Pub Date : 2024-07-01DOI: 10.22159/ijcr.2024v8i3.230
AL Akramullazi, Sabiha Sultana, F. Hossen, A. Asraf, Kudrat-E-Zahan
resistance is increasingly becoming a prominent global public health and developmental concern. The primary aim of this study is to synthesize metal complexes with superior antimicrobial properties. Methods: The Schiff base ligand (E)-N'-(1-thiophen-2-yl) ethylidene isonicotinohydrazide was synthesized by reacting isonicotinohydrazide (INH) with 2-acetylthiophene. This Schiff base was utilized to synthesize metal complexes with copper (II), nickel (II), and cobalt (II) ions via the reflux method. The ligand and metal complexes were characterized using various physicochemical techniques, including elemental analysis, conduct metric studies, magnetic susceptibility, FT‐IR, 1H NMR, ESI-MS, and electronic spectral analysis. Results: All complexes were successfully characterized. The Ni-complex demonstrated the highest cytotoxicity in the brine shrimp lethality bioassay compared to the Cu and Co-complexes. The Ni and Cu-complexes exhibited greater antibacterial efficacy against all bacteria, while the Co-complex showed no activity. Conclusion: The newly synthesized complexes proved to be highly stable, displaying significant antimicrobial potential. These findings suggest that future modifications to this synthesized series could address specific pharmaceutical needs.
耐药性正日益成为全球公共卫生和发展方面的一个突出问题。本研究的主要目的是合成具有优异抗菌性能的金属配合物：希夫碱配体 (E)-N'-(1-thiophen-2-yl) ethylidene isonicotinohydrazide 是通过异烟肼（INH）与 2-acetylthiophene 反应合成的。利用这种希夫碱，通过回流法合成了铜（II）、镍（II）和钴（II）离子的金属络合物。配体和金属配合物的表征采用了多种理化技术，包括元素分析、电导率研究、磁感应强度、傅立叶变换红外光谱、1H NMR、ESI-MS 和电子能谱分析：结果：所有复合物都成功地进行了表征。与铜和共络合物相比，镍络合物在盐水虾致死生物测定中表现出最高的细胞毒性。Ni 和 Cu 复合物对所有细菌都有较强的抗菌效果，而 Co 复合物则没有任何活性：结论：事实证明，新合成的复合物非常稳定，具有显著的抗菌潜力。这些研究结果表明，未来对这一合成系列的改良可以满足特定的制药需求。
{"title":"ISONICOTINOHYDRAZIDE DERIVED SCHIFF BASE–TRANSITION METAL COMPLEXES: STRUCTURE WITH BIOLOGICAL ACTIVITY","authors":"AL Akramullazi, Sabiha Sultana, F. Hossen, A. Asraf, Kudrat-E-Zahan","doi":"10.22159/ijcr.2024v8i3.230","DOIUrl":"https://doi.org/10.22159/ijcr.2024v8i3.230","url":null,"abstract":"resistance is increasingly becoming a prominent global public health and developmental concern. The primary aim of this study is to synthesize metal complexes with superior antimicrobial properties.\u0000Methods: The Schiff base ligand (E)-N'-(1-thiophen-2-yl) ethylidene isonicotinohydrazide was synthesized by reacting isonicotinohydrazide (INH) with 2-acetylthiophene. This Schiff base was utilized to synthesize metal complexes with copper (II), nickel (II), and cobalt (II) ions via the reflux method. The ligand and metal complexes were characterized using various physicochemical techniques, including elemental analysis, conduct metric studies, magnetic susceptibility, FT‐IR, 1H NMR, ESI-MS, and electronic spectral analysis.\u0000Results: All complexes were successfully characterized. The Ni-complex demonstrated the highest cytotoxicity in the brine shrimp lethality bioassay compared to the Cu and Co-complexes. The Ni and Cu-complexes exhibited greater antibacterial efficacy against all bacteria, while the Co-complex showed no activity.\u0000Conclusion: The newly synthesized complexes proved to be highly stable, displaying significant antimicrobial potential. These findings suggest that future modifications to this synthesized series could address specific pharmaceutical needs.","PeriodicalId":322389,"journal":{"name":"International Journal of Chemistry Research","volume":"13 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.22159/ijcr.2024v8i2.229
M. Balde, Adama Diedhiou, I. Ndoye, Harouna Tiréra, R. Gueye, Yoro Tine, Khadidiatou Thiam, Nango Gueye, M. Seck, D. Fall, A. Wélé
Methylene blue (MB) is a phenothiazine derivative used in microbiology, surgery, diagnostics and as a sensitizer in the photo-oxidation of organic pollutants. These numerous uses of methylene blue could lead to its accumulation in wastewater, causing harmful effects on the environment and living beings. To combat these harmful effects, numerous wastewater treatment processes, particularly physicochemical, were implemented. Adsorption techniques are particularly used to find new natural, biodegradable and inexpensive adsorbents to treat colored waste from structures such as medical and pharmaceutical laboratories. The aim of the present study was to carry out a relevant bibliographical review of the physico-chemical and thermodynamic parameters that can influence this adsorption of methylene blue on activated carbons of natural origin. The results showed a remarkable elimination of methylene blue. However, parameters such as particle size, adsorbent mass, pH, contact time, initial methylene blue concentration, agitation speed and temperature showed that the adsorption capacity of MB on biosorbents was influenced by these quantities. Similarly, the positive and negative enthalpy values (ΔH°) indicated that adsorption process could be endothermic or exothermic. Other thermodynamic parameters, such as the negative value of Gibbs free energy (ΔG°) and the positive value of entropy (ΔS°), also showed that the adsorption process was feasible and spontaneous.
{"title":"REVIEW OF THERMODYNAMIC AND PHYSICO-CHEMICAL PARAMETERS INFLUENCING METHYLENE BLUE ADSORPTION ON ACTIVATED CHARCOAL OF NATURAL ORIGIN","authors":"M. Balde, Adama Diedhiou, I. Ndoye, Harouna Tiréra, R. Gueye, Yoro Tine, Khadidiatou Thiam, Nango Gueye, M. Seck, D. Fall, A. Wélé","doi":"10.22159/ijcr.2024v8i2.229","DOIUrl":"https://doi.org/10.22159/ijcr.2024v8i2.229","url":null,"abstract":"Methylene blue (MB) is a phenothiazine derivative used in microbiology, surgery, diagnostics and as a sensitizer in the photo-oxidation of organic pollutants. These numerous uses of methylene blue could lead to its accumulation in wastewater, causing harmful effects on the environment and living beings. To combat these harmful effects, numerous wastewater treatment processes, particularly physicochemical, were implemented. Adsorption techniques are particularly used to find new natural, biodegradable and inexpensive adsorbents to treat colored waste from structures such as medical and pharmaceutical laboratories. The aim of the present study was to carry out a relevant bibliographical review of the physico-chemical and thermodynamic parameters that can influence this adsorption of methylene blue on activated carbons of natural origin. The results showed a remarkable elimination of methylene blue. However, parameters such as particle size, adsorbent mass, pH, contact time, initial methylene blue concentration, agitation speed and temperature showed that the adsorption capacity of MB on biosorbents was influenced by these quantities. Similarly, the positive and negative enthalpy values (ΔH°) indicated that adsorption process could be endothermic or exothermic. Other thermodynamic parameters, such as the negative value of Gibbs free energy (ΔG°) and the positive value of entropy (ΔS°), also showed that the adsorption process was feasible and spontaneous.","PeriodicalId":322389,"journal":{"name":"International Journal of Chemistry Research","volume":"63 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140794650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.22159/ijcr.2024v8i1.227
Timinibefi D. Zige, O. O. E.
Objective: To determine the microbial growth of Echerichia coli and Penicillium Italicum on polyethylene (PE) and screen for the activities of Manganese Peroxidase (MnP) and Laccase produced by the two microbial strain (Echerichia coli and Penicillium Italicum). Methods: Polyethylene (PE) used were obtained from Elizade university dumpsite Ilara-mokin, Ondo State. The polyethylene (PE) were cut into tiny pieces, rinsed with distilled water and then used as the sole carbon source for the growth of microorganisms in an orbital shaker flask. Laccase and manganese (Mnp) peroxidase activity were assayed in Escherichia coli and Penicillium italicum spectrophometrically as they utilize polyethylene (PE) as a carbon source. Results: Escherichia coli growth was at 0.002 at 0 h, rose to the exponential phase at 96 h, and declined to the death phase at 144 h. Penicillium italicum growth was at 0.004 at 0 h, rose to the exponential phase at 72 h, and declined to the death phase at 144 h. Laccase activity was 9.2 (U/ml) in Echerichia coli and manganese peroxidase (MnP)was 5.25 (U/ml) in Echerichia coli. Manganese peroxidase (MnP) was 10.643(U/ml) in Penicillium italicum while laccase activity was 9.5(U/ml) in Penicillium italicum. Conclusion: Echerichia coli and penicillium italicum showed Manganese peroxidase and Lacasse activities as they utilized polyethylene (PE) as carbon source. Hence, they should be explored for biodegradation of polyethylene (PE).
{"title":"SCREENING OF LACCASE AND MANGANESE PEROXIDASE ACTIVITIES PRODUCED BY ESCHERICHIA COLI AND PENICILLIUM ITALICUM ISOLATED FROM PLASTIC WASTE SITE IN AKURE, NIGERIA","authors":"Timinibefi D. Zige, O. O. E.","doi":"10.22159/ijcr.2024v8i1.227","DOIUrl":"https://doi.org/10.22159/ijcr.2024v8i1.227","url":null,"abstract":"Objective: To determine the microbial growth of Echerichia coli and Penicillium Italicum on polyethylene (PE) and screen for the activities of Manganese Peroxidase (MnP) and Laccase produced by the two microbial strain (Echerichia coli and Penicillium Italicum).\u0000Methods: Polyethylene (PE) used were obtained from Elizade university dumpsite Ilara-mokin, Ondo State. The polyethylene (PE) were cut into tiny pieces, rinsed with distilled water and then used as the sole carbon source for the growth of microorganisms in an orbital shaker flask. Laccase and manganese (Mnp) peroxidase activity were assayed in Escherichia coli and Penicillium italicum spectrophometrically as they utilize polyethylene (PE) as a carbon source.\u0000Results: Escherichia coli growth was at 0.002 at 0 h, rose to the exponential phase at 96 h, and declined to the death phase at 144 h. Penicillium italicum growth was at 0.004 at 0 h, rose to the exponential phase at 72 h, and declined to the death phase at 144 h. Laccase activity was 9.2 (U/ml) in Echerichia coli and manganese peroxidase (MnP)was 5.25 (U/ml) in Echerichia coli. Manganese peroxidase (MnP) was 10.643(U/ml) in Penicillium italicum while laccase activity was 9.5(U/ml) in Penicillium italicum.\u0000Conclusion: Echerichia coli and penicillium italicum showed Manganese peroxidase and Lacasse activities as they utilized polyethylene (PE) as carbon source. Hence, they should be explored for biodegradation of polyethylene (PE).","PeriodicalId":322389,"journal":{"name":"International Journal of Chemistry Research","volume":"13 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139455360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.22159/ijcr.2024v8i1.226
Shashank Tiwari, Kartikay Prakash
The computer modelling of structural complexes generated from two or more interacting molecules are referred to as molecular docking. It is an indispensable tool in computer-aided drug design and structural molecular biology. Using this technology, large libraries of compounds may be digitally screened, and the results can be graded along with structural assumptions about how the ligands impact the target's reduction. Recent advances in the synthesis of anti-infectious medicines prompted by structural insights have enabled the application of computer-assisted drug design in the quest for innovative mechanism-or structure-based drugs. Molecular docking is an important phase in the drug development process because it determines the best positions for molecules to occupy when they are coupled together and predicts how effectively two molecules will bind once they have been docked. The input structure's design is also critical, and the results are assessed using sampling methods and scoring systems. The recently developed docking software Local Move Monte Carlo provides a strong choice for customizable receptor docking strategies. Docking is a technique for determining how ligands and proteins interact. It is structurally sound and compatible with computer-assisted medication design. Successful docking discovers high-dimensional spaces and ranks function utilisation, resulting in a candidate docking rating that is acceptable. It may also be used to screen vast libraries of molecules and offer structural hypotheses for the process.
由两个或更多相互作用的分子产生的结构复合物的计算机建模被称为分子对接。它是计算机辅助药物设计和结构分子生物学中不可或缺的工具。利用这项技术，可以对大量化合物库进行数字筛选，并可根据配体如何影响靶标还原的结构假设对结果进行分级。最近，在结构洞察力的推动下，抗感染药物的合成取得了进展，这使得计算机辅助药物设计得以应用于寻求基于机制或结构的创新药物。分子对接是药物开发过程中的一个重要阶段，因为它能确定分子耦合在一起时的最佳位置，并预测两个分子对接后的结合效果。输入结构的设计也至关重要，其结果要通过采样方法和评分系统进行评估。最近开发的对接软件 Local Move Monte Carlo 为定制受体对接策略提供了有力的选择。对接是一种确定配体和蛋白质如何相互作用的技术。它结构合理，与计算机辅助药物设计兼容。成功的对接可以发现高维空间并对功能利用率进行排序，从而得出可接受的候选对接等级。它还可用于筛选庞大的分子库，并为这一过程提供结构假设。
{"title":"UNREVEALING THE COMPLEX INTERPLAY: MOLECULAR DOCKING: A COMPREHENSIVE REVIEW ON CURRENT SCENARIO, UPCOMING DIFFICULTIES, FORTHCOMING INITIATIVES, AND VIEWPOINTS","authors":"Shashank Tiwari, Kartikay Prakash","doi":"10.22159/ijcr.2024v8i1.226","DOIUrl":"https://doi.org/10.22159/ijcr.2024v8i1.226","url":null,"abstract":"The computer modelling of structural complexes generated from two or more interacting molecules are referred to as molecular docking. It is an indispensable tool in computer-aided drug design and structural molecular biology. Using this technology, large libraries of compounds may be digitally screened, and the results can be graded along with structural assumptions about how the ligands impact the target's reduction. Recent advances in the synthesis of anti-infectious medicines prompted by structural insights have enabled the application of computer-assisted drug design in the quest for innovative mechanism-or structure-based drugs. Molecular docking is an important phase in the drug development process because it determines the best positions for molecules to occupy when they are coupled together and predicts how effectively two molecules will bind once they have been docked. The input structure's design is also critical, and the results are assessed using sampling methods and scoring systems. The recently developed docking software Local Move Monte Carlo provides a strong choice for customizable receptor docking strategies. Docking is a technique for determining how ligands and proteins interact. It is structurally sound and compatible with computer-assisted medication design. Successful docking discovers high-dimensional spaces and ranks function utilisation, resulting in a candidate docking rating that is acceptable. It may also be used to screen vast libraries of molecules and offer structural hypotheses for the process.","PeriodicalId":322389,"journal":{"name":"International Journal of Chemistry Research","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139457100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.22159/ijcr.2023v7i4.224
SAMUEL J. BUNU, DORATHY GEORGE, DEGHINMOTEI ALFRED-UGBENBO, BENJAMIN U. EBESHI
Objective: The study aimed to quantify the concentrations and carcinogenic-related health risks assessment of some heavy metals in selected energy drinks frequently utilized in Bayelsa State, Nigeria. Methods: Eleven energy drinks samples were purchased from the general markets in Amassoma and Yenagoa, Bayelsa State, Nigeria, and were labeled D1–D11. The samples were digested using 10 ml of nitric acid at 120-150 ℃, and 2 ml of Perchloric acid was added after attaining room temperature, it was digested further until a clear solution was obtained, then made up to 25 ml with distilled water. The concentration of lead, cadmium, iron, and zinc were determined and quantified using Atomic Absorption Spectrophotometry (AAS), and the health-associated risks of these metals were evaluated using the standard Target Health Quotient (THQ). Results: The EDI (Estimated Daily Intake) of lead (Pd), Cadmium (Cd), iron (Fe), and zinc (Zn) was 0.130, 0.001, 0.726, and 0.193 mg/l, respectively, all were within the World Health Organization (WHO)-acceptable range. The Chronic Daily Intake (CDI) of Pd, Cd, Fe, and Zn was obtained as 0.001 to 0.010, 5.7 x 10-5, 0.001 to 0.050, and 0.0001 to 0.010 mg/l respectively. Conclusion: THQ for all metals analyzed was<1, the WHO acceptable limit. All the heavy metals were within acceptable THQ limits, thus posing no carcinogenic health potential risks on long-term consumption.
{"title":"HEAVY METALS QUANTIFICATION AND CORRELATIVE CARCINOGENIC-RISKS EVALUATION IN SELECTED ENERGY DRINKS SOLD IN BAYELSA STATE USING ATOMIC ABSORPTION SPECTROSCOPIC TECHNIQUE","authors":"SAMUEL J. BUNU, DORATHY GEORGE, DEGHINMOTEI ALFRED-UGBENBO, BENJAMIN U. EBESHI","doi":"10.22159/ijcr.2023v7i4.224","DOIUrl":"https://doi.org/10.22159/ijcr.2023v7i4.224","url":null,"abstract":"Objective: The study aimed to quantify the concentrations and carcinogenic-related health risks assessment of some heavy metals in selected energy drinks frequently utilized in Bayelsa State, Nigeria. Methods: Eleven energy drinks samples were purchased from the general markets in Amassoma and Yenagoa, Bayelsa State, Nigeria, and were labeled D1–D11. The samples were digested using 10 ml of nitric acid at 120-150 ℃, and 2 ml of Perchloric acid was added after attaining room temperature, it was digested further until a clear solution was obtained, then made up to 25 ml with distilled water. The concentration of lead, cadmium, iron, and zinc were determined and quantified using Atomic Absorption Spectrophotometry (AAS), and the health-associated risks of these metals were evaluated using the standard Target Health Quotient (THQ). Results: The EDI (Estimated Daily Intake) of lead (Pd), Cadmium (Cd), iron (Fe), and zinc (Zn) was 0.130, 0.001, 0.726, and 0.193 mg/l, respectively, all were within the World Health Organization (WHO)-acceptable range. The Chronic Daily Intake (CDI) of Pd, Cd, Fe, and Zn was obtained as 0.001 to 0.010, 5.7 x 10-5, 0.001 to 0.050, and 0.0001 to 0.010 mg/l respectively. Conclusion: THQ for all metals analyzed was<1, the WHO acceptable limit. All the heavy metals were within acceptable THQ limits, thus posing no carcinogenic health potential risks on long-term consumption.","PeriodicalId":322389,"journal":{"name":"International Journal of Chemistry Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134933952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.22159/ijcr.2023v7i4.225
OLALEYE TIMILEHIN F., OGUNBIYI OLUWAGBENGA J., JEMKUR MAURICE
Objective: This study investigates and assesses the potential of crushed, pulverized ceramics as a low-cost adsorbent for the removal of methyl orange from wastewater. The presence of heavy metals and dyes in water bodies are deadly to the living organisms inside water, in which these pollutants are bio-accumulated and biomagnified in the environment. Due to the health effects of these pollutants, it is, therefore, necessary to treat metal and dye-contaminated wastewater prior to its discharge into the environment in order to comply with the stringent environmental regulations and also safeguard the present and future generations. Methods: The influence of pH, contact time, initial metal concentration, adsorbent dosage and temperature were studied in batch experiments at room temperature and were measured using UV-VIS Spectrophotometer at wavelength 464 nm. Fourier Transform Infrared (FTIR) technique was employed as an instrument for characterization of the adsorbent before and after adsorption and the data were collected and interpreted using Microsoft Excel, 2016. Results: Maximum sorption for methyl orange was found to be at pH 2. The adsorption was rapid at the first 90 min of contact, with uptake of more than 90%, and equilibrium was achieved in 60 min of agitation. Langmuir, Freundlich and BET’s isotherm models were applied to describe the adsorption of methyl orange dye. Fourier Transform Infrared (FTIR) spectra of ceramics powder revealed that OH, C-H, C=C, C-O stretching were responsible for the adsorption. However, the effects of different experimental parameters that influenced the efficiencies of the adsorbent have been evaluated and optimized. Conclusion: The investigation revealed that the adsorption capacity of the powdered ceramics on the removal of methyl orange dye is high enough compared to observed values in literatures. Freundlich’s model fitted the equilibrium data better, while the pseudo-second-order kinetic model was the most fitting from the kinetic data obtained for the adsorption of methyl orange dye.
{"title":"ASSESSMENT OF THE EFFICIENCY OF CRUSHED CERAMICS IN ADSORBING METHYL ORANGE DYE FROM WASTEWATER","authors":"OLALEYE TIMILEHIN F., OGUNBIYI OLUWAGBENGA J., JEMKUR MAURICE","doi":"10.22159/ijcr.2023v7i4.225","DOIUrl":"https://doi.org/10.22159/ijcr.2023v7i4.225","url":null,"abstract":"Objective: This study investigates and assesses the potential of crushed, pulverized ceramics as a low-cost adsorbent for the removal of methyl orange from wastewater. The presence of heavy metals and dyes in water bodies are deadly to the living organisms inside water, in which these pollutants are bio-accumulated and biomagnified in the environment. Due to the health effects of these pollutants, it is, therefore, necessary to treat metal and dye-contaminated wastewater prior to its discharge into the environment in order to comply with the stringent environmental regulations and also safeguard the present and future generations. Methods: The influence of pH, contact time, initial metal concentration, adsorbent dosage and temperature were studied in batch experiments at room temperature and were measured using UV-VIS Spectrophotometer at wavelength 464 nm. Fourier Transform Infrared (FTIR) technique was employed as an instrument for characterization of the adsorbent before and after adsorption and the data were collected and interpreted using Microsoft Excel, 2016. Results: Maximum sorption for methyl orange was found to be at pH 2. The adsorption was rapid at the first 90 min of contact, with uptake of more than 90%, and equilibrium was achieved in 60 min of agitation. Langmuir, Freundlich and BET’s isotherm models were applied to describe the adsorption of methyl orange dye. Fourier Transform Infrared (FTIR) spectra of ceramics powder revealed that OH, C-H, C=C, C-O stretching were responsible for the adsorption. However, the effects of different experimental parameters that influenced the efficiencies of the adsorbent have been evaluated and optimized. Conclusion: The investigation revealed that the adsorption capacity of the powdered ceramics on the removal of methyl orange dye is high enough compared to observed values in literatures. Freundlich’s model fitted the equilibrium data better, while the pseudo-second-order kinetic model was the most fitting from the kinetic data obtained for the adsorption of methyl orange dye.","PeriodicalId":322389,"journal":{"name":"International Journal of Chemistry Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134934208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.22159/ijcr.2023v7i3.221
Edebi N Vaikosen, Samuel J. Bunu, E. Dode, Ruth B. Efidi
Objective: The study aimed to develop a simple, efficient, inexpensive, rapid, and reproducible spectrophotometric analytical technique for aminoglycosides analysis by condensing with ninhydrin reagent. Methods: At a pH of 8.0, different aminoglycosides, including amikacin, gentamycin, neomycin, and streptomycin, were deaminated by the ninhydrin reagent. The working standard solution for each component was accurately placed into a series of 10 ml calibrated volumetric flasks, then 1 ml of the ninhydrin reagent was added and heated in a water bath for 15 min. The wavelength(s) of maximum absorption(s) was recorded after scanning the resultant purple complex from 350 nm to 930 nm. The final working concentrations ranged between 1600 and 2000 ug/ml. Results: The average weight of a neomycin sulphate tablet was 0.747g, with a standard deviation of 0.667%. After complexing with ninhydrin reagent at pH 6.0 for 10 to 15 min, all aminoglycosides developed purple coloration that lasted beyond 24 h, compared to the initial white, pale yellow, and colorless appearance of streptomycin, amikacin, neomycin, and gentamycin, respectively. The scanned spectra of the purple complex of ninhydrin formed after reaction with aminoglycosides in the visible region (350-900 nm) were similar, indicating the presence of a common parent structural moiety. At 550 nm, 650 nm, 750 nm, and 850 nm, distinct absorptions were observed. Amikacin, Streptomycin, and Gentamicin had the highest absorbance between 800 and 900 nm. After the reaction with ninhydrin, three distinct absorbances were observed in the Neomycin spectrum: between 380 and 400 nm, 580 and 600 nm, and around 800 nm. The comparative spectra for the four aminoglycosides and ninhydrin reagent with blank show a unique feature for the compounds. The coefficients of regression were 0.996 and 0.995, respectively. Conclusion: The proposed methods for analyzing streptomycin in streptomycin injections were successful. The percentage purity ranged from 017–110 % at 650 and 850 nm, which corresponds to the British Pharmacopoeia (BP) limit that streptomycin sulphate tablets should be between 97.00 and 110%.
{"title":"SPECTROPHOTOMETRIC FINGERPRINTING AND CHEMICAL DETERMINATION OF STREPTOMYCIN, AMIKACIN, NEOMYCIN, AND GENTAMYCIN SULPHATE BY CONDENSING WITH NINHYDRIN REAGENT","authors":"Edebi N Vaikosen, Samuel J. Bunu, E. Dode, Ruth B. Efidi","doi":"10.22159/ijcr.2023v7i3.221","DOIUrl":"https://doi.org/10.22159/ijcr.2023v7i3.221","url":null,"abstract":"Objective: The study aimed to develop a simple, efficient, inexpensive, rapid, and reproducible spectrophotometric analytical technique for aminoglycosides analysis by condensing with ninhydrin reagent.\u0000Methods: At a pH of 8.0, different aminoglycosides, including amikacin, gentamycin, neomycin, and streptomycin, were deaminated by the ninhydrin reagent. The working standard solution for each component was accurately placed into a series of 10 ml calibrated volumetric flasks, then 1 ml of the ninhydrin reagent was added and heated in a water bath for 15 min. The wavelength(s) of maximum absorption(s) was recorded after scanning the resultant purple complex from 350 nm to 930 nm. The final working concentrations ranged between 1600 and 2000 ug/ml.\u0000Results: The average weight of a neomycin sulphate tablet was 0.747g, with a standard deviation of 0.667%. After complexing with ninhydrin reagent at pH 6.0 for 10 to 15 min, all aminoglycosides developed purple coloration that lasted beyond 24 h, compared to the initial white, pale yellow, and colorless appearance of streptomycin, amikacin, neomycin, and gentamycin, respectively. The scanned spectra of the purple complex of ninhydrin formed after reaction with aminoglycosides in the visible region (350-900 nm) were similar, indicating the presence of a common parent structural moiety. At 550 nm, 650 nm, 750 nm, and 850 nm, distinct absorptions were observed. Amikacin, Streptomycin, and Gentamicin had the highest absorbance between 800 and 900 nm. After the reaction with ninhydrin, three distinct absorbances were observed in the Neomycin spectrum: between 380 and 400 nm, 580 and 600 nm, and around 800 nm. The comparative spectra for the four aminoglycosides and ninhydrin reagent with blank show a unique feature for the compounds. The coefficients of regression were 0.996 and 0.995, respectively.\u0000Conclusion: The proposed methods for analyzing streptomycin in streptomycin injections were successful. The percentage purity ranged from 017–110 % at 650 and 850 nm, which corresponds to the British Pharmacopoeia (BP) limit that streptomycin sulphate tablets should be between 97.00 and 110%.","PeriodicalId":322389,"journal":{"name":"International Journal of Chemistry Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117241126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.22159/ijcr.2023v7i3.219
Amuda Mutiu Olasunkanmi, Oderinlo Ogunyemi
Objective: Persea americana is a popular plant that is well known for its fruit, which is highly consumed due to its nutritional and medicinal values. The rich secondary metabolites content of P. americana creates an opportunity to utilize it as a functional food or standardized herbal preparations. The quality of a medicinal plant is determined by the active substances produced by the plant. Therefore, the purpose of the present study is to determine the secondary metabolites present in P. americana grown in uncultivated farmland in Ogbomoso, Oyo State Nigeria. Methods: The dried pulvurised leaves of P. americana from uncultivated farmland in Ogbomoso, Oyo State Nigeria were extracted with methanol by the maceration method and partitioned successively with solvents of increasing polarity. The extracts obtained were subjected to phytochemical screening and the total phenolics were determined spectrometrically using the folin–ciocalteu method. Results: The phytochemical screening showed that P. americana is rich in various secondary metabolites such as flavonoids, saponins, tannins, and alkaloids. The total phenolic content gave 500µg/g gallic acid equivalent. The total flavonoid content obtained was 250µg/g using quercetin as standard. The anti-oxidant assay of the crude extract showed a high activity of 89.05% at a concentration of 0.05g/ml. Conclusion: Total phenolic content of the plant is likely to be a key for determining the free radical scavenging and ROS reducing ability of the plant.
{"title":"PHYTOCHEMICAL CONSTITUENTS AND ANTIOXIDANT ACTIVITY OF PERSEA AMERICANA LEAVE","authors":"Amuda Mutiu Olasunkanmi, Oderinlo Ogunyemi","doi":"10.22159/ijcr.2023v7i3.219","DOIUrl":"https://doi.org/10.22159/ijcr.2023v7i3.219","url":null,"abstract":"Objective: Persea americana is a popular plant that is well known for its fruit, which is highly consumed due to its nutritional and medicinal values. The rich secondary metabolites content of P. americana creates an opportunity to utilize it as a functional food or standardized herbal preparations. The quality of a medicinal plant is determined by the active substances produced by the plant. Therefore, the purpose of the present study is to determine the secondary metabolites present in P. americana grown in uncultivated farmland in Ogbomoso, Oyo State Nigeria.\u0000Methods: The dried pulvurised leaves of P. americana from uncultivated farmland in Ogbomoso, Oyo State Nigeria were extracted with methanol by the maceration method and partitioned successively with solvents of increasing polarity. The extracts obtained were subjected to phytochemical screening and the total phenolics were determined spectrometrically using the folin–ciocalteu method.\u0000Results: The phytochemical screening showed that P. americana is rich in various secondary metabolites such as flavonoids, saponins, tannins, and alkaloids. The total phenolic content gave 500µg/g gallic acid equivalent. The total flavonoid content obtained was 250µg/g using quercetin as standard. The anti-oxidant assay of the crude extract showed a high activity of 89.05% at a concentration of 0.05g/ml.\u0000Conclusion: Total phenolic content of the plant is likely to be a key for determining the free radical scavenging and ROS reducing ability of the plant.","PeriodicalId":322389,"journal":{"name":"International Journal of Chemistry Research","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129772627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.22159/ijcr.2023v7i2.216
R. R. Muneam, A. Abojassim, Ghadeer Hakim JAAFAR KATHEM
Objective: The purpose of this study was to look into the concentration of the heavy element Cadmium and its health risks in cheese samples available in Iraqi markets. Methods: 72 random samples of six country groups (15 Iran, 9 Iraq, 9 Egypt, 15 Turkey, 15 Hungary, and 9 Saudi Arabia) available in Iraqi markets were collected and analyzed using an atomic absorption spectrophotometer, Shimadzu model AA7000, USA. Results: The highest average Cd metal level in the samples was found in Iranian cheese, while the lowest was in Iraqi ones. The descending Cd order of the countries was Turkey>Hungary>Egypt>Iran>Saudi Arabia>Iraq, according to the T-test confirmation. The daily Cd metal intake ( ), Cd target hazard quotient ( ), and Cd carcinogenic risk ( ) values were less than the permissible and risk values. Conclusion: Eventually, the health risk parameters revealed that there are no pose risks from those cheeses to Iraqi consumers.
{"title":"HEAVY CADMIUM METAL DETERMINATION CONCENTRATION IN CHEESE","authors":"R. R. Muneam, A. Abojassim, Ghadeer Hakim JAAFAR KATHEM","doi":"10.22159/ijcr.2023v7i2.216","DOIUrl":"https://doi.org/10.22159/ijcr.2023v7i2.216","url":null,"abstract":"Objective: The purpose of this study was to look into the concentration of the heavy element Cadmium and its health risks in cheese samples available in Iraqi markets. \u0000Methods: 72 random samples of six country groups (15 Iran, 9 Iraq, 9 Egypt, 15 Turkey, 15 Hungary, and 9 Saudi Arabia) available in Iraqi markets were collected and analyzed using an atomic absorption spectrophotometer, Shimadzu model AA7000, USA.\u0000Results: The highest average Cd metal level in the samples was found in Iranian cheese, while the lowest was in Iraqi ones. The descending Cd order of the countries was Turkey>Hungary>Egypt>Iran>Saudi Arabia>Iraq, according to the T-test confirmation. The daily Cd metal intake ( ), Cd target hazard quotient ( ), and Cd carcinogenic risk ( ) values were less than the permissible and risk values.\u0000Conclusion: Eventually, the health risk parameters revealed that there are no pose risks from those cheeses to Iraqi consumers.","PeriodicalId":322389,"journal":{"name":"International Journal of Chemistry Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129864694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.22159/ijcr.2023v7i2.217
Edewor-kuponiyi Theresa Ibibia, B. T. A., O. D. V., M. A. I., A. M. O.
Objective: The main aim of this research is to determine the optimum conditions required for the synthesis of metal-flavonoid complexes from leaves of Jatropha curcus. Methods: Soxhlet extractor was used for the extraction. Phytochemical screening was carried out using the method described by Harborne. The phytochemical profile of the extract was determined using GC-MS. The flavonoid-metal complexes were synthesized using different transition metal salts and the methanolic plant leaves extract. The synthesis was carried out by varying the pH, metal ion and extract concentrations. The solubility of the flavonoid-metal complexes in different solvents was determined. The synthesized complexes were subjected to UV-visible and FTIR analysis. Results: Methanol extract gave a yield of 4. 88%. Phytochemical screening revealed the presence of Flavonoids, steroids and alkaloids. The GC-MS analysis showed the presence of 14 compounds. Maximum dry weights of complexes formed between 600-700 mg were obtained at a concentration of 1000 ppm crude extract and for the metal ion concentrations, the optimum concentration observed for Cd2+and Cu2+complexes was 120 ppm while that of Ni2+and Co2+complexes was 140 ppm. Most suitable pH for copper-flavonoid was 8, for cobalt-and cadmium-flavonoid complexes was 9 and pH of 10 for nickel-flavonoid complexes. The FTIR results showed the formation of the complex due to the shift observed in the band assigned to C=O The UV/visible spectrum showed absorbance in the wavelength range of 250-480 nm. Conclusion: Flavonoid-metal complexes were synthesized and their optimum conditions determine.
{"title":"GC-MS PROFILE, SYNTHESIS AND SPECTRAL CHARACTERIZATION OF FLAVONOID-METAL (CADMIUM, COBALT, COPPER, NICKEL) COMPLEXES OF JATROPHA CURCUS LEAVES","authors":"Edewor-kuponiyi Theresa Ibibia, B. T. A., O. D. V., M. A. I., A. M. O.","doi":"10.22159/ijcr.2023v7i2.217","DOIUrl":"https://doi.org/10.22159/ijcr.2023v7i2.217","url":null,"abstract":"Objective: The main aim of this research is to determine the optimum conditions required for the synthesis of metal-flavonoid complexes from leaves of Jatropha curcus.\u0000Methods: Soxhlet extractor was used for the extraction. Phytochemical screening was carried out using the method described by Harborne. The phytochemical profile of the extract was determined using GC-MS. The flavonoid-metal complexes were synthesized using different transition metal salts and the methanolic plant leaves extract. The synthesis was carried out by varying the pH, metal ion and extract concentrations. The solubility of the flavonoid-metal complexes in different solvents was determined. The synthesized complexes were subjected to UV-visible and FTIR analysis.\u0000Results: Methanol extract gave a yield of 4. 88%. Phytochemical screening revealed the presence of Flavonoids, steroids and alkaloids. The GC-MS analysis showed the presence of 14 compounds. Maximum dry weights of complexes formed between 600-700 mg were obtained at a concentration of 1000 ppm crude extract and for the metal ion concentrations, the optimum concentration observed for Cd2+and Cu2+complexes was 120 ppm while that of Ni2+and Co2+complexes was 140 ppm. Most suitable pH for copper-flavonoid was 8, for cobalt-and cadmium-flavonoid complexes was 9 and pH of 10 for nickel-flavonoid complexes. The FTIR results showed the formation of the complex due to the shift observed in the band assigned to C=O The UV/visible spectrum showed absorbance in the wavelength range of 250-480 nm.\u0000Conclusion: Flavonoid-metal complexes were synthesized and their optimum conditions determine.","PeriodicalId":322389,"journal":{"name":"International Journal of Chemistry Research","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122785252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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