Addiction and Health最新文献

Background: High blood lead levels (BLLs) in pregnant women are associated with poor outcome in neonates. One of the newest non-occupational sources of lead contamination is opium consumption. Accordingly, this study aimed to assess BLLs in mothers addicted to opium and their neonates in Kerman.

Methods: This cross-sectional was conducted in Afzalipour hospital in Kerman, from February 2019 to February 2020. The BLLs were measured in 100 opium-addicted and non-addicted mothers and their newborns, and the lead levels higher than 5 μg/dL were considered contamination. Then, the demographic and anthropometric data were compared.

Findings: Based on the results of the present study, the BLLs of opium-addicted mothers (33.40±9.22 μg/dL vs 3.2±1.5 μg/dL) and their neonates (13.46±4.86 vs 1.1±0.9) were significantly higher (P=0.001) than those of non-addicts. Moreover, the average birth weight of the newborns in the addicted group was significantly lower than in the non-addicted group (2572.8±77.49 vs 2946±46.87) (P=0.001). Besides, there was a significant relationship between the average birth weight and the BLL of the mother and baby, and the average weight of the babies was significantly lower at higher levels of lead. However, no correlation was observed regarding the average height and head circumference of the neonates (P>0.05).

Conclusion: It seems that the serum level of lead in neonates of opium-addicted mothers contaminated with lead is significantly higher than that of non-addicts, but their anthropometric characteristics at birth were not different from those of the nonaddicted group.

Background: Despite the legal acceptance of homosexuality in India, it remains a social taboo, resulting in various challenges being faced by homosexual males. These challenges mainly include issues such as addiction/drug use and inconsistent and/ or incorrect condom usage which increase the risk of acquiring sexually transmitted infections (STIs) and HIV among them. This study was thus conducted with the objective of studying the patterns of addiction/drug use and condom usage among homosexual males.

Methods: The study was conducted at outreach sites of a non-governmental organization (NGO). A total of 240 participants, consisting of homosexual and bisexual males aged 18-24 years who were residing in the metropolitan city of Mumbai for at least 1 year, were enrolled. Data about addiction/drug use and patterns of condom usage was collected, compiled, entered into Microsoft Excel, and subsequently analyzed using SPSS.

Findings: Out of the total participants, 171 (71.2%) reported engaging in addiction/drug use, Among those participants, 105 (61.4%) engaged in alcohol consumption prior to sexual contact to enhance pleasure or delay climax. Cigarette smoking was the most common type of addiction. Statistically significant association was found between habitual addiction/drug use (P=0.0023), use of ecstasy/aphrodisiac drugs (P=0.00654) and, inconsistent and/or incorrect condom use among the participants. However, planned addiction/drug use only before sexual contact did not show a significant association (P=0.066).

Conclusion: Habitual addiction/drug use among homosexual males increases the likelihood of engaging in inconsistent and/ or incorrect condom use, thereby elevating the risk of acquiring STIs and HIV. To mitigate this risk, interventions targeting addiction/ drug use prevention should be initiated during adolescence to address this issue at an earlier stage of life.

Background: Substance use disorder (SUD) remains a significant public health issue, with a high relapse rate even after detoxification treatment. Family dysfunction has been identified as a closely related factor contributing to relapse in individuals with SUD. The objective of this study was to investigate the mediating role of family climate in the relapse tendency among patients with SUD.

Methods: The study employed a case-control design using the survey method. A total of 103 patients from the addiction unit daycare at Mansoura University Hospital were divided into 2 groups: the relapsed group and the abstinent group. The Relapse Tendency Questionnaire, the Family Climate Scale, and a structured interview were administered to collect sociodemographic data.

Findings: The results revealed significant differences between the study groups in terms of sociodemographic risk factors, including marital status (P≤0.001), employment (P=0.043), and economic status (P=0.028). Additionally, a significant difference was observed between the study groups in terms of the Family Climate Scale (P=0.038). Female participants reported that familial factors had a greater influence on their relapse compared to male participants (P=0.005).

Conclusion: A statistically significant difference was found in the family climate subscale scores between the relapsed patients and the abstinent patients with SUD, confirming the influential role of family climate in the relapse process of SUD.

Background: Internet gaming has become popular in the last few decades; however, very few studies have been conducted on internet gaming in India. This study aimed to investigate internet gaming disorder (IGD), its prevalence, gaming behavior, and effects as well as multiple factors associated with its emergence among college students.

Methods: This cross-sectional study involved a group of 150 college students. Data were collected using a semi-structured questionnaire containing the Internet Gaming Disorder Scale-Short Form (IGDS9-SF). Statistical analysis was done using Jamovi software.

Findings: A total of 150 college student gamers were involved with a mean age of 18.69±0.10 years. The mean IGD score was 18.74 with a standard deviation of 0.53, while the median score was 18. The prevalence of IGD was 5.3% among the participants. The IGD prevalence was higher in male students and those whose mothers had a high school diploma or higher. Gamers who spent more than2 hours a day on games had significantly higher IGD scores (P<0.05). A significant association was also found between tingling/numbness in the hand while playing and physical pain with IGD (P<0.05).

Conclusion: Spending more time playing online games was significantly associated with a higher risk of IGD. One negative consequence of IGD is the development of physical health issues. It is important to raise awareness about the physical health consequences of excessive gaming among students, parents, institutions, and concerned authorities.

Background: The risk of substance use is increasing among university students, especially medical students. This study aimed to investigate the frequency of smoking, alcohol consumption, and substance use and its relationship with general health indicators among the students of Guilan University of Medical Sciences (GUMS) in 2020. The differences in the frequency of substance use were also investigated from 2005.

Methods: This was a cross-sectional analytical study conducted on 406 students of GUMS, Iran, in 2020. The data were collected through three online questionnaires including a demographic questionnaire, the Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST), and the General Health Questionnaire (GHQ). The data were entered into SPSS software version 22 and analyzed using Chi-square, Fisher's Exact tests, and logistic regression at a significance level of 0.05.

Findings: In this study, 53.9% of the participants were female, 46.1% were male, and 54.4% of them experienced using substances in their lifetime. The highest prevalence of use was in consumers of tobacco (46.8%), alcoholic beverages (34.7%), and cannabinoid compounds (19%). Besides, 48.5% of the participants were suspected of having some degree of psychiatric disorders, among which depression (11.6%) and anxiety (8.4%) were the most common. Moreover, substance use during students' lifetime had a statistically significant association with anxiety, depression, and mental health.

Conclusion: The results of this study showed the prevalence of smoking, alcohol consumption, and substance use among the students of GUMS is worrying. The relationship between consumption and consumer's health indicators highlights the necessity of intervention and purposeful planning by policymakers in this field.

Background: This study aimed to assess the association of sleep apnea syndrome (SAS) with methadone dose and timing of administration in patients receiving methadone maintenance treatment (MMT) for opioid use disorder (OUD).

Methods: This retrospective cross-sectional study was conducted on adult patients receiving MMT who had a nocturnal respiratory polygraphy between November 2015 and December 2021. Data on methadone treatment and polygraph recording, including the apnea-hypopnea index (AHI) were collected.

Findings: A total of 40 patients, mostly male (72.5%), with a mean age of 35±6.7 years and a mean body mass index (BMI) of 25.1±4.5 kg/m² were included. The daily dose of methadone was significantly associated with an AHI≥15 events/h as well as an AHI≥30 events/h, even after adjustment for age, gender, BMI, and benzodiazepine use. However, these associations were not preserved when the time of administration (day vs evening) was considered, while the evening administration was significantly associated with an AHI≥15 events/h. The best sensitivity and specificity for the prediction of AHI≥15 events/h and AHI≥30 events/h were obtained with daily methadone doses of≥72.5 mg and 77.5 mg, respectively.

Conclusion: In this sample of MMT patients, methadone doses of 72.5 mg and 77.5 mg were the best cut-off values for predicting AHI≥15 and≥30 events/h, respectively, especially when taken in the evening. These results should draw clinicians' attention to the importance of SAS screening, and further studies are needed, notably comparisons with buprenorphine.

Background: Smoking is more common in patients with schizophrenia than in healthy populations. Some controversial hypotheses connect the disease with the high prevalence of smoking. Moreover, environmental factors affect the severity of the positive and negative symptoms of schizophrenia. The current study aimed to assess the effect of enriched environment (EE) and nicotine on the MK-801 animal model of schizophrenia.

Methods: Male Wistar rat pups randomly received saline or MK-801 (dose:1 mg/kg) for five days from the sixth postnatal day (P) until the tenth. The pups were placed in EE or standard cages (SCs) after weaning (P21). Morris water maze (MWM) was used to assess spatial learning and memory. The rats received 0.6 mg/kg nicotine twice for three days at the end of the second month and were examined in an open-field box and three-chamber social interaction test.

Findings: MK-801 rats' behaviors were the same as those of the saline rats when they were exposed to nicotine. No positive effects of EE were observed when the animals were exposed to nicotine.

Conclusion: The results suggested that nicotine decreased schizophrenia-like symptoms and covered the positive effects of EE.

Background: The adverse effects of addiction relapse have always been major challenges in addiction treatment. Perceived social support and childhood trauma are determinants of drug addiction and relapse prevention. The current study aimed to predict drug addiction relapse based on perceived social support and childhood trauma in drug addiction treatment centers in Qom, Iran.

Methods: The present study examined 320 individuals, who visited drug addiction treatment centers in Qom, Iran and were selected using the purposive sampling method. The data collection tools included a demographic information questionnaire, the Social Support Scale, the Childhood Trauma Questionnaire-Short Form (CTQ-SF), and the Addiction Relapse Frequency Questionnaire. Data were analyzed using SPSS 20 and independent t-tests, analysis of variance (ANOVA), Pearson test, and multivariate regression.

Findings: The research results indicated that 49.4% (n=158) of cases used opium. The results of multivariate regression of the factors related to addiction relapse indicated that the childhood trauma score had a significant effect on the relapse of more than 3 times in a way that childhood trauma increased the relapse rate of more than 3 times by 13%, but social support caused a significant reduction in the relapse rate of more than 3 times.

Conclusion: The research findings indicated that addiction relapse had a significant relationship with childhood trauma and perceived social support. The results can be a guide for future studies to expand psychological knowledge about the determinants of the treatment and prevention of addiction relapse and help to develop psychological explanations of this disorder.

Background: Eating disorders have become increasingly prevalent over the years; the age at which they appear has decreased, and they can lead to serious illness or death. Therefore, the number of studies on the matter has increased. Eating disorders like anorexia nervosa (AN) and bulimia nervosa (BN) are affected by many factors including mental illnesses that can have serious physical and psychological consequences. Accordingly, the present study aimed to compare the clinical and metabolic features of patients with AN and BN and identify potential biomarkers for distinguishing between the two disorders.

Methods: Clinical data of 41 participants who sought treatment for eating disorders between 2012 and 2022, including 29 AN patients and 12 BN patients, were obtained from NPIstanbul Brain Hospital in Istanbul, Turkey. The study included the clinical variables of both outpatient and inpatient treatments. Principal component analysis (PCA) was utilized to gain insights into differentiating AN and BN patients based on clinical characteristics, while machine learning techniques were applied to identify eating disorders.

Findings: The study found that thyroid hormone levels in patients with AN and BN were influenced by non-thyroidal illness syndrome (NTIS), which could be attributed to various factors, including psychiatric disorders, substance abuse, and medication use. Lipid profile comparisons revealed higher triglyceride levels in the BN group (P<0.05), indicating increased triglyceride synthesis and storage as an energy source. Liver function tests showed lower levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in BN patients (P<0.05), while higher prolactin levels (P<0.05) suggested an altered hypothalamic-pituitary-gonadal axis. Imbalances in minerals such as calcium and magnesium (P<0.05) were observed in individuals with eating disorders. PCA effectively differentiated AN and BN patients based on clinical features, and the Naïve Bayes (NB) model showed promising results in identifying eating disorders.

Conclusion: The findings of the study provide important insights into AN and BN patients' clinical features and may help guide future research and treatment strategies for these conditions.