Ana Gilabert-Garcia, Cristina Cristina Villarreal Guerrero, Rodrigo Dagio-Cuéllar, J. Bermudez-Gonzalez, Arantza Marie Perez-Partida, Joaquin Berarducci, J. I. Armenta-Moreno, J.A. Luna-Alvarez-Amezquita, Juan Ignacio Straface, N. Espinola-Zavaleta, E. Alexanderson
Coronary artery disease (CAD) and ischemic heart disease (IHD) are often indistinctly used terms. Both combined have generated, over the past years, concerns about sex disparities in their presentation. From an epidemiological perspective, females have several disadvantages regarding the prevention, diagnosis, and treatment of CAD. Most of the general cardiovascular risk factors affect women more frequently, or with a higher morbidity and mortality association. Besides, atypical manifestations of the disease and uncommon forms of CAD represent a diagnostic challenge for clinicians. Even if current treatments for CAD have no apparent sex bias, women representation in clinical trials and treatment patterns analyzed in clinical practice refuse this statement. Several disparities are caused by inevitable sex-particularities, but many of them are more social, cultural, and dogmatic beliefs that have to be addressed and overhaul.
{"title":"Coronary Artery Disease in Women: Getting to Know Gender Related Disparities","authors":"Ana Gilabert-Garcia, Cristina Cristina Villarreal Guerrero, Rodrigo Dagio-Cuéllar, J. Bermudez-Gonzalez, Arantza Marie Perez-Partida, Joaquin Berarducci, J. I. Armenta-Moreno, J.A. Luna-Alvarez-Amezquita, Juan Ignacio Straface, N. Espinola-Zavaleta, E. Alexanderson","doi":"10.36660/ijcs.20220022","DOIUrl":"https://doi.org/10.36660/ijcs.20220022","url":null,"abstract":"Coronary artery disease (CAD) and ischemic heart disease (IHD) are often indistinctly used terms. Both combined have generated, over the past years, concerns about sex disparities in their presentation. From an epidemiological perspective, females have several disadvantages regarding the prevention, diagnosis, and treatment of CAD. Most of the general cardiovascular risk factors affect women more frequently, or with a higher morbidity and mortality association. Besides, atypical manifestations of the disease and uncommon forms of CAD represent a diagnostic challenge for clinicians. Even if current treatments for CAD have no apparent sex bias, women representation in clinical trials and treatment patterns analyzed in clinical practice refuse this statement. Several disparities are caused by inevitable sex-particularities, but many of them are more social, cultural, and dogmatic beliefs that have to be addressed and overhaul.","PeriodicalId":32690,"journal":{"name":"International Journal of Cardiovascular Sciences","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84089428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Cristina Meira Ferreira, D. Nercolini, Mayara Viana de Oliveira, M. A. Santos, F. Mangione, V. Lemke, Maria Sanali Moura Paiva, G. Oliveira
Degenerative aortic stenosis is currently a public health problem. Affecting the elderly population, this pathology has been showing an increasing prevalence as a direct result of the population aging. In this context, women have a greater life expectancy, corresponding to most of the population with degenerative aortic stenosis. Specific characteristics of this pathology in females are present in the diagnosis, pathophysiology, anatomical aspects, imaging and in therapeutic approach. Women present a more severe disease with less valve calcification than men, more concentric ventricular remodeling, higher transvalvular gradients, and less myocardial fibrosis. Less evident symptoms mean that these patients are referred later for surgical or percutaneous therapeutic treatment. The greater comorbidity presented by females and possibly due to the smaller body surface, bring specific aspects that affect the surgery results, leading to higher mortality rates and, more often, the prosthesis-patient mismatch. Percutaneous valve implantation is a good alternative, with better results in females, when compared to surgery, both in the treatment of native valves and in the treatment of a previously implanted bioprosthesis’ dysfunction. The challenges encountered for the treatment of aortic stenosis in women and their possible solutions are described in this article, focusing on the observed difference of aortic stenosis in females and their possible solutions .
{"title":"Degenerative Aortic Stenosis in Women: Challenges and Perspectives","authors":"Maria Cristina Meira Ferreira, D. Nercolini, Mayara Viana de Oliveira, M. A. Santos, F. Mangione, V. Lemke, Maria Sanali Moura Paiva, G. Oliveira","doi":"10.36660/ijcs.20210261","DOIUrl":"https://doi.org/10.36660/ijcs.20210261","url":null,"abstract":"Degenerative aortic stenosis is currently a public health problem. Affecting the elderly population, this pathology has been showing an increasing prevalence as a direct result of the population aging. In this context, women have a greater life expectancy, corresponding to most of the population with degenerative aortic stenosis. Specific characteristics of this pathology in females are present in the diagnosis, pathophysiology, anatomical aspects, imaging and in therapeutic approach. Women present a more severe disease with less valve calcification than men, more concentric ventricular remodeling, higher transvalvular gradients, and less myocardial fibrosis. Less evident symptoms mean that these patients are referred later for surgical or percutaneous therapeutic treatment. The greater comorbidity presented by females and possibly due to the smaller body surface, bring specific aspects that affect the surgery results, leading to higher mortality rates and, more often, the prosthesis-patient mismatch. Percutaneous valve implantation is a good alternative, with better results in females, when compared to surgery, both in the treatment of native valves and in the treatment of a previously implanted bioprosthesis’ dysfunction. The challenges encountered for the treatment of aortic stenosis in women and their possible solutions are described in this article, focusing on the observed difference of aortic stenosis in females and their possible solutions .","PeriodicalId":32690,"journal":{"name":"International Journal of Cardiovascular Sciences","volume":"158 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82916868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
responsible for approximately 4% of all sudden cardiac deaths (SCDs) and nearly 20% of all SCDs in individuals with structurally normal hearts. 8 Currently, the sodium channel protein type V subunit α gene (SCN5A) is the primary gene linked to BrS, and roughly 30% of all documented cases are imputable to one of the gene’s more than 350 genetic variants. 9 Since the first description of genetic mutation related to BrS (1998), around 500 sporadic mutations in more than 40 genes have been described as likely related to BrS. These genes mainly encode sodium, potassium, and calcium channels, as well as related proteins. 10 The discovery of additional genes that may be linked to BrS has enabled genetic screening in clinical assessment. Nonetheless, an extensive study of all probable BrS-associated genes has shown a disorder mutation in less than 40% of all confirmed cases; thus, the genetic origin of the condition remains undiscovered in most families. 11
{"title":"Adding the Exercise Test as a Tool in the Medical Decision-Making Process in Brugada Syndrome","authors":"L. Mastrocola, Fábio Mastrocola","doi":"10.36660/ijcs.20230053","DOIUrl":"https://doi.org/10.36660/ijcs.20230053","url":null,"abstract":"responsible for approximately 4% of all sudden cardiac deaths (SCDs) and nearly 20% of all SCDs in individuals with structurally normal hearts. 8 Currently, the sodium channel protein type V subunit α gene (SCN5A) is the primary gene linked to BrS, and roughly 30% of all documented cases are imputable to one of the gene’s more than 350 genetic variants. 9 Since the first description of genetic mutation related to BrS (1998), around 500 sporadic mutations in more than 40 genes have been described as likely related to BrS. These genes mainly encode sodium, potassium, and calcium channels, as well as related proteins. 10 The discovery of additional genes that may be linked to BrS has enabled genetic screening in clinical assessment. Nonetheless, an extensive study of all probable BrS-associated genes has shown a disorder mutation in less than 40% of all confirmed cases; thus, the genetic origin of the condition remains undiscovered in most families. 11","PeriodicalId":32690,"journal":{"name":"International Journal of Cardiovascular Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86277419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guilherme de Andrade Costa, J. Oliveira, Luana Ferreira-Campos, A. Improta-Caria, C. Macedo, Marcelo Vincenzo Sarno, Leonardo Silva Roever Borges, Roque Aras Júnior
Background: Refractory hypertension (RfH) is a severe phenotype of resistant hypertension (RH) linked to higher risk of stroke and other adverse cardiovascular events, but knowledge about it is still lacking. Objectives: To evaluate the association between RfH and stroke. Methods: We conducted a cross-sectional study in a referral clinic for patients with severe hypertension in the period from 2018 to 2020. RH was defined as uncontrolled blood pressure (BP) despite the use of 3 antihypertensive agents, including a diuretic, or the use of ≥ 4 agents regardless of BP control. RfH was defined as lack of BP control despite use of ≥ 5 antihypertensive agents. Individuals were classified as RfH or RH, and multivariate logistic regression models were constructed to examine the association between RfH and stroke. Results: We evaluated a total of 137 patients; 81% were female, and 93,3% were Black or multiracial. The mean age was 64.4 years. Stroke was more prevalent in the RfH group (35.7%), in comparison to the RH group (12.8%) (p value = 0.01). Unadjusted odds ratio (OR) and 95% confidence interval (CI) for factors associated with stroke were RfH (OR 3.77; 95% CI 1.45 to 9.80), systolic BP (OR 1.02; 95% CI 1.002 to 1.04) and diastolic BP (OR 1.03; 95% CI 1.001 to 1.06). Adjusted OR for factors associated with stroke were RfH (OR 3.55; 95% CI 1.02 to 12.42), systolic BP (OR 1.02; 95% CI 0.99 to 1.05) and diastolic BP (OR 1.01; 95% CI 0.96 to 1.06). Conclusion: RfH was associated with higher prevalence of stroke. Efforts are required to better understand this association to prevent adverse cardiovascular outcomes in these patients.
背景:难治性高血压(RfH)是顽固性高血压(RH)的一种严重表型，与卒中和其他不良心血管事件的高风险相关，但对其的认识仍然缺乏。目的:评价RfH与脑卒中的关系。方法:我们在一家转诊诊所对2018 - 2020年期间的重度高血压患者进行了横断面研究。RH被定义为:尽管使用了3种降压药，包括一种利尿剂，但血压(BP)仍未控制，或使用了≥4种降压药，无论血压是否得到控制。RfH定义为尽管使用了≥5种降压药，但血压仍未得到控制。将个体分为RfH或RH，并构建多变量logistic回归模型来检验RfH与卒中之间的关系。结果:我们共评估了137例患者;81%为女性，93%为黑人或多种族。平均年龄64.4岁。与RH组(12.8%)相比，RfH组(35.7%)卒中发生率更高(p值= 0.01)。卒中相关因素的未调整优势比(OR)和95%可信区间(CI)为RfH (OR 3.77;95% CI 1.45 ~ 9.80)，收缩压(OR 1.02;95% CI 1.002 ~ 1.04)和舒张压(OR 1.03;95% CI 1.001 ~ 1.06)。卒中相关因素的调整OR为RfH (OR 3.55;95% CI 1.02 ~ 12.42)，收缩压(OR 1.02;95% CI 0.99 ~ 1.05)和舒张压(OR 1.01;95% CI 0.96 ~ 1.06)。结论:RfH与卒中发生率增高有关。需要努力更好地了解这种关联，以预防这些患者的不良心血管结局。
{"title":"Stroke Is Associated with Refractory Hypertension among Resistant and Refractory Patients in a Cross-Sectional Study","authors":"Guilherme de Andrade Costa, J. Oliveira, Luana Ferreira-Campos, A. Improta-Caria, C. Macedo, Marcelo Vincenzo Sarno, Leonardo Silva Roever Borges, Roque Aras Júnior","doi":"10.36660/ijcs.20220175","DOIUrl":"https://doi.org/10.36660/ijcs.20220175","url":null,"abstract":"Background: Refractory hypertension (RfH) is a severe phenotype of resistant hypertension (RH) linked to higher risk of stroke and other adverse cardiovascular events, but knowledge about it is still lacking. Objectives: To evaluate the association between RfH and stroke. Methods: We conducted a cross-sectional study in a referral clinic for patients with severe hypertension in the period from 2018 to 2020. RH was defined as uncontrolled blood pressure (BP) despite the use of 3 antihypertensive agents, including a diuretic, or the use of ≥ 4 agents regardless of BP control. RfH was defined as lack of BP control despite use of ≥ 5 antihypertensive agents. Individuals were classified as RfH or RH, and multivariate logistic regression models were constructed to examine the association between RfH and stroke. Results: We evaluated a total of 137 patients; 81% were female, and 93,3% were Black or multiracial. The mean age was 64.4 years. Stroke was more prevalent in the RfH group (35.7%), in comparison to the RH group (12.8%) (p value = 0.01). Unadjusted odds ratio (OR) and 95% confidence interval (CI) for factors associated with stroke were RfH (OR 3.77; 95% CI 1.45 to 9.80), systolic BP (OR 1.02; 95% CI 1.002 to 1.04) and diastolic BP (OR 1.03; 95% CI 1.001 to 1.06). Adjusted OR for factors associated with stroke were RfH (OR 3.55; 95% CI 1.02 to 12.42), systolic BP (OR 1.02; 95% CI 0.99 to 1.05) and diastolic BP (OR 1.01; 95% CI 0.96 to 1.06). Conclusion: RfH was associated with higher prevalence of stroke. Efforts are required to better understand this association to prevent adverse cardiovascular outcomes in these patients.","PeriodicalId":32690,"journal":{"name":"International Journal of Cardiovascular Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83517254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
+CD16+ monocytes (intermediate and non-classical), which are associated with the thickness of the coronary fibrous cap in atherosclerotic lesions. 6 On the other hand, in patients with stable angina, CD14+CD16+ was shown to be associated with the vulnerability of atherosclerotic plaque. 7 These laboratory data are of paramount importance for the management of these patients, and it has been observed that CD14+CD16+ monocytes have a greater capacity to interact with endothelial cells, greater ability to present antigens, and increased expression of inflammatory cytokines compared to CD14+CD16+. 5 These findings demonstrate that CD14++CD16+ monocytes are associated with cardiovascular disease and the progression and instability of atherosclerotic plaque. These data will increase the understanding of the current state of patients with atherosclerosis in the therapeutic and temporal management of the current inflammatory state. For
{"title":"Monocyte Inflammatory Signaling","authors":"F. Costa","doi":"10.36660/ijcs.20230025","DOIUrl":"https://doi.org/10.36660/ijcs.20230025","url":null,"abstract":"+CD16+ monocytes (intermediate and non-classical), which are associated with the thickness of the coronary fibrous cap in atherosclerotic lesions. 6 On the other hand, in patients with stable angina, CD14+CD16+ was shown to be associated with the vulnerability of atherosclerotic plaque. 7 These laboratory data are of paramount importance for the management of these patients, and it has been observed that CD14+CD16+ monocytes have a greater capacity to interact with endothelial cells, greater ability to present antigens, and increased expression of inflammatory cytokines compared to CD14+CD16+. 5 These findings demonstrate that CD14++CD16+ monocytes are associated with cardiovascular disease and the progression and instability of atherosclerotic plaque. These data will increase the understanding of the current state of patients with atherosclerosis in the therapeutic and temporal management of the current inflammatory state. For","PeriodicalId":32690,"journal":{"name":"International Journal of Cardiovascular Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73693154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In investigations in several areas, regardless of their purposes, the use of information systems is frequently observed. An information system is complex, but, according to Siqueira, initially, it is composed of three basic elements: data, information, and knowledge.1 The data, according to the author, would be the smallest particle of this system. It is the element from registration, without any analysis. It is essential, as it will affect the other elements depending on how it is registered. Data quality is influenced by the following: reliability, it corresponds to the reality of the event; up-to-dateness, the registered data is made available in a timely manner for its use; and completeness, the data covers all the characteristics of the investigated event.2 Information is regularly formed by a set of data. It comes from combining and analyzing several data. Knowledge comes from factors related to the use of information such as interpretation and applicability.
{"title":"The Use of Health Information Systems for Investigations","authors":"P. H. Godoy","doi":"10.36660/ijcs.20230020","DOIUrl":"https://doi.org/10.36660/ijcs.20230020","url":null,"abstract":"In investigations in several areas, regardless of their purposes, the use of information systems is frequently observed. An information system is complex, but, according to Siqueira, initially, it is composed of three basic elements: data, information, and knowledge.1 The data, according to the author, would be the smallest particle of this system. It is the element from registration, without any analysis. It is essential, as it will affect the other elements depending on how it is registered. Data quality is influenced by the following: reliability, it corresponds to the reality of the event; up-to-dateness, the registered data is made available in a timely manner for its use; and completeness, the data covers all the characteristics of the investigated event.2 Information is regularly formed by a set of data. It comes from combining and analyzing several data. Knowledge comes from factors related to the use of information such as interpretation and applicability.","PeriodicalId":32690,"journal":{"name":"International Journal of Cardiovascular Sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90398537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcia Cristina Lacerda das Judas, R. F. Fontes, Renata Ferreira de Moura, Larissa dos Santos, M. D. Almeida, Vinicius Gomes
Introduction: Myocardial revascularization surgery is associated with high morbidity and mortality, due to factors like the general anesthesia and the surgical procedure itself. Physiotherapy, combined with early mobilization (EM), can provide the patient with better functional parameters. Objective: To review, identify and describe the effectiveness of EM in the prevention and rehabilitation of functional parameters of coronary artery bypass graft surgery. Methodology: This is a systematic review conducted between February 2020 and 2021 of randomized clinical trials (RCTs) published in the Cochrane databases Library, LILACS, Scielo and Medline / PubMed. The Physiotherapy Evidence Database (PEDro) scale was used for assessment of the methodological quality of studies included. Results: Four studies were reviewed. Two articles assessed functional capacity, one using the cycle ergometer and one with inspiratory muscle training (IMT) together with active exercises and early walking. One article reported a reduction in the incidence of atelectasis and pleural effusion with EM and one article reported improvements in the alveolus-artery gradient and inspiratory muscle power using an inspiratory muscle trainer combined with EM. Conclusion: EM is effective in the prevention and rehabilitation of functional parameters after CABG surgery, by improving functional capacity, respiratory muscle power, quality of life and gas exchange, and reducing the incidence of atelectasis and pleural effusion.
{"title":"Effectiveness of Early Mobilization in Prevention and Rehabilitation of Functional Impairment After Myocardial Revascularization Surgery: A Systematic Review","authors":"Marcia Cristina Lacerda das Judas, R. F. Fontes, Renata Ferreira de Moura, Larissa dos Santos, M. D. Almeida, Vinicius Gomes","doi":"10.36660/ijcs.20210166","DOIUrl":"https://doi.org/10.36660/ijcs.20210166","url":null,"abstract":"Introduction: Myocardial revascularization surgery is associated with high morbidity and mortality, due to factors like the general anesthesia and the surgical procedure itself. Physiotherapy, combined with early mobilization (EM), can provide the patient with better functional parameters. Objective: To review, identify and describe the effectiveness of EM in the prevention and rehabilitation of functional parameters of coronary artery bypass graft surgery. Methodology: This is a systematic review conducted between February 2020 and 2021 of randomized clinical trials (RCTs) published in the Cochrane databases Library, LILACS, Scielo and Medline / PubMed. The Physiotherapy Evidence Database (PEDro) scale was used for assessment of the methodological quality of studies included. Results: Four studies were reviewed. Two articles assessed functional capacity, one using the cycle ergometer and one with inspiratory muscle training (IMT) together with active exercises and early walking. One article reported a reduction in the incidence of atelectasis and pleural effusion with EM and one article reported improvements in the alveolus-artery gradient and inspiratory muscle power using an inspiratory muscle trainer combined with EM. Conclusion: EM is effective in the prevention and rehabilitation of functional parameters after CABG surgery, by improving functional capacity, respiratory muscle power, quality of life and gas exchange, and reducing the incidence of atelectasis and pleural effusion.","PeriodicalId":32690,"journal":{"name":"International Journal of Cardiovascular Sciences","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85624454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vanessa Zanoni Carvalhaes, G. Meireles, R. M. Catarino, Rosemeire Bueno
,
，
{"title":"Association between the Phytochemical Index and Risk Factors for Cardiovascular Disease in Adults","authors":"Vanessa Zanoni Carvalhaes, G. Meireles, R. M. Catarino, Rosemeire Bueno","doi":"10.36660/ijcs.20220055","DOIUrl":"https://doi.org/10.36660/ijcs.20220055","url":null,"abstract":",","PeriodicalId":32690,"journal":{"name":"International Journal of Cardiovascular Sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74819176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Camila Pinto Cavalcante Miná, E. A. V. Rocha, D. Mont’Alverne, Eduardo Arrais Rocha
Brugada syndrome (BS) is a genetic channelopathy, clinically characterized by an increased risk of sudden cardiac death. The diagnosis requires a typical electrocardiographic pattern, and data on risk stratification are limited in the literature. The aim of this study was to conduct a review on the importance of exercise stress test (EST) in risk stratification in BS. Articles were searched in the PubMed, Scielo and Google Scholar databases. From the 200 articles retrieved, eight were included, with a total of 712 patients (95% men) aged between 35 and 60 years. Severe symptoms and ventricular arrhythmias were reported by 256 patients before the EST, with syncope being reported in 70% of cases. The reviewed articles suggest that the EST is a safe method that can help in the diagnosis and risk stratification for malignant arrhythmias in patients with BS. Potential predictors of poor prognosis were: augmentation in ST-segment elevation > 0.5 mV in V1, V2 or V3 in early recovery; J-point elevation in lead > 2mm in aVR in late recovery; heart rate reduction < 40% from maximum heart rate in late recovery and occurrence of ventricular extrasystoles in early recovery.
{"title":"Exercise Stress Test in The Assessment of Brugada Syndrome Patients","authors":"Camila Pinto Cavalcante Miná, E. A. V. Rocha, D. Mont’Alverne, Eduardo Arrais Rocha","doi":"10.36660/ijcs.20220079","DOIUrl":"https://doi.org/10.36660/ijcs.20220079","url":null,"abstract":"Brugada syndrome (BS) is a genetic channelopathy, clinically characterized by an increased risk of sudden cardiac death. The diagnosis requires a typical electrocardiographic pattern, and data on risk stratification are limited in the literature. The aim of this study was to conduct a review on the importance of exercise stress test (EST) in risk stratification in BS. Articles were searched in the PubMed, Scielo and Google Scholar databases. From the 200 articles retrieved, eight were included, with a total of 712 patients (95% men) aged between 35 and 60 years. Severe symptoms and ventricular arrhythmias were reported by 256 patients before the EST, with syncope being reported in 70% of cases. The reviewed articles suggest that the EST is a safe method that can help in the diagnosis and risk stratification for malignant arrhythmias in patients with BS. Potential predictors of poor prognosis were: augmentation in ST-segment elevation > 0.5 mV in V1, V2 or V3 in early recovery; J-point elevation in lead > 2mm in aVR in late recovery; heart rate reduction < 40% from maximum heart rate in late recovery and occurrence of ventricular extrasystoles in early recovery.","PeriodicalId":32690,"journal":{"name":"International Journal of Cardiovascular Sciences","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84481526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SUS hospitalization forms; for example, code I63, which was left out, corresponds to cerebral infarction. Population aging clearly increases the incidence and prevalence of chronic noncommunicable diseases, such as stroke. 1 The article under analysis presents its results by age group. However, we are curious to see the behavior of the rates presented with adjustment for age, removing the effect of aging and thus verifying how the rates would be standardized by age. The analyzed article should be valued, as it studies databases with thousands of occurrences. It generates new information of significant importance for one of the leading causes of death and disability in the world today. The authors offer a clear, objective, and well-written discussion of the analysis of their findings. Finally, it contributes to the understanding of the occurrence, over the years, of cerebrovascular disease in the most populous Brazilian region
{"title":"Analyzing the Impact of Stroke in the Southeast Region of Brazil","authors":"G. P. Soares, T. Salim","doi":"10.36660/ijcs.20230052","DOIUrl":"https://doi.org/10.36660/ijcs.20230052","url":null,"abstract":"SUS hospitalization forms; for example, code I63, which was left out, corresponds to cerebral infarction. Population aging clearly increases the incidence and prevalence of chronic noncommunicable diseases, such as stroke. 1 The article under analysis presents its results by age group. However, we are curious to see the behavior of the rates presented with adjustment for age, removing the effect of aging and thus verifying how the rates would be standardized by age. The analyzed article should be valued, as it studies databases with thousands of occurrences. It generates new information of significant importance for one of the leading causes of death and disability in the world today. The authors offer a clear, objective, and well-written discussion of the analysis of their findings. Finally, it contributes to the understanding of the occurrence, over the years, of cerebrovascular disease in the most populous Brazilian region","PeriodicalId":32690,"journal":{"name":"International Journal of Cardiovascular Sciences","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75233568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：