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Skeletal Scintigraphy in Assesing the Response of Prostate Cancer Metastases to Androgen Deprivation Therapy 骨骼闪烁成像评估癌症前列腺转移对雄激素剥夺治疗的反应
Pub Date : 2021-09-15 DOI: 10.20862/0042-4676-2021-102-4-232-239
S. Mironov, E. I. Vasilenko, P. M. Cholak, V. Masenko, M. Shariya, D. Ustyuzhanin, V. Sergienko
Androgen deprivation therapy (ADT) with luteinizing hormone-releasing hormone agonists is the basis for drug treatment in patients with metastatic prostate cancer (PC). An accurate assessment of the response of the tumor and its metastases is of primary importance for making a clinical decision regarding the continuation of treatment, changing the line of drugs or the nature of therapy. The presented clinical case illustrates the possibilities of 99mTc-pyrophosphate skeletal scintigraphy for monitoring the response of PC bone metastases to ADT. The efficiency of hormone therapy with Triptorelin has been confirmed by positive changes in the visual and quantitative scintigraphic signs that manifest the metabolic activity of bone tissue in the area of a metastatic lesion. This was manifested by a marked decrease in the intensity of 99mTc-pyrophosphate accumulation in the foci of bone pathology, by a reduction in the number of visualized hot foci, and by a gradual normalization of the scintigraphic pattern. This variant of the metabolic response of bone metastases to ADT correlated with the positive changes in laboratory parameters, as well as with the signs of reversal of the tumor and its metastases, as evidenced by magnetic resonance imaging.
雄激素剥夺疗法(ADT)结合促黄体激素释放激素激动剂是转移性前列腺癌(PC)患者药物治疗的基础。准确评估肿瘤及其转移的反应对于做出关于继续治疗、改变药物路线或治疗性质的临床决策至关重要。该临床病例说明了99mtc -焦磷酸盐骨骼闪烁成像监测PC骨转移对ADT的反应的可能性。雷普妥林激素治疗的有效性已被视觉和定量星形图的积极变化所证实,这些变化表明转移灶区域骨组织的代谢活性。这表现为骨病理病灶中99mtc焦磷酸盐积累强度的显著降低,可见热灶数量的减少,以及闪烁模式的逐渐正常化。这种骨转移对ADT代谢反应的变异与实验室参数的阳性变化以及肿瘤及其转移逆转的迹象相关,磁共振成像证实了这一点。
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引用次数: 0
Radiation Methods in the Diagnosis and Determination of Surgical Treatment Tactics for Primary Multiple Lung Carcinoid 放射方法在原发性多发性类肺癌的诊断及手术治疗策略的确定
Pub Date : 2021-09-15 DOI: 10.20862/0042-4676-2021-102-4-227-231
N. Nudnov, V. D. Сhkhikvadze, D. S. Kontorovich
The early and complete diagnosis of lung carcinoid tumors is of great interest in clinical oncology, since this is the basis for the possibility of using options for organ-sparing surgical treatment. According to the 2015 WHO classification, carcinoids belong to the group of neuroendocrine tumors and are divided into two types: a typical carcinoid and an atypical one. Based on the data available in the literature, there are from 0.2 to 2 cases per 100,000 population. The paper considers the possibilities of radiation studies in the early diagnosis of this tumor, as well as those of determining the tactics, type, and scope of surgical treatment.
肺部类癌的早期和完整诊断在临床肿瘤学中非常重要,因为这是使用保留器官的手术治疗的可能性的基础。根据2015年世界卫生组织分类,类癌属于神经内分泌肿瘤,分为两类:典型类癌和非典型类癌。根据文献中的可用数据,每100000人中有0.2至2例病例。本文考虑了放射研究在该肿瘤早期诊断中的可能性,以及确定手术治疗策略、类型和范围的可能性。
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引用次数: 0
Comparsion of Liver and Spleen Elastometry Features 肝脾弹性测量特征比较
Pub Date : 2021-09-15 DOI: 10.20862/0042-4676-2021-102-4-247-254
S. Morozov, V. Izranov
The review presents data on the comparison of the features of liver and spleen stiffness measurements and those on the impact of various conditions on the measurement results (the type of a sensor used, food intake, number of measurements, patient position, breathing phase, etc.). Literature has been sought in the PubMed and eLibrary databases. In particular, the liver and spleen stiffness values vary differently at the height of inspiration and expiration. This is due to organ engorgement with a change in intrathoracic and intraabdominal pressures, as well as to a reduction in splenic arterial flow during exhalation. The review gives published data on liver and spleen stiffness values in healthy volunteers. The spleen is a stiffer organ than the liver. The different liver and spleen stiffness is explained by the features of blood supply (the spleen receives the most blood supply from the intensive-flow artery; the liver does from the portal vein). The reasons for increasing the stiffness of these organs in both health and disease are described. Estimation of liver stiffness can be used to diagnose cirrhosis and portal hypertension. That of spleen stiffness can help in the diagnosis of portal hypertension and in the indirect diagnosis of the presence of esophageal varices and the nature of a splenic lesion.
这篇综述介绍了肝和脾硬度测量特征的比较数据,以及各种条件对测量结果的影响(使用的传感器类型、食物摄入量、测量次数、患者位置、呼吸相位等)。文献可在PubMed和eLibrary数据库中查阅。特别是,肝和脾硬度值在吸气和呼气的高度变化不同。这是由于器官充血,胸内和腹部压力发生变化,以及呼气过程中脾动脉流量减少。这篇综述给出了健康志愿者肝脏和脾脏硬度值的已发表数据。脾脏是一个比肝脏更坚硬的器官。肝脏和脾脏硬度的不同可以通过血液供应的特征来解释(脾脏从密集流动动脉获得最多的血液供应;肝脏从门静脉获得)。描述了在健康和疾病中增加这些器官硬度的原因。肝硬度的评估可用于肝硬化和门静脉高压的诊断。脾脏僵硬有助于诊断门静脉高压,并间接诊断食管静脉曲张的存在和脾脏病变的性质。
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引用次数: 0
FLASH Radiotherapy: a Promising Direction in the Fight Against Cancer 闪光放疗:抗癌的一个有前途的方向
Pub Date : 2021-09-15 DOI: 10.20862/0042-4676-2021-102-4-240-246
Аrtem V. Каrtashev, Тatiana N. Bochkareva, Аnastasiya S. Anokhina
At the present stage of scientific and technological progress, high-dose radiotherapy has become a common way to combat severe cancers. However, this treatment option is limited by normal tissues radiosensitivity. The developed technology of ultrashort pulse delivery of a dose of ionizing radiation to the zone of interest (FLASH radiotherapy) can achieve a high local control over tumor growth while sparing healthy tissues. This review summarizes the experimental findings supporting the possibility of transitioning to clinical studies of FLASH radiotherapy.
在科技进步的现阶段,大剂量放疗已成为治疗严重癌症的常用方法。然而,这种治疗选择受到正常组织放射敏感性的限制。发展的超短脉冲向感兴趣区域提供一定剂量的电离辐射(FLASH放疗)技术可以在保留健康组织的同时实现对肿瘤生长的高度局部控制。这篇综述总结了支持FLASH放疗过渡到临床研究的可能性的实验结果。
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引用次数: 0
Topical Issues of Rational Use of Iodine-Containing Contrast Agents in X-Ray Diagnostics 含碘造影剂在x射线诊断中的合理应用
Pub Date : 2021-09-15 DOI: 10.20862/0042-4676-2021-102-4-255-262
N. Shimanovskiy
The possibilities of rational use of iodine radiopaque agents in computed tomography and percutaneous coronary interventions are considered, taking into account the route, method of their administration and the viscosity of their solutions. When fixing the rate of iodine administration and the temperature of the injected solution, the required injection pressure of the contrast media is determined by the solution viscosity.
在计算机断层扫描和经皮冠状动脉介入治疗中合理使用碘透射线剂的可能性,考虑到它们的给药途径、方法和溶液的粘度。当确定碘的给药速率和注射溶液的温度时,造影剂所需的注射压力由溶液粘度决定。
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引用次数: 0
CT Diagnosis of Complications Arising from the Natural History and Treatment of COVID-19 新冠肺炎自然病史并发症的CT诊断及治疗
Pub Date : 2021-07-23 DOI: 10.20862/0042-4676-2021-102-3-183-195
S. V. Yadrentseva, N. Nudnov, E. G. Gasymov, E. V. Pron’kina
Computed tomography for coronavirus infection (COVID-19) is effective not only in making a diagnosis, but also in timely and accurately detecting some complications of this disease in different organs and systems. The paper shows various complications of coronavirus infection that a radiologist may face in practice, which develop both in the natural course and due to therapy for COVID-19, including hemorrhagic and thrombotic events in coagulopathy, pneumothorax, and pneumomediastinum as a result of the direct cytotoxic effect of SARS-CoV-2 on pneumocytes, and barotrauma during mechanical ventilation, as well as pathological fractures due to osteoporosis, including steroid osteoporosis that has developed during therapy with glucocorticosteroids. It considers the main causes and pathogenesis of various complications of coronavirus infection.
冠状病毒感染(新冠肺炎)的计算机断层扫描不仅可以有效地进行诊断,而且可以及时准确地检测不同器官和系统中的一些并发症。该论文显示了放射科医生在实践中可能面临的冠状病毒感染的各种并发症,这些并发症既发生在自然过程中,也发生在新冠肺炎的治疗中,包括由于SARS-CoV-2对肺细胞的直接细胞毒性作用而导致的凝血障碍、肺气肿和纵隔气肿中的出血和血栓事件,以及机械通气过程中的气压损伤,以及由于骨质疏松症引起的病理性骨折,包括在糖皮质激素治疗期间发展起来的类固醇性骨质疏松症。它考虑了冠状病毒感染各种并发症的主要原因和发病机制。
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引用次数: 0
Evaluation of Breast Vascular Calcifications as a Predictor for Coronary Artery Calcification 评价乳腺血管钙化作为冠状动脉钙化的预测因子
Pub Date : 2021-07-23 DOI: 10.20862/0042-4676-2021-102-3-196-202
D. A. Bazhenova, O. Puchkova, E. Mershina, V. Sinitsyn
Background. Cardiovascular diseases are one of the main causes of death among women, and current prevention paradigms may not be sufficient in this group. In this context, it has been suggested that the detection of breast vascular calcifications can improve the screening and assessment of the risk of cardiovascular diseases in apparently healthy women.Objective: to study the role of breast vascular calcifications as a potential predictor for coronary artery calcification. Material and methods. Examinations were made in 123 patients who underwent digital mammography and cardiac computed tomography to estimate a coronary artery calcium score.Results. The use of the Wilcoxon-Mann-Whitney W-test for abnormal distribution showed a relationship between the presence of breast vascular calcifications and calcium score (p< 0.001), and that between aortic wall calcification and calcium score (p< 0.001).Conclusion. Breast vascular calcifications detected by mammography are an indicator of a higher frequency of coronary artery calcification and, apparently, a predictor for the increased risk of cardiovascular disease.
背景。心血管疾病是妇女死亡的主要原因之一,目前的预防模式对这一群体可能还不够。在这种情况下,有人认为,乳房血管钙化的检测可以提高对表面健康妇女心血管疾病风险的筛查和评估。目的:探讨乳腺血管钙化对冠状动脉钙化的潜在预测作用。材料和方法。我们对123名接受数字乳房x线摄影和心脏计算机断层扫描的患者进行了检查,以估计冠状动脉钙评分。使用Wilcoxon-Mann-Whitney w检验异常分布显示乳腺血管钙化与钙评分之间存在相关性(p< 0.001),主动脉壁钙化与钙评分之间存在相关性(p< 0.001)。乳房x光检查发现的乳腺血管钙化是冠状动脉钙化频率较高的一个指标,显然是心血管疾病风险增加的一个预测指标。
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引用次数: 0
Malignant Phyllodes Tumor by the Example of a Clinical Case 恶性叶状肿瘤一例临床分析
Pub Date : 2021-07-23 DOI: 10.20862/0042-4676-2021-102-3-178-182
G. P. Korzhenkova, A. A. Kasymova
Breast cancer is the most common cancer in women worldwide, but there are also rarer types of breast neoplasms in clinical practice. One of these neoplasms is a phyllodes tumor. Due to the rare occurrence of phyllodes tumors and few studies of this pathology, there is today no information about the precise etiology and pathogenesis of this tumor. For the same reasons, it is very difficult to correctly and timely diagnose breast cancer, which requires both a highly qualified radiologist who first detects this disease in a patient and a pathologist who establishes a final morphological diagnosis. Existing studies, such as mammography and ultrasound, do not have reliable criteria for the diagnosis of phyllodes tumors and are unable to differentiate different histological types of these neoplasms, which further complicates the diagnosis of this pathology. Also, standards for the treatment of patients with this diagnosis have not been fully approved. The paper describes a clinical case of successful surgical treatment for a malignant phyllodes tumor of the left breast in a 47-year-old patient.
乳腺癌是全世界女性中最常见的癌症,但在临床实践中也有罕见的乳腺肿瘤类型。其中一种肿瘤是叶状瘤。由于叶状瘤的罕见发生和对其病理的研究较少,目前还没有关于该肿瘤确切的病因和发病机制的信息。由于同样的原因,正确和及时地诊断乳腺癌是非常困难的,这既需要一个高素质的放射科医生首先在病人身上发现这种疾病,也需要一个病理学家建立最终的形态学诊断。现有的研究,如乳房x光检查和超声检查,对叶状瘤的诊断没有可靠的标准,也无法区分这些肿瘤的不同组织学类型,这进一步使该病理的诊断复杂化。此外,患有这种诊断的患者的治疗标准尚未得到完全批准。本文描述了一个临床病例成功的手术治疗恶性叶状瘤的左乳房在一个47岁的病人。
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引用次数: 1
Perfusion Сomputed Tomography in the Diagnosis of Chronic Pancreatitis Complicated by Obstructive Jaundice and in the Differential Diagnosis with Pancreatic Head Adenocarcinoma 灌注Сomputed断层扫描对慢性胰腺炎合并梗阻性黄疸的诊断及与胰头腺癌的鉴别诊断
Pub Date : 2021-06-09 DOI: 10.20862/0042-4676-2021-102-2-80-88
T. Trofimova, M. Belikova
Objective: to compare the diagnostic effectiveness of computed tomography performed according to the standard protocol and using a perfusion program in the detection of chronic pseudotumoral pancreatitis complicated by obstructive jaundice and in the differential diagnosis with  pancreatic head adenocarcinoma. Material and methods. The investigation enrolled 153 patients with obstructive jaundice treated at the Saint Petersburg Hospital for War Veterans from 2016 to 2020. The cause of jaundice was chronic pancreatitis in 52 (34%) cases and pancreatic head adenocarcinoma in 101 (66%).  Endoscopic ultrasonography-guided histological verification using biopsy and examining the drugs after organ-sparing and radical resection interventions was obtained in all 101 patients (100%) with pancreatic  adenocarcinoma, and in 32 (61.5%) with chronic pancreatitis. A control group consisted of 30 patients with no anamnestic, clinical, or laboratory evidence of pancreatic diseases. All patients underwent abdominal computed  tomography according to the standard protocol and using a perfusion program. Results. The diagnostic effectiveness of the standard computed tomography protocol in the differential diagnosis of chronic pancreatitis and pancreatic adenocarcinoma was: sensitivity 95.5%, specificity 97.3%, and diagnostic accuracy 96.4%; whereas perfusion computed tomography had sensitivity  98.7%, specificity 99.3%, and diagnostic accuracy 98.6%. Conclusion. Perfusion computed tomography is a highly informative method for the differential diagnosis of chronic pancreatitis and pancreatic head adenocarcinoma in patients with obstructive jaundice.
{"title":"Perfusion Сomputed Tomography in the Diagnosis of Chronic Pancreatitis Complicated by Obstructive Jaundice and in the Differential Diagnosis with Pancreatic Head Adenocarcinoma","authors":"T. Trofimova, M. Belikova","doi":"10.20862/0042-4676-2021-102-2-80-88","DOIUrl":"https://doi.org/10.20862/0042-4676-2021-102-2-80-88","url":null,"abstract":"Objective: to compare the diagnostic effectiveness of computed tomography performed according to the standard protocol and using a perfusion program in the detection of chronic pseudotumoral pancreatitis complicated by obstructive jaundice and in the differential diagnosis with  pancreatic head adenocarcinoma. Material and methods. The investigation enrolled 153 patients with obstructive jaundice treated at the Saint Petersburg Hospital for War Veterans from 2016 to 2020. The cause of jaundice was chronic pancreatitis in 52 (34%) cases and pancreatic head adenocarcinoma in 101 (66%).  Endoscopic ultrasonography-guided histological verification using biopsy and examining the drugs after organ-sparing and radical resection interventions was obtained in all 101 patients (100%) with pancreatic  adenocarcinoma, and in 32 (61.5%) with chronic pancreatitis. A control group consisted of 30 patients with no anamnestic, clinical, or laboratory evidence of pancreatic diseases. All patients underwent abdominal computed  tomography according to the standard protocol and using a perfusion program. Results. The diagnostic effectiveness of the standard computed tomography protocol in the differential diagnosis of chronic pancreatitis and pancreatic adenocarcinoma was: sensitivity 95.5%, specificity 97.3%, and diagnostic accuracy 96.4%; whereas perfusion computed tomography had sensitivity  98.7%, specificity 99.3%, and diagnostic accuracy 98.6%. Conclusion. Perfusion computed tomography is a highly informative method for the differential diagnosis of chronic pancreatitis and pancreatic head adenocarcinoma in patients with obstructive jaundice.","PeriodicalId":34090,"journal":{"name":"Vestnik rentgenologii i radiologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67729293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Возможности магнитно-резонансной томографии в оценке гидроцефалии 脑积水评估磁共振成像的能力
Pub Date : 2021-06-09 DOI: 10.20862/0042-4676-2021-102-2-124-133
Р. М. Афандиев, Л. М. Фадеева, К. Д. Соложенцева, И. Н. Пронин
Magnetic resonance imaging (MRI) is presently one of the main methods in the diagnosis of diseases associated with impaired fluid dynamics. Rapidly developing MRI technologies allow us to get more and more information about the functional organization of both individual components and the entire cerebrospinal fluid system (CSF) as a whole. One of the most common diseases accompanied by impaired CSF flow, where the superiority of MRI among other non-invasive methods is especially obvious, is hydrocephalus.  The review considers the current capabilities of MRI in assessing CSF flow in various forms of hydrocephalus.
磁共振成像(MRI)是目前诊断与流体动力学损伤相关疾病的主要方法之一。快速发展的MRI技术使我们能够获得越来越多的关于个体成分和整个脑脊液系统(CSF)整体功能组织的信息。脑积水是脑脊液血流受损最常见的疾病之一,MRI在其他非侵入性方法中的优势尤为明显。这篇综述考虑了目前MRI在评估各种形式脑积水的脑脊液流量方面的能力。
{"title":"Возможности магнитно-резонансной томографии в оценке гидроцефалии","authors":"Р. М. Афандиев, Л. М. Фадеева, К. Д. Соложенцева, И. Н. Пронин","doi":"10.20862/0042-4676-2021-102-2-124-133","DOIUrl":"https://doi.org/10.20862/0042-4676-2021-102-2-124-133","url":null,"abstract":"Magnetic resonance imaging (MRI) is presently one of the main methods in the diagnosis of diseases associated with impaired fluid dynamics. Rapidly developing MRI technologies allow us to get more and more information about the functional organization of both individual components and the entire cerebrospinal fluid system (CSF) as a whole. One of the most common diseases accompanied by impaired CSF flow, where the superiority of MRI among other non-invasive methods is especially obvious, is hydrocephalus.  The review considers the current capabilities of MRI in assessing CSF flow in various forms of hydrocephalus.","PeriodicalId":34090,"journal":{"name":"Vestnik rentgenologii i radiologii","volume":"102 1","pages":"124-133"},"PeriodicalIF":0.0,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67729248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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Vestnik rentgenologii i radiologii
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