Dyah Pitaloka, Nurus Safa’ah, Linda Yuni Alfiyanti
Background: The phenomenon of the risk of falling that occurs in the elderly in recent years has increased. Many cases of falls in the elderly result in soft tissue injuries, thigh and wrist fractures, and even death. Falling is a physical problem that is often experienced by the elderly, as you get older, the higher the decline in physical, mental and bodily functions.Objective: To Analyze the effect of the otago home exercise programme on decreasing the level of falling risk in the elderly in Tegalrejo Village, Merakurak District.Methods:The research used pra-experimental: pra-pasca test (one group pra-post design) with a cohort approach. The Sampling technique used was purposive sampling with a total sample of 102 elderly.Results: The results of the research conducted after being analyzed using the wilcoxon test with a significance level of α=<0.05, with value p = 0,000<0,05 value results Asymp sig(2-tailed)=0,000 which shows the influence between the two variables into a strong category with a positive direction.Conclusion: Otago home exercise programme has an effect on decreasing the level of falling risk in the elderly in Tegalrejo Village, Merakurak District.
{"title":"The Effect of the Otago Home Exercise Programme on Decreasing the Level of Falling Risk in the Elderly in Tegalrejo Village, Merakurak District","authors":"Dyah Pitaloka, Nurus Safa’ah, Linda Yuni Alfiyanti","doi":"10.30989/mik.v12i2.891","DOIUrl":"https://doi.org/10.30989/mik.v12i2.891","url":null,"abstract":"Background: The phenomenon of the risk of falling that occurs in the elderly in recent years has increased. Many cases of falls in the elderly result in soft tissue injuries, thigh and wrist fractures, and even death. Falling is a physical problem that is often experienced by the elderly, as you get older, the higher the decline in physical, mental and bodily functions.Objective: To Analyze the effect of the otago home exercise programme on decreasing the level of falling risk in the elderly in Tegalrejo Village, Merakurak District.Methods:The research used pra-experimental: pra-pasca test (one group pra-post design) with a cohort approach. The Sampling technique used was purposive sampling with a total sample of 102 elderly.Results: The results of the research conducted after being analyzed using the wilcoxon test with a significance level of α=<0.05, with value p = 0,000<0,05 value results Asymp sig(2-tailed)=0,000 which shows the influence between the two variables into a strong category with a positive direction.Conclusion: Otago home exercise programme has an effect on decreasing the level of falling risk in the elderly in Tegalrejo Village, Merakurak District.","PeriodicalId":340508,"journal":{"name":"MEDIA ILMU KESEHATAN","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135737307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zakiyyah Qurrotul Aini, Wiwin Herdwiani, Tri Wijayanti
Background: Diabetes Mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. Diabetic nephropathy is a degenerative kidney vascular disorder that has a relationship with impaired carbohydrate metabolism or sugar intolerance (Diabetes Mellitus). Black turmeric (Curcuma Caesia Roxb.) is widely used by the community as a traditional medicine and has potential as an antidiabetic.Objective: This study aims to determine the effect of black turmeric extract on decreasing blood glucose levels and its effect on improving kidney histopathology in diabetic nephropathy rats.Method: This research was conducted at the Laboratory of the Center for Food and Nutrition Studies, University of Gajah Mada for the period October-November 2022 consisting of 6 groups. STZ-Na induced rats to obtain a state of hyperglycemia. Examination of blood glucose levels using the GOD-PAP method (enzymatic photometric test).Results: The percentage of blood glucose is decreased levels was 16.75% and repaired kidney histopathology was 6.67% as a score mild damage category (1).Conclusion: Black turmeric rhizome extract (Curcuma Caesia Roxb.) can reduce blood glucose levels and improve kidney function at a dose of 400 mg/kg BW.
{"title":"Efektivitas rimpang kunyit hitam (curcuma caesia roxb.) Terhadap penurunan glukosa darah dan perbaikan ginjal tikus diabetes nefropati","authors":"Zakiyyah Qurrotul Aini, Wiwin Herdwiani, Tri Wijayanti","doi":"10.30989/mik.v12i2.874","DOIUrl":"https://doi.org/10.30989/mik.v12i2.874","url":null,"abstract":"Background: Diabetes Mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. Diabetic nephropathy is a degenerative kidney vascular disorder that has a relationship with impaired carbohydrate metabolism or sugar intolerance (Diabetes Mellitus). Black turmeric (Curcuma Caesia Roxb.) is widely used by the community as a traditional medicine and has potential as an antidiabetic.Objective: This study aims to determine the effect of black turmeric extract on decreasing blood glucose levels and its effect on improving kidney histopathology in diabetic nephropathy rats.Method: This research was conducted at the Laboratory of the Center for Food and Nutrition Studies, University of Gajah Mada for the period October-November 2022 consisting of 6 groups. STZ-Na induced rats to obtain a state of hyperglycemia. Examination of blood glucose levels using the GOD-PAP method (enzymatic photometric test).Results: The percentage of blood glucose is decreased levels was 16.75% and repaired kidney histopathology was 6.67% as a score mild damage category (1).Conclusion: Black turmeric rhizome extract (Curcuma Caesia Roxb.) can reduce blood glucose levels and improve kidney function at a dose of 400 mg/kg BW.","PeriodicalId":340508,"journal":{"name":"MEDIA ILMU KESEHATAN","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135737309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: One of the government's efforts to increase the coverage of deliveries in health facilities is by establishing a maternity waiting home (MWH)Objective: This study aims to evaluate the implementation of the MWHs Program in the Depapre district and Unurum Guay, Jayapura district, Papua. The component of study including the input component, process, output and external factor Method: Type of this research is qualitative research, evaluate the program using the Logic model conducted in MWHs Jayapura district. The research subjects included 9 program managers, and 28 people in community.. Data collection performed with interviews, observation, questionnaires and document analysisResults: The results indicate that the input component includes the availability of funding, policies, facilities infrastructure, and inadequate transportation which has impact for MWHs service process. Process of implementation of MWHs in form of disseminating information, cooperation, recording, reporting and supervision has not optimal. The output component form of MWHs utilization already well even though in the following year there was a decrease Conclusion: The implementation of the MWHs program is not optimal. The input component is still inadequate, the process component has not run optimally and the output component has not achieved the expected results. Strategy is needed for program implementation runs a well
{"title":"Evaluasi pelaksanaan program rumah tunggu kelahiran (RTK) dengan logic model di Kabupaten Jayapura Provinsi Papua","authors":"Vera Iriani Abdullah, Wiwit Vitania","doi":"10.30989/mik.v11i3.795","DOIUrl":"https://doi.org/10.30989/mik.v11i3.795","url":null,"abstract":"Background: One of the government's efforts to increase the coverage of deliveries in health facilities is by establishing a maternity waiting home (MWH)Objective: This study aims to evaluate the implementation of the MWHs Program in the Depapre district and Unurum Guay, Jayapura district, Papua. The component of study including the input component, process, output and external factor Method: Type of this research is qualitative research, evaluate the program using the Logic model conducted in MWHs Jayapura district. The research subjects included 9 program managers, and 28 people in community.. Data collection performed with interviews, observation, questionnaires and document analysisResults: The results indicate that the input component includes the availability of funding, policies, facilities infrastructure, and inadequate transportation which has impact for MWHs service process. Process of implementation of MWHs in form of disseminating information, cooperation, recording, reporting and supervision has not optimal. The output component form of MWHs utilization already well even though in the following year there was a decrease Conclusion: The implementation of the MWHs program is not optimal. The input component is still inadequate, the process component has not run optimally and the output component has not achieved the expected results. Strategy is needed for program implementation runs a well","PeriodicalId":340508,"journal":{"name":"MEDIA ILMU KESEHATAN","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135287211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The problem of medical hazardous and toxic materials waste management is still often the problem of mostly being in hospitals plus during the COVID-19 pandemic. Objective: The study aimed to evaluate the management of medical hazardous and toxic materials waste at Diponegoro National Hospital, Semarang city during the COVID-19 pandemic.Methods: Data collection was carried out through qualitative descriptions.Results: Management that has not been in accordance with regulations was waste bags that were still found that have not been equipped with infectious symbols, the binding to garbage bags was not correct, and the bags were still hollow. There was still a discrepancy in the waste storage at the TPS, namely the floor of the TPS looks dirty. Selection of special lines for transportation, provision of disinfectants and noncompliance with the use of Personal Protective Equipment (PPE) for waste officers.Conclusion: It is recommended that the Hospital has made efforts to meet the standard requirements for waste management in accordance with the Minister of Environment and Forestry Regulation No. 56 of 2015
{"title":"Hazardous and toxic waste management operations in educational hospitals Semarang city","authors":"Nandya Silvalinda, Ayun Sriatmi, Nurhasmadiar Nandini","doi":"10.30989/mik.v11i3.842","DOIUrl":"https://doi.org/10.30989/mik.v11i3.842","url":null,"abstract":"Background: The problem of medical hazardous and toxic materials waste management is still often the problem of mostly being in hospitals plus during the COVID-19 pandemic. Objective: The study aimed to evaluate the management of medical hazardous and toxic materials waste at Diponegoro National Hospital, Semarang city during the COVID-19 pandemic.Methods: Data collection was carried out through qualitative descriptions.Results: Management that has not been in accordance with regulations was waste bags that were still found that have not been equipped with infectious symbols, the binding to garbage bags was not correct, and the bags were still hollow. There was still a discrepancy in the waste storage at the TPS, namely the floor of the TPS looks dirty. Selection of special lines for transportation, provision of disinfectants and noncompliance with the use of Personal Protective Equipment (PPE) for waste officers.Conclusion: It is recommended that the Hospital has made efforts to meet the standard requirements for waste management in accordance with the Minister of Environment and Forestry Regulation No. 56 of 2015","PeriodicalId":340508,"journal":{"name":"MEDIA ILMU KESEHATAN","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135287213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Food safety in the community is relatively low. This is evidenced by the fact that many food products contain harmful substances, such as the discovery of formalin anchovy salted fish in the city of Yogyakarta. This condition can threaten the health of the people of Yogyakarta City because many traders use anchovies as the main raw material in their cooking, such as in the manufacture of Angkringan Cat Rice, the typical cuisine of the city of Yogyakarta. This potential hazard can be suppressed by reducing the level of formalin that may be contained in anchovy before consumption, one of which is by utilizing the saponin content in garlic peel waste.
Objective: This study aims to study the effect of the mass of garlic peel waste powder on formalin in salted anchovy samples
Methods: The type of this research was a completely randomized design (CRD) with ten mass variations of garlic peel waste powder, namely 0, 1, 2, 3, 4, 5, 6, 7, 8, and 10 grams of powder in 50 ml of distilled water. This design is used to soak 1 gram of anchovy with formalin for 30 minutes at room temperature. Sampling was done by accidental sampling method at five traditional markets in Yogyakarta City. Formalin identification was carried out using the ET Group brand formalin test kit. Samples that have been treated are then re-determined the levels of formalin. Determination of formalin content was carried out by the acidimetric method. The effect test was carried out statistically with a confidence level of 0.05.
Results: The highest decrease in formalin levels in the F7 treatment (soaking 1 gram of anchovy salted fish in 6 grams of garlic peel powder in 50 ml of distilled water for 30 minutes) reached 89.12%. However, with the addition of more powder (F8-10), it was seen that there was a decrease in the reduction ability of formalin by saponins. The statistical test showed that the mass of garlic peel waste powder affected reducing the level of formalin in anchovy salted fish (sig < 0.05).
Conclusion: Garlic peel waste powder has the potential to reduce formalin levels in anchovy salted fish
{"title":"Reduction Potential of Formalin in Salted Fish Anchovy by Garlic Peel Waste Powder","authors":"Amelia Handayani Burhan","doi":"10.30989/mik.v11i3.783","DOIUrl":"https://doi.org/10.30989/mik.v11i3.783","url":null,"abstract":"Background: Food safety in the community is relatively low. This is evidenced by the fact that many food products contain harmful substances, such as the discovery of formalin anchovy salted fish in the city of Yogyakarta. This condition can threaten the health of the people of Yogyakarta City because many traders use anchovies as the main raw material in their cooking, such as in the manufacture of Angkringan Cat Rice, the typical cuisine of the city of Yogyakarta. This potential hazard can be suppressed by reducing the level of formalin that may be contained in anchovy before consumption, one of which is by utilizing the saponin content in garlic peel waste.
 Objective: This study aims to study the effect of the mass of garlic peel waste powder on formalin in salted anchovy samples
 Methods: The type of this research was a completely randomized design (CRD) with ten mass variations of garlic peel waste powder, namely 0, 1, 2, 3, 4, 5, 6, 7, 8, and 10 grams of powder in 50 ml of distilled water. This design is used to soak 1 gram of anchovy with formalin for 30 minutes at room temperature. Sampling was done by accidental sampling method at five traditional markets in Yogyakarta City. Formalin identification was carried out using the ET Group brand formalin test kit. Samples that have been treated are then re-determined the levels of formalin. Determination of formalin content was carried out by the acidimetric method. The effect test was carried out statistically with a confidence level of 0.05.
 Results: The highest decrease in formalin levels in the F7 treatment (soaking 1 gram of anchovy salted fish in 6 grams of garlic peel powder in 50 ml of distilled water for 30 minutes) reached 89.12%. However, with the addition of more powder (F8-10), it was seen that there was a decrease in the reduction ability of formalin by saponins. The statistical test showed that the mass of garlic peel waste powder affected reducing the level of formalin in anchovy salted fish (sig < 0.05).
 Conclusion: Garlic peel waste powder has the potential to reduce formalin levels in anchovy salted fish","PeriodicalId":340508,"journal":{"name":"MEDIA ILMU KESEHATAN","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135287493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ignasia Nila Siwi, Annisa Aina Fitria, Tri Hardi Miftahul Ulum
Background: Hypertension is a non-communicable disease that is one of the causes of mortality in the world. Hypertension is often referred to as the silent killer because it is often without complaints, a serious condition that significantly increases the risk of heart, brain, kidney, and other diseases. Complications in patients with hypertension can be life-threatening, so pharmacological therapies is wet cupping which can lower blood pressure. Objective: The purpose of this study was to determine the effect of wet cupping on hypertension. Methods: The method in this study uses the PICOS framework, namely Population/problem (P), Intervention (I), Comparison (C), Outcome (O), and study design (S). In the early stages of article selection, 68 articles were found from the PubMed database, ProQuest, Elsevier, Science Direct, Google Scholar, Harvard Library, Springer Link, ResearchGate, Taylor and Francis search engine after further matching, 60 article were selected, then 53 articles were excluded because they were not appropritate. With problems, intervention, study design, and no effect of wet cupping on hypertension so that 7 articles were obtained that matched the research topic. Results: The results of the search that wet cupping affects hypertension, this is evidenced from before and after the wet cupping intervention was given, namely there was a significant decrease in systole and diastole with p-value <0,05. This wet cupping treatment is more effective, given once a month for satisfactory results with an adminstration time of 15-30 minutes.Conclusion: This treatment is highly recommended to the general public, health clinics, hospitals, and health workers and this treatment provides many benefits.
{"title":"Literature review pengaruh pemberian bekam basah terhadap hipertensi","authors":"Ignasia Nila Siwi, Annisa Aina Fitria, Tri Hardi Miftahul Ulum","doi":"10.30989/mik.v11i3.753","DOIUrl":"https://doi.org/10.30989/mik.v11i3.753","url":null,"abstract":"Background: Hypertension is a non-communicable disease that is one of the causes of mortality in the world. Hypertension is often referred to as the silent killer because it is often without complaints, a serious condition that significantly increases the risk of heart, brain, kidney, and other diseases. Complications in patients with hypertension can be life-threatening, so pharmacological therapies is wet cupping which can lower blood pressure. Objective: The purpose of this study was to determine the effect of wet cupping on hypertension. Methods: The method in this study uses the PICOS framework, namely Population/problem (P), Intervention (I), Comparison (C), Outcome (O), and study design (S). In the early stages of article selection, 68 articles were found from the PubMed database, ProQuest, Elsevier, Science Direct, Google Scholar, Harvard Library, Springer Link, ResearchGate, Taylor and Francis search engine after further matching, 60 article were selected, then 53 articles were excluded because they were not appropritate. With problems, intervention, study design, and no effect of wet cupping on hypertension so that 7 articles were obtained that matched the research topic. Results: The results of the search that wet cupping affects hypertension, this is evidenced from before and after the wet cupping intervention was given, namely there was a significant decrease in systole and diastole with p-value <0,05. This wet cupping treatment is more effective, given once a month for satisfactory results with an adminstration time of 15-30 minutes.Conclusion: This treatment is highly recommended to the general public, health clinics, hospitals, and health workers and this treatment provides many benefits.","PeriodicalId":340508,"journal":{"name":"MEDIA ILMU KESEHATAN","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135287212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: One of the common adolescent problems is anemia. Knowledge is one of the factors that influence of anemia. One of the media that increase knowledge is educational media based on android. educational media based on android is more interesting than the other media. Adolescent is the most group of internet and android users among the other age groups.Objective: This research aim to know the effectiviness educational media based on android. Methods: The research was conducted by Quasy experimental with control group post-test design method which consisted of 2 groups, namely the intervention group that was given intervention by educational media based on android which created by a mock up system and the control group was given vide . The sample was 110 each group with purposive sampling. the data was analyzed by Stata 13.1 with mann whitney test.Results: Based on the results of statistical tests, it is known that there is a difference between intervention and the control group (p value <0.05). the average score of knowledge in the intervention group was 83.15 and the control group was 77.1. Conclusion: Android-based educational media has effect to increase the knowledge of anemia in adolescents
{"title":"Media edukasi berbasis android untuk meningkatkan pengetahuan tentang anemia pada remaja","authors":"None Lulu Luthfiya, Aghitsna Fyrodhika, Kartika Pibriyanti, Fathimah Fathimah","doi":"10.30989/mik.v11i3.797","DOIUrl":"https://doi.org/10.30989/mik.v11i3.797","url":null,"abstract":"Background: One of the common adolescent problems is anemia. Knowledge is one of the factors that influence of anemia. One of the media that increase knowledge is educational media based on android. educational media based on android is more interesting than the other media. Adolescent is the most group of internet and android users among the other age groups.Objective: This research aim to know the effectiviness educational media based on android. Methods: The research was conducted by Quasy experimental with control group post-test design method which consisted of 2 groups, namely the intervention group that was given intervention by educational media based on android which created by a mock up system and the control group was given vide . The sample was 110 each group with purposive sampling. the data was analyzed by Stata 13.1 with mann whitney test.Results: Based on the results of statistical tests, it is known that there is a difference between intervention and the control group (p value <0.05). the average score of knowledge in the intervention group was 83.15 and the control group was 77.1. Conclusion: Android-based educational media has effect to increase the knowledge of anemia in adolescents","PeriodicalId":340508,"journal":{"name":"MEDIA ILMU KESEHATAN","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135287215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Pigment is a dye derived from the mold of Monascus sp which is known to have antiviral activity, hepatitis B is an inflammation of the liver organs caused by the hepatitis B virus. Objective: This study aims to find out whether the five pigments of Monascus sp derivative compounds have the potential to be inhibitors of hepatitis BMethods: The method used in this study is molecular docking, with hepatitis B virus protein samples with the PDB code 5GMZ to be used as docking targets. Results: The results of docking showed that monascin compounds had the best inhibitor activity with energy binding of -7.96 kcal / mol and an inhibition constant of 1.46 uM, the formation of hydrogen and hydropobic bonds.The results of the RMSD chart from MD showed that the Monascin compound was stable at the beginning of the simulation with an average RMSD of 2.1 Å, on the RMSF chart it showed the lowest fluctuation when the compound bound to the amino acid PHE103.Conclusion: Of the five test ligands used, the potential as an inhibitor of hepatitis B is the compound Monascin
{"title":"Study Molecular Docking of pigment compounds derived from monascus sp as hepatitis B inhibitors","authors":"Anna Yuliana, Dikri Fadhlurrohman","doi":"10.30989/mik.v11i3.882","DOIUrl":"https://doi.org/10.30989/mik.v11i3.882","url":null,"abstract":"Background: Pigment is a dye derived from the mold of Monascus sp which is known to have antiviral activity, hepatitis B is an inflammation of the liver organs caused by the hepatitis B virus. Objective: This study aims to find out whether the five pigments of Monascus sp derivative compounds have the potential to be inhibitors of hepatitis BMethods: The method used in this study is molecular docking, with hepatitis B virus protein samples with the PDB code 5GMZ to be used as docking targets. Results: The results of docking showed that monascin compounds had the best inhibitor activity with energy binding of -7.96 kcal / mol and an inhibition constant of 1.46 uM, the formation of hydrogen and hydropobic bonds.The results of the RMSD chart from MD showed that the Monascin compound was stable at the beginning of the simulation with an average RMSD of 2.1 Å, on the RMSF chart it showed the lowest fluctuation when the compound bound to the amino acid PHE103.Conclusion: Of the five test ligands used, the potential as an inhibitor of hepatitis B is the compound Monascin","PeriodicalId":340508,"journal":{"name":"MEDIA ILMU KESEHATAN","volume":"222 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135287210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Customer loyalty is absolutely necessary because without customer loyalty the hospital cannot develop, it can even experience a decline in business that threatens the existence of the hospital. But to achieve customer loyalty many influencing factors such as service quality, word of mouth and customer satisfaction.Objective: Therefore it is necessary to know which factors significantly affect customer loyalty, so that the hospital can develop effective and efficient program and strategies.Methods: This study is an explanatory research by examining relationship of the variables. Respondents in this study were 195 people that were customer of the Surgical Oncology Outpatient Clinic of X Surgical Specialty Hospital. Data processing using the SEM PLS Method with Smart PLS application.Results: The results show that service quality have a positive and significant direct effect to customer satisfaction and loyalty. Word of mouth also shows positive and significant direct effect to customer satisfaction and loyalty. But this study failed to prove a significant direct effect of customer satisfaction to customer loyalty.Conclusion: We can significantly increase customer satisfaction and customer loyalty by increasing service quality and improve word of mouth activity. However customer satisfaction is not a significant factor for customer loyalty
{"title":"The Hubungan word of mouth, kualitas pelayanan, kepuasan dan loyalitas pelanggan klinik rawat jalan bedah onkologi di Rumah Sakit Khusus Bedah X","authors":"Thomas Darwin, Ratni Prima Lita, Rima Semiarty","doi":"10.30989/mik.v11i3.808","DOIUrl":"https://doi.org/10.30989/mik.v11i3.808","url":null,"abstract":"Background: Customer loyalty is absolutely necessary because without customer loyalty the hospital cannot develop, it can even experience a decline in business that threatens the existence of the hospital. But to achieve customer loyalty many influencing factors such as service quality, word of mouth and customer satisfaction.Objective: Therefore it is necessary to know which factors significantly affect customer loyalty, so that the hospital can develop effective and efficient program and strategies.Methods: This study is an explanatory research by examining relationship of the variables. Respondents in this study were 195 people that were customer of the Surgical Oncology Outpatient Clinic of X Surgical Specialty Hospital. Data processing using the SEM PLS Method with Smart PLS application.Results: The results show that service quality have a positive and significant direct effect to customer satisfaction and loyalty. Word of mouth also shows positive and significant direct effect to customer satisfaction and loyalty. But this study failed to prove a significant direct effect of customer satisfaction to customer loyalty.Conclusion: We can significantly increase customer satisfaction and customer loyalty by increasing service quality and improve word of mouth activity. However customer satisfaction is not a significant factor for customer loyalty","PeriodicalId":340508,"journal":{"name":"MEDIA ILMU KESEHATAN","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135287494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Novie Mauliku, Dyan Nugraeheni, Teguh Akbar Budiana, Elis Rosita
Background: Tuberculosis (TBC) until now still a public health problem, Indonesia take second position with highest TBC MDRload in the world. Tle level of TBC MDR treatment success in Indonesia on 2013 reach 51% despite Tuberculosis handling effort with DOTS strategy has been applied since 1995. One of DOTS strategy component is direct supervision swallowing drug by supervisory role o swallowing drug to prevent drug resistance.Objective: research is to know the related of supervisory role and patient compliance swallowing drug with incidence of MDR tuberculosiMethods: Research desain using case control. The sample case is target total population 15 peoples and control sample is TBC patient with drug sensitive 30 peoples. Data analysis is univariat analysis, bivariate using Chi SquareResults: shows there is a relationship between supervisory role of swallowing drug with TBC MDR p value=0,034; OR = 9,3 (95% CI: 1,080-80,627) and patient compliance swallowing drug p value=0,015; OR = 6,4 (95% CI: 1,606-25,644) with TBC MDRConclusion: PMO monitoring and medication adherence are associated with the incidence of MDR. Recommend to public health service place for intensity increase of TBC MDR patient home visit about the importance supervisory role and patient compliance swallowing drug
{"title":"Hubungan Peran Pengawas Menelan Obat (PMO) dan Kepatuhan Pasien Menelan Obat dengan Kejadian TBC MDR","authors":"Novie Mauliku, Dyan Nugraeheni, Teguh Akbar Budiana, Elis Rosita","doi":"10.30989/mik.v11i2.758","DOIUrl":"https://doi.org/10.30989/mik.v11i2.758","url":null,"abstract":"Background: Tuberculosis (TBC) until now still a public health problem, Indonesia take second position with highest TBC MDRload in the world. Tle level of TBC MDR treatment success in Indonesia on 2013 reach 51% despite Tuberculosis handling effort with DOTS strategy has been applied since 1995. One of DOTS strategy component is direct supervision swallowing drug by supervisory role o swallowing drug to prevent drug resistance.Objective: research is to know the related of supervisory role and patient compliance swallowing drug with incidence of MDR tuberculosiMethods: Research desain using case control. The sample case is target total population 15 peoples and control sample is TBC patient with drug sensitive 30 peoples. Data analysis is univariat analysis, bivariate using Chi SquareResults: shows there is a relationship between supervisory role of swallowing drug with TBC MDR p value=0,034; OR = 9,3 (95% CI: 1,080-80,627) and patient compliance swallowing drug p value=0,015; OR = 6,4 (95% CI: 1,606-25,644) with TBC MDRConclusion: PMO monitoring and medication adherence are associated with the incidence of MDR. Recommend to public health service place for intensity increase of TBC MDR patient home visit about the importance supervisory role and patient compliance swallowing drug","PeriodicalId":340508,"journal":{"name":"MEDIA ILMU KESEHATAN","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135287216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：