Pub Date : 2025-11-15DOI: 10.1016/j.bjane.2025.844712
Wagner Nedel , Luis Valmor Portela
{"title":"Association between troponin and NT-proBNP levels, cytokines, and clinical outcomes in early sepsis response: a cohort study","authors":"Wagner Nedel , Luis Valmor Portela","doi":"10.1016/j.bjane.2025.844712","DOIUrl":"10.1016/j.bjane.2025.844712","url":null,"abstract":"","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"76 1","pages":"Article 844712"},"PeriodicalIF":1.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-07DOI: 10.1016/j.bjane.2025.844699
Julien Raft , Anne-Sophie Lamotte , Cécile Huin Schohn , Caroline Fritz , Philippe Richebé
Background
Single-injection Paravertebral Block (PVB) is commonly used for analgesia in major breast surgery; however, its sensory effectiveness may be variable. This study investigated whether intraoperative changes in the Analgesia Nociception Index (ANI) are associated with PVB effectiveness.
Methods
This prospective observational study included 100 women scheduled for total mastectomy. A single-injection PVB was performed preoperatively under ultrasound guidance at the T3 level. Sensory testing was performed from T1 to T10, but block effectiveness was evaluated in the surgical field (T2–T6). PVBs were classified as effective (complete loss of cold sensation in all T2‒T6 dermatomes) or incomplete (partial cold sensation in this range). ANI variations, intraoperative remifentanil consumption, postoperative pain scores, and morphine use were compared.
Results
Ninety-three patients were analyzed. PVB was effective in 75% and incomplete in 25%. The mean ANI variation was significantly greater in the effective group (+1.4 ± 10.3) compared to the incomplete group (-11.0 ± 7.1), with a mean difference of 12.4 (95% CI: 8.8 to 16.0; p < 0.0001). Remifentanil consumption was higher in the incomplete group (0.072 ± 0.018 µg.kg−1.min−1 vs. 0.054 ± 0.008 µg.kg−1.min−1), mean difference 0.018 (95% CI: 0.010 to 0.026; p < 0.0001). Pain score and morphine consumption were significantly higher for patients with incomplete PVB.
Conclusion
In this observational study, a significant decrease in ANI values following skin dissection was associated with incomplete PVB. Early ANI monitoring may help identify insufficient regional block during total mastectomy, thus guiding intraoperative analgesic adjustment to improve patient comfort.
背景：单次注射椎旁阻滞（PVB）是乳房大手术中常用的镇痛方法；然而，它的感官效果可能是可变的。本研究探讨术中镇痛伤害感觉指数（ANI）的变化是否与PVB的有效性相关。方法：这项前瞻性观察研究包括100名计划进行全乳切除术的妇女。术前在超声引导下在T3水平进行单次PVB注射。从T1到T10进行感觉测试，但在手术野（T2-T6）评估阻滞效果。pvb被分为有效（所有T2-T6皮节完全失去冷感觉）和不完全（在这个范围内部分失去冷感觉）。比较ANI变化、术中瑞芬太尼用量、术后疼痛评分和吗啡使用情况。结果：对93例患者进行分析。PVB有效率75%，不完全率25%。有效组的ANI平均值（+1.4±10.3）明显大于不完全组（-11.0±7.1），平均差异为12.4 （95% CI: 8.8 ~ 16.0; p < 0.0001）。不完全组瑞芬太尼消耗量更高（0.072±0.018µg.kg-1）。Min-1 vs. 0.054± 0.008µg.kg-1。min-1)，平均差异0.018 （95% CI: 0.010 ~ 0.026; p < 0.0001）。不完全性PVB患者的疼痛评分和吗啡用量均显著增高。结论：在这项观察性研究中，皮肤剥离后ANI值的显著下降与PVB不完全性有关。早期ANI监测有助于发现全乳切除术中区域阻滞不足，从而指导术中镇痛调整，提高患者舒适度。
{"title":"Analgesia nociception index as a tool to assess the effectiveness of paravertebral block in total mastectomy: a prospective cohort study","authors":"Julien Raft , Anne-Sophie Lamotte , Cécile Huin Schohn , Caroline Fritz , Philippe Richebé","doi":"10.1016/j.bjane.2025.844699","DOIUrl":"10.1016/j.bjane.2025.844699","url":null,"abstract":"<div><h3>Background</h3><div>Single-injection Paravertebral Block (PVB) is commonly used for analgesia in major breast surgery; however, its sensory effectiveness may be variable. This study investigated whether intraoperative changes in the Analgesia Nociception Index (ANI) are associated with PVB effectiveness.</div></div><div><h3>Methods</h3><div>This prospective observational study included 100 women scheduled for total mastectomy. A single-injection PVB was performed preoperatively under ultrasound guidance at the T3 level. Sensory testing was performed from T1 to T10, but block effectiveness was evaluated in the surgical field (T2–T6). PVBs were classified as effective (complete loss of cold sensation in all T2‒T6 dermatomes) or incomplete (partial cold sensation in this range). ANI variations, intraoperative remifentanil consumption, postoperative pain scores, and morphine use were compared.</div></div><div><h3>Results</h3><div>Ninety-three patients were analyzed. PVB was effective in 75% and incomplete in 25%. The mean ANI variation was significantly greater in the effective group (+1.4 ± 10.3) compared to the incomplete group (-11.0 ± 7.1), with a mean difference of 12.4 (95% CI: 8.8 to 16.0; p < 0.0001). Remifentanil consumption was higher in the incomplete group (0.072 ± 0.018 µg.kg<sup>−1</sup>.min<sup>−1</sup> vs. 0.054 ± 0.008 µg.kg<sup>−1</sup>.min<sup>−1</sup>), mean difference 0.018 (95% CI: 0.010 to 0.026; p < 0.0001). Pain score and morphine consumption were significantly higher for patients with incomplete PVB.</div></div><div><h3>Conclusion</h3><div>In this observational study, a significant decrease in ANI values following skin dissection was associated with incomplete PVB. Early ANI monitoring may help identify insufficient regional block during total mastectomy, thus guiding intraoperative analgesic adjustment to improve patient comfort.</div></div>","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"76 1","pages":"Article 844699"},"PeriodicalIF":1.9,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145483963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of preoperative clear carbohydrate beverage on emergence delirium in children – a randomized controlled trial","authors":"Karan Cheema , Aakriti Gupta , Ajay Singh , Preethy J. Mathew","doi":"10.1016/j.bjane.2025.844698","DOIUrl":"10.1016/j.bjane.2025.844698","url":null,"abstract":"","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"76 1","pages":"Article 844698"},"PeriodicalIF":1.9,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.bjane.2025.844691
Fabrício T. Mendonça, Marcus Alexandre B. de Aviz, Ana Paula S. Bezerra, Lucas G. Silva, Estefane E. Gaspar, Bárbara N. Terol, Lucianna R. e Silva, Liliana M. Andrade
Objectives
To compare Pectoserratus Plane Block (PSPB) and Erector Spinae Plane (ESP) block regarding perioperative opioid consumption and chronic pain risk among women undergoing elective mastectomy.
Methods
Single-blind (patients), randomized (1:1) trial. The primary outcome was the composite measure defined as the use of fentanyl intraoperatively or tramadol postoperatively. Secondary outcomes encompassed intraoperative hemodynamics, short (24h), medium (3 months) and long-term (6 months) postoperative pain intensity and complications.
Results
99 patients were randomized (50 in the PSPB group and 49 in the ESP block group). Of these, 93 patients had complete data for the primary outcome. Use of either fentanyl or tramadol was required for 20 of 47 patients (43%) in the PSPB group and 28 of 46 patients (61%) in the ESP block group (Relative Risk [RR] 0.70, 95% Confidence interval [95% CI] 0.47‒1.05, p = 0.09). PSPB-treated patients had a lower risk of tramadol (RR = 0.31, 95% CI 0.12-0.77, p = 0.01) and dipyrone (RR = 0.60, 95% CI 0.39‒0.92, p = 0.02) consumption than ESP block-treated patients. PSPB lowered chronic pain risk at 3 months (RR = 0.66, 95% CI 0.47‒0.92, p = 0.02), with lower scores for the Short-Form McGill Pain Questionnaire (Mean Difference [MD] -2.55, 95% CI -4.31 to -0.78, p = 0.005) and the Douleur Neuropathique 4 Questions questionnaire (MD = -1.08, 95% CI -2.05 to -0.11, p = 0.03). By 6 months, pain outcomes were statistically comparable between groups. Hemodynamic variables and complications were comparable between groups.
Conclusion
PSPB and ESP block resulted in similar overall opioid consumption among women undergoing mastectomy. However, PSPB was associated with lower postoperative tramadol consumption.
目的比较胸锯肌平面阻滞（PSPB）和竖棘平面阻滞（ESP）对择期乳房切除术妇女围手术期阿片类药物消耗和慢性疼痛风险的影响。方法单盲（患者）、随机（1:1）试验。主要终点是术中芬太尼或术后曲马多使用的综合指标。次要结果包括术中血流动力学、短期（24小时）、中期（3个月）和长期（6个月）术后疼痛强度和并发症。结果99例患者随机分组，其中PSPB组50例，ESP阻滞组49例。其中，93例患者具有完整的主要结局数据。PSPB组47例患者中有20例（43%）需要使用芬太尼或曲马多，ESP阻断组46例患者中有28例（61%）需要使用芬太尼或曲马多（相对危险度[RR] 0.70, 95%可信区间[95% CI] 0.47-1.05, p = 0.09）。pspb治疗组服用曲马多（RR = 0.31, 95% CI 0.12-0.77, p = 0.01）和双吡隆（RR = 0.60, 95% CI 0.39-0.92, p = 0.02）的风险低于ESP阻滞治疗组。PSPB降低了3个月时的慢性疼痛风险（RR = 0.66, 95% CI 0.47-0.92, p = 0.02），短形式McGill疼痛问卷（平均差异[MD] -2.55, 95% CI -4.31至-0.78,p = 0.005）和Douleur神经病变4个问题问卷（MD = -1.08, 95% CI -2.05至-0.11,p = 0.03）得分较低。6个月时，两组疼痛结果具有统计学上的可比性。两组间血流动力学变量和并发症具有可比性。结论pspb和ESP阻断导致乳房切除术妇女阿片类药物的总体消耗相似。然而，PSPB与术后曲马多用量降低有关。
{"title":"Efficacy of pectoserratus plane block versus erector spinae plane block on acute and chronic pain after mastectomy: randomized clinical trial","authors":"Fabrício T. Mendonça, Marcus Alexandre B. de Aviz, Ana Paula S. Bezerra, Lucas G. Silva, Estefane E. Gaspar, Bárbara N. Terol, Lucianna R. e Silva, Liliana M. Andrade","doi":"10.1016/j.bjane.2025.844691","DOIUrl":"10.1016/j.bjane.2025.844691","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare Pectoserratus Plane Block (PSPB) and Erector Spinae Plane (ESP) block regarding perioperative opioid consumption and chronic pain risk among women undergoing elective mastectomy.</div></div><div><h3>Methods</h3><div>Single-blind (patients), randomized (1:1) trial. The primary outcome was the composite measure defined as the use of fentanyl intraoperatively or tramadol postoperatively. Secondary outcomes encompassed intraoperative hemodynamics, short (24h), medium (3 months) and long-term (6 months) postoperative pain intensity and complications.</div></div><div><h3>Results</h3><div>99 patients were randomized (50 in the PSPB group and 49 in the ESP block group). Of these, 93 patients had complete data for the primary outcome. Use of either fentanyl or tramadol was required for 20 of 47 patients (43%) in the PSPB group and 28 of 46 patients (61%) in the ESP block group (Relative Risk [RR] 0.70, 95% Confidence interval [95% CI] 0.47‒1.05, p = 0.09). PSPB-treated patients had a lower risk of tramadol (RR = 0.31, 95% CI 0.12-0.77, p = 0.01) and dipyrone (RR = 0.60, 95% CI 0.39‒0.92, p = 0.02) consumption than ESP block-treated patients. PSPB lowered chronic pain risk at 3 months (RR = 0.66, 95% CI 0.47‒0.92, p = 0.02), with lower scores for the Short-Form McGill Pain Questionnaire (Mean Difference [MD] -2.55, 95% CI -4.31 to -0.78, p = 0.005) and the Douleur Neuropathique 4 Questions questionnaire (MD = -1.08, 95% CI -2.05 to -0.11, p = 0.03). By 6 months, pain outcomes were statistically comparable between groups. Hemodynamic variables and complications were comparable between groups.</div></div><div><h3>Conclusion</h3><div>PSPB and ESP block resulted in similar overall opioid consumption among women undergoing mastectomy. However, PSPB was associated with lower postoperative tramadol consumption.</div></div>","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"75 6","pages":"Article 844691"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.bjane.2025.844687
Noah Letofsky , Dana Archibald , Anthony M.-H. Ho , Lais Helena N. e Lima , Rodrigo M. e Lima , Vinicius C. Quintão , Fernando B. Cançado , Ricardo V. Carlos , Leopoldo M. da Silva , Fernando N. Bellicieri , Saullo Q. Silveira , Arvin Haghighat , Rachel Phelan , Glenio B. Mizubuti
Background
Deeply sedated children cannot provide feedback if an epidural needle traumatizes the Spinal Cord (SC). Knowing relevant structure depths may, therefore, improve safety. We aimed to determine the epidural margin of safety, i.e., distances from the Ligamentum Flavum (LF) and from the dura mater to the SC in pediatric patients measured (i) Perpendicular to the SC and (ii) Parallel to the spinous process (to approximate needle trajectory).
Methods
Retrospective review of pediatric (0‒12 years-old) T2-weighted sagittal MRI spine scans without spinal pathology. Three investigators independently measured distances from the ventral edge of the LF, and from the ventral edge of the dura mater to the SC at T5/T6, T9/T10, and L1/L2. All measurements were taken perpendicular to the SC and parallel to the angle of the spinous process of the inferior vertebra.
Results
111 MRI scans [52 females, 0.08‒12 (median 7) years-old] were analyzed. The conus medullaris was identified superior to the L1 vertebra in 47 scans, requiring L1/L2 measurement exclusion. When all ages were combined, the largest median (range) depth [dura-mater–SC = 4.87 (2.30‒10.30) mm, LF–SC = 8.10 (4.57‒12.53) mm, measured perpendicular to the SC; and dura-mater–SC = 8.20 (3.75‒19.57) mm; LF–SC = 13.40 (5.50‒39.77) mm, measured at the angle parallel to the inferior spinous process] was at T5/T6.
Conclusion
Our results suggest that the margin of safety (dura-mater–SC distance and LF–SC distance) for performing epidurals in children may be greatest at the mid-thoracic spinal region. The measured ranges were very wide. Further studies are warranted to validate these findings in pediatric patients with other relevant “epidural placement” positions.
{"title":"Retrospective review of spinal magnetic resonance images to determine the margin of safety for epidural analgesia in pediatric patients","authors":"Noah Letofsky , Dana Archibald , Anthony M.-H. Ho , Lais Helena N. e Lima , Rodrigo M. e Lima , Vinicius C. Quintão , Fernando B. Cançado , Ricardo V. Carlos , Leopoldo M. da Silva , Fernando N. Bellicieri , Saullo Q. Silveira , Arvin Haghighat , Rachel Phelan , Glenio B. Mizubuti","doi":"10.1016/j.bjane.2025.844687","DOIUrl":"10.1016/j.bjane.2025.844687","url":null,"abstract":"<div><h3>Background</h3><div>Deeply sedated children cannot provide feedback if an epidural needle traumatizes the Spinal Cord (SC). Knowing relevant structure depths may, therefore, improve safety. We aimed to determine the epidural margin of safety, i.e., distances from the Ligamentum Flavum (LF) and from the dura mater to the SC in pediatric patients measured (i) Perpendicular to the SC and (ii) Parallel to the spinous process (to approximate needle trajectory).</div></div><div><h3>Methods</h3><div>Retrospective review of pediatric (0‒12 years-old) T2-weighted sagittal MRI spine scans without spinal pathology. Three investigators independently measured distances from the ventral edge of the LF, and from the ventral edge of the dura mater to the SC at T5/T6, T9/T10, and L1/L2. All measurements were taken perpendicular to the SC and parallel to the angle of the spinous process of the inferior vertebra.</div></div><div><h3>Results</h3><div>111 MRI scans [52 females, 0.08‒12 (median 7) years-old] were analyzed. The conus medullaris was identified superior to the L1 vertebra in 47 scans, requiring L1/L2 measurement exclusion. When all ages were combined, the largest median (range) depth [dura-mater–SC = 4.87 (2.30‒10.30) mm, LF–SC = 8.10 (4.57‒12.53) mm, measured perpendicular to the SC; and dura-mater–SC = 8.20 (3.75‒19.57) mm; LF–SC = 13.40 (5.50‒39.77) mm, measured at the angle parallel to the inferior spinous process] was at T5/T6.</div></div><div><h3>Conclusion</h3><div>Our results suggest that the margin of safety (dura-mater–SC distance and LF–SC distance) for performing epidurals in children may be greatest at the mid-thoracic spinal region. The measured ranges were very wide. Further studies are warranted to validate these findings in pediatric patients with other relevant “epidural placement” positions.</div></div>","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"75 6","pages":"Article 844687"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145330858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.bjane.2025.844690
Katarzyna Prus , Jamel Ortoleva , Federico Bilotta
{"title":"Clinical application of CNS injury biomarkers in anesthesia and intensive care","authors":"Katarzyna Prus , Jamel Ortoleva , Federico Bilotta","doi":"10.1016/j.bjane.2025.844690","DOIUrl":"10.1016/j.bjane.2025.844690","url":null,"abstract":"","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"75 6","pages":"Article 844690"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.bjane.2025.844700
Camila Cavalcante Castro , Sandro Max C. Silva , Martha Moreira C. Castro , Durval Campos Kraychete , Carla Daltro
Introduction
Chronic pain greatly affects quality of life and, consequently, impacts the psychological state, a condition that needs to be addressed. A 30% reduction in pain intensity is clinically significant. The objective of this study was to describe the clinical and psychological aspects of individuals with chronic pain undergoing standard treatment.
Methods
Descriptive longitudinal study involving individuals with chronic pain undergoing treatment at the Pain Outpatient Clinic of the Federal University of Bahia, in Salvador, Bahia, between June 2016 and December 2017. The variables studied were pain intensity, quality of life, sleep disorders, stress level, and the presence of anxiety and depression symptoms. Descriptive statistics were performed, and Student's t-test, and Fisher's Chi-Square test were used to compare the groups.
Results
We studied 134 individuals with a mean (standard deviation) age of 50 (10) years, 89.6% of whom were female. There was an improvement in quality of life and sleep, anxiety and depressive symptoms, and 58.2% of patients showed a 30% reduction in pain intensity. Among the factors associated with pain reduction, having a partner was a significant factor (73.7% vs. 52.1%; p = 0.030). However, symptoms of anxiety (81.6% vs. 75.0%; p = 0.436), symptoms of depression (63.2% vs. 58.3%; p = 0.718), and stress (92.1% vs. 87.5%; p = 0.846) were not associated with pain reduction.
Conclusion
This study suggests that multidisciplinary treatment can reduce pain intensity in chronically affected patients, as most patients exhibited a clinically significant response, accompanied by global improvement.
慢性疼痛极大地影响生活质量，从而影响心理状态，这是一个需要解决的问题。疼痛强度降低30%具有临床意义。本研究的目的是描述慢性疼痛接受标准治疗的个体的临床和心理方面。方法：描述性纵向研究涉及2016年6月至2017年12月在巴伊亚州萨尔瓦多巴伊亚联邦大学疼痛门诊接受治疗的慢性疼痛患者。研究的变量包括疼痛强度、生活质量、睡眠障碍、压力水平以及焦虑和抑郁症状的存在。采用描述性统计，采用Student’st检验和Fisher’s卡方检验进行组间比较。结果：我们研究了134例平均（标准差）年龄为50（10）岁的个体，其中89.6%为女性。患者的生活质量、睡眠质量、焦虑和抑郁症状均有所改善，58.2%的患者疼痛强度减轻了30%。在与疼痛减轻相关的因素中，有伴侣是显著因素（73.7% vs. 52.1%; p = 0.030）。然而，焦虑症状（81.6% vs. 75.0%; p = 0.436）、抑郁症状（63.2% vs. 58.3%; p = 0.718）和压力（92.1% vs. 87.5%; p = 0.846）与疼痛减轻无关。结论：本研究表明，多学科治疗可以减轻慢性疼痛患者的疼痛强度，因为大多数患者表现出显著的临床反应，并伴有整体改善。
{"title":"Evolution of patients with chronic pain undergoing standard treatment: a prospective longitudinal follow-up study","authors":"Camila Cavalcante Castro , Sandro Max C. Silva , Martha Moreira C. Castro , Durval Campos Kraychete , Carla Daltro","doi":"10.1016/j.bjane.2025.844700","DOIUrl":"10.1016/j.bjane.2025.844700","url":null,"abstract":"<div><h3>Introduction</h3><div>Chronic pain greatly affects quality of life and, consequently, impacts the psychological state, a condition that needs to be addressed. A 30% reduction in pain intensity is clinically significant. The objective of this study was to describe the clinical and psychological aspects of individuals with chronic pain undergoing standard treatment.</div></div><div><h3>Methods</h3><div>Descriptive longitudinal study involving individuals with chronic pain undergoing treatment at the Pain Outpatient Clinic of the Federal University of Bahia, in Salvador, Bahia, between June 2016 and December 2017. The variables studied were pain intensity, quality of life, sleep disorders, stress level, and the presence of anxiety and depression symptoms. Descriptive statistics were performed, and Student's t-test, and Fisher's Chi-Square test were used to compare the groups.</div></div><div><h3>Results</h3><div>We studied 134 individuals with a mean (standard deviation) age of 50 (10) years, 89.6% of whom were female. There was an improvement in quality of life and sleep, anxiety and depressive symptoms, and 58.2% of patients showed a 30% reduction in pain intensity. Among the factors associated with pain reduction, having a partner was a significant factor (73.7% vs. 52.1%; p = 0.030). However, symptoms of anxiety (81.6% vs. 75.0%; p = 0.436), symptoms of depression (63.2% vs. 58.3%; p = 0.718), and stress (92.1% vs. 87.5%; p = 0.846) were not associated with pain reduction.</div></div><div><h3>Conclusion</h3><div>This study suggests that multidisciplinary treatment can reduce pain intensity in chronically affected patients, as most patients exhibited a clinically significant response, accompanied by global improvement.</div></div>","PeriodicalId":32356,"journal":{"name":"Brazilian Journal of Anesthesiology","volume":"76 1","pages":"Article 844700"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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