Pub Date : 2023-01-13DOI: 10.32007/jfacmedbagdad.6441936
Isra A. Abd Ala, Nada Abdul Wahhab Mousa, F. Al-Lami
Background: Chronic obstructive pulmonary disease causes permanent morbidity, premature mortality and great burden to the healthcare system. Smoking is it's most common risk factor and Spirometry is for diagnosing COPD and monitoring its progression. Objectives: Early detection of chronic obstructive pulmonary disease in symptomatic smokers’ ≥ 40years by spirometry. Methods: A cross sectional study on all symptomatic smokers aged ≥ 40 years attending ten PHCCs in Baghdad Alkarkh and Alrisafa. Those whose FEV1/FVC was <70% on spirometry; after giving bronchodilator, were considered COPD +ve. Results: Overall, airway obstruction was seen in 206(46.8%). It is significantly associated with increase age (50-y), more in male and increase with increase duration and amount of smoking Conclusions: COPD was prevalent among men and women. Early diagnosis of COPD is good for both patient and community. Routine spirometry is an easy way for screening and identifying asymptomatic patients. Before adoption of spirometry Cost-effectiveness is needed.
{"title":"Detection of Chronic Obstructive Pulmonary Disease among Smokers Aged ≥40 years Attending Primary Health Care Centers in Baghdad-AL-Karkh and AL-Resafa","authors":"Isra A. Abd Ala, Nada Abdul Wahhab Mousa, F. Al-Lami","doi":"10.32007/jfacmedbagdad.6441936","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441936","url":null,"abstract":"Background: Chronic obstructive pulmonary disease causes permanent morbidity, premature mortality and great burden to the healthcare system. Smoking is it's most common risk factor and Spirometry is for diagnosing COPD and monitoring its progression.\u0000Objectives: Early detection of chronic obstructive pulmonary disease in symptomatic smokers’ ≥ 40years by spirometry.\u0000Methods: A cross sectional study on all symptomatic smokers aged ≥ 40 years attending ten PHCCs in Baghdad Alkarkh and Alrisafa. Those whose FEV1/FVC was <70% on spirometry; after giving bronchodilator, were considered COPD +ve.\u0000Results: Overall, airway obstruction was seen in 206(46.8%). It is significantly associated with increase age (50-y), more in male and increase with increase duration and amount of smoking\u0000Conclusions: COPD was prevalent among men and women. Early diagnosis of COPD is good for both patient and community. Routine spirometry is an easy way for screening and identifying asymptomatic patients. Before adoption of spirometry Cost-effectiveness is needed.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47049768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-13DOI: 10.32007/jfacmedbagdad.6441978
Islam Alazawi
Background: There are several diseases in the body following recovery from COVID-19 infection because this virus operates on human genes in various types of peripheral tissue in the human body. It penetrates host cells via Angiotensin-converting enzyme-2 receptors and may have effects on bone remodeling, leading to osteopenia or osteoporosis, which are characterized by low bone mineral density, resulting in diminished bone strength. Bone Alkaline Phpsphatase is an enzyme released into the bloodstream as a soluble homodimer after being cleaved by a phospholipase and can be utilized as a biomarker of bone development. Objective: This research was designed to investigate the alteration of bone homeostasis balance in Iraqi post-COVID-19 infection patients. Cases and Methods: This is a case control study. The study has received approval from the ethical committee at the Faculty of Medicine, Baghdad University, established on November 20, 2021–March 2, 2022. A hundred and thirty individuals were enrolled in this study. The subjects were divided into two groups; the first group (80) post-COVID-19 infection patients and the second group (50) non-COVID-19 individuals. Also, measuring markers like serum Angiotensin-converting enzyme-2 and Bone Alkaline Phosphatase by using the ELISA technique. The bone mineral density was measured by a DEXA scan. Results:This study found that there is an effect of coronavirus infection on the bone strength measured by the mean ± SD Bone Alkaline Phosphatase level, which was found to be highly significant in the serum of post-COVID-19 patients when compared with non-COVID-19 individuals (P-value = 0.001), but the mean ± SD of Angiotensin-converting enzyme-2 level was statistically non-significant between the two groups (P-value = 0.13). who had recovered from a coronavirus infection for 3 months or more. Also, the bone mineral density of Post COVID-19 patients that was measured by DEXA scan had a highly significant T-score% when compared between the two groups. Conclusions:This research found that COVID-19 has an impact on the bone remodeling process, leading to osteopenia or osteoporosis, which may be identified by checking the blood levels of the bone biomarker BAP and the bone mineral density (by DEXA scan) at least three months following coronavirus recovery. This investigation also discovered that some of the individuals had osteopenia rather than osteoporosis.
{"title":"Measuring of Specific Bone Alkaline phosphatase ( BAP ) Bone Remodeling biomarker for Post-COVID Iraqi Patient","authors":"Islam Alazawi","doi":"10.32007/jfacmedbagdad.6441978","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441978","url":null,"abstract":"Background: There are several diseases in the body following recovery from COVID-19 infection because this virus operates on human genes in various types of peripheral tissue in the human body. It penetrates host cells via Angiotensin-converting enzyme-2 receptors and may have effects on bone remodeling, leading to osteopenia or osteoporosis, which are characterized by low bone mineral density, resulting in diminished bone strength. Bone Alkaline Phpsphatase is an enzyme released into the bloodstream as a soluble homodimer after being cleaved by a phospholipase and can be utilized as a biomarker of bone development.\u0000Objective: This research was designed to investigate the alteration of bone homeostasis balance in Iraqi post-COVID-19 infection patients.\u0000Cases and Methods: This is a case control study. The study has received approval from the ethical committee at the Faculty of Medicine, Baghdad University, established on November 20, 2021–March 2, 2022. A hundred and thirty individuals were enrolled in this study. The subjects were divided into two groups; the first group (80) post-COVID-19 infection patients and the second group (50) non-COVID-19 individuals. Also, measuring markers like serum Angiotensin-converting enzyme-2 and Bone Alkaline Phosphatase by using the ELISA technique. The bone mineral density was measured by a DEXA scan.\u0000Results:This study found that there is an effect of coronavirus infection on the bone strength measured by the mean ± SD Bone Alkaline Phosphatase level, which was found to be highly significant in the serum of post-COVID-19 patients when compared with non-COVID-19 individuals (P-value = 0.001), but the mean ± SD of Angiotensin-converting enzyme-2 level was statistically non-significant between the two groups (P-value = 0.13). who had recovered from a coronavirus infection for 3 months or more. Also, the bone mineral density of Post COVID-19 patients that was measured by DEXA scan had a highly significant T-score% when compared between the two groups.\u0000Conclusions:This research found that COVID-19 has an impact on the bone remodeling process, leading to osteopenia or osteoporosis, which may be identified by checking the blood levels of the bone biomarker BAP and the bone mineral density (by DEXA scan) at least three months following coronavirus recovery. This investigation also discovered that some of the individuals had osteopenia rather than osteoporosis.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43667802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-13DOI: 10.32007/jfacmedbagdad.6441959
Sajjad Mustafa Thamer, Mohammed Q. Yahya
Background: Lenalidomide is an immunomodulatory drug having notable anti-inflammatory, and anti-antineoplastic properties. Lenalidomide suppresses the production of pro-inflammatory cytokines that have been linked to a variety of hematologic malignancies. Lenalidomide enhances the immune system of the host by regulating T cell proliferation, which results in changes in inflammation that are related to the etiology of psoriasis. Objectives: The objectives of this study were to determine the efficacy of lenalidomide as an ointment in treating mouse models of psoriasis as well as how it may affect TNF-α levels in skin tissue in different experimental groups. Methods: The study was carried out between November 2021 and June 2022. 70 healthy male albino mice were randomly divided into 7 groups of 10 animals each. In groups (1, 2, 3, 4, 5 and 6), imiquimod produced psoriasis. Only imiquimod cream was administered to Group 1, after psoriasis induced, Clobetasol ointment was applied to Group 2, placebo ointment was applied to Group 3, and lenalidomide ointment (1%, 2%, and 3%) were applied to Groups (4, 5, and 6), respectively. Healthy mice were utilized as a comparative control in Group 7. SPSS was utilized for the statistical analysis of the data (version 26). Results: Following lenalidomide treatment, the psoriatic region improved. Lenalidomide's effectiveness to treat imiquimod-induced mouse psoriasis was explained by the difference in tissue levels of TNF-α between the examined groups. Conclusions: Findings suggest that different concentrations of lenalidomide ointment can improve mouse models of imiquimod-induced psoriasis. Histopathology and immunohistochemistry assays show that lenalidomide ointment was more effective and had no side effects that were associated with the use of the standard drugs.
{"title":"Effect of Lenalidomide Ointment on TNF-α Tissue Levels in Mice with Imiquimod-Induced Psoriasis.","authors":"Sajjad Mustafa Thamer, Mohammed Q. Yahya","doi":"10.32007/jfacmedbagdad.6441959","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441959","url":null,"abstract":"Background: Lenalidomide is an immunomodulatory drug having notable anti-inflammatory, and anti-antineoplastic properties. Lenalidomide suppresses the production of pro-inflammatory cytokines that have been linked to a variety of hematologic malignancies. Lenalidomide enhances the immune system of the host by regulating T cell proliferation, which results in changes in inflammation that are related to the etiology of psoriasis.\u0000Objectives: The objectives of this study were to determine the efficacy of lenalidomide as an ointment in treating mouse models of psoriasis as well as how it may affect TNF-α levels in skin tissue in different experimental groups.\u0000Methods: The study was carried out between November 2021 and June 2022. 70 healthy male albino mice were randomly divided into 7 groups of 10 animals each. In groups (1, 2, 3, 4, 5 and 6), imiquimod produced psoriasis. Only imiquimod cream was administered to Group 1, after psoriasis induced, Clobetasol ointment was applied to Group 2, placebo ointment was applied to Group 3, and lenalidomide ointment (1%, 2%, and 3%) were applied to Groups (4, 5, and 6), respectively. Healthy mice were utilized as a comparative control in Group 7. SPSS was utilized for the statistical analysis of the data (version 26).\u0000Results: Following lenalidomide treatment, the psoriatic region improved. Lenalidomide's effectiveness to treat imiquimod-induced mouse psoriasis was explained by the difference in tissue levels of TNF-α between the examined groups.\u0000Conclusions: Findings suggest that different concentrations of lenalidomide ointment can improve mouse models of imiquimod-induced psoriasis. Histopathology and immunohistochemistry assays show that lenalidomide ointment was more effective and had no side effects that were associated with the use of the standard drugs.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42241096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-13DOI: 10.32007/jfacmedbagdad.6441992
M. Al-Hadeethi
ِAbstract: Autonomic neuropathy, vasculogenic causes, endocrine deficit, drug-induced, psychosocial problems, or a combination of these causes might lead to Erectile dysfunction (ED). Aim: This study aimed to compare between pudendal neuropathy against limb neuropathy in patients with diabetics and complaining from Erectile dysfunction by considering the Electrophysiological studies. Methodology: 84 diabetic subjects were enrolled in this analytic cross-sectional study with an average age of 38.4 years presented with impotence. All of them were assessed by Electrophysiological studies using Bulbocavernosus induced Reflex to assess competence of pudendal nerve and other nerve studies to assess lower limbs nerve competences. Results: The results of assessing the pudendal nerve versus limb nerves revealed earlier involvement of the peripheral lower limb nerves in comparison with pudendal nerve. Conclusion: Electrophysiological assessment is a practical test which can be useful in identifying neurologic deficit of diabetic patients with erectile dysfunction.
{"title":"Pudendal nerve versus Lower Limb nerves electrophysiological abnormalities in diabetics with erectile dysfunction in Baghdad","authors":"M. Al-Hadeethi","doi":"10.32007/jfacmedbagdad.6441992","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441992","url":null,"abstract":"ِAbstract: \u0000 \u0000Autonomic neuropathy, vasculogenic causes, endocrine deficit, drug-induced, psychosocial problems, or a combination of these causes might lead to Erectile dysfunction (ED). \u0000 \u0000Aim: \u0000 \u0000This study aimed to compare between pudendal neuropathy against limb neuropathy in patients with diabetics and complaining from Erectile dysfunction by considering the Electrophysiological studies. \u0000 \u0000Methodology: \u0000 \u000084 diabetic subjects were enrolled in this analytic cross-sectional study with an average age of 38.4 years presented with impotence. All of them were assessed by Electrophysiological studies using Bulbocavernosus induced Reflex to assess competence of pudendal nerve and other nerve studies to assess lower limbs nerve competences. \u0000 \u0000Results: \u0000 \u0000The results of assessing the pudendal nerve versus limb nerves revealed earlier involvement of the peripheral lower limb nerves in comparison with pudendal nerve. \u0000 \u0000Conclusion: \u0000 \u0000Electrophysiological assessment is a practical test which can be useful in identifying neurologic deficit of diabetic patients with erectile dysfunction.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49539975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-13DOI: 10.32007/jfacmedbagdad.6441972
Mohammed J. Al-Obaidi
Abstract: Background: Aggregatibacter actinomycetemcomitans is one of the most common periodontal pathogen that has a direct effect on periodontium. Diabetes and periodontitis considered as chronic diseases with a bidirectional relationship between them. Evidence has shown that the Node Like Receptor Pyrine-3 inflammasome, is crucial for both illnesses. Aim of study: This investigation was conducted to observe the association between bacterial load of A. actinomyctecomtans and serum level of NLRP3 inflammasome in periodontitis patient with and without type 2 DM and control group. Materials and Methods: This case-control study included 85 participants, whose ages ranged from (23-55) years. Split into three groups; the control group, which had a clinically and systemically healthy periodontium, and the two groups with periodontitis, one of which also had type 2 DM. Samples of the four most profound periodontal pockets were sampled for subgingival plaque, and from the gingival sulcus in the control group. The real-time (PCR) was utilized in this experiment. to quantify A. actinomyctecomtans DNA was isolated from samples of dental plaque. All subjects' serum was collected, and the concentration of NLRP3 was measured using an ELISA technique. Results: The results showed that the bacterial count was higher in two groups of patient than the control group, but there were no-significant differences. On the other hand, there was a significant correlation between the bacterial count and periodontal parameters in periodontitis with type 2 DM group, while in periodontitis group there was positive correlation with clinical attachment loss and bleeding on probing. A significant positive correlation also noticed between NLRP3 inflammasome and periodontal parameters in periodontitis patient with type2 DM. Regarding the group of periodontitis patients without systemic disease there was no significance correlation between inflammasome and clinical parameters. Finally, there is a non-significant correlation of A. actinomyctecomtans with inflammasome. Conclusions: A. actinomyctecomtans detection rate was strongly higher in patient groups compared to healthy subjects but statically non-significant. Moreover, the lack of correlation between A. actinomyctecomtans and the NLRP3 inflammasome indicates that NLRP3 activation is associated with inflammatory processes that are induced by a number of external factors, other than bacteria.
{"title":"Association between Aggregatibacter actinomy-cetemcomitans bacterial load and NLRP3 inflam-masome activation in periodontitis patients with Diabetes","authors":"Mohammed J. Al-Obaidi","doi":"10.32007/jfacmedbagdad.6441972","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441972","url":null,"abstract":"Abstract: Background: Aggregatibacter actinomycetemcomitans is one of the most common periodontal pathogen that has a direct effect on periodontium. Diabetes and periodontitis considered as chronic diseases with a bidirectional relationship between them. Evidence has shown that the Node Like Receptor Pyrine-3 inflammasome, is crucial for both illnesses. Aim of study: This investigation was conducted to observe the association between bacterial load of A. actinomyctecomtans and serum level of NLRP3 inflammasome in periodontitis patient with and without type 2 DM and control group. Materials and Methods: This case-control study included 85 participants, whose ages ranged from (23-55) years. Split into three groups; the control group, which had a clinically and systemically healthy periodontium, and the two groups with periodontitis, one of which also had type 2 DM. Samples of the four most profound periodontal pockets were sampled for subgingival plaque, and from the gingival sulcus in the control group. The real-time (PCR) was utilized in this experiment. to quantify A. actinomyctecomtans DNA was isolated from samples of dental plaque. All subjects' serum was collected, and the concentration of NLRP3 was measured using an ELISA technique. Results: The results showed that the bacterial count was higher in two groups of patient than the control group, but there were no-significant differences. On the other hand, there was a significant correlation between the bacterial count and periodontal parameters in periodontitis with type 2 DM group, while in periodontitis group there was positive correlation with clinical attachment loss and bleeding on probing. A significant positive correlation also noticed between NLRP3 inflammasome and periodontal parameters in periodontitis patient with type2 DM. Regarding the group of periodontitis patients without systemic disease there was no significance correlation between inflammasome and clinical parameters. Finally, there is a non-significant correlation of A. actinomyctecomtans with inflammasome. Conclusions: A. actinomyctecomtans detection rate was strongly higher in patient groups compared to healthy subjects but statically non-significant. Moreover, the lack of correlation between A. actinomyctecomtans and the NLRP3 inflammasome indicates that NLRP3 activation is associated with inflammatory processes that are induced by a number of external factors, other than bacteria.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43523452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-13DOI: 10.32007/jfacmedbagdad.6441969
Mohammed M. Kamil, M. Jabarah, Nizar A.l. Jasim
Background: Ankylosing spondylitis is a rare disease affecting people with hereditary factors. Its treatment includes life style modification and use of drugs such as the biologic agent infliximab or its biosimilar, CT-P13 infliximab. Despite their therapeutic usefulness, these agents are associated with a number of serious adverse effects such as immunogenicity. Objectives: The aim of current study was to investigate if immunogenicity of the biosimilar CT-P13 infliximab or the original infliximab, in Iraqi patients with Ankylosing spondylitis, is affected by any of the patients’ demographic characteristics. Methods: A retrospective open-label study was conducted from December 2021 to March 2022 at the Rheumatology Unit, Baghdad Teaching Hospital/Medical City, Baghdad. Forty-four patients were taking Infliximab, and another 50 patients were taking CT-P13, both at a dose of 5mg/kg for 3 months prior to recruitment in current study. Disease activity was assessed by ASDAS-CRP score while antibodies and C-reactive protein were tested by Enzyme-Linked Immunosorbent Assay technique. Statistical analyses were performed using SPSS statistical package for Social Sciences version 20.0. The level of significance was considered at P<0.05. Results: There was non-significant correlation between anti-infliximab antibodies and demographic data of patients (P>0.05). Similar data were reported regarding the biosimilar CT-P13 infliximab except for smoking and disease activity which exhibited significant correlation with development of anti-CT-P13 antibodies (P<0.05). Conclusion: Immunogenicity of the biosimilar CT-P13 infliximab, but not that of the original Infliximab, may be influenced by demographic characteristics or disease activity in patients with ankylosing spondylitis.
{"title":"Immunogenicity of the biosimilar CT-P13 infliximab or the original infliximab in Iraqi patients with Ankylosing spondylitis does not correlate with their demographic characteristics","authors":"Mohammed M. Kamil, M. Jabarah, Nizar A.l. Jasim","doi":"10.32007/jfacmedbagdad.6441969","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441969","url":null,"abstract":"Background: Ankylosing spondylitis is a rare disease affecting people with hereditary factors. Its treatment includes life style modification and use of drugs such as the biologic agent infliximab or its biosimilar, CT-P13 infliximab. Despite their therapeutic usefulness, these agents are associated with a number of serious adverse effects such as immunogenicity.\u0000Objectives: The aim of current study was to investigate if immunogenicity of the biosimilar CT-P13 infliximab or the original infliximab, in Iraqi patients with Ankylosing spondylitis, is affected by any of the patients’ demographic characteristics.\u0000Methods: A retrospective open-label study was conducted from December 2021 to March 2022 at the Rheumatology Unit, Baghdad Teaching Hospital/Medical City, Baghdad. Forty-four patients were taking Infliximab, and another 50 patients were taking CT-P13, both at a dose of 5mg/kg for 3 months prior to recruitment in current study. Disease activity was assessed by ASDAS-CRP score while antibodies and C-reactive protein were tested by Enzyme-Linked Immunosorbent Assay technique. Statistical analyses were performed using SPSS statistical package for Social Sciences version 20.0. The level of significance was considered at P<0.05.\u0000Results: There was non-significant correlation between anti-infliximab antibodies and demographic data of patients (P>0.05). Similar data were reported regarding the biosimilar CT-P13 infliximab except for smoking and disease activity which exhibited significant correlation with development of anti-CT-P13 antibodies (P<0.05).\u0000Conclusion: Immunogenicity of the biosimilar CT-P13 infliximab, but not that of the original Infliximab, may be influenced by demographic characteristics or disease activity in patients with ankylosing spondylitis.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44066455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-13DOI: 10.32007/jfacmedbagdad.6441976
Huda Mozer AbdAlraheem, R. D. Aljanabi
Background: Since declaring coronavirus disease 19 as a pandemic by the World Health Organization, a great concern was directed toward pregnant women and their fetuses. Despite the substantial impact of COVID-19 disease on pregnancy, there is a scarcity of national researches discussing this important issue. Objectives: To study the relationship between peripheral blood abnormalities and COVID-19 in pregnant women. Patients and methods: A case control study was conducted in the labour wards of Baghdad Teaching Hospital in the Medical complex / Baghdad /Iraq during the period from 1st of February till 31st of July, 2021. Fifty pregnant women diagnosed with COVID-19 disease were compared to 50 healthy pregnant women as controls. The pregnant women enrolled in the study were tested by COVID-19-Reverse transcription RT-PCR test upon admission to hospital. The confirmation of COVID-19 diagnosis was done according to the Iraqi guidelines approved by the Iraqi Ministry of Health. Results: Dyspnea was a significant clinical presentation of pregnant women with COVID-19 disease. Those women had abnormal white blood cell count, lymphocytopenia, high neutrophil to lymphocyte ratio, high platelets to lymphocyte ratio and mild to moderate anemia which were significant when compared to controls. The maternal and neonatal morbidity and mortality rates were higher among pregnant women with COVID-19 disease. Abnormalities in peripheral blood system parameters like lymphocyte count, neutrophils count, platelets count and hemoglobin level were predictors of maternal morbidity and mortality. Conclusions: The clinical presentations and hematological abnormalities are useful in the diagnosis of COVID-19 disease in pregnant women and may be used as predictors of maternal and neonatal morbidity and mortality.
{"title":"Hematologic abnormalities and pregnancy outcomes in pregnant women with COVID-19","authors":"Huda Mozer AbdAlraheem, R. D. Aljanabi","doi":"10.32007/jfacmedbagdad.6441976","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441976","url":null,"abstract":"Background: Since declaring coronavirus disease 19 as a pandemic by the World Health Organization, a great concern was directed toward pregnant women and their fetuses. Despite the substantial impact of COVID-19 disease on pregnancy, there is a scarcity of national researches discussing this important issue. \u0000Objectives: To study the relationship between peripheral blood abnormalities and COVID-19 in pregnant women.\u0000Patients and methods: A case control study was conducted in the labour wards of Baghdad Teaching Hospital in the Medical complex / Baghdad /Iraq during the period from 1st of February till 31st of July, 2021. Fifty pregnant women diagnosed with COVID-19 disease were compared to 50 healthy pregnant women as controls. The pregnant women enrolled in the study were tested by COVID-19-Reverse transcription RT-PCR test upon admission to hospital. The confirmation of COVID-19 diagnosis was done according to the Iraqi guidelines approved by the Iraqi Ministry of Health.\u0000Results: Dyspnea was a significant clinical presentation of pregnant women with COVID-19 disease. Those women had abnormal white blood cell count, lymphocytopenia, high neutrophil to lymphocyte ratio, high platelets to lymphocyte ratio and mild to moderate anemia which were significant when compared to controls. The maternal and neonatal morbidity and mortality rates were higher among pregnant women with COVID-19 disease. Abnormalities in peripheral blood system parameters like lymphocyte count, neutrophils count, platelets count and hemoglobin level were predictors of maternal morbidity and mortality.\u0000Conclusions: The clinical presentations and hematological abnormalities are useful in the diagnosis of COVID-19 disease in pregnant women and may be used as predictors of maternal and neonatal morbidity and mortality.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49316722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-13DOI: 10.32007/jfacmedbagdad.6441948
Muhammed Whaeeb Salman Al-Obaidy, Nadhema Bahaa Hussein Wetwet, H. Kerbel, A. Baay
Abstract Background Stathmin1 (also known as metablastin) is a major microtubule-depolymerizing protein that involved in cell cycle progression and cell motility. Stathmin1 has been found to be up-regulated in some cancers and correlated with cell differentiation and proliferation. Stathmin1 is a major cytosolic phosphoprotein that regulates microtubule dynamics and is associated with malignant phenotypes in various cancers, including non-small cell lung cancer. Objective To evaluate the role of Immunohistochemical expression of stathmin1 in non-small lung carcinoma and its correlation to different prognostic factors or parameters. Materials and methods This retrospective study carried on formalin fixed paraffin embedded surgical specimens of lung tumors Applying the Immunohistochemical techniques by using the primary antibodies to stathmin1, statistical analysis done and assessment of correlation with different clinical and pathological parameters measured. Results Fifty cases of Non-small lung carcinomas that 42% adenocarcinoma,44% squamous cell carcinoma 10% adenosequamous and 4% non-small lung carcinoma 84 % were Stathmin-1 positive. No significant correlation between Stathmin-1 expression with age and gender of patients but Stathmin-1 expression were correlated with parameters including type and grade of tumor. High expression was noted in poorly differentiated tumors. Conclusions Measurement of stathmin1 level may be a beneficial prognostic biomarker for non-small lung tumors especially those of poorly differentiated tumors Stathmin1 expression in non-small cell lung carcinoma significantly correlated with poor tumor differentiation and could be considered as independent prognostic factor.
{"title":"Immunohistochemical Study of Stathmin-1 as A Prognostic factor In Non-small cell lung carcinoma","authors":"Muhammed Whaeeb Salman Al-Obaidy, Nadhema Bahaa Hussein Wetwet, H. Kerbel, A. Baay","doi":"10.32007/jfacmedbagdad.6441948","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441948","url":null,"abstract":"Abstract \u0000 \u0000Background \u0000Stathmin1 (also known as metablastin) is a major microtubule-depolymerizing protein that involved in cell cycle progression and cell motility. \u0000 Stathmin1 has been found to be up-regulated in some cancers and correlated with cell differentiation and proliferation. \u0000Stathmin1 is a major cytosolic phosphoprotein that regulates microtubule dynamics and is associated with malignant phenotypes in various cancers, including non-small cell lung cancer. \u0000 \u0000Objective \u0000 To evaluate the role of Immunohistochemical expression of stathmin1 in non-small lung carcinoma and its correlation to different prognostic factors or parameters. \u0000 \u0000Materials and methods \u0000This retrospective study carried on formalin fixed paraffin embedded surgical specimens of lung tumors Applying the Immunohistochemical techniques by using the primary antibodies to stathmin1, statistical analysis done and assessment of correlation with different clinical and pathological parameters measured. \u0000 \u0000 Results \u0000Fifty cases of Non-small lung carcinomas that 42% adenocarcinoma,44% squamous cell carcinoma 10% adenosequamous and 4% non-small lung carcinoma 84 % were Stathmin-1 positive. \u0000 No significant correlation between Stathmin-1 expression with age and gender of patients but Stathmin-1 expression were correlated with parameters including type and grade of tumor. \u0000High expression was noted in poorly differentiated tumors. \u0000 \u0000Conclusions \u0000Measurement of stathmin1 level may be a beneficial prognostic biomarker for non-small lung tumors especially those of poorly differentiated tumors \u0000Stathmin1 expression in non-small cell lung carcinoma significantly correlated with poor tumor differentiation and could be considered as independent prognostic factor.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48506527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-13DOI: 10.32007/jfacmedbagdad.6442009
Tuqa H. Qasim, Mazin J. Ibraheem, M. Jabarah
Background: Sorafenib is an oral multikinase inhibitor which has been given approval by the United States Food and Drug Administration for the treatment of patients diagnosed with hepatocellular carcinoma and advanced renal cell carcinoma . However, measuring quality of life and patient-reported symptoms may provide further information for evaluating and comparing treatment efficacy and toxicity profiles during cancer treatment. Despite the critical importance of patients' quality of life while receiving anticancer treatment, neither Iraqi patients undergoing anti-cancer medications in general nor those receiving Sorafenib in particular had any published data evaluating this important parameter. Objectives: The study aimed to assess the quality of life of Sorafenib-treated Iraqi patients diagnosed with hepatocellular carcinoma. Methods: A prospective, cross-sectional study was performed at the oncology clinic of (Oncology Teaching Hospital, Al-Amal Hospital and Al -Imamein Al- Kadhimein Medical City in Baghdad, Iraq) during the period from November 2021 to July 2022. Patients were enrolled in current study by using a convenient sampling method. Assessment of quality of life was performed using a questionnaire from the “European Organization for Research and Treatment of Cancer”. Statistical analyses were performed using statistical package for Social Sciences. Student’s t-test and ANOVA test were used to compare categorical data. P value of <0.05 was considered statistically significant. Results: The present study included 52 patients in total. Of the latter, 90.4% experienced fatigue, making it the most frequent adverse event, followed by anorexia, anemia, nausea, diarrhea and vomiting (71.2%, 67.3%, 65.4%, 59.6%, 26.9%, respectively). In spite of that, some participants had a good quality of life while others did not. Conclusion: Patients with hepatocellular carcinoma on sorafenib treatment have variable quality of the life. The latter is significantly affected by patients’ sociodemographic characteristics and treatment-related adverse events.
{"title":"Impact of sociodemographic characteristics and drug-related side effects on quality of life of patients with hepatocellular carcinoma receiving sorafenib treatment in Iraqi hospitals","authors":"Tuqa H. Qasim, Mazin J. Ibraheem, M. Jabarah","doi":"10.32007/jfacmedbagdad.6442009","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6442009","url":null,"abstract":"Background: Sorafenib is an oral multikinase inhibitor which has been given approval by the United States Food and Drug Administration for the treatment of patients diagnosed with hepatocellular carcinoma and advanced renal cell carcinoma . However, measuring quality of life and patient-reported symptoms may provide further information for evaluating and comparing treatment efficacy and toxicity profiles during cancer treatment. Despite the critical importance of patients' quality of life while receiving anticancer treatment, neither Iraqi patients undergoing anti-cancer medications in general nor those receiving Sorafenib in particular had any published data evaluating this important parameter.\u0000Objectives: The study aimed to assess the quality of life of Sorafenib-treated Iraqi patients diagnosed with hepatocellular carcinoma.\u0000Methods: A prospective, cross-sectional study was performed at the oncology clinic of (Oncology Teaching Hospital, Al-Amal Hospital and Al -Imamein Al- Kadhimein Medical City in Baghdad, Iraq) during the period from November 2021 to July 2022. Patients were enrolled in current study by using a convenient sampling method. Assessment of quality of life was performed using a questionnaire from the “European Organization for Research and Treatment of Cancer”. Statistical analyses were performed using statistical package for Social Sciences. Student’s t-test and ANOVA test were used to compare categorical data. P value of <0.05 was considered statistically significant.\u0000Results: The present study included 52 patients in total. Of the latter, 90.4% experienced fatigue, making it the most frequent adverse event, followed by anorexia, anemia, nausea, diarrhea and vomiting (71.2%, 67.3%, 65.4%, 59.6%, 26.9%, respectively). In spite of that, some participants had a good quality of life while others did not.\u0000Conclusion: Patients with hepatocellular carcinoma on sorafenib treatment have variable quality of the life. The latter is significantly affected by patients’ sociodemographic characteristics and treatment-related adverse events.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42550414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-13DOI: 10.32007/jfacmedbagdad.6441985
Noor Ibraheem ahmed ibraheem, Rawaa H. Ali, Mohammed B. Ismail
Background: Bladder cancer is among the most prevalent cancers worldwide, with 549,393 new cases reported in 2018. Approximately 3% of all new cancer diagnoses and 2.1% of all cancer deaths are due to urinary bladder cancer. Objectives: This study aims to explore the efficiency of renal system functions as indicated by renal function tests and electrolyte levels among bladder cancer patients. Methods: All patients in this case-control study were recruited from Ghazi Al-Hariri Hospital for surgical specialties in Baghdad during the period from December 2021 to June 2022. A total of 100 individuals were enrolled in this study and divided into two groups. The first group included 50 patients with an age range of (16-79) years. All patients were first diagnosed and investigated with a bladder mass by transurethral resection of bladder tumor (TURBT) and sent to the histopathological examination for biopsy of bladder lesion. The second group included 50 healthy individuals. Results: The results of the present study showed that all renal function tests and serum electrolyte levels were in the upper limit or within the normal range, although some of these levels were significantly different between patients and controls. Conclusion: All renal function tests were within the upper limits of the normal range as most of the bladder tumors were low-grade small-sized masses.
背景：癌症是全球最常见的癌症之一，2018年报告了549393例新病例。大约3%的癌症新诊断和2.1%的癌症死亡是由癌症引起的。目的：本研究旨在探讨癌症患者肾功能测试和电解质水平对肾系统功能的影响。方法：本病例对照研究中的所有患者均于2021年12月至2022年6月期间从巴格达Ghazi Al Hariri医院接受外科专科治疗。本研究共招募了100名个体，并将其分为两组。第一组包括50名患者，年龄范围为（16-79）岁。所有患者首先通过经尿道膀胱肿瘤切除术（TURBT）诊断和调查膀胱肿块，并接受组织病理学检查，进行膀胱病变活检。第二组包括50名健康人。结果：本研究结果显示，所有肾功能测试和血清电解质水平均在上限或正常范围内，尽管其中一些水平在患者和对照组之间存在显著差异。结论：所有肾功能检查均在正常范围的上限内，因为大多数膀胱肿瘤都是低级别的小肿块。
{"title":"Kidney functions and electrolyte disturbance among Iraqi patients with bladder cancer","authors":"Noor Ibraheem ahmed ibraheem, Rawaa H. Ali, Mohammed B. Ismail","doi":"10.32007/jfacmedbagdad.6441985","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441985","url":null,"abstract":"Background: Bladder cancer is among the most prevalent cancers worldwide, with 549,393 new cases reported in 2018. Approximately 3% of all new cancer diagnoses and 2.1% of all cancer deaths are due to urinary bladder cancer.\u0000Objectives: This study aims to explore the efficiency of renal system functions as indicated by renal function tests and electrolyte levels among bladder cancer patients.\u0000Methods: All patients in this case-control study were recruited from Ghazi Al-Hariri Hospital for surgical specialties in Baghdad during the period from December 2021 to June 2022. A total of 100 individuals were enrolled in this study and divided into two groups. The first group included 50 patients with an age range of (16-79) years. All patients were first diagnosed and investigated with a bladder mass by transurethral resection of bladder tumor (TURBT) and sent to the histopathological examination for biopsy of bladder lesion. The second group included 50 healthy individuals.\u0000Results: The results of the present study showed that all renal function tests and serum electrolyte levels were in the upper limit or within the normal range, although some of these levels were significantly different between patients and controls.\u0000Conclusion: All renal function tests were within the upper limits of the normal range as most of the bladder tumors were low-grade small-sized masses.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49219281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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