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A Case of Spontaneous Cervical Hematoma caused by Parathyroid Adenoma 甲状旁腺瘤所致自发性宫颈血肿1例
Pub Date : 2021-11-30 DOI: 10.21593/kjhno/2021.37.2.101
Gyeong Hwa Jeon, Hyeon Seok Oh, H. Byeon
Spontaneous cervical hematomas could lead to life-threatening complications, and aneurysms, retopharyngeal abscesses, parathyroid adenomas, laryngeal cysts, and neurogenic tumors should be distinguished as possible underlying causes. Symptoms accompanying spontaneous cervical hematoma include cervical swelling, ecchymosis, dysphagia, dyspnea and hoarseness. We recently experienced a case of spontaneous cervical hematoma in a 52-year-old woman, who initially presented with cervical swelling after severe coughing two days ago. Resultingly parathyroid adenoma was finally confirmed after mass excision. Therefore, we present this unique case with a review of the literature.
自发性宫颈血肿可导致危及生命的并发症,动脉瘤、咽后脓肿、甲状旁腺瘤、喉囊肿和神经源性肿瘤应作为可能的潜在病因加以区分。自发性宫颈血肿的症状包括宫颈肿胀、瘀斑、吞咽困难、呼吸困难和声音嘶哑。我们最近经历了一个52岁女性自发性宫颈血肿的病例,她在两天前剧烈咳嗽后最初表现为宫颈肿胀。结果经肿块切除后确诊为甲状旁腺瘤。因此,我们提出这个独特的情况下,回顾文献。
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引用次数: 0
A Case of Myxoid Liposarcoma of Neck 颈部黏液样脂肪肉瘤1例
Pub Date : 2021-11-30 DOI: 10.21593/kjhno/2021.37.2.71
K. Lee, J. Kie, H. Shin, Ji-hoon Kim
Liposarcoma is a very rare malignant tumor affecting the head and neck area. Since it is an invasive and life-threatening disease, active treatments is necessary. However, differential it from lipoma, its corresponding benign counterpart, may be difficult. Herein, we report a rare case of posterior neck myxoid liposarcoma in a 72-year-old man who was initially misdiagnosed with lipoma, including a literature review of differential diagnosis between lipoma and liposarcoma.
脂肪肉瘤是一种非常罕见的影响头颈部的恶性肿瘤。由于它是一种侵袭性和危及生命的疾病,积极的治疗是必要的。然而,将其与相应的良性肿瘤脂肪瘤鉴别可能是困难的。在此,我们报告一名72岁男性后颈部黏液样脂肪肉瘤的罕见病例,他最初被误诊为脂肪瘤,包括对脂肪瘤和脂肪肉瘤鉴别诊断的文献回顾。
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引用次数: 0
What's New in Molecular Targeted Therapies for Head and Neck Cancer? 头颈癌分子靶向治疗有什么新进展?
Pub Date : 2021-11-30 DOI: 10.21593/kjhno/2021.37.2.11
Seoyoung Lee, H. Kim
Head and neck cancer is the 6th most frequently diagnosed solid tumor in the world. Alcohol consumption, smoking, and HPV infection are associated with the incidence of head and neck squamous cell carcinoma (HNSCC). Although a multidisciplinary approach is a key strategy for the treatment of locally advanced HNSCC, systemic therapy is the mainstream of recurrent or metastatic HNSCC treatment. Stage IV HNSCC has a relatively poor prognosis with median overall survival of around one year. There have been many clinical trials to investigate the efficacy of target agents in the treatment of HNSCC. In the HPV-negative HNSCC, TP53 and CDKN2A are the most commonly mutated genes. In the HPV-positive HNSCC, the PI3K pathway is frequently altered. EGFR, PI3K, cell cycle pathway, MET, HRAS, and IL6/JAK/STAT pathway are explored targets in HNSCC. In this study, we review the target pathways and agents under research. We also introduce here umbrella trials of recurrent or metastatic HNSCC conducted by the Korea Cancer Study Group. The combination of target agents with immune checkpoint inhibitors or cytotoxic chemotherapies would be a future step in the precision medicine of HNSCC treatment.
头颈癌是世界上第六大最常诊断的实体肿瘤。饮酒、吸烟和HPV感染与头颈部鳞状细胞癌(HNSCC)的发病率相关。虽然多学科方法是局部晚期HNSCC治疗的关键策略,但全身治疗是复发或转移性HNSCC治疗的主流。IV期HNSCC预后相对较差,中位总生存期约为1年。目前已有许多临床试验来研究靶向药物治疗恶性鳞状细胞癌的疗效。在hpv阴性HNSCC中,TP53和CDKN2A是最常见的突变基因。在hpv阳性的HNSCC中,PI3K通路经常发生改变。EGFR、PI3K、细胞周期通路、MET、HRAS和IL6/JAK/STAT通路是探索HNSCC的靶点。在本研究中,我们综述了正在研究的靶标途径和药物。我们也在此介绍由韩国癌症研究小组进行的复发或转移性HNSCC的总括性试验。靶向药物与免疫检查点抑制剂或细胞毒性化疗的联合将是HNSCC治疗精准医学的未来一步。
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引用次数: 0
A Case of Buccal Pilomatricoma Removed Through Intraoral Incision 经口内切口切除颊毛瘤1例
Pub Date : 2021-11-30 DOI: 10.21593/kjhno/2021.37.2.97
Hong-Dae Kim, M. Park, H. A. Lee, Y. Ji
Pilomatricoma(or calcifying epithelioma) is a not common benign solitary tumor originated from outer root sheath cell of hair follicle or hair follicle of sebaceous glands. The tumor usually presents as an asymptomatic, hard, superficial located, and skin colored to reddish blue cutaneous mass. Most of the tumors are less than 10mm in diameter and adherent to the skin. Recently, 48-year-old man presented with cheek mass. The tumor was 2.6cm sized and located at the subcutaneous layer of cheek on CT scan. The tumor was clearly removed via transoral approach with buccal incision leaving no wound on face. The mass was confirmed as pilomatricoma on pathologic examination. Herein, we report our experience with literature review.
毛瘤(又称钙化上皮瘤)是一种少见的良性孤立性肿瘤,起源于毛囊或皮脂腺毛囊的外根鞘细胞。肿瘤通常表现为无症状,坚硬,位于浅表,皮肤颜色至红蓝色皮肤肿块。大多数肿瘤直径小于10mm,附着于皮肤。最近,一名48岁男子出现面颊肿块。肿瘤大小为2.6cm, CT显示肿瘤位于面颊皮下。经口腔入路,颊部切口切除肿瘤,面部无伤口。病理检查证实肿块为毛瘤。在此,我们以文献回顾的方式报告我们的经验。
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引用次数: 0
What's New in Molecular Targeted Therapies for Thyroid Cancer? 甲状腺癌分子靶向治疗的新进展?
Pub Date : 2021-11-30 DOI: 10.21593/kjhno/2021.37.2.1
Seonwoo Min, Hyunseok Kang
Thyroid cancer refers to various cancers arising from thyroid gland. Differentiated thyroid cancers (DTCs) include papillary, follicular, and Hurthle cell carcinomas and represent cancers retain normal thyroid functions such as iodine uptake. Radioactive iodine (RAI) is generally used for upfront treatment of metastatic DTCs, but RAI refractory DTCs remain to be clinical challenges. Sorafenib and lenvatinib were approved for the treatment of RAI refractory DTCs and more recently, genomics-based targeted therapies have been developed for NTRK and RET gene fusion-positive DTCs. Poorly differentiated and anaplastic thyroid cancers (ATCs) are extremely challenging diseases with aggressive courses. BRAF/MEK inhibition has been proven to be highly effective in BRAF V600E mutation-positive ATCs and immune checkpoint inhibitors have shown promising activities. Medullary thyroid cancers, which arise from parafollicular cells of thyroid, represent a unique subset of thyroid cancer and mainly driven by RET mutation. In addition to vandetanib and cabozantinib, highly specific RET inhibitors such as selpercatinib and pralsetinib have demonstrated impressive activity and are in clinical use.
甲状腺癌是指由甲状腺引起的各种癌症。分化型甲状腺癌(dtc)包括乳头状、滤泡和Hurthle细胞癌,代表了保留正常甲状腺功能(如碘摄取)的癌症。放射性碘(RAI)通常用于转移性dtc的前期治疗,但RAI难治性dtc仍然是临床挑战。Sorafenib和lenvatinib被批准用于治疗RAI难治性dtc,最近,基于基因组学的靶向治疗已经开发用于NTRK和RET基因融合阳性的dtc。低分化和间变性甲状腺癌(ATCs)是极具挑战性的疾病,具有侵袭性病程。BRAF/MEK抑制已被证明在BRAF V600E突变阳性的ATCs中非常有效,免疫检查点抑制剂已显示出有希望的活性。甲状腺髓样癌起源于甲状腺滤泡旁细胞,是甲状腺癌的一个独特亚型,主要由RET突变驱动。除vandetanib和cabozantinib外,高度特异性的RET抑制剂如selpercatinib和pralsetinib已显示出令人印象深刻的活性并已在临床使用。
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引用次数: 0
Lipoma of the Floor of the Mouth: a Case Report 口腔底脂肪瘤1例报告
Pub Date : 2019-05-30 DOI: 10.21593/KJHNO/2019.35.1.29
Dong Hyun Kim, S. Han, Jae Hoon Lee
Lipoma is one of the most common benign tumors in the human body. However, they are uncommon in the oral cavity. Oral lipomas can occur on the cheeks, tongue, lips, gums and rarely on the floor of the mouth. Clinical symptoms are usually asymptomatic yellow masses. Sometimes the tumor grows and can have difficulty speaking and mastication. The treatment of lipoma is surgical excision, and recurrence is rare. We present a case of oral lipoma in an unusal location on the floor of mouth which is rare in the literature.
脂肪瘤是人体最常见的良性肿瘤之一。然而,它们在口腔中并不常见。口腔脂肪瘤可发生在面颊、舌头、嘴唇、牙龈,很少发生在口腔底部。临床症状通常为无症状的黄色肿块。有时肿瘤会生长,并可能导致说话和咀嚼困难。脂肪瘤的治疗是手术切除,复发是罕见的。我们提出一个病例的口腔脂肪瘤在一个不寻常的位置,在口腔底部,这是罕见的文献。
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引用次数: 0
A Case of Intraductal Papilloma arising in the Parotid Gland 腮腺导管内乳头状瘤1例
Pub Date : 2019-05-30 DOI: 10.21593/KJHNO/2019.35.1.41
Soojin Kim, So Jeong Lee, H. Kim, S. Jung
Intraductal papilloma is an extremely rare benign tumor especially when it arises from major salivary gland. Recently, we experienced a case of an intraductal papilloma arising from the parotid gland in a 51-year-old woman. The radiologic finding showed lobulated enhancing and cystic solid mass in the left parotid superficial lobe. Superficial parotidectomy was performed. Pathological findings showed papillary proliferations with fibrovascular cores lined with bland cuboidal or columnar epithelial cells, and immunohistochemical stain results were consistent with intraductal papilloma. We report a case of intraductal papilloma in parotid gland with a review of literature.
摘要导管内乳头状瘤是一种极为罕见的良性肿瘤,尤其发生于大涎腺。最近,我们经历了一个病例导管内乳头状瘤起源于腮腺在51岁的妇女。影像学表现为左侧腮腺浅叶分叶强化及囊性实性肿块。行腮腺浅表切除术。病理结果显示乳头状增生,纤维血管核心排列着淡色的立方或柱状上皮细胞,免疫组织化学染色结果与导管内乳头状瘤一致。我们报告一例腮腺导管内乳头状瘤并复习文献。
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引用次数: 0
Use of Acellular Allogenic Dermal Matrix in Soft Palate Reconstruction after Excision the Pleomorphic Adenoma 脱细胞异体真皮基质在多形性腺瘤切除后软腭重建中的应用
Pub Date : 2019-05-30 DOI: 10.21593/KJHNO/2019.35.1.21
Jae Seong Lee, G. C. Lim, Jeong Hong Kim, Jae Kyoung Kang, M. Shin, B. Yun
Recent studies have reported on the reconstruction of oral mucosal defects using acellular dermal matrix (ADM). This case report describes the reconstruction of a soft-palate mucosal defect using ADM. A 43-year-old man developed a 2.5 cm × 3 cm soft-palate mucosal defect after the removal of a lump on the soft palate andreconstructed the defect using ADM without further complications. Reconstruction of the soft palate with ADM could be more convenient than traditional methods including primary closure, skin graft, and local or free flap without complications.
近年来有研究报道用脱细胞真皮基质(ADM)重建口腔黏膜缺损。本病例报告描述了使用ADM重建软腭粘膜缺损。一名43岁男性在软腭肿块切除后,使用ADM重建了2.5 cm × 3 cm的软腭粘膜缺损,没有进一步的并发症。ADM重建软腭比传统方法(一期闭合、植皮、局部或游离皮瓣)更方便,且无并发症。
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引用次数: 0
A case of neck lipoblastoma in a pediatric patient 小儿颈部脂肪母细胞瘤1例
Pub Date : 2019-05-30 DOI: 10.21593/KJHNO/2019.35.1.25
Jae Hyung Kim, L. H. Choi, Young-Chan Kim, S. Baek
Lipoblastoma is a rare benign tumor with 80-90% occurring in children less than 3 years of age and 40% occurring in children less than 1 year of age. The most common site of incidence is limb, and then trunk. Neck is the rare site of incidence. The main symptom that the patient complains about is a rapidly growing neck mass without pain. When the size of mass increases, it can cause dyspnea, Horner's syndrome. Lipoblastoma is usually diagnosed as a lipoma in the fine needle aspiration. Since it is not differentiated from lipoma, liposarcoma, and hibernating adenoma in CT and MRI, the definitive diagnosis is histologic diagnosis through surgical resection. The treatment is complete surgical resection. And recurrence rate is 9-25% due to incomplete resection. Authors report this case with a review of literatures since we experienced a case of lipoblastoma diagnosed histopathologically after surgical treatment of neck mass.
脂肪母细胞瘤是一种罕见的良性肿瘤,80-90%发生在3岁以下儿童中,40%发生在1岁以下儿童中。最常见的发病部位是肢体,其次是躯干。颈部是罕见的发病部位。患者主诉的主要症状是颈部肿块迅速增大而无疼痛感。当肿块增大时,可引起呼吸困难,即霍纳综合征。脂肪母细胞瘤通常在细针穿刺中被诊断为脂肪瘤。由于CT和MRI不能与脂肪瘤、脂肪肉瘤、冬眠性腺瘤鉴别,因此最终的诊断是通过手术切除的组织学诊断。治疗方法是完全手术切除。复发率为9-25%。作者报告此病例,并回顾文献,因为我们经历了一个病例的脂肪母细胞瘤的病理诊断后手术治疗颈部肿块。
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引用次数: 1
A Case report of MALT lymphoma in parotid gland 腮腺MALT淋巴瘤1例
Pub Date : 2019-05-30 DOI: 10.21593/KJHNO/2019.35.1.33
M. Kim, J. Choi, Hong Geun Ahn, Joong Su Park, Y. Kim
Mucosa-associated lymphoid tissue (MALT) lymphoma has specific clinical and pathologic features. The most common site MALT lymphomas is the stomach; however, it can also occur in other organs, such as the salivary glands. MALT lymphoma is rare, but its prognosis is good. A 32-year-old man visited Konyang university hospital with parotid mass. Superficial partial parotidectomy was performed to exclude lymphoid neoplasms. IgH gene rearrangement analysis of the surgical specimen led to the diagnosis of MALT lymphoma. The patient underwent esophagogastroduodenoscopy, positron emission tomography-computed tomography, and whole-body bone scan. Regional or distant metastasis was not observed on staging workup. The patient underwent postoperative radiation therapy, there has been no recurrence of MALT lymphoma to date. Here, we report this rare case of parotid MALT lymphoma that was treated with surgery and postoperative radiation therapy.
粘膜相关淋巴组织(MALT)淋巴瘤具有特殊的临床和病理特征。MALT淋巴瘤最常见的部位是胃;然而,它也可能发生在其他器官,如唾液腺。MALT淋巴瘤罕见,但预后良好。一名32岁男子因腮腺肿块到建阳大学医院就诊。行腮腺部分浅表切除术以排除淋巴样肿瘤。手术标本的IgH基因重排分析导致MALT淋巴瘤的诊断。患者接受了食管胃十二指肠镜检查、正电子发射断层扫描、计算机断层扫描和全身骨扫描。分期检查未见局部或远处转移。患者术后接受放疗,至今未见MALT淋巴瘤复发。在此,我们报告一例罕见的腮腺MALT淋巴瘤,接受手术和术后放射治疗。
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引用次数: 1
期刊
Korean Society for Head and Neck Oncology
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