Pub Date : 2023-02-27DOI: 10.33719/yud.2023;18-1-1215737
M. Kılıç, S. Madendere, Arzu Baygül Eden, F. Tekkalan, E. Köseoğlu, M. Balbay
Objective: This study aimed to assess the urethrovesical anastomotic leakage (UAL) and associated factors in patients who underwent robot-assisted radical prostatectomy (RARP) and its effect on early continence. Material and Methods: The data of 81 patients who underwent RARP between February 2017 and June 2022 were evaluated in this retrospective analysis. On the seventh postoperative day, we performed a cystography to determine whether the patients had UAL. Uni- and multivariate analyses were done to investigate the factors that could lead to UAL. Continence rates were recorded in patients at 6-12 weeks after surgery. Results: Overall 25 patients (31%) had UAL; of them 12 (15%) were mild, eight (10%) were moderate, and five (6%) were extensive. A drain/ serum creatinine ratio >1.5 and a prostate volume >53 cm3 were determined to be significant in predicting UAL in both the uni- and multivariate analyses (p=0.017 and p=0.046, respectively). On the postoperative second or third day, of the 36 patients who had drain output greater than 100 ml, eight (22%) had a high drain/serum creatinine ratio (>1.5), seven (88%) of which had UAL. According to the early period follow-up data, incontinence was prevalent in 9 (36%) of the patients with UAL and 20 (%37) of the patients without UAL (p=0.959). Conclusion: Cystography is an effective method for detecting leakage after RARP. A large prostate volume (>53 cm3) and a high postoperative drain/serum creatinine ratio (>1.5) were found to be associated with UAL. UAL had no effect on early continence. Keywords: anastomotic leak, cystography, prostatectomy, robot-assisted, urinary incontinence
{"title":"Impact of urethrovesical anastomotic leakage after robotic radical prostatectomy on early postoperative continence","authors":"M. Kılıç, S. Madendere, Arzu Baygül Eden, F. Tekkalan, E. Köseoğlu, M. Balbay","doi":"10.33719/yud.2023;18-1-1215737","DOIUrl":"https://doi.org/10.33719/yud.2023;18-1-1215737","url":null,"abstract":"Objective: This study aimed to assess the urethrovesical anastomotic leakage (UAL) and associated factors in patients who underwent robot-assisted radical prostatectomy (RARP) and its effect on early continence. Material and Methods: The data of 81 patients who underwent RARP between February 2017 and June 2022 were evaluated in this retrospective analysis. On the seventh postoperative day, we performed a cystography to determine whether the patients had UAL. Uni- and multivariate analyses were done to investigate the factors that could lead to UAL. Continence rates were recorded in patients at 6-12 weeks after surgery. Results: Overall 25 patients (31%) had UAL; of them 12 (15%) were mild, eight (10%) were moderate, and five (6%) were extensive. A drain/ serum creatinine ratio >1.5 and a prostate volume >53 cm3 were determined to be significant in predicting UAL in both the uni- and multivariate analyses (p=0.017 and p=0.046, respectively). On the postoperative second or third day, of the 36 patients who had drain output greater than 100 ml, eight (22%) had a high drain/serum creatinine ratio (>1.5), seven (88%) of which had UAL. According to the early period follow-up data, incontinence was prevalent in 9 (36%) of the patients with UAL and 20 (%37) of the patients without UAL (p=0.959). Conclusion: Cystography is an effective method for detecting leakage after RARP. A large prostate volume (>53 cm3) and a high postoperative drain/serum creatinine ratio (>1.5) were found to be associated with UAL. UAL had no effect on early continence. Keywords: anastomotic leak, cystography, prostatectomy, robot-assisted, urinary incontinence","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"555 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-27DOI: 10.33719/yud.2023;18-1-1129666
I. Evren, Y. O. Danacıoğlu, M. Ekşi, D. N. Özlü, A. Hacıislamoğlu, Y. Arıkan, Ã. Ayten, H. Polat
Objective: Prostate cancer (PCa) is the most common malignancy in men and early diagnosis can be made by screening. Active surveillance (AS) is one of the options for disease management in patients with low-risk prostate cancer (LRPC). In this study, we aimed to evaluate our clinical experience in AS for prostate cancer. Material and Methods: Data from 1650 patients who were diagnosed with PCa in the period between January 2014 and December 2019, were retrospectively reviewed. Inclusion criteria were defined as being under 75 years of age and having a 10-year life expectancy, being at clinical stages of T1-T2a, having a PSA level of <10 ng/dl, having positive biopsy cores of ≤2, and having a Gleason score of ≤6 as the result of the pathological examination of the biopsy specimen. Patients not meeting any of the inclusion criteria were excluded from the study. Results: After the inclusion and exclusion criteria, 176 patients agreed to undergo AS and were included in the study. The mean follow-up duration was 25.2 ± 13 months. A total of 57 patients (32.3%) left the AS program to undergo definitive treatment. Definitive treatment was radical prostatectomy in 38 (65.5%) patients, radiotherapy in 18 (31%) patients, and hormonotherapy in one (1.7%) patient. Conclusion: AS is a method that helps avoid the complications of definitive treatment in LRPC patients. It can be used as an alternative option to definitive treatment in the management of these patients. However, it should not be forgotten that pathological upgrades may occur in 30% of AS patients, indicating the need for definitive treatment. Keywords: prostate cancer, active surveillance, low-risk prostate cancer
{"title":"At what stage are we in active surveillance for localized prostate cancer? Our clinical experience","authors":"I. Evren, Y. O. Danacıoğlu, M. Ekşi, D. N. Özlü, A. Hacıislamoğlu, Y. Arıkan, Ã. Ayten, H. Polat","doi":"10.33719/yud.2023;18-1-1129666","DOIUrl":"https://doi.org/10.33719/yud.2023;18-1-1129666","url":null,"abstract":"Objective: Prostate cancer (PCa) is the most common malignancy in men and early diagnosis can be made by screening. Active surveillance (AS) is one of the options for disease management in patients with low-risk prostate cancer (LRPC). In this study, we aimed to evaluate our clinical experience in AS for prostate cancer. Material and Methods: Data from 1650 patients who were diagnosed with PCa in the period between January 2014 and December 2019, were retrospectively reviewed. Inclusion criteria were defined as being under 75 years of age and having a 10-year life expectancy, being at clinical stages of T1-T2a, having a PSA level of <10 ng/dl, having positive biopsy cores of ≤2, and having a Gleason score of ≤6 as the result of the pathological examination of the biopsy specimen. Patients not meeting any of the inclusion criteria were excluded from the study. Results: After the inclusion and exclusion criteria, 176 patients agreed to undergo AS and were included in the study. The mean follow-up duration was 25.2 ± 13 months. A total of 57 patients (32.3%) left the AS program to undergo definitive treatment. Definitive treatment was radical prostatectomy in 38 (65.5%) patients, radiotherapy in 18 (31%) patients, and hormonotherapy in one (1.7%) patient. Conclusion: AS is a method that helps avoid the complications of definitive treatment in LRPC patients. It can be used as an alternative option to definitive treatment in the management of these patients. However, it should not be forgotten that pathological upgrades may occur in 30% of AS patients, indicating the need for definitive treatment. Keywords: prostate cancer, active surveillance, low-risk prostate cancer","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-27DOI: 10.33719/yud.2023;18-1-1230358
O. Açıkgöz, Mert Altınel
Objective: Kidney transplantation (KTx) is the most effective treatment option for patients with end-stage renal disease (ESRD). Live donor kidney transplantation is unique as it involves healthy individuals who undergo a major surgery. This retrospective study seeks to investigate the effect of donor–recipient relationship on postoperative outcomes in Turkish donors undergoing laparoscopic donor nephrectomy (DNx). Material and Methods: The study was conducted with a total of 297 patients who underwent left DNx. The patients included in the study were divided into six different groups based on the degree of relationship with the recipients: Sixty-nine cases of DNx involved mothers as kidney donors classified into group-1, 29 cases involving fathers into group-2, 70 cases involving spouses into group-3, 68 cases involving siblings into group-4, 31 cases involving children into group-5, and 30 cases involving second-degree and more distant relatives into group-6. Patients’ data including age, sex, education level, duration of surgery (ST), Visual Analog Scale (VAS) pain score at postoperative day 1, length of hospital stay (HS), and Quality of Life (QoL) were retrospectively analyzed and recorded. Results: The groups had significant differences in terms of VAS scores, HS, and QoL-MS. Posthoc analysis was performed to find out which groups had significant differences. Results showed that group-1 had significantly lower VAS scores than group-2, group-3, and group-6. HS was significantly long in group-3 and group-6. QoL-MSwas significantly lower in group-2 and group-6 than the other groups. Conclusion: The degree of relationship of living kidney donors to recipients influences their psychological health in the early postoperative period and probably affects VAS scores and length of hospital stay. It can be argued that mothers are the group of donors least affected by the kidney donation process. Keywords: kidney; transplantation; live donor; donor-recipient relationship
{"title":"Demographic characteristics of Turkish kidney donors and the impact of donor-recipient relationship on postoperative outcomes: A single-center experience","authors":"O. Açıkgöz, Mert Altınel","doi":"10.33719/yud.2023;18-1-1230358","DOIUrl":"https://doi.org/10.33719/yud.2023;18-1-1230358","url":null,"abstract":"Objective: Kidney transplantation (KTx) is the most effective treatment option for patients with end-stage renal disease (ESRD). Live donor kidney transplantation is unique as it involves healthy individuals who undergo a major surgery. This retrospective study seeks to investigate the effect of donor–recipient relationship on postoperative outcomes in Turkish donors undergoing laparoscopic donor nephrectomy (DNx). Material and Methods: The study was conducted with a total of 297 patients who underwent left DNx. The patients included in the study were divided into six different groups based on the degree of relationship with the recipients: Sixty-nine cases of DNx involved mothers as kidney donors classified into group-1, 29 cases involving fathers into group-2, 70 cases involving spouses into group-3, 68 cases involving siblings into group-4, 31 cases involving children into group-5, and 30 cases involving second-degree and more distant relatives into group-6. Patients’ data including age, sex, education level, duration of surgery (ST), Visual Analog Scale (VAS) pain score at postoperative day 1, length of hospital stay (HS), and Quality of Life (QoL) were retrospectively analyzed and recorded. Results: The groups had significant differences in terms of VAS scores, HS, and QoL-MS. Posthoc analysis was performed to find out which groups had significant differences. Results showed that group-1 had significantly lower VAS scores than group-2, group-3, and group-6. HS was significantly long in group-3 and group-6. QoL-MSwas significantly lower in group-2 and group-6 than the other groups. Conclusion: The degree of relationship of living kidney donors to recipients influences their psychological health in the early postoperative period and probably affects VAS scores and length of hospital stay. It can be argued that mothers are the group of donors least affected by the kidney donation process. Keywords: kidney; transplantation; live donor; donor-recipient relationship","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-27DOI: 10.33719/yud.2023;18-1-1225314
Aslıhan Ergül, Ufuk Çağlar
Objective: To evaluate the characteristics of men who support their partners in getting the HPV vaccine. Material And Methods: All married women (< 26 years) who were admitted to the gynecology outpatient clinic and their husbands were evaluated for participation in the study. Patients’ and all characteristics of male partners were recorded. All male participants answered a survey form including ten statements about HPV and HPV vaccination. Male participants were divided into two groups according to their support or lack of support for HPV vaccination of their wife. Results: In total, 92 men supported HPV vaccination for their partners and 144 men opposed HPV vaccination (support rate: 39%). The mean marriage age, education status and monthly income were significantly higher in favor of men who support HPV vaccination for their wives. The rate of those who stated they were religious was significantly higher in the anti-vaccine group. Safety concerns about vaccine (27.8%), cost of vaccine (26.4%) and belief about HPV vaccine effectiveness (26.4%) were most common reasons for opposing HPV vaccination. Multivariate regression analysis revealed marriage age ≥25 years, education level of high school and university, higher monthly income and not self-identification as religious increased the HPV vaccine support rate. Conclusion: The present study found that men with higher marriage age, higher educational level, higher monthly income, and higher score on the HPV survey were significantly more supportive of their spouses getting the HPV vaccination. In contrast, men who identified themselves as religious had significantly less support for their wife being vaccinated. Keywords: vaccine, immunity, genital wart, human papilloma virus, cervical cancer
{"title":"Male partner characteristics providing support for HPV vaccination of married women","authors":"Aslıhan Ergül, Ufuk Çağlar","doi":"10.33719/yud.2023;18-1-1225314","DOIUrl":"https://doi.org/10.33719/yud.2023;18-1-1225314","url":null,"abstract":"Objective: To evaluate the characteristics of men who support their partners in getting the HPV vaccine. Material And Methods: All married women (< 26 years) who were admitted to the gynecology outpatient clinic and their husbands were evaluated for participation in the study. Patients’ and all characteristics of male partners were recorded. All male participants answered a survey form including ten statements about HPV and HPV vaccination. Male participants were divided into two groups according to their support or lack of support for HPV vaccination of their wife. Results: In total, 92 men supported HPV vaccination for their partners and 144 men opposed HPV vaccination (support rate: 39%). The mean marriage age, education status and monthly income were significantly higher in favor of men who support HPV vaccination for their wives. The rate of those who stated they were religious was significantly higher in the anti-vaccine group. Safety concerns about vaccine (27.8%), cost of vaccine (26.4%) and belief about HPV vaccine effectiveness (26.4%) were most common reasons for opposing HPV vaccination. Multivariate regression analysis revealed marriage age ≥25 years, education level of high school and university, higher monthly income and not self-identification as religious increased the HPV vaccine support rate. Conclusion: The present study found that men with higher marriage age, higher educational level, higher monthly income, and higher score on the HPV survey were significantly more supportive of their spouses getting the HPV vaccination. In contrast, men who identified themselves as religious had significantly less support for their wife being vaccinated. Keywords: vaccine, immunity, genital wart, human papilloma virus, cervical cancer","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48470606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-27DOI: 10.33719/yud.2023;18-1-1123079
O. Can, S. Cakir, Ç. Vural, C. Eraldemir, M. Çekmen, A. Ötünçtemur
Objective: Montelukast, an asthma drug, has an anti-inflammatory effect on tissues. We aimed to investigate therapeutic effect of montelukast (MK) on acetaminophen (APAP) - induced renal damage in rat models. Material and Methods: Twenty-four rats were randomly divided into four groups of six animals each. APAP was administered intraperitoneally as a single dose of 1000 mg/kg/day. In the treatment group, MK dose was 10 mg/kg and administered by oral gavage after APAP. The other groups were APAP + Saline group and the control group. We measured tissue malondialdehyde (MDA), reduced glutathione (GSH), and Nitric oxide (NO) levels to determine the nephrotoxicity. Results: Serum Blood Urea Nitrogen (BUN) and creatinine levels were measured significantly higher in APAP group than rats in the control and APAP + MK groups. The level of GSH was significantly diminished in APAP-treated rats. However, the administration of MK significantly increased the level of GSH in the MK treatment group. Tissue MDA levels in rats treated with APAP alone were significantly higher compared to the control group and APAP + MK group. The level of NO was measured as elevated in APAP treated group. However, NO levels in the MK treatment group were significantly lower than APAP treated group. Furthermore, some morphological recoveries were observed in the MK treatment group compared to APAP alone group. Conclusion: MK has beneficial effects on APAP-induced renal toxicity and dysfunction. However, clinical studies are needed to demonstrate appropriate use and effects. Keywords: acetaminophen, kidney, montelukast, nephrotoxicity, oxidative stress
{"title":"Preventive effects of montelukast against acetaminophen-induced nephrotoxicity: An experimental study","authors":"O. Can, S. Cakir, Ç. Vural, C. Eraldemir, M. Çekmen, A. Ötünçtemur","doi":"10.33719/yud.2023;18-1-1123079","DOIUrl":"https://doi.org/10.33719/yud.2023;18-1-1123079","url":null,"abstract":"Objective: Montelukast, an asthma drug, has an anti-inflammatory effect on tissues. We aimed to investigate therapeutic effect of montelukast (MK) on acetaminophen (APAP) - induced renal damage in rat models. Material and Methods: Twenty-four rats were randomly divided into four groups of six animals each. APAP was administered intraperitoneally as a single dose of 1000 mg/kg/day. In the treatment group, MK dose was 10 mg/kg and administered by oral gavage after APAP. The other groups were APAP + Saline group and the control group. We measured tissue malondialdehyde (MDA), reduced glutathione (GSH), and Nitric oxide (NO) levels to determine the nephrotoxicity. Results: Serum Blood Urea Nitrogen (BUN) and creatinine levels were measured significantly higher in APAP group than rats in the control and APAP + MK groups. The level of GSH was significantly diminished in APAP-treated rats. However, the administration of MK significantly increased the level of GSH in the MK treatment group. Tissue MDA levels in rats treated with APAP alone were significantly higher compared to the control group and APAP + MK group. The level of NO was measured as elevated in APAP treated group. However, NO levels in the MK treatment group were significantly lower than APAP treated group. Furthermore, some morphological recoveries were observed in the MK treatment group compared to APAP alone group. Conclusion: MK has beneficial effects on APAP-induced renal toxicity and dysfunction. However, clinical studies are needed to demonstrate appropriate use and effects. Keywords: acetaminophen, kidney, montelukast, nephrotoxicity, oxidative stress","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47615803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-27DOI: 10.33719/yud.2023;18-1-1118339
Kaan Karamık, Mehmet Kısaarslan, H. Anıl, N. Ateş
Objective: This study aimed to compare the efficacy of tamsulosin and silodosin as medical expulsive therapy in patients with symptomatic uncomplicated distal ureteric stones. Material and Methods: The data of adult patients who had distal ureteric stones in size between 4 and 10 mm and were treated with medical expulsive therapy between June 2019 and January 2022 were retrospectively documented. Patients were divided into two groups. Patients in Group 1 received silodosin 4 mg, and Group 2 received tamsulosin 0.4 mg. Therapy was given for a maximum of 3 weeks. Stone expulsion rate, time to stone expulsion, stone burden, and stone size were recorded. The efficacy of tamsulosin and silodosin as adjunctive medical therapy was determined. Results: A total of 152 patients were included in the study. Demographic profiles were comparable between the 2 groups. 116 (76.3%) patients were stone-free at the end of the follow-up. The stone expulsion rate was calculated in 47 patients (73.4%) in Group 1, and 69 patients (78.4%) in Group 2 (P = 0.477). The distance of the stone to the ureterovesical junction was significantly associated with successful stone expulsion in multivariate analysis (P=0.032). Conclusion: There was no significant superiority between tamsulosin and silodosin as medical expulsive therapy for distal ureteral stones. The distance of the stone to the ureterovesical junction was the only independent predictor of stone expulsion in multivariate analysis. Keywords: Medical expulsive therapy,
{"title":"Efficacy of tamsulosin versus silodosin as medical expulsive therapy on stone expulsion in patients with distal ureteral stone: A retrospective single center study","authors":"Kaan Karamık, Mehmet Kısaarslan, H. Anıl, N. Ateş","doi":"10.33719/yud.2023;18-1-1118339","DOIUrl":"https://doi.org/10.33719/yud.2023;18-1-1118339","url":null,"abstract":"Objective: This study aimed to compare the efficacy of tamsulosin and silodosin as medical expulsive therapy in patients with symptomatic uncomplicated distal ureteric stones. Material and Methods: The data of adult patients who had distal ureteric stones in size between 4 and 10 mm and were treated with medical expulsive therapy between June 2019 and January 2022 were retrospectively documented. Patients were divided into two groups. Patients in Group 1 received silodosin 4 mg, and Group 2 received tamsulosin 0.4 mg. Therapy was given for a maximum of 3 weeks. Stone expulsion rate, time to stone expulsion, stone burden, and stone size were recorded. The efficacy of tamsulosin and silodosin as adjunctive medical therapy was determined. Results: A total of 152 patients were included in the study. Demographic profiles were comparable between the 2 groups. 116 (76.3%) patients were stone-free at the end of the follow-up. The stone expulsion rate was calculated in 47 patients (73.4%) in Group 1, and 69 patients (78.4%) in Group 2 (P = 0.477). The distance of the stone to the ureterovesical junction was significantly associated with successful stone expulsion in multivariate analysis (P=0.032). Conclusion: There was no significant superiority between tamsulosin and silodosin as medical expulsive therapy for distal ureteral stones. The distance of the stone to the ureterovesical junction was the only independent predictor of stone expulsion in multivariate analysis. Keywords: Medical expulsive therapy,","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-27DOI: 10.33719/yud.2023;18-1-1193181
A. Hacıislamoğlu, A. Yavuzsan
Objective: To evaluate the efficacy of tadalafil 5mg+solifenacin 5mg combination in terms of lower urinary tract symptoms (LUTS) and erectile functions in benign prostate hyperplasia patients with predominant storage symptoms. Material and Methods: Male patients over the age of 40 who presented with LUTS with predominant storage symptoms between January 2019 and December 2021 were included into the study. Daily tadalafil 5mg and solifenacin 5mg treatment were started to the patients. Overactive bladder symptom score (OABSS), international prostate symptom score (IPSS) for LUTS, and international erectile function index-erectile function (IIEF-EF) questionnaires were used for erectile function. Frequency of daily urinary frequency, frequency of nocturia, urgency and urinary incontinence were analyzed with a three-day bladder diary. Twelve weeks later, IPSS, OABSS and IIEF-EF scores of the patients were evaluated. Results: When the symptom scores and bladder diaries of the patients before and after 12 weeks of treatment were compared, significant decrease in IPSS scores (both voiding, storage and total) (p<0.001 for each), significant increase in IIEF-EF scores (p<0.001), and significant increase in Qmax value elevation was observed. When the bladder diaries were compared, the number of daytime micturitions, the number of nocturia and the number of urgency decreased in the 12th month after tadalafil+solifenacin treatment (p<0.001). Conclusion: The combination of tadalafil 5mg and solifenacin 5mg daily is an effective and safe treatment for male patients with storage symptoms predominant LUTS/ED. Keywords: benign prostate hyperplasia, storage, tadalafil, solifenacin, erectile function
{"title":"Efficacy of combination of daily tadalafil and solifenacin in patients with storage symptom predominant lower urinary tract symptoms","authors":"A. Hacıislamoğlu, A. Yavuzsan","doi":"10.33719/yud.2023;18-1-1193181","DOIUrl":"https://doi.org/10.33719/yud.2023;18-1-1193181","url":null,"abstract":"Objective: To evaluate the efficacy of tadalafil 5mg+solifenacin 5mg combination in terms of lower urinary tract symptoms (LUTS) and erectile functions in benign prostate hyperplasia patients with predominant storage symptoms. Material and Methods: Male patients over the age of 40 who presented with LUTS with predominant storage symptoms between January 2019 and December 2021 were included into the study. Daily tadalafil 5mg and solifenacin 5mg treatment were started to the patients. Overactive bladder symptom score (OABSS), international prostate symptom score (IPSS) for LUTS, and international erectile function index-erectile function (IIEF-EF) questionnaires were used for erectile function. Frequency of daily urinary frequency, frequency of nocturia, urgency and urinary incontinence were analyzed with a three-day bladder diary. Twelve weeks later, IPSS, OABSS and IIEF-EF scores of the patients were evaluated. Results: When the symptom scores and bladder diaries of the patients before and after 12 weeks of treatment were compared, significant decrease in IPSS scores (both voiding, storage and total) (p<0.001 for each), significant increase in IIEF-EF scores (p<0.001), and significant increase in Qmax value elevation was observed. When the bladder diaries were compared, the number of daytime micturitions, the number of nocturia and the number of urgency decreased in the 12th month after tadalafil+solifenacin treatment (p<0.001). Conclusion: The combination of tadalafil 5mg and solifenacin 5mg daily is an effective and safe treatment for male patients with storage symptoms predominant LUTS/ED. Keywords: benign prostate hyperplasia, storage, tadalafil, solifenacin, erectile function","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-27DOI: 10.33719/yud.2023;18-1-1118829
E. Kandemir, K. Toprak, A. Tahra, Ö. Efiloğlu, G. Atis, A. Yıldırım
Objective: It was aimed to compare the methods of local anesthesia and general anesthesia with circumcision study questionnaire applied before and after circumcision. Material and Methods: Parents of children aged 0-12 years who applied for circumcision between June and December 2021 who agreed to participate in the study were asked to fill out the circumcision study questionnaire. All patients were operated with same surgeon and surgical method. Patients were divided into local and general anesthesia groups, and data were compared. Results: Our study included 282 patients; general anesthesia was applied to 132 patients (48.9%), and local anesthesia was applied to 144 patients (51.1%). Age and weight averages of patients who were administered local anesthesia and age preferences suitable for circumcision were significantly lower than those in general anesthesia group (p:0.001). There was no significant difference between socioeconomic levels, educational status and reasons for circumcision in both groups (p≥0.05). Patients’ need for postoperative care and recovery time was significantly lower in the local anesthesia group (p:0.001). Conclusion: Circumcision is a surgical operation that can be performed safely with local or general anesthesia. Parents who want circumcision in the early months of life mostly prefer local anesthesia. Postoperative recovery time is shorter in this group. Preference for anesthesia has changed in favor of general anesthesia in advanced ages, including the sexual development period. The knowledge and awareness level of our society about circumcision has increased compared to previous years. Keywords: circumcision, local anesthesia, general anesthesia, urinary tract infection
{"title":"What is the best anesthesia method for circumcision? Comparison of local and general anesthesia: Prospective clinical study","authors":"E. Kandemir, K. Toprak, A. Tahra, Ö. Efiloğlu, G. Atis, A. Yıldırım","doi":"10.33719/yud.2023;18-1-1118829","DOIUrl":"https://doi.org/10.33719/yud.2023;18-1-1118829","url":null,"abstract":"Objective: It was aimed to compare the methods of local anesthesia and general anesthesia with circumcision study questionnaire applied before and after circumcision. Material and Methods: Parents of children aged 0-12 years who applied for circumcision between June and December 2021 who agreed to participate in the study were asked to fill out the circumcision study questionnaire. All patients were operated with same surgeon and surgical method. Patients were divided into local and general anesthesia groups, and data were compared. Results: Our study included 282 patients; general anesthesia was applied to 132 patients (48.9%), and local anesthesia was applied to 144 patients (51.1%). Age and weight averages of patients who were administered local anesthesia and age preferences suitable for circumcision were significantly lower than those in general anesthesia group (p:0.001). There was no significant difference between socioeconomic levels, educational status and reasons for circumcision in both groups (p≥0.05). Patients’ need for postoperative care and recovery time was significantly lower in the local anesthesia group (p:0.001). Conclusion: Circumcision is a surgical operation that can be performed safely with local or general anesthesia. Parents who want circumcision in the early months of life mostly prefer local anesthesia. Postoperative recovery time is shorter in this group. Preference for anesthesia has changed in favor of general anesthesia in advanced ages, including the sexual development period. The knowledge and awareness level of our society about circumcision has increased compared to previous years. Keywords: circumcision, local anesthesia, general anesthesia, urinary tract infection","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-27DOI: 10.33719/yud.2023;18-1-1188129
Ümit Yıldırım, Mehmet Uslu, M. Ezer, Rasim Güzel, K. Sarıca
Objective: This study’s main goal was to evaluate the possible impact of different-sized double-J (DJ) stents on the pain and stone-free status following flexible ureteroscopic laser disintegration (fURS) of renal stones. Material and Methods: A total of 104 patients who underwent fURS for kidney stones were included in our study. In 51 patients, a 4.7 Fr DJ stent was used after stone fragmentation, while in the remaining 53 cases, a 6 Fr stent was chosen. Between the two groups, general pain symptoms were evaluated using a visual pain scale at the end of the first postoperative week. The stone-free status was evaluated using non-contrast computed tomography (NCCT) after three months following surgery. Success was determined by either the complete clearance of the stones or the presence of small stone fragments (<3 mm). Results: Using a visual pain scale, we compared the two groups’ overall reports of pain (4.02±1.10 vs 4.81±1.53, p=0.006). When we looked at the stone-free rates, the two groups were not significantly different in this regard (84.3% vs 74.5%, p=0.264). We found no statistically significant difference between the two groups in terms of postoperative fever, stent migration, or visits to the emergency room. Conclusion: In spite of the fact that larger diameter stents resulted in more pain complaints for patients, they did not alter the long-term stone-free rates appreciably, as evidenced by our findings. In order to reduce the occurrence of unpleasant symptoms, a 4.7 Fr double-j stent may be preferable over a 6 Fr stent following flexible ureteroscopic surgery. Keywords: Double-j stent diameter, renal stones, flexible ureterorenoscopy, stone free
目的:本研究的主要目的是评估不同大小的双j (DJ)支架对输尿管软镜激光崩解(fURS)肾结石后疼痛和无结石状态的可能影响。材料和方法:我们的研究共纳入了104例因肾结石接受fURS治疗的患者。51例患者结石碎裂后使用4.7 Fr DJ支架，其余53例患者选择6 Fr支架。在两组之间，术后第一周结束时使用视觉疼痛量表评估一般疼痛症状。术后3个月用非对比计算机断层扫描(NCCT)评估无结石状态。成功与否取决于是否完全清除石块或是否存在小石块碎片(<3毫米)。结果:采用视觉疼痛量表比较两组患者总体疼痛报告(4.02±1.10 vs 4.81±1.53,p=0.006)。当我们观察无结石率时，两组在这方面没有显著差异(84.3% vs 74.5%， p=0.264)。我们发现两组在术后发热、支架移位或急诊室就诊方面无统计学差异。结论:正如我们的研究结果所证明的那样，尽管大直径支架导致患者更多的疼痛投诉，但它们并没有明显改变长期无结石率。为了减少不愉快症状的发生，输尿管镜手术后，4.7 Fr双j支架可能比6 Fr支架更可取。关键词:双j型支架直径;肾结石;输尿管镜
{"title":"Long-term stone-free rates after flexible URS: Does the size of DJ stent affect the outcomes","authors":"Ümit Yıldırım, Mehmet Uslu, M. Ezer, Rasim Güzel, K. Sarıca","doi":"10.33719/yud.2023;18-1-1188129","DOIUrl":"https://doi.org/10.33719/yud.2023;18-1-1188129","url":null,"abstract":"Objective: This study’s main goal was to evaluate the possible impact of different-sized double-J (DJ) stents on the pain and stone-free status following flexible ureteroscopic laser disintegration (fURS) of renal stones. Material and Methods: A total of 104 patients who underwent fURS for kidney stones were included in our study. In 51 patients, a 4.7 Fr DJ stent was used after stone fragmentation, while in the remaining 53 cases, a 6 Fr stent was chosen. Between the two groups, general pain symptoms were evaluated using a visual pain scale at the end of the first postoperative week. The stone-free status was evaluated using non-contrast computed tomography (NCCT) after three months following surgery. Success was determined by either the complete clearance of the stones or the presence of small stone fragments (<3 mm). Results: Using a visual pain scale, we compared the two groups’ overall reports of pain (4.02±1.10 vs 4.81±1.53, p=0.006). When we looked at the stone-free rates, the two groups were not significantly different in this regard (84.3% vs 74.5%, p=0.264). We found no statistically significant difference between the two groups in terms of postoperative fever, stent migration, or visits to the emergency room. Conclusion: In spite of the fact that larger diameter stents resulted in more pain complaints for patients, they did not alter the long-term stone-free rates appreciably, as evidenced by our findings. In order to reduce the occurrence of unpleasant symptoms, a 4.7 Fr double-j stent may be preferable over a 6 Fr stent following flexible ureteroscopic surgery. Keywords: Double-j stent diameter, renal stones, flexible ureterorenoscopy, stone free","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-27DOI: 10.33719/yud.2023;18-1-1204096
T. Kargı, A. Bitkin, Ubeyd Sungur, S. Karadağ, I. Evren, A. Hacıislamoğlu, H. Polat, Necati Gürbüz, A. Taşçı
Objective: In this study, we aimed to evaluate the effect of large prostate volume on surgical, oncological and functional outcomes in prostate cancer patients who underwent Robot-assisted radical prostatectomy (RARP). Material and Methods: In this study, patients who underwent RARP due to prostate cancer by a single surgeon were divided into two groups as large prostate volume over 75 cc (Group-1) and prostate volume less than 75 cc (Group-2), and these two groups were compared retrospectively. Patients who were followed up for 12 months were assessed. Results: There was no significant difference between the two groups in terms of age, preoperative PSA level, clinical stage distributions, Gleason score, D’Amico risk classification, preoperative potency and continence assessment (p>0.05). The operative time was 169.9 ± 62.5 minutes and 145.6 ± 56.1 minutes in Groups 1 and 2, respectively, and was significantly higher in Group 1 (p= 0.02). Bladder neck reconstruction was performed in 17 (35%) and 2 (3%) patients in Groups 1 and 2, respectively, and it was statistically significantly higher in Group-1 (p=0.001). After removal of the urethral catheter in Group 1 and Group 2, full continence and potency rates were similar during the 1-year follow-up (p >0.05). Biochemical recurrence rates at 6 months and 1 year were similar in Group 1 and Group 2 (p >0.05). Conclusion: In prostate cancer patients with large prostate volume, RARP results in longer operative time and bladder neck reconstruction may be required.. However, in operations performed by experienced surgeons, large prostate volume does not have a negative effect on surgical, functional and oncological outcomes. Keywords: robotic surgical procedures, prostatectomy, prostate, organ size
{"title":"Effect of large prostate volume on perioperative, oncological and functional outcomes after robotic radical prostatectomy: A retrospective clinical study","authors":"T. Kargı, A. Bitkin, Ubeyd Sungur, S. Karadağ, I. Evren, A. Hacıislamoğlu, H. Polat, Necati Gürbüz, A. Taşçı","doi":"10.33719/yud.2023;18-1-1204096","DOIUrl":"https://doi.org/10.33719/yud.2023;18-1-1204096","url":null,"abstract":"Objective: In this study, we aimed to evaluate the effect of large prostate volume on surgical, oncological and functional outcomes in prostate cancer patients who underwent Robot-assisted radical prostatectomy (RARP). Material and Methods: In this study, patients who underwent RARP due to prostate cancer by a single surgeon were divided into two groups as large prostate volume over 75 cc (Group-1) and prostate volume less than 75 cc (Group-2), and these two groups were compared retrospectively. Patients who were followed up for 12 months were assessed. Results: There was no significant difference between the two groups in terms of age, preoperative PSA level, clinical stage distributions, Gleason score, D’Amico risk classification, preoperative potency and continence assessment (p>0.05). The operative time was 169.9 ± 62.5 minutes and 145.6 ± 56.1 minutes in Groups 1 and 2, respectively, and was significantly higher in Group 1 (p= 0.02). Bladder neck reconstruction was performed in 17 (35%) and 2 (3%) patients in Groups 1 and 2, respectively, and it was statistically significantly higher in Group-1 (p=0.001). After removal of the urethral catheter in Group 1 and Group 2, full continence and potency rates were similar during the 1-year follow-up (p >0.05). Biochemical recurrence rates at 6 months and 1 year were similar in Group 1 and Group 2 (p >0.05). Conclusion: In prostate cancer patients with large prostate volume, RARP results in longer operative time and bladder neck reconstruction may be required.. However, in operations performed by experienced surgeons, large prostate volume does not have a negative effect on surgical, functional and oncological outcomes. Keywords: robotic surgical procedures, prostatectomy, prostate, organ size","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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