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T1 and T2 mapping – basic principles and clinical application T1、T2测图的基本原理及临床应用
Pub Date : 2022-12-30 DOI: 10.3897/bgcardio.28.e97285
K. Genova, D. Kostova-Lefterova
Cardiac magnetic resonance tomography is widely used method in the diagnosis of cardiovascular diseases. In the last decade, new techniques have been developed to obtain quantitative parameters of myocardial changes. T1 and T2 mapping are part of the routine CMRT protocol and allow direct quantification of T1 and T2 relaxation times in the myocardium as well as the calculation of extracellular volume. These are important biomarkers both for the diagnosis of various myocardial diseases and for monitoring treatment follow-up and determining prognosis. The purpose of this article is to provide a brief overview of the basic principles of the T1 and T2 mapping techniques, as well as their main applications in different types of cardiomyopathies.
心脏磁共振断层扫描是一种广泛应用于心血管疾病诊断的方法。在过去的十年中,新技术的发展,以获得定量参数的心肌变化。T1和T2制图是常规CMRT方案的一部分,可以直接量化心肌T1和T2的松弛时间,并计算细胞外体积。这些都是诊断各种心肌疾病、监测治疗随访和确定预后的重要生物标志物。本文旨在简要介绍T1和T2定位技术的基本原理,以及它们在不同类型心肌病中的主要应用。
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引用次数: 0
Cardiac magnetic resonance imaging in acute and chronic myocardial ischemia: current clinical application and future directions 心脏磁共振成像在急慢性心肌缺血中的临床应用现状及未来发展方向
Pub Date : 2022-12-30 DOI: 10.3897/bgcardio.28.e97466
M. Nedevska, V. Grudeva, A. Partenova
Ischemic heart disease, its sequelae and complications contribute substantially to morbidity and mortality worldwide. Significant technological progress in recent years has significantly expanded the application of non-invasive imaging modalities in the systematic and complex evaluation of patients with ischemic heart disease in the preclinical and clinically developed stages of the disease. Cardiac magnetic resonance imaging includes a complex morphological and functional assessment. Regional and global myocardial kinetics and function, morphological changes in myocardial tissue in the form of edema, hemorrhage, and scarring determine various manifestations of myocardial ischemia in its acute and chronic form. Currently established clinical protocols have already demonstrated their diagnostic and prognostic value. Under the influence of unceasing clinical interest, cardiac magnetic resonance imaging is constantly developing and improving with emerging imaging technologies that provide additional information based on advanced quantification of imaging biomarkers and improved diagnostic accuracy, therefore potentially allowing reduction or avoidance of contrast and/or stressor agents.
缺血性心脏病及其后遗症和并发症在全球范围内对发病率和死亡率起着重要作用。近年来的重大技术进步显著扩大了非侵入性成像模式在缺血性心脏病患者临床前和临床发展阶段的系统和复杂评估中的应用。心脏磁共振成像包括复杂的形态学和功能评估。局部和全局心肌动力学和功能、水肿、出血和瘢痕形成形式的心肌组织形态学变化决定了急性和慢性心肌缺血的各种表现。目前制定的临床方案已经证明了其诊断和预后价值。在不断的临床兴趣的影响下,心脏磁共振成像技术不断发展和改进,新兴的成像技术基于成像生物标志物的先进量化和提高的诊断准确性提供了额外的信息,因此有可能减少或避免造影剂和/或压力源。
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引用次数: 0
Тechnical aspects of cardiac magnetic resonance tomography Тechnical心脏磁共振断层扫描方面
Pub Date : 2022-12-30 DOI: 10.3897/bgcardio.28.e97065
D. Kostova-Lefterova, A. Partenova
Cardiac magnetic resonance tomography (CMRT) is a method of high diagnostic value in the assessment of cardiac vitality through the application of various perfusion techniques, as well as in the evaluation and diagnosis of early myocardial ischemic changes. The aim of this article is to review the different technical aspects of CMRT. A major problem in CMRT studies is the deterioration of image quality due to the presence of motion artefacts. This necessitates the development of ECG-gated and respiratory triggered or breath-holding techniques and their implementation in practice. In contrast to most other applications of MRT, the planes used in CMRT are defined with respect to the orientation of the heart so that they are parallel and orthogonal to the cardiac axes. Two main groups of sequences are used in CMRT: 1) to determine morphology, function, and blood flow and 2) to provide good tissue contrast of the heart. Technological development of the method has not stopped, and techniques and pulse sequences continue to be developed to improve the diagnostic capabilities of CMRT. Through proper planning, a thorough understanding of the cardiac planes, and appropriate selection of technical parameters for the respective sequences depending on the clinical finding being addressed, a successful performance of each CMRT study is achieved.
心脏磁共振断层扫描(CMRT)是一种通过应用各种灌注技术评估心脏活力以及评估和诊断早期心肌缺血变化的高诊断价值方法。本文的目的是回顾CMRT的不同技术方面。CMRT研究中的一个主要问题是由于运动伪影的存在而导致图像质量的恶化。这就需要开发心电图门控和呼吸触发或屏气技术及其在实践中的实施。与MRT的大多数其他应用不同,CMRT中使用的平面是相对于心脏的方向来定义的,使得它们平行于心脏轴并正交于心脏轴。CMRT中使用两组主要序列:1)确定形态、功能和血流;2)提供良好的心脏组织对比度。该方法的技术发展并没有停止,技术和脉冲序列仍在继续发展,以提高CMRT的诊断能力。通过适当的规划、对心脏平面的全面了解,以及根据所处理的临床发现为相应序列适当选择技术参数,实现了每项CMRT研究的成功实施。
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引用次数: 0
Cardiotoxicity during and after oncological treatment − role of cardio-magnetic resonance 肿瘤治疗期间和之后的心脏毒性-心脏磁共振的作用
Pub Date : 2022-12-30 DOI: 10.3897/bgcardio.28.e97523
R. Petkov, K. Genova
The purpose of this review article is to inform practicing cardiologists about the manifestations of cardiotoxicity in patients on or after antitumor therapy and about the potential of cardiac magnetic resonance imaging (CMR) in the diagnosis and follow-up of these patients. The definitions and classification of cardiotoxicity associated with antitumor treatment, the mechanisms of cardiac and vascular damage of some of the important groups of antitumor drugs, and the potential CMR findings are reviewed. The main clinical situations related to manifestations of cardiotoxicity in which CMR has or is expected to have a leading role are outlined.
这篇综述文章的目的是告知执业心脏病专家在接受或接受抗肿瘤治疗后患者的心脏毒性表现,以及心脏磁共振成像(CMR)在这些患者的诊断和随访中的潜力。本文综述了与抗肿瘤治疗相关的心脏毒性的定义和分类,一些重要的抗肿瘤药物对心脏和血管损伤的机制,以及潜在的CMR发现。本文概述了与CMR已经或有望发挥主导作用的心脏毒性表现相关的主要临床情况。
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引用次数: 0
Physical activity and cardiac rehabilitation in COVID-19 patients with cardiovascular complications 新冠肺炎心血管并发症患者的体力活动和心脏康复
Pub Date : 2022-09-30 DOI: 10.3897/bgcardio.28.e79418
Zheyna V. Cherneva, R. Cherneva
Recent data has revealed the cardiovascular complications of COVID-19 infection. The mechanism of cardiovascular impairments involves binding of severe acute respiratory syndrome (SARS) coronavirus-2 (CoV-2) to the protein angiotensin-converting enzyme 2 (ACE2), thus penetrating into the cells. There are other mechanisms, most of which are under research and will be explained. Cardiovascular complications of COVID-19 infection are heart failure, cardiomyopathy, acute coronary syndrome, arrhythmias, and venous thromboembolism. This article aims to collect scientific evidence by exploring PubMed, Scopus, and Pedro databases to show the cardiovascular complications of COVID-19 infection and the benefit of physiotherapy treatment for these patients. Exercise training is a powerful element in physiotherapy and an important part of cardiac rehabilitation. It contributes to significant changes of the cardiovascular system - recovery of endothelial dysfunction and prevention of thromboembolic complications. In conclusion, due to the wide variety of programs of exercise training, as well as patient monitoring, physical activity is appropriate strategy for the treatment of cardiovascular complications of various degrees in post-COVID patients. 
最近的数据揭示了新冠肺炎感染的心血管并发症。心血管损伤的机制包括严重急性呼吸综合征(SARS)冠状病毒2型(CoV-2)与蛋白质血管紧张素转化酶2(ACE2)的结合,从而渗透到细胞中。还有其他机制,其中大部分正在研究中,并将予以解释。新冠肺炎感染的心血管并发症包括心力衰竭、心肌病、急性冠状动脉综合征、心律失常和静脉血栓栓塞。本文旨在通过探索PubMed、Scopus和Pedro数据库来收集科学证据,以显示新冠肺炎感染的心血管并发症以及物理治疗对这些患者的益处。运动训练是物理治疗中的一个强大元素,也是心脏康复的重要组成部分。它有助于心血管系统的显著变化——恢复内皮功能障碍和预防血栓栓塞并发症。总之,由于运动训练和患者监测的项目种类繁多,体育活动是治疗新冠肺炎后患者不同程度心血管并发症的合适策略。
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引用次数: 0
Endovascular treatment of type „A“ and type „B“ dissection of the aorta A型和B型主动脉夹层的血管内治疗
Pub Date : 2022-09-30 DOI: 10.3897/bgcardio.28.e89568
Z. Stankov, I. Petrov, D. Boychev
During the period from March 2014 to May 2018, endovascular treatment of aortic dissection type A and type B was carried out in a total of 70 patients. Patients were divided into two groups, aortic dissection type A (14 patients) and type B (56 patients), a group-by-group descriptive analysis was conducted, and then a comparison was done between the two patient groups.  The aim of the study was to establish the effective use of endovascular treatment in type A and type B aorta dissection. As a result of the survey, data on the demographic characteristics and risk profile of these patients are accumulated for the first time in Bulgaria. Endovascular treatment options for the treatment of aortic dissection type A and type B, as well as malperfusion syndrome, are examined, demonstrating their effectiveness and safety. As a result of the study, it is proven that endovascular treatment in aortic dissection type A and type B leads to a significant increase in the size of the true lumen and reduction of the false lumen, which leads to an improvement in perfusion and reduces the risk of developing an aneurysm and rupture.  The presence of endoleak and persistent communication between the false and the real lumen are the most common causes of re-intervention, such as endovascular options are most often the first line for their dealing and are proven to be effective and safe.  Treatment of dissection of the aorta type A and B is not a one-time act, but requires periodic diagnostic control and, if necessary, surfery and/or endovascular corrections of the complications that have arisen.
2014年3月至2018年5月,共对70例A型和B型主动脉夹层患者进行了血管内治疗。将患者分为A型(14例)和B型(56例)两组,逐组进行描述性分析,并对两组患者进行比较。本研究的目的是建立血管内治疗在A型和B型主动脉夹层中的有效应用。调查的结果是,保加利亚首次积累了关于这些患者的人口特征和风险概况的数据。对A型和B型主动脉夹层以及灌注不良综合征的血管内治疗方案进行了检查,证明了其有效性和安全性。研究结果证明,a型和B型主动脉夹层的血管内治疗导致真腔的大小明显增加,假腔的减少,从而改善灌注,降低动脉瘤发生和破裂的风险。内漏的存在和假腔与真腔之间的持续通信是再次干预的最常见原因,例如血管内选择通常是治疗的第一线,并且被证明是有效和安全的。A型和B型主动脉夹层的治疗不是一次性的,而是需要定期的诊断控制,必要时,对已出现的并发症进行手术和/或血管内矫正。
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引用次数: 0
Eye lens dose assessment in interventional cardiology 介入心脏病学中的晶状体剂量评估
Pub Date : 2022-09-30 DOI: 10.3897/bgcardio.28.e89578
A. Zagorska, V. Gelev, I. Jeleva, N. Stoyanov, D. Ivanova
Introduction: Medical professionals performing fluoroscopy guided interventional procedures in cardiology are exposed to a risk of radiation induced cataract, especially if the eye lens dose exceeds the annual dose limit of 20 mSv. Aim: The aim of the current study is to measure the eye lens exposure in three interventional cardiology departments, to analyze the relationship between patient dose and eye lens dose and to study the effectiveness of lead goggles without side protection. Material and methods: Measurements were performed in three departments with participation of 4 interventional cardiologists and 6 nurses. The exposure of the eye lens was measured with EYE-DTM (Radcard) passive dosimeters. Results: For nurses the annual eye lens dose varied from 1.6 mSv to 4.3 mSv. For the interventional cardiologists the results were between 3.2 mSv and 31.4 mSv. The dose reduction factor of the studied safety goggles without side protection is 1 and 1.1. Conclusions: There is a risk of exceeding the annual exposure limit of 20 mSv among interventional cardiologists The eye lens exposure depends on the workload and the clinical complexity of the procedures, as well as on the use of radiation protection devices. Due to the specifics of the procedures, the use of goggles with side protection is recommended. The eye lens dose for nurses is lower than the annual limit, which can be explained with the larger distance between the patient and the nurses and partial shielding by the main operator. Lead glasses without side shielding are not recommended because the exposure occurs from the side.
导读:在心脏病学中进行透视引导介入手术的医疗专业人员面临着辐射诱发白内障的风险,特别是当眼晶状体剂量超过20毫西弗的年剂量限制时。目的:本研究的目的是测量三个介入心内科的眼晶状体暴露情况,分析患者剂量与眼晶状体剂量的关系,研究无侧护铅护目镜的有效性。材料和方法:在3个科室进行测量,4名介入心脏科医师和6名护士参与。采用eye - dtm (Radcard)被动剂量计测定眼球晶状体暴露。结果:护理人员晶状体年剂量为1.6 ~ 4.3毫西弗。对于介入心脏病专家,结果在3.2毫西弗到31.4毫西弗之间。所研究的无侧护护目镜的剂量减小系数分别为1和1.1。结论:介入心脏病专家存在超过20毫西弗的年暴露限值的风险。眼晶状体暴露取决于工作量和临床手术的复杂性,以及辐射防护装置的使用。由于手术的特殊性,建议使用带侧面保护的护目镜。护理人员的晶状体剂量低于年度限定剂量,这可能与患者与护理人员的距离较大以及主要操作人员的部分遮挡有关。不建议使用没有侧面屏蔽的铅玻璃,因为暴露是从侧面发生的。
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引用次数: 0
Thrombophilia in Budd-Chiari syndrome patient Budd-Chiari综合征患者的血栓形成倾向
Pub Date : 2022-09-30 DOI: 10.3897/bgcardio.28.e89444
V. Dimitrova, I. Petrov, N. Zlatareva
A 27-years old female patient presented with a severe general condition of generalized edema and hypotension. Two months earlier computed tomography imaged thrombosis of the inferior vena cava and the three hepatic veins, or Budd-Chiari syndrome (BCS). Additional findings were thrombosis of the right common iliac vein and thrombosis of the renal veins bilaterally. Genetic testing proved congenital thrombophilia. Anticoagulation therapy did not affect thrombotic occlusions. In another cardiovascular center, an unsuccessful attempt for interventional treatment of the inferior vena cava with a jugular approach was made. The patient was admitted to our hospital for further evaluation and decision on treatment strategy. Laboratory and non-invasive imaging at admission rejected hepatic cirrhosis. An abdominal ultrasound scan demonstrated complete occlusion of the three hepatic veins and post hepatic portal hypertension. When thrombosis of all hepatic veins was detected transjugular intrahepatic portosystemic shunt (TIPS) was an option. An endovascular strategy for inferior vena cava was undertaken and complete revascularization was achieved with the right femoral approach as a bridge to TIPS shunt procedure, since the patient didn’t meet the criteria for liver transplantation. In diagnosing disease, the main contributors were the gastroenterologist, diagnostic imaging specialist, and hematologist, while the multidisciplinary team included also cardiologist, interventional cardiologist, and angiologist. In this case the multidisciplinary decisions played a major role in diagnosing and building an appropriate therapeutic strategy for systemic illnesses and conditions for which medical guidance does not yet have clear guidelines.
一名27岁的女性患者表现为严重的全身性水肿和低血压。两个月前,计算机断层扫描成像了下腔静脉和三条肝静脉的血栓形成,即布-加综合征(BCS)。其他发现是右侧髂总静脉血栓形成和双侧肾静脉血栓形成。基因检测证实了先天性血栓形成倾向。抗凝治疗不影响血栓闭塞。在另一个心血管中心,颈静脉入路介入治疗下腔静脉的尝试失败了。患者入院接受进一步评估并决定治疗策略。入院时的实验室和非侵入性成像拒绝肝硬化。腹部超声扫描显示三条肝静脉完全闭塞,肝后门静脉高压。当检测到所有肝静脉血栓形成时,经颈静脉肝内门体分流术(TIPS)是一种选择。由于患者不符合肝移植的标准,因此采取了下腔静脉血管内策略,并通过右股动脉入路作为TIPS分流程序的桥梁实现了完全的血运重建。在诊断疾病方面,主要贡献者是胃肠病学家、诊断成像专家和血液学家,而多学科团队还包括心脏病专家、介入心脏病专家和血管学家。在这种情况下,多学科决策在诊断和制定适当的治疗策略方面发挥了重要作用,以治疗医疗指导尚未明确的系统性疾病和病症。
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引用次数: 0
Infrared thermography imaging as a diagnostic tool in the case of acute lower limb ischemia 红外热成像作为诊断急性下肢缺血的工具
Pub Date : 2022-09-30 DOI: 10.3897/bgcardio.28.e91048
S. Vasilev, I. Petrov, Z. Stankov, L. Janevska, G. Adam
Atherosclerosis is the major cause of cardiovascular diseases (CVD) in the world. It is a multifocal disease that leads to plaque formation and subsequent ischemia in the arteries of the body. Atherosclerotic obstructive peripheral artery disease causes disturbance of blood delivery to the tissues, which can be translated as temperature decrease on the skin surface, making surface temperature an important indicator of vascular health. Even though there are many classical diagnostic tools for assessing patients with peripheral vascular dysfunction, they have many limitations. On the other hand, infrared thermography imaging presents a noninvasive, relatively cheap, quick and reliable method that does not require direct doctor-to-patient contact. It provides a real time screening information of the tissue perfusion, based on the skin surface temperature. In this article, we present a case of a patient with type B aortic dissection, treated with an endovascular approach. A postprocedural closure device complication led to an acute left lower limb ischemia during the night, which was promptly diagnosed with the help of an onsite high-resolution infrared thermography optimized by specialized AI based software performed by the physician on duty followed by remote evaluation by the operator. The obstruction was treated immediately with successful endovascular recanalization and flow restoration and again evaluated with the thermographic camera confirming excellent tissue vascular result. Infrared thermography imaging can be a time-saving method for physicians, while being a very convenient method for the patient and that is why we advocate on the usage of specialized software supported high resolution thermography imaging as a supplementary diagnostic modality for patients with peripheral artery disease.
动脉粥样硬化是世界上心血管疾病的主要原因。它是一种多灶性疾病,会导致斑块形成和随后的身体动脉缺血。动脉粥样硬化性阻塞性外周动脉疾病会导致血液输送到组织的紊乱,这可以转化为皮肤表面的温度下降,使表面温度成为血管健康的重要指标。尽管有许多经典的诊断工具用于评估外周血管功能障碍患者,但它们有许多局限性。另一方面,红外热成像提供了一种无创、相对便宜、快速可靠的方法,不需要医生与患者直接接触。它提供了基于皮肤表面温度的组织灌注的实时筛选信息。在这篇文章中,我们介绍了一例B型主动脉夹层患者,采用血管内入路治疗。术后闭合装置并发症导致夜间急性左下肢缺血,在值班医生执行的基于人工智能的专用软件优化的现场高分辨率红外热像图的帮助下,操作员进行远程评估,及时诊断出该情况。梗阻立即得到治疗,血管内再通和血流恢复成功,并再次用热像仪进行评估,证实了良好的组织血管结果。红外热成像对医生来说是一种节省时间的方法,同时对患者来说也是一种非常方便的方法,这就是为什么我们提倡使用专业软件支持的高分辨率热成像作为外周动脉疾病患者的辅助诊断模式。
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引用次数: 1
Renal denervation in clinical practice: treating patients with high cardiovascular risk 临床应用肾去神经支配治疗心血管高危患者
Pub Date : 2022-09-30 DOI: 10.3897/bgcardio.28.e93484
I. Petrov, Z. Stankov, J. Stoykova, S. Vasilev
Introduction: Arterial hypertension is the most common correctable risk factor for death worldwide. Achievement of therapeutic goal is hampered by multiple factors including non-adherence to drug therapy and individual physiological resistance. Objective: We aimed to determine the efficacy of renal denervation in lowering SBP and DBP at 1st and 6th month, in patients at high cardiovascular risk, in whom lowering BP would possibly also result in risk reduction and lower incidence of future cardiovascular events. Methods: The procedure was performed in 39 patients with resistant hypertension admitted to the University Hospital „Acibadem City Clinic – Cardiovascular Center“ (Sofia) for the period January 2017–June 2020. Access was via brachial artery and the Simplicity Spiral catheters were used, at an average of 19.5 ablation points per artery. The number of complications, as well as the mean systolic and diastolic BP values at 1st and 6th month were recorded. Baseline, risk profile and follow-up medical treatment of the study group was monitored. Results: In the study group, the predominant risk factors were dyslipidemia, age, diabetes mellitus, with 21 patients (53.84%) already having clinically significant atherosclerosis – a realized heart attack, stroke, peripheral or coronary revascularization. At follow-up, a significant reduction in both systolic and diastolic BP (blood pressure) values was observed. At the first month, the fall in SBP (systolic blood pressure) was –17.8 mm Hg, with a persistent reduction in the range of –14.5 mm Hg at 6th month. In terms of DBP (diastolic BP), the mean reduction at the first month was –8.9 mm Hg and at the 6th month it was –7.2 mm Hg. Regarding antihypertensive treatment, there was a mild reduction in the intake of antihypertensive drugs. Conclusion: Substantial proportion of people with hypertension have uncontrolled hypertension (both treatment resistant and due to non-adherence to treatment or due to additional pathophysiological mechanisms). Renal denervation has proven effective and safe in patients with uncontrolled hypertension and high cardiovascular risk profile
引言:动脉性高血压是世界范围内最常见的可纠正的死亡危险因素。治疗目标的实现受到多种因素的阻碍,包括不坚持药物治疗和个体生理抵抗。目的:我们旨在确定去肾神经在心血管高危患者第1个月和第6个月降低收缩压和舒张压的疗效,在这些患者中,降低血压也可能降低风险和降低未来心血管事件的发生率。方法:对2017年1月至2020年6月期间入住索菲亚大学医院“Acibadem市诊所-心血管中心”的39名顽固性高血压患者进行该手术。通过肱动脉进入,使用Simplicity Spiral导管,平均每条动脉19.5个消融点。记录并发症的数量,以及第1个月和第6个月的平均收缩压和舒张压值。对研究组的基线、风险状况和后续医疗进行监测。结果:在研究组中,主要的风险因素是血脂异常、年龄、糖尿病,21名患者(53.84%)已经患有临床上显著的动脉粥样硬化——实现了心脏病发作、中风、外周血运重建或冠状动脉血运重建。在随访中,观察到收缩压和舒张压均显著降低。在第一个月,收缩压(SBP)的下降幅度为-17.8毫米汞柱,第6个月持续下降幅度为-14.5毫米汞柱。就舒张压而言,第一个月的平均下降量为-8.9毫米汞柱,第六个月为-7.2毫米汞柱。关于抗高血压治疗,抗高血压药物的摄入量略有减少。结论:相当一部分高血压患者的高血压未得到控制(既有治疗耐药性,也有由于不坚持治疗或其他病理生理机制)。肾去神经支配已被证明对高血压失控和心血管风险高的患者有效且安全
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引用次数: 0
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B''lgarska kardiologiia
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