卡尔曼平滑器相比,我们围绕实际两片信念状态的模式进行线性化,而不是单片信念的预测平均值。在对一维非线性动态系统的初步实验中,我们发现我们的方法比扩展卡尔曼滤波法有了改进,其性能可与无特征卡尔曼滤波法媲美,而我们只做了二阶近似。EP 公式原则上允许纳入更高阶的近似值,从而可能带来进一步的改进。
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引用次数: 4
Bayesian processing of microarray images 微阵列图像的贝叶斯处理
Neil D. Lawrence, M. Milo, M. Niranjan, P. Rashbass, S. Soullier
Gene expression measurements quantify the level of mRNA produced from each gene. Two principal methods exist for producing slides for extracting these levels: photolithography and spotted arrays. One difficulty with the spotted array format is determining the size and location of the spots on the array. In this paper we present a Bayesian approach to processing images produced by these arrays that seeks posterior distributions over the size and positions of the spots. This enables us to estimate expression ratios and their variances. Exact inference for the model we specify is intractable; we develop an approximate inference technique, which combines importance sampling with variational inference. Our technique has already been shown to be more consistent than both manual processing and another automated technique [N. D. Lawrence, et al., "Reducing the Variability in cDNA Microarray Image Processing by Inference"]. Here we present large-scale results for twenty-four microarray slides each representing 5760 genes and show the dramatic effects of incorporating variance in our downstream analysis. Software based on this algorithm is available for academic use.
基因表达测量量化每个基因产生的mRNA水平。有两种主要的方法用于生产用于提取这些水平的载玻片:光刻和点阵。斑点阵列格式的一个难点是确定阵列上斑点的大小和位置。在本文中,我们提出了一种贝叶斯方法来处理由这些阵列产生的图像,该阵列寻求斑点大小和位置的后验分布。这使我们能够估计表达比率及其方差。我们指定的模型的精确推断是难以处理的;我们开发了一种将重要抽样和变分推理相结合的近似推理技术。我们的技术已经被证明比手工处理和另一种自动化技术更加一致。D. Lawrence等人,“通过推理减少cDNA微阵列图像处理的可变性”。在这里,我们展示了24张微阵列载玻片的大规模结果,每张载玻片代表5760个基因,并显示了在我们的下游分析中纳入方差的巨大影响。基于该算法的软件可用于学术用途。
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引用次数: 6
Blind equalization using matrix momentum and natural gradient adaptation 利用矩阵动量和自然梯度自适应进行盲均衡
G. Morison, T. Durrani
In this paper the problem of single input multiple output (SIMO) and multiple input multiple output (MIMO) blind equalization in a frequency selective environment is addressed using blind source separation techniques. A robust whitening stage is included to reduce the effects of noise enhancement that traditional prewhitening methods suffer, and the use of matrix momentum with the natural gradient algorithm is utilised to improve the computation efficiency of the standard natural gradient algorithm. The performance of the algorithm is demonstrated for an ill conditioned channel and compared with a current natural gradient based blind equalization using source separation method.
本文利用盲源分离技术解决了频率选择环境下的单输入多输出(SIMO)和多输入多输出(MIMO)盲均衡问题。该方法引入了鲁棒白化阶段,减少了传统预白化方法中噪声增强的影响,并将矩阵动量与自然梯度算法结合使用,提高了标准自然梯度算法的计算效率。在病态信道条件下验证了该算法的性能,并与现有的基于自然梯度的源分离盲均衡方法进行了比较。
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引用次数: 0
Partially-independent component analysis for tissue heterogeneity correction in microarray gene expression analysis 微阵列基因表达分析中组织异质性校正的部分独立成分分析
Y. Wang, Junying Zhang, Javed I. Khan, R. Clarke, Zhiping Gu
Gene microarray technologies provide powerful tools for the large scale analysis of gene expression in cancer research. Clinical applications often aim to facilitate a molecular classification of cancers based on discriminatory genes associated with different clinical stages or outcomes. However, gene expression profiles often represent a composite of more than one distinct source due to tissue heterogeneity, and could result in extracting signatures reflecting the proportion of stromal contamination in the sample, rather than underlying tumor biology. We therefore wish to introduce a computational approach, which allows for a blind decomposition of gene expression profiles from mixed cell populations. The algorithm is based on a linear latent variable model, whose parameters are estimated using partially-independent component analysis, supported by a subset of differentially-expressed genes. We demonstrate the principle of the approach on the data sets derived from mixed cell lines of small round blue cell tumors. Because accurate source separation can be achieved blindly and numerically, we anticipate that computational correction of tissue heterogeneity would be useful in a wide variety of gene microarray studies.
基因微阵列技术为癌症研究中基因表达的大规模分析提供了强有力的工具。临床应用通常旨在促进基于与不同临床阶段或结果相关的歧视性基因的癌症分子分类。然而,由于组织异质性,基因表达谱通常代表多个不同来源的组合,并且可能导致提取反映样品中基质污染比例的特征,而不是潜在的肿瘤生物学。因此,我们希望引入一种计算方法,它允许从混合细胞群体中盲分解基因表达谱。该算法基于线性潜变量模型,其参数使用部分独立成分分析进行估计,并由一组差异表达基因支持。我们在小圆形蓝细胞肿瘤混合细胞系的数据集上展示了该方法的原理。由于精确的源分离可以盲目地和数字地实现,我们预计组织异质性的计算校正将在各种基因微阵列研究中有用。
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引用次数: 9
Architecture of an intelligent beacon for wireless sensor networks 无线传感器网络智能信标的体系结构
P. Garda, O. Romain, B. Granado, A. Pinna, D. Faura, K. Hachicha
In this paper, we introduce the architecture of an intelligent beacon for wireless sensor networks. This beacon acquires images of a scene and detects motion, thanks to the real-time execution of a Markov motion detection algorithm. When some motion is detected, neural networks are applied in real-time to the acquired images in order to trigger some alarm. Finally, when some alarm is triggered, video of the scene compressed with the MMJPEG2000 algorithm are sent on a wireless network, a long-range communication by satellite for example. The beacon is implemented on a platform including a microcontroller, a DSP, an FPGA and several dedicated modules.
本文介绍了一种用于无线传感器网络的智能信标的结构。该信标获取场景图像并检测运动,这要归功于马尔可夫运动检测算法的实时执行。当检测到某些运动时,将神经网络实时应用于采集到的图像,以触发某些报警。最后,当报警触发时,通过MMJPEG2000算法压缩的现场视频通过无线网络发送,例如通过卫星进行远程通信。信标是在一个平台上实现的,该平台包括一个微控制器、一个DSP、一个FPGA和几个专用模块。
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引用次数: 9
Independent components analysis for fetal electrocardiogram extraction: a case for the data efficient Mermaid algorithm 胎儿心电图提取的独立分量分析:以数据高效的Mermaid算法为例
Dorothee E. Marossero, Deniz Erdoğmuş, N. Euliano, J. Príncipe, K. Hild
Fetal heart rate (FHR) monitoring is currently the primary methodology for antenatal determination of fetal well-being. Currently, the FHR can be detected with ultrasonography, but the additional information from fetal electrocardiogram (FECG) is only available via an invasive scalp electrode. A cost effective noninvasive monitoring through standard ECG electrodes could be used on nearly every patient in lieu of the ultrasound monitors. In this method, a number of electrodes are positioned on the abdomen of the mother to collect, simultaneously, various combinations of the signals including the heartbeats of the mother and the fetus. For accurate fetal heart-rate estimation, a clean FECG must be extracted from the collected mixtures. It is well known that this can be achieved using blind source separation (BSS) techniques. In this paper, the performance of the Mermaid algorithm, which is based on minimizing Renyi's mutual information, is evaluated on this problem of great practical importance. The effectiveness and data efficiency of Mermaid and its superiority over alternative information theoretic BSS algorithms are illustrated using artificially mixed ECG signals as well as fetal heart rate estimates in real ECG mixtures.
胎儿心率(FHR)监测是目前胎儿健康产前测定的主要方法。目前,FHR可以通过超声波检测,但胎儿心电图(FECG)的附加信息只能通过侵入性头皮电极获得。通过标准心电图电极进行的一种经济有效的无创监测几乎可以用于每位患者,以代替超声波监测器。在这种方法中,许多电极被放置在母亲的腹部,同时收集各种信号的组合,包括母亲和胎儿的心跳。为了准确估计胎儿心率,必须从收集的混合物中提取干净的FECG。众所周知,这可以使用盲源分离(BSS)技术来实现。本文对基于Renyi互信息最小化的Mermaid算法的性能进行了评价,以解决这一具有重要实际意义的问题。利用人工混合的心电信号和真实心电混合的胎儿心率估计,说明了Mermaid算法的有效性和数据效率,以及它相对于其他信息理论BSS算法的优越性。
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引用次数: 41
Modulation transfer function and noise measurement using neural networks 调制传递函数与神经网络噪声测量
J. Delvit, D. Léger, S. Roques, C. Valorge
In the context of Earth observation satellites such as SPOT or IKONOS, it is important to measure the modulation transfer function (MTF) and the noise in order to quantify the quality of the imaging system. This measurement is useful to decide to focus the telescope or to make a deconvolution filter whose purpose is to enhance image contrast. This paper presents a univariant MTF and noise measurement method using non specific views. It is a particular application of a general approach of image quality assessment. The method presented in this paper is based on artificial neural network (ANN) use. The ANN learns how to recognize MTF and noise from known images, and the neural network is able, after the learning step, to assess the MTF and the noise from unknown images.
在SPOT或IKONOS等对地观测卫星中,为了量化成像系统的质量,测量调制传递函数(MTF)和噪声是很重要的。这一测量对于决定望远镜的焦距或制作反卷积滤波器以增强图像对比度是有用的。本文提出了一种基于非特定视图的无变MTF和噪声测量方法。它是一般图像质量评估方法的一个特殊应用。本文提出的方法是基于人工神经网络(ANN)的应用。人工神经网络学习如何从已知图像中识别MTF和噪声,并且神经网络能够在学习步骤之后评估未知图像中的MTF和噪声。
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引用次数: 3
期刊
2003 IEEE XIII Workshop on Neural Networks for Signal Processing (IEEE Cat. No.03TH8718)
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