首页 > 最新文献

Vestnik rentgenologii i radiologii最新文献

英文 中文
Radiation-Induced Erectile Dysfunction in Prostate Cancer Patients: Up-to-Date View on Pathogenesis 前列腺癌患者的放射性勃起功能障碍:最新的发病机制
Pub Date : 2021-03-10 DOI: 10.20862/0042-4676-2021-102-1-66-74
R. Novikov, S. Novikov, V. Protoshchak, I. B. Dzhalilov, S. Litinskiy
The true causes of sexual disorders after radiation treatment of prostate cancer, among which the central role is occupied by erectile dysfunction, are still not fully clarified. The number of patients who undergo various radiation-exposure options as a radical therapy is steadily increasing, which makes the issue very relevant. This literature review provides up-to-date data on the most studied probable mechanisms of the erectile function status decline after radiation therapy for prostate cancer.
前列腺癌放射治疗后性功能障碍的真正原因,其中的中心作用是勃起功能障碍,仍然没有完全阐明。接受各种辐射暴露选择作为根治性治疗的患者数量正在稳步增加,这使得这个问题非常重要。本文综述了前列腺癌放射治疗后勃起功能状态下降的最新研究数据。
{"title":"Radiation-Induced Erectile Dysfunction in Prostate Cancer Patients: Up-to-Date View on Pathogenesis","authors":"R. Novikov, S. Novikov, V. Protoshchak, I. B. Dzhalilov, S. Litinskiy","doi":"10.20862/0042-4676-2021-102-1-66-74","DOIUrl":"https://doi.org/10.20862/0042-4676-2021-102-1-66-74","url":null,"abstract":"The true causes of sexual disorders after radiation treatment of prostate cancer, among which the central role is occupied by erectile dysfunction, are still not fully clarified. The number of patients who undergo various radiation-exposure options as a radical therapy is steadily increasing, which makes the issue very relevant. This literature review provides up-to-date data on the most studied probable mechanisms of the erectile function status decline after radiation therapy for prostate cancer.","PeriodicalId":34090,"journal":{"name":"Vestnik rentgenologii i radiologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43440448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Contrast Enhanced Ultrasound in the Diagnosis and Evaluation of the Efficiency of Chemotherapy in Patients with Colorectal Liver Metastases 超声造影对结直肠肝转移患者化疗效果的诊断和评价
Pub Date : 2021-01-25 DOI: 10.20862/0042-4676-2020-101-6-324-332
E. V. Kovaleva, G. Т. Sinyukova, T. Danzanova, P. I. Lepedatu, E. A. Gudilina, G. Allakhverdieva
Objective: to determine the possibilities of contrast-enhanced ultrasound (CEUS) in identifying and evaluating the efficiency of chemotherapy in patients with colorectal liver metastases (CLM).Material and methods. The investigation enrolled 28 patients with CLM. The patients were divided into two groups: Group 1 – 15 pretreatment patients; Group 2 – 13 posttreatment patients with process stabilization. All the patients underwent standard B-mode ultrasound of the liver and that using the contrast agent SonoVue ® (Bracco, Italy), by recording and estimating the parameters of the intensity-time curve (CIV). Liver CEUS assesses the nature of contrasting metastases in three phases (arterial, venous, and delay ones).Results. The investigators identified three types of contrast agent accumulation in CLM in the arterial phase: along the periphery of the lesions (in 60% of the patients of Group 1, in 76.9% in Group 2), homogeneously over the entire volume (in 26.7% in Group 1 and in 0.08% in Group 2), in parallel with intact liver parenchyma (13.3% in Group 1 and 23.02% in Group 2). In the delay phase, more metastases were detected in 4 cases (14.3%). Estimation of CIV parameters showed a difference at the beginning of contrast enhancement stages between the patients in both groups. Group 1 exhibited the early contrasting of liver metastases (19.3 sec); Group 2 displayed the late washout of a contrast agent (65.9 sec).Conclusion. CEUS versus B-mode ultrasound improves the imaging of liver metastases. The change in the vascular architectonics and hemodynamics in CLM after chemotherapy is reflected in the alteration of the rate of contrast accumulation and washout from the metastases, which allows CEUS to be used in the evaluation of the efficiency of this treatment.
目的:探讨超声造影(CEUS)鉴别和评价结直肠肝转移(CLM)患者化疗效果的可能性。材料和方法。该研究纳入了28例CLM患者。患者分为两组:1 - 15组预处理患者;2 - 13组患者治疗后椎突稳定。所有患者均行肝脏标准b超检查,并使用造影剂SonoVue®(Bracco, Italy),记录并估计强度-时间曲线(CIV)参数。肝超声造影评估三个阶段(动脉、静脉和延迟)转移的性质。研究人员在动脉期发现了三种类型的造影剂在CLM中的积聚:沿着病变周围(组1为60%,组2为76.9%),均匀分布于整个体积(组1为26.7%,组2为0.08%),平行于完整的肝实质(组1为13.3%,组2为23.02%)。在延迟期,4例患者(14.3%)检测到更多转移。两组患者在造影增强阶段开始时的CIV参数估计存在差异。1组肝转移比较早(19.3秒);组2出现对比剂的较晚洗脱(65.9秒)。超声造影与b超相比可改善肝转移的影像学表现。化疗后CLM血管结构和血流动力学的改变反映在转移灶造影剂积累和冲洗率的改变上,这使得超声造影可以用于评估这种治疗的效率。
{"title":"Contrast Enhanced Ultrasound in the Diagnosis and Evaluation of the Efficiency of Chemotherapy in Patients with Colorectal Liver Metastases","authors":"E. V. Kovaleva, G. Т. Sinyukova, T. Danzanova, P. I. Lepedatu, E. A. Gudilina, G. Allakhverdieva","doi":"10.20862/0042-4676-2020-101-6-324-332","DOIUrl":"https://doi.org/10.20862/0042-4676-2020-101-6-324-332","url":null,"abstract":"Objective: to determine the possibilities of contrast-enhanced ultrasound (CEUS) in identifying and evaluating the efficiency of chemotherapy in patients with colorectal liver metastases (CLM).Material and methods. The investigation enrolled 28 patients with CLM. The patients were divided into two groups: Group 1 – 15 pretreatment patients; Group 2 – 13 posttreatment patients with process stabilization. All the patients underwent standard B-mode ultrasound of the liver and that using the contrast agent SonoVue ® (Bracco, Italy), by recording and estimating the parameters of the intensity-time curve (CIV). Liver CEUS assesses the nature of contrasting metastases in three phases (arterial, venous, and delay ones).Results. The investigators identified three types of contrast agent accumulation in CLM in the arterial phase: along the periphery of the lesions (in 60% of the patients of Group 1, in 76.9% in Group 2), homogeneously over the entire volume (in 26.7% in Group 1 and in 0.08% in Group 2), in parallel with intact liver parenchyma (13.3% in Group 1 and 23.02% in Group 2). In the delay phase, more metastases were detected in 4 cases (14.3%). Estimation of CIV parameters showed a difference at the beginning of contrast enhancement stages between the patients in both groups. Group 1 exhibited the early contrasting of liver metastases (19.3 sec); Group 2 displayed the late washout of a contrast agent (65.9 sec).Conclusion. CEUS versus B-mode ultrasound improves the imaging of liver metastases. The change in the vascular architectonics and hemodynamics in CLM after chemotherapy is reflected in the alteration of the rate of contrast accumulation and washout from the metastases, which allows CEUS to be used in the evaluation of the efficiency of this treatment.","PeriodicalId":34090,"journal":{"name":"Vestnik rentgenologii i radiologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67729471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Investigation of the Safety of Radiopaque Compounds Based on Notification Cards on Adverse Reactions Registered in the Republic of Crimea 基于克里米亚共和国不良反应通报卡的放射性不透明化合物安全性调查
Pub Date : 2021-01-25 DOI: 10.20862/0042-4676-2020-101-6-344-353
A. V. Matveev, A. E. Krasheninnikov, E. .. Egorova
Objective. At the present stage of medicine development, the use of X-ray contrast agents tends to grow constantly and more than 60 million doses of radiopaque compounds (ROCs) are annually used.The objective of the study was to investigate adverse reactions (ARs) arising from the use of ROCs in patients living in the Republic of Crimea.Material and methods. The objects of the study performed were 69 notification cards on ARs to ROCs, which were registered in the regional database (registry) of spontaneous messages called ARCADe (Adverse Reactions in Crimea, Autonomic Database) in 2009–2018.Results. A larger number of cases of ARs identified in the Republic of Crimea were due to the administration of water-soluble low-osmolar ROCs (iohexol, iopromide, iodixanol) to patients for kidney examination. The main clinical manifestations were immediate hypersensitivity reactions. The number of ARs posing a threat to a patient’s life exceeded 30% of all cases of ARs registered in the Republic of Crimea. Twelve patients (17.4%) required hospitalization or its prolongation to relieve an emerging AR; temporary disability due to ARs to ROCs were observed in 2 cases. The measures to reduce the severity of ARs included drug discontinuation and correction in 65 cases (94.2%). A drug suspected of causing ARs was not discontinued in 3 cases (4.3%); however, additional drugs were needed to correct the ARs.Conclusion. Investigating the safety of ROCs on the basis of analyzing the notification cards on ARs registered in the Republic of Crimea in 2009–2018 could confirm the severity and seriousness of these reactions established by other researchers, which requires an individual approach to choosing a ROC, its dose, as well as monitoring of a patient’s health status both during the administration of agents and soon after the end of diagnostic procedures using ROCs.
目标。在医学发展的现阶段,x射线造影剂的使用呈不断增长趋势,每年使用的不透射线化合物(ROCs)超过6000万剂。该研究的目的是调查居住在克里米亚共和国的患者使用roc引起的不良反应(ARs)。材料和方法。进行的研究对象是2009 - 2018年在克里米亚不良反应区域数据库(ARCADe, Autonomic database)中登记的69张ARs到roc的通知卡。在克里米亚共和国发现的大量急性呼吸道感染病例是由于给患者进行肾脏检查时使用水溶性低渗透性活性氧(碘己醇、碘丙胺、碘沙醇)所致。主要临床表现为立即超敏反应。对患者生命构成威胁的急性呼吸道感染病例数量超过了克里米亚共和国登记的所有急性呼吸道感染病例的30%。12例患者(17.4%)需要住院或延长住院时间以缓解新出现的AR;2例因急性肾损伤引起暂时性残疾。65例(94.2%)患者采取药物停药和矫正等措施降低急性呼吸道感染的严重程度。3例(4.3%)未停用一种疑似引起急性呼吸道感染的药物;然而,需要额外的药物来纠正不良反应。在分析克里米亚共和国2009-2018年登记的ARs通知卡的基础上调查ROC的安全性,可以确认其他研究人员确定的这些反应的严重性和严重性,这需要个体方法来选择ROC及其剂量,以及在药物使用期间和使用ROC诊断程序结束后不久监测患者的健康状况。
{"title":"Investigation of the Safety of Radiopaque Compounds Based on Notification Cards on Adverse Reactions Registered in the Republic of Crimea","authors":"A. V. Matveev, A. E. Krasheninnikov, E. .. Egorova","doi":"10.20862/0042-4676-2020-101-6-344-353","DOIUrl":"https://doi.org/10.20862/0042-4676-2020-101-6-344-353","url":null,"abstract":"Objective. At the present stage of medicine development, the use of X-ray contrast agents tends to grow constantly and more than 60 million doses of radiopaque compounds (ROCs) are annually used.The objective of the study was to investigate adverse reactions (ARs) arising from the use of ROCs in patients living in the Republic of Crimea.Material and methods. The objects of the study performed were 69 notification cards on ARs to ROCs, which were registered in the regional database (registry) of spontaneous messages called ARCADe (Adverse Reactions in Crimea, Autonomic Database) in 2009–2018.Results. A larger number of cases of ARs identified in the Republic of Crimea were due to the administration of water-soluble low-osmolar ROCs (iohexol, iopromide, iodixanol) to patients for kidney examination. The main clinical manifestations were immediate hypersensitivity reactions. The number of ARs posing a threat to a patient’s life exceeded 30% of all cases of ARs registered in the Republic of Crimea. Twelve patients (17.4%) required hospitalization or its prolongation to relieve an emerging AR; temporary disability due to ARs to ROCs were observed in 2 cases. The measures to reduce the severity of ARs included drug discontinuation and correction in 65 cases (94.2%). A drug suspected of causing ARs was not discontinued in 3 cases (4.3%); however, additional drugs were needed to correct the ARs.Conclusion. Investigating the safety of ROCs on the basis of analyzing the notification cards on ARs registered in the Republic of Crimea in 2009–2018 could confirm the severity and seriousness of these reactions established by other researchers, which requires an individual approach to choosing a ROC, its dose, as well as monitoring of a patient’s health status both during the administration of agents and soon after the end of diagnostic procedures using ROCs.","PeriodicalId":34090,"journal":{"name":"Vestnik rentgenologii i radiologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67729549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Comparative Analysis of Computed Tomography and Laparoscopy Data in Preoperative Staging of Gastric Cancer 癌症术前计算机断层扫描与腹腔镜分期的对比分析
Pub Date : 2021-01-25 DOI: 10.20862/0042-4676-2020-101-6-333-343
N. Silanteva, T. A. Аgababyan, A. A. Kholeva, V. Skoropad, Z. Shavladze, S. A. Ivanov, L. Zhavoronkov
Objective: to compare the data of computed tomography (CT) and diagnostic laparoscopy (DL) in the preoperative estimation of the extension of gastric cancer.Material and methods. Data on 51 patients with a histologically confirmed diagnosis of gastric cancer were analyzed. CT and DL were performed in all the patients at an interval of 1–2 days during their preoperative examinations to determine the stage of a tumor process. Of the 51 patients, 34 (66.7%) were found to have no distant abdominal metastases and underwent radical surgery. CT and DL revealed distant abdominal organ metastases in 17 (33.3%) of the 51 patients. To evaluate the diagnostic efficiency of CT and DL, the investigators calculated the main characteristics (sensitivity, specificity) and auxiliary criteria (accuracy, positive (PPV) and negative (NPV) predictive values.Results. The findings suggested that the diagnostic efficiency of CT in determining the T category was a sensitivity of 86% and a specificity of 92%; and that of DL was 83% and 87%, respectively. CT in diagnosing a regional lymph node metastasis had a higher sensitivity than DL (88% vs. 63%), but a lower specificity than DL (80% vs. 90%). CT diagnosis of peritoneal carcinomatosis exhibited a sensitivity of 46%, a specificity of 97.4%, an accuracy of 84.3%, PPV of 85.7%, and NPV of 84.1%. The symptoms of peritoneal carcinomatosis were ascites, soft tissue nodules along the peritoneum, diffuse induration and thickening of abdominal tissue planes, and increased mesenteric vascularity.Conclusion. The combined use of CT and DL is a current algorithm for examining patients with gastric cancer. It makes it possible to obtain complete information about the extension of the process, to increase the accuracy of preoperative diagnosis and to form a group of patients to undergo radical surgery.
目的:比较计算机断层扫描(CT)和诊断性腹腔镜检查(DL)在癌症术前诊断中的应用价值。材料和方法。对51例经组织学确诊为癌症的患者的数据进行分析。所有患者在术前检查期间每隔1-2天进行CT和DL检查,以确定肿瘤过程的分期。在51例患者中,34例(66.7%)发现没有远处腹部转移,并接受了根治性手术。CT和DL显示51例患者中有17例(33.3%)存在远处腹部器官转移。为了评估CT和DL的诊断效率,研究人员计算了主要特征(敏感性、特异性)和辅助标准(准确性、阳性(PPV)和阴性(NPV)预测值。后果研究结果表明,CT在确定T类中的诊断效率为86%的敏感性和92%的特异性;DL分别为83%和87%。CT诊断区域淋巴结转移的敏感性高于DL(88%对63%),但特异性低于DL(80%对90%)。腹膜癌的CT诊断灵敏度为46%,特异性为97.4%,准确率为84.3%,PPV为85.7%,NPV为84.1%。腹膜癌的症状是腹水、腹膜软组织结节、腹部组织平面弥漫性硬结和增厚以及肠系膜血管增加。结论CT和DL的联合使用是目前用于检查癌症患者的算法。它可以获得有关该过程扩展的完整信息,提高术前诊断的准确性,并形成一组接受根治性手术的患者。
{"title":"Comparative Analysis of Computed Tomography and Laparoscopy Data in Preoperative Staging of Gastric Cancer","authors":"N. Silanteva, T. A. Аgababyan, A. A. Kholeva, V. Skoropad, Z. Shavladze, S. A. Ivanov, L. Zhavoronkov","doi":"10.20862/0042-4676-2020-101-6-333-343","DOIUrl":"https://doi.org/10.20862/0042-4676-2020-101-6-333-343","url":null,"abstract":"Objective: to compare the data of computed tomography (CT) and diagnostic laparoscopy (DL) in the preoperative estimation of the extension of gastric cancer.Material and methods. Data on 51 patients with a histologically confirmed diagnosis of gastric cancer were analyzed. CT and DL were performed in all the patients at an interval of 1–2 days during their preoperative examinations to determine the stage of a tumor process. Of the 51 patients, 34 (66.7%) were found to have no distant abdominal metastases and underwent radical surgery. CT and DL revealed distant abdominal organ metastases in 17 (33.3%) of the 51 patients. To evaluate the diagnostic efficiency of CT and DL, the investigators calculated the main characteristics (sensitivity, specificity) and auxiliary criteria (accuracy, positive (PPV) and negative (NPV) predictive values.Results. The findings suggested that the diagnostic efficiency of CT in determining the T category was a sensitivity of 86% and a specificity of 92%; and that of DL was 83% and 87%, respectively. CT in diagnosing a regional lymph node metastasis had a higher sensitivity than DL (88% vs. 63%), but a lower specificity than DL (80% vs. 90%). CT diagnosis of peritoneal carcinomatosis exhibited a sensitivity of 46%, a specificity of 97.4%, an accuracy of 84.3%, PPV of 85.7%, and NPV of 84.1%. The symptoms of peritoneal carcinomatosis were ascites, soft tissue nodules along the peritoneum, diffuse induration and thickening of abdominal tissue planes, and increased mesenteric vascularity.Conclusion. The combined use of CT and DL is a current algorithm for examining patients with gastric cancer. It makes it possible to obtain complete information about the extension of the process, to increase the accuracy of preoperative diagnosis and to form a group of patients to undergo radical surgery.","PeriodicalId":34090,"journal":{"name":"Vestnik rentgenologii i radiologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42612622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Multimodal Diagnosis of Right Ventricular Hamartoma 右心室错构瘤的多模态诊断
Pub Date : 2021-01-25 DOI: 10.20862/0042-4676-2020-101-6-354-357
V. Bereznitskiy, S. Alexandrova
Primary cardiac tumors occur quite rarely, while the symptoms in patients with this pathology are very nonspecific. The data of physical examination and the results of electrocardiography and radiography are often less informative. In this connection, modern high-tech medical imaging tools play a very important role in the identification and differential diagnosis of this category of space-occupying lesions. The paper describes a case of right ventricular hamartoma diagnosedd in an adult patient with the long-term asymptomatic course of the disease.
原发性心脏肿瘤很少发生,而这种病理患者的症状是非特异性的。体格检查、心电图和x线检查的结果往往信息较少。在这方面,现代高科技医学成像工具在这类占位性病变的识别和鉴别诊断中起着非常重要的作用。本文描述了一例右心室错构瘤的诊断在一个成人患者与疾病的长期无症状过程。
{"title":"Multimodal Diagnosis of Right Ventricular Hamartoma","authors":"V. Bereznitskiy, S. Alexandrova","doi":"10.20862/0042-4676-2020-101-6-354-357","DOIUrl":"https://doi.org/10.20862/0042-4676-2020-101-6-354-357","url":null,"abstract":"Primary cardiac tumors occur quite rarely, while the symptoms in patients with this pathology are very nonspecific. The data of physical examination and the results of electrocardiography and radiography are often less informative. In this connection, modern high-tech medical imaging tools play a very important role in the identification and differential diagnosis of this category of space-occupying lesions. The paper describes a case of right ventricular hamartoma diagnosedd in an adult patient with the long-term asymptomatic course of the disease.","PeriodicalId":34090,"journal":{"name":"Vestnik rentgenologii i radiologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67729563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective Assessment of mrTRG System Used for Determining the Efficiency of Neoadjuvant Chemoradiotherapy in Patients with Rectal Cancer mrTRG系统用于确定直肠癌患者新辅助放化疗疗效的前瞻性评估
Pub Date : 2021-01-01 DOI: 10.20862/0042-4676-2021-102-1-6-17
T. P. Berezovskaia, Ya. A. Dayneko, A. Nevolskikh, S. A. Ivanov, A. Kaprin
Background. Evaluation of the therapeutic effect of neoadjuvant chemoradiotherapy (nCRT) for rectal cancer (RC) is of prognostic value and allows to individually plan the type and extent of further surgical intervention. One of the most promising methods of MRI evaluation is magnetic resonance tumour regression grade (mrTRG) system. However, the reliability and safety of this method must be confirmed by the results of clinical trials and practical application.Objective: to analyze our experience in the prospective use of mrTRG system and evaluate the additional contribution of diffusion-weighted images (DWI) to its diagnostic efficiency.Material and methods. The mrTRG values were determined in 125 (including 30 with DWI) patients with locally advanced RC who received combined treatment with nCRT in Tsyb Medical Radiological Research Centre from 2015 to 2019. The obtained data were compared with the modified pathologic response based on Lushnikov’s definition, and the diagnostic parameters of differentiation of patients responding and nonresponding to nCRT were calculated.Results. When the mrTRG system was used without DWI, the following sensitivity and specificity values as well as positive and negative predictive values were obtained: 75%, 60%, 70% and 67%, respectively, with DWI – 87%, 87%, 87% and 87%, respectively.Conclusion. A prospective evaluation of the result of nCRT using the mrTRG system has moderate accuracy for stratification of patients responding and non-responding to nCRT, which requires the use of additional criteria for MRI scores to select patients who may receive less aggressive surgical treatment. Despite the small number of patients with DWI, we obtained higher values of the diagnostic parameters. In this regard, we consider it appropriate to use DWI when assessing the treatment response.
背景。评估直肠癌(RC)的新辅助放化疗(nCRT)的治疗效果具有预后价值,并允许单独计划进一步手术干预的类型和范围。磁共振肿瘤消退分级(mrTRG)系统是最有前途的MRI评估方法之一。但是,该方法的可靠性和安全性还需要临床试验和实际应用的结果来证实。目的:分析mrTRG系统未来应用的经验,并评价弥散加权图像(DWI)对其诊断效率的额外贡献。材料和方法。对2015 - 2019年在Tsyb医学放射研究中心接受nCRT联合治疗的局部晚期RC患者125例(其中DWI患者30例)进行mrTRG测定。将所得数据与基于Lushnikov定义的修正病理反应进行比较,并计算nCRT有反应与无反应患者的鉴别诊断参数。在不使用DWI的情况下,mrTRG系统的敏感性、特异性值以及阳性预测值和阴性预测值分别为75%、60%、70%和67%,DWI - 87%、87%、87%和87%。使用mrTRG系统对nCRT结果进行前瞻性评估,对于对nCRT有反应和无反应的患者进行分层具有中等准确性,这需要使用额外的MRI评分标准来选择可能接受较少积极手术治疗的患者。尽管DWI患者数量较少,但我们获得了较高的诊断参数值。在这方面,我们认为在评估治疗反应时使用DWI是合适的。
{"title":"Prospective Assessment of mrTRG System Used for Determining the Efficiency of Neoadjuvant Chemoradiotherapy in Patients with Rectal Cancer","authors":"T. P. Berezovskaia, Ya. A. Dayneko, A. Nevolskikh, S. A. Ivanov, A. Kaprin","doi":"10.20862/0042-4676-2021-102-1-6-17","DOIUrl":"https://doi.org/10.20862/0042-4676-2021-102-1-6-17","url":null,"abstract":"Background. Evaluation of the therapeutic effect of neoadjuvant chemoradiotherapy (nCRT) for rectal cancer (RC) is of prognostic value and allows to individually plan the type and extent of further surgical intervention. One of the most promising methods of MRI evaluation is magnetic resonance tumour regression grade (mrTRG) system. However, the reliability and safety of this method must be confirmed by the results of clinical trials and practical application.Objective: to analyze our experience in the prospective use of mrTRG system and evaluate the additional contribution of diffusion-weighted images (DWI) to its diagnostic efficiency.Material and methods. The mrTRG values were determined in 125 (including 30 with DWI) patients with locally advanced RC who received combined treatment with nCRT in Tsyb Medical Radiological Research Centre from 2015 to 2019. The obtained data were compared with the modified pathologic response based on Lushnikov’s definition, and the diagnostic parameters of differentiation of patients responding and nonresponding to nCRT were calculated.Results. When the mrTRG system was used without DWI, the following sensitivity and specificity values as well as positive and negative predictive values were obtained: 75%, 60%, 70% and 67%, respectively, with DWI – 87%, 87%, 87% and 87%, respectively.Conclusion. A prospective evaluation of the result of nCRT using the mrTRG system has moderate accuracy for stratification of patients responding and non-responding to nCRT, which requires the use of additional criteria for MRI scores to select patients who may receive less aggressive surgical treatment. Despite the small number of patients with DWI, we obtained higher values of the diagnostic parameters. In this regard, we consider it appropriate to use DWI when assessing the treatment response.","PeriodicalId":34090,"journal":{"name":"Vestnik rentgenologii i radiologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67729236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Mucinous Adenocarcinoma 肺粘液腺癌
Pub Date : 2021-01-01 DOI: 10.20862/0042-4676-2021-102-1-42-46
A. Usacheva, N. Silanteva, A. Petrosian, V. Usachev, A. Sidorin, S. A. Ivanov
Mucinous adenocarcinoma is a rare malignant tumor of the lung, which is accompanied by extremely scarce and nonspecific symptoms. This leads to an increase in the timing of its recognition, especially in young women. Given the poor prognosis of the pathlogy, the problem of its early diagnosis with histological and immuno-histochemical studies is extremely urgent. The presented clinical case demonstrates the possibilities of computed tomography with intravenous contrast enhancement in a young woman for the diagnosis of mucinous lung adenocarcinoma.
黏液性腺癌是一种罕见的肺恶性肿瘤,其症状非常罕见且非特异性。这导致人们认识到这一点的时间增加,尤其是在年轻女性中。由于该病预后不佳,对其进行早期诊断的组织学和免疫组织化学研究迫在眉睫。本文的临床病例证明了一名年轻女性的计算机断层扫描和静脉增强造影剂诊断肺粘液腺癌的可能性。
{"title":"Pulmonary Mucinous Adenocarcinoma","authors":"A. Usacheva, N. Silanteva, A. Petrosian, V. Usachev, A. Sidorin, S. A. Ivanov","doi":"10.20862/0042-4676-2021-102-1-42-46","DOIUrl":"https://doi.org/10.20862/0042-4676-2021-102-1-42-46","url":null,"abstract":"Mucinous adenocarcinoma is a rare malignant tumor of the lung, which is accompanied by extremely scarce and nonspecific symptoms. This leads to an increase in the timing of its recognition, especially in young women. Given the poor prognosis of the pathlogy, the problem of its early diagnosis with histological and immuno-histochemical studies is extremely urgent. The presented clinical case demonstrates the possibilities of computed tomography with intravenous contrast enhancement in a young woman for the diagnosis of mucinous lung adenocarcinoma.","PeriodicalId":34090,"journal":{"name":"Vestnik rentgenologii i radiologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67729650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tactics of Primary Emergency Radiation Diagnosis of Politrauma 原发性前列腺癌急诊放射诊断策略
Pub Date : 2021-01-01 DOI: 10.20862/0042-4676-2021-102-1-57-65
Y. Shapkin, P. Seliverstov, N. Y. Stekolnikov
The review considers the problem of choosing the optimal tactical approach to primary emergency radiation diagnosis of injuries during polytrauma based on data on indications for use, advantages and disadvantages of modern methods and protocols of radiation imaging. Literary sources were searched in the MedLine/ PubMed and eLibrary databases published from 2009 to 2019.The tactics of selective radiation diagnosis of polytrauma involves performing sequential studies (sonography, X-ray, computed tomography) of body areas in which damage is suspected by the mechanism of injury and clinical data, which limits the accuracy of the diagnosis and increases the duration of the examination. Primary multi-helical “whole-body”computed tomography including head, neck, chest, abdomen and pelvis examination, reduces the percentage of missed injuries, the duration of the examination and the time before emergency surgery, which can significantly reduce mortality in polytrauma. Its use is justified in patients with severe combined trauma if a high level of emergency hospital care organization is provided. Using “whole-body” computed tomography significantly increases the dose and economic costs, but the benefits of it for the survival of patients with polytrauma can outweigh the radiation risk and economic losses. Further development of technologies and protocols for multispiral computed tomography can significantly reduce the dose of radiation and the duration of the study. Clear and well-founded criteria for the selection of patients are needed for whom the use of “whole-body” computed tomography will be an effective strategy for radiation diagnosis.
本文根据现代放射成像方法和方案的适应症、优缺点等数据,考虑了选择最佳战术方法对多发创伤损伤进行初级急诊放射诊断的问题。在2009年至2019年出版的MedLine/ PubMed和library数据库中检索文献来源。多发创伤的选择性放射诊断策略包括对损伤机制和临床数据怀疑有损伤的身体部位进行顺序研究(超声、x线、计算机断层扫描),这限制了诊断的准确性,增加了检查的时间。初级多螺旋“全身”计算机断层扫描包括头、颈、胸、腹和骨盆检查,减少了漏伤的百分比、检查时间和急诊手术前的时间,这可以显著降低多发创伤的死亡率。如果提供高水平的紧急医院护理组织,则对严重合并创伤患者使用其是合理的。使用“全身”计算机断层扫描大大增加了剂量和经济成本,但它对多发创伤患者生存的好处可能超过辐射风险和经济损失。多螺旋计算机断层扫描技术和方案的进一步发展可以显著减少辐射剂量和研究时间。对于那些使用“全身”计算机断层扫描作为一种有效的放射诊断策略的患者,需要明确和有充分根据的选择标准。
{"title":"Tactics of Primary Emergency Radiation Diagnosis of Politrauma","authors":"Y. Shapkin, P. Seliverstov, N. Y. Stekolnikov","doi":"10.20862/0042-4676-2021-102-1-57-65","DOIUrl":"https://doi.org/10.20862/0042-4676-2021-102-1-57-65","url":null,"abstract":"The review considers the problem of choosing the optimal tactical approach to primary emergency radiation diagnosis of injuries during polytrauma based on data on indications for use, advantages and disadvantages of modern methods and protocols of radiation imaging. Literary sources were searched in the MedLine/ PubMed and eLibrary databases published from 2009 to 2019.The tactics of selective radiation diagnosis of polytrauma involves performing sequential studies (sonography, X-ray, computed tomography) of body areas in which damage is suspected by the mechanism of injury and clinical data, which limits the accuracy of the diagnosis and increases the duration of the examination. Primary multi-helical “whole-body”computed tomography including head, neck, chest, abdomen and pelvis examination, reduces the percentage of missed injuries, the duration of the examination and the time before emergency surgery, which can significantly reduce mortality in polytrauma. Its use is justified in patients with severe combined trauma if a high level of emergency hospital care organization is provided. Using “whole-body” computed tomography significantly increases the dose and economic costs, but the benefits of it for the survival of patients with polytrauma can outweigh the radiation risk and economic losses. Further development of technologies and protocols for multispiral computed tomography can significantly reduce the dose of radiation and the duration of the study. Clear and well-founded criteria for the selection of patients are needed for whom the use of “whole-body” computed tomography will be an effective strategy for radiation diagnosis.","PeriodicalId":34090,"journal":{"name":"Vestnik rentgenologii i radiologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67729701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic Aspergillosis in the Guise of Peripheral Lung Neoplasia 以周围性肺肿瘤为幌子的慢性曲霉病
Pub Date : 2021-01-01 DOI: 10.20862/0042-4676-2021-102-1-47-56
N. G. Nikolaeva, T. Golimbievskaya, O. Shadrivova, E. Desyatik, I. Bekhtereva, S-A. S. Barmicheva, Y. Borzova, Y. Krivolapov, I. E. Itskovich, N. Klimko
Two cases of postoperative diagnosis of chronic pulmonary aspergillosis are presented, which were previously regarded as malignant neoplasms. A decisive role in the detection of chronic pulmonary aspergillosis is played by computed tomography, but the diagnosis should be confirmed by laboratory tests. The importance of early diagnosis of chronic pulmonary aspergillosis is associated with high risk of complications during surgery without the use of antifungal drugs.
慢性肺曲霉病术后诊断两例,以前被认为是恶性肿瘤。计算机断层扫描在慢性肺曲霉病的诊断中起决定性作用,但诊断应通过实验室检查证实。早期诊断慢性肺曲霉病的重要性与不使用抗真菌药物的手术期间并发症的高风险有关。
{"title":"Chronic Aspergillosis in the Guise of Peripheral Lung Neoplasia","authors":"N. G. Nikolaeva, T. Golimbievskaya, O. Shadrivova, E. Desyatik, I. Bekhtereva, S-A. S. Barmicheva, Y. Borzova, Y. Krivolapov, I. E. Itskovich, N. Klimko","doi":"10.20862/0042-4676-2021-102-1-47-56","DOIUrl":"https://doi.org/10.20862/0042-4676-2021-102-1-47-56","url":null,"abstract":"Two cases of postoperative diagnosis of chronic pulmonary aspergillosis are presented, which were previously regarded as malignant neoplasms. A decisive role in the detection of chronic pulmonary aspergillosis is played by computed tomography, but the diagnosis should be confirmed by laboratory tests. The importance of early diagnosis of chronic pulmonary aspergillosis is associated with high risk of complications during surgery without the use of antifungal drugs.","PeriodicalId":34090,"journal":{"name":"Vestnik rentgenologii i radiologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67729684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computed Tomography Angiography in the Evaluation of Carotid Paragangliomas 颈动脉副神经节瘤的计算机断层造影评价
Pub Date : 2020-11-17 DOI: 10.20862/0042-4676-2020-101-5-276-282
M. V. Vishnyakova Jr., R. N. Lar'kov, M. Vishnyakova
Objective : to investigate the informative value of computed tomography (CT) angiography for the evaluation of carotid paragangliomas. Material and methods . Twelve patients with carotid paragangliomas were examined in the Department of X-ray Computed Tomography and Magnetic Resonance Imaging, Vladimirskiy Moscow Regional Research and Clinical Institute, in 2014-2019. Before surgery, we performed ultrasound imaging and CT angiography (Philips iCT 256 slices): non-contrast study, subsequent contrast enhancement (arterial and venous phases) using the intravenous bolus injection of 60 ml of non-ionic iso- or low-osmolar contrast media. The Shamblin criteria were used to evaluate paragangliomas. The extent of changes and the spread of mass tissue were estimated along the carotid artery walls. Surgery was performed in 11 out of 12 patients. Results. Unilateral and bilateral masses were identified in 10 and 2 cases, respectively. Two neoplasms that were characterized by small sizes and minimal involvement of carotid artery walls in the process were assigned to type I in accordance with the Shamblin classification. Type II masses (n = 5) were represented by a partial encasement of the internal and external carotid arteries by paraganglioma. Type III tumors (n = 7) were characterized by large sizes and encasement of all walls of the common, internal and external carotid arteries over a considerable length. No calcifications or necrotic areas were found in the structure of the neoplasms. Multiple small tortuous arterial vessels around the tumor were determined in 12 out of 14 cases. These changes did not match the overall length of the tumor and the degree of carotid artery encasement by the latter. Histological examination confirmed the diagnosis of paragangliomas in all cases. A pathologically altered lymph node was found in 1 case during the subsequent 5-month follow-up. Conclusion. CT angiography can assume the diagnosis of carotid paraganglioma based on its characteristic features and determine the type of tumor according to the Shamblin classification, which allows to plan the optimal surgical intervention.
目的:探讨计算机断层扫描(CT)血管造影术在评价颈动脉副神经节瘤中的信息价值。材料和方法。2014-2019年,12名颈动脉副神经节瘤患者在弗拉迪米尔斯基莫斯科地区研究与临床研究所X射线计算机断层扫描和磁共振成像科接受了检查。手术前,我们进行了超声成像和CT血管造影术(Philips iCT 256切片):非对比研究,随后使用静脉推注60ml非离子等渗或低渗造影剂进行对比增强(动脉和静脉期)。Shamblin标准用于评估副神经节瘤。沿着颈动脉壁估计肿块组织的变化程度和扩散。12名患者中有11名接受了手术。后果单侧和双侧肿块分别为10例和2例。根据Shamblin分类法,将两种肿瘤分为I型,其特征是体积小,颈动脉壁在此过程中的受累程度很小。II型肿块(n=5)表现为副神经节瘤部分包裹颈内动脉和外颈动脉。III型肿瘤(n=7)的特征是颈总动脉、颈内动脉和外颈动脉的所有壁都有很大的体积和包裹物。肿瘤结构中未发现钙化或坏死区。在14例病例中,有12例确定了肿瘤周围的多条弯曲的小动脉血管。这些变化与肿瘤的总长度和颈动脉被后者包裹的程度不匹配。组织学检查证实所有病例均诊断为副神经节瘤。在随后的5个月随访中,发现1例淋巴结发生病理改变。结论CT血管造影术可以根据颈动脉副神经节瘤的特征进行诊断,并根据Shamblin分类确定肿瘤类型,从而计划最佳的手术干预。
{"title":"Computed Tomography Angiography in the Evaluation of Carotid Paragangliomas","authors":"M. V. Vishnyakova Jr., R. N. Lar'kov, M. Vishnyakova","doi":"10.20862/0042-4676-2020-101-5-276-282","DOIUrl":"https://doi.org/10.20862/0042-4676-2020-101-5-276-282","url":null,"abstract":"Objective : to investigate the informative value of computed tomography (CT) angiography for the evaluation of carotid paragangliomas. Material and methods . Twelve patients with carotid paragangliomas were examined in the Department of X-ray Computed Tomography and Magnetic Resonance Imaging, Vladimirskiy Moscow Regional Research and Clinical Institute, in 2014-2019. Before surgery, we performed ultrasound imaging and CT angiography (Philips iCT 256 slices): non-contrast study, subsequent contrast enhancement (arterial and venous phases) using the intravenous bolus injection of 60 ml of non-ionic iso- or low-osmolar contrast media. The Shamblin criteria were used to evaluate paragangliomas. The extent of changes and the spread of mass tissue were estimated along the carotid artery walls. Surgery was performed in 11 out of 12 patients. Results. Unilateral and bilateral masses were identified in 10 and 2 cases, respectively. Two neoplasms that were characterized by small sizes and minimal involvement of carotid artery walls in the process were assigned to type I in accordance with the Shamblin classification. Type II masses (n = 5) were represented by a partial encasement of the internal and external carotid arteries by paraganglioma. Type III tumors (n = 7) were characterized by large sizes and encasement of all walls of the common, internal and external carotid arteries over a considerable length. No calcifications or necrotic areas were found in the structure of the neoplasms. Multiple small tortuous arterial vessels around the tumor were determined in 12 out of 14 cases. These changes did not match the overall length of the tumor and the degree of carotid artery encasement by the latter. Histological examination confirmed the diagnosis of paragangliomas in all cases. A pathologically altered lymph node was found in 1 case during the subsequent 5-month follow-up. Conclusion. CT angiography can assume the diagnosis of carotid paraganglioma based on its characteristic features and determine the type of tumor according to the Shamblin classification, which allows to plan the optimal surgical intervention.","PeriodicalId":34090,"journal":{"name":"Vestnik rentgenologii i radiologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45318318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Vestnik rentgenologii i radiologii
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1