Shubhescha Parab, U. Usgaonkar, V. Albal, Vathsalya Vijay
Fish-hook injuries are relatively uncommon and frequently involve upper extremities. A wide spectrum of ocular and adnexal trauma can occur following fish hook injury. We report an unusual presentation of ocular adnexal injury in a 34-year-old male who presented with a fish hook embedded in the lower eyelid margin with an intact anterior and posterior lamella. The fish hook was retrieved successfully without traumatizing both the lamellae by adopting a “sutureless, gray line split technique.” This case is being reported for its distinctive presentation and to emphasize the need to respect tissue anatomy and minimize surgical trauma while attempting removal of such sharp objects in order to achieve optimal functional and aesthetic outcomes.
{"title":"Fish hook injury to the eye: A unique presentation","authors":"Shubhescha Parab, U. Usgaonkar, V. Albal, Vathsalya Vijay","doi":"10.4103/kjo.kjo_220_21","DOIUrl":"https://doi.org/10.4103/kjo.kjo_220_21","url":null,"abstract":"Fish-hook injuries are relatively uncommon and frequently involve upper extremities. A wide spectrum of ocular and adnexal trauma can occur following fish hook injury. We report an unusual presentation of ocular adnexal injury in a 34-year-old male who presented with a fish hook embedded in the lower eyelid margin with an intact anterior and posterior lamella. The fish hook was retrieved successfully without traumatizing both the lamellae by adopting a “sutureless, gray line split technique.” This case is being reported for its distinctive presentation and to emphasize the need to respect tissue anatomy and minimize surgical trauma while attempting removal of such sharp objects in order to achieve optimal functional and aesthetic outcomes.","PeriodicalId":32483,"journal":{"name":"Kerala Journal of Ophthalmology","volume":"34 1","pages":"256 - 258"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48948667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The purpose of the study is to study the clinical features, causative organisms, and treatment outcome in cases of infectious scleritis. Design: This is a retrospective study. Materials and Methods: Medical and microbiological records of all patients diagnosed as infectious scleritis between January 2016 and December 2019 were reviewed. Information including age, sex, clinical features, predisposing factor, causative organism, and treatment outcome was extracted from records and analyzed. Results: A total of 12 cases of infectious scleritis were identified. Five (41.6%) cases had a prior history of trauma and 3 (25%) cases had undergone cataract surgery in the past. Redness with pain in the involved eye was the most common presenting complaint (91.6%, n = 11). Most of the cases (n = 11, 91.6%) presented with visible scleral abscess under slit-lamp examination. Fifty percent cases (n = 6) were caused due to fungal infection, most common species being Aspergillus (41.6%, n = 5). Pseudomonas aeruginosa (25%, n = 3) was the second most common causative organism. Microbe-specific medical treatment was given and scleral debridement done for all the eyes. Globe was preserved in 83.3% (n = 10) of the eyes. About 41.6% (n = 5) of eyes had best-corrected visual acuity 6/18 or better at the end of 3 months. Conclusion: Previous history of trauma should raise high suspicion regarding infectious etiology in any case of scleritis. In cases with no antecedent history, subtle clinical differences between autoimmune and infective scleritis, along with response to therapy, should be kept in mind to reach at a diagnosis. In tropical countries like India, fungi, most commonly Aspergillus flavus, are the most common organism responsible for infective scleritis. Along with medical treatment, surgical debridement plays a major role in the management of infective scleritis.
{"title":"Infectious scleritis: Clinical profile and treatment outcome in a tertiary eye care center in Southern India","authors":"Shivananda Narayana, Bidisha Mahapatra, Kunal Mandlik","doi":"10.4103/kjo.kjo_56_21","DOIUrl":"https://doi.org/10.4103/kjo.kjo_56_21","url":null,"abstract":"Purpose: The purpose of the study is to study the clinical features, causative organisms, and treatment outcome in cases of infectious scleritis. Design: This is a retrospective study. Materials and Methods: Medical and microbiological records of all patients diagnosed as infectious scleritis between January 2016 and December 2019 were reviewed. Information including age, sex, clinical features, predisposing factor, causative organism, and treatment outcome was extracted from records and analyzed. Results: A total of 12 cases of infectious scleritis were identified. Five (41.6%) cases had a prior history of trauma and 3 (25%) cases had undergone cataract surgery in the past. Redness with pain in the involved eye was the most common presenting complaint (91.6%, n = 11). Most of the cases (n = 11, 91.6%) presented with visible scleral abscess under slit-lamp examination. Fifty percent cases (n = 6) were caused due to fungal infection, most common species being Aspergillus (41.6%, n = 5). Pseudomonas aeruginosa (25%, n = 3) was the second most common causative organism. Microbe-specific medical treatment was given and scleral debridement done for all the eyes. Globe was preserved in 83.3% (n = 10) of the eyes. About 41.6% (n = 5) of eyes had best-corrected visual acuity 6/18 or better at the end of 3 months. Conclusion: Previous history of trauma should raise high suspicion regarding infectious etiology in any case of scleritis. In cases with no antecedent history, subtle clinical differences between autoimmune and infective scleritis, along with response to therapy, should be kept in mind to reach at a diagnosis. In tropical countries like India, fungi, most commonly Aspergillus flavus, are the most common organism responsible for infective scleritis. Along with medical treatment, surgical debridement plays a major role in the management of infective scleritis.","PeriodicalId":32483,"journal":{"name":"Kerala Journal of Ophthalmology","volume":"34 1","pages":"210 - 215"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43313328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Awareness about Eye Health in Kerala","authors":"Smita Narayan","doi":"10.4103/kjo.kjo_110_22","DOIUrl":"https://doi.org/10.4103/kjo.kjo_110_22","url":null,"abstract":"","PeriodicalId":32483,"journal":{"name":"Kerala Journal of Ophthalmology","volume":"72 1","pages":"193 - 194"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70823406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lakshmi Cherungottil, Muhemmed Swadique, A. Ravindran, M. Safarulla, Usha P. Rani
Purpose: Assessing efficacy of atropine 0.01% eye drops in retarding myopia progression in children, the feasibility of its use, and patient acceptance outside institutional practice. Design: Prospective observational hospital-based study was conducted in children who were prescribed aropine 0.01% eye drops to retard the progression of myopia. Methods: Fifty-seven children who showed a documented progression of ≥0.5 diopters (D) of myopia were prescribed atropine 0.01% eyedrops. In those patients who followed up, the mean change in spherical equivalent was assessed using a paired t-test and a pairwise correlation test. Data of those who were lost to follow-up were evaluated. Results: Out of the 57 children 10 opted out of the study and of the remaining 47 children 20 (42.55%) were lost to follow-up. The mean age of the remaining 27 children was 9.04 ± 3.05 years and 48.1% (n = 13) were female. The mean age of dropouts was significantly higher than those who were followed up (P = 0.003). The mean duration of follow-up was 10.8 ± 5.1 months (range 3–23 months). The mean spherical equivalent from baseline to last follow-up was 0.329 by the paired sample t-test (P < 0.001). Twelve (44.4%) of the 27 children showed a progression of myopia despite treatment. Conclusion: Mean change in spherical equivalent in our study is comparable to previous studies with hardly any adverse effects suggesting efficacy of atropine 0.01%; practical hurdles in follow-up and adherence need to be improved with better patient education.
{"title":"Efficacy, feasibility, and patient acceptance of using low-dose atropine in retarding myopia progression: A general ophthalmologist's perspective","authors":"Lakshmi Cherungottil, Muhemmed Swadique, A. Ravindran, M. Safarulla, Usha P. Rani","doi":"10.4103/kjo.kjo_99_21","DOIUrl":"https://doi.org/10.4103/kjo.kjo_99_21","url":null,"abstract":"Purpose: Assessing efficacy of atropine 0.01% eye drops in retarding myopia progression in children, the feasibility of its use, and patient acceptance outside institutional practice. Design: Prospective observational hospital-based study was conducted in children who were prescribed aropine 0.01% eye drops to retard the progression of myopia. Methods: Fifty-seven children who showed a documented progression of ≥0.5 diopters (D) of myopia were prescribed atropine 0.01% eyedrops. In those patients who followed up, the mean change in spherical equivalent was assessed using a paired t-test and a pairwise correlation test. Data of those who were lost to follow-up were evaluated. Results: Out of the 57 children 10 opted out of the study and of the remaining 47 children 20 (42.55%) were lost to follow-up. The mean age of the remaining 27 children was 9.04 ± 3.05 years and 48.1% (n = 13) were female. The mean age of dropouts was significantly higher than those who were followed up (P = 0.003). The mean duration of follow-up was 10.8 ± 5.1 months (range 3–23 months). The mean spherical equivalent from baseline to last follow-up was 0.329 by the paired sample t-test (P < 0.001). Twelve (44.4%) of the 27 children showed a progression of myopia despite treatment. Conclusion: Mean change in spherical equivalent in our study is comparable to previous studies with hardly any adverse effects suggesting efficacy of atropine 0.01%; practical hurdles in follow-up and adherence need to be improved with better patient education.","PeriodicalId":32483,"journal":{"name":"Kerala Journal of Ophthalmology","volume":"34 1","pages":"240 - 244"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42254037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comments on: Off-center presentation of ocular myasthenia","authors":"Anooja Babu","doi":"10.4103/kjo.kjo_126_22","DOIUrl":"https://doi.org/10.4103/kjo.kjo_126_22","url":null,"abstract":"","PeriodicalId":32483,"journal":{"name":"Kerala Journal of Ophthalmology","volume":"34 1","pages":"291 - 291"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46155453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Ramesh, S. Ramesh, Anugraha Balamurugan, S. Ansar, A. Devadas, M. Ramesh, R. Rajasekaran
Aims: This study aims to evaluate the non-mydriatic fundus image quality obtained with a confocal fundus device. Also, to evaluate the influence of non-mydriatic pupil size on image quality. Settings and Design: A cross-sectional study was conducted in the outpatient department of a high-volume tertiary eye care centre in South India during the third phase of the COVID-19 lockdown. Subjects and Methods: 831 consenting, consecutive patients (1539 eyes) were photographed from May 5 to May 17, 2020, and were graded excellent, fair, adequate, or inadequate; based on white noise, black noise, and image acquisition signals. Pupil diameters were obtained with light-emitting diode flash technology. Statistical Analysis: The collected data were analyzed using SPSS software. Descriptive statistics in the form of frequencies and percentages were calculated. Simple (univariate) linear regression analysis and adjusted regression analysis were used to establish the relationship between pupil size and fundus photo quality. Results: The quality of the fundus photo was excellent in 70.12% (n = 1079), fair in 15.72% (n = 242), adequate in 5.78% (n = 89), and inadequate in 8.38% (n = 129). Of the 1410 obtained images (subtracting the inadequate quality images), 87.66% (n = 1236) were normal and 12.34% (n = 174) were pathological. There was a positive linear relationship between pupil size and quality of retinal photograph; OS (R2 = 0.935) had a slightly better association than OD (R2 = 0.901). Conclusions: The majority of the confocal images were excellent in quality. Our four-point grading system serves as a reliable measure of non-mydriatic photograph quality. Pupil size is a significant predictor of image quality for non-mydriatic photographs in surveillance programs.
{"title":"Evaluation of quality of non-mydriatic fundus images obtained with non-contact TrueColor, confocal scanner during third phase of nationwide lockdown","authors":"P. Ramesh, S. Ramesh, Anugraha Balamurugan, S. Ansar, A. Devadas, M. Ramesh, R. Rajasekaran","doi":"10.4103/kjo.kjo_58_21","DOIUrl":"https://doi.org/10.4103/kjo.kjo_58_21","url":null,"abstract":"Aims: This study aims to evaluate the non-mydriatic fundus image quality obtained with a confocal fundus device. Also, to evaluate the influence of non-mydriatic pupil size on image quality. Settings and Design: A cross-sectional study was conducted in the outpatient department of a high-volume tertiary eye care centre in South India during the third phase of the COVID-19 lockdown. Subjects and Methods: 831 consenting, consecutive patients (1539 eyes) were photographed from May 5 to May 17, 2020, and were graded excellent, fair, adequate, or inadequate; based on white noise, black noise, and image acquisition signals. Pupil diameters were obtained with light-emitting diode flash technology. Statistical Analysis: The collected data were analyzed using SPSS software. Descriptive statistics in the form of frequencies and percentages were calculated. Simple (univariate) linear regression analysis and adjusted regression analysis were used to establish the relationship between pupil size and fundus photo quality. Results: The quality of the fundus photo was excellent in 70.12% (n = 1079), fair in 15.72% (n = 242), adequate in 5.78% (n = 89), and inadequate in 8.38% (n = 129). Of the 1410 obtained images (subtracting the inadequate quality images), 87.66% (n = 1236) were normal and 12.34% (n = 174) were pathological. There was a positive linear relationship between pupil size and quality of retinal photograph; OS (R2 = 0.935) had a slightly better association than OD (R2 = 0.901). Conclusions: The majority of the confocal images were excellent in quality. Our four-point grading system serves as a reliable measure of non-mydriatic photograph quality. Pupil size is a significant predictor of image quality for non-mydriatic photographs in surveillance programs.","PeriodicalId":32483,"journal":{"name":"Kerala Journal of Ophthalmology","volume":"34 1","pages":"216 - 226"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41624619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Agrawal, R. Ramakrishnan, P. Gandhi, A. Choudhary
Ophthalmomyiasis is the myiasis of the eye, a relatively rare condition characterized by infestation of ocular and orbital tissues with fly larvae. Oestrus ovis being the most common causative organism. It typically occurs in shepherds and farmers in rural areas. The clinical symptoms depend on the extent of tissue invasion, which may include conjunctivitis, haemorrhage or ulceration. We report a case of 20 y/M who presented to us with foreign body sensation and watering in right eye since morning, and redness since 1 day. His visual acuity in right eye was 6/9 and in left eye was 6/6. On slit lamp examination, anterior segment of right eye revealed lid oedema, mucopurulent discharge, papillae, conjunctival congestion and moving larvae about 15-20 in number were seen on cornea and conjunctiva. Rest was unremarkable. Causative larvae were removed with forceps under topical anaesthesia followed by instillation of antibiotic eyedrop. The causative larvae were sent for microbiological examination and were identified as the first stage larvae of Oestrus ovis, the sheep nasal bot fly. Very few cases of external ophthalmomyiasis have been reported from urban areas of Maharashtra in India.
{"title":"External ophthalmomyiasis: Slither sign in orb","authors":"M. Agrawal, R. Ramakrishnan, P. Gandhi, A. Choudhary","doi":"10.4103/kjo.kjo_201_20","DOIUrl":"https://doi.org/10.4103/kjo.kjo_201_20","url":null,"abstract":"Ophthalmomyiasis is the myiasis of the eye, a relatively rare condition characterized by infestation of ocular and orbital tissues with fly larvae. Oestrus ovis being the most common causative organism. It typically occurs in shepherds and farmers in rural areas. The clinical symptoms depend on the extent of tissue invasion, which may include conjunctivitis, haemorrhage or ulceration. We report a case of 20 y/M who presented to us with foreign body sensation and watering in right eye since morning, and redness since 1 day. His visual acuity in right eye was 6/9 and in left eye was 6/6. On slit lamp examination, anterior segment of right eye revealed lid oedema, mucopurulent discharge, papillae, conjunctival congestion and moving larvae about 15-20 in number were seen on cornea and conjunctiva. Rest was unremarkable. Causative larvae were removed with forceps under topical anaesthesia followed by instillation of antibiotic eyedrop. The causative larvae were sent for microbiological examination and were identified as the first stage larvae of Oestrus ovis, the sheep nasal bot fly. Very few cases of external ophthalmomyiasis have been reported from urban areas of Maharashtra in India.","PeriodicalId":32483,"journal":{"name":"Kerala Journal of Ophthalmology","volume":"34 1","pages":"271 - 273"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46764067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report a case of phthiriasis palpebrarum, which was previously misdiagnosed as anterior blepharitis. Several lice and multiple nits were noted on the eyelashes in left eye under slit-lamp examination. The patient was successfully managed by mechanical removal of lice and nits after applying 20% fluorescein dye and subsequent treatment with 0.5% moxifloxacin eye ointment containing soft paraffin as the base.
{"title":"Phthiriasis palpebrarum - An easily missed diagnosis","authors":"K. Husna, Nimitha Nageeb","doi":"10.4103/kjo.kjo_89_22","DOIUrl":"https://doi.org/10.4103/kjo.kjo_89_22","url":null,"abstract":"We report a case of phthiriasis palpebrarum, which was previously misdiagnosed as anterior blepharitis. Several lice and multiple nits were noted on the eyelashes in left eye under slit-lamp examination. The patient was successfully managed by mechanical removal of lice and nits after applying 20% fluorescein dye and subsequent treatment with 0.5% moxifloxacin eye ointment containing soft paraffin as the base.","PeriodicalId":32483,"journal":{"name":"Kerala Journal of Ophthalmology","volume":"34 1","pages":"277 - 278"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41540759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Types of Study Designs","authors":"Sandhya Somasundaran","doi":"10.4103/kjo.kjo_125_22","DOIUrl":"https://doi.org/10.4103/kjo.kjo_125_22","url":null,"abstract":"","PeriodicalId":32483,"journal":{"name":"Kerala Journal of Ophthalmology","volume":"34 1","pages":"279 - 282"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48565929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akilandeswari Krishnan, C. Jayanthi, Sriya Sridhar
Background: Ocular itching is the hallmark symptom of allergic conjunctivitis, accompanied by tearing, conjunctival redness, eyelid swelling, and chemosis. Alcaftadine and olopatadine hydrochloride are classified as dual-acting antiallergic agents, used in the treatment of allergic conjunctivitis. Objective: The aim is to compare the efficacy and safety of alcaftadine 0.25% and olopatadine hydrochloride 0.2% eye drops among patients with allergic conjunctivitis. Settings and Design: Ophthalmology outpatient department at Minto Ophthalmic Hospital, Bangalore Medical College and Research Institute, Bengaluru; prospective, randomized, comparative study. Subjects and Methods: This study was conducted among 120 patients suffering from grade 3 Allergic conjunctivitis and efficacy measured in terms of proportion of patients achieving symptomatic relief of allergic ocular signs and symptoms from grade 3 to grade 0 from baseline to 2 weeks, using Total Ocular Symptoms Score (TOSS) and Conjunctival Hyperemia scale. Safety assessed by monitoring treatment-emergent adverse effects. Continuous data assessed by unpaired, paired t-test and repeated measures-ANOVA and categorical data by Chi-square test. P <0.05 was considered statistically significant, whereas < 0.001 as highly significant. Results: Greater proportion of patients achieved symptomatic relief in the Alcaftadine group (98.3%) compared to the olopatadine hydrochloride group (90%) at end of 2 weeks. A significant and faster reduction in TOSS score was observed from baseline to 2 weeks in alcaftadine treated group compared to the olopatadine hydrochloride group (P < 0.05). Adverse events reported were headache, burning sensation, and mild redness in both groups. Conclusion: Alcaftadine 0.25% demonstrated greater efficacy in reducing ocular signs and symptoms of allergic conjunctivitis from baseline to 2 weeks, compared to olopatadine hydrochloride 0.2% with minimal side-effects.
{"title":"A comparative study of efficacy and safety of alcaftadine 0.25% versus olopatadine hydrochloride 0.2% in allergic conjunctivitis at a tertiary care hospital","authors":"Akilandeswari Krishnan, C. Jayanthi, Sriya Sridhar","doi":"10.4103/kjo.kjo_185_21","DOIUrl":"https://doi.org/10.4103/kjo.kjo_185_21","url":null,"abstract":"Background: Ocular itching is the hallmark symptom of allergic conjunctivitis, accompanied by tearing, conjunctival redness, eyelid swelling, and chemosis. Alcaftadine and olopatadine hydrochloride are classified as dual-acting antiallergic agents, used in the treatment of allergic conjunctivitis. Objective: The aim is to compare the efficacy and safety of alcaftadine 0.25% and olopatadine hydrochloride 0.2% eye drops among patients with allergic conjunctivitis. Settings and Design: Ophthalmology outpatient department at Minto Ophthalmic Hospital, Bangalore Medical College and Research Institute, Bengaluru; prospective, randomized, comparative study. Subjects and Methods: This study was conducted among 120 patients suffering from grade 3 Allergic conjunctivitis and efficacy measured in terms of proportion of patients achieving symptomatic relief of allergic ocular signs and symptoms from grade 3 to grade 0 from baseline to 2 weeks, using Total Ocular Symptoms Score (TOSS) and Conjunctival Hyperemia scale. Safety assessed by monitoring treatment-emergent adverse effects. Continuous data assessed by unpaired, paired t-test and repeated measures-ANOVA and categorical data by Chi-square test. P <0.05 was considered statistically significant, whereas < 0.001 as highly significant. Results: Greater proportion of patients achieved symptomatic relief in the Alcaftadine group (98.3%) compared to the olopatadine hydrochloride group (90%) at end of 2 weeks. A significant and faster reduction in TOSS score was observed from baseline to 2 weeks in alcaftadine treated group compared to the olopatadine hydrochloride group (P < 0.05). Adverse events reported were headache, burning sensation, and mild redness in both groups. Conclusion: Alcaftadine 0.25% demonstrated greater efficacy in reducing ocular signs and symptoms of allergic conjunctivitis from baseline to 2 weeks, compared to olopatadine hydrochloride 0.2% with minimal side-effects.","PeriodicalId":32483,"journal":{"name":"Kerala Journal of Ophthalmology","volume":"34 1","pages":"227 - 233"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46634723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：