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Generation of HPMC-derived Placebo Hydrogel Component Matrix System for Possible Pharmaceutical 3D Printing Applications 生成 HPMC 衍生安慰剂水凝胶成分基质系统,用于可能的制药 3D 打印应用
Pub Date : 2023-08-17 DOI: 10.60142/ijhti.v2i02.06
Gantala Sarva Sai Nikhilesh
Integration of 3D bioprinting technology in the design and fabrication of pharmaceutical dosage form has the potential toovercome the limitations and expand the range of drugs that can be delivered through different routes. In recent years, thefield of bioprinting has emerged as a revolutionary technology with the potential to transform various aspects of the healthcareand pharmaceutical industries. Among its wide-ranging applications, one of the most promising areas is the development oftransdermal drug delivery systems using 3D bioprinting techniques. This innovative approach holds significant promise inenhancing drug delivery efficiency, improving patient compliance, and revolutionizing personalized medicine. 3D bioprintingtechnology offers exciting prospects for the development of transdermal patches specifically designed for wound healingapplications. With further advancements and research, these innovative patches have the potential to revolutionize the fieldof wound care and improve patient outcomes.
将三维生物打印技术整合到药物剂型的设计和制造中,有可能克服药物剂型的局限性,扩大可通过不同途径给药的药物范围。近年来,生物打印领域已成为一项革命性技术,有望改变医疗保健和制药行业的各个方面。在其广泛的应用领域中,最有前途的领域之一是利用三维生物打印技术开发透皮给药系统。这种创新方法在提高给药效率、改善患者依从性和革新个性化医疗方面大有可为。三维生物打印技术为开发专门用于伤口愈合的透皮贴剂提供了令人振奋的前景。随着技术的进一步发展和研究的深入,这些创新型贴片有望在伤口护理领域掀起一场革命,并改善患者的治疗效果。
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引用次数: 0
Introduction to Shape Memory Material: Biomedical, Prosthetic and Orthotic Application 形状记忆材料简介:生物医学、假肢和矫形器应用
Pub Date : 2023-08-17 DOI: 10.60142/ijhti.v2i02.07
Arpita Nayak, Kanhu C. Lenka, Devendra Jagdish Pingale
The need for prosthetic and orthotic devices is increasing significantly all over the world. Due to the increasing incidenceof sports injuries and road accidents, the rising number of diabetes-related amputations, and the growing prevalence ofosteosarcoma around the world are poised to drive the global market. Sports-induced injury is anticipated to drive demand,aiding market growth during the forecast period. The global prosthetics and orthotics market was valued at USD 6.39 billionin 2021 and is expected to expand at a compound annual growth rate (CAGR) of 4.3% from 2022 to 2030. Materials likepolymers (Polypropylene, Silicon, etc.), metals (Aluminium, Iron, etc.), alloys (stainless steel, bronze etc.), and carbon fibersare now used for making prosthetic and orthotic devices. Shape memory polymers (SMP) and shape memory alloys (SMA) arehaving ability to change and regain their original shape after changes in external stimuli like temperature, PH, heat, etc. Thisreview has discussed shape memory materials’ mechanical, chemical, and general properties, including their classification,advantages, disadvantages, FDA regulations, and applications in prosthetics and orthotics. This review will help prosthetists,orthotist, and biomedical engineers better understand these materials and how they increase the medical devices’ quality,durability and functionality.
全世界对假肢和矫形器的需求正在大幅增长。由于运动损伤和交通事故的发生率不断上升,与糖尿病相关的截肢人数不断增加,以及骨肉瘤在全球的发病率不断上升,这些因素都将推动全球市场的发展。预计在预测期内,运动引起的损伤将推动需求,促进市场增长。2021 年,全球假肢和矫形器市场价值为 63.9 亿美元,预计 2022 年至 2030 年的复合年增长率(CAGR)将达到 4.3%。目前,聚合物(聚丙烯、硅等)、金属(铝、铁等)、合金(不锈钢、青铜等)和碳纤维等材料已被用于制造假肢和矫形器。形状记忆聚合物(SMP)和形状记忆合金(SMA)具有在温度、PH 值、热量等外部刺激发生变化后改变并恢复原状的能力。本综述讨论了形状记忆材料的机械、化学和一般特性,包括它们的分类、优点、缺点、FDA 法规以及在假肢和矫形器中的应用。这篇综述将帮助修复师、矫形师和生物医学工程师更好地了解这些材料,以及它们如何提高医疗器械的质量、耐用性和功能性。
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引用次数: 0
Advanced Automation of Janu Dhara and Janu Basti Process in Ayurveda 阿育吠陀中 Janu Dhara 和 Janu Basti 过程的高级自动化
Pub Date : 2023-08-17 DOI: 10.60142/ijhti.v2i02.05
Avni Jain, Yash Panchal, Disha Choursiya, Bhavesh Adlak, Aman Ur R. Khan
The research aims to design a standalone automated janu dhara and janu basti system using an automatic temperature controller, pumping mechanism and sensor array. The paper consists of two parts: The mechanical design of the machine, which includes mechanical drawing, measurements, welding and fabrication, while the electrical part consists of electrical connections, heater, temperature controller and pumps. The prototype was successfully tested in an Ayurvedic clinic. The results were better accuracy in maintaining oil temperature throughout the process and reduced manual efforts of temperature monitoring and reheating oil by 50% compared to the manual procedure.
该研究旨在利用自动温度控制器、抽水机构和传感器阵列设计一个独立的自动简努达拉和简努巴斯提系统。论文由两部分组成:机器的机械设计包括机械制图、测量、焊接和制造,电气部分包括电气连接、加热器、温度控制器和泵。原型机在一家阿育吠陀诊所进行了成功测试。结果表明,在整个过程中保持油温的准确性更高,与人工操作相比,温度监测和重新加热油的工作量减少了 50%。
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引用次数: 0
Bone Plate Fabrication through 3D Printing: A Review of Methods and their Applications in Bone Regeneration 3D打印制作骨板:骨再生方法及其应用综述
Pub Date : 2023-04-12 DOI: 10.60142/ijhti.v2i01.78
Navnath Dukare, N. G, S. Balivada
There has been a lot of talk in recent times regarding the advantages of utilizing 3D printing as a novel approach to the production of implants, particularly customized ones. This technology has undergone significant advancements and enables the creation of intricate-shaped implants made of metal and polymer, which were previously challenging to produce using conventional techniques. Both metals and polymers have been utilized as biomaterials that can withstand pressure, making them suitable materials for producing such implants. This article aims to provide an overview of the 3D printing technique used to produce load-bearing implants made from metallic and polymeric materials.
最近有很多关于利用3D打印作为生产植入物的新方法的优点的讨论,特别是定制的植入物。这项技术已经取得了重大进展,可以制造由金属和聚合物制成的复杂形状的植入物,而以前使用传统技术很难制造这些植入物。金属和聚合物都被用作可以承受压力的生物材料,使它们成为制造这种植入物的合适材料。本文旨在概述用于生产由金属和聚合物材料制成的承重植入物的3D打印技术。
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引用次数: 0
Future of Bioprinting in Healthcare: A Review 生物打印在医疗保健中的未来:综述
Pub Date : 2023-04-12 DOI: 10.60142/ijhti.v2i01.76
Samir Das, S. Datta, Anamika Barman
Tissue damage and degeneration are common pathological phenomena in higher organisms, specifically in mammalians. However, the traditional method of organ transplantation is a gold standard treatment option for life-saving, dependent upon a donor’s availability. The scarcity of organ donors and the risk of graft rejection is mainly associated with adverse immune responses. Additive manufacturing, such as bioprinting, is one of the most advanced and state-of-the-art techniques that are being utilized for generating tissue engineering construct and in-vitro disease models. Three-dimensional bioprinting associate in creation of extracellular matrix (ECM), such as microenvironments for cells and computer-aided design (CAD) modification of planned tissue morphology. Herein, formulation of suitable bio-ink composition with optimized gelation kinetics for in-situ immobilization of cells with high cell viability is the utmost priority for bio-fabrication. This review elaborates on the most current opportunities and prospects for efficiently implementing bioprinting to restructure medical and technological practices and their applications in the healthcare industry.
组织损伤和变性是高等生物,特别是哺乳动物中常见的病理现象。然而,传统的器官移植方法是挽救生命的金标准治疗选择,取决于供体的可用性。器官供体的稀缺和移植排斥的风险主要与不良免疫反应有关。增材制造,如生物打印,是最先进和最先进的技术之一,用于生成组织工程构建和体外疾病模型。三维生物打印与细胞外基质(ECM)的创建有关,例如细胞微环境和计划组织形态的计算机辅助设计(CAD)修改。因此,制备合适的生物墨水组合物并优化凝胶动力学,以原位固定具有高细胞活力的细胞是生物制造的重中之重。这篇综述详细阐述了有效实施生物打印以重组医疗和技术实践及其在医疗保健行业中的应用的最新机会和前景。
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引用次数: 1
Development of Auditory and Speech Language Performance Following Bimodal Cochlear Implantation in a Pre-lingual Late Implantee: A Case Report 双模人工耳蜗植入术后听觉和言语语言表现的发展:一例报告
Pub Date : 2023-04-12 DOI: 10.60142/ijhti.v2i01.80
S. Vashist, Meenakshi Chabbra
Objective - To describe the performance in terms of auditory and speech-language development in a late implanted patient with bimodal cochlear implantation.Study Design - Prospective Case study.Subject – A girl with congenital bilateral sensorineural hearing loss with speech and language delay having left ear profound SNHL and right ear severe to profound SNHL.Intervention – Unilateral cochlear implant with neubio BOLD CI system done at the age of 15 years following auditory verbal therapy.Main Outcome Measures – “Meaningful auditory integration scale (MAIS)”, “Revised categories of auditory performance (Revised CAP)”, “Speech intelligibility rating (SIR)”, “Child using hearing devices QOL (cuHDQOL)”, 3D- language acquisition test (3D- LAT), “Parent evaluation aural/oral performance of children (PEACH)” and “Teacher evaluation aural/oral performance of children (TEACH)” is used to assess the outcomes of the cochlear implantation.Results – “Revised CAP,” “SIR,” “MAIS,” “cuHDQOL,” “3D-LAT”, “PEACH,” and “TEACH” scores showed improvement in the implanted teenager over time.Conclusion - The findings represent the evidence for better outcomes of late cochlear implanted patients with bimodal stimulation. It may also provide convincing results about the benefits with the use of Neubio BOLD Cochlear Implant system with a contralateral hearing aid.
目的:探讨双模人工耳蜗植入术晚期患者的听觉和语言发育情况。研究设计-前瞻性案例研究。对象:先天性双侧感音神经性听力丧失伴语言和语言延迟的女孩,左耳重度SNHL和右耳重度至重度SNHL。干预-在15岁的儿童接受听觉言语治疗后,使用neubio BOLD CI系统进行单侧人工耳蜗植入。主要观察指标:“有意义听觉整合量表(MAIS)”、“听觉表现修订分类量表(Revised CAP)”、“言语清晰度评分(SIR)”、“使用助听器儿童生活质量(cuHDQOL)”、3D语言习得测试(3D- LAT)、“家长儿童听觉/口语表现评价(PEACH)”和“教师儿童听觉/口语表现评价(TEACH)”用于评估人工耳蜗植入的结果。结果-“修订后的CAP”、“SIR”、“MAIS”、“cuHDQOL”、“3D-LAT”、“PEACH”和“TEACH”评分显示,随着时间的推移,植入青少年的情况有所改善。结论:本研究结果为晚期人工耳蜗植入患者采用双峰刺激治疗效果更好提供了证据。它也可能提供令人信服的结果,使用Neubio BOLD人工耳蜗系统与对侧助听器的好处。
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引用次数: 0
Non-human Intervention Robot in Biomedical Waste Management 生物医学废物管理中的非人干预机器人
Pub Date : 2023-04-12 DOI: 10.60142/ijhti.v2i01.75
Chapala Sara Grace, Grace, M. Sreeja, M. Deepika
Medical waste is one of the growing concerns worldwide, hidden in wolf’s clothing. A wide range of medical waste is being produced daily, which should be distinguished in its disposal and treatment. Collection, segregation and treatment of these wastes is quite problematic as it may spread diseases to the workers and cause harm. Biomedical waste management using autoclave incinerators, their establishment and maintenance is highly economical. We hereby come up with the idea of employing a robot under human control to collect, segregate and treat medical wastes
医疗废物是世界范围内日益受到关注的问题之一,它隐藏在狼的外衣之下。每天都在产生各种各样的医疗废物,在处置和处理方面应加以区分。这些废物的收集、分离和处理存在很大的问题,因为它可能给工人传播疾病并造成伤害。生物医学废物管理使用高压釜焚烧炉,其建立和维护是高度经济的。在此,我们提出了使用人工控制的机器人来收集、分类和处理医疗废物的想法
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引用次数: 0
Segmentation of Brain Tumor using Multiple Threshold Technique 基于多阈值技术的脑肿瘤分割
Pub Date : 2023-04-12 DOI: 10.60142/ijhti.v2i01.79
Ashalatha M E, M. Holi, Shubha V. Patel, Deepashri K M
Radiology use medical imaging techniques to comprehend the structure and physiological functions of the body in bothhealthy and diseased subjects. A non-invasive method for viewing internal body structures can be performed by using magneticresonance imaging (MRI). MRI characterizes soft tissue more accurately than other imaging methods like CT. In the currentstudy, space-occupying lesions are visualized using MRI imaging. Slices of MRI data are used to analyze lesions. Single sliceanalysis is inappropriate to determine the lesion’s size and volume. Hence, the MRI sequence is used to segment the lesions.Following segmentation, we view the MRI 2D image in 3D to look for lesions, or aberrant tissue, in the brain. The lesion isthen visualized by performing clipping. This research suggests segmenting brain tumors automatically and even provides a3D visualization for a more thorough study. Here, a space-occupying lesion is segmented from a T2 weighted Flair sequenceof MR images in DICOM format, and by employing the segmented volume, 3D rendering and clipping are made possible
放射学使用医学成像技术来了解健康和患病受试者的身体结构和生理功能。磁共振成像(MRI)是一种非侵入性的观察身体内部结构的方法。MRI比CT等其他成像方法更准确地表征软组织。在目前的研究中,占位性病变是通过MRI成像可视化的。MRI数据切片用于分析病变。单片分析不适合确定病变的大小和体积。因此,MRI序列用于分割病变。在分割之后,我们在3D中查看MRI 2D图像以寻找大脑中的病变或异常组织。然后通过剪接观察病变。这项研究建议对脑肿瘤进行自动分割,甚至为更深入的研究提供3d可视化。在这里,占位性病变以DICOM格式从MR图像的T2加权Flair序列中分割出来,通过使用分割的体积,可以实现3D渲染和剪切
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引用次数: 0
Medical Equipment Maintenance: Why is Prevention better than cure 医疗设备维护:为什么预防胜于治疗
Pub Date : 2023-04-12 DOI: 10.60142/ijhti.v2i01.74
Swati .
A wide range of medical equipment are used within medical institutions for prevention, monitoring, diagnosis and treatment, therefore, forming an integral part of the healthcare pathway. For healthcare providers, the proper functioning of these medical devices is of huge importance because of their role in delivering quality services to patients and considering the associated repair costs. Today, budget restrictions within numerous private and public healthcare facilities present a severe issue of patients being treated on ageing equipment, which are often also defective. This defeats the healthcare system’s primary purpose in offering patients quality care. It also risks the operational efficiency and reputation of such medical facilities.
医疗机构内使用各种各样的医疗设备进行预防、监测、诊断和治疗,因此,它们构成了医疗保健途径的一个组成部分。对于医疗保健提供者来说,这些医疗设备的正常运行非常重要,因为它们在为患者提供高质量服务和考虑相关的维修成本方面发挥着重要作用。今天,许多私人和公共医疗保健机构的预算限制造成了一个严重问题,即患者在老化的设备上接受治疗,这些设备往往也有缺陷。这违背了医疗保健系统为患者提供优质护理的主要目的。它还危及此类医疗设施的业务效率和声誉。
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引用次数: 0
Transition from Analog to Digital Imaging for Image Guided Surgeries 图像引导手术从模拟成像到数字成像的过渡
Pub Date : 2022-12-23 DOI: 10.60142/ijhti.v1i03.54
Satyaki Banerjee
C-arms and Cath-labs are sophisticated medical imaging equipment that finds extensive use in various operating room settings for image guided surgeries. Cath-labs are generally used for cardio-vascular procedures like angiography, angioplasty, and complex neurosurgeries. Mobile C-arms find usage in predominantly orthopaedic, urology, spine and general surgeries.
c型臂和导管实验室是复杂的医学成像设备,广泛用于各种手术室的图像引导手术。导管室通常用于心血管手术,如血管造影术、血管成形术和复杂的神经外科手术。移动c型臂主要用于骨科、泌尿外科、脊柱和普通外科。
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引用次数: 1
期刊
International Journal of Health Technology and Innovation
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