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Comparison of efficacy of hepatitis B vaccination during induction versus maintenance phase of chemotherapy in acute lymphoblastic leukemia: A nonrandomized clinical trial 乙型肝炎疫苗在急性淋巴细胞白血病化疗诱导期和维持期的疗效比较:一项非随机临床试验
Pub Date : 2019-07-01 DOI: 10.4103/IJAMR.IJAMR_113_19
Gopisree Peringeth, P. Mohan, R. Dhodapkar, B. Dubashi, R. Swaminathan
Background: Acute lymphoblastic leukemia (ALL) patients are susceptible to hepatitis B infection due to profound immunosuppression and repeated transfusions. However, the comparative effectiveness of hepatitis B vaccination in different phases of chemotherapy has not been studied. Aim: In this comparative interventional study (CTRI/2017/08/009402), vaccination in the induction phase (IP) was compared to that in the maintenance phase (MP). Materials and Methods: The participating ALL patients in both groups (29 per group) were vaccinated with double the dose of hepatitis B vaccine at 0, 1, and 2 months. The proportion of patients with seroprotective anti-hepatitis B surface titers (>10 IU/ml) was compared between the two groups after each dose. Results: The seroprotection rates between both the phases were similar following the first (relative risk [RR] = 4, confidence interval [CI]: 0.47–33.65) and third (RR = 1.4, CI: 0.73-2.84) doses of vaccination, whereas following the second dose of vaccination, the seroprotection rate in IP was significantly higher than that of MP (RR = 1.9, CI: 1.07–3.35). Conclusion: This study concluded that a 0, 1, and 2 schedule of hepatitis B vaccination has similar efficacy in both the IP and the MP of chemotherapy in ALL patients. As the IP has a higher trend of seroprotection rates compared to MP, vaccination in IP followed by revaccination postchemotherapy may be preferred in countries with a high prevalence of hepatitis B infection.
背景:急性淋巴细胞白血病(ALL)患者由于严重的免疫抑制和反复输血,容易感染乙型肝炎。然而,乙型肝炎疫苗在不同化疗阶段的比较有效性尚未得到研究。目的:在这项比较介入研究(CTRI/2017/08/009402)中,将诱导期(IP)的疫苗接种与维持期(MP)的疫苗注射进行比较。材料和方法:两组(每组29例)的ALL患者在0、1和2个月时接种双倍剂量的乙型肝炎疫苗。比较两组在每次给药后血清保护性抗乙型肝炎表面滴度(>10IU/ml)的患者比例。结果:接种第一剂疫苗(相对风险[RR]=4,置信区间[CI]:0.47–33.65)和第三剂疫苗(RR=1.4,置信区间0.73-2.84)后,两个阶段的血清保护率相似,而接种第二剂疫苗后,IP的血清保护率显著高于MP(RR=1.9,CI:1.07-3.35)。结论:本研究得出结论,0、1和2方案的乙肝疫苗接种对ALL患者的IP和化疗MP具有相似的疗效。与MP相比,IP具有更高的血清保护率趋势,因此在乙型肝炎感染率高的国家,IP疫苗接种后再进行血液治疗可能是首选。
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引用次数: 0
Diagnostic accuracy of apex-pulse deficit for detecting atrial fibrillation 尖脉缺损对房颤诊断的准确性
Pub Date : 2019-07-01 DOI: 10.4103/IJAMR.IJAMR_48_19
Anjali Rajkumar, A. Bhattacharjee, R. Selvaraj
Background: Screening for asymptomatic atrial fibrillation (AF) can identify patients at risk of stroke and help initiate treatment. Apex-pulse deficit, the difference between apex beat rate and peripheral pulse rate, has been described as a clinical sign to identify AF. However, the accuracy of this measure to identify AF has not been studied before. Aims: The primary aim of this study was to determine the sensitivity and specificity of apex-pulse deficit more than 10, measured over 1 min, to identify AF using 12-lead electrocardiogram (ECG) as the gold standard. Methods: This was a prospective cross-sectional study. Subjects were those above 30 years of age with known AF (cases) or not in AF (controls). Apex-pulse deficit was measured in each of them and correlated with rhythm detected in 12-lead ECG. Results: A total of 70 patients were studied, 35 cases and 35 controls. Apex-pulse deficit was significantly larger for cases as compared to controls and was a good discriminant to identify AF. Receiver operating characteristic curve analysis showed an area under the curve of 0.86. With a cutoff of 10, sensitivity and specificity to identify AF were 62.8% and 85.7%, respectively. Using a cutoff of 5 increased the sensitivity to 80%. Counting over 30 s was significantly less accurate than counting over one full minute. Conclusion: Apex-pulse deficit is a low-cost method to identify AF and may be useful for screening. A cutoff of 5 may enhance the sensitivity of measurement as compared to the traditional cutoff of 10.
背景:无症状心房颤动(AF)的筛查可以识别有卒中风险的患者并帮助开始治疗。心尖脉差,即心尖搏动率与外周脉搏率之差,已被描述为识别房颤的临床体征。然而,这种识别房颤的方法的准确性此前尚未研究过。目的:本研究的主要目的是以12导联心电图(ECG)为金标准,确定在1分钟内测量的超过10的心尖脉冲缺损的敏感性和特异性。方法:前瞻性横断面研究。研究对象为30岁以上已知AF患者(病例)或无AF患者(对照组)。测量了每组患者的峰值脉冲缺陷,并与12导联心电图检测到的节律相关联。结果:共研究70例患者,其中病例35例,对照组35例。与对照组相比,病例的尖峰脉冲缺陷明显更大,这是识别AF的一个很好的鉴别指标。受试者工作特征曲线分析显示曲线下面积为0.86。截止值为10时,诊断AF的敏感性和特异性分别为62.8%和85.7%。使用5的截止值将灵敏度提高到80%。数超过30秒的时间比数超过一分钟的时间要准确得多。结论:峰脉亏缺是一种低成本的鉴别房颤的方法,可用于房颤的筛查。与传统的截止值10相比,5的截止值可以提高测量的灵敏度。
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引用次数: 3
Utilization of focused antenatal care service and associated factors among women in Southern Ethiopia 埃塞俄比亚南部妇女对重点产前保健服务的利用及其相关因素
Pub Date : 2019-07-01 DOI: 10.4103/IJAMR.IJAMR_53_19
A. Abera, N. Asseffa, Mohammed Obssa, Elazar Balla, M. Koyira
Introduction: Antenatal care is a medical service provided to women during pregnancy with the aim of improving the pregnancy outcome. The approach considers that every pregnancy has the potential to be complicated. Objective: This study aimed to assess the utilization and factors associated with attending focused antenatal care (FANC) service in Wolaita Zone, Southern Ethiopia. Materials and Methods: A community-based cross-sectional study was conducted among 551 women who gave birth in the last 2 years. In this study, multistage cluster sampling technique was employed to select primary and secondary sampling units. Univariate and multivariable logistic regressions were done to determine associated factors. P < 0.05 and 95% confidence interval were considered to declare statistical significance. Results: The mean age of the respondents was 26.4 ± 4.9 years. The overall utilization of FANC was 85%. Among 540 interviewed mothers, 243 (45%) followed four and above times antenatal care visits during their last pregnancy, whereas 297 (55%) mothers followed <4 times. Mother's educational status, travel time, knowledge of danger signs, plan for last pregnancy, and knowledge on starting FANC were associated with FANC utilization. Conclusion: The findings of this study showed low utilization of recommended FANC. Efforts to improve utilization of FANC must strengthen initiatives that promote pregnant mothers' awareness on benefits of antenatal care, promote pregnancy planning, and reduction of travel time to health facility.
前言:产前保健是在怀孕期间向妇女提供的一项医疗服务,目的是改善妊娠结局。该方法考虑到每次怀孕都有可能是复杂的。目的:本研究旨在评估埃塞俄比亚南部Wolaita区参加重点产前保健(FANC)服务的利用率和相关因素。材料和方法:以社区为基础的横断面研究对551名在过去2年内分娩的妇女进行了研究。在本研究中,采用多阶段整群抽样技术选择主要和次要抽样单位。通过单变量和多变量logistic回归来确定相关因素。P < 0.05, 95%置信区间为有统计学意义。结果:患者平均年龄26.4±4.9岁。FANC的总利用率为85%。在接受采访的540名母亲中,243名(45%)在上次怀孕期间进行了4次及以上的产前保健检查,而297名(55%)母亲的检查次数<4次。母亲的受教育程度、旅行时间、对危险标志的了解、上一次怀孕的计划和开始使用FANC的知识与FANC的使用有关。结论:本研究结果显示推荐的FANC使用率较低。为提高全面保健服务的利用率,必须加强各项举措,提高孕妇对产前保健益处的认识,促进怀孕计划,缩短前往保健设施的时间。
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引用次数: 4
The golden minute after birth – beyond resuscitation 出生后的黄金时刻——超越复苏
Pub Date : 2019-07-01 DOI: 10.4103/IJAMR.IJAMR_89_19
M. Girish, G. Subramaniam
In tackling the unconscionably high neonatal mortality rate much has been done, but much more remains to be done. The 1st minute after birth sets the foundation for the individual's future quality of life, and any intervention which facilitates the smooth transition from the cocooned fetal life to the independent adult life will quickly find worldwide acceptance. However, it is imperative that we also look for resource neutral interventions so that a neonate even in the most resource-challenged setting gets an opportunity to smile. The interventions we have elaborated upon in this article fall in this category. They are simple, easily applied in all settings, and are evidence-based.
在解决新生儿死亡率高得离谱的问题上,已经做了很多工作,但还有很多工作要做。出生后的第一分钟为个人未来的生活质量奠定了基础,任何有助于从封闭的胎儿生活平稳过渡到独立的成年生活的干预措施都将很快被世界接受。然而,我们也必须寻求资源中立的干预措施,这样即使在资源最困难的环境中,新生儿也有机会微笑。我们在这篇文章中阐述的干预措施属于这一类。它们简单,易于在所有环境中应用,并且是基于证据的。
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引用次数: 1
Massive gastric dilatation in outlet obstruction – is it always benign? 胃出口梗阻引起的胃扩张总是良性的吗?
Pub Date : 2019-01-01 DOI: 10.4103/IJAMR.IJAMR_126_19
J. Sejal, A. Pranavi, S. Mohsina, S. Sureshkumar, Debasis Naik, V. Kate
Gastric outlet obstruction is one of the most common clinical presentations of carcinoma of the stomach, especially in South-West Asia. Although gross gastric dilatation is common in benign obstruction of the pylorus due to peptic ulcer disease, a hugely dilated and distended stomach can be a very rare presentation in a patient with malignancy. A 65-year-old female patient presented with recurrent episodes of vomiting immediately after food, ball-rolling movements in the abdomen, and loss of appetite and significant weight loss in the past 1 month. Upper gastrointestinal endoscopy revealed a dilated stomach and an ulceroproliferative growth in the antropyloric region. A biopsy of the growth revealed moderately differentiated adenocarcinoma of the stomach. Contrast-enhanced computed tomography of the abdomen and pelvis showed proliferative growth at antrum and the hugely dilated stomach reaching up to the pelvis. The patient underwent exploratory laparotomy. Intraoperative findings were that of a dilated and thickened stomach with growth at the antropyloric region of the stomach. Metastatic omental deposits were also seen, and thus, palliative gastrojejunostomy was carried out. This case is being reported to highlight that occasionally malignant gastric outlet obstruction may lead to a massive dilatation of the stomach.
胃出口梗阻是胃癌最常见的临床表现之一,尤其是在西南亚地区。虽然胃扩张在消化性溃疡引起的幽门良性梗阻中是常见的,但在恶性肿瘤患者中,胃的巨大扩张和膨胀是非常罕见的。65岁女性患者,进食后立即呕吐,腹部滚球运动,食欲不振,体重明显减轻,过去1个月。上消化道内窥镜显示胃扩张和幽门区溃疡增生性生长。活检显示为中等分化的胃腺癌。腹部及骨盆电脑断层造影显示胃窦增生,胃扩张至骨盆。患者接受了剖腹探查术。术中发现胃扩张增厚,胃幽门区有生长。转移性网膜沉积也可见,因此,姑息性胃空肠吻合术进行。本病例报告强调,偶尔恶性胃出口梗阻可能导致胃的大量扩张。
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引用次数: 2
Outbreak investigation and containment measures of dengue fever in rural Wardha: A field epidemiological study 瓦尔达省农村登革热暴发调查及控制措施:现场流行病学研究
Pub Date : 2019-01-01 DOI: 10.4103/IJAMR.IJAMR_69_18
Sourav Goswami, Anupriya Jha, Sarinkumar Siven, A. Mundra, Subodh S. Gupta, D. Dambhare, A. Raut, A. Mehendale
Background: Dengue is a common vector-borne disease in countries like India, where it occurs in specific pockets including many in Maharashtra. During July–August 2018, an outbreak of dengue was suspected in a village of Wardha district, following an increase in the number of fever cases from the village, which demanded an urgent outbreak investigation to be carried out before it progressed into an epidemic/larger outbreak. Objectives: The aim of this study was to find out more cases, source of infection and to recommend necessary actions to control the dengue outbreak. Materials and Methods: This was a cross-sectional epidemiological study, where we used pre-tested, pre-designed epidemiological case sheets obtained from Integrated Disease Surveillance Program (IDSP). A case definition was proposed before beginning the investigation. Line listing, collection of blood samples, distribution of paracetamol tablets to fever cases, and making a spot map were some of the important steps carried out during the investigation. Results: Out of a total of 64 suspected fever cases, 36 cases fulfilled the case definition of dengue, set for the purpose of outbreak investigation. Twenty-three of them got admitted in different hospitals among whom two of them died. Apart from that, four of them were found to be positive for both dengue IgM and NS1 antigen in their blood samples. It was age group of 21–30 years which was mostly affected. Compared to males, the female population suffered more from the illness. House, container, and Breteau index were found to be 0.26, 0.09, and 0.32, respectively. Conclusion: Following the investigation, a detailed report was made, which was shared with the district health authority. The report also contained recommendations for necessary actions to be taken to control this outbreak and to further prevent such outbreaks in future.
背景:登革热在印度等国家是一种常见的媒介传播疾病,它发生在特定地区,包括马哈拉施特拉邦的许多地区。2018年7月至8月期间,在瓦尔达县的一个村庄出现发热病例数增加后,怀疑发生了登革热疫情,要求在疫情发展为流行病/更大规模疫情之前进行紧急疫情调查。目的:本研究的目的是发现更多的病例,感染来源,并建议必要的措施来控制登革热疫情。材料和方法:这是一项横断面流行病学研究,我们使用从综合疾病监测计划(IDSP)获得的预先测试、预先设计的流行病学病例表。在开始调查之前,提出了一个案例定义。列线、采集血样、向发热病例分发扑热息痛片和制作现场地图是调查过程中采取的一些重要步骤。结果:64例发热疑似病例中,符合登革热病例定义的有36例。其中23人被送往不同的医院,其中2人死亡。除此之外,其中4人的血液样本中登革热IgM和NS1抗原均呈阳性。以21 ~ 30岁人群影响最大。与男性相比,女性更容易患上这种疾病。House、container和Breteau指数分别为0.26、0.09和0.32。结论:在调查之后,编写了一份详细的报告,并与区卫生当局共享。该报告还载有为控制这次疫情和进一步防止今后发生此类疫情而应采取的必要行动的建议。
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引用次数: 2
Handling the transition: What is needed for effectively embracing competency-based undergraduate medical education? 处理过渡:有效地接受以能力为基础的本科医学教育需要什么?
Pub Date : 2019-01-01 DOI: 10.4103/IJAMR.IJAMR_16_19
V. Kumar, S. Rajasekhar
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引用次数: 0
Implementation of competency-based medical education for postgraduate courses in India 在印度研究生课程中实施以能力为基础的医学教育
Pub Date : 2019-01-01 DOI: 10.4103/IJAMR.IJAMR_25_19
S. Shrivastava, P. Shrivastava
IntRoductIon Competency‐based medical education (CBME) has been acknowledged as the need of the hour owing to the multiple benefits associated with it over traditional curriculum.[1] CBME is a learner‐driven process, with teachers serving the role of facilitator, and it allows a learner to acquire the desired skills at their own pace.[1] Competency refers to the habitual and judicious use of various attributes required to improve the health of an individual patient and the community. In general, competency is always more than one domain (viz., comprises knowledge, skills, and attitudes in varying combinations), whereas entrustable professional activities (EPAs) comprise more than one competencies.[1,2]
基于能力的医学教育(CBME)已经被认为是迫切需要的,因为它比传统课程有更多的好处CBME是一个学习者驱动的过程,教师扮演促进者的角色,它允许学习者按照自己的进度获得所需的技能能力是指习惯性和明智地使用各种属性,以改善个体患者和社区的健康。一般来说,能力总是不止一个领域(即,包括不同组合的知识、技能和态度),而可信赖的专业活动(EPAs)则包含不止一个能力。[1,2]
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引用次数: 0
Assessment of reliability and adaptation of fisher's 52-item self-directed learning readiness scale among medical students in Southern India fisher的52项自主学习准备量表在印度南部医学生中的可靠性和适应性评估
Pub Date : 2019-01-01 DOI: 10.4103/IJAMR.IJAMR_39_18
Sujiv Akkilagunta, S. Kar, K. Premarajan, S. Lakshminarayanan, A. Ramalingam, T. Chacko, S. Bhandary
Background: The concept of self-directedness is defined by the active participation of students in all phases of learning, from framing the learning objectives to the assessment process. Various scales have been developed to measure self-directed learning (SDL) among students. Fishers' SDL readiness scale (SDLRS) was validated among nursing students. The present study assessed the reliability of Fisher's SDLRS among medical students in India. Factor analysis was carried out to reduce the total number of items in the scale. Materials and Methods: The SDLRS used in the study consisted of 52 items classified under three domains. The scale was administered to a sample of 367 medical students between the first and seventh semesters. Cronbach's alpha was used to measure the reliability of the scale. For item-reduction and further abridgment, factor analysis was done using principal component analysis. Results: Cronbach's alpha was found to be 0.93 for Fisher's 52-item scale. Satisfactory reliability was observed across each domain (≥0.7). Factor analysis enabled the reduction of scale to 29 items with three domains. Conclusion: Fisher's 52-item SDLRS is a reliable scale for use among medical students in India. We propose the use of a reliable and shortened 29-item scale.
背景:自我指导的概念是指学生积极参与学习的各个阶段,从制定学习目标到评估过程。各种各样的量表被用来衡量学生的自主学习。fisher的SDL准备度量表(SDLRS)在护生中被验证。本研究评估Fisher's SDLRS在印度医学生中的可靠性。进行因子分析以减少量表的总条目数。材料和方法:研究中使用的SDLRS包括52个项目,分为三个领域。该量表在第一学期至第七学期期间对367名医科学生进行了抽样调查。采用Cronbach’s alpha来衡量量表的信度。为了减少项目和进一步删节,因子分析采用主成分分析。结果:Fisher 52题量表的Cronbach's alpha值为0.93。在各个领域均观察到令人满意的信度(≥0.7)。因子分析使量表减少到29个项目与三个领域。结论:Fisher的52项SDLRS量表在印度医学生中是一种可靠的量表。我们建议使用可靠且缩短的29项量表。
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引用次数: 2
Time-motion study of auxiliary nurse midwives of a primary health center from Wardha District of Maharashtra 马哈拉施特拉邦瓦尔达区初级保健中心辅助护士助产士的时间运动研究
Pub Date : 2019-01-01 DOI: 10.4103/IJAMR.IJAMR_50_18
Ishwari Bhombe, A. Raut, M. Taywade, P. Deshmukh
Introduction: In the rural health-care delivery system of India, auxiliary nurse midwife (ANM) is the key frontline field-level functionary who interacts directly with the community. A heavy responsibility of implementation of health programs rests on the shoulders of ANMs. As ANMs are central to the delivery of services under the National Rural health Mission including supervision of the work done by the accredited social health activist, we thought it prudent to analyze their work pattern so that their efficiency could be improved upon. Objective: The objective was to study the workload and work pattern of ANMs and identify the causes for improving work efficiency of ANMs. Materials and Methods: This was an observational cross-sectional study conducted among four purposively chosen ANMs from a primary health center (PHC) in Central India using time-motion study as the tool. An ANM's work pattern and workload were studied by constructing 24-h recall. One ANM was followed for a week, similarly the other ANM for another week so that the activities of entire month were covered. To ensure quality, work schedules reported by the ANMs each day were cross-checked with the concerned supervisor or medical officer PHC. Results: A free-listing and pile-sorting exercise was performed with the ANMs, and the 41 activities reported by them were clubbed in to five major categories. It was found that on meeting day, meeting and record keeping were the most performed tasks, whereas other tasks were hardly performed. On the day of home visits, ANMs performed the disease-related activity for most of their time, and record keeping or supporting tasks were the second most performed activities. Majority of ANM's time spent over the week was on supporting tasks which were not directly related to their job profile. Conclusion: We conclude that clarity about job responsibilities of ANMs is lacking and available working time is not effectively utilized. Time spent on supporting tasks such as travel and waiting is maximum. Training to manage time for priority tasks and to improve skills is required.
简介:在印度农村卫生保健提供系统中,辅助护士助产士(ANM)是直接与社区互动的关键一线现场级工作人员。执行卫生规划的重任落在了卫生主管部门的肩上。由于农村护士是国家农村保健特派团提供服务的核心,包括监督经认可的社会保健活动家所做的工作,我们认为分析他们的工作模式是谨慎的,以便提高他们的效率。目的:研究护士的工作量和工作模式,找出提高护士工作效率的原因。材料和方法:这是一项观察性横断面研究,在印度中部的一家初级卫生中心(PHC)中故意选择了四名ams,使用时间运动研究作为工具。通过构建24小时回忆来研究ANM的工作模式和工作量。一个ANM被跟踪了一个星期,同样地,另一个ANM也被跟踪了一个星期,这样整个月的活动都被覆盖了。为确保质量,每日由助理护士报告的工作时间表与有关主管或初级保健医务官进行交叉核对。结果:对ANMs进行了自由清单和堆分类练习,并将他们报告的41项活动分为五大类。结果发现,在会议当天,会议和记录是完成最多的任务,而其他任务几乎没有完成。在家访当天,护士大部分时间都在进行与疾病相关的活动,记录保存或支持任务是第二多的活动。ANM在这一周的大部分时间都花在支持任务上,这些任务与他们的工作没有直接关系。结论:护士工作职责不明确,工作时间未得到有效利用。花在支持任务上的时间是最多的,比如旅行和等待。需要培训来管理优先任务的时间和提高技能。
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引用次数: 5
期刊
International Journal of Advanced Medical and Health Research
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