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The role of cardiac surgery in the treatment of acute coronary syndrome with stelevation 心脏手术在急性冠状动脉综合征合并抬高治疗中的作用
Pub Date : 2023-04-07 DOI: 10.3897/bgcardio.29.e100372
D. Kyuchukov
Percutaneous coronary revascularization of the „culprit“ lesion is the most contemporary method of treating patients with acute coronary syndrome (ACS) of all forms. In the management of acute ST-elevation myocardial infarction (STEMI), cardiac surgery remains, in most cases, a third option following PCI and thrombolysis, nevertheless serves an important role in a select subgroups of patients. This review will discuss current indications and potentiality of cardiac surgery in the treatment of patients with STEMI.
经皮冠状动脉血管重建术是治疗各种急性冠状动脉综合征(ACS)的最新方法。在急性st段抬高型心肌梗死(STEMI)的治疗中,在大多数情况下,心脏手术仍然是PCI和溶栓之后的第三种选择,尽管如此,在特定的亚组患者中仍起着重要作用。这篇综述将讨论目前心脏手术治疗STEMI患者的适应症和潜力。
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引用次数: 0
Impact of baseline anemia on the short- and long-term prognosis of patients presenting with non-ST-elevation myocardial infarction 基线贫血对非ST段抬高型心肌梗死患者短期和长期预后的影响
Pub Date : 2023-04-07 DOI: 10.3897/bgcardio.29.e100441
I. Bayraktarova, G. Vladimirov, H. Mateev, A. Alexandrov, E. Trendafilova
Anaemia at admission is a known predictor of death in patients with myocardial infarction with ST-elevation (STEMI). Data on the effect of anaemia on the prognosis in patients with non-ST-elevation myocardial infarction (NSTEMI) is less readily available. Purpose: We aimed to evaluate the frequency of anaemia in a Bulgarian tertiary centre NSTEMI patient population, and its effect on the immediate and extended prognosis of the patients. Methods: We performed ambispective analysis of 138 consecutive patients with NSTEMI, and anaemia was defi ned as haemoglobin at admission below 120 g/L for females and below 130 g/L for males. Results: There was no signifi cant difference in the frequencies of standard risk factors between patients with and without anaemia. Anaemic patients tended to be older, with lower body mass index and worse kidney function. Patients with baseline anaemia tended to have higher GRACE risk scores and a larger size of the realised myocardial infarction as judged by maximal reached troponin I. There was no signifi cant difference in interventional treatment in both groups. Median hospital stay was signifi cantly longer in anaemic patients and was marked by more complications. Despite a lack of increase in inhospital bleeding and no difference in treatment with oral antiaggregants, patients with anaemia received haemotransfusion treatment more often. Mortality rate was higher in anaemic patients both during the index hospitalization and during the follow up. Conclusion: Anaemia at admission is associated with an increased risk of both in hospital cardiovascular complications and after dehospitalisation all-cause mortality in patients with NSTEMI and should be considered as an additional risk factor in the global risk assessment of patients.
入院时贫血是ST段抬高心肌梗死(STEMI)患者死亡的已知预测因素。关于贫血对非ST段抬高型心肌梗死(NSTEMI)患者预后影响的数据不太容易获得。目的:我们旨在评估保加利亚三级中心NSTEMI患者群体中贫血的频率及其对患者即时和长期预后的影响。方法:我们对138名连续的NSTEMI患者进行了前瞻性分析,贫血被定义为女性入院时血红蛋白低于120g/L,男性入院时低于130g/L。结果:贫血患者和非贫血患者的标准危险因素频率没有显著差异。贫血患者往往年龄较大,体重指数较低,肾功能较差。根据肌钙蛋白I的最大值判断,基线贫血患者的GRACE风险评分往往更高,实际心肌梗死的范围更大。两组的介入治疗没有显著差异。贫血患者的中位住院时间明显较长,并发症较多。尽管住院出血没有增加,口服抗聚集剂的治疗也没有差异,但贫血患者接受输血治疗的频率更高。贫血患者在指数住院期间和随访期间的死亡率都较高。结论:NSTEMI患者入院时贫血与院内心血管并发症和出院后全因死亡率的风险增加有关,应将其视为患者总体风险评估中的一个额外风险因素。
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引用次数: 0
Impact of the COVID-19 pandemic on the incidence and prognosis of acute myocardial infarction - a single-center restrospective analysis COVID-19大流行对急性心肌梗死发病率和预后的影响——单中心回顾性分析
Pub Date : 2023-04-07 DOI: 10.3897/bgcardio.29.e98397
E. Dimitrova, E. Trendafilova, S. Nateva, S. Georgieva, E. Kostova, G. Hristova, A. Alexandrov, H. Mateev, G. Vladimirov
Introduction: COVID-19 pandemic has led to a signifi cant change in the incidence and prognosis of acute myocardial infarction (AMI) by indirect and direct mechanisms. Aim: To assess the impact of the COVID-19 pandemic on the incidence and prognosis of AMI. Material and methods: We performed a retrospective analysis of consecutive patients with AMI (STEMI and NSTEMI) during two time periods – the complete lockdown in Bulgaria and one of the waves of the pandemic. We compared patients’ risk profi le, index event, investigations and treatment to a control group from the pre-pandemic period. Results: During the fi rst period we included 52 patients with AMI without COVID-19 and compared them to a control group of 66 patients. We found a decrease primarily in the number of patients with STEMI. The scores for assessing diseaseseverity (GRACE, APACHE II, SOFA) were higher in 2020 compared to the pre-pandemic period. More patients presented with acute congestive heart failure, mortality was similar. During the second period we included 83 patients, 21 of them with COVID-19 infection. System delay was increased in all patients. Disease severity scores and baseline troponin were higher especially in the COVID-19 group. In-hospital mortality was substantially higher in patients with COVID-19 compared to controls (23,8% versus 9%, р = 0,0375), probably due to increased incidence of cardiogenic shock and need for mechanical ventilation. Conclusion: During the complete lockdown there was a reduction in the number of patients admitted with AMI, higher incidence of acute congestive heart failure and similar mortality. During one of the waves of the pandemic we found a signifi cant increase in system delay, not exceeding the recommended time frame of 120 minutes, and in disease severity in all patients. Concomitant COVID-19 infection was associated with higher in-hospital mortality due to increased incidence of cardiogenic shock and need for mechanical ventilation.
新冠肺炎大流行通过间接和直接机制导致急性心肌梗死(AMI)的发病率和预后发生显著变化。目的:探讨新型冠状病毒肺炎(COVID-19)大流行对急性心肌梗死(AMI)发病及预后的影响。材料和方法:我们对两个时间段(保加利亚完全封锁和大流行的其中一波)连续AMI患者(STEMI和NSTEMI)进行了回顾性分析。我们将患者的风险概况、指数事件、调查和治疗与大流行前时期的对照组进行了比较。结果:在第一阶段,我们纳入52例无COVID-19的AMI患者,并将其与66例对照组患者进行比较。我们发现主要是STEMI患者数量的减少。与大流行前相比,2020年评估疾病严重程度的得分(GRACE、APACHE II、SOFA)更高。更多的患者出现急性充血性心力衰竭,死亡率相似。在第二阶段,我们纳入了83例患者,其中21例感染了COVID-19。所有患者的系统延迟均增加。疾病严重程度评分和基线肌钙蛋白水平较高,特别是在COVID-19组。与对照组相比,COVID-19患者的住院死亡率要高得多(23.8%对9%,r = 0,0375),这可能是由于心源性休克发生率增加和需要机械通气所致。结论:在完全封锁期间,AMI患者入院人数减少,急性充血性心力衰竭发病率升高,死亡率相似。在大流行的一波中,我们发现系统延迟显著增加,未超过建议的120分钟的时间范围,并且所有患者的疾病严重程度都有所增加。由于心源性休克的发生率增加和机械通气的需要,合并的COVID-19感染与更高的住院死亡率相关。
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引用次数: 0
Acute myocardial infarction – a historical review 急性心肌梗死的历史回顾
Pub Date : 2023-04-07 DOI: 10.3897/bgcardio.29.e101955
N. Gotcheva
The last 120 years have witnessed famous physicians and pathologists connected their medical investigation to study pathophysiology, diagnostics and treatment of acute myocardial infarction (AMI). Modern treatment algorithms based on precise and refi ned new technologies have as a main target to achieve rapid reperfusion and salvage threatened myocardium in order to enhance patients’ recovery and also to decrease mortality rate. Although long-lasting and multiple studies appeared to have impressive results, there still exist unknown or disputable viewpoints/concepts concerning for example the appearance of the reperfusion injuries, left ventricular remodeling, AMI in patients with normal coronary arteries, identifi cation of vulnerable lesions or plaques which are threatened by rupture or fi ssuring. This short historical review is aimed to remind us the evolution of the AMI knowledge and also to pull out some of the forgotten but relevant milestone hypothesis, as well as to help shaping the modern management of AMI.
在过去的120年里,著名的医生和病理学家将他们的医学研究结合起来,研究急性心肌梗死(AMI)的病理生理学、诊断和治疗。现代治疗算法基于精确和完善的新技术,以实现快速再灌注和挽救危重心肌,以提高患者的恢复和降低死亡率为主要目标。尽管长期和多项研究似乎取得了令人印象深刻的结果,但仍然存在未知或有争议的观点/概念,例如再灌注损伤的外观,左心室重构,正常冠状动脉患者的AMI,易损病变或斑块的识别,这些病变或斑块可能破裂或破裂。这篇简短的历史回顾旨在提醒我们AMI知识的演变,并提出一些被遗忘但相关的里程碑假设,以及帮助塑造AMI的现代管理。
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引用次数: 0
Midventricular variant of Takotsubo syndrome in a patient with threatening status epilepticus from simple motor seizures Takotsubo综合征的中心室变异在一例单纯运动性癫痫发作引起的威胁性癫痫持续状态患者中的应用
Pub Date : 2022-12-31 DOI: 10.3897/bgcardio.28.e93473
B. Kunev, V. Vasilev, G. Vladimirov, V. Karabinov
We present a clinical case of a 70-year-old woman who was urgently admitted to the Department of Neurology with threatening status epilepticus from simple motor seizures in the right half of the face and right hand. Computed tomography of the head visualized a calcified extra axial round formation in the left posterofrontal, possibly a meningioma. On admission and during the symptomatic attacks, dynamic ECG changes were recorded with negative T waves precordially, as well as a dynamic increase in serum troponin. Echocardiography revealed hypokinesia involving the middle segments of the left ventricle. Coronary angiography was performed with no evidence of coronary disease. From the ventriculography hypokinesia of middle segments was found and measured EF 47%. Complex therapy with valproate, dexamethasone, mannitol and clonazepam, levetiracetam, acetizal, a statin and a beta-blocker was initiated. After controlling the epileptic seizures and diagnostic work-up of the cardiovascular status, the patient was referred for neurosurgical treatment of the tumor formation.
我们报告了一例临床病例,一名70岁的女性因右半脸和右手的简单运动性癫痫发作而被紧急送入神经内科,并伴有威胁性癫痫持续状态。头部计算机断层扫描显示左后牙轴外钙化圆形结构,可能为脑膜瘤。入院时和症状发作期间,记录动态心电图变化,心前区T波呈阴性,血清肌钙蛋白动态增加。超声心动图显示左心室中段运动功能减退。在没有冠状动脉疾病证据的情况下进行冠状动脉造影。从心室造影中发现中段运动功能减退,测得EF为47%。启动了丙戊酸钠、地塞米松、甘露醇和氯硝西泮、左乙拉西坦、阿西他唑、他汀类药物和β受体阻滞剂的综合治疗。在控制了癫痫发作和心血管状态的诊断检查后,患者被转诊接受肿瘤形成的神经外科治疗。
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引用次数: 0
Basal pseudoaneurysm of the lateral wall of the left ventricle – case report 左心室外侧壁基底假性动脉瘤1例
Pub Date : 2022-12-31 DOI: 10.3897/bgcardio.28.e93503
R. Grigorov, P. Panayotov, D. Panayotova, I. Borisov
Left ventricle pseudoaneurysm is a rare but serious complication, most often secondary to myocardial infarction. It is associated with high mortality due to a significant risk of rupture. We present a case of a patient with a large basal pseudoaneurysm of the lateral wall of the left ventricle. The pseudoaneurysm is discovered from a chest radiography performed after a COVID-19 infection. The diagnosis is confirmed by echocardiography and ventriculography. The patient underwent surgical treatment by endoventricular patch plasty – Dor procedure. The patient in our case lacked the typical symptoms and ECG features, furthermore he had no history of myocardial infarction, cardiac surgery, trauma or endocarditis.
左心室假性动脉瘤是一种罕见但严重的并发症,通常继发于心肌梗死。由于严重的破裂风险,它与高死亡率相关。我们提出一个病例的病人与一个大的基底假性动脉瘤的左心室外壁。假性动脉瘤是在COVID-19感染后进行的胸片检查中发现的。超声心动图和心室造影证实了诊断。患者接受了室内补片成形术- Dor手术治疗。本例患者无典型症状和心电图特征,无心肌梗死史、心脏手术史、外伤史、心内膜炎史。
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引用次数: 0
Massive lipomatous hypertrophy of the interatrial septum and the wall of the right atrium mimicking a cardiac tumor (myxoma) 心房间隔和右心房壁大量脂肪瘤性肥大,形似心脏肿瘤(粘液瘤)。
Pub Date : 2022-12-31 DOI: 10.3897/bgcardio.28.e97871
R. Georgiev, S. Bakalska-Georgieva, A. Angelov
A patient was admitted to our institution with a diagnosis of a cardiac tumor, most likely myxoma, in the right atrium, detected at echocardiography. The cardio-magnetic resonance examination was performed and depicts a homogeneous fatty content, fatty proliferation and hypertrophy along the wall of the right atrium and the interatrial septum, sparing the oval fossa and mimicking a tumor with a filling defect and with slight compression of the inferior and superior vena cava. With the help of double and triple inversion techniques, magnetic resonance imaging can give a tissue-specific diagnosis, in this case a fat-equivalent lesion of the type of lipoma or lipomatous hypertrophy, and thus save additional studies and predetermine the therapeutic approach.
我们收治了一个病人,诊断为心脏肿瘤,很可能是黏液瘤,在右心房,超声心动图检测到。心脏磁共振检查显示,右心房和房间隔壁均质脂肪含量,脂肪增生和肥厚,保留卵圆窝,模拟肿瘤充盈缺损,下腔静脉和上腔静脉轻微受压。在双反转和三重反转技术的帮助下,磁共振成像可以给出组织特异性的诊断,在这种情况下是脂肪瘤或脂肪瘤性肥厚类型的脂肪等效病变,从而节省额外的研究并预先确定治疗方法。
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引用次数: 0
Infectious endocarditis – current profile 感染性心内膜炎——现状
Pub Date : 2022-12-31 DOI: 10.3897/bgcardio.28.e90366
B. Dobreva-Yatseva, F. Nikolov, R. Raycheva, M. Tokmakova
Infective endocarditis (IE) is a disease of the endocardium of the heart and the endocardium of the great vessels, with infection affecting heart valves (native or prosthetic) and subvalvular structures and, in the last few decades, indwelling intracardiac devices or catheters. It is a life-threatening disease with a wide distribution worldwide. IE was first described 350 years ago, but it continues to be a huge challenge for doctors for several reasons. First – IE is a changing disease. Nowadays, the profile of patients with IE has significantly changed in terms of age, predisposing factors, microbiological causative agent, clinical picture, complications, therapeutic approach. Second, despite modern imaging and microbiological methods, diagnostics often encounter serious difficulties and delays. Third, the improvement in medical and surgical treatment in recent decades has not changed the rates of mortality and severe complications. Knowing the current profile of patients with IE helps in timely and accurate diagnosis, which is key to starting adequate treatment. Early identification of high-risk patients is important for the therapeutic approach, especially when deciding on operative treatment. This is associated with a reduction in in-hospital mortality and an improvement in the long-term prognosis of patients.
感染性心内膜炎(IE)是一种心脏心内膜和大血管心内膜的疾病,感染会影响心脏瓣膜(天然或人工)和瓣下结构,在过去几十年中,还会影响心内留置装置或导管。它是一种危及生命的疾病,在世界范围内广泛分布。IE在350年前首次被描述,但由于几个原因,它对医生来说仍然是一个巨大的挑战。首先,IE是一种不断变化的疾病。目前,IE患者在年龄、易感因素、微生物病原体、临床表现、并发症、治疗方法等方面发生了显著变化。其次,尽管有现代成像和微生物学方法,但诊断往往会遇到严重的困难和延误。第三,近几十年来医疗和外科治疗的改善并没有改变死亡率和严重并发症。了解IE患者的当前情况有助于及时准确诊断,这是开始充分治疗的关键。早期识别高危患者对治疗方法很重要,尤其是在决定手术治疗时。这与降低住院死亡率和改善患者的长期预后有关。
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引用次数: 0
Aortic surgery in a patient with Marfan's syndrome and pectus excavatum (shoemaker's chest) Marfan综合征和漏斗胸(鞋匠胸)患者的主动脉手术
Pub Date : 2022-12-31 DOI: 10.3897/bgcardio.28.e96612
I. Todorov
Patients with Marfan syndrome often have severe life-threatening cardiovascular complications, including aortic aneurysmal dilatation or aortic dissection. Approximately two-thirds of people who have this syndrome suffer from chest wall deformities such as pectus excavatum (cobbler's chest) or pectus carinatum (bird's chest). When a patient with cobbler's chest requires aortic root surgery, the operator may face a major clinical challenge in selecting the optimal surgical access and approach. We present a case of a patient with Marfan syndrome and severe pectus excavatum who underwent aortic valve replacement, aortic root and ascending aorta reconstruction, coronary artery reimplantation (Bentall de Bono procedure ) via upper partial L-sternotomy and anterior left thoracotomy.
马凡综合征患者通常会出现严重的危及生命的心血管并发症,包括主动脉瘤扩张或主动脉夹层。大约三分之二的这种综合征患者患有胸壁畸形,如漏斗胸(皮匠胸)或隆突胸(鸟胸)。当皮匠胸患者需要进行主动脉根部手术时,操作员在选择最佳手术途径和方法方面可能面临重大临床挑战。我们报告了一例患有Marfan综合征和严重漏斗胸的患者,他们接受了主动脉瓣置换术、主动脉根和升主动脉重建术、冠状动脉重建术(Bentall-de-Bono手术),通过上部L切口和左前切口。
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引用次数: 0
Role of cardiac magnetic resonance imaging in the diagnosis of nonischemic cardiomyopathies 心脏磁共振成像在非缺血性心肌病诊断中的作用
Pub Date : 2022-12-30 DOI: 10.3897/bgcardio.28.e97338
A. Partenova, D. Kostova-Lefterova, K. Genova
In recent decades, cardiac magnetic resonance imaging (CMR) has been established  as a valuable tool in the diagnosis of patients with or at risk of heart failure. With its ability to characterize tissue changes in the myocardium, CMR can provide detailed and clinically useful information about the type and severity of cardiac damage. The method is not only important for differentiation of ischemic from non-ischemic cardiomyopathy, but also contributes to the correct diagnosis of non-ischemic cardiomyopathy subtypes. It is also widely accepted as a reference standard for the quantification of myocardial mass, volumes and ejection fraction. The purpose of this article is to review the role of CMR in the diagnosis and treatment of non-ischemic cardiomyopathies.
近几十年来,心脏磁共振成像(CMR)已被确定为诊断心力衰竭患者或有心力衰竭风险的患者的一种有价值的工具。CMR具有表征心肌组织变化的能力,可以提供有关心脏损伤类型和严重程度的详细和临床有用的信息。该方法不仅对区分缺血性心肌病和非缺血性心肌病很重要,而且有助于非缺血性心肌病亚型的正确诊断。它也被广泛接受为量化心肌质量、体积和射血分数的参考标准。本文旨在综述CMR在非缺血性心肌病诊断和治疗中的作用。
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引用次数: 0
期刊
B''lgarska kardiologiia
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