Addiction and Health最新文献

Background: Many waterpipe users are willing to quit but have difficulty doing so. Little is known about the characteristics of those who are willing to quit.

Methods: Using two-stage cluster sampling, we conducted a secondary analysis of a population-based household survey of 2038 adults in Aleppo, Syria. We examined the prevalence of, and reasons for, willingness to quit and compared users who were willing with those were not willing to quit based on sociodemographic, psychosocial, tobacco-related, and health-related characteristics.

Findings: Twelve percent of adults smoked waterpipe (n=248), of these, 56% were willing to quit, and 25% had made a quit attempt in the past year. Friends/socializing (69%) and boredom/free time (16%) were the most reported obstacles to quitting. Those who were willing to quit walked more frequently (odds ratio [OR]=1.85; 95% confidence interval [CI]=1.24-2.77), ate less fruit (OR=0.56; CI=0.42-0.73), and were more likely to experience sneezing/blocked nose (OR=2.55, CI=1.22-5.34). Compared to users who did not also smoke cigarettes, dual users who were willing to quit cigarettes were more likely to be willing to quit waterpipe (OR=2.32; CI=1.24-4.34), whereas dual users who were not willing to quit cigarettes were less likely to be willing to quit waterpipe (OR=0.24; CI=0.10-0.58).

Conclusion: Many waterpipe users are willing to quit and perceive the loss of positive social functions as a major obstacle. Very few sociodemographic, tobacco-related, psychosocial, or health-related characteristics are associated with willingness to quit. However, quitting efforts may benefit from targeting dual users who are motivated to quit using all tobacco products.

Background: Mobile phones have become a vital part of modern life, generating concerns about addiction among students. The present study aimed to assess smartphone usage and addiction among undergraduate dental students in Eluru, Andhra Pradesh.

Methods: A cross-sectional study was conducted among 304 dental students using a pre-designed questionnaire based on the Smartphone Addiction Scale Short Version (SAS-SV). Data was analyzed using descriptive and inferential statistics.

Findings: Out of 304 participants, most spent 3-4 hours on smartphones. Females showed slightly lower addiction scores than males. Addiction tendencies differed across different academic years, with second-year students scoring the highest.

Conclusion: The study's findings suggested that most dental students were addicted to smartphones. The study also revealed that having a smartphone was a crucial asset in their daily lives, and they preferred smartphones with advanced features.

Background: Tramadol, one of the most common opioid pain relievers, acts upon the µ-receptor in the central nervous system (CNS) to alleviate pain associated with various situations like postoperative pain, arthritis, and muscular pain. Additionally, it has been utilized to address depression and anxiety disorders. Extensive research has shown that tramadol can potentially inflict irreversible harm on different regions of the CNS, including the cerebrum, cerebellum, amygdala, and, notably, the hippocampal formation. However, the precise mechanism behind these effects remains unclear. Within this study, we conducted a comprehensive examination of the impacts of tramadol on the CNS, specifically focusing on hippocampal formation.

Methods: In this study, we collected relevant articles published between 2000 and 2022 by conducting searches using specific keywords, including tramadol, tramadol hydrochloride, central nervous system, hippocampus, and hippocampal formation, in various databases.

Findings: The results of this study proposed several processes by which tramadol may impact the CNS, including the induction of apoptosis, autophagy, excessive production of free radicals, and dysfunction of cellular organelles. These processes ultimately lead to disturbances in neural cell function, particularly within the hippocampus. Furthermore, it is revealed that tramadol administration led to a significant decrease in the neural cell count and the volume of various regions within the brain and spinal cord.

Conclusion: Consequently, neuropsychological impairments, such as memory formation, attention deficits, and cognitive impairment, may happen. This finding highlights the potential impacts of tramadol on neural structures and warrants further investigation.

Background: Nicotine dependence is one of the most significant barriers to smoking cessation. Therefore, measuring this dependence is crucial for effective smoking cessation interventions. The current study aimed to evaluate the degree of agreement between the Fagerström Test for Nicotine Dependence (FTND) and the Heaviness of Smoking Index (HSI) among Iranian smokers.

Methods: We analyzed the data obtained from two previous studies among 580 daily smokers in Iran. Data were collected using the FTND scale. Cohen's kappa was utilized to assess the degree of agreement between HSI and FTND.

Findings: The HSI showed significant agreement with FTND (Cohen's kappa=0.72) in assessing nicotine dependence, with a sensitivity of 88.6% and a specificity of 90.3%.

Conclusion: The HSI is a valid and reliable tool for measuring nicotine dependence, exhibiting significant agreement with FTND. As a result, the HSI can be considered an alternative to the FTND in both clinical and research settings, particularly for heavy smokers.

Background: The primary objective of the current paper was to assess the psychometric attributes of the Persian version of the Online Gambling Symptom Assessment Scale (P-OGSAS) within the Iranian population.

Methods: The current study was conducted through a convenient sampling method between September and November 2021, involving 187 participants who had experienced online gambling at least once a month for the last 3 months. OGSAS was translated from English into Persian using the forward-backward translation method. Cronbach's alpha coefficient and principal component analysis (PCA) were employed to evaluate the reliability and validity of the scale, respectively. Participants were administered a battery of assessments, including P-OGSAS, Persian Gambling Disorder Screening Questionnaire (GDSQ-P), Patient Health Questionnaire-9 Items (PHQ-9), and Generalized Anxiety Disorder Questionnaire (GADQ-7), to assess validity and reliability.

Findings: The results showed that the 3-factor model of this scale provides the highest level of predictability. The 3-factor model accounts for 54.8% of the square load. With a Cronbach's alpha coefficient of 0.807, P-OGSAS demonstrated satisfactory reliability. Finally, OGSAS has a significant correlation with other scales, and as a result, this scale has suitable convergent validity.

Conclusion: P-OGSAS can adequately assess the symptoms and severity of online gambling. Therefore, clinicians could use this scale to evaluate the problems related to online gambling in the Iranian population.

Background: Hitherto, no instrumental research has been designed to measure the addiction potential for children in Iran. Therefore, the questionnaires designed to investigate addiction were examined in this systematic review article.

Methods: In the present systematic review, all Iranian and foreign research on addiction potential for children were examined until March 2022. Using separate keywords and their Latin synonyms according to Mesh terms, an extensive search was conducted in databases: PubMed, Magiran, Iranmedex, Medline, Google Scholar, SID, and Irandoc. In total, 173 Farsi and English papers were included in the initial list, and after evaluation according to the Meta-analysis of Observational Studies in Epidemiology (MOOSE) checklist and acceptance criteria, 43 final papers were selected for systematic review.

Findings: Through searching in Persian and English databases and using related keywords, 173 papers were found in the initial search and after removing duplicates and unrelated studies, 43 papers were selected for systematic review. In this research, papers related to the addiction potential between 1998 and 2019 were considered, and among these, 22 papers particularly dealt with addiction. In the conducted studies, the awareness, attitude, talent, and factors affecting addiction were mostly measured and in some papers, addiction potential was measured.

Conclusion: Designing psychometrically appropriate tools is necessary to measure the addiction potential of children in Iran. Due to the unavailability of appropriate tools and the fact that the previous versions are not up to date and are not checked regularly, for better and more complete decision-making in the health policy-making process more investigation in this field is necessary.

Background: The harmful effects of drug relapse have always been one of the major challenges in addiction treatment. The present study aimed to predict drug relapse in addicted men under treatment based on experiential avoidance, integrative self-knowledge, and basic psychological needs.

Methods: The present study was a correlational one. The statistical population included all addicted men in Choubindar prison in Qazvin in 2021, among whom 200 individuals were selected randomly. Then, the participants filled out the Relapse Prediction Scale (RPS), Multidimensional Experiential Avoidance Questionnaire (MEAQ), Integrative Self-Knowledge Scale (ISK), and Basic Psychological Needs Scale (BPNS). Data were analyzed using stepwise regression via SPSS software (version 25).

Findings: The results of the study demonstrated that some of the components of experiential avoidance including distraction, distress endurance, behavioral avoidance, and distress aversion could account for 14.0% of the variance of the relapse in the addicts (P<0.05). Moreover, the obtained results considering the reflective self-knowledge component and the overall score of integrative self-knowledge could explain 15.0% of the variance in relapse in the addicts. Among the basic psychological needs, communication could predict 3.8% of the variance in relapse.

Conclusion: Based on the results of the present study, it is suggested that through addiction treatment and prevention of relapse programs, psychologists reduce drug relapse in addicts by decreasing distractions and behavioral avoidance, increasing distress endurance, enhancing self-knowledge, and improving efficient relationships.

Background: While personality predominantly influences human cognition, emotion, and behavior, there is still an unresolved research gap concerning the association between personality and substance use within the Sri Lankan context.

Methods: This descriptive cross-sectional study aimed to investigate the association between personality traits and substance use among advanced-level students aged over 18 in Western province, Sri Lanka, in 2023. Data collection was carried out using self-administered paper-pencil questionnaires. The study variables were measured using the brief version of the Big Five Personality Inventory and the Alcohol, Smoking, and Substance Involvement Questionnaire. Data analysis involved the use of the chi-square test and Spearman correlation.

Findings: Of the 441 enrolled participants, 422 provided correct responses to the questionnaire. Among them, 154 (36.5%) reported substance use. The majority of students initiated substance use at the age of 17. The results reveal a significant association between the openness personality trait and substance use among advanced-level students in Western province. Additionally, there was a statistically significant positive correlation between the extroversion personality trait and amphetamine use among advanced-level students.

Conclusion: The findings highlight a significant association between specific personality traits, particularly openness and extroversion, and substance use among advanced-level students in Western province, Sri Lanka. These results emphasize the significance of considering personality factors in understanding and addressing substance use behaviors among youth populations. Further research and targeted interventions are necessary to delve deeper into these associations and develop effective prevention and intervention strategies.

The orexinergic system and its receptors are involved in many physiological processes. Their functions in energy homeostasis, arousal, cognition, stress processing, endocrine functions, and pain modulation have been investigated. Many studies have shown that the orexinergic system cooperates with the dopaminergic system in the addiction process. Emerging evidence suggests that the orexinergic system can be effective in the induction of drug dependence and tolerance. Therefore, several researches have been conducted on the effect of orexin receptor (OXR) antagonists on reducing tolerance and dependence caused by drug abuse. Due to the significant growth of the studies on the orexinergic system, the current literature was conducted to collect the findings of previous studies on orexin and its receptors in the induction of drug addiction. In addition, cellular and molecular mechanisms of the possible role of orexin in drug tolerance and dependence are discussed. The findings indicate that the administration of OXR antagonists reduces drug dependence. OXR blockers seem to counteract the addictive effects of drugs through multiple mechanisms, such as preventing neuronal adaptation. This review proposes the potential clinical use of OXR antagonists in the treatment of drug dependence.

Background: Varenicline tartrate is a new and selective agonist of the nicotinic acetylcholine receptor (nAChR). This systematic review and meta-analysis aimed to determine varenicline efficacy in smoking cessation among hospitalized patients.

Methods: We looked through worldwide databases such as Web of Science, Embase, PubMed, Cochrane, and Scopus. Relevant pieces of research published on varenicline efficacy on smoking cessation among hospitalized patients were discovered using proper keywords. The data were analyzed using Stata software version 14 and a random-effects model meta-analysis.

Findings: Nine studies were eligible to be included in this study, with a total sample size of 2131. Generally, the point abstinence rate was significantly greater in the varenicline group than in the placebo group at weeks 12 (odds ratio [OR]=0.59; 95% CI: 053-0.65; P<0.001), 24 (OR=0.78; 95% CI: 0.72-0.84; P<0.001), and 52 (OR=0.86; 95% CI: 0.80-0.92; P<0.001). Furthermore, the continuous abstinence rate for weeks 4 (OR=0.70; 95% CI: 019-0.54; P=0.000), 12 (OR=0.26; 95% CI: 019-0.54; P<0.001), 24 (OR=0.32; 95% CI: 019-0.53; P<0.001), and 52 (OR=0.32; 95% CI: 019-0.54; P<0.001) was significantly greater in the varenicline group than in the placebo group.

Conclusion: According to the high efficacy of varenicline in both short- and long-term smoking settings and considering the importance of smoking cessation in high-risk hospitalized patients, varenicline consumption could be considered as a main smoking cessation strategy in these patients.