首页 > 最新文献

B''lgarska kardiologiia最新文献

英文 中文
Distal transradial access. Initial experience. Results 远端经桡动脉入路。初步经验。后果
Pub Date : 2022-09-30 DOI: 10.3897/bgcardio.28.e79042
M. Mihalev
Introduction: Conventional access through the radial artery (cTRA) is a standard approach in coronary interventions. Unfortunately, it carries a risk of long-term complications such as radial artery occlusion (RAO) and local complications, usually hematomas. Aim: Sharing initial experience in the application of distal transradial access (dTRA) on 134 patients, from single operator in one center and its applicability on patients with STEMI. Number of procedures required to get experience with this access, assessed by the degree of reduction of failed procedures. Materials and methods: From 08.03.21 to 18.11.21, 134 patients with dTRA (110 successful, 24 unsuccessful) were included in the study. dTRA is comsidered to be an access to the anatomical snuffbox. Completion of the entire procedure, not just a successful puncture or insertion of an introducer, was considered the access successful. Results: It was found that the success of the method was 82% of the criteria preset. Among the successful procedures, 48% were interventions. Of these, 71% had ACS and 43.6% had STEMI. The access was used on 3 patients who had CTO. Two patients underwent rotablation using a 7 in 6 Fr introduser. On 98% of the patients a 6 Fr introducer was used. Right dTRA was used on 93% of patients. From the 134 procedures performed, it was found that 92% of failures were up to the 80th procedures. After the 80’th procedures the frequency of failures decreased significantly. Complications ‒ 3 small hematomas and 2 numbness in the thumb, which did not require additional interventions. Conclusion: The procedure with dTRA was successfully completed by high percentage of patients, including the high-risk patients with ACS and STEMI. After the 80th dTRA procedure was reached level of skills with a low frequency of failed procedures. This suggests that dTRA can be an alternative to standard radial access to prevent radial artery occlusion, which has been confirmed by previous studies, better patient comfort, and lower risk of complications. The results were achieved without the need of reduction of the introducer’s diameter or use of special devices for hemostasis.
引言:通过桡动脉(cTRA)进行常规介入治疗是冠状动脉介入治疗的标准方法。不幸的是,它有长期并发症的风险,如桡动脉闭塞(RAO)和局部并发症,通常是血肿。目的:分享远端经桡动脉入路(dTRA)在134名患者中的初步应用经验,来自一个中心的单一操作员及其在STEMI患者中的适用性。获得这种访问经验所需的程序数量,根据失败程序的减少程度进行评估。材料和方法:从2011年3月8日至2011年12月18日,134名dTRA患者(110例成功,24例不成功)被纳入研究。dTRA被认为是进入解剖鼻烟盒的通道。完成整个手术,而不仅仅是成功穿刺或插入介绍器,被认为是成功的进入。结果:该方法的成功率为预设标准的82%。在成功的手术中,48%是干预措施。其中,71%患有ACS,43.6%患有STEMI。该通路用于3名CTO患者。两名患者使用7/6Fr插入器进行了旋转清除术。98%的患者使用了6Fr导引器。93%的患者使用了正确的dTRA。在进行的134次手术中,发现92%的失败发生在第80次手术之前。在第80次手术后,失败的频率显著降低。并发症——3例小血肿和2例拇指麻木,不需要额外干预。结论:dTRA手术成功率高,包括ACS和STEMI的高危患者。在第80次dTRA手术后,达到了失败率较低的技能水平。这表明,dTRA可以作为标准桡动脉介入的替代方案,以预防桡动脉闭塞,这一点已被先前的研究证实,可以改善患者的舒适度,降低并发症的风险。无需缩小导入器直径或使用特殊止血装置即可达到上述效果。
{"title":"Distal transradial access. Initial experience. Results","authors":"M. Mihalev","doi":"10.3897/bgcardio.28.e79042","DOIUrl":"https://doi.org/10.3897/bgcardio.28.e79042","url":null,"abstract":"Introduction: Conventional access through the radial artery (cTRA) is a standard approach in coronary interventions. Unfortunately, it carries a risk of long-term complications such as radial artery occlusion (RAO) and local complications, usually hematomas. Aim: Sharing initial experience in the application of distal transradial access (dTRA) on 134 patients, from single operator in one center and its applicability on patients with STEMI. Number of procedures required to get experience with this access, assessed by the degree of reduction of failed procedures. Materials and methods: From 08.03.21 to 18.11.21, 134 patients with dTRA (110 successful, 24 unsuccessful) were included in the study. dTRA is comsidered to be an access to the anatomical snuffbox. Completion of the entire procedure, not just a successful puncture or insertion of an introducer, was considered the access successful. Results: It was found that the success of the method was 82% of the criteria preset. Among the successful procedures, 48% were interventions. Of these, 71% had ACS and 43.6% had STEMI. The access was used on 3 patients who had CTO. Two patients underwent rotablation using a 7 in 6 Fr introduser. On 98% of the patients a 6 Fr introducer was used. Right dTRA was used on 93% of patients. From the 134 procedures performed, it was found that 92% of failures were up to the 80th procedures. After the 80’th procedures the frequency of failures decreased significantly. Complications ‒ 3 small hematomas and 2 numbness in the thumb, which did not require additional interventions. Conclusion: The procedure with dTRA was successfully completed by high percentage of patients, including the high-risk patients with ACS and STEMI. After the 80th dTRA procedure was reached level of skills with a low frequency of failed procedures. This suggests that dTRA can be an alternative to standard radial access to prevent radial artery occlusion, which has been confirmed by previous studies, better patient comfort, and lower risk of complications. The results were achieved without the need of reduction of the introducer’s diameter or use of special devices for hemostasis.","PeriodicalId":33976,"journal":{"name":"B''lgarska kardiologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44675621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A clinical case of a patient after COVID 19 infection and a thrombus in the right atrium, deep phlebothrombosis, and pulmonary embolism 新冠肺炎感染后右心房血栓形成、深静脉血栓形成、肺栓塞1例
Pub Date : 2022-09-30 DOI: 10.3897/bgcardio.28.e86417
I. Tasheva, M. Miletieva
Background: The coronavirus disease (COVID-19 disease) leads to multiple organ disease, inflammation of the endothelium, and micro- or macrovasculitis that may result in thrombosis of the small vessels, and thrombosis of vessels in various organs, as well as intracardiac thrombosis. Some of the complications may be long-lasting, as in our case, which makes it particularly interesting to discuss. Case report: We present a 73-year-old male patient with a history of permanent atrial fibrillation and chronic heart failure (II NYHA class), popliteal phlebothrombosis, and surgery of the left hip joint. 53 days after a positive rapid test for Covid 19 performed because of fever and coughing, the patient, who is not vaccinated for Covid 19, was hospitalised at our Department with clinical signs of mild respiratory failure and cardiogenic shock.  The laboratory tests revealed elevated markers of inflammation. The ECG showed tachyarrhythmia (170/min) and atrial fibrillation. The EchoCG displayed evidence of right systolic dysfunction, pulmonary hypertension, and a massive thrombus in the right atrium. The Doppler ultrasonography revealed the presence of right femoropopliteal thrombosis, while the CT-pulmoangiography showed evidence of massive bilateral PE. A decision was made to perform systemic fibrinolysis, which the patient tolerated without complications. During the hospitalisation, the examinations revealed no evidence of an oncological disease. Conclusion: The reported clinical case confirms the high risk of thrombosis due to a COVID-19 infection, such as phlebothrombosis, atrial thrombosis, and massive bilateral PE, in the absence of optimal anticoagulant therapy and against the backdrop of the administration of antiplatelet therapy roughly 2 months after the onset of the COVID-19 symptoms.
背景:新型冠状病毒病(COVID-19病)可导致多器官病变、内皮细胞炎症、微血管炎或大血管炎,可导致小血管血栓形成、各器官血管血栓形成、心内血栓形成。有些并发症可能是长期的,就像我们的情况一样,这使得讨论特别有趣。病例报告:我们报告一名73岁男性患者,有永久性心房颤动和慢性心力衰竭(II NYHA级),腘静脉血栓形成和左髋关节手术史。在因发烧和咳嗽而进行的Covid - 19快速检测呈阳性53天后,未接种Covid - 19疫苗的患者因轻度呼吸衰竭和心源性休克的临床症状在我科住院。实验室检查显示炎症标志物升高。心电图显示心律失常(170/min)及心房颤动。超声心动图显示右侧收缩功能障碍,肺动脉高压,右心房有大块血栓。多普勒超声显示右侧股腘血栓形成,ct -肺造影显示双侧大量PE。决定进行全身纤溶,患者耐受无并发症。在住院期间,检查没有发现肿瘤疾病的证据。结论:本例临床病例证实,在没有最佳抗凝治疗的情况下,在出现COVID-19症状约2个月后给予抗血小板治疗的背景下,患者因COVID-19感染而出现血栓形成的高风险,如静脉血栓形成、心房血栓形成、双侧大量PE。
{"title":"A clinical case of a patient after COVID 19 infection and a thrombus in the right atrium, deep phlebothrombosis, and pulmonary embolism","authors":"I. Tasheva, M. Miletieva","doi":"10.3897/bgcardio.28.e86417","DOIUrl":"https://doi.org/10.3897/bgcardio.28.e86417","url":null,"abstract":"Background: The coronavirus disease (COVID-19 disease) leads to multiple organ disease, inflammation of the endothelium, and micro- or macrovasculitis that may result in thrombosis of the small vessels, and thrombosis of vessels in various organs, as well as intracardiac thrombosis. Some of the complications may be long-lasting, as in our case, which makes it particularly interesting to discuss. Case report: We present a 73-year-old male patient with a history of permanent atrial fibrillation and chronic heart failure (II NYHA class), popliteal phlebothrombosis, and surgery of the left hip joint. 53 days after a positive rapid test for Covid 19 performed because of fever and coughing, the patient, who is not vaccinated for Covid 19, was hospitalised at our Department with clinical signs of mild respiratory failure and cardiogenic shock.  The laboratory tests revealed elevated markers of inflammation. The ECG showed tachyarrhythmia (170/min) and atrial fibrillation. The EchoCG displayed evidence of right systolic dysfunction, pulmonary hypertension, and a massive thrombus in the right atrium. The Doppler ultrasonography revealed the presence of right femoropopliteal thrombosis, while the CT-pulmoangiography showed evidence of massive bilateral PE. A decision was made to perform systemic fibrinolysis, which the patient tolerated without complications. During the hospitalisation, the examinations revealed no evidence of an oncological disease. Conclusion: The reported clinical case confirms the high risk of thrombosis due to a COVID-19 infection, such as phlebothrombosis, atrial thrombosis, and massive bilateral PE, in the absence of optimal anticoagulant therapy and against the backdrop of the administration of antiplatelet therapy roughly 2 months after the onset of the COVID-19 symptoms.","PeriodicalId":33976,"journal":{"name":"B''lgarska kardiologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41713092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endovascular treatment of subclavian artery stenosis 锁骨下动脉狭窄的血管内治疗
Pub Date : 2022-09-30 DOI: 10.3897/bgcardio.28.e91105
I. Petrov, Z. Stankov, J. Stoykova, G. Zlatancheva, S. Vasilev, I. Tasheva, K. Vaseva
The most common localizations for upper extremity atherosclerosis are the subclavian artery and the brachiocephalic trunk. Significant stenosis of the subclavian artery occurs in 2% of the population and in 7-11% of patients with manifest cardiovascular disease. Revascularization is indicated in symptomatic or asymptomatic patients with coronary disease with planned surgical revascularization. In addition to atherosclerosis, other causes of the appearance of subclavian artery stenosis include dissection, radiation-induced inflammation of the fibromusculature, and various vasculities, especially Takayasu arteritis. The left subclavian artery is about four times more commonly affected than the right. It usually occurs over the age of 50 years and in 1.5-2 times more common in men than in women. Disease of the subclavian artery is usually focal and the lesion is predominantly in the first 2 cm proximal to the origin of the aorta. Between 2016-2021 in the clinic of cardiology and angiology we treated endovascularly 81 patients (41 men and 40 females, median age 64 ± 11) with either intraluminal balloon dilatation and/or primary stent implantation followed by balloon post dilatation. We achieved a high technical success rate (93.8%) and immediate clinical success, with only a few minor complications. 
上肢动脉粥样硬化最常见的部位是锁骨下动脉和头臂干。锁骨下动脉明显狭窄发生在2%的人群和7-11%的明显心血管疾病患者中。血运重建适用于有症状或无症状的冠状动脉疾病患者,并计划进行手术血运重建。除了动脉粥样硬化外,锁骨下动脉狭窄的其他原因包括夹层、放射性引起的纤维肌肉组织炎症和各种血管,尤其是大动脉炎。左锁骨下动脉受到的影响大约是右锁骨下动脉的四倍。它通常发生在50岁以上,男性的发病率是女性的1.5-2倍。锁骨下动脉的疾病通常是局灶性的,病变主要发生在主动脉起点附近的前2cm。2016-2021年间,在心脏病学和血管病临床,我们对81名血管内患者(41名男性和40名女性,中位年龄64±11岁)进行了腔内球囊扩张和/或初次支架植入,然后进行球囊后扩张。我们获得了很高的技术成功率(93.8%)和即时的临床成功,只有少数轻微并发症。
{"title":"Endovascular treatment of subclavian artery stenosis","authors":"I. Petrov, Z. Stankov, J. Stoykova, G. Zlatancheva, S. Vasilev, I. Tasheva, K. Vaseva","doi":"10.3897/bgcardio.28.e91105","DOIUrl":"https://doi.org/10.3897/bgcardio.28.e91105","url":null,"abstract":"The most common localizations for upper extremity atherosclerosis are the subclavian artery and the brachiocephalic trunk. Significant stenosis of the subclavian artery occurs in 2% of the population and in 7-11% of patients with manifest cardiovascular disease. Revascularization is indicated in symptomatic or asymptomatic patients with coronary disease with planned surgical revascularization. In addition to atherosclerosis, other causes of the appearance of subclavian artery stenosis include dissection, radiation-induced inflammation of the fibromusculature, and various vasculities, especially Takayasu arteritis. The left subclavian artery is about four times more commonly affected than the right. It usually occurs over the age of 50 years and in 1.5-2 times more common in men than in women. Disease of the subclavian artery is usually focal and the lesion is predominantly in the first 2 cm proximal to the origin of the aorta. Between 2016-2021 in the clinic of cardiology and angiology we treated endovascularly 81 patients (41 men and 40 females, median age 64 ± 11) with either intraluminal balloon dilatation and/or primary stent implantation followed by balloon post dilatation. We achieved a high technical success rate (93.8%) and immediate clinical success, with only a few minor complications. ","PeriodicalId":33976,"journal":{"name":"B''lgarska kardiologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45243388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interventional treatment of pulmonary embolism - where do we currently stand? 肺栓塞的介入治疗——我们目前的立场是什么?
Pub Date : 2022-09-29 DOI: 10.3897/bgcardio.28.e89800
G. Dobrev, I. Petrov, Z. Stankov, I. Tasheva, P. Polomski
Acute pulmonary embolism is the third most common cause of cardiovascular mortality in the world. The sudden pressure overload of the right ventricle, caused by the thrombotic masses in the pulmonary artery, may quickly progress to profound cardiogenic shock. That results in a mortality rate of more than 50% in patients with a massive form of pulmonary embolism. In such cases, systemic fibrinolysis is warranted, which leads to rapid improvement of the right ventricular function and hemodynamic stabilization. The thrombolytic effect of systemic fibrinolysis is, unfortunately, accompanied by an almost 5 times increased risk of bleeding, especially intracranial one. Therefore, in most cases, for patients with uncompromised hemodynamics, only anticoagulation treatment is offered. Interventional treatment of acute pulmonary embolism consists of the usage of very low-dose fibrinolytic devices or percutaneous thrombus aspiration devices. The goal is to provide rapid removal of the thrombotic masses from the pulmonary artery circulation while keeping the hemorrhagic risk at a minimum. This paper will try to provide a concise review of the most widely used and available devices, together with the latest clinical data, supporting their use. Also, the future perspectives in the field of endovascular treatment of acute pulmonary embolism will be presented.
急性肺栓塞是世界上第三大最常见的心血管死亡原因。由肺动脉血栓性肿块引起的右心室突然压力过载可能迅速发展为深度心源性休克。这导致患有严重肺栓塞的患者死亡率超过50%。在这种情况下,全身纤溶是必要的,这导致右心室功能和血流动力学稳定的快速改善。不幸的是,全身纤溶的溶栓作用伴随着出血风险增加近5倍,尤其是颅内出血。因此,在大多数情况下,对于血流动力学未受损的患者,只提供抗凝治疗。急性肺栓塞的介入治疗包括使用极低剂量的纤溶装置或经皮血栓吸入装置。目的是快速清除肺动脉循环中的血栓块,同时将出血风险降至最低。本文将尝试提供最广泛使用和可用的设备的简明回顾,以及最新的临床数据,支持他们的使用。此外,本文还将对急性肺栓塞血管内治疗的前景进行展望。
{"title":"Interventional treatment of pulmonary embolism - where do we currently stand?","authors":"G. Dobrev, I. Petrov, Z. Stankov, I. Tasheva, P. Polomski","doi":"10.3897/bgcardio.28.e89800","DOIUrl":"https://doi.org/10.3897/bgcardio.28.e89800","url":null,"abstract":"Acute pulmonary embolism is the third most common cause of cardiovascular mortality in the world. The sudden pressure overload of the right ventricle, caused by the thrombotic masses in the pulmonary artery, may quickly progress to profound cardiogenic shock. That results in a mortality rate of more than 50% in patients with a massive form of pulmonary embolism. In such cases, systemic fibrinolysis is warranted, which leads to rapid improvement of the right ventricular function and hemodynamic stabilization. The thrombolytic effect of systemic fibrinolysis is, unfortunately, accompanied by an almost 5 times increased risk of bleeding, especially intracranial one. Therefore, in most cases, for patients with uncompromised hemodynamics, only anticoagulation treatment is offered. Interventional treatment of acute pulmonary embolism consists of the usage of very low-dose fibrinolytic devices or percutaneous thrombus aspiration devices. The goal is to provide rapid removal of the thrombotic masses from the pulmonary artery circulation while keeping the hemorrhagic risk at a minimum. This paper will try to provide a concise review of the most widely used and available devices, together with the latest clinical data, supporting their use. Also, the future perspectives in the field of endovascular treatment of acute pulmonary embolism will be presented.","PeriodicalId":33976,"journal":{"name":"B''lgarska kardiologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41793260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Еditorial 社论
Pub Date : 2022-09-29 DOI: 10.3897/bgcardio.28.e95811
I. Petrov
Еditorial
社论
{"title":"Еditorial","authors":"I. Petrov","doi":"10.3897/bgcardio.28.e95811","DOIUrl":"https://doi.org/10.3897/bgcardio.28.e95811","url":null,"abstract":"Еditorial","PeriodicalId":33976,"journal":{"name":"B''lgarska kardiologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43335706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shortenеd and prolonged dual antiplatelet therapy after percutaneous coronary interventions – why, when and how? 经皮冠状动脉介入治疗后缩短和延长双重抗血小板治疗——为什么、何时以及如何?
Pub Date : 2022-09-29 DOI: 10.3897/bgcardio.28.e81705
P. Gatzov
The antithrombotic therapy is an important part of medical treatment in percutaneous coronary interventions (PCI). The so called dual antiplatelet therapy (DAPT), usually including acetyl salicylic acid (aspirin) plus platelet P2Y12 receptor inhibitors is an important part of that therapy. The careful balance between the protective effect regarding thrombotic/ischemic events and the risk of bleeding is an important task of the attending physician. Apart of the standard dosing regiments, in some of the cases a judgment regarding shortened or prolonged DAPT, as its de-escalation is mandatory. To present the causes and the way of application of that individualized approach in patients with PCI is the aim of this review. 
抗血栓治疗是经皮冠状动脉介入治疗(PCI)的重要组成部分。所谓的双重抗血小板治疗(DAPT),通常包括乙酰水杨酸(阿司匹林)加血小板P2Y12受体抑制剂是该治疗的重要组成部分。在血栓形成/缺血事件和出血风险的保护作用之间的仔细平衡是主治医生的重要任务。除标准给药方案外,在某些情况下,由于DAPT的降级是强制性的,因此对缩短或延长DAPT作出判决。本综述的目的是介绍这种个体化方法在PCI患者中的应用的原因和方法。
{"title":"Shortenеd and prolonged dual antiplatelet therapy after percutaneous coronary interventions – why, when and how?","authors":"P. Gatzov","doi":"10.3897/bgcardio.28.e81705","DOIUrl":"https://doi.org/10.3897/bgcardio.28.e81705","url":null,"abstract":"The antithrombotic therapy is an important part of medical treatment in percutaneous coronary interventions (PCI). The so called dual antiplatelet therapy (DAPT), usually including acetyl salicylic acid (aspirin) plus platelet P2Y12 receptor inhibitors is an important part of that therapy. The careful balance between the protective effect regarding thrombotic/ischemic events and the risk of bleeding is an important task of the attending physician. Apart of the standard dosing regiments, in some of the cases a judgment regarding shortened or prolonged DAPT, as its de-escalation is mandatory. To present the causes and the way of application of that individualized approach in patients with PCI is the aim of this review. ","PeriodicalId":33976,"journal":{"name":"B''lgarska kardiologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46119548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiogenic shock - novelty and emerging therapeutic concepts 心源性休克——新颖和新兴的治疗概念
Pub Date : 2022-09-29 DOI: 10.3897/bgcardio.28.e87553
I. Petrov, Z. Stankov, S. Vasilev
The cardiogenic shock is a state of low cardiac output, primarily due to cardiac dysfunction, which leads to severe organ hypoperfusion with tissue hypoxia and increased lactate levels. It presents a severe complication with a prevalence of around 15% of all forms of shock and 2-5% of the cardiogenic shock is a complications of acute heart failure. Despite the diverse etiology of the cardiogenic shock, up to 80% of the cases are due to acute myocardial infarction. The ischemia, leads to dysfunction of the myocardium cells, which causes a decline in the blood pressure and subsequent tissue hypoperfusion. The most important part is to start the treatment regime as soon as possible in the pre-shock stage. The treatment of refractory cardiogenic shock is complex, as it contains an intravenous therapy with inotropes/vasopressors and mechanical circulatory support (MCS). The MCS devices are supposed to reduce the workload of the heart and the oxygen need of the myocardial cells and in the same time to maintain an adequate coronary and systemic perfusion. There are different MCS devices like IABP, Impella, Tandem Heart, V-A ECMO. The aim of this review article is to present the new trends in the treatment approach to cardiogenic shock and to bring clarity in the treatment regimes, based on the latest studies and guidelines.
心源性休克是一种心输出量低的状态,主要是由于心脏功能障碍,导致严重的器官灌注不足,伴有组织缺氧和乳酸水平升高。它是一种严重的并发症,约占所有形式休克的15%,2-5%的心源性休克是急性心力衰竭的并发症。尽管心源性休克的病因多种多样,但高达80%的病例是由急性心肌梗死引起的。缺血会导致心肌细胞功能障碍,从而导致血压下降和随后的组织灌注不足。最重要的部分是在休克前阶段尽快开始治疗。难治性心源性休克的治疗是复杂的,因为它包括静脉注射止痛药/血管升压药和机械循环支持(MCS)。MCS设备应该可以减少心脏的工作量和心肌细胞的氧气需求,同时保持足够的冠状动脉和全身灌注。有不同的MCS设备,如IABP、Impella、Tandem Heart、V-A ECMO。这篇综述文章的目的是根据最新的研究和指南,介绍心源性休克治疗方法的新趋势,并明确治疗方案。
{"title":"Cardiogenic shock - novelty and emerging therapeutic concepts","authors":"I. Petrov, Z. Stankov, S. Vasilev","doi":"10.3897/bgcardio.28.e87553","DOIUrl":"https://doi.org/10.3897/bgcardio.28.e87553","url":null,"abstract":"The cardiogenic shock is a state of low cardiac output, primarily due to cardiac dysfunction, which leads to severe organ hypoperfusion with tissue hypoxia and increased lactate levels. It presents a severe complication with a prevalence of around 15% of all forms of shock and 2-5% of the cardiogenic shock is a complications of acute heart failure. Despite the diverse etiology of the cardiogenic shock, up to 80% of the cases are due to acute myocardial infarction. The ischemia, leads to dysfunction of the myocardium cells, which causes a decline in the blood pressure and subsequent tissue hypoperfusion. The most important part is to start the treatment regime as soon as possible in the pre-shock stage. The treatment of refractory cardiogenic shock is complex, as it contains an intravenous therapy with inotropes/vasopressors and mechanical circulatory support (MCS). The MCS devices are supposed to reduce the workload of the heart and the oxygen need of the myocardial cells and in the same time to maintain an adequate coronary and systemic perfusion. There are different MCS devices like IABP, Impella, Tandem Heart, V-A ECMO. The aim of this review article is to present the new trends in the treatment approach to cardiogenic shock and to bring clarity in the treatment regimes, based on the latest studies and guidelines.","PeriodicalId":33976,"journal":{"name":"B''lgarska kardiologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49382074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum biomarkers for pulmonary hypertension 肺动脉高压的血清生物标志物
Pub Date : 2022-06-20 DOI: 10.3897/bgcardio.28.e79181
T. Boneva, R. Ivanova, G. Zlatantcheva, D. Vasilev, K. Karamfiloff
In the fi eld of development of pathophysiology of pulmonary hypertension, there are growing number of signifi cant recent advances, which leads to new therapeutic agents. Traditional methods of diagnosing and monitoring this condition have comprised echocardiography and right heart catheterization, in addition to functional measures, such as estimation of functional class and the 6-min walk test. An increasing number of biomarkers have been described that are elevated in pulmonary hypertension and which may assist the clinician in diagnosis and in the assessment of disease severity and response to treatment.  
在肺动脉高压病理生理学发展领域,有越来越多的重要进展,这导致了新的治疗药物。诊断和监测这种情况的传统方法包括超声心动图和右心导管插入术,以及功能测量,如功能等级估计和6分钟步行测试。已经描述了越来越多的在肺动脉高压中升高的生物标志物,这些生物标志物可以帮助临床医生诊断和评估疾病的严重程度和对治疗的反应。
{"title":"Serum biomarkers for pulmonary hypertension","authors":"T. Boneva, R. Ivanova, G. Zlatantcheva, D. Vasilev, K. Karamfiloff","doi":"10.3897/bgcardio.28.e79181","DOIUrl":"https://doi.org/10.3897/bgcardio.28.e79181","url":null,"abstract":"In the fi eld of development of pathophysiology of pulmonary hypertension, there are growing number of signifi cant recent advances, which leads to new therapeutic agents. Traditional methods of diagnosing and monitoring this condition have comprised echocardiography and right heart catheterization, in addition to functional measures, such as estimation of functional class and the 6-min walk test. An increasing number of biomarkers have been described that are elevated in pulmonary hypertension and which may assist the clinician in diagnosis and in the assessment of disease severity and response to treatment.\u0000  ","PeriodicalId":33976,"journal":{"name":"B''lgarska kardiologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44054520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interventional electrophysiology in Bulgaria in 2021: data from the electronic registry BG-EPHY 2021年保加利亚的介入电生理学:来自电子注册表BG-EPHY的数据
Pub Date : 2022-06-20 DOI: 10.3897/bgcardio.28.e82407
T. Shalganov, M. Stoyanov, V. Traykov
This study presents data from the national electronic registry BG-EPHY on electrophysiologic (EP) cardiac ablations in 2021. Material and methods: This is a retrospective study of a full one-year sample of the BG-EPHY registry. Sex and age distribution of the patients, number of ablations, electroanatomic mapping (EAM), irrigated and cryoablations, distribution of different types of arrhythmias, acute procedural success and complications are presented. Results: In 2021 fi ve EP centers performed 872 ablations in 546 men (62.6%) and 326 women (4.4% increase compared to previous year), incl. 6 ablations in pediatric patients (0.7%). EAM was used in 60.9% of the procedures, irrigation catheter was used in 55.2%, cryoballoon catheter – in 6%, and intracardiac echocardiography – in 4.2%. The most common ablation was pulmonary vein isolation, followed by ablation for AV nodal reentrant tachycardia and typical atrial fl utter. The acute success was over 98%, while intraprocedural complications were less than 2%. Conclusion: The national registry of electrophysiology collects systematically and continuously basic data on all ablations of cardiac arrhythmias performed in the country. In 2021, during a continuing COVID-19 pandemic the number of ablations increased slightly compared to the previous year. Distribution of EP procedure types was similar to previous years. Acute success was very high, while intraprocedural complications were rare.
这项研究提供了2021年国家电子登记处BG-EPHY关于电生理(EP)心脏消融的数据。材料和方法:这是一项为期一年的BG-EPHY注册样本的回顾性研究。介绍了患者的性别和年龄分布、消融次数、电解剖标测(EAM)、灌注消融和冷冻消融、不同类型心律失常的分布、急性手术成功率和并发症。结果:2021年,五个EP中心对546名男性(62.6%)和326名女性(比前一年增加4.4%)进行了872次消融,其中包括6名儿科患者(0.7%)。60.9%的手术使用EAM,55.2%使用冲洗导管,6%使用冷冻球囊导管,4.2%使用心内超声心动图。最常见的消融是肺静脉隔离,然后对房室结折返性心动过速和典型的心房颤动进行消融。急性成功率超过98%,而术中并发症不到2%。结论:国家电生理学登记处系统、连续地收集了国内所有心律失常消融的基础数据。2021年,在持续的新冠肺炎大流行期间,消融次数比前一年略有增加。EP手术类型的分布与前几年相似。急性成功率很高,而术中并发症很少。
{"title":"Interventional electrophysiology in Bulgaria in 2021: data from the electronic registry BG-EPHY","authors":"T. Shalganov, M. Stoyanov, V. Traykov","doi":"10.3897/bgcardio.28.e82407","DOIUrl":"https://doi.org/10.3897/bgcardio.28.e82407","url":null,"abstract":"This study presents data from the national electronic registry BG-EPHY on electrophysiologic (EP) cardiac ablations in 2021. Material and methods: This is a retrospective study of a full one-year sample of the BG-EPHY registry. Sex and age distribution of the patients, number of ablations, electroanatomic mapping (EAM), irrigated and cryoablations, distribution of different types of arrhythmias, acute procedural success and complications are presented. Results: In 2021 fi ve EP centers performed 872 ablations in 546 men (62.6%) and 326 women (4.4% increase compared to previous year), incl. 6 ablations in pediatric patients (0.7%). EAM was used in 60.9% of the procedures, irrigation catheter was used in 55.2%, cryoballoon catheter – in 6%, and intracardiac echocardiography – in 4.2%. The most common ablation was pulmonary vein isolation, followed by ablation for AV nodal reentrant tachycardia and typical atrial fl utter. The acute success was over 98%, while intraprocedural complications were less than 2%. Conclusion: The national registry of electrophysiology collects systematically and continuously basic data on all ablations of cardiac arrhythmias performed in the country. In 2021, during a continuing COVID-19 pandemic the number of ablations increased slightly compared to the previous year. Distribution of EP procedure types was similar to previous years. Acute success was very high, while intraprocedural complications were rare.","PeriodicalId":33976,"journal":{"name":"B''lgarska kardiologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46096252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The predictive role of fully revascularized coronary artery disease in patients undergoing transaortic valve implantation 完全血运重建的冠状动脉疾病在经主动脉瓣植入患者中的预测作用
Pub Date : 2022-06-20 DOI: 10.3897/bgcardio.28.e82423
R. Pencheva, J. Shabani, D. Trendafilova, J. Jorgova, H. Angelov, P. Simeonov, I. Dimitrova
In the modern days and the era of the rapid development of medical technology, the introduction of innovative invasive methods of treatment is gradually displacing traditional conventional surgery. In 2002 was performed the fi rst transcatheter implantation of an aortic valve. Over the next twenty years, with the advancement of technology and the accumulation of experience in clinical centers, transcatheter aortic valve implantation has become the standard in adult and high-risk patients with high-grade Ao stenosis. In a large percentage of cases enrolled under the transcatheter aortic valve protocol a concomitant ischemic heart disease is detected or known. Globally, there is no signifi cant difference in overall mortality on the thirtieth day after TAVI in patients with ischemic heart disease. However, the overall mortality was signifi cantly higher in one – year follow - up of patients after transcatheter aortic valve implantation with underlying coronary pathology. We conducted a study comparing the number of late and early adverse events in patients with concomitant fully revascularized ischemic heart disease and those with insignifi cant coronary atherosclerosis. Based on the data collected, analyzed and summarized in our clinical center, fully revascularized ischemic heart disease does not increase the percentage of major adverse events after transcatheter aortic valve implantation. It can be considered when assessing the risk of transcatheter aortic implantation, as part of the individual approach for each case.
在当今医疗技术飞速发展的时代,创新的侵入性治疗方法的引入正逐渐取代传统的常规手术。2002年进行了第一例经导管主动脉瓣植入术。在接下来的二十年里,随着技术的进步和临床中心经验的积累,经导管主动脉瓣植入术已成为成人和高危高级别Ao狭窄患者的标准。在经导管主动脉瓣方案下登记的大部分病例中,检测到或已知伴有缺血性心脏病。在全球范围内,缺血性心脏病患者TAVI后第30天的总死亡率无显著差异。然而,经导管主动脉瓣置入术后有潜在冠状动脉病变的患者,在一年的随访中,总死亡率明显更高。我们进行了一项研究,比较了合并完全血运重建的缺血性心脏病患者和不明显冠状动脉粥样硬化患者的晚期和早期不良事件的数量。根据我们临床中心收集、分析和总结的数据,经导管主动脉瓣植入术后,完全血运重建的缺血性心脏病不会增加主要不良事件的百分比。在评估经导管主动脉植入术的风险时,可以考虑将其作为每个病例的个别方法的一部分。
{"title":"The predictive role of fully revascularized coronary artery disease in patients undergoing transaortic valve implantation","authors":"R. Pencheva, J. Shabani, D. Trendafilova, J. Jorgova, H. Angelov, P. Simeonov, I. Dimitrova","doi":"10.3897/bgcardio.28.e82423","DOIUrl":"https://doi.org/10.3897/bgcardio.28.e82423","url":null,"abstract":"In the modern days and the era of the rapid development of medical technology, the introduction of innovative invasive methods of treatment is gradually displacing traditional conventional surgery. In 2002 was performed the fi rst transcatheter implantation of an aortic valve. Over the next twenty years, with the advancement of technology and the accumulation of experience in clinical centers, transcatheter aortic valve implantation has become the standard in adult and high-risk patients with high-grade Ao stenosis. In a large percentage of cases enrolled under the transcatheter aortic valve protocol a concomitant ischemic heart disease is detected or known. Globally, there is no signifi cant difference in overall mortality on the thirtieth day after TAVI in patients with ischemic heart disease. However, the overall mortality was signifi cantly higher in one – year follow - up of patients after transcatheter aortic valve implantation with underlying coronary pathology. We conducted a study comparing the number of late and early adverse events in patients with concomitant fully revascularized ischemic heart disease and those with insignifi cant coronary atherosclerosis. Based on the data collected, analyzed and summarized in our clinical center, fully revascularized ischemic heart disease does not increase the percentage of major adverse events after transcatheter aortic valve implantation. It can be considered when assessing the risk of transcatheter aortic implantation, as part of the individual approach for each case.","PeriodicalId":33976,"journal":{"name":"B''lgarska kardiologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41707103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
B''lgarska kardiologiia
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1