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The art and science of writing narrative reviews 叙事性评论写作的艺术和科学
Pub Date : 2022-07-01 DOI: 10.4103/ijamr.ijamr_234_22
Aneesh Basheer
In this age of evidence-based medicine, systematic reviews are considered the highest level of evidence. However, traditional narrative reviews continue to have an important role in medicine. While narrative reviews have inherent shortcomings in terms of nonstandardized literature search, potential bias in the appraisal of retrieved articles, and interpretation of findings, they serve as sources of quick up-to-date reference for specific areas of interest of readers. Well-conducted reviews could inform readers about gaps in existing literature and areas that need new primary research. Crafting a narrative review requires a blend of good scientific approach and the skillful art of presentation. This article aims to provide an overview of the need for narrative reviews and strategies to equip potential review authors complete an effective narrative review.
在这个循证医学的时代,系统评价被认为是最高级别的证据。然而,传统的叙述性评论在医学中仍然发挥着重要作用。虽然叙述性综述在非标准化文献检索方面存在固有的缺点,在评价检索文章时存在潜在的偏见,以及对研究结果的解释,但它们可以作为读者感兴趣的特定领域的快速最新参考来源。良好的评论可以让读者了解现有文献中的差距和需要新的主要研究的领域。撰写一篇叙述性评论需要良好的科学方法和娴熟的表达艺术的结合。本文旨在概述叙事评论的必要性和策略,使潜在的评论作者能够完成有效的叙事评论。
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引用次数: 0
Evaluation of inhaler technique and asthma control among children in a low-resource setting 低资源环境下儿童吸入器技术与哮喘控制的评价
Pub Date : 2022-07-01 DOI: 10.4103/ijamr.ijamr_20_22
H. Prasad, Sohini Ghosh, S. Das, R. Manasa
Background: Inhalation has become the preferred route of drug administration compared to oral medication in managing Asthma due to its direct delivery to the airways, thus producing a faster onset of action and fewer systemic side effects at lower doses than would be required for other routes of administration. Aims and Objectives: This study aimed to evaluate the inhaler technique among children with asthma and its association with the level of asthma control and to identify factors associated with improper use of inhaler devices. Materials and Methods: This is a prospective cross-sectional study conducted at the Department of Pediatrics at B. P Koirala Institute of Health Science, university teaching Hospital in Nepal. The children with asthma were asked to use their inhaler device as usual and inhalational technique was assessed using inhaler device assessment tool and control of asthma level was assessed using the Childhood Asthma Control Test score. Results: One hundred and three asthmatic children of the age range of 4–11 years were enrolled in the study. The mean age of surveyed children was 6.3 ± 2.2 years and over half of the participants were boys (68.9%). Around 60% had moderate asthma. Among them, 50% had symptoms for <3 years; only 50% of children with asthma demonstrated good technique of inhaler medication. Forty-five percent of them showed optimal asthma control. Near about a quarter of the participants showed mistakes in one step and about a fifth of the children showed mistakes at more than one step. Almost 30% of children with asthma have not obtained inhaler technique education. Factors associated with poor inhaler technique and poor asthma control were younger age and irregular follow-ups. The most common errors in the proper use of inhalers were not shaking the inhaler before use (30%) and wrong breathing techniques (30%). Conclusions: Improper inhaler technique is common among children with asthma. Children with asthma should have their inhaler technique routinely checked, during visits and should be given detailed education on proper inhalation techniques. Health education programs on asthma control are recommended in countries like Nepal to improve proper asthma inhaler device use and treatment outcomes in children with asthma.
背景:在治疗哮喘方面,与口服药物相比,吸入已成为首选的给药途径,因为它可以直接输送到气道,因此在较低剂量下,比其他给药途径更快地起效,更少的全身副作用。目的和目的:本研究旨在评估哮喘儿童的吸入器技术及其与哮喘控制水平的关系,并确定与吸入器设备使用不当相关的因素。材料和方法:这是一项前瞻性横断面研究,在尼泊尔大学教学医院B.P Koirala健康科学研究所儿科进行。哮喘儿童被要求照常使用吸入器,使用吸入器评估工具评估吸入技术,并使用儿童哮喘控制测试评分评估哮喘水平的控制。结果:103名年龄在4-11岁之间的哮喘儿童参与了这项研究。受访儿童的平均年龄为6.3±2.2岁,超过一半的参与者是男孩(68.9%)。大约60%的儿童患有中度哮喘。其中50%的患者症状持续时间<3年;只有50%的哮喘儿童表现出良好的吸入器用药技术。其中45%的患者表现出最佳的哮喘控制。近四分之一的参与者在一步中出现错误,约五分之一的孩子在一步以上出现错误。近30%的哮喘儿童没有接受过吸入器技术教育。与吸入器技术差和哮喘控制差相关的因素是年龄较小和随访不规律。正确使用吸入器最常见的错误是在使用前没有摇晃吸入器(30%)和错误的呼吸技术(30%)。结论:不正确的吸入器技术在哮喘儿童中很常见。哮喘儿童在就诊期间应定期检查他们的吸入器技术,并应接受关于正确吸入技术的详细教育。建议尼泊尔等国开展哮喘控制健康教育项目,以改善哮喘儿童正确使用哮喘吸入器和治疗效果。
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引用次数: 0
Out-of-pocket expenditure for the diagnosis of cervical, breast, and oral cavity cancer: A cross-sectional study from a tertiary care hospital in South India 诊断宫颈癌、乳腺癌和口腔癌的自费支出:来自南印度一家三级护理医院的横断面研究
Pub Date : 2022-07-01 DOI: 10.4103/ijamr.ijamr_149_22
S. Singh, Mahalakshmy Thulasingam, B. Nagappa, Chitrita Singh, Vishnu Rajan, G. Karunanithi
Background: Cancer as a disease has widespread financial impact on patients. Most public funded government schemes provide insurance only after the diagnosis is made. Patients incur a substantial out-of-pocket expenditure even before the diagnosis. Objectives: The study was done with the objective of determining the total cost (direct out-of-pocket expenditure and indirect cost) incurred from the symptom onset to diagnosis among patients diagnosed with cancer of the uterine cervix, oral cavity, and breast. Materials and Methods: In this hospital-based study conducted in the Regional Cancer Center of a tertiary hospital in South India, 100 patients were interviewed using a predesigned, pretested questionnaire. For cost calculation, the reference period was duration between the first contact to the health facility for the symptoms suggestive of cancer, and the histopathological diagnosis. The total direct (out-of-pocket expenses) and indirect (income lost) costs were determined by interviewing the participants. The Mann-Whitney and Kruskal-Wallis test were used to compare the out-of-pocket expenses across age, gender, and tumor type categories. Results: The median (first quartile [Q1] and third quartile [Q3]) cost incurred while diagnosing the three cancers was Indian rupees (INRs) 3660 (1280, 12,660); the median (Q1, Q3) direct cost was INR 1710 (350, 10,930) and the median (Q1, Q3) indirect cost was INR 250 (0, 2000). Those who visited a private health facility for their symptoms incurred a significantly higher direct cost (P < 0.05). Further, those aged 15–44 years, above the poverty line, male, who had completed more than primary education, or were diagnosed with cervical cancer incurred higher costs, although this was not statistically significant. Conclusion: Patients of common cancers incur a high out-of-pocket expenditure even before initiation of treatment. Measures such as providing all diagnostic modalities under a single roof and adopting a standardized protocol for various investigation procedures may help in reducing the costs incurred by patients.
背景:癌症作为一种疾病对患者有着广泛的经济影响。大多数公共资助的政府计划只有在确诊后才提供保险。甚至在诊断之前,患者就需要支付大量的自付费用。目的:本研究的目的是确定宫颈癌、口腔癌和乳腺癌患者从症状出现到诊断所发生的总成本(直接自付费用和间接成本)。材料和方法:在南印度一家三级医院的区域癌症中心进行的这项以医院为基础的研究中,使用预先设计、预先测试的问卷对100名患者进行了访谈。在成本计算方面,参照期是第一次接触卫生机构发现癌症症状到组织病理学诊断之间的时间。总直接(自付费用)和间接(收入损失)成本是通过采访参与者来确定的。使用Mann-Whitney和Kruskal-Wallis测试来比较不同年龄、性别和肿瘤类型类别的自付费用。结果:诊断三种癌症的中位数(第一四分位数[Q1]和第三四分位数[Q3])费用为印度卢比(INRs) 3660 (1280, 12660);直接成本中位数(第一季度,第三季度)为1710卢比(350,10,930),间接成本中位数(第一季度,第三季度)为250卢比(0,2000)。到私立医疗机构就诊的患者直接费用显著高于私立医疗机构(P < 0.05)。此外,15至44岁、贫穷线以上、男性、完成小学以上教育或被诊断患有子宫颈癌的人的费用较高,尽管这在统计上并不显著。结论:普通癌症患者甚至在开始治疗前就产生了高额的自付费用。诸如在一个屋檐下提供所有诊断方式和对各种调查程序采用标准化方案等措施可能有助于减少患者所承担的费用。
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引用次数: 0
Anatomy in a virtual small-group learning setting: A COVID revelation 虚拟小组学习环境中的解剖学:新冠病毒的启示
Pub Date : 2022-07-01 DOI: 10.4103/ijamr.ijamr_34_22
John Mathew, P. Daniel, P. Shanthi, S. Srivatsava, A. Charles, Jenny Jacob, M. Gowri, S. Rabi
Background: The benefits of small-group learning (SGL) in anatomy are well documented; however, the COVID-19 pandemic has seen the dynamics of SGL change in the online environment. In this study, we aimed to study the effects of the online platform and the content created on students' perception in the delivery of virtual SGL (VrSGL) in anatomy for 1-year medical students. Materials and Methods: VrSGL in anatomy was conducted for 6 weeks on Microsoft Teams as a meeting platform. Each group consisted of 10–12 1st-year medical students. Various aspects of VrSGL were analyzed with respect to technological factors, online content, online small-group teaching, and assessment modalities such as online viva, digital spotters, clinical cases, and short answer writing, through validated online feedback forms. Results: Of the 97 students (46 males and 51 females), 86% found the frequency of VrSGL optimal. There was a substantial positive correlation between connectivity issues and the quality of SGL. Majority of the students reported that VrSGL enabled them to learn anatomy well (72%), at their own pace (90%), and increased their accountability (85%). There was a significant positive correlation between the effectiveness of VrSGL sessions and quality of specimen demonstration videos (P < 0.001), assignments (P < 0.001), and online assessment (P < 0.001). A significant drawback of VrSGL was the lack of handling of cadaveric specimens as reported by 91% of the students. Conclusion: The most impactful factors on VrSGL were quality of specimen demonstration videos, frequency of the SGL sessions, assignments, and online assessment modalities.
背景:在解剖学中,小组学习(SGL)的好处是有案可查的;然而,2019冠状病毒病大流行使在线环境中的SGL动态发生了变化。在本研究中,我们旨在研究在线平台和创建的内容对学生在解剖学虚拟SGL (VrSGL)教学中的感知的影响。材料与方法:以Microsoft Teams为会议平台,进行为期6周的VrSGL解剖学研究。每组由10-12名一年级医学生组成。通过经过验证的在线反馈表,对VrSGL的技术因素、在线内容、在线小组教学以及在线viva、digital spotters、临床病例、简答题写作等评估方式等各方面进行分析。结果:97名学生(男46名,女51名)中,86%的人认为VrSGL的频率是最佳的。连接问题与SGL质量之间存在实质性的正相关关系。大多数学生报告说,VrSGL使他们能够很好地学习解剖学(72%),按照自己的节奏(90%),并增加了他们的责任(85%)。VrSGL会话的有效性与标本演示视频的质量(P < 0.001)、作业(P < 0.001)和在线评估(P < 0.001)之间存在显著的正相关。据91%的学生报告,VrSGL的一个显著缺点是缺乏对尸体标本的处理。结论:对VrSGL影响最大的因素是标本演示视频的质量、SGL课程的频率、作业和在线评估方式。
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引用次数: 0
Perils of injudicious use of alternate forms of medicine: Toxic encephalopathy in a neonate 不当使用替代药物的危险:新生儿中毒性脑病
Pub Date : 2022-07-01 DOI: 10.4103/2349-4220.360869
Tissa John, Femitha Pournami, A. Prithvi, A. Panackal, Jyothi Prabhakar, Naveen Jain
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引用次数: 0
Arboviruses in human disease: An Indian perspective 人类疾病中的虫媒病毒:印度人的观点
Pub Date : 2022-07-01 DOI: 10.4103/ijamr.ijamr_237_22
Lakshmi Shanmugam, M. Kumaresan, Ramit Kundu, A. Gunalan, R. Dhodapkar
There has been a dramatic increase in the frequency of arboviral disease epidemics among humans and domestic animals worldwide in recent decades. Some of these infections have also undergone significant geographical expansion owing to uncontrolled urbanization leading to changes in vector distribution and/or adaptation of the etiologic agent to more anthropophilic vectors. Arboviral infections such as chikungunya have re-emerged in certain parts of the world, such as India (where chikungunya re-emerged in 2006 after 32 years of quiescence). Existing surveillance systems for arboviral infections in developing countries face several issues, such as being dependent on reporting of loosely defined clinical syndromes and infrequent laboratory confirmation. The recent re-emergence of Zika virus infections and its complications in South America underscore the urgent need for advancements in scientific knowledge on the biology of the arboviral agents and their vectors, innovations concerning diagnostic technologies, vector control measures, and therapeutic approaches. India, a tropical country, harbors an abundance of arthropod vectors capable of hosting and propagating viral infections. These vectors can transmit infections within humans, animals and also across species. This review focuses on viral infections in humans transmitted by arthropod vectors.
近几十年来,全世界人类和家畜中虫媒病毒疾病流行的频率急剧增加。由于不受控制的城市化导致媒介分布的变化和/或病原体对更亲人类媒介的适应,其中一些感染也经历了显著的地理扩张。像基孔肯雅病毒这样的虫媒感染在世界某些地区重新出现,例如印度(在沉寂了32年后,基孔肯亚病毒于2006年再次出现)。发展中国家现有的虫媒病毒感染监测系统面临着几个问题,例如依赖于定义松散的临床综合征的报告和罕见的实验室确认。最近寨卡病毒感染及其并发症在南美洲再次出现,突显出迫切需要在虫媒病毒制剂及其载体的生物学科学知识、诊断技术创新、载体控制措施和治疗方法方面取得进展。印度是一个热带国家,拥有大量能够宿主和传播病毒感染的节肢动物媒介。这些媒介可以在人类、动物体内以及跨物种传播感染。这篇综述的重点是通过节肢动物媒介传播的人类病毒感染。
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引用次数: 0
Revisiting cultural and biological perspectives on depression and antidepressants 重新审视抑郁症和抗抑郁药的文化和生物学观点
Pub Date : 2022-07-01 DOI: 10.4103/ijamr.ijamr_250_22
V. Menon
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引用次数: 0
Chronic cough etiology within a tertiary care center: A retrospective chart review 三级医疗中心慢性咳嗽病因回顾性分析
Pub Date : 2022-07-01 DOI: 10.4103/ijamr.ijamr_133_22
K. Supapannachart, Amanda Fryd, Sandeep Shelly, Anjali Warrier, Andrew Tkaczuk, Jeanne L. Hatcher, Adviteeya N. Dixit, K. Van Nostrand, Anand S. Jain, A. Gillespie, M. Kalangara, A. Klein
Purpose: Chronic cough occurs in 12% of the population and is associated with significant morbidity and healthcare utilization. Little is known about chronic cough patients requiring referral to higher level care facilities; such knowledge may improve primary care physician chronic cough referral algorithms. Methods: A retrospective study was conducted on patients with primary complaints of chronic cough presenting to Emory Healthcare, Atlanta between 2009 and 2020. Data on socio-demographics, etiology, treatment, and health behavior were extracted from the electronic medical records of patients with chronic cough that had been seen by at least by 1 cough specialist at a tertiary care center. The Chi-square test and analysis of variance helped determine differences in socio-demographic variables between patients with different primary cough etiologies. Results: A total of 1152 patients met the inclusion criteria for this study. Common etiologies of chronic cough were found to be neurogenic (n = 196, 17%), gastroesophageal reflux disease (n = 114, 9.9%), asthma (n = 93, 8.1%), and chronic obstructive pulmonary disease (n = 80, 6.9%). A multifactorial etiology was found in 213 (18.5%) patients and 99 (8.6%) patients were still undergoing further work up. Significant differences in age, sex, race, smoking status, and chronic cough duration were noted based on the underlying etiology. Interestingly, although nonsignificant, patients with pulmonary etiologies tended to live in areas with higher poverty rates. Conclusion: The most common etiology was neurogenic cough, typically a diagnosis of exclusion that goes undiagnosed in primary care settings. Primary care physicians should have a low threshold for referral to otolaryngologists and academic institutions should consider establishing multidisciplinary cough clinics to facilitate work up and treatment.
目的:慢性咳嗽发生在12%的人口中,与显著的发病率和医疗保健利用率有关。人们对需要转诊到更高级别护理机构的慢性咳嗽患者知之甚少;这样的知识可以改进初级保健医生的慢性咳嗽转诊算法。方法:对2009年至2020年间在亚特兰大埃默里医疗中心就诊的慢性咳嗽原发性主诉患者进行回顾性研究。社会人口统计、病因、治疗和健康行为的数据是从三级护理中心至少有1名咳嗽专家看过的慢性咳嗽患者的电子医疗记录中提取的。卡方检验和方差分析有助于确定不同原发性咳嗽病因患者之间社会人口学变量的差异。结果:共有1152名患者符合本研究的纳入标准。慢性咳嗽的常见病因为神经源性(n=196,17%)、胃食管反流病(n=114,9.9%)、哮喘(n=93,8.1%)和慢性阻塞性肺病(n=80,6.9%)。213名(18.5%)患者发现了多因素病因,99名(8.6%)患者仍在接受进一步的检查。根据潜在病因,在年龄、性别、种族、吸烟状况和慢性咳嗽持续时间方面存在显著差异。有趣的是,尽管不显著,但肺部病因患者往往生活在贫困率较高的地区。结论:最常见的病因是神经源性咳嗽,通常是在初级保健环境中未诊断出的排除性诊断。初级保健医生转诊到耳鼻喉科医生的门槛应该很低,学术机构应该考虑建立多学科的咳嗽诊所,以方便检查和治疗。
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引用次数: 0
Comparison of Nutrition Risk Screening 2002 and Subjective Global Assessment for predicting postoperative complications among patients undergoing elective abdominal surgery 2002年营养风险筛查与主观整体评估预测择期腹部手术患者术后并发症的比较
Pub Date : 2022-07-01 DOI: 10.4103/ijamr.ijamr_239_22
V. Kate, Hemamalini Raghuraman, M. Kavyashree, Gurushankari Balakrishnan, T. Elamurugan, Gomathi Shankar, N. Nanda, Mahalakshmy Thulasingam
Introduction: Malnutrition leads to poor outcomes in surgical patients, leading to negative impact during the postoperative period. Nutrition Risk Screening (NRS) 2002 and Subjective Global Assessment (SGA) are novel tools to assess nutrition risk which have the potential to predict the postoperative complications in surgical patients. Aim: This study was carried out to determine the efficiency of the NRS 2002 and SGA in predicting postoperative complications. Materials and Methods: A prospective cohort study was conducted to assess the nutritional risk of patients aged 18 years and above who underwent elective abdominal surgery. NRS 2002 and SGA were used for nutritional screening. Univariate analysis was carried out to determine the relative risk (RR) of complications for each variable. Receiver operating characteristic (ROC) and area under curve (AUC) were plotted for NRS 2002 and SGA to identify the score for the former and grade for the latter that predicted complications postoperatively. The correlation of malnutrition with surgical outcomes was performed to determine their association. Results: A total of 320 patients were included in the study. Among the patients who underwent elective abdominal surgeries, 39.4% of the total number developed postoperative complications. The most prevalent were Grade 2 complications, which accounted for 69.1% of all such events. Postoperative complications were recorded in 75.5% of the patients identified as at risk by NRS 2002, with a RR of 5.3 (95% confidence interval [CI]: 3.7–7.6; P < 0.001). Complications were found among 68.3% of those who were malnourished by SGA, with a RR of 4.2 (95% CI: 3.0–6.0; P < 0.001). The ROC curve for NRS 2002 to determine the complications had an AUC of 0.80. A score of 3 was the optimal cutoff of NRS 2002 for predicting complications with a maximum sensitivity of 93.6%. Similarly, the ROC curve for SGA grades to determine complications had an AUC of 0.79. Grade B was the best cutoff, with a sensitivity of 77.0%. Conclusion: Patients with NRS 2002 scores higher than or equal to 3 and SGA Grades B and above had a higher incidence of postoperative complications in patients undergoing elective abdominal surgeries. Hence, NRS 2002 and SGA are reliable nutrition risk assessment tools for predicting postoperative outcomes.
导言:营养不良导致手术患者预后不良,对术后产生负面影响。营养风险筛查(NRS) 2002和主观整体评估(SGA)是评估营养风险的新工具,有可能预测手术患者的术后并发症。目的:本研究旨在探讨NRS 2002和SGA在预测术后并发症方面的有效性。材料与方法:一项前瞻性队列研究旨在评估18岁及以上择期腹部手术患者的营养风险。NRS 2002和SGA用于营养筛选。进行单因素分析以确定每个变量并发症的相对风险(RR)。绘制NRS 2002和SGA的受试者工作特征(ROC)和曲线下面积(AUC),确定前者的评分和后者的分级,预测术后并发症。研究了营养不良与手术结果的相关性,以确定两者之间的关系。结果:共纳入320例患者。择期腹部手术患者中,术后并发症发生率为39.4%。最常见的是2级并发症,占所有此类事件的69.1%。NRS 2002确定的高危患者中有75.5%出现术后并发症,RR为5.3(95%可信区间[CI]: 3.7-7.6;P < 0.001)。68.3%的SGA营养不良患者出现并发症,RR为4.2 (95% CI: 3.0-6.0;P < 0.001)。NRS 2002用于确定并发症的ROC曲线的AUC为0.80。NRS 2002预测并发症的最佳分值为3分,最大敏感性为93.6%。同样,用于确定并发症的SGA分级的ROC曲线的AUC为0.79。B级为最佳临界值,敏感性为77.0%。结论:NRS 2002评分≥3分,SGA分级为B级及以上的择期腹部手术患者术后并发症发生率较高。因此,NRS 2002和SGA是预测术后预后的可靠营养风险评估工具。
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引用次数: 1
Virchow-Robin space enlargement associated with borderline intelligence and behavioral problems in a young male 维丘-罗宾空间扩大与年轻男性的边缘性智力和行为问题有关
Pub Date : 2022-07-01 DOI: 10.4103/ijamr.ijamr_31_22
K. Lakshmi, P. Maheshwari, B. Menon, S. Chandra
A 22-year-old male presented with borderline intelligence, visual and auditory hallucinations, and an obsessive urge to bite. He was investigated for organic pathology in view of visual hallucinations and his magnetic resonance imaging study showed enlarged Virchow-Robin Space, which are fluid-filled spaces that surround small blood vessels and capillaries in the brain. He had no facial dysmorphic features or autistic features. Literature reports that this finding is associated with dementias in elderly, obsessions, and auditory hallucinations, but there is little data on its association with visual hallucinations, or intellectual impairment in the young. He responded well to a combination of medications and psychosocial approaches. Neuroimaging offers a noninvasive, reproducible method to better understand the clinical associations and accumulate evidence base in young patients presenting with intellectual impairment and behavioral problems.
一名22岁的男性表现为智力边缘,视觉和听觉幻觉,以及强烈的咬人冲动。由于视觉幻觉,他接受了器质性病理的调查,他的磁共振成像研究显示维尔肖-罗宾空间扩大,这是大脑中小血管和毛细血管周围充满液体的空间。他没有面部畸形或自闭特征。文献报道,这一发现与老年人的痴呆、强迫症和幻听有关,但很少有数据表明它与视觉幻觉或年轻人的智力障碍有关。他对药物治疗和心理治疗的结合反应良好。神经影像学提供了一种无创、可重复的方法,可以更好地了解表现为智力障碍和行为问题的年轻患者的临床关联,并积累证据基础。
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引用次数: 0
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International Journal of Advanced Medical and Health Research
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