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Editorial: Innovations, advances, and challenges in precision radiation oncology physics 社论:精准放射肿瘤物理学的创新、进步与挑战
Q4 Medicine Pub Date : 2023-12-06 DOI: 10.1002/pro6.1216
Fada Guan, L. Bronk, Jinbo Yue, R. Mohan, Zhe Chen
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引用次数: 0
Red shell‐ high risk normal tissue in stereotactic radiosurgery 红色外壳--立体定向放射手术中的高风险正常组织
Q4 Medicine Pub Date : 2023-12-01 DOI: 10.1002/pro6.1218
Jun Yang, W. Qi, Lei Wang, Q. Lu, Liangfu Han, Brian Wang, W. Yan
Due to the ablative nature of high prescription in Stereotactic Radiosurgery or stereotactic body radiation therapy (SRS/SBRT), the normal tissue surrounding the CTV receives the dose higher than tissue's dose constraint. A concept of Red Shell is proposed to define and quantify these tissue damaged in SBRT, using biological equivalent dose (BED) concept. The combination of biological factors and physics factors, including serial and parallel organ, dose gradient, dose distribution and fractionations, are further discussed to interpret the clinical meaning of Red Shell. This concept can also help planner to improve the optimization in planning process.
由于立体定向放射手术或立体定向体放射治疗(SRS/SBRT)中高剂量处方的烧蚀性质,CTV 周围的正常组织接收的剂量高于组织的剂量约束。我们提出了 "红壳"(Red Shell)概念,利用生物当量剂量(BED)概念来定义和量化 SBRT 中受损的组织。进一步讨论了生物因素和物理因素的结合,包括串行和并行器官、剂量梯度、剂量分布和分馏,以解释红壳的临床意义。这一概念还能帮助计划者改进计划过程中的优化。
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引用次数: 0
Dual‐Energy CT in Breast Cancer: Current Applications and Future Outlooks 双能量 CT 在乳腺癌中的应用:当前应用与未来展望
Q4 Medicine Pub Date : 2023-12-01 DOI: 10.1002/pro6.1213
Shaolan Guo, Tianye Liu, Guobin Qu, Jian Xu, Qingzeng Liu, Qian Zhao, Zhao Bi, Wanhu Li, Jian Zhu
Breast cancer is the most prevalent cancerous tumor in women, characterized by different subtypes and varying responses to treatment. The continued evolution of breast cancer diagnosis and management has resulted in a transition from a one‐size‐fits‐all approach to a new era of personalized treatment plans. Therefore, it is essential to accurately identify the biological characteristics of breast tissue in order to minimize unnecessary biopsies of benign lesions and improve the overall clinical process, leading to reduced expenses and complications associated with invasive biopsy procedures. Challenges for future research include finding ways to predict the response of breast cancer patients to adjuvant systemic treatment.Dual‐energy CT (DECT) is a new imaging technology integrating functional imaging and molecular imaging. Over the past decade, DECT has gained relevancy, especially in oncological radiology. This article proposed a literature review of the application and research status of DECT in breast cancer treatment strategy determination and prognosis prediction.
乳腺癌是女性中最常见的恶性肿瘤,其特点是不同的亚型和对治疗的不同反应。乳腺癌诊断和管理的不断发展导致了从一刀切的方法到个性化治疗计划的新时代的过渡。因此,准确识别乳腺组织的生物学特征是至关重要的,以尽量减少不必要的良性病变活检,改善整体临床过程,从而减少与侵入性活检手术相关的费用和并发症。未来研究的挑战包括找到预测乳腺癌患者对辅助全身治疗反应的方法。双能CT (Dual - energy CT, DECT)是一种集功能成像和分子成像于一体的新型成像技术。在过去的十年中,DECT已经获得了相关性,特别是在肿瘤放射学中。本文就DECT在乳腺癌治疗策略确定及预后预测中的应用及研究现状进行文献综述。
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引用次数: 0
Chinese clinical practice guidelines for the prevention and treatment of radiation‐induced rectal injury 预防和治疗放射性直肠损伤的中国临床实践指南
Q4 Medicine Pub Date : 2023-12-01 DOI: 10.1002/pro6.1217
Hui Zhang, Zhen Zhang, Shuanghu Yuan
Although radiotherapy plays an important role in the treatment of cancer, it may have negative effects in some individuals. Rectal injury is a common adverse effect of abdominal and pelvic radiotherapy. This injury is caused by administering radiation to the abdomen. Appropriate treatment techniques can be determined if doctors have a better understanding of the incidence, risk factors, and clinical symptoms of radiation‐induced rectal injuries. Studies on the underlying pathophysiology of radiation‐induced rectal injury may aid in the development of effective treatment and prevention strategies. The implementation of efficient preventive measures can improve the quality of life of patients with cancer and make it easier for them to complete their treatment. Therefore, comprehensive and accurate assessments are crucial for developing holistic and individualized treatment plans for patients who have already developed symptoms, with early intervention being a priority.
尽管放射治疗在癌症治疗中发挥着重要作用,但它可能会对某些人产生负面影响。直肠损伤是腹部和盆腔放疗的常见不良反应。直肠损伤是腹部和盆腔放疗的常见不良反应,这种损伤是由腹部放疗引起的。如果医生能更好地了解放射治疗引起直肠损伤的发生率、风险因素和临床症状,就能确定适当的治疗技术。对辐射所致直肠损伤的病理生理学进行研究,有助于制定有效的治疗和预防策略。实施有效的预防措施可以提高癌症患者的生活质量,使他们更容易完成治疗。因此,全面准确的评估对于为已出现症状的患者制定整体和个性化的治疗方案至关重要,而早期干预则是重中之重。
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引用次数: 0
Comparison of Rapid Arc and Intensity Modulated Radiotherapy in a True Beam Linear Accelerator for 6 MV: Application of AAPM TG‐119 tests in treatment planning and quality assurance 在 6 MV 真光束直线加速器中比较快速弧形放疗和调强放疗:AAPM TG-119 测试在治疗计划和质量保证中的应用
Q4 Medicine Pub Date : 2023-11-29 DOI: 10.1002/pro6.1212
S. Roy, B. Sarkar, Anirudh Pradhan
We developed rapid arc (RA) and intensity‐modulated radiotherapy (IMRT) plans based on the American Association of Physicists in Medicine Task Group‐119 (AAPM TG‐119) proposals and compared the planning and quality assurance results.
我们根据美国医学物理学家协会任务组-119(AAPM TG-119)的建议制定了快速弧线(RA)和调强放射治疗(IMRT)计划,并对计划和质量保证结果进行了比较。
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引用次数: 0
Blockchain + Radiotherapy: The Scenarios of the 5G‐Enabled Smart Radiotherapy Era 区块链+放疗:5G 智能放疗时代的应用场景
Q4 Medicine Pub Date : 2023-11-29 DOI: 10.1002/pro6.1211
Jian Zhu, Jinming Yu
In cancer radiotherapy (RT), each step can be digitalized, from CT simulation, planning, dose verification, and image guidance to treatment delivery. Therefore, RT may be the most digitized discipline in the field of internal medicine. Then, questions arise. What potential development opportunities does the development of network transmission technologies, such as blockchain and 5G, provide to promote the progress of tumor RT? What will the future of smart RT (SART) look like? The purpose of this article is to introduce briefly the main characteristics of blockchain and 5G transmission technologies and share ideas to imagine the “tomorrow” of smart RT, hoping to provide a more accurate, safe, and comfortable RT experience for patients in the future.
在癌症放射治疗(RT)中,从 CT 模拟、计划、剂量验证、图像引导到治疗实施,每个步骤都可以实现数字化。因此,放射治疗可能是内科领域数字化程度最高的学科。那么,问题来了。区块链、5G 等网络传输技术的发展为推动肿瘤 RT 的进步提供了哪些潜在的发展机遇?未来的智能 RT(SART)会是什么样子?本文旨在简要介绍区块链和 5G 传输技术的主要特点,并分享对智能 RT "明天 "的畅想,希望在未来为患者提供更准确、安全、舒适的 RT 体验。
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引用次数: 0
Chinese Clinical Practice Guidelines for the Prevention and Treatment of Radiation‐induced Dermatitis 中国放射性皮炎防治临床实践指南
Q4 Medicine Pub Date : 2023-09-20 DOI: 10.1002/pro6.1210
Ming Fan, Mei Feng, Shuanghu Yuan
Abstract Acute radiation‐induced esophagitis is a common complication of radiotherapy for esophageal, lung, and other malignancies. Therefore, understanding the diagnosis, grading, risk factors, prevention, and treatment of radiation‐induced esophagitis is essential. Currently, there are few consensuses and guidelines on radiation‐induced esophagitis worldwide, mainly the American College of Gastroenterology (ACG) clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE) and the Digestive Endoscopy Society of Chinese Medical Association's “Guidelines for the Diagnosis and Treatment of Reflux Esophagitis.” However, no consensus or guidelines specifically addressing radiation‐induced esophagitis have been established. Efforts have been made to organize experts to draft Chinese consensus or guidelines, but the recommendations in these guidelines also vary owing to differences in expert backgrounds. The clinical practice guidelines presented herein were developed for the first time with the joint participation of Chinese radiotherapy experts. Drugs and methods with clinical significance were selected by reviewing and summarizing the prevention and treatment of radiation‐induced esophagitis and combining them with China's national conditions. After multiple rounds of discussion and revision, clinical practice guidelines were established in line with the needs of Chinese clinicians, providing useful clinical guidance for the prevention and treatment of radiation‐induced esophagitis.
急性放射诱导食管炎是放疗治疗食管、肺和其他恶性肿瘤的常见并发症。因此,了解放射性食管炎的诊断、分级、危险因素、预防和治疗是至关重要的。目前,世界范围内关于辐射性食管炎的共识和指南很少,主要是美国胃肠病学学会(ACG)的临床指南:食管嗜酸性粒细胞增多和嗜酸性粒细胞性食管炎(EoE)的循证诊断和治疗方法和中华医学会消化内镜学会的《反流性食管炎的诊断和治疗指南》。然而,目前还没有针对放射性诱导的食管炎的共识或指南。已经努力组织专家起草中国共识或指南,但这些指南中的建议也因专家背景的差异而有所不同。本文提出的临床实践指南是中国放疗专家首次共同参与制定的。通过对放射性食管炎防治的回顾和总结,结合中国国情,选择具有临床意义的药物和方法。经过多轮讨论和修订,建立了符合我国临床医生需要的临床实践指南,为放射性食管炎的预防和治疗提供了有益的临床指导。
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引用次数: 0
Chinese expert consensus on the application of pegylated recombinant human granulocyte colony‐stimulating factor during concurrent chemoradiotherapy (2023 edition) 聚乙二醇化重组人粒细胞集落刺激因子在同步放化疗中的应用中国专家共识(2023版)
Q4 Medicine Pub Date : 2023-09-01 DOI: 10.1002/pro6.1201
Jun Wang, Baosheng Li
Neutropenia is the most common hematological toxicity of concurrent chemoradiotherapy (CCRT), and leads to subsequent treatment delays and/or dose reductions. Neutropenia often advances to febrile neutropenia and serious infections, which can affect the prognosis and safety of patients. The reasonable prevention and management of neutropenia is vital for patients with malignancies undergoing CCRT. Pegylated recombinant human granulocyte colony‐stimulating factor (PEG‐rhG‐CSF), a long‐acting recombinant human granulocyte colony‐stimulating factor, can prevent and treat neutropenia in more convenient clinical settings. Based on relevant guidelines and the most recent clinical data, the Chinese Association for Therapeutic Radiation Oncologists, China Society for Radiation Oncology, and Chinese Association of Radiation Therapy have evaluated the safety and efficacy of PEG‐rhG‐CSF during CCRT, clearly defined the clinical pathway and route of administration for the prevention and treatment of neutropenia, and formed a Chinese expert consensus on PEG‐rhG‐CSF application during CCRT, with the goal of promoting the reasonable clinical use of this treatment.
嗜中性粒细胞减少症是并发放化疗(CCRT)最常见的血液学毒性,并导致随后的治疗延迟和/或剂量减少。中性粒细胞减少症通常发展为发热性中性粒细胞增多症和严重感染,这会影响患者的预后和安全性。合理预防和管理中性粒细胞减少症对接受CCRT的恶性肿瘤患者至关重要。聚乙二醇化重组人粒细胞集落刺激因子(PEG-rhG-CSF)是一种长效重组人粒细胞核集落刺激因素,可以在更方便的临床环境中预防和治疗中性粒细胞减少症。根据相关指南和最新临床数据,中国放射肿瘤治疗学会、中国放射肿瘤学会和中国放射治疗学会评估了PEG-rhG-CSF在CCRT期间的安全性和有效性,明确了预防和治疗中性粒细胞减少症的临床途径和给药途径,并就PEG-rhG-CSF在CCRT中的应用形成了中国专家共识,目的是促进该疗法的合理临床应用。
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引用次数: 0
Clinical outcomes and recurrence patterns of high‐intermediate‐risk and high‐risk early‐stage endometrial cancer treated with postoperative intracavitary brachytherapy 术后腔内近距离放射治疗高-中危和高危早期子宫内膜癌的临床结果和复发模式
Q4 Medicine Pub Date : 2023-09-01 DOI: 10.1002/pro6.1209
Zihan Yan, Kang Ren, Wenhui Wang, Ke Hu, Xiaorong Hou, Fuquan Zhang
Abstract Objective To investigate the clinical outcomes and recurrence patterns of high‐intermediate‐risk (HIR)‐ and high‐risk (HR) early‐stage endometrial cancer (EC) treated with postoperative intracavitary brachytherapy alone. Methods We included 152 patients with International Federation of Gynecology and Obstetrics (FIGO) stage I‐II endometrial cancer with HIR and HR factors who received vaginal brachytherapy alone after surgery in our center between April 2008 and December 2017. The irradiation area was the top and upper halves of the vagina. The reference point was defined as 0.5 cm below the vaginal mucosa. The radiation dose was 25–30 Gy 5–6 times. The Kaplan–Meier method was used to calculate the survival rate; differences were assessed using the log‐rank test, and univariate and multivariate prognostic analyses were performed using the Cox regression model. Result The median follow‐up was 49.2 months (range 3–132 months). The 5‐year overall survival (OS), disease‐free survival (DFS), locoregional failure‐free survival time (LRFS), and distant metastasis‐free survival (DMFS) rates were 93.2%, 83.4%, 87.9%, and 86.6%, respectively. Treatment failure occurred in 18 patients, locoregional recurrence in 11, and distant metastasis in 14 (four with locoregional recurrence). Distant metastasis is the main recurrence pattern in patients at HIR and HR. Univariate and multivariate analyses revealed that age was an independent prognostic factor for OS, DFS, DMFS, and LRFS. Conclusion The main recurrence pattern after adjuvant vaginal brachytherapy alone was distant metastasis in patients with HIR and HR early‐stage EC. Age at onset was an independent prognostic factor for survival. Vaginal brachytherapy alone is an acceptable treatment option for patients with HIR and HR early‐stage endometrial cancer.
摘要目的探讨术后单独腔内近距离放射治疗早期高-中危(HIR)和高风险(HR)子宫内膜癌(EC)的临床疗效和复发模式。方法:我们纳入了2008年4月至2017年12月在本中心接受阴道近距离放疗的152例伴有HIR和HR因素的国际妇产科学联合会(FIGO) I - II期子宫内膜癌患者。照射部位为阴道的上半部和上半部。参考点定义为阴道黏膜下0.5 cm。辐照剂量25 ~ 30 Gy, 5 ~ 6次。采用Kaplan-Meier法计算存活率;使用log‐rank检验评估差异,使用Cox回归模型进行单因素和多因素预后分析。结果中位随访时间为49.2个月(3 ~ 132个月)。5年总生存率(OS)、无病生存率(DFS)、局部无衰竭生存时间(LRFS)和无远处转移生存率(DMFS)分别为93.2%、83.4%、87.9%和86.6%。18例患者治疗失败,11例局部复发,14例远处转移(4例局部复发)。远处转移是HIR和HR患者的主要复发方式。单因素和多因素分析显示,年龄是OS、DFS、DMFS和LRFS的独立预后因素。结论单纯阴道辅助近距离放疗后HIR和HR早期EC的复发以远处转移为主。发病年龄是生存的独立预后因素。阴道近距离放疗是HIR和HR早期子宫内膜癌患者可接受的治疗选择。
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引用次数: 0
Chinese clinical practice guidelines for the prevention and treatment of radiation‐induced dermatitis 中国临床实践指南预防和治疗放射性皮炎
Q4 Medicine Pub Date : 2023-09-01 DOI: 10.1002/pro6.1208
Ming Fan, Mei Feng, Shuanghu Yuan
Abstract Radiation‐induced dermatitis is one of the most prevalent complications in patients undergoing cancer radiotherapy and poses a significant challenge to cancer therapy. The symptoms include erythema, dry desquamation, and moist desquamation, which are frequently observed in patients with breast, head and neck, anal, and vulvar cancers. Early skin reactions typically manifest within 2–4 weeks following the initiation of radiotherapy. In severe cases, acute dermatitis can cause radiotherapy interruptions, prolong treatment time, and ultimately affect patient outcomes and quality of life. Currently, there are numerous guidelines on radiation dermatitis, including the Multinational Association of Supportive Care in Cancer (MASCC), British Columbia Cancer Agency (BCCA), Oncology Nursing Society (ONS), and UK Society of Radiographers (SCoR) guidelines. In China, dermatology experts have drafted a consensus. However, due to the differing backgrounds of experts, recommendations among guidelines vary. These guidelines were first developed by Chinese radiation oncologists. The evidence‐based guideline in this paper fully considers and adopts China's national conditions; hence, it can be easily applied in daily practice.
放射性皮炎是癌症放疗患者最常见的并发症之一,对癌症治疗提出了重大挑战。其症状包括红斑、干性脱屑和湿性脱屑,常见于乳腺癌、头颈癌、肛门癌和外阴癌患者。早期皮肤反应通常在放射治疗开始后的2-4周内出现。在严重的情况下,急性皮炎可导致放疗中断,延长治疗时间,并最终影响患者的预后和生活质量。目前,有许多关于放射性皮炎的指南,包括多国癌症支持护理协会(MASCC)、不列颠哥伦比亚省癌症机构(BCCA)、肿瘤护理协会(ONS)和英国放射技师协会(SCoR)指南。在中国,皮肤科专家已经起草了一份共识。然而,由于专家的背景不同,指南中的建议也有所不同。这些指南最初是由中国放射肿瘤学家制定的。本文的循证指南充分考虑并采用了中国的国情;因此,它可以很容易地应用到日常实践中。
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引用次数: 0
期刊
Precision Radiation Oncology
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