Pub Date : 2023-10-25DOI: 10.33719/yud.2023-18-3-1345876
Emre ŞAM, Mithat EKŞİ, Fatih AKKAŞ, Halil BAYTEKİN, Eray Metin GÜLER, Abdülmüttalip ŞİMŞEK, Feyzi Arda ATAR, Abdurrahim KOÇYİĞİT, Ali İhsan TAŞÇI
Objective: Recent research has centered on the role of oxidative stress and free oxygen radicals in the formation of stones. Viburnum opulus L. (VO) is a fruit species known for its antioxidant activity, and its juice preparation is used in Turkish traditional medicine for stone removal. This study aimed to investigate the effects of VO on calcium oxalate (CaOx) crystallization and oxidative stress in rats with ethylene glycol (EG)-induced nephrolithiasis. Material and Methods: Fifty adult male Wistar Hannover rats were divided into five groups: control (Group 1), EG (Group 2), EG + 50 mg/kg VO (Group 3), EG + 100 mg/kg VO (Group 4), and EG + 200 mg/kg VO (Group 5). On days 7, 14, and 28, 24-hour urine was collected, and blood samples were taken. On day 28, the rats were sacrificed, and inflammation, oxidative stress, and CaOx crystallization in kidney tissue were evaluated under polarized light microscopy. Results: A statistically significant difference was found between Group 1 and Group 2 in terms of serum inflammation parameters, acute kidney injury, and oxidative stress evaluated on days 7, 14, and 28, and tissue inflammation and oxidative stress parameters evaluated on day 28. It was observed that these parameters improved in Groups 3-5 compared to Group 2, and the level of statistical significance increased as the dose increased. In the histopathological evaluation of the tissues on day 28, the mean number of crystals was statistically significantly higher in Group 2 than in Group 1. These parameters improved in Groups 3-5 compared to Group 2, and there was a statistically significant difference when Groups 4 and 5 were compared to Group 2. Conclusion: It was found that VO improved inflammation, oxidative stress, acute kidney injury, and CaOx crystallization in rats with EG-induced nephrolithiasis in direct proportion to the increase in dose.
{"title":"The Effects of Viburnum Opulus L. on Kidneys of Rats with Ethylene Glycol-induced Nephrolithiasis","authors":"Emre ŞAM, Mithat EKŞİ, Fatih AKKAŞ, Halil BAYTEKİN, Eray Metin GÜLER, Abdülmüttalip ŞİMŞEK, Feyzi Arda ATAR, Abdurrahim KOÇYİĞİT, Ali İhsan TAŞÇI","doi":"10.33719/yud.2023-18-3-1345876","DOIUrl":"https://doi.org/10.33719/yud.2023-18-3-1345876","url":null,"abstract":"Objective: Recent research has centered on the role of oxidative stress and free oxygen radicals in the formation of stones. Viburnum opulus L. (VO) is a fruit species known for its antioxidant activity, and its juice preparation is used in Turkish traditional medicine for stone removal. This study aimed to investigate the effects of VO on calcium oxalate (CaOx) crystallization and oxidative stress in rats with ethylene glycol (EG)-induced nephrolithiasis. Material and Methods: Fifty adult male Wistar Hannover rats were divided into five groups: control (Group 1), EG (Group 2), EG + 50 mg/kg VO (Group 3), EG + 100 mg/kg VO (Group 4), and EG + 200 mg/kg VO (Group 5). On days 7, 14, and 28, 24-hour urine was collected, and blood samples were taken. On day 28, the rats were sacrificed, and inflammation, oxidative stress, and CaOx crystallization in kidney tissue were evaluated under polarized light microscopy. Results: A statistically significant difference was found between Group 1 and Group 2 in terms of serum inflammation parameters, acute kidney injury, and oxidative stress evaluated on days 7, 14, and 28, and tissue inflammation and oxidative stress parameters evaluated on day 28. It was observed that these parameters improved in Groups 3-5 compared to Group 2, and the level of statistical significance increased as the dose increased. In the histopathological evaluation of the tissues on day 28, the mean number of crystals was statistically significantly higher in Group 2 than in Group 1. These parameters improved in Groups 3-5 compared to Group 2, and there was a statistically significant difference when Groups 4 and 5 were compared to Group 2. Conclusion: It was found that VO improved inflammation, oxidative stress, acute kidney injury, and CaOx crystallization in rats with EG-induced nephrolithiasis in direct proportion to the increase in dose.","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"19 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.33719/yud.2023-18-3-1328451
Bahadır ERMEÇ, Mehmet Gökhan ÇULHA
Objective: The clean intermittent catheterization is a device used by individuals with neurogenic bladder. The ISC can be used by the patient or by a caregiver. The aim of this study is to examine the relationship between ISC practice skills and quality of life of individuals using ISC. Material and Methods: Between June 2018 and May 2019,126 patients using Clean Intermittent Self Catheterization (ISC) in a city hospital urology clinic was included in the study. All patients completed the Turkish version of the ISC-Q(T-ISC-Q) and Qualiveen questionnaires. ISC users were divided into two groups: Self-administered and caregiver practitioners. Spearman’s correlation coefficients between ISC-Q and Qualiveen were used. Results: The mean age of the patients was 51.53±16.47 years, and the duration of ISC was 42.15 ± 12.56 months. A total of 72 patients reported that they performed the ISC, while the number of patients who underwent ISC by the caregiver was 54. ISC-Q scores were 70.98±15.41 for ease of use, 42.85±18.40 for convenience, 75.71±14.97 for privacy, and 56.34±14.57 for psychological well-being, respectively. The results of the Cronbach α was 0.782. ISC-Q total score was positively correlated with Qualiveen total score (r=0.567, p=0.04). Patients who used their own ISC had higher ISC-Q scores than patients who had ISC administered by the caregiver. Conclusion: As a result, while the ease of use of ISC is high, there is a decrease in the convenience and psychological well-being of the patients using ISC. This was lower in patients who had ISC administered by the caregiver.
{"title":"Evaluation of the Quality of Life of Patients Who Use Intermittant SelfCatheterization by Themselves and by Their Caregivers","authors":"Bahadır ERMEÇ, Mehmet Gökhan ÇULHA","doi":"10.33719/yud.2023-18-3-1328451","DOIUrl":"https://doi.org/10.33719/yud.2023-18-3-1328451","url":null,"abstract":"Objective: The clean intermittent catheterization is a device used by individuals with neurogenic bladder. The ISC can be used by the patient or by a caregiver. The aim of this study is to examine the relationship between ISC practice skills and quality of life of individuals using ISC. Material and Methods: Between June 2018 and May 2019,126 patients using Clean Intermittent Self Catheterization (ISC) in a city hospital urology clinic was included in the study. All patients completed the Turkish version of the ISC-Q(T-ISC-Q) and Qualiveen questionnaires. ISC users were divided into two groups: Self-administered and caregiver practitioners. Spearman’s correlation coefficients between ISC-Q and Qualiveen were used. Results: The mean age of the patients was 51.53±16.47 years, and the duration of ISC was 42.15 ± 12.56 months. A total of 72 patients reported that they performed the ISC, while the number of patients who underwent ISC by the caregiver was 54. ISC-Q scores were 70.98±15.41 for ease of use, 42.85±18.40 for convenience, 75.71±14.97 for privacy, and 56.34±14.57 for psychological well-being, respectively. The results of the Cronbach α was 0.782. ISC-Q total score was positively correlated with Qualiveen total score (r=0.567, p=0.04). Patients who used their own ISC had higher ISC-Q scores than patients who had ISC administered by the caregiver. Conclusion: As a result, while the ease of use of ISC is high, there is a decrease in the convenience and psychological well-being of the patients using ISC. This was lower in patients who had ISC administered by the caregiver.","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"17 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.33719/yud.2023-18-3-1333185
Dilek BULUT, Çağrı COŞKUN, Uğur AYDIN
Objective: To analyze the parameters that can facilitate the differential diagnosis of brucella epididymorchitis (BEO) and non-brucella epididymorchitis (NBEO) and to facilitate early diagnosis. Material And Methods: The data of 23 BEO patients and 80 NBEO patients, who applied in a tertiary center in eastern Turkey, where brucellosis is common, were retrospectively analyzed. Age, hemogram parameters (white blood cell (WBC)), neutrophil, lymphocyte, monocyte, eosinophil, basophil, platelet, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), red blood cell distribution width (RDW), biochemical parameters (aspartate transaminase and alanine aminotransferase), inflammatory markers (C-reactive protein, erythrocyte sedimentation rate, and procalcitonin), urine culture, and scrotal doppler ultrasound findings were analyzed retrospectively and were compared between BEO and NBEO groups. Results: In the comparison of the BEO and NBEO groups, there was a significant difference between the two groups in WBC count, neutrophil count, monocytes count, NLR, MLR, MPV, and procalcitonin levels (p = 0.035, p = 0.007, p = 0.003, p = 0.005, p = 0.01, p < 0.001, p < 0.001, respectively). Conclusions: The NLR may be promising for use in the early diagnosis of BEO. The MPV also drew attention as parameters that can be evaluated
目的:探讨布鲁氏菌性附睾支气管炎(BEO)与非布鲁氏菌性附睾支气管炎(NBEO)的鉴别诊断参数，促进早期诊断。材料与方法:回顾性分析土耳其东部布鲁氏菌病高发地区某三级中心23例BEO患者和80例NBEO患者的资料。年龄、血象参数(白细胞(WBC)、中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞、嗜碱性粒细胞、血小板、中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)、血小板与淋巴细胞比值(PLR)、平均血小板体积(MPV)、红细胞分布宽度(RDW)、生化参数(天冬氨酸转氨酶和丙氨酸转氨酶)、炎症标志物(c反应蛋白、红细胞沉降率、降钙素原)、尿液培养、回顾性分析BEO组和NBEO组的阴囊多普勒超声表现。结果:BEO组与NBEO组比较，两组患者白细胞计数、中性粒细胞计数、单核细胞计数、NLR、MLR、MPV、降钙素原水平差异均有统计学意义(p = 0.035, p = 0.007, p = 0.003, p = 0.005, p = 0.01, p <0.001, p <分别为0.001)。结论:NLR在BEO的早期诊断中有较好的应用前景。MPV作为可评价的参数也备受关注
{"title":"Assessment of Hematological Parameters in the Diagnosis Brucella Epididymorchitis: Comparison of Brucella Epididymorchitis and Non-Brucella Epididymorchitis","authors":"Dilek BULUT, Çağrı COŞKUN, Uğur AYDIN","doi":"10.33719/yud.2023-18-3-1333185","DOIUrl":"https://doi.org/10.33719/yud.2023-18-3-1333185","url":null,"abstract":"Objective: To analyze the parameters that can facilitate the differential diagnosis of brucella epididymorchitis (BEO) and non-brucella epididymorchitis (NBEO) and to facilitate early diagnosis. Material And Methods: The data of 23 BEO patients and 80 NBEO patients, who applied in a tertiary center in eastern Turkey, where brucellosis is common, were retrospectively analyzed. Age, hemogram parameters (white blood cell (WBC)), neutrophil, lymphocyte, monocyte, eosinophil, basophil, platelet, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), red blood cell distribution width (RDW), biochemical parameters (aspartate transaminase and alanine aminotransferase), inflammatory markers (C-reactive protein, erythrocyte sedimentation rate, and procalcitonin), urine culture, and scrotal doppler ultrasound findings were analyzed retrospectively and were compared between BEO and NBEO groups. Results: In the comparison of the BEO and NBEO groups, there was a significant difference between the two groups in WBC count, neutrophil count, monocytes count, NLR, MLR, MPV, and procalcitonin levels (p = 0.035, p = 0.007, p = 0.003, p = 0.005, p = 0.01, p < 0.001, p < 0.001, respectively). Conclusions: The NLR may be promising for use in the early diagnosis of BEO. The MPV also drew attention as parameters that can be evaluated","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"96 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.33719/yud.2023-18-3-1293426
Mehmet Hamza GÜLTEKİN, Ufuk ÇAĞLAR, Abdullah ESMERAY, Akif ERBİN, Fatih YANARAL, Murat BAYKAL, Faruk ÖZGÖR, Ömer SARİLAR, Mehmet Fatih AKBULUT
Objective: Some systemic inflammatory response-based biomarkers are promising for predicting prognosis of non-muscle-invasive bladder cancer (NMIBC) patients and can contribute to the risk classification without any significant cost. We aimed to evaluate the neutrophil-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) for the prediction of recurrence and progression risk in patients with NMIBC. Material and Methods: The study included a retrospective analysis of 211 patients who underwent transurethral resection of bladder (TURB) in a tertiary referral center between 2015 and 2019. The receiver operating characteristic (ROC) curve was used to determine the cut-off value. The Kaplan-Meier curves and the log-rank test were constructed to evaluate the recurrence-free and progression-free survival rates according to different levels of inflammatory markers. The multivariate regression analysis was undertaken to estimate the independent prognostic factors. Results: The optimal cut-off value of SII was found to be 568 in the ROC analysis. According to the multivariate analysis, the SII value, number of tumors at the time of initial TURB, and European Organization for Research and Treatment of Cancer (EORTC) recurrence classification were statistically significant parameters in predicting recurrence. While tumor size, NLR, and SII achieved statistically significant levels in the univariate analysis, they didn’t have significance in the multivariate analysis. Conclusion: The SII, number of tumors, and EORTC recurrence classification are prognostic parameters that can be used in the assessment of recurrence. However, inflammatory parameters do not have the same predictive ability in the prediction of the progression rate.
{"title":"Relationship of Systemic Immune-Inflammation Index and Neutrophil-Lymphocyte ratio with Disease Recurrence and Progression risk in Non-Muscle-Invasive Bladder Cancer","authors":"Mehmet Hamza GÜLTEKİN, Ufuk ÇAĞLAR, Abdullah ESMERAY, Akif ERBİN, Fatih YANARAL, Murat BAYKAL, Faruk ÖZGÖR, Ömer SARİLAR, Mehmet Fatih AKBULUT","doi":"10.33719/yud.2023-18-3-1293426","DOIUrl":"https://doi.org/10.33719/yud.2023-18-3-1293426","url":null,"abstract":"Objective: Some systemic inflammatory response-based biomarkers are promising for predicting prognosis of non-muscle-invasive bladder cancer (NMIBC) patients and can contribute to the risk classification without any significant cost. We aimed to evaluate the neutrophil-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) for the prediction of recurrence and progression risk in patients with NMIBC. Material and Methods: The study included a retrospective analysis of 211 patients who underwent transurethral resection of bladder (TURB) in a tertiary referral center between 2015 and 2019. The receiver operating characteristic (ROC) curve was used to determine the cut-off value. The Kaplan-Meier curves and the log-rank test were constructed to evaluate the recurrence-free and progression-free survival rates according to different levels of inflammatory markers. The multivariate regression analysis was undertaken to estimate the independent prognostic factors. Results: The optimal cut-off value of SII was found to be 568 in the ROC analysis. According to the multivariate analysis, the SII value, number of tumors at the time of initial TURB, and European Organization for Research and Treatment of Cancer (EORTC) recurrence classification were statistically significant parameters in predicting recurrence. While tumor size, NLR, and SII achieved statistically significant levels in the univariate analysis, they didn’t have significance in the multivariate analysis. Conclusion: The SII, number of tumors, and EORTC recurrence classification are prognostic parameters that can be used in the assessment of recurrence. However, inflammatory parameters do not have the same predictive ability in the prediction of the progression rate.","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.33719/yud.2023-18-3-1306328
Ümit YILDIRIM, Mehmet EZER, Mehmet USLU, Bumin ÖRS, Fatih GOKALP
Objective: To assess the efficacy and safety of thulium laser vapoenucleation of the prostate and its impact on patient’s lower urinary tract symptoms, erectile, and ejaculatory functions, we conducted the current prospective trial employing a high-power (200 W) Thulium: YAG laser system. Material and Methods: Between December 2021 and June 2022, we prospectively collected data on patients who underwent Thulium vapoenucleation of the prostate (ThuVEP) in our clinic to treat the signs and symptoms of benign prostatic hyperplasia. A sample size of 50 cases was obtained after applying exclusion criteria. In the first and sixth months following surgery, all patients were compared to their preoperative status in terms of lower urinary tract symptoms, erectile function, and ejaculatory symptoms. The Modified Clavien-Dindo Classification was also used to classify the complications that occurred. Results: The patients' IPSS scores showed a notable and significant improvement at the end of the 6-month follow-up. When compared to the preoperative state, erectile functions as measured by the IIEF-5 score did not significantly change with the surgery. At the end of the follow-up period, there was a substantial deterioration of ejaculatory functions as measured by the MSHQ-EjD score. During and after the procedure, complications at the Clavien 3a level were seen in 2 (4%) of the patients, but no complications above this level were seen. Conclusion: The ThuVEP method, used in the surgical management of symptomatic benign prostatic hyperplasia, is safe and effective in terms of functional outcomes despite high-power (200 W) vapoenucleation. In this field, further randomized controlled studies with extended follow-up are required.
{"title":"How Is High Power (200w) Thulium Laser Vapoenucleation of the Prostate Impacting Functional Parameters? Short-Term Follow-Up Results","authors":"Ümit YILDIRIM, Mehmet EZER, Mehmet USLU, Bumin ÖRS, Fatih GOKALP","doi":"10.33719/yud.2023-18-3-1306328","DOIUrl":"https://doi.org/10.33719/yud.2023-18-3-1306328","url":null,"abstract":"Objective: To assess the efficacy and safety of thulium laser vapoenucleation of the prostate and its impact on patient’s lower urinary tract symptoms, erectile, and ejaculatory functions, we conducted the current prospective trial employing a high-power (200 W) Thulium: YAG laser system. Material and Methods: Between December 2021 and June 2022, we prospectively collected data on patients who underwent Thulium vapoenucleation of the prostate (ThuVEP) in our clinic to treat the signs and symptoms of benign prostatic hyperplasia. A sample size of 50 cases was obtained after applying exclusion criteria. In the first and sixth months following surgery, all patients were compared to their preoperative status in terms of lower urinary tract symptoms, erectile function, and ejaculatory symptoms. The Modified Clavien-Dindo Classification was also used to classify the complications that occurred. Results: The patients' IPSS scores showed a notable and significant improvement at the end of the 6-month follow-up. When compared to the preoperative state, erectile functions as measured by the IIEF-5 score did not significantly change with the surgery. At the end of the follow-up period, there was a substantial deterioration of ejaculatory functions as measured by the MSHQ-EjD score. During and after the procedure, complications at the Clavien 3a level were seen in 2 (4%) of the patients, but no complications above this level were seen. Conclusion: The ThuVEP method, used in the surgical management of symptomatic benign prostatic hyperplasia, is safe and effective in terms of functional outcomes despite high-power (200 W) vapoenucleation. In this field, further randomized controlled studies with extended follow-up are required.","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.33719/yud.2023-18-3-1341287
Ayberk İPLİKÇİ, Ahmet KELEŞ, Ümit Furkan SOMUN, Fatma YILMAZER, Gözde KIR, Asıf YILDIRIM
Kaposi sarcoma (KS) is a multifocal hemorrhagic sarcoma that occurs mainly in the extremities. KS limited to the penis is rare and usually associated with acquired immunodeficiency syndrome (AIDS). The clinical presentations and courses of KS in the penis demonstrate variability, with limited reports of non-HIV-related primary KS. Herein, we present the case of a 27-year-old male patient with a classic form of KS who had a primary glans penile macular lesion. In more detailed evaluations, we found no evidence of immunosuppression or systemic involvement of the disease. There was no recurrence in the patient who underwent surgical excision, and he was followed up.
{"title":"An Unusual Presentation of Penile Kaposi’s Sarcoma in an HIV-Negative Patient with a Circumcised Penis","authors":"Ayberk İPLİKÇİ, Ahmet KELEŞ, Ümit Furkan SOMUN, Fatma YILMAZER, Gözde KIR, Asıf YILDIRIM","doi":"10.33719/yud.2023-18-3-1341287","DOIUrl":"https://doi.org/10.33719/yud.2023-18-3-1341287","url":null,"abstract":"Kaposi sarcoma (KS) is a multifocal hemorrhagic sarcoma that occurs mainly in the extremities. KS limited to the penis is rare and usually associated with acquired immunodeficiency syndrome (AIDS). The clinical presentations and courses of KS in the penis demonstrate variability, with limited reports of non-HIV-related primary KS. Herein, we present the case of a 27-year-old male patient with a classic form of KS who had a primary glans penile macular lesion. In more detailed evaluations, we found no evidence of immunosuppression or systemic involvement of the disease. There was no recurrence in the patient who underwent surgical excision, and he was followed up.","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.33719/yud.2023;18-3-1269349
Mehtap KAVURMACI
Hemodialysis remains the most widely used method for treating renal failure. Life expectancy and quality in hemodialysis are directly proportional to the quality of dialysis, and this quality depends on the reliability and integrity of the patient’s vascular access route. The ideal vascular access route provides reliable, uncomplicated access to dialysis and is also suitable for the patient’s needs. Hemodialysis vascular access options have not changed substantially over the past six decades, and arteriovenous fistula (AVF) remains the access of choice. Although AVF is a vascular intervention recommended and preferred in clinical practice guidelines for hemodialysis, it can develop into serious complications such as thrombosis, hematoma, edema, peripheral ischemia, bleeding, and infection. To prevent these complications, it is extremely important to educate patients about AVF care. This review has been prepared as a guide for healthcare professionals who care for hemodialysis patients.
{"title":"Hemodialysis Vascular Access and Care","authors":"Mehtap KAVURMACI","doi":"10.33719/yud.2023;18-3-1269349","DOIUrl":"https://doi.org/10.33719/yud.2023;18-3-1269349","url":null,"abstract":"Hemodialysis remains the most widely used method for treating renal failure. Life expectancy and quality in hemodialysis are directly proportional to the quality of dialysis, and this quality depends on the reliability and integrity of the patient’s vascular access route. The ideal vascular access route provides reliable, uncomplicated access to dialysis and is also suitable for the patient’s needs. Hemodialysis vascular access options have not changed substantially over the past six decades, and arteriovenous fistula (AVF) remains the access of choice. Although AVF is a vascular intervention recommended and preferred in clinical practice guidelines for hemodialysis, it can develop into serious complications such as thrombosis, hematoma, edema, peripheral ischemia, bleeding, and infection. To prevent these complications, it is extremely important to educate patients about AVF care. This review has been prepared as a guide for healthcare professionals who care for hemodialysis patients.","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"9 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.33719/yud.2023-18-3-1355748
Arif ÖZKAN, Nusret ÇİLESİZ, Arif KALKANLI, Cem Tuğrul GEZMİŞ, Memduh AYDIN
Objective: The aim of this study is to investigate the relationship between R.E.N.A.L. nephrometry score (RNS), Padua score (PS), Centrality (C)-index and tumour aggressivity in T1 renal tumours and to question whether these scoring systems would provide information about the pathology of renal tumours to manage clinical judgement rather than the anatomy of tumour. Material and Methods: We evaluated 83 patients with stage 1 (T1N0M0) clear cell renal cell carcinoma (cRCC) according to preoperative radiological and pathological staging. Patients were divided according to pathological results of cRCC into two groups: Patients with Fuhrman grade 1 or 2 (FG1-2) (Non-aggresive group (NAG)) and patients with FG3-4 and/or TNM Stage 3 (Aggressive group (AG)). RNS, PS and C-index scores were calculated for each patient. Finally,the relationship between nephrometry scores and pathological aggressivity were compared. Results: The mean RNS was calculated as 7.3±2.4. Total RNS was significantly higher in AG (9.2±1.2) than in NAG (6±2.2) (p<0.001). RNS was an independent predictor of pathological aggressive disease (p<0.001). The cut off value of RNS at the highest area under curve was 8 (p<0.001). The mean PS was calculated as 8.1±1.6. PS was also an independent predictor of pathological aggressive disease (p<0.001). The cut off value of PS at the highest area under curve was 8 (p<0.001). The mean C-index score of AG (1.4 ± 0.4) was significantly lower (p<0.001) than NAG (2.7±2.0). C-index is significant in predicting pathological aggressiveness (p<0.001). Conclusions: Our results suggested that higher RNS and PS scores, lower C-index scores were associated with tumour aggressivity of renal tumours.
{"title":"Could Renal Tumour Scoring Systems Predict Tumour Aggressivity?","authors":"Arif ÖZKAN, Nusret ÇİLESİZ, Arif KALKANLI, Cem Tuğrul GEZMİŞ, Memduh AYDIN","doi":"10.33719/yud.2023-18-3-1355748","DOIUrl":"https://doi.org/10.33719/yud.2023-18-3-1355748","url":null,"abstract":"Objective: The aim of this study is to investigate the relationship between R.E.N.A.L. nephrometry score (RNS), Padua score (PS), Centrality (C)-index and tumour aggressivity in T1 renal tumours and to question whether these scoring systems would provide information about the pathology of renal tumours to manage clinical judgement rather than the anatomy of tumour. Material and Methods: We evaluated 83 patients with stage 1 (T1N0M0) clear cell renal cell carcinoma (cRCC) according to preoperative radiological and pathological staging. Patients were divided according to pathological results of cRCC into two groups: Patients with Fuhrman grade 1 or 2 (FG1-2) (Non-aggresive group (NAG)) and patients with FG3-4 and/or TNM Stage 3 (Aggressive group (AG)). RNS, PS and C-index scores were calculated for each patient. Finally,the relationship between nephrometry scores and pathological aggressivity were compared. Results: The mean RNS was calculated as 7.3±2.4. Total RNS was significantly higher in AG (9.2±1.2) than in NAG (6±2.2) (p<0.001). RNS was an independent predictor of pathological aggressive disease (p<0.001). The cut off value of RNS at the highest area under curve was 8 (p<0.001). The mean PS was calculated as 8.1±1.6. PS was also an independent predictor of pathological aggressive disease (p<0.001). The cut off value of PS at the highest area under curve was 8 (p<0.001). The mean C-index score of AG (1.4 ± 0.4) was significantly lower (p<0.001) than NAG (2.7±2.0). C-index is significant in predicting pathological aggressiveness (p<0.001). Conclusions: Our results suggested that higher RNS and PS scores, lower C-index scores were associated with tumour aggressivity of renal tumours.","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.33719/yud.2023-18-3-1350497
Nalan SAYGI EMİR, Fatma ÇITAK KARACAER
Objective: To investigated whether low and high MAC (Minimum Aleveolar Concentration) level of anesthesia have an effect on the depth of anesthesia, clinical results paremeters in patients underwent radical cystectomy in accordance with ERAS (Enhanced Recovery After Surgery) protocols Material and Methods: Retrospective data of 41 patients underwent radical cystectomy between 2019-2022 were collected, 35 of them were included. The patients were divided in two groups: Group H (1 MAC, n:18) and Group L (0.5 MAC, n:17). All patients were prepared and managed in line with ERAS protocols. Perioperative and early postoperative parameters including depth of anesthesia which was followed by PSI (Pneumonia Severity Index) and SR (Supression Ratio), preoperative and postoperative 24th hours Mini Mental Test results, post-anesthesia care unit (PACU) unit admission and duration and complications were compared. Results: The mean age of the patients (61 and 65 years, in the Group H and L, respectively) were similar (p=0.234) in both groups. PSI was found to be significantly lower in Group H at the 60th, 120th minutes and fascia closure (p=0.004, p=0.001, and p=0.000 respectively). PSI <25 duration was significantly higher in group H (139.0±186.7 and 17.6±54.8 in group H and L, respectively, p=0.001). The duration of SR>0 was significantly higher in Group H (p=0.000). Both anesthesia (474 min) and surgery (432 min) times were significantly higher in Group H (p=0.013 and 0.029 respectivelly). Nausea and vomiting at 12 hours postoperatively was also common in Group H (p=0.008). The rest of parameters that compared were similar, including the minimental test. Conclusion: The MAC values did not significantly affect perioperative and early postoperative outcomes. While high MAC level MAC level generates a deeper anesthesia, low MAC level seems an effective alternative providig a lower inhalation anestesia agent consumption.
{"title":"Does Depth of Anesthesia Effect Clinical Results of Patients Who Underwent Radical Cystectomy in Accordance with Eras Protocols?","authors":"Nalan SAYGI EMİR, Fatma ÇITAK KARACAER","doi":"10.33719/yud.2023-18-3-1350497","DOIUrl":"https://doi.org/10.33719/yud.2023-18-3-1350497","url":null,"abstract":"Objective: To investigated whether low and high MAC (Minimum Aleveolar Concentration) level of anesthesia have an effect on the depth of anesthesia, clinical results paremeters in patients underwent radical cystectomy in accordance with ERAS (Enhanced Recovery After Surgery) protocols Material and Methods: Retrospective data of 41 patients underwent radical cystectomy between 2019-2022 were collected, 35 of them were included. The patients were divided in two groups: Group H (1 MAC, n:18) and Group L (0.5 MAC, n:17). All patients were prepared and managed in line with ERAS protocols. Perioperative and early postoperative parameters including depth of anesthesia which was followed by PSI (Pneumonia Severity Index) and SR (Supression Ratio), preoperative and postoperative 24th hours Mini Mental Test results, post-anesthesia care unit (PACU) unit admission and duration and complications were compared. Results: The mean age of the patients (61 and 65 years, in the Group H and L, respectively) were similar (p=0.234) in both groups. PSI was found to be significantly lower in Group H at the 60th, 120th minutes and fascia closure (p=0.004, p=0.001, and p=0.000 respectively). PSI <25 duration was significantly higher in group H (139.0±186.7 and 17.6±54.8 in group H and L, respectively, p=0.001). The duration of SR>0 was significantly higher in Group H (p=0.000). Both anesthesia (474 min) and surgery (432 min) times were significantly higher in Group H (p=0.013 and 0.029 respectivelly). Nausea and vomiting at 12 hours postoperatively was also common in Group H (p=0.008). The rest of parameters that compared were similar, including the minimental test. Conclusion: The MAC values did not significantly affect perioperative and early postoperative outcomes. While high MAC level MAC level generates a deeper anesthesia, low MAC level seems an effective alternative providig a lower inhalation anestesia agent consumption.","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"23 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.33719/yud.2023;18-3-1287231
Tuğçem BIÇAK, Selver ÖZŞENER ÖZEKİNCİ, Yekta BIÇAK, Mansur DAĞGÜLLİ
The majority of bladder lesions are papillary and/or flat-appearing urothelial neoplasms. Neoplasms besides urothelial tumors are very rare. Paragangliomas are rare catecholamine-releasing tumors of sympathetic ganglion or chromaffin cell origin. Approximately 10% of paragangliomas occur in the non-adrenal region, of which 10% are seen in the bladder and constitute 0.05% of all bladder tumors. In a 42-year-old female patient, a 50x43 mm solid mass protruding into the lumen on the left anterolateral aspect of the bladder was observed with necrotic center and increased vascularity on the periphery. The specimens of the TUR material obtained from an external center and our hospital were examined by pathology and diagnosed as paraganglioma. Because of its rarity and confusion with urothelial carcinoma, paraganglioma should always be kept in mind when dealing with bladder tumors.
{"title":"Paraganglioma of Urinary Bladder: A Case Report","authors":"Tuğçem BIÇAK, Selver ÖZŞENER ÖZEKİNCİ, Yekta BIÇAK, Mansur DAĞGÜLLİ","doi":"10.33719/yud.2023;18-3-1287231","DOIUrl":"https://doi.org/10.33719/yud.2023;18-3-1287231","url":null,"abstract":"The majority of bladder lesions are papillary and/or flat-appearing urothelial neoplasms. Neoplasms besides urothelial tumors are very rare. Paragangliomas are rare catecholamine-releasing tumors of sympathetic ganglion or chromaffin cell origin. Approximately 10% of paragangliomas occur in the non-adrenal region, of which 10% are seen in the bladder and constitute 0.05% of all bladder tumors. In a 42-year-old female patient, a 50x43 mm solid mass protruding into the lumen on the left anterolateral aspect of the bladder was observed with necrotic center and increased vascularity on the periphery. The specimens of the TUR material obtained from an external center and our hospital were examined by pathology and diagnosed as paraganglioma. Because of its rarity and confusion with urothelial carcinoma, paraganglioma should always be kept in mind when dealing with bladder tumors.","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"11 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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