Pub Date : 2023-01-01DOI: 10.5937/scriptamed54-45970
Rajko Igić
Alexander Borodin, a member of the Mighty Five composers, is presented. As an artist, due to his main compositions, Borodin got world fame. In contrast, his medical and scientific works and educational innovations are practically forgotten. We consider whether there is an objective way to compare the value of scientific and artistic creativity, including musical composing.
{"title":"Alexander Borodin's contributions to arts and sciences","authors":"Rajko Igić","doi":"10.5937/scriptamed54-45970","DOIUrl":"https://doi.org/10.5937/scriptamed54-45970","url":null,"abstract":"Alexander Borodin, a member of the Mighty Five composers, is presented. As an artist, due to his main compositions, Borodin got world fame. In contrast, his medical and scientific works and educational innovations are practically forgotten. We consider whether there is an objective way to compare the value of scientific and artistic creativity, including musical composing.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135839752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5937/scriptamed54-45176
Saghar Ghorbani, Mostafa Saadat
Background/Aim: Age-related macular degeneration (AMD) is major reason of blindness in human. Plasminogen is converted to plasmin by tissue plasminogen activator protein (PLAT, formerly known as TPA). A polymorphism in intron 8 of PLAT gene has been reported, either with (insertion) or without (deletion) a 311 bp Alu sequence. This polymorphism is associated with plasma levels of glycoprotein t-PA. t-PA is expressed in the retina and is involved in the development of the eye. It can be hypothesised that the PLAT polymorphism may be correlated with AMD. Therefore, the current study was conducted. Methods: A total of 121 AMD patients and 108 healthy subjects were included in the study. Genotyping was performed by PCR. The strength of the association between AMD and polymorphism was expressed by estimating the odds ratio (OR). Results: There was a significant relationship between the Del/Del genotype and susceptibility to AMD (OR = 2.25, 95 % CI = 1.07-4.69, p = 0.031). After adjusting for various factors such as age, smoking habit and workplace, a similar relationship was obtained (OR = 2.51, 95 % CI = 1.01-6.23, p = 0.049). Conclusions: The homozygosity of the Del allele was found to increase the susceptibility to AMD. This polymorphism may contribute to the risk of AMD in population.
背景/目的:老年性黄斑变性(AMD)是人类致盲的主要原因。纤溶酶原通过组织纤溶酶原激活蛋白(PLAT，以前称为TPA)转化为纤溶酶。据报道，PLAT基因8内含子存在311bp的Alu序列(插入)或不存在(缺失)多态性。这种多态性与血浆糖蛋白t-PA水平有关。t-PA在视网膜中表达，并参与眼睛的发育。可以推测PLAT多态性可能与AMD相关。因此，进行了本研究。方法:选取121例AMD患者和108名健康对照者作为研究对象。采用PCR进行基因分型。通过估计比值比(OR)来表达AMD与多态性之间的关联强度。结果:Del/Del基因型与AMD易感性有显著相关性(OR = 2.25, 95% CI = 1.07 ~ 4.69, p = 0.031)。在调整了年龄、吸烟习惯和工作场所等各种因素后，得到了类似的关系(OR = 2.51, 95% CI = 1.01-6.23, p = 0.049)。结论:发现Del等位基因的纯合性增加了AMD的易感性。这种多态性可能与人群发生AMD的风险有关。
{"title":"Association between Alu insertion/deletion polymorphism in intron 8 of human tissue plasminogen activator gene (PLAT) and risk of age-related macular degeneration","authors":"Saghar Ghorbani, Mostafa Saadat","doi":"10.5937/scriptamed54-45176","DOIUrl":"https://doi.org/10.5937/scriptamed54-45176","url":null,"abstract":"Background/Aim: Age-related macular degeneration (AMD) is major reason of blindness in human. Plasminogen is converted to plasmin by tissue plasminogen activator protein (PLAT, formerly known as TPA). A polymorphism in intron 8 of PLAT gene has been reported, either with (insertion) or without (deletion) a 311 bp Alu sequence. This polymorphism is associated with plasma levels of glycoprotein t-PA. t-PA is expressed in the retina and is involved in the development of the eye. It can be hypothesised that the PLAT polymorphism may be correlated with AMD. Therefore, the current study was conducted. Methods: A total of 121 AMD patients and 108 healthy subjects were included in the study. Genotyping was performed by PCR. The strength of the association between AMD and polymorphism was expressed by estimating the odds ratio (OR). Results: There was a significant relationship between the Del/Del genotype and susceptibility to AMD (OR = 2.25, 95 % CI = 1.07-4.69, p = 0.031). After adjusting for various factors such as age, smoking habit and workplace, a similar relationship was obtained (OR = 2.51, 95 % CI = 1.01-6.23, p = 0.049). Conclusions: The homozygosity of the Del allele was found to increase the susceptibility to AMD. This polymorphism may contribute to the risk of AMD in population.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135839757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5937/scriptamed54-44761
Nikolina Marić, Aleksandar Đuričin, Radojka Jokšić-Mazinjanin, Milica Odavić, Dane Tabš, Tamara Nocmartini, Velibor Vasović
Background/Aim: Acute myocardial infarction (AMI) is a consequence of complete coronary artery occlusion. There is a considerable seasonal variation in the incidence of AMI. The aim of the study was to establish a circadian and seasonal pattern of AMI. Methods: A retrospective observational study was conducted, using the database of the Institute of Emergency Medical Service of the City of Novi Sad. The study included 982 patients, both male and female, diagnosed with AMI (I.21 - ICD-10 code) in the period between 15 March 2018 and 14 March 2022. Data were classified according to the time of the day, days of the week, quarters and months. Data were analysed by using descriptive statistical methods, Mann-Whitney U test, Chi-squared test and Fisher's exact test. Results: AMI most frequently occurred between 6 am and 2 pm (389; 39.6 %). A statistically significant incidence of AMI was calculated for the periods between 6 am and 2 pm (ch2 = 39.69; p < 0.001) and between 2 pm and 10 pm (ch2 = 28.06; p < 0.001). Most cases of AMI were noted on Monday (153; 15.6 %) and in January (93; 9.5 %). The highest incidence of AMI was in the period between 15 March 2021 and 14 March 2022 (304; 31.0 %), while the lowest incidence was noted between 15 March 2019 and 14 March 2020 (190; 19.3 %). Conclusion: Circadian, seasonal and annual rhythm may have a significant impact on the incidence of AMI. This fact can have an important role in the prevention, timely recognition and adequate treatment of acute coronary disease.
{"title":"Influence of circadian rhythms and seasonal and annual variations on acute myocardial infarction incidence","authors":"Nikolina Marić, Aleksandar Đuričin, Radojka Jokšić-Mazinjanin, Milica Odavić, Dane Tabš, Tamara Nocmartini, Velibor Vasović","doi":"10.5937/scriptamed54-44761","DOIUrl":"https://doi.org/10.5937/scriptamed54-44761","url":null,"abstract":"Background/Aim: Acute myocardial infarction (AMI) is a consequence of complete coronary artery occlusion. There is a considerable seasonal variation in the incidence of AMI. The aim of the study was to establish a circadian and seasonal pattern of AMI. Methods: A retrospective observational study was conducted, using the database of the Institute of Emergency Medical Service of the City of Novi Sad. The study included 982 patients, both male and female, diagnosed with AMI (I.21 - ICD-10 code) in the period between 15 March 2018 and 14 March 2022. Data were classified according to the time of the day, days of the week, quarters and months. Data were analysed by using descriptive statistical methods, Mann-Whitney U test, Chi-squared test and Fisher's exact test. Results: AMI most frequently occurred between 6 am and 2 pm (389; 39.6 %). A statistically significant incidence of AMI was calculated for the periods between 6 am and 2 pm (ch2 = 39.69; p < 0.001) and between 2 pm and 10 pm (ch2 = 28.06; p < 0.001). Most cases of AMI were noted on Monday (153; 15.6 %) and in January (93; 9.5 %). The highest incidence of AMI was in the period between 15 March 2021 and 14 March 2022 (304; 31.0 %), while the lowest incidence was noted between 15 March 2019 and 14 March 2020 (190; 19.3 %). Conclusion: Circadian, seasonal and annual rhythm may have a significant impact on the incidence of AMI. This fact can have an important role in the prevention, timely recognition and adequate treatment of acute coronary disease.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135843062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5937/scriptamed54-44973
Okta Dewi, Dewi Zilda, Maya Rakhmawatie, Amin Samiasih, Stalis Ethica
Background/Aim: Cardiovascular diseases (CVDs) are the primary noncommunicable disease at the global level due to abnormal platelet aggregation by fibrin forming clots in blood vessels called thrombus. The search for thrombolytic drugs is largely carried out to treat thrombosis. Crude extract and dialysate protease of Bacillus thuringiensis HSFI-12 is known to have thrombolytic activity in vitro. The in vivo thrombolytic activity evaluation of concentrated protease of the bacterium is yet to be done. This study aimed to evaluate in vivo thrombolytic activity of concentrated protease produced by ultrafiltration of crude B thuringiensis HSFI-12 protease using Rattus norvegicus as animal model. Methods: Carrageenan was used as thrombosis induction agent in rats. Intravenous injection of B thuringiensis HSFI-12 concentrated protease doses of 75, 150, 300, 600 µg/kg body weight (BW) was administered to rats, then induction of carrageenan was given intravenously to the rats' tails 30 min after injection of B thuringiensis HSFI-12 protease concentrate. The average length of the infarct area in the tail of the rat was shorter in the rats that were given various doses of B thuringiensis HSFI-12 protease concentrate compared to the negative control (rats induced by carrageenan 20 mg/kg BW). Results: The PT examination results showed a prolonged PT time at 300 µg/kg BW dose, while there was at risk of bleeding at 600 µg/kg BW dose. The activated partial thromboplastin time (aPTT) examination results showed that time elongation beyond the normal range did not occur in rats after treatment. The amount leukocytes (WBC) and erythrocytes (RBC) after treatment were within the normal range indicating that they did not affect the haemostasis mechanism, while the platelet count (PLT) assay showed decrease in the number of platelets (thrombocytopenia). However, after treatment the number of platelets (PLT) showed a positive response as seen from an increase in values close to normal range. As conclusion, induction of carrageenan conducted had successfully caused thrombosis in R norvegicus' tail used as the thrombosis model. Conclusion: Concentrated protease of B thuringiensis HSFI-12 showed in vivo antithrombotic potential with an effective dose of based on PT, aPTT and blood count evaluation at 150 µg/kg BW.
{"title":"In vivo antithrombotic potential of protease from Bacillus thuringiensis HSFI-12","authors":"Okta Dewi, Dewi Zilda, Maya Rakhmawatie, Amin Samiasih, Stalis Ethica","doi":"10.5937/scriptamed54-44973","DOIUrl":"https://doi.org/10.5937/scriptamed54-44973","url":null,"abstract":"Background/Aim: Cardiovascular diseases (CVDs) are the primary noncommunicable disease at the global level due to abnormal platelet aggregation by fibrin forming clots in blood vessels called thrombus. The search for thrombolytic drugs is largely carried out to treat thrombosis. Crude extract and dialysate protease of Bacillus thuringiensis HSFI-12 is known to have thrombolytic activity in vitro. The in vivo thrombolytic activity evaluation of concentrated protease of the bacterium is yet to be done. This study aimed to evaluate in vivo thrombolytic activity of concentrated protease produced by ultrafiltration of crude B thuringiensis HSFI-12 protease using Rattus norvegicus as animal model. Methods: Carrageenan was used as thrombosis induction agent in rats. Intravenous injection of B thuringiensis HSFI-12 concentrated protease doses of 75, 150, 300, 600 µg/kg body weight (BW) was administered to rats, then induction of carrageenan was given intravenously to the rats' tails 30 min after injection of B thuringiensis HSFI-12 protease concentrate. The average length of the infarct area in the tail of the rat was shorter in the rats that were given various doses of B thuringiensis HSFI-12 protease concentrate compared to the negative control (rats induced by carrageenan 20 mg/kg BW). Results: The PT examination results showed a prolonged PT time at 300 µg/kg BW dose, while there was at risk of bleeding at 600 µg/kg BW dose. The activated partial thromboplastin time (aPTT) examination results showed that time elongation beyond the normal range did not occur in rats after treatment. The amount leukocytes (WBC) and erythrocytes (RBC) after treatment were within the normal range indicating that they did not affect the haemostasis mechanism, while the platelet count (PLT) assay showed decrease in the number of platelets (thrombocytopenia). However, after treatment the number of platelets (PLT) showed a positive response as seen from an increase in values close to normal range. As conclusion, induction of carrageenan conducted had successfully caused thrombosis in R norvegicus' tail used as the thrombosis model. Conclusion: Concentrated protease of B thuringiensis HSFI-12 showed in vivo antithrombotic potential with an effective dose of based on PT, aPTT and blood count evaluation at 150 µg/kg BW.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135843633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5937/scriptamed54-42580
A. Samiasih, K. Khoiriyah, Ethica Norma, Sulistyaningtyas Rahmawati, Satriya Pranata, Vanchapo Rino
Background/Aim: Flavonoids, tannins, saponins and polyphenols in yellow kepok banana (Musa x paradisiaca L. var. kepok) peel potentially could be a solution for peptic ulcer prevention. This study aimed to prove the efficacy of kepok banana peel extract as gastroprotective by analysing the number of gastric ulcers and markers of oxidative stress - malondialdehyde (MDA) and nitric oxide (NO). Methods: The study was performed on 33 female Wistar rats aged 3-4 months, weighed 100-250 g. Rats were divided into 3 groups: Musa Paradisiaca Var Kepok 1 (MPVK1) treatment group, Musa Paradisiaca Var Kepok 2 (MPVK2) and control group (K). In MPVK1 kepok banana peel extract at a dose of 80 mg / 200 g body weight (BW) was given and the MPVK2 group dose was 160 mg / 200 g BW. The gastritis induction was performed by using 5 % acetylsalicylic acid at a dose of 1500 mg/kg BW. MDA examination by HPLC method, NO examination by ELISA method and macroscopic examination by counting the number of ulcers on the gastric mucosa was performed. Results: The results showed that the lowest average MDA level, as well as the highest average NO level was in the MPVK2 group 3.27 and 286.17, respectively. The highest mean number of ulcers was in the control group 3.55. By analysing all the results it can be concluded that there is a significant difference in the average levels of MDA (p = 0.013), NO (p < 0.001) and the number of ulcers (p < 0.001) in the three groups. Conclusion: Banana peel extract was proven to be effective as a gastroprotective through markers of MDA, NO and the number of ulcers in Wistar rats.
{"title":"The gastroprotective role of yellow kepok Banana (Musa x Paradisiaca L. Var. Kepok) peel extract and influence on markers of oxidative stress: Malondialdehyde and nitric oxide","authors":"A. Samiasih, K. Khoiriyah, Ethica Norma, Sulistyaningtyas Rahmawati, Satriya Pranata, Vanchapo Rino","doi":"10.5937/scriptamed54-42580","DOIUrl":"https://doi.org/10.5937/scriptamed54-42580","url":null,"abstract":"Background/Aim: Flavonoids, tannins, saponins and polyphenols in yellow kepok banana (Musa x paradisiaca L. var. kepok) peel potentially could be a solution for peptic ulcer prevention. This study aimed to prove the efficacy of kepok banana peel extract as gastroprotective by analysing the number of gastric ulcers and markers of oxidative stress - malondialdehyde (MDA) and nitric oxide (NO). Methods: The study was performed on 33 female Wistar rats aged 3-4 months, weighed 100-250 g. Rats were divided into 3 groups: Musa Paradisiaca Var Kepok 1 (MPVK1) treatment group, Musa Paradisiaca Var Kepok 2 (MPVK2) and control group (K). In MPVK1 kepok banana peel extract at a dose of 80 mg / 200 g body weight (BW) was given and the MPVK2 group dose was 160 mg / 200 g BW. The gastritis induction was performed by using 5 % acetylsalicylic acid at a dose of 1500 mg/kg BW. MDA examination by HPLC method, NO examination by ELISA method and macroscopic examination by counting the number of ulcers on the gastric mucosa was performed. Results: The results showed that the lowest average MDA level, as well as the highest average NO level was in the MPVK2 group 3.27 and 286.17, respectively. The highest mean number of ulcers was in the control group 3.55. By analysing all the results it can be concluded that there is a significant difference in the average levels of MDA (p = 0.013), NO (p < 0.001) and the number of ulcers (p < 0.001) in the three groups. Conclusion: Banana peel extract was proven to be effective as a gastroprotective through markers of MDA, NO and the number of ulcers in Wistar rats.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83943519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5937/scriptamed54-42564
Enes Zogic, Kemal Alihodžić, Demir Toković, Aldin Nicević, Džemail Detanac
Necrotising fasciitis is a rare and severe disease, acute infection, often life-threatening, characterised by rapid and progressive spread through the subcutaneous tissue and superficial fascia. It can occur on any part of the body, mostly affecting the perineum, limbs and abdominal wall. A 76-year-old male patient with the development of lower limb necrotising fasciitis after a vascular procedure femoral-popliteal bypass, performed due to chronic ischaemia is presented. Patient previously had several different vascular procedures on other blood vessels, with diabetes and cardiovascular disease as leading comorbidities. Treatment included urgent surgical necrotomy, with all measures of conservative treatment. During the treatment, there was no need for a new vascular procedure, arterial flow was preserved. It is necessary to constantly remind surgeons about this rare but life-threatening disease so that they can recognise it in time and adequately treat it.
{"title":"Postoperative necrotising fasciitis of the lower limb as an unexpected complication of vascular surgery procedure: Case report","authors":"Enes Zogic, Kemal Alihodžić, Demir Toković, Aldin Nicević, Džemail Detanac","doi":"10.5937/scriptamed54-42564","DOIUrl":"https://doi.org/10.5937/scriptamed54-42564","url":null,"abstract":"Necrotising fasciitis is a rare and severe disease, acute infection, often life-threatening, characterised by rapid and progressive spread through the subcutaneous tissue and superficial fascia. It can occur on any part of the body, mostly affecting the perineum, limbs and abdominal wall. A 76-year-old male patient with the development of lower limb necrotising fasciitis after a vascular procedure femoral-popliteal bypass, performed due to chronic ischaemia is presented. Patient previously had several different vascular procedures on other blood vessels, with diabetes and cardiovascular disease as leading comorbidities. Treatment included urgent surgical necrotomy, with all measures of conservative treatment. During the treatment, there was no need for a new vascular procedure, arterial flow was preserved. It is necessary to constantly remind surgeons about this rare but life-threatening disease so that they can recognise it in time and adequately treat it.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82000753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5937/scriptamed54-42967
Kopal Sharma, S. Jasuja, Monica Jain, Y. Singh
Background/Aim: Pharmacovigilance in oncology is imperative as antineoplastic drugs are two-edged swords whose irrational use can pose a major health problem and a needless financial burden on the patient. The aim of this study was to study the comprehensive safety profile of anti-neoplastic drugs used for treating oral cancers. Methods: This hospital-based prospective observational study was conducted at two premiers (a government and a private) tertiary care centres in North-Western India among newly diagnosed cases of oral cancers of both sexes between the ages of 20-70 years and requiring chemotherapy treatment. The prescribing pattern of chemotherapy drugs, associated adverse effects and potential risk factors for the development of adverse effects was studied. An adverse drug reaction (ADR) causality was assessed by the WHO-UMC algorithm and preventability by Schumock and Thornton's criteria. Univariate and multivariate logistic regression analyses were used to identify the predictors related to chemotherapy-induced adverse effects. Results: The data concerned 188 patients, of which 64.3 % developed chemotherapy-related adverse effects. Among the prescribed anti-neoplastic drugs, a combination of 5-Fluorouracil, Cisplatin and Paclitaxel regimen was associated with the majority (91.42 %) of the adverse effects. Alopecia was the most common adverse effect noted in 26.44 % of patients, followed by nausea and anaemia in 15.7 % and 9.9 % of patients, respectively. Independent predictors of chemotherapy-related adverse effects were site (Adjusted odds ratio [AOR] = 1.95; 95 % CI 1.04 - 3.62, p = 0.03), chemotherapy and radiotherapy treatment (AOR = 5.00; 95 % CI 2.62 - 9.53, p < 0.001), combination regimen of 5-Fluorouracil, Cisplatin and Paclitaxel (AOR = 8.68; 95 % CI 2.55 - 29.48, p = 0.001), associated comorbidities (AOR = 16.68; 95 % CI 2.45 - 28.34, p < 0.001). Causality assessment revealed most adverse effects (82.64 %) to be possible. Conclusion: The adverse effect varies with the type of regimen which is prescribed for the patient. Site of cancer, concomitant radiotherapy treatment and associated comorbidities were the identifiable risk factors for developing adverse effects. Onco-pharmacovigilance studies in the future will help to provide tailored treatment to patients and improve their quality of life.
背景/目的:抗肿瘤药物是一把双刃剑，不合理的使用不仅会给患者带来严重的健康问题，还会给患者带来不必要的经济负担。本研究的目的是研究用于治疗口腔癌的抗肿瘤药物的综合安全性。方法:这项以医院为基础的前瞻性观察性研究在印度西北部的两个三级医疗中心(一个政府和一个私人)进行，研究对象是年龄在20-70岁之间、需要化疗的男女口腔癌新诊断病例。研究化疗药物的处方模式、相关不良反应及不良反应发生的潜在危险因素。采用WHO-UMC算法评估药物不良反应(ADR)因果关系，采用Schumock和Thornton标准评估可预防性。单变量和多变量逻辑回归分析用于确定与化疗引起的不良反应相关的预测因素。结果:188例患者，64.3%发生化疗相关不良反应。在处方抗肿瘤药物中，5-氟尿嘧啶、顺铂、紫杉醇联合方案的不良反应最多(91.42%)。最常见的不良反应是脱发，占26.44%，其次是恶心和贫血，分别占15.7%和9.9%。化疗相关不良反应的独立预测因子为部位(校正优势比[AOR] = 1.95;95% CI 1.04 - 3.62, p = 0.03)，化疗和放疗治疗(AOR = 5.00;95% CI 2.62 ~ 9.53, p < 0.001)， 5-氟尿嘧啶、顺铂、紫杉醇联合用药方案(AOR = 8.68;95% CI 2.55 - 29.48, p = 0.001)，相关合并症(AOR = 16.68;95% CI 2.45 ~ 28.34, p < 0.001)。因果关系评价显示大多数不良反应(82.64%)是可能发生的。结论:不良反应随给药方案的不同而不同。癌症部位、伴随放射治疗和相关合并症是发生不良反应的可识别的危险因素。未来的肿瘤联合药物警戒研究将有助于为患者提供量身定制的治疗并改善他们的生活质量。
{"title":"Assessment of adverse drug reactions in oral cancer patients receiving chemotherapy treatment at tertiary care centres in North-Western India","authors":"Kopal Sharma, S. Jasuja, Monica Jain, Y. Singh","doi":"10.5937/scriptamed54-42967","DOIUrl":"https://doi.org/10.5937/scriptamed54-42967","url":null,"abstract":"Background/Aim: Pharmacovigilance in oncology is imperative as antineoplastic drugs are two-edged swords whose irrational use can pose a major health problem and a needless financial burden on the patient. The aim of this study was to study the comprehensive safety profile of anti-neoplastic drugs used for treating oral cancers. Methods: This hospital-based prospective observational study was conducted at two premiers (a government and a private) tertiary care centres in North-Western India among newly diagnosed cases of oral cancers of both sexes between the ages of 20-70 years and requiring chemotherapy treatment. The prescribing pattern of chemotherapy drugs, associated adverse effects and potential risk factors for the development of adverse effects was studied. An adverse drug reaction (ADR) causality was assessed by the WHO-UMC algorithm and preventability by Schumock and Thornton's criteria. Univariate and multivariate logistic regression analyses were used to identify the predictors related to chemotherapy-induced adverse effects. Results: The data concerned 188 patients, of which 64.3 % developed chemotherapy-related adverse effects. Among the prescribed anti-neoplastic drugs, a combination of 5-Fluorouracil, Cisplatin and Paclitaxel regimen was associated with the majority (91.42 %) of the adverse effects. Alopecia was the most common adverse effect noted in 26.44 % of patients, followed by nausea and anaemia in 15.7 % and 9.9 % of patients, respectively. Independent predictors of chemotherapy-related adverse effects were site (Adjusted odds ratio [AOR] = 1.95; 95 % CI 1.04 - 3.62, p = 0.03), chemotherapy and radiotherapy treatment (AOR = 5.00; 95 % CI 2.62 - 9.53, p < 0.001), combination regimen of 5-Fluorouracil, Cisplatin and Paclitaxel (AOR = 8.68; 95 % CI 2.55 - 29.48, p = 0.001), associated comorbidities (AOR = 16.68; 95 % CI 2.45 - 28.34, p < 0.001). Causality assessment revealed most adverse effects (82.64 %) to be possible. Conclusion: The adverse effect varies with the type of regimen which is prescribed for the patient. Site of cancer, concomitant radiotherapy treatment and associated comorbidities were the identifiable risk factors for developing adverse effects. Onco-pharmacovigilance studies in the future will help to provide tailored treatment to patients and improve their quality of life.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74320234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5937/scriptamed54-44028
Suryakanth Kalluraya, Shershah Kammar, A. Hosangadi, Akash Kumar
The reconstructive surgeon faces a problem when dealing with larger soft tissue lesions over the knee and the proximal two thirds of the tibia, two crucial sites of the lower limb. Large free flaps or pedicled local flaps are two solutions of the problem. The soleus or gastrocnemius flaps by itself are insufficient. Without using free flaps, combined gastrocnemius-soleus flaps can be employed effectively. Indicators for this kind of flap are still quite uncommon in children. In two clinical cases, authors will share their expertise and talk about the use of this kind of flap in the treatment of soft tissue abnormalities in children. Two cases were outlined: the use and outcome of the combination pedicled gastrocnemius-hemisoleus double muscle flap to repair significant defects around the knee and leg in children.
{"title":"Role of the double muscle gastrocnemius-soleus flap in soft tissue defect reconstruction of the leg in children: Case series","authors":"Suryakanth Kalluraya, Shershah Kammar, A. Hosangadi, Akash Kumar","doi":"10.5937/scriptamed54-44028","DOIUrl":"https://doi.org/10.5937/scriptamed54-44028","url":null,"abstract":"The reconstructive surgeon faces a problem when dealing with larger soft tissue lesions over the knee and the proximal two thirds of the tibia, two crucial sites of the lower limb. Large free flaps or pedicled local flaps are two solutions of the problem. The soleus or gastrocnemius flaps by itself are insufficient. Without using free flaps, combined gastrocnemius-soleus flaps can be employed effectively. Indicators for this kind of flap are still quite uncommon in children. In two clinical cases, authors will share their expertise and talk about the use of this kind of flap in the treatment of soft tissue abnormalities in children. Two cases were outlined: the use and outcome of the combination pedicled gastrocnemius-hemisoleus double muscle flap to repair significant defects around the knee and leg in children.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83374340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5937/scriptamed54-43882
S. Jovičić, Jagoda Balaban, Vesna Gajanin
Background/Aim: Pruritus is an unpleasant sensation that provokes the desire to scratch. It is one of the most common reasons why patients consult a dermatologist. Aim of this study was to determine the association of chronic pruritus with skin and systemic diseases, as well as the age and sex distribution in the studied population. Methods: The cross-sectional study included 120 patients of both sexes who, in the period from January 2017 to January 2021, received outpatient and inpatient treatment at the Skin and Venereal Diseases Clinic of the University Clinical Centre of the Republic of Srpska diagnosed with pruritus. Through the Clinical Information System insight was gained into the medical history and other documentation of the subjects from which data were taken on the age and sex of the subjects, onset, course and duration of pruritus, daily or seasonal variations in intensity, as well as the presence of associated skin and systemic diseases. Results: Out of a total of 120 subjects, a larger number (53.3 %) of subjects with chronic pruritus were male, and 46.7 % were female, the difference was statistically significant (p < 0.05). The analysis of the distribution of subjects according to their age revealed that the largest number of subjects (62.6 %) was over 65 years of age, while 38.4 % of subjects were under 65 years of age. The difference in the age structure was statistically significant (p < 0.05). In subjects older than 65 years pruritus was most frequently (47.3 %) associated with diabetes and in subjects under 65 years of age with skin diseases and conditions. The difference was statistically significant (p < 0.05). Conclusion: In people aged over 65 years, pruritus was most frequently associated with systemic diseases (diabetes mellitus) and in people aged under 65 years with dermatological diseases (Dermatitis atopica).
{"title":"Association of systemic diseases with chronic pruritus","authors":"S. Jovičić, Jagoda Balaban, Vesna Gajanin","doi":"10.5937/scriptamed54-43882","DOIUrl":"https://doi.org/10.5937/scriptamed54-43882","url":null,"abstract":"Background/Aim: Pruritus is an unpleasant sensation that provokes the desire to scratch. It is one of the most common reasons why patients consult a dermatologist. Aim of this study was to determine the association of chronic pruritus with skin and systemic diseases, as well as the age and sex distribution in the studied population. Methods: The cross-sectional study included 120 patients of both sexes who, in the period from January 2017 to January 2021, received outpatient and inpatient treatment at the Skin and Venereal Diseases Clinic of the University Clinical Centre of the Republic of Srpska diagnosed with pruritus. Through the Clinical Information System insight was gained into the medical history and other documentation of the subjects from which data were taken on the age and sex of the subjects, onset, course and duration of pruritus, daily or seasonal variations in intensity, as well as the presence of associated skin and systemic diseases. Results: Out of a total of 120 subjects, a larger number (53.3 %) of subjects with chronic pruritus were male, and 46.7 % were female, the difference was statistically significant (p < 0.05). The analysis of the distribution of subjects according to their age revealed that the largest number of subjects (62.6 %) was over 65 years of age, while 38.4 % of subjects were under 65 years of age. The difference in the age structure was statistically significant (p < 0.05). In subjects older than 65 years pruritus was most frequently (47.3 %) associated with diabetes and in subjects under 65 years of age with skin diseases and conditions. The difference was statistically significant (p < 0.05). Conclusion: In people aged over 65 years, pruritus was most frequently associated with systemic diseases (diabetes mellitus) and in people aged under 65 years with dermatological diseases (Dermatitis atopica).","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85278737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5937/scriptamed54-42288
Ram Singh, Adrián Isaza, G. Fatima, A. Maheshwari, N. Verma, Shashank Joshi, Richa Mishra, Poonam Tiwari, S. Joshi, Sudha Yeluri, Aminat Magamedova, Magomed Magamedov
High-quality Indo-Mediterranean foods are characterised with unrefined, unprocessed foods, whole grains such as dry millets and beans and porridge. Vegetables such as leaves and gourds, nuts and fruits such as apples, grapes, papaya, guava, etc are major components of this diet. It seems that healthy vegetable oils such as olive, mustard, rape seed oil and protein sources that are beneficial; beans, pulses, cottage cheese are crucial in this diet. Among animal sources, white meats; such as sea foods should also be part of this diet. Vegetables and spices with medicinal properties; gourds, turmeric, fenugreek, coriander and cumin may also be called high quality nutraceutical foods, respectively. There is a need to find out traditional foods from all other countries which may be protective and healthy. There is evidence that calories have tremendous role in weight gain and weight loss. It seems that emphasis on food quality is crucial for prevention of oxidative stress and inflammation in the adipocytes, which predispose obesity and risk of cardiovascular diseases (CVDs) and diabetes. There are gaps in knowledge about the qualities of traditional foods, which prompt authors to present this communication.
{"title":"The twelve fundamental dimensions of a high quality Indo-Mediterranean diet","authors":"Ram Singh, Adrián Isaza, G. Fatima, A. Maheshwari, N. Verma, Shashank Joshi, Richa Mishra, Poonam Tiwari, S. Joshi, Sudha Yeluri, Aminat Magamedova, Magomed Magamedov","doi":"10.5937/scriptamed54-42288","DOIUrl":"https://doi.org/10.5937/scriptamed54-42288","url":null,"abstract":"High-quality Indo-Mediterranean foods are characterised with unrefined, unprocessed foods, whole grains such as dry millets and beans and porridge. Vegetables such as leaves and gourds, nuts and fruits such as apples, grapes, papaya, guava, etc are major components of this diet. It seems that healthy vegetable oils such as olive, mustard, rape seed oil and protein sources that are beneficial; beans, pulses, cottage cheese are crucial in this diet. Among animal sources, white meats; such as sea foods should also be part of this diet. Vegetables and spices with medicinal properties; gourds, turmeric, fenugreek, coriander and cumin may also be called high quality nutraceutical foods, respectively. There is a need to find out traditional foods from all other countries which may be protective and healthy. There is evidence that calories have tremendous role in weight gain and weight loss. It seems that emphasis on food quality is crucial for prevention of oxidative stress and inflammation in the adipocytes, which predispose obesity and risk of cardiovascular diseases (CVDs) and diabetes. There are gaps in knowledge about the qualities of traditional foods, which prompt authors to present this communication.","PeriodicalId":33497,"journal":{"name":"Scripta Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91118123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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