Pub Date : 2023-10-25DOI: 10.33719/yud.2023-18-3-1344681
Yavuz BASTUG
Objective: COVID-19 pandemic continues to affect peoples’ lives throughout the world. It has been demonstrated that restrictions due to lifestyle changes affect peoples’ mental and sexual health. This study aimed to examine changes in male sexual behaviors and erectile status in early and late periods of lockdown and isolation during the COVID-19 pandemic. Material and Methods: A total of 206 volunteer males with active sexual lives were enrolled in the study. International Index of Erectile Function (IIEF-15) was adopted to assess sexual function and erection and Beck Depression Inventory (BDI) was adopted to assess mental status during the pandemic. Results: Erection, sexual desire, sexual intercourse and/or masturbation frequency and sexual pleasure increased significantly during the first month of the lockdown and isolation in Turkey, April 2020 (p<0.001), and it declined in May with the prolongation of the process (p<0.001). Levels of depression have increased significantly during the pandemic as well. Conclusion: This is the first study to examine male sexual behaviors and erection status separately in April and May, in the early period when lockdowns and isolation started due to the pandemic and in the late period with the prolongation of the process, however further research is needed.
{"title":"Effect of COVID-19 Pandemic on Male Sexual Behaviors and Erection Quality","authors":"Yavuz BASTUG","doi":"10.33719/yud.2023-18-3-1344681","DOIUrl":"https://doi.org/10.33719/yud.2023-18-3-1344681","url":null,"abstract":"Objective: COVID-19 pandemic continues to affect peoples’ lives throughout the world. It has been demonstrated that restrictions due to lifestyle changes affect peoples’ mental and sexual health. This study aimed to examine changes in male sexual behaviors and erectile status in early and late periods of lockdown and isolation during the COVID-19 pandemic. Material and Methods: A total of 206 volunteer males with active sexual lives were enrolled in the study. International Index of Erectile Function (IIEF-15) was adopted to assess sexual function and erection and Beck Depression Inventory (BDI) was adopted to assess mental status during the pandemic. Results: Erection, sexual desire, sexual intercourse and/or masturbation frequency and sexual pleasure increased significantly during the first month of the lockdown and isolation in Turkey, April 2020 (p<0.001), and it declined in May with the prolongation of the process (p<0.001). Levels of depression have increased significantly during the pandemic as well. Conclusion: This is the first study to examine male sexual behaviors and erection status separately in April and May, in the early period when lockdowns and isolation started due to the pandemic and in the late period with the prolongation of the process, however further research is needed.","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"150 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-27DOI: 10.33719/yud.2023;18-2-1247568
Gönül Özer, Sevinç Özmen
Objective: To compare physiological intracytoplasmic sperm injection (PICSI) and the hypoosmotic swelling test (HOST) sperm selection techniques in terms of embryo development, implantation rate and live birth rates in cases of severe or moderate oligoastheneospermia. Materials and Methods: The electronic material and files of cases admitted to the Medipol University IVF Centre between 2013 and 2022 were analyzed retrospectively. This research included a total of 143 cases with moderate or severe oligoasthenospermia, 80 cases with PICSI as sperm selection technique and 63 cases with HOST as sperm selection technique. Cases of severe or moderate oligoasthenospermia as defined by the World Health Organisation (WHO) are included in this study. The demographic parameters of both groups, including female age, paternal age, duration of infertility, AMH (anti-Mullerian hormone), body mass index (BMI), endometrial thickness, and the number of prior attempts, were analyzed. Implantation, pregnancy loss, and rates of live births were compared between two groups. Results: Female age, paternal age, AMH, endometrial thickness, BMI, and the number of previous trials were similar between the groups included in the study. There were not any significant differences between the groups in terms of fertilization (.18±6.92 vs 9.11±6.35, p=0.345), TQ-GQ blastocyst development (2.36±2.40 vs 1.64±2.35, p=0.097), and the number of embryos transferred (1.59±0.50 -1.76±0.44 p= 0.141). The live birth rates between the PICSI and HOST groups did not vary statistically (p=0.790), however, the rate of implantation was significantly higher in the HOST group (p=0.043). Sperm selection by PICSI or HOST method did not affect fertilization, TQ-GQ blastocyst development, and the rates of pregnancy loss and live birth. Conclusion: Although there were not any differences in embryo development, pregnancy loss, and live birth rates comparing the two methods, the HOST group had a higher implantation rate. Keywords: PICSI, HOST, Male infertlity, live birth
目的:比较生理胞浆内单精子注射(PICSI)和低渗肿胀试验(HOST)两种精子选择技术在重度和中度少精症患者胚胎发育、着床率和活产率方面的差异。材料与方法:回顾性分析2013年至2022年Medipol大学IVF中心收治病例的电子资料和档案。本研究共纳入143例中重度少弱精子症患者，PICSI选精技术80例，HOST选精技术63例。世界卫生组织(WHO)定义的重度或中度少弱精子症病例包括在本研究中。分析两组患者的人口学参数，包括女性年龄、父亲年龄、不孕持续时间、抗苗勒管激素(AMH)、体重指数(BMI)、子宫内膜厚度和既往尝试次数。比较两组之间的着床、妊娠丢失和活产率。结果:女性年龄、父亲年龄、AMH、子宫内膜厚度、BMI和先前试验的数量在研究中包括的组之间相似。各组受精率(0.18±6.92 vs 9.11±6.35,p=0.345)、TQ-GQ囊胚发育率(2.36±2.40 vs 1.64±2.35,p=0.097)、胚胎移植数(1.59±0.50 -1.76±0.44 p= 0.141)差异无统计学意义。PICSI组与HOST组的活产率差异无统计学意义(p=0.790)，但HOST组的着床率明显高于PICSI组(p=0.043)。PICSI或HOST法选择精子对受精、TQ-GQ囊胚发育、流产率和活产率均无影响。结论:虽然两种方法在胚胎发育、妊娠丢失和活产率方面没有差异，但HOST组的着床率更高。关键词:PICSI，宿主，男性不育，活产
{"title":"Comparison of the effects of sperm selection methods on assisted reproduction outcomes in male infertility","authors":"Gönül Özer, Sevinç Özmen","doi":"10.33719/yud.2023;18-2-1247568","DOIUrl":"https://doi.org/10.33719/yud.2023;18-2-1247568","url":null,"abstract":"Objective: To compare physiological intracytoplasmic sperm injection (PICSI) and the hypoosmotic swelling test (HOST) sperm selection techniques in terms of embryo development, implantation rate and live birth rates in cases of severe or moderate oligoastheneospermia. Materials and Methods: The electronic material and files of cases admitted to the Medipol University IVF Centre between 2013 and 2022 were analyzed retrospectively. This research included a total of 143 cases with moderate or severe oligoasthenospermia, 80 cases with PICSI as sperm selection technique and 63 cases with HOST as sperm selection technique. Cases of severe or moderate oligoasthenospermia as defined by the World Health Organisation (WHO) are included in this study. The demographic parameters of both groups, including female age, paternal age, duration of infertility, AMH (anti-Mullerian hormone), body mass index (BMI), endometrial thickness, and the number of prior attempts, were analyzed. Implantation, pregnancy loss, and rates of live births were compared between two groups. Results: Female age, paternal age, AMH, endometrial thickness, BMI, and the number of previous trials were similar between the groups included in the study. There were not any significant differences between the groups in terms of fertilization (.18±6.92 vs 9.11±6.35, p=0.345), TQ-GQ blastocyst development (2.36±2.40 vs 1.64±2.35, p=0.097), and the number of embryos transferred (1.59±0.50 -1.76±0.44 p= 0.141). The live birth rates between the PICSI and HOST groups did not vary statistically (p=0.790), however, the rate of implantation was significantly higher in the HOST group (p=0.043). Sperm selection by PICSI or HOST method did not affect fertilization, TQ-GQ blastocyst development, and the rates of pregnancy loss and live birth. Conclusion: Although there were not any differences in embryo development, pregnancy loss, and live birth rates comparing the two methods, the HOST group had a higher implantation rate. Keywords: PICSI, HOST, Male infertlity, live birth","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-27DOI: 10.33719/yud.2023;18-2-1210144
A. Erdik, H. Cimen, Y. Atik, D. Gül, Musa Pinar
Hematuria is defined as the presence of red blood cells in the urine and it may be observed microscopic or gross. Hematuria may originate from any site throughout the urinary tract, the glomerulus and interstitium or renal vasculature. Here, we present a 17-year-old boy who developed terminal hematuria after two months of treatment with isotretinoin for acne vulgaris. Radiological and cystoscopic assessment of the urinary system were normal. Isotretinoin treatment was stopped after dermatology consultation. In two weeks, terminal hematuria disappeared along with the dysuria, and the urine sample showed normal findings. Keywords: Acne vulgaris, adverse effect, gross hematuria, isotretinoin.
{"title":"Gross hematuria associated with oral isotretinoin treatment in a young patient with acne vulgaris","authors":"A. Erdik, H. Cimen, Y. Atik, D. Gül, Musa Pinar","doi":"10.33719/yud.2023;18-2-1210144","DOIUrl":"https://doi.org/10.33719/yud.2023;18-2-1210144","url":null,"abstract":"Hematuria is defined as the presence of red blood cells in the urine and it may be observed microscopic or gross. Hematuria may originate from any site throughout the urinary tract, the glomerulus and interstitium or renal vasculature. Here, we present a 17-year-old boy who developed terminal hematuria after two months of treatment with isotretinoin for acne vulgaris. Radiological and cystoscopic assessment of the urinary system were normal. Isotretinoin treatment was stopped after dermatology consultation. In two weeks, terminal hematuria disappeared along with the dysuria, and the urine sample showed normal findings. Keywords: Acne vulgaris, adverse effect, gross hematuria, isotretinoin.","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49002310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-27DOI: 10.33719/yud.2023;18-2-1196628
Serpil ABALI ÇETİN, Gürkan Karadağ
Objective: This study was carried out to determine whether the Turkish version of the Sexual Satisfaction Scale for Men (SSS-M), a modified version of the Women Sexual Satisfaction Scale (SSS-W) developed by Meston and his friends is a valid and reliable tool or not. Material and Methods: This is a methodological study and was conducted between March and July 2021. After the language translation and content validity studies of the 30-item of which Likert-type scale and five sub-dimensions a preliminary application was carried out on a group of 30 people. Data were obtained from 193 male individuals on an online platform after ethical approval. Whereas for the scopecontent validity of the scale Content Validity was used, to test for validity Confirmatory Factor Analysis was performed. To verify its dependableness, the Cronbach Alpha score and item-total correlation score were tested. The time invariance of the scale was evaluated with a test-retest. Results: The scale and content validity was reviewed by eight experts. The construct validity of the scale was performed by using confirmatory and exploratory factor analyses. Confirmatory factor loads were determined between .55 and .87, and exploratory factor loads were determined between 0.34 and .83. The correlation coefficient between the score of each item and the scale score was determined as r=.35-.80 (p<.001). The Cronbach Alpha internal consistency and reliability coefficients were found as .95 in the total of the scale and were found as.82-.95 in its sub-dimensions. No significant difference was found in the test-retest reliability analysis (p>.05). Conclusion: As a result of this study, it was determined that the Turkish version of the five-dimension "Sexual Satisfaction Scale for Men (SSS-M)" is a valid and reliable four-dimensional instrument and can be used in research and clinic. Keywords: sexual satisfaction, men, reability, validity
{"title":"The validity and reliability study of the Turkish version of the Sexual Satisfaction Scale for Men (SSS-M)","authors":"Serpil ABALI ÇETİN, Gürkan Karadağ","doi":"10.33719/yud.2023;18-2-1196628","DOIUrl":"https://doi.org/10.33719/yud.2023;18-2-1196628","url":null,"abstract":"Objective: This study was carried out to determine whether the Turkish version of the Sexual Satisfaction Scale for Men (SSS-M), a modified version of the Women Sexual Satisfaction Scale (SSS-W) developed by Meston and his friends is a valid and reliable tool or not. Material and Methods: This is a methodological study and was conducted between March and July 2021. After the language translation and content validity studies of the 30-item of which Likert-type scale and five sub-dimensions a preliminary application was carried out on a group of 30 people. Data were obtained from 193 male individuals on an online platform after ethical approval. Whereas for the scopecontent validity of the scale Content Validity was used, to test for validity Confirmatory Factor Analysis was performed. To verify its dependableness, the Cronbach Alpha score and item-total correlation score were tested. The time invariance of the scale was evaluated with a test-retest. Results: The scale and content validity was reviewed by eight experts. The construct validity of the scale was performed by using confirmatory and exploratory factor analyses. Confirmatory factor loads were determined between .55 and .87, and exploratory factor loads were determined between 0.34 and .83. The correlation coefficient between the score of each item and the scale score was determined as r=.35-.80 (p<.001). The Cronbach Alpha internal consistency and reliability coefficients were found as .95 in the total of the scale and were found as.82-.95 in its sub-dimensions. No significant difference was found in the test-retest reliability analysis (p>.05). Conclusion: As a result of this study, it was determined that the Turkish version of the five-dimension \"Sexual Satisfaction Scale for Men (SSS-M)\" is a valid and reliable four-dimensional instrument and can be used in research and clinic. Keywords: sexual satisfaction, men, reability, validity","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-27DOI: 10.33719/yud.2023;18-2-1193464
Hamide Ayben Korkmaz, Yılmaz Apaydın, İ. Ceylan
Objective: To investigate the effect of vasoactive drugs use in brain-dead organ donors in renal recipient graft function. Material and Methods: Clinical data from 30 brain-dead organ donors, and 30 recipients in our center were analyzed retrospectively between July 2017 and November 2021. Results: Norepinephrine infusion was used in all 30 cadaveric donors, where 11 donors had inotropic combinations. Norepinephrine was infused at a median dose of 0.2mcg/kg/min. There was no relationship between duration and doses of norepinephrine in donors and graft rejection, graft loss, and dialysis requirement in renal recipients. Conclusion: Intravenous norepinephrine infusion below 0.2mcg/kg/min had no effect on graft function in the renal recipient, where fluid restitution was sufficient in the cadaveric donor. Keywords: brain dead, organ donors, vasoactive drugs, graft survival
{"title":"Norepinephrine infusion in brain dead organ donor: A retrospective study on its effects on graft function after renal transplant","authors":"Hamide Ayben Korkmaz, Yılmaz Apaydın, İ. Ceylan","doi":"10.33719/yud.2023;18-2-1193464","DOIUrl":"https://doi.org/10.33719/yud.2023;18-2-1193464","url":null,"abstract":"Objective: To investigate the effect of vasoactive drugs use in brain-dead organ donors in renal recipient graft function. Material and Methods: Clinical data from 30 brain-dead organ donors, and 30 recipients in our center were analyzed retrospectively between July 2017 and November 2021. Results: Norepinephrine infusion was used in all 30 cadaveric donors, where 11 donors had inotropic combinations. Norepinephrine was infused at a median dose of 0.2mcg/kg/min. There was no relationship between duration and doses of norepinephrine in donors and graft rejection, graft loss, and dialysis requirement in renal recipients. Conclusion: Intravenous norepinephrine infusion below 0.2mcg/kg/min had no effect on graft function in the renal recipient, where fluid restitution was sufficient in the cadaveric donor. Keywords: brain dead, organ donors, vasoactive drugs, graft survival","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-27DOI: 10.33719/yud.2023;18-2-1220541
Prashant Sevach, G. Sharma, S. Priyadarshi
Objective: To discover the variables that may predict changes in blood pressure and blood sugar levels and to pinpoint the time frame during which such changes occur in patient with pheochromocytoma. Materials and Methodology: Consecutive patients undergoing surgery for pheochromocytoma over a 20-month period were included in this ethics review board-approved, prospective cohort study. Blood pressure and sugar levels were serially monitored using a fixed protocol in the perioperative period and subsequently at 3 months after surgery. Changes were compared and assessed for the predictive factors. Result: Fifty patients undergoing surgical procedures were included in the study of whom 32% developed hypotension and 10% developed hypoglycaemias after surgery. All hypotension episodes occurred within 6 hours of surgery. However, while 7 of 8 patients who developed hypoglycaemia manifest in the first 4 h after surgery, one occurred after 12 h. Occurrence of hypotension correlated with preoperative 24-h urinary vanillylmandelic acid levels (P = 0.024). Out of 21 hypertensive patients, 15 had persistent hypertension at 3 months and this was associated with age (P = 0.04) and diabetes mellitus at presentation. Conclusion: 32% of patients receiving pheochromocytoma surgery experienced postoperative hypotension needing inotropic support. Patients who require greater dosages of alpha-blockers or those with higher 24-h urine VMA levels are more prone to experience this. This happens within the first six hours following surgery. Patients who are older or who have had DM for a long time are more likely to suffer chronic HTN following surgery. Keywords: Pheochromocytoma, hypertension, hypoglycaemia, creatinine.
{"title":"Changes in blood pressure, blood sugar and creatinine in patients undergoing pheochromocytoma surgery","authors":"Prashant Sevach, G. Sharma, S. Priyadarshi","doi":"10.33719/yud.2023;18-2-1220541","DOIUrl":"https://doi.org/10.33719/yud.2023;18-2-1220541","url":null,"abstract":"Objective: To discover the variables that may predict changes in blood pressure and blood sugar levels and to pinpoint the time frame during which such changes occur in patient with pheochromocytoma. Materials and Methodology: Consecutive patients undergoing surgery for pheochromocytoma over a 20-month period were included in this ethics review board-approved, prospective cohort study. Blood pressure and sugar levels were serially monitored using a fixed protocol in the perioperative period and subsequently at 3 months after surgery. Changes were compared and assessed for the predictive factors. Result: Fifty patients undergoing surgical procedures were included in the study of whom 32% developed hypotension and 10% developed hypoglycaemias after surgery. All hypotension episodes occurred within 6 hours of surgery. However, while 7 of 8 patients who developed hypoglycaemia manifest in the first 4 h after surgery, one occurred after 12 h. Occurrence of hypotension correlated with preoperative 24-h urinary vanillylmandelic acid levels (P = 0.024). Out of 21 hypertensive patients, 15 had persistent hypertension at 3 months and this was associated with age (P = 0.04) and diabetes mellitus at presentation. Conclusion: 32% of patients receiving pheochromocytoma surgery experienced postoperative hypotension needing inotropic support. Patients who require greater dosages of alpha-blockers or those with higher 24-h urine VMA levels are more prone to experience this. This happens within the first six hours following surgery. Patients who are older or who have had DM for a long time are more likely to suffer chronic HTN following surgery. Keywords: Pheochromocytoma, hypertension, hypoglycaemia, creatinine.","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-27DOI: 10.33719/yud.2023;18-2-1187893
Rasim Güzel, L. Dragos, Ümit Yıldırım, B. Eryıldırım, K. Sarıca
Objective:: The objective of this study is to assess the efficacy of an herbal agent (Tutukon®) on the spontaneous passage rates of ureteral calculi 5-10 mm. Materials and Methods: 96 patients having a single radio-opaque ureteral stone 5-10 mm were randomized into two groups. Group 1 (n = 51) received Tutukon®, 45 mg/day (three times) in addition to conservative approach and Group 2 patients (n = 45) were followed with classical conservative approach during 4 weeks follow-up. The stone passage rates, stone expulsion time, change in weekly colic episodes and hospital readmission rates for colicky pain were compared. Results: Stone expulsion rates showed statistically significant difference between the two group (66.7 % vs 46.7 %, p = 0.048). Additionally mean time period required for the spontaneous passage of the calculi was meaningfully short in those cases receiving Tutukon® when compared with Group 2 patients undergoing conservative measures only (5.79 ± 2.39 vs 8.82 ± 3.48 days, respectively) (p = 0.001). Similarly, the mean renal colic episodes during follow-up period were significantly diminished in Group 1 patients (66.6 vs 36%, p = 0.001, respectively). Lastly, colic pain attacks were noted to be less in Group 1 and another advantage of“Tutukon®” was the relocation of the stones to a more distal part of ureter (35.2 vs 4 %). Conclusion: Use of Tutukon® in the medical management of ureteral calculi can accelarate the spontaneous passage rates and also relocate them into the lower portion of the ureter. Keywords: herbal agents, medical therapy, spontaneous passage, ureteral stones
目的:本研究的目的是评估中药制剂(Tutukon®)对输尿管结石5-10 mm自然通过率的影响。材料与方法:96例单发输尿管5 ~ 10 mm放射性不透明结石患者随机分为两组。组1 (n = 51)在保守入路的基础上给予Tutukon®45 mg/d(3次)治疗，组2 (n = 45)在4周的随访中继续采用经典保守入路治疗。比较结石通过率、结石排出时间、每周绞痛发作次数的变化以及因绞痛引起的再入院率。结果:两组结石排出率差异有统计学意义(66.7% vs 46.7%， p = 0.048)。此外，与仅接受保守治疗的2组患者相比，接受Tutukon®治疗的患者结石自然排出所需的平均时间明显缩短(分别为5.79±2.39天和8.82±3.48天)(p = 0.001)。同样，在随访期间，组1患者的平均肾绞痛发作次数显著减少(分别为66.6 vs 36%， p = 0.001)。最后，第1组绞痛发作较少，“Tutukon®”的另一个优势是将结石重新定位到输尿管较远的部分(35.2% vs 4%)。结论:Tutukon®在输尿管结石的医学治疗中可加快输尿管结石的自然通过速度，并使结石重新进入输尿管下段。关键词:中药，药物治疗，自然通过，输尿管结石
{"title":"The effect of an herbal agent “Tutukon®” on the spontaneous passage rates of ureteric stones","authors":"Rasim Güzel, L. Dragos, Ümit Yıldırım, B. Eryıldırım, K. Sarıca","doi":"10.33719/yud.2023;18-2-1187893","DOIUrl":"https://doi.org/10.33719/yud.2023;18-2-1187893","url":null,"abstract":"Objective:: The objective of this study is to assess the efficacy of an herbal agent (Tutukon®) on the spontaneous passage rates of ureteral calculi 5-10 mm. Materials and Methods: 96 patients having a single radio-opaque ureteral stone 5-10 mm were randomized into two groups. Group 1 (n = 51) received Tutukon®, 45 mg/day (three times) in addition to conservative approach and Group 2 patients (n = 45) were followed with classical conservative approach during 4 weeks follow-up. The stone passage rates, stone expulsion time, change in weekly colic episodes and hospital readmission rates for colicky pain were compared. Results: Stone expulsion rates showed statistically significant difference between the two group (66.7 % vs 46.7 %, p = 0.048). Additionally mean time period required for the spontaneous passage of the calculi was meaningfully short in those cases receiving Tutukon® when compared with Group 2 patients undergoing conservative measures only (5.79 ± 2.39 vs 8.82 ± 3.48 days, respectively) (p = 0.001). Similarly, the mean renal colic episodes during follow-up period were significantly diminished in Group 1 patients (66.6 vs 36%, p = 0.001, respectively). Lastly, colic pain attacks were noted to be less in Group 1 and another advantage of“Tutukon®” was the relocation of the stones to a more distal part of ureter (35.2 vs 4 %). Conclusion: Use of Tutukon® in the medical management of ureteral calculi can accelarate the spontaneous passage rates and also relocate them into the lower portion of the ureter. Keywords: herbal agents, medical therapy, spontaneous passage, ureteral stones","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47455175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-27DOI: 10.33719/yud.2023;18-2-1185919
N. Kalfazade, F. Akkaş, E. Şam, K. Seker, Ekrem Güner, S. Şahin, V. Tuğcu
Objective: This study aimed to investigate the safety and effectiveness of open simple prostatectomy (OSP) in patients older than 80 (i.e., octogenarians). Materials and Methods: Patients who underwent OSP in our center between January 2012 and January 2018 constituted this study's target population. The patients were evaluated by dividing the entire cohort into three age groups: 50-64, 65-79, and ≥80. The study groups were compared regarding demographic features, preoperative clinical data, operative parameters, postoperative first-month and third-month uroflowmetric data, and short-term complication rates. Results: Preoperative persistent acute urinary retention and urethral catheterization rates were significantly higher in octogenarians than in the other patients. The groups were similar concerning intraoperative estimated blood loss, blood transfusion, Clavien-Dindo Class≥3 complication rates and the general complication rate statistically. The comparative analysis revealed that the duration of catheterization was significantly longer in Group 2 and 3 than Group 1 (p=<0.001). The length of hospital stay was also significantly higher in octogenarians than the patients in Group 1 (p=0.003). Conclusion: Although OSP is an effective and safe surgical treatment method in octogenarians, each patient should be managed by an individualized approach for lowering the procedure-related morbidity and mortality rates. Keywords: Benign prostatic hyperplasia, Open simple prostatectomy, Octogenarians
{"title":"Safety and effectivity of open simple prostatectomy in octogenarians: A single center experience","authors":"N. Kalfazade, F. Akkaş, E. Şam, K. Seker, Ekrem Güner, S. Şahin, V. Tuğcu","doi":"10.33719/yud.2023;18-2-1185919","DOIUrl":"https://doi.org/10.33719/yud.2023;18-2-1185919","url":null,"abstract":"Objective: This study aimed to investigate the safety and effectiveness of open simple prostatectomy (OSP) in patients older than 80 (i.e., octogenarians). Materials and Methods: Patients who underwent OSP in our center between January 2012 and January 2018 constituted this study's target population. The patients were evaluated by dividing the entire cohort into three age groups: 50-64, 65-79, and ≥80. The study groups were compared regarding demographic features, preoperative clinical data, operative parameters, postoperative first-month and third-month uroflowmetric data, and short-term complication rates. Results: Preoperative persistent acute urinary retention and urethral catheterization rates were significantly higher in octogenarians than in the other patients. The groups were similar concerning intraoperative estimated blood loss, blood transfusion, Clavien-Dindo Class≥3 complication rates and the general complication rate statistically. The comparative analysis revealed that the duration of catheterization was significantly longer in Group 2 and 3 than Group 1 (p=<0.001). The length of hospital stay was also significantly higher in octogenarians than the patients in Group 1 (p=0.003). Conclusion: Although OSP is an effective and safe surgical treatment method in octogenarians, each patient should be managed by an individualized approach for lowering the procedure-related morbidity and mortality rates. Keywords: Benign prostatic hyperplasia, Open simple prostatectomy, Octogenarians","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-27DOI: 10.33719/yud.2023;18-2-1270777
İ. Ozdemi̇r, F. Çalışkan, Y. O. Danacıoğlu
Objective: The attitudes and knowledge level of individuals toward prostate cancer screening are important factors affecting participation in screening. This study aimed to determine the relationship between prostate cancer screening attitudes, beliefs, and knowledge levels of men working in a tertiary healthcare institution. Material and Methods: A total of 236 healthcare personnel working in a tertiary education and research hospital were included in the study. In the collection of data, an information form, the Health Beliefs Model Scale for Prostate Cancer Screenings (HBM-PCS), and the Knowledge About Prostate Cancer Screening Questionnaire (KPCSQ) were used. Results: The mean age of the men participating in the study was 46.7±5.9 years. Of the participants, 16.1% had previously undergone a prostate-specific antigen test, and 67.4% had a low level of knowledge. When the subscales of HBM-PCS were examined, the participants had a mean score of 12.6±3.8 on susceptibility perception, 11.9±3.6 on seriousness perception, 32.9±7.6 on health motivation perception, 38.5±10.3 on barrier perception, and 24.8±5.7 on benefit perception. There was no significant difference in the participants’ HBM-PCS scores according to their KPCSQ scores. Conclusion: It was determined that the men participating in this study had a low level of knowledge, moderate levels of susceptibility, seriousness, and barrier perceptions, and high levels of health motivation and benefit perceptions concerning prostate cancer screening. It is important to raise the awareness of healthcare workers about the benefits of screening and early diagnosis of prostate cancer through training programs. Keywords: prostate cancer, screening, attitude, belief, knowledge level
{"title":"Relationship between the prostate cancer screening attitudes, beliefs, and knowledge levels of men working in a healthcare institution","authors":"İ. Ozdemi̇r, F. Çalışkan, Y. O. Danacıoğlu","doi":"10.33719/yud.2023;18-2-1270777","DOIUrl":"https://doi.org/10.33719/yud.2023;18-2-1270777","url":null,"abstract":"Objective: The attitudes and knowledge level of individuals toward prostate cancer screening are important factors affecting participation in screening. This study aimed to determine the relationship between prostate cancer screening attitudes, beliefs, and knowledge levels of men working in a tertiary healthcare institution. Material and Methods: A total of 236 healthcare personnel working in a tertiary education and research hospital were included in the study. In the collection of data, an information form, the Health Beliefs Model Scale for Prostate Cancer Screenings (HBM-PCS), and the Knowledge About Prostate Cancer Screening Questionnaire (KPCSQ) were used. Results: The mean age of the men participating in the study was 46.7±5.9 years. Of the participants, 16.1% had previously undergone a prostate-specific antigen test, and 67.4% had a low level of knowledge. When the subscales of HBM-PCS were examined, the participants had a mean score of 12.6±3.8 on susceptibility perception, 11.9±3.6 on seriousness perception, 32.9±7.6 on health motivation perception, 38.5±10.3 on barrier perception, and 24.8±5.7 on benefit perception. There was no significant difference in the participants’ HBM-PCS scores according to their KPCSQ scores. Conclusion: It was determined that the men participating in this study had a low level of knowledge, moderate levels of susceptibility, seriousness, and barrier perceptions, and high levels of health motivation and benefit perceptions concerning prostate cancer screening. It is important to raise the awareness of healthcare workers about the benefits of screening and early diagnosis of prostate cancer through training programs. Keywords: prostate cancer, screening, attitude, belief, knowledge level","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-27DOI: 10.33719/yud.2023;18-2-1150164
M. Ezer, Fatma YILMAZ ERTÜRK, Hatice Beşeren, Y. Adalı
Objective: Cyclin D1 is a protein that is involved in the regulation of the cell cycle and is encoded by the CCND1 gene. There are few studies on Cyclin D1 in the literature, and the results differ in the studies. In this study, the relationship between Cyclin D1 Expression and prognostic factors in bladder urothelial carcinomas was investigated. Materials and Methods: Forty-six patients who underwent TUR-M at the Kafkas University Health Research and Application Hospital were included in the study. General information about the cases and pathology reports were obtained from the hospital automation system. Tumor-containing sections were selected from the ready-stained pathology preparations, and immunohistochemical staining was performed manually with Cyclin D1 primary antibody on the blocks of the selected sections, as indicated below. Stained sections were evaluated under the light microscope by scoring 0-4 separately as nuclear and cytoplasmic. Results: The age range of the cases was 51-93, and the mean age was 69.2±11.7. Twelve (26.1%) cases were female and 34 (73.9%) were male. When the histopathological findings were examined, it was observed that 29 (63.0%) of the cases were low-grade and 17 (37.0%) were high-grade. Eighteen (39.1%) of the cases were invasive and 28 (60.9%) were noninvasive. In the statistical analyzes performed, it was noted that invasive tumors had a statistically significantly higher grade compared to non-invasive tumors (pTa) (p= 0.007). Similarly, the presence of lymphovascular invasion in invasive tumors was statistically significantly higher than in non-invasive tumors (p=0.001). It was observed that nuclear cyclin D1 expression (p=0.003) was statistically significantly higher in invasive cases. In addition, nuclear cyclinD1 expression was found to be statistically significantly higher in low-grade tumors (p=0.044). Conclusion: As a result of the study, a relationship between Cyclin D1 expression and tumor grade and invasion status was observed in patients with bladder urethelial carcinoma, but studies with larger case series are needed to use Cyclin D1 as a biomarker. Keywords: bladder, Cyclin D1, urothelial carcinoma, immunohistochemistry
{"title":"Investigation of Cyclin-D1 immunohistochemical expression in bladder urethelial carcinoma","authors":"M. Ezer, Fatma YILMAZ ERTÜRK, Hatice Beşeren, Y. Adalı","doi":"10.33719/yud.2023;18-2-1150164","DOIUrl":"https://doi.org/10.33719/yud.2023;18-2-1150164","url":null,"abstract":"Objective: Cyclin D1 is a protein that is involved in the regulation of the cell cycle and is encoded by the CCND1 gene. There are few studies on Cyclin D1 in the literature, and the results differ in the studies. In this study, the relationship between Cyclin D1 Expression and prognostic factors in bladder urothelial carcinomas was investigated. Materials and Methods: Forty-six patients who underwent TUR-M at the Kafkas University Health Research and Application Hospital were included in the study. General information about the cases and pathology reports were obtained from the hospital automation system. Tumor-containing sections were selected from the ready-stained pathology preparations, and immunohistochemical staining was performed manually with Cyclin D1 primary antibody on the blocks of the selected sections, as indicated below. Stained sections were evaluated under the light microscope by scoring 0-4 separately as nuclear and cytoplasmic. Results: The age range of the cases was 51-93, and the mean age was 69.2±11.7. Twelve (26.1%) cases were female and 34 (73.9%) were male. When the histopathological findings were examined, it was observed that 29 (63.0%) of the cases were low-grade and 17 (37.0%) were high-grade. Eighteen (39.1%) of the cases were invasive and 28 (60.9%) were noninvasive. In the statistical analyzes performed, it was noted that invasive tumors had a statistically significantly higher grade compared to non-invasive tumors (pTa) (p= 0.007). Similarly, the presence of lymphovascular invasion in invasive tumors was statistically significantly higher than in non-invasive tumors (p=0.001). It was observed that nuclear cyclin D1 expression (p=0.003) was statistically significantly higher in invasive cases. In addition, nuclear cyclinD1 expression was found to be statistically significantly higher in low-grade tumors (p=0.044). Conclusion: As a result of the study, a relationship between Cyclin D1 expression and tumor grade and invasion status was observed in patients with bladder urethelial carcinoma, but studies with larger case series are needed to use Cyclin D1 as a biomarker. Keywords: bladder, Cyclin D1, urothelial carcinoma, immunohistochemistry","PeriodicalId":33828,"journal":{"name":"Yeni Uroloji Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69671588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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